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Information on EC 2.7.11.22 - cyclin-dependent kinase and Organism(s) Schizosaccharomyces pombe and UniProt Accession O13958
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2.7.11.22 cyclin-dependent kinaseIUBMB Comments
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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Word Map
- 2.7.11.22
- cyclins
- p27kip1
- retinoblastoma
-
mitosis
-
cell-cycle
-
checkpoint
- histone
- tumorigenesis
- tumour
- bcl-2
- p16ink4a
-
s-phase
-
hyperphosphorylation
- leukemia
- prostate
- chromatin
- epidermal
-
exit
-
antiproliferative
- mapks
- caspase-3
-
mitogen
- tau
- xenopus
- spindle
- c-myc
-
interphase
-
quiescent
- oocyte
- pcna
-
fission
- alzheimer
- proteasome
- microtubule
- analysis
- medicine
- cdc25c
- pharmacology
- letrozole
-
cycle-dependent
-
polo-like
- chk1
-
p53-independent
- drug development
-
cytokinesis
- centrosome
-
prophase
-
postmitotic
-
receptor-positive
-
cycle-related
-
anaphase
-
aurora
-
metaphase
-
her2-negative
The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
cyclin-dependent kinase, cdk, p34cdc2, cdkl5, cdc2 kinase, cyclin-dependent kinase 5, cyclin-dependent kinase 2, cdc28, cyclin-dependent kinase 4, cyclin-dependent kinase 1, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
cell division control protein 2
-
Cyclin-dependent kinase pef1
-
-
-
-
PHO85 homolog
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
CAS REGISTRY NUMBER
COMMENTARY
150428-23-2
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
enzyme is required for both the G1-S and G2-M transitions during mitotic growth, and also for the second meiotic nuclear division
-
-
?
additional information
?
-
-
enzyme is required for both the G1-S and G2-M transitions during mitotic growth, and also for the second meiotic nuclear division
-
-
?
additional information
?
-
the enzyme is required during both G1 and G2 phases of the cell division cycle
-
-
?
additional information
?
-
-
the enzyme is required during both G1 and G2 phases of the cell division cycle
-
-
?
additional information
?
-
csk1 may encode a protein kinase physically associated with mcs2 or alternatively may function as an upstream activator of the mcs2-associated kinase
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
enzyme is required for both the G1-S and G2-M transitions during mitotic growth, and also for the second meiotic nuclear division
-
-
?
additional information
?
-
-
enzyme is required for both the G1-S and G2-M transitions during mitotic growth, and also for the second meiotic nuclear division
-
-
?
additional information
?
-
the enzyme is required during both G1 and G2 phases of the cell division cycle
-
-
?
additional information
?
-
-
the enzyme is required during both G1 and G2 phases of the cell division cycle
-
-
?
additional information
?
-
csk1 may encode a protein kinase physically associated with mcs2 or alternatively may function as an upstream activator of the mcs2-associated kinase
-
-
?
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
the enzyme is phosphorylated on tyrosine as well as Ser and Thr residues in exponentially growing Schizosaccharomyces pombe. At mitosis, the level of pp34 phosphorylation on both Thr and Tyr residues decreases, site of Tyr phosphorylation in pp34 is Tyr15, tyrosine phosphorylation/dephosphorylation directly regulates pp34 function
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C67W
mutation renders the resulting mutant protein p80cdc25-independent, while neither Leu, Ile nor Val has this effect
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (O13958), Schizosaccharomyces pombe (O74456), Schizosaccharomyces pombe (P04551), Schizosaccharomyces pombe (P36615)
Tanaka, K.; Okayama, H.
A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast
Mol. Biol. Cell
11
2845-2862
2000
Schizosaccharomyces pombe (O74456), Schizosaccharomyces pombe
Watson, P.; Davey, J.
Characterization of the Prk1 protein kinase from Schizosaccharomyces pombe
Yeast
14
485-492
1998
Schizosaccharomyces pombe (O13958), Schizosaccharomyces pombe
MacCoss, M.J.; McDonald, W.H.; Saraf, A.; Sadygov, R.; Clark, J.M.; Tasto, J.J.; Gould, K.L.; Wolters, D.; Washburn, M.; Weiss, A.; Clark, J.I.; Yates, J.R.
Shotgun identification of protein modifications from protein complexes and lens tissue
Proc. Natl. Acad. Sci. USA
99
7900-7905
2002
Schizosaccharomyces pombe (P04551)
Machida, M.; Yamazaki, S.; Kunihiro, S.; Tanaka, T.; Kushida, N.; Jinnno, K.; Haikawa, Y.; Yamazaki, J.; Yamamoto, S.; Sekine, M.; Oguchi, A.; Nagai, Y.; Sakai, M.; Aoki, K.; Ogura, K.; Kudoh, Y.; Kikuchi, H.; Zhang, M.Q.; Yanagida, M.
A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment
Yeast
16
71-80
2000
Schizosaccharomyces pombe (P04551)
MacNeill, S.A.; Nurse, P.
Mutational analysis of the fission yeast p34cdc2 protein kinase gene
Mol. Gen. Genet.
236
415-426
1993
Schizosaccharomyces pombe (P04551), Schizosaccharomyces pombe
Gould, K.L.; Nurse, P.
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
Nature
342
39-45
1989
Schizosaccharomyces pombe (P04551)
Brizuela, L.; Draetta, G.; Beach, D.
p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase
EMBO J.
6
3507-3514
1987
Schizosaccharomyces pombe (P04551), Schizosaccharomyces pombe
Hindley, J.; Phear, G.A.
Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases
Gene
31
129-134
1984
Schizosaccharomyces pombe (P04551), Schizosaccharomyces pombe
EXTERNAL LINKS (specific for EC-Number 2.7.11.22)
Transporter Classification Database (TCDB): 1.I.1.1.3
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