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Information on EC 2.7.11.18 - myosin-light-chain kinase and Organism(s) Rattus norvegicus and UniProt Accession P20689
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2.7.11.18 myosin-light-chain kinaseIUBMB Comments
Requires Ca2+ and calmodulin for activity. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly.
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Word Map
- 2.7.11.18
-
contractile
- actin
- junction
- artery
- rho
- pkc
- agonist
- gizzard
- cytoskeletal
- actomyosin
-
tension
- occludin
-
rock
-
calmodulin-binding
-
actin-activated
-
isometric
-
rho-associated
- mlc20
-
paracellular
-
ca2+-independent
-
actin-myosin
-
rho-kinase
- wortmannin
-
zonula
- mypt1
-
cam-binding
-
actin-binding
-
cam-dependent
- trifluoperazine
- caldesmon
-
myofilament
-
hyperpermeability
-
thrombin-induced
-
thiophosphorylation
- mg2+-atpase
- calyculin
-
pseudosubstrate
- blebbistatin
- idella
-
diphosphorylation
- calponin
-
cross-bridge
- meromyosin
- medicine
-
mgatpase
-
myosin-binding
-
monoxime
-
n-6-aminohexyl-5-chloro-1-naphthalenesulfonamide
-
calmodulin-activated
-
superprecipitation
- cak
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
mlck, myosin light chain kinase, myosin light-chain kinase, mlc kinase, smooth muscle myosin light chain kinase, smmlck, nmmlck, myosin kinase, cmlck, skmlck, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
calcium/calmodulin-dependent myosin light chain kinase
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-
-
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kinase, myosin light-chain (phosphorylating)
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-
-
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MLCK
myosin kinase
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-
-
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myosin light chain kinase
myosin light chain protein kinase
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-
-
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myosin light-chain kinase
-
-
-
-
smooth-muscle-myosin-light-chain kinase
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-
-
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MLCK
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-
myosin light chain kinase
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[myosin light chain] O-phosphotransferase
Requires Ca2+ and calmodulin for activity. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY
51845-53-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + myosin regulatory light chain
ADP + myosin regulatory light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of non-muscle myosin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-residues in smooth and skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is synapsin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
kinase from skeletal muscle with broader specificity than smooth muscle kinase
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-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in myosin phosphorylation and enzyme secretion
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
in airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain is an important step in calcium signalling pathway from the variation of Ca2+ concentration in cytosol to the force development
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
myosin light chain is phosphorylated at Thr 18 and Ser 19 by myosin light chain kinase
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
myyosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
smooth muscle myosin
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
myosin II
-
-
?
additional information
?
-
MLCK is a substrate of AMP-activated protein kinase, AMPK
-
-
?
additional information
?
-
-
skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate
-
-
?
additional information
?
-
-
inhibition of the enzyme retards the growth of prostate cancer cells
-
-
?
additional information
?
-
-
MLCK is probably involved in development of diabetic nephropathy, overview
-
-
?
additional information
?
-
-
the enzyme is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons, overview
-
-
?
additional information
?
-
-
the enzyme negatively regulates synaptic plasticity and fear learning in the lateral nucleus of the amygdala, the enzyme is involved in memory aquisitoion, rather than in posttraining consolidation of memory, the enzyme may help to prevent aquisition of irrelevant fears, thus enzyme deficiency or defects can lead to pathological fear learning, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + myosin light chain
ADP + myosin light chain phosphate
activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in myosin phosphorylation and enzyme secretion
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
involved in muscle contractility and motility of non-muscle cells
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
in airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain is an important step in calcium signalling pathway from the variation of Ca2+ concentration in cytosol to the force development
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
myyosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
smooth muscle myosin
-
-
?
additional information
?
-
MLCK is a substrate of AMP-activated protein kinase, AMPK
-
-
?
additional information
?
-
-
inhibition of the enzyme retards the growth of prostate cancer cells
-
-
?
additional information
?
-
-
MLCK is probably involved in development of diabetic nephropathy, overview
-
-
?
additional information
?
-
-
the enzyme is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons, overview
-
-
?
additional information
?
