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Disease on EC 2.7.11.17 - Ca2+/calmodulin-dependent protein kinase and Organism(s) Homo sapiens and UniProt Accession Q9UQM7

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
CaMK4 Promotes Abortion-related Th17 Cell Imbalance by Activating AKT/mTOR Signaling Pathway.
Acidosis
Acidosis alters the phosphorylation of Ser16 and Thr17 of phospholamban in rat cardiac muscle.
Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis.
Caldesmon and heat shock protein 20 phosphorylation in nitroglycerin- and magnesium-induced relaxation of swine carotid artery.
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Adenocarcinoma
A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression.
Association of pretherapeutic expression of chemotherapy-related genes with response to neoadjuvant chemotherapy in Barrett carcinoma.
Differential expression of high molecular weight caldesmon in colorectal pericryptal fibroblasts and tumour stroma.
Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase.
Smoothelin and caldesmon are reliable markers for distinguishing muscularis propria from desmoplasia: a critical distinction for accurate staging colorectal adenocarcinoma.
The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas.
[Prediction of response to neoadjuvant chemotherapy in Barrett's carcinoma by quantitative gene expression analysis]
Adenoma
Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways.
High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions.
Monoclonal antibodies to cytoskeletal proteins: an immunohistochemical investigation of human colon cancer.
Adenomatoid Tumor
Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases.
Adenoviridae Infections
Gene delivery of l-caldesmon protects cytoskeletal cell membrane integrity against adenovirus infection independently of myosin ATPase and actin assembly.
Albuminuria
Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/?-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria.
Alzheimer Disease
A Comprehensive Analysis of the CaMK2A Gene and Susceptibility to Alzheimer's Disease in the Han Chinese Population.
Calcium/calmodulin-dependent kinase II and Alzheimer's disease.
Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons.
Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway.
Chrysophanol improves memory ability of d-galactose and A?25-35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM-CaMKIV signal pathway in hippocampus.
Development and validation of a sensitive entropy-based measure for the water maze.
Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease.
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.
Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats.
Granisetron Alleviates Alzheimer's Disease Pathology in TgSwDI Mice Through Calmodulin-Dependent Protein Kinase II/cAMP-Response Element Binding Protein Pathway.
Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease.
In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease.
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.
Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.
microRNAs in CNS disorders.
Oligomers of Amyloid ? Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease.
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology.
Amnesia
Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex, and amygdala in response to spatial learning, predator exposure, and stress-induced amnesia.
The involvement of Ca2+/calmodulin-dependent protein kinase in memory formation in day-old chicks.
Amnesia, Retrograde
Intrahippocampal or intraamygdala infusion of KN62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, causes retrograde amnesia in the rat.
Learning-specific, time-dependent increases in hippocampal Ca2+/calmodulin-dependent protein kinase II activity and AMPA GluR1 subunit immunoreactivity.
Stimulators of the cAMP cascade reverse amnesia induced by intra-amygdala but not intrahippocampal KN-62 administration.
Amyloidosis
Proteome analysis of cerebrospinal fluid in Guillain-Barré syndrome (GBS).
Amyotrophic Lateral Sclerosis
Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies.
Postsynaptic Alteration of NR2A Subunit and Defective Autophosphorylation of alphaCaMKII at Threonine-286 Contribute to Abnormal Plasticity and Morphology of Upper Motor Neurons in Presymptomatic SOD1G93A Mice, a Murine Model for Amyotrophic Lateral Sclerosis.
Anemia, Neonatal
Phlebotomy-induced anemia alters hippocampal neurochemistry in neonatal mice.
Angelman Syndrome
Ca2+/Calmodulin-dependent Protein Kinase II? (?CaMKII) Controls the Activity of the Dopamine Transporter: IMPLICATIONS FOR ANGELMAN SYNDROME.
Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.
Arrhythmias, Cardiac
A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.
ADAMTS13 Deficiency Shortens the Life Span of Mice With Experimental Diabetes.
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Effects of Wenxin Keli on Cardiac Hypertrophy and Arrhythmia via Regulation of the Calcium/Calmodulin Dependent Kinase II Signaling Pathway.
KN-93 inhibits IKr in mammalian cardiomyocytes.
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKII?.
Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits.
Regulatory mechanism of calcium/calmodulin-dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review).
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia.
Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase II?c transgenic mice.
Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction.
Asthma
Oxidized CaMKII promotes asthma through the activation of mast cells.
Atherosclerosis
Identification of Four Potential Biomarkers Associated With Coronary Artery Disease in Non-diabetic Patients by Gene Co-expression Network Analysis.
Modulation of human aorta smooth muscle cell phenotype: a study of muscle-specific variants of vinculin, caldesmon, and actin expression.
Atrial Fibrillation
Calcium/calmodulin-dependent protein kinase II causes atrial structural remodeling associated with atrial fibrillation and heart failure.
Autoimmune Diseases
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.
CaMK4 Promotes Abortion-related Th17 Cell Imbalance by Activating AKT/mTOR Signaling Pathway.
CaMK4-dependent activation of AKT/mTOR and CREM-? underlies autoimmunity-associated Th17 imbalance.
The role of CaMK4 in immune responses.
Blister
A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly.
Tropomyosin and caldesmon regulate cytokinesis speed and membrane stability during cell division.
Bone Neoplasms
The inhibitor of calcium/calmodulin-dependent protein kinase II KN93 attenuates bone cancer pain via inhibition of KIF17/NR2B trafficking in mice.
Bone Resorption
Afamin stimulates osteoclastogenesis and bone resorption via Gi-coupled receptor and Ca2+/calmodulin-dependent protein kinase (CaMK) pathways.
Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).
Cav1.3 is upregulated in osteoporosis rat model and promotes osteoclast differentiation from preosteoclast cell line RAW264.7.
Bradycardia
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Brain Diseases
A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly.
Brain Injuries
Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke.
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase ? Is Detrimental in Hypoxia?Ischemia Neonatal Brain Injury.
Ischemic brain injury selectively alters ATP binding of calcium and calmodulin-dependent protein kinase II.
Persistent translocation of Ca2+/calmodulin-dependent protein kinase II to synaptic junctions in the vulnerable hippocampal CA1 region following transient ischemia.
Phosphorylation of calcium calmodulin-dependent protein kinase II following lateral fluid percussion brain injury in rats.
TRPM7 Mediates Neuronal Cell Death Upstream of Calcium/Calmodulin-Dependent Protein Kinase II and Calcineurin Mechanism in Neonatal Hypoxic-Ischemic Brain Injury.
Brain Injuries, Traumatic
Calponin and caldesmon cellular domains in reacting microvessels following traumatic brