Reference on EC 2.7.11.20 - elongation factor 2 kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ryazanov, A.G.; Ward, M.D.; Mendola, C.E.; Pavur, K.S.; Dorovkov, M.V.; Wiedmann, M.; Erdjument-Bromage, H.; Tempst, P.; Parmer, T.G.; Prostko, C.R.; Germino, F.J.; Hait, W.N.
Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase
Proc. Natl. Acad. Sci. USA
94
4884-4889
1997
Homo sapiens (O00418), Homo sapiens, Caenorhabditis elegans (O01991), Caenorhabditis elegans, Mus musculus (O08796), Mus musculus, Rattus norvegicus (P70531)
Redpath, N.T.; Price, N.T.; Proud, C.G.
Cloning and expression of cDNA encoding protein synthesis elongation factor-2 kinase
J. Biol. Chem.
271
17547-17554
1996
Rattus norvegicus (P70531)
Sans, M.D.; Xie, Q.; Williams, J.A.
Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini
Biochem. Biophys. Res. Commun.
319
144-151
2004
Rattus norvegicus
Arora, S.; Yang, J.M.; Kinzy, T.G.; Utsumi, R.; Okamoto, T.; Kitayama, T.; Ortiz, P.A.; Hait, W.N.
Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines
Cancer Res.
63
6894-6899
2003
Homo sapiens
Arora, S.; Yang, J.M.; Hait, W.N.
Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinase
Cancer Res.
65
3806-3810
2005
Homo sapiens, Rattus norvegicus
Ren, H.; Tai, S.K.; Khuri, F.; Chu, Z.; Mao, L.
Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells
Cancer Res.
65
5841-5847
2005
Homo sapiens
Gutzkow, K.B.; Lahne, H.U.; Naderi, S.; Torgersen, K.M.; Skalhegg, B.; Koketsu, M.; Uehara, Y.; Blomhoff, H.K.
Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation
Cell. Signal.
15
871-881
2003
Homo sapiens
Browne, G.J.; Finn, S.G.; Proud, C.G.
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
J. Biol. Chem.
279
12220-12231
2004
Homo sapiens, Rattus norvegicus
Sattlegger, E.; Hinnebusch, A.G.
Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation
J. Biol. Chem.
280
16514-16521
2005
Saccharomyces cerevisiae
Carroll, M.; Warren, O.; Fan, X.; Sossin, W.S.
5-HT stimulates eEF2 dephosphorylation in a rapamycin-sensitive manner in Aplysia neurites
J. Neurochem.
90
1464-1476
2004
Aplysia californica
Rose, A.J.; Broholm, C.; Kiillerich, K.; Finn, S.G.; Proud, C.G.; Rider, M.H.; Richter, E.A.; Kiens, B.
Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men
J. Physiol.
569
223-228
2005
Homo sapiens
Browne, G.J.; Proud, C.G.
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin
Mol. Cell. Biol.
24
2986-2997
2004
Homo sapiens
Hait, W.N.; Wu, H.; Jin, S.; Yang, J.M.
Elongation factor-2 kinase: its role in protein synthesis and autophagy
Autophagy
2
294-296
2006
Homo sapiens
Wu, H.; Yang, J.M.; Jin, S.; Zhang, H.; Hait, W.N.
Elongation factor-2 kinase regulates autophagy in human glioblastoma cells
Cancer Res.
66
3015-3023
2006
Homo sapiens
Guo, F.; Cavener, D.R.
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid
Cell Metab.
5
103-114
2007
Mus musculus, Mus musculus C57/BL6J
Hong-Brown, L.Q.; Brown, C.R.; Huber, D.S.; Lang, C.H.
Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes
J. Biol. Chem.
282
3702-3712
2007
Mus musculus
Connolly, E.; Braunstein, S.; Formenti, S.; Schneider, R.J.
Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells
Mol. Cell. Biol.
26
3955-3965
2006
Homo sapiens
Sataranatarajan, K.; Mariappan, M.M.; Lee, M.J.; Feliers, D.; Choudhury, G.G.; Barnes, J.L.; Kasinath, B.S.
Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by rapamycin
Am. J. Pathol.
171
1733-1742
2007
Mus musculus
Iizuka, A.; Sengoku, K.; Iketani, M.; Nakamura, F.; Sato, Y.; Matsushita, M.; Nairn, A.C.; Takamatsu, K.; Goshima, Y.; Takei, K.