-
-
the enzyme negatively regulates synaptic plasticity and fear learning in the lateral nucleus of the amygdala, the enzyme is involved in memory aquisitoion, rather than in posttraining consolidation of memory, the enzyme may help to prevent aquisition of irrelevant fears, thus enzyme deficiency or defects can lead to pathological fear learning, overview
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Calmodulin
-
trypsin or chymotrypsin digested smooth muscle enzyme is independent of Ca2+/calmodulin
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ML-9
-
i.e. 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine, inhibits MLCK and paracellular permeability increases in several intestinal epithelial models
W-7
-
calmodulin/enzyme-specific inhibitor, attenuates cell migration in vivo
ML-7
-
calmodulin/enzyme-specific inhibitor, inhibits cell attachment to extracellular substrate in vivo, attenuates the activation of GTP-binding protein Rac and cell migration
ML-7
-
a specific inhibitor, in vivo the inhibitor enhances the short-term and long-term memory, when applied before fear conditioning, but not immediately afterwards, the inhibitor has no effet on memory retrieval and behaviour when the training stimuli are presented in a non-associative manner
ML-7
-
specific inhibitor of MLCK, in vivo the inhibitor retards the growth of prostate tumours, acts as an adjuvant to etoposide stimulating its ability to prevent growth of established tomours, overview
ML-7
-
specificity, overview, ML-7 changes action potential amplitude and voltage-gated Ca2+ channel current nonspecifically, but does not affect calcimycin-induced release and vesicle readily releasable pool RRP recovery after depletion
ML-7
chemical inhibition of myosin light chain kinase (MLCK) slows down endocytosis
additional information
-
inhibitor effects on enzyme activity in intestinal tissues, overview
-
additional information
-
PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain
-
additional information
-
epilactose induces myosin light chain phosphorylation via MLCK
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
kinetic constants for enzymes from various sources with different myosin light chains as substrates
-
additional information
additional information
-
Michaelis-Menten kinetics, kinetic scheme of the mathematical model considers interactions among Ca2+, calmodulin and MLCK, and the well-known 4-state actomyosin latch bridge model, whereby a link between them is accomplished by the conservation relation of all species of MLCK, detailed overview
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
cMLCK is exclusively expressed in cardic muscle, smMLCK expresses in almost every tissue, including cardiac muscles
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myofibroblast-like stellate cell line, previously called Ito cells, lipocytes, or fat-storing cells
-
expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus
additional information
-
expression analysis of MLCK in healthy and streptozotocin-induced diabetic rats, expression in glomerulus, renal tubule and glomerular arteriolar, glomerulus expression is increased in diabetic rats, overview
-
rat pancreatic and turkey gizzard enzyme are immunologically related
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skeletal muscle expresses a specific MLCK called skeletal-muscle-type myosin light chain kinase, smooth muscle myosin light chain kinase expresses in almost every tissue including skeletal muscles
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smMLCK expresses in almost every tissue, incnluding small intestine
-
smMLCK expresses in almost every tissue, including smooth muscles
additional information
-
myosin light chain kinases in smooth muscle and non-muscle tissues are the same protein
additional information
-
developmental pattern of obscurin and obscurin-associated kinase expression, overview
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
induced endocytosis is slowed by acute inhibition of MLCK and by downregulation of MLCK via RNA interference while the total amount of vesicle exocytosis and somatic Ca2+channel current does not change with MLCK down-regulation. Downregulation of MLCK prevents depolarization-induced phosphorylation of myosin light chain, an effect shared by blockers of Ca2+ channels and calmodulin. Downregulation of MLCK does not decrease the amount of exocytosis
malfunction
