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Information on EC 2.7.11.22 - cyclin-dependent kinase and Organism(s) Bos taurus and UniProt Accession P48734

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IUBMB Comments
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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This record set is specific for:
Bos taurus
UNIPROT: P48734
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
cyclin-dependent kinase, cdk, p34cdc2, cdkl5, cdc2 kinase, cyclin-dependent kinase 5, cyclin-dependent kinase 2, cdc28, cyclin-dependent kinase 4, cyclin-dependent kinase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cell division control protein 2 homolog
-
Cdk5
-
-
cell division protein kinase 5
-
Cyclin-dependent kinase pef1
-
-
-
-
cyclin-dependent protein kinase 5
-
-
PHO85 homolog
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
CAS REGISTRY NUMBER
COMMENTARY hide
150428-23-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + protein
ADP + phosphoprotein
show the reaction diagram
proline-directed kinase
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
-
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
blastocyst-stage embryos
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CDK1_BOVIN
297
0
34025
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33931
x * 33931, SDS-PAGE
25000
33000
x * 33000 + x * 25000
450000
-
complex of Cdk5, GSK3beta, and tau protein, gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 33931, SDS-PAGE
?
x * 33000 + x * 25000
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yang, L.; Farin, C.E.
Identification of cDNAs encoding bovine cyclin B and Cdk1/Cdc2
Gene
141
283-286
1994
Bos taurus (P48734)
Manually annotated by BRENDA team
Lew, J.; Winkfein, R.J.; Paudel, H.K.; Wang, J.H.
Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2
J. Biol. Chem.
267
25922-25926
1992
Bos taurus (Q02399), Bos taurus
Manually annotated by BRENDA team
Li, T.; Hawkes, C.; Qureshi, H.Y.; Kar, S.; Paudel, H.K.
Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta
Biochemistry
45
3134-3145
2006
Bos taurus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team