Calcium-induced synergistic inhibition of a translational factor eEF2 in nerve growth cones
Biochem. Biophys. Res. Commun.
353
244-250
2007
Gallus gallus
Crawley, S.W.; Cote, G.P.
Determinants for substrate phosphorylation by Dictyostelium myosin II heavy chain kinases A and B and eukaryotic elongation factor-2 kinase
Biochim. Biophys. Acta
1784
908-915
2008
Mus musculus
Boyce, M.; Py, B.F.; Ryazanov, A.G.; Minden, J.S.; Long, K.; Ma, D.; Yuan, J.
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death
Cell Death Differ.
15
589-599
2008
Mus musculus (O08796)
Smith, E.M.; Proud, C.G.
Cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner
EMBO J.
27
1005-1016
2008
Homo sapiens (O00418)
Clark, K.; Middelbeek, J.; Dorovkov, M.V.; Figdor, C.G.; Ryazanov, A.G.; Lasonder, E.; van Leeuwen, F.N.
The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC
FEBS Lett.
582
2993-2997
2008
Mus musculus
Hong-Brown, L.Q.; Brown, C.R.; Huber, D.S.; Lang, C.H.
Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase
J. Cell. Biochem.
105
814-823
2008
Mus musculus
Ayada, K.; Yokota, K.; Kawahara, Y.; Yamamoto, Y.; Hirai, K.; Inaba, T.; Kita, M.; Okada, H.; Yamamoto, K.; Oguma, K.
Immune reactions against elongation factor 2 kinase: specific pathogenesis of gastric ulcer from Helicobacter pylori infection
Clin. Dev. Immunol.
2009
850623
2009
Homo sapiens (O00418), Homo sapiens
Rose, A.J.; Alsted, T.J.; Jensen, T.E.; Kobber?, J.B.; Maarbjerg, S.J.; Jensen, J.; Richter, E.A.
A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions
J. Physiol.
587
1547-1563
2009
Rattus norvegicus
Bunpo, P.; Cundiff, J.K.; Reinert, R.B.; Wek, R.C.; Aldrich, C.J.; Anthony, T.G.
The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase
J. Nutr.
140
2020-2027
2010
Mus musculus
Huber-Keener, K.J.; Evans, B.R.; Ren, X.; Cheng, Y.; Zhang, Y.; Hait, W.N.; Yang, J.M.
Phosphorylation of elongation factor-2 kinase differentially regulates the enzymes stability under stress conditions
Biochem. Biophys. Res. Commun.
424
308-314
2012
Homo sapiens
Pigott, C.R.; Mikolajek, H.; Moore, C.E.; Finn, S.J.; Phippen, C.W.; Werner, J.M.; Proud, C.G.
Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains
Biochem. J.
442
105-118
2012
Homo sapiens
Pyr Dit Ruys, S.; Wang, X.; Smith, E.M.; Herinckx, G.; Hussain, N.; Rider, M.H.; Vertommen, D.; Proud, C.G.
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase
Biochem. J.
442
681-692
2012
Homo sapiens
Devkota, A.K.; Tavares, C.D.; Warthaka, M.; Abramczyk, O.; Marshall, K.D.; Kaoud, T.S.; Gorgulu, K.; Ozpolat, B.; Dalby, K.N.
Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact
Biochemistry
51
2100-2112
2012
Homo sapiens
Tavares, C.D.; OBrien, J.P.; Abramczyk, O.; Devkota, A.K.; Shores, K.S.; Ferguson, S.B.; Kaoud, T.S.; Warthaka, M.; Marshall, K.D.; Keller, K.M.; Zhang, Y.; Brodbelt, J.S.; Ozpolat, B.; Dalby, K.N.
Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence
Biochemistry
51
2232-2245
2012
Homo sapiens (O00418), Homo sapiens
Cheng, Y.; Ren, X.; Zhang, Y.; Patel, R.; Sharma, A.; Wu, H.; Robertson, G.P.; Yan, L.; Rubin, E.; Yang, J.M.
eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206
Cancer Res.
71
2654-2663
2011
Homo sapiens
Weatherill, D.B.; McCamphill, P.K.; Pethoukov, E.; Dunn, T.W.; Fan, X.; Sossin, W.S.