MLCK depletion modifies voltage-operated Ca2+ channels. KCl- and AVP-induced Ca2+ signals and voltage-activated Ca2+ current are decreased in MLCK-depleted A7r5 cells. MLCK enzyme inhibition leads to a significant inhibition of cytosolic Ca2+ increase (64%) and contraction induced by 50 mM KCl (92%). Phenotype, detailed overview. Voltage-dependent Ca2+ channel gene expression is decreased by MLCK downregulation
physiological function
-
MLCK phosphorylates myosin regulatory light chain and controls muscle contraction of skeletal muscle, smooth muscle, and cardiac muscle
physiological function
myosin light chain kinase (MLCK) facilitates endocytosis of synaptic vesicles at hippocampal boutons through activity-dependent phosphorylation of myosin downstream of Ca2+/calmodulin. MLCK is an important activity-dependent regulator of vesicle recycling in hippocampal neurons, which are critical for learning and memory. MLCK positively regulates vesicle endocytosis at hippocampal boutons. MLCK regulates endocytosis by functioning between Ca2+/calmodulin and myosin
physiological function
stimulation of vascular smooth muscle cells increases cytosolic Ca2+ concentration as a result of Ca2+ entry from the extracellular space through plasma membrane Ca2+ channels and/or Ca2+ release from intracellular stores via the sarcoplasmic reticulum Ca2+ channels. The increase in Ca2+/calmodulin complex activates myosin light chain kinase (MLCK) triggering contraction, which regulates vasoactivity and blood flow
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). MYLK2_RAT
610
0
65816
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
different molecular weights may be due to high sensitivity to proteolysis during purification
additional information
-
relative masses of various animal skeletal muscle enzymes
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
different molecular weights may be due to high sensitivity to proteolysis during purification
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
-
PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
knockdown of endogenous MLCK by two shRNA sequences: shMLCK1 is 5-GCTAGATTTGACTGCAAGATT-3' and shMLCK 2 is 5'-ACTGTCCTCTATGGCAATGAT-3'
additional information
MLCK is downregulated by transfection with a small interfering RNA targeting MLCK (MLCK-siRNA) in rat small resistance mesenteric artery and in the rat embryonic aortic cell line A7r5. Expression of long (220 kDa) and short (130 kDa) MLCK is inhibited in MLCK-siRNA-transfected cells. Noradrenaline-induced contraction and Ca2+ signal are significantly depressed in MLCK-siRNA compared to scramble-siRNA-transfected small resistance mesenteric artery. Contraction and Ca2+ signal induced by high KCl and voltage-activated Ca2+ current are also significantly decreased in MLCK-siRNAtransfected resistance mesenteric artery
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified to homogeneity from a number of vertebrate muscles and partially purified from non-muscle tissues
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene Myl12b, analysis of MLCK, L-type (CaV1.2), P/Q-type (CaV2.1), and T-type (CaV3.1) voltage-dependent Ca2+ channels and RPL32 mRNA expression by real-time quantitative-PCR
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of myosin light chain kinase protein is rapidly increased by angiotensin II
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Roush, C.L.; Kennelly, P.J.; Glaccum, M.B.; Helfman, D.M.; Scott, J.D.; Krebs, E.G.
Isolation of the cDNA encoding rat skeletal muscle myosin light chain kinase. Sequence and tissue distribution
J. Biol. Chem.
263
10510-10516
1988
Rattus norvegicus (P20689)
Gallagher, P.J.; Herring, B.P.; Griffin, S.A.; Stull, J.T.
Molecular characterization of a mammalian smooth muscle myosin light chain kinase [published erratum appears in J Biol Chem 1992 May 5;267(13):9450]
J. Biol. Chem.
266
23936-23944
1991
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Oryctolagus cuniculus (P29294), Rattus norvegicus
Bissonnette, M.; Kuhn, D.; de Lanerolle, P.
Purification and characterization of myosin light-chain kinase from the rat pancreas
Biochem. J.
258
739-747
1989
Rattus norvegicus
Conti, M.A.; Adelstein, R.S.
Purification and properties of myosin light chain kinases
Methods Enzymol.
196
34-47
1991
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus, Sus scrofa
Stull, J.T.; Nunnally, M.H.; Michnoff, C.H in
Calmoduline-dependent protein kinases
The Enzymes, 3rd. Ed. (Boyer, P. D. , Krebs, E. G. , eds. )
17
113-166
1986
Bos taurus, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus
-
Van Lierop, J.E.; Wilson, D.P.; Davis, J.P.; Tikunova, S.; Sutherland, C.; Walsh, M.P.; Johnson, J.D.
