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ATP + acidic alpha-syntrophin protein
ADP + acidic alpha-syntrophin phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + ADP-ribosylation factor GTPase activating protein 3 protein
ADP + ADP-ribosylation factor GTPase activating protein 3 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + AE binding protein 2 protein
ADP + AE binding protein 2 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + APEX nuclease protein
ADP + APEX nuclease phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ARAF serine/threonine protein kinase protein
ADP + ARAF serine/threonine protein kinase phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ATRIP protein
ADP + ATRIP phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + cAMP responsive element binding protein 3-like 2 protein
ADP + cAMP responsive element binding protein 3-like 2 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + CCAAT/enhancer binding protein gamma protein
ADP + CCAAT/enhancer binding protein gamma phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + cdc2
ADP + phosphorylated cdc2
phosphorylation of Thr161
-
-
?
ATP + cdc2-like protein
ADP + phosphorylated cdc2-like protein from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
ATP + cdk2
ADP + phosphorylated cdk2
-
-
-
?
ATP + coiled-coil domain protein 52 protein
ADP + coiled-coil domain protein 52 phosphoprotein
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + CPEB-associated factor Maskin protein
ADP + CPEB-associated factor Maskin phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + diacylglycerol kinase epsilon protein
ADP + diacylglycerol kinase epsilon phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + diphthamide biosynthesis protein 2 isoform a protein
ADP + diphthamide biosynthesis protein 2 isoform a phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + distal-less homeobox 1 isoform 1 protein
ADP + distal-less homeobox 1 isoform 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Erp1/emi2 protein
ADP + Erp1/emi2 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + establishment of cohesion-1 homologue 2 protein
ADP + establishment of cohesion-1 homologue 2 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ETS variant gene-1 protein
ADP + ETS variant gene-1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Fizzy1 protein
ADP + Fizzy1 phosphoprotein
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + glycogenin protein
ADP + glycogenin phosphoprotein
-
substrate of cyclin B/CDK1, not of cyclinA/CDK2
-
-
?
ATP + granulin isoform 1 precursor protein
ADP + granulin isoform 1 precursor phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + heat shock transcription factor 1 protein
ADP + heat shock transcription factor 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Hermes protein
ADP + Hermes phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + histone deacetylase 6 protein
ADP + histone deacetylase 6 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + histone H1
ADP + dephosphorylated hiostone H1
-
-
-
?
ATP + histone stem-loop binding protein
ADP + histone stem-loop binding phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + Kunitz type serine protease inhibitor 2 protein
ADP + Kunitz type serine protease inhibitor 2 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + lamina-associated protein 2-beta isoform protein
ADP + lamina-associated protein 2-beta isoform phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + LOC222229 protein
ADP + LOC222229 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + low density lipoprotein receptor adaptor protein 1 protein
ADP + low density lipoprotein receptor adaptor protein 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + MAP/microtubule affinity regulating kinase 3 protein
ADP + MAP/microtubule affinity regulating kinase 3 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + maternal embryonic leucine zipper kinase protein
ADP + maternal embryonic leucine zipper kinase phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + MGC86234 protein
ADP + MGC86234 phosphoprotein
-
i.e. potassium channel tetramerisation domaincontaining 3, substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + minor histocompatibility antigen HA-1 protein
ADP + minor histocompatibility antigen HA-1 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + neuronal cytoskeletal protein NF-H
ADP + phosphorylated neuronal cytoskeletal protein NF-H
-
-
-
?
ATP + neuronal cytoskeletal protein tau
ADP + phosphorylated neuronal cytoskeletal protein tau
-
-
-
?
ATP + neuronal cytoskeletal proteins NF-M
ADP + phosphorylated neuronal cytoskeletal protein NF-M
-
-
-
?
ATP + palmitoylated membrane protein 1 protein
ADP + palmitoylated membrane protein 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + PASCIN protein
ADP + PASCIN phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + phosphatidylinositol-4-phosphate 5-kinase type IIba protein
ADP + phosphatidylinositol-4-phosphate 5-kinase type IIba phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + PIF1 protein
ADP + PIF1 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + POM21 protein
ADP + POM21 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + pre-B-cell leukemia transcription factor 1 protein
ADP + pre-B-cell leukemia transcription factor 1 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin B/CDK1
-
-
?
ATP + RNA polymerase 1 protein
ADP + RNA polymerase 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + SEC14-like 1 isoform a protein
ADP + SEC14-like 1 isoform a phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + semaphorin 6D protein
ADP + semaphorin 6D phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + similar to bicaudal C homologue 1 protein
ADP + similar to bicaudal C homologue 1 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + similar to peroxisomal biogenesis factor 5 protein
ADP + similar to peroxisomal biogenesis factor 5 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + similar to Trigger of mitotic entry 1 protein
ADP + similar to Trigger of mitotic entry 1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + similar to Zinc finger protein 516 protein
ADP + similar to Zinc finger protein 516 phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 protein
ADP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + SmcX-Jumonji/ARID domain-containing protein 1C protein
ADP + SmcX-Jumonji/ARID domain-containing protein 1C phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + striatin protein
ADP + striatin phosphoprotein
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + TATA box-binding protein-associated factor 2F protein
ADP + TATA box-binding protein-associated factor 2F phosphoprotein
-
substrate of cyclin B/CDK1, not of cyclinA/CDK2
-
-
?
ATP + telomeric repeat binding factor 2 protein
ADP + telomeric repeat binding factor 2 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Tipin protein
ADP + Tipin phosphoprotein
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + v-raf murine sarcoma viral oncogene homolog B1 protein
ADP + v-raf murine sarcoma viraloncogene homolog B1 phosphoprotein
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Xenopus laevis protein associated with PRK1 protein
ADP + Xenopus laevis protein associated with PRK1 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + zinc finger protein 46 protein
ADP + zinc finger protein 46 phosphoprotein
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
additional information
?
-
ATP + Cdc20
ADP + phosphorylated Cdc20
-
substrate of Cdk1, rather than of Cdk2
-
-
?
ATP + Cdc20
ADP + phosphorylated Cdc20
-
in vitro substrate of Cdk1 and Cdk2
-
-
?
additional information
?
-
enzyme is involved in negative regulation of meiotic maturation of Xenopus oocytes
-
-
?
additional information
?
-
enzyme is required both for entry into S phase and mitosis
-
-
?
additional information
?
-
-
Cdks are cell cycle regulating enzymes, Cdk1 phosphorylates the anaphase-promoting complex-cyclosome during mitosis, which is a prerequisite for its activity but reduces the anaphase-promoting complex-cyclosome interaction with Cdc20 involving Mad2, the spindle checkpoint requires cyclin-dependent kinase activity, inhibition of Cdk overrides checkpoint-dependent arrest in eggs increasing the interaction of the anaphase-promoting complex-cyclosome with Cdc20, regulation overview
-
-
?
additional information
?
-
-
identification 35 substrates from screening for cyclin B/CDK1, and investigation of the differential specificity of cyclin B/CDK1 versus cyclin A/CDK1 and cyclin A/CDK2. About half the substrates are equally well phosphorylated regardless of the cyclin or the CDK, computational analysis, overview
-
-
?
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Labbe, J.C.; Martinez, A.M.; Fesquet, D.; Capony, J.P.; Darbon, J.M.; Derancourt, J.; Devault, A.; Morin, N.; Cavadore, J.C.; Doree, M.
p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes
EMBO J.
13
5155-5164
1994
Xenopus laevis (P20911)
brenda
Shuttleworth, J.; Godfrey, R.; Colman, A.
p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes
EMBO J.
9
3233-3240
1990
Xenopus laevis (P20911)
brenda
Poon, R.Y.; Yamashita, K.; Adamczewski, J.P.; Hunt, T.; Shuttleworth, J.
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2
EMBO J.
12
3123-3132
1993
Xenopus laevis (P23437)
brenda
Paris, J.; Le Guellec, R.; Couturier, A.; Le Guellec, K.; Omilli, F.; Camonis, J.; MacNeill, S.; Philippe, M.
Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2
Proc. Natl. Acad. Sci. USA
88
1039-1043
1991
Xenopus laevis (P23437), Xenopus laevis
brenda
Stern, B.; Ried, G.; Clegg, N.J.; Grigliatti, T.A.; Lehner, C.F.
Genetic analysis of the Drosophila cdc2 homolog
Development
117
219-232
1993
Xenopus laevis (P23437)
brenda
Clegg, N.J.; Whitehead, I.P.; Williams, J.A.; Spiegelman, G.B.; Grigliatti, T.A.
A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster
Genome
36
676-685
1993
Xenopus laevis (P23437)
brenda
Jimenez, J.; Alphey, L.; Nurse, P.; Glover, D.M.
Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string
EMBO J.
9
3565-3571
1990
Xenopus laevis (P23437)
brenda
Lehner, C.F.; O'Farrell, P.H.
Drosophila cdc2 homologul: a functional homolog is coexpressed with a cognate variant
EMBO J.
9
3573-3581
1990
Xenopus laevis (P23437), Drosophila melanogaster (P23573)
brenda
Fesquet, D.; Labbe, J.C.; Derancourt, J.; Capony, J.P.; Galas, S.; Girard, F.; Lorca, T.; Shuttleworth, J.; Doree, M.; Cavadore, J.C.
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues
EMBO J.
12
3111-3121
1993
Xenopus laevis (P24033), Xenopus laevis (P35567)
brenda
Pickham, K.M.; Meyer, A.N.; Li, J.; Donoghue, D.J.
Requirement of mosXe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lacking regulatory phosphorylation sites
Mol. Cell. Biol.
12
3192-3203
1992
Xenopus laevis (P24033), Xenopus laevis (P35567)
brenda
Gervasi, C.; Szaro, B.G.
The Xenopus laevis homologue to the neuronal cyclin-dependent kinase (cdk5) is expressed in embryos by gastrulation
Brain Res. Mol. Brain Res.
33
192-200
1995
Xenopus laevis (P51166), Xenopus laevis
brenda
D'Angiolella, V.; Mari, C.; Nocera, D.; Rametti, L.; Grieco, D.
The spindle checkpoint requires cyclin-dependent kinase activity
Genes Dev.
17
2520-2525
2003
Homo sapiens, Xenopus laevis
brenda
Errico, A.; Deshmukh, K.; Tanaka, Y.; Pozniakovsky, A.; Hunt, T.
Identification of substrates for cyclin dependent kinases
Adv. Enzyme Regul.
50
375-399
2010
Xenopus laevis
brenda