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Information on EC 2.7.11.24 - mitogen-activated protein kinase

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EC Tree
IUBMB Comments
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline . A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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This record set is specific for:
UNIPROT: Q16659
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
mapk, p38, erk1/2, p38 mapk, mitogen-activated protein kinase, map kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, p38mapk, p38 map kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
mitogen-activated protein kinase 6
-
signal-regulated kinase 3
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cp38a
-
-
-
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cp38b
-
-
-
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CSAID binding protein
-
-
-
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CSBP
-
-
-
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Cytokine suppressive anti-inflammatory drug binding protein
-
-
-
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ERK5
-
-
-
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MAP kinase MXI2
-
-
-
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MAP kinase p38 beta
-
-
-
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MAP kinase p38 delta
-
-
-
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MAP kinase p38 gamma
-
-
-
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MAP kinase p38a
-
-
-
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MAP kinase p38alpha
-
-
-
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MAP kinase p38b
-
-
-
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MAPK
-
-
-
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mitogen-activated protein kinase
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-
-
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Mitogen-activated protein kinase p38 beta
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-
-
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Mitogen-activated protein kinase p38 delta
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-
-
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Mitogen-activated protein kinase p38 gamma
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-
-
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Mitogen-activated protein kinase p38a
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-
-
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Mitogen-activated protein kinase p38alpha
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-
-
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Mitogen-activated protein kinase p38b
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-
-
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p38b
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-
-
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SAPK2A
-
-
-
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stress-activated protein kinase 2a
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKK-activated)
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY hide
142243-02-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MK06_HUMAN
721
0
82681
Swiss-Prot
other Location (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Meloche, S.; Beatty, B.G.; Pellerin, J.
Primary structure, expression and chromosomal locus of a human homolog of rat ERK3
Oncogene
13
1575-1579
1996
Homo sapiens (Q16659), Homo sapiens
Manually annotated by BRENDA team
Zhu, A.X.; Zhao, Y.; Moller, D.E.; Flier, J.S.
Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3
Mol. Cell. Biol.
14
8202-8211
1994
Homo sapiens (Q16659), Homo sapiens
Manually annotated by BRENDA team