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IUBMB CommentsPhosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline . A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
Synonyms
mapk, p38, erk1/2, p38 mapk, mitogen-activated protein kinase, map kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, p38mapk, p38 map kinase,
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mitogen-activated protein kinase spk1
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cell division control protein 7
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CSAID binding protein
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Cytokine suppressive anti-inflammatory drug binding protein
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MAP kinase p38 beta
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MAP kinase p38 delta
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MAP kinase p38 gamma
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MAP kinase p38alpha
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mitogen-activated protein kinase
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Mitogen-activated protein kinase p38 beta
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Mitogen-activated protein kinase p38 delta
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Mitogen-activated protein kinase p38 gamma
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Mitogen-activated protein kinase p38a
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Mitogen-activated protein kinase p38alpha
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Mitogen-activated protein kinase p38b
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mitogen-activated protein kinase spm1
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mitogen-activated protein kinase sty1
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stress-activated protein kinase 2a
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ATP:protein phosphotransferase (MAPKK-activated)
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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additional information
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additional information
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additional information
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enzyme plays a pivotal role in a variety of signal transduction pathways
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additional information
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enzyme plays a pivotal role in a variety of signal transduction pathways
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additional information
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enzyme functions as a part of the fission yeast growth control pathway
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additional information
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the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
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additional information
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the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
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additional information
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stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
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additional information
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stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
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additional information
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conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
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additional information
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conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
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additional information
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acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
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additional information
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acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
?
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additional information
?
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additional information
?
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enzyme plays a pivotal role in a variety of signal transduction pathways
-
-
?
additional information
?
-
-
enzyme plays a pivotal role in a variety of signal transduction pathways
-
-
?
additional information
?
-
enzyme functions as a part of the fission yeast growth control pathway
-
-
?
additional information
?
-
the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
-
-
?
additional information
?
-
-
the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
-
-
?
additional information
?
-
stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
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-
?
additional information
?
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stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
-
-
?
additional information
?
-
conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
-
-
?
additional information
?
-
-
conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
-
-
?
additional information
?
-
acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
-
-
?
additional information
?
-
-
acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (P41892)
brenda
Gonzalez, F.A.; Raden, D.L.; Rigby, M.R.; Davis, R.J.
Heterogeneous expression of four MAP kinase isoforms in human tissues
FEBS Lett.
304
170-178
1992
Schizosaccharomyces pombe (P27638), Homo sapiens (P28482), Homo sapiens (P31152), Homo sapiens
brenda
Gotoh, Y.; Nishida, E.; Shimanuki, M.; Toda, T.; Imai, Y.; Yamamoto, M.
Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase
Mol. Cell. Biol.
13
6427-6434
1993
Schizosaccharomyces pombe (P27638), Schizosaccharomyces pombe
brenda
Toda, T.; Shimanuki, M.; Yanagida, M.
Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases
Genes Dev.
5
60-73
1991
Schizosaccharomyces pombe (P27638)
brenda
Shiozaki, K.; Russell, P.
Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
Genes Dev.
10
2276-2288
1996
Schizosaccharomyces pombe (Q09892), Schizosaccharomyces pombe
brenda
Millar, J.B.; Buck, V.; Wilkinson, M.G.
Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast
Genes Dev.
9
2117-2130
1995
Schizosaccharomyces pombe (Q09892), Schizosaccharomyces pombe
brenda
Zaitsevskaya-Carter, T.; Cooper, J.A.
Spm1, a stress-activated MAP kinase that regulates morphogenesis in S. pombe
EMBO J.
16
1318-1331
1997
Schizosaccharomyces pombe (Q92398), Schizosaccharomyces pombe
brenda
Toda, T.; Dhut, S.; Superti-Furga, G.; Gotoh, Y.; Nishida, E.; Sugiura, R.; Kuno, T.
The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway
Mol. Cell. Biol.
16
6752-6764
1996
Schizosaccharomyces pombe (Q92398), Schizosaccharomyces pombe
brenda