Compartment-specific, differential regulation of eukaryotic elongation factor 2 and its kinase within Aplysia sensory neurons
J. Neurochem.
117
841-855
2011
Aplysia californica (F8S834)
Gentz, S.H.; Bertollo, C.M.; Souza-Fagundes, E.M.; da Silva, A.M.
Implication of eIF2alpha kinase GCN2 in induction of apoptosis and endoplasmic reticulum stress-responsive genes by sodium salicylate
J. Pharm. Pharmacol.
65
430-440
2013
Mus musculus
Arriazu, E.; Ruiz de Galarreta, M.; Lopez-Zabalza, M.J.; Leung, T.M.; Nieto, N.; Iraburu, M.J.
GCN2 kinase is a key regulator of fibrogenesis and acute and chronic liver injury induced by carbon tetrachloride in mice
Lab. Invest.
93
303-310
2013
Homo sapiens, Mus musculus
Byrne, E.H.; Prosser, I.; Muttucumaru, N.; Curtis, T.Y.; Wingler, A.; Powers, S.; Halford, N.G.
Overexpression of GCN2-type protein kinase in wheat has profound effects on free amino acid concentration and gene expression
Plant Biotechnol. J.
10
328-340
2012
Triticum aestivum
Abramczyk, O.; Tavares, C.D.; Devkota, A.K.; Ryazanov, A.G.; Turk, B.E.; Riggs, A.F.; Ozpolat, B.; Dalby, K.N.
Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli
Protein Expr. Purif.
79
237-244
2011
Homo sapiens (O00418), Homo sapiens
He, H.; Singh, I.; Wek, S.; Dey, S.; Baird, T.; Wek, R.; Georgiadis, M.
Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals
J. Biol. Chem.
289
15023-15034
2014
Saccharomyces cerevisiae (P15442), Mus musculus (Q9QZ05)
Kenney, J.W.; Moore, C.E.; Wang, X.; Proud, C.G.
Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles
Adv. Biol. Regul.
55
15-27
2014
Homo sapiens, Mus musculus (O08796)
Usui, T.; Okada, M.; Hara, Y.; Yamawaki, H.
Eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation
Am. J. Physiol. Heart Circ. Physiol.
305
H756-H768
2013
Homo sapiens (O00418), Rattus norvegicus (P70531), Rattus norvegicus Wistar (P70531)
Wang, X.; Xie, J.; da Mota, S.R.; Moore, C.E.; Proud, C.G.
Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity
Biochem. J.
467
321-331
2015
Homo sapiens (O00418)
Lazarus, M.; Levin, R.; Shokat, K.
Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response
Cell. Signal.
29
78-83
2017
Homo sapiens (O00418)
Liao, Y.; Chu, H.P.; Hu, Z.; Merkin, J.J.; Chen, J.; Liu, Z.; Degenhardt, K.; White, E.; Ryazanov, A.G.
Paradoxical roles of elongation factor-2 kinase in stem cell survival
J. Biol. Chem.
291
19545-19557
2016
Mus musculus (O08796)
Kenney, J.W.; Genheden, M.; Moon, K.M.; Wang, X.; Foster, L.J.; Proud, C.G.
Eukaryotic elongation factor 2 kinase regulates thesynthesis of microtubule-related proteins in neurons
J. Neurochem.
136
276-284
2016
Mus musculus (O08796), Mus musculus, Mus musculus C57/BL6J (O08796)
Moore, C.E.; Mikolajek, H.; Regufe da Mota, S.; Wang, X.; Kenney, J.W.; Werner, J.M.; Proud, C.G.
Elongation factor 2 kinase is regulated by proline hydroxylation and protects cells during hypoxia
Mol. Cell. Biol.
35
1788-1804
2015
Homo sapiens (O00418), Mus musculus (O08796)
Cheng, Y.; Ren, X.; Yuan, Y.; Shan, Y.; Li, L.; Chen, X.; Zhang, L.; Takahashi, Y.; Yang, J.W.; Han, B.; Liao, J.; Li, Y.; Harvey, H.; Ryazanov, A.; Robertson, G.P.; Wan, G.; Liu, D.; Chen, A.F.; Tao, Y.; Yang, J.M.
eEF-2 kinase is a critical regulator of Warburg effect through controlling PP2A-A synthesis
Oncogene
2016
1-16
2016
Homo sapiens (O00418)
Lee, K.; Alphonse, S.; Piserchio, A.; Tavares, C.D.; Giles, D.H.; Wellmann, R.M.; Dalby, K.N.; Ghose, R.