Activation of smooth muscle myosin light chain kinase by calmodulin. Role of Lys30 and Gly40
J. Biol. Chem.
277
6550-6558
2002
Gallus gallus, Rattus norvegicus
Yanase, M.; Ikeda, H.; Ogata, I.; Matsui, A.; Noiri, E.; Tomiya, T.; Arai, M.; Inoue, Y.; Tejima, K.; Nagashima, K.; Nishikawa, T.; Shibata, M.; Ikebe, M.; Rojkind, M.; Fujiwara, K.
Functional diversity between Rho-kinase- and MLCK-mediated cytoskeletal actions in a myofibroblast-like hepatic stellate cell line
Biochem. Biophys. Res. Commun.
305
223-228
2003
Rattus norvegicus
Gu, L.Z.; Hu, W.Y.; Antic, N.; Mehta, R.; Turner, J.R.; de Lanerolle, P.
Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells
Eur. J. Cancer
42
948-957
2006
Mus musculus, Rattus norvegicus
Zhu, H.; Zhang, X.; Zuo, L.; Zhou, Q.; Gui, S.; Wei, W.; Wang, Y.
Expression of myosin light chain kinase in kidney of streptozotocin-induced diabetic rats
Int. J. Mol. Sci.
7
510-518
2006
Rattus norvegicus
-
Tokuoka, H.; Goda, Y.
Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons
J. Neurosci.
26
11606-11614
2006
Rattus norvegicus
Lamprecht, R.; Margulies, D.S.; Farb, C.R.; Hou, M.; Johnson, L.R.; LeDoux, J.E.
Myosin light chain kinase regulates synaptic plasticity and fear learning in the lateral amygdala
Neuroscience
139
821-829
2006
Rattus norvegicus
Horman, S.; Morel, N.; Vertommen, D.; Hussain, N.; Neumann, D.; Beauloye, C.; El Najjar, N.; Forcet, C.; Viollet, B.; Walsh, M.P.; Hue, L.; Rider, M.H.
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
J. Biol. Chem.
283
18505-18512
2008
Mus musculus, Gallus gallus (P11799), Gallus gallus, Rattus norvegicus (P20689)
Borisov, A.B.; Raeker, M.O.; Russell, M.W.
Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells
J. Cell. Biochem.
103
1621-1635
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Fajmut, A.; Brumen, M.
MLC-kinase/phosphatase control of Ca2+ signal transduction in airway smooth muscles
J. Theor. Biol.
252
474-481
2008
Rattus norvegicus
Feighery, L.M.; Cochrane, S.W.; Quinn, T.; Baird, A.W.; OToole, D.; Owens, S.E.; ODonoghue, D.; Mrsny, R.J.; Brayden, D.J.
Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro
Pharm. Res.
25
1377-1386
2008
Homo sapiens, Mus musculus, Mus musculus C57BL/6, Rattus norvegicus
Han, Y.J.; Hu, W.Y.; Piano, M.; de Lanerolle, P.
Regulation of myosin light chain kinase expression by angiotensin II in hypertension
Am. J. Hypertens.
21
860-865
2008
Rattus norvegicus
Takashima, S.
Phosphorylation of myosin regulatory light chain by myosin light chain kinase, and muscle contraction
Circ. J.
73
208-213
2009
Rattus norvegicus
Suzuki, T.; Nishimukai, M.; Takechi, M.; Taguchi, H.; Hamada, S.; Yokota, A.; Ito, S.; Hara, H.; Matsui, H.
The nondigestible disaccharide epilactose increases paracellular Ca absorption via Rho-associated kinase- and myosin light chain kinase-dependent mechanisms in rat small intestines
J. Agric. Food Chem.
58
1927-1932
2010
Rattus norvegicus
Martinsen, A.; Dessy, C.; Morel, N.
Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase
Channels
8
402-413
2014
Rattus norvegicus (D3ZFU9), Rattus norvegicus Wistar (D3ZFU9)
EXTERNAL LINKS (specific for EC-Number 2.7.11.18)
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