Structural basis for the recognition of eukaryotic elongation factor 2 kinase by calmodulin
Structure
24
1441-1451
2016
Homo sapiens (O00418)
Xiao, T.; Liu, R.; Proud, C.G.; Wang, M.W.
A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors
Acta Pharm. Sin. B
6
557-563
2016
Homo sapiens
Liu, R.; Proud, C.G.
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases
Acta Pharmacol. Sin.
37
285-294
2016
Homo sapiens (O00418), Homo sapiens
Yu, P.; Wang, H.Y.; Tian, M.; Li, A.X.; Chen, X.S.; Wang, X.L.; Zhang, Y.; Cheng, Y.
Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro
Acta Pharmacol. Sin.
40
1237-1244
2019
Homo sapiens (O00418), Homo sapiens
Kameshima, S.; Okada, M.; Yamawaki, H.
Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts
Apoptosis
24
359-368
2019
Rattus norvegicus (P70531)
Kameshima, S.; Okada, M.; Ikeda, S.; Watanabe, Y.; Yamawaki, H.
Coordination of changes in expression and phosphorylation of eukaryotic elongation factor 2 (eEF2) and eEF2 kinase in hypertrophied cardiomyocytes
Biochem. Biophys. Rep.
7
218-224
2016
Mus musculus (O08796), Rattus norvegicus (P70531)
Will, N.; Piserchio, A.; Snyder, I.; Ferguson, S.B.; Giles, D.H.; Dalby, K.N.; Ghose, R.
Structure of the C-terminal helical repeat domain of eukaryotic elongation factor 2 kinase
Biochemistry
55
5377-5386
2016
Homo sapiens (O00418)
Wang, X.; Xie, J.; Proud, C.G.
Eukaryotic elongation factor 2 kinase (eEF2K) in cancer
Cancers (Basel)
9
162
2017
Homo sapiens (O00418)
Moore, C.E.; Wang, X.; Xie, J.; Pickford, J.; Barron, J.; Regufe da Mota, S.; Versele, M.; Proud, C.G.
Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy
Cell. Signal.
28
284-293
2016
Homo sapiens (O00418)
Pan, Z.; Chen, Y.; Liu, J.; Jiang, Q.; Yang, S.; Guo, L.; He, G.
Design, synthesis, and biological evaluation of polo-like kinase 1/eukaryotic elongation factor 2 kinase (PLK1/EEF2K) dual inhibitors for regulating breast cancer cells apoptosis and autophagy
Eur. J. Med. Chem.
144
517-528
2018
Homo sapiens (O00418)
Wang, Y.; Huang, G.; Wang, Z.; Qin, H.; Mo, B.; Wang, C.
Elongation factor-2 kinase acts downstream of p38 MAPK to regulate proliferation, apoptosis and autophagy in human lung fibroblasts
Exp. Cell Res.
363
291-298
2018
Homo sapiens
Xie, J.; Shen, K.; Lenchine, R.V.; Gethings, L.A.; Trim, P.J.; Snel, M.F.; Zhou, Y.; Kenney, J.W.; Kamei, M.; Kochetkova, M.; Wang, X.; Proud, C.G.
Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis
Int. J. Cancer
142
1865-1877
2018
Homo sapiens (O00418)
Zhou, Y.; Li, Y.; Xu, S.; Lu, J.; Zhu, Z.; Chen, S.; Tan, Y.; He, P.; Xu, J.; Proud, C.G.; Xie, J.; Shen, K.
Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3
Int. J. Cancer
146
1383-1395
2020
Homo sapiens
Tavares, C.D.; Giles, D.H.; Stancu, G.; Chitjian, C.A.; Ferguson, S.B.; Wellmann, R.M.; Kaoud, T.S.; Ghose, R.; Dalby, K.N.
Signal integration at elongation factor 2 kinase the roles of calcium, calmodulin, and Ser-500 phosphorylation
J. Biol. Chem.
292
2032-2045
2017
Homo sapiens (O00418)
Piserchio, A.; Will, N.; Giles, D.H.; Hajredini, F.; Dalby, K.N.; Ghose, R.
Solution structure of the carboxy-terminal tandem repeat domain of eukaryotic elongation factor 2 kinase and its role in substrate recognition
J. Mol. Biol.
431
2700-2717
2019
Homo sapiens (O00418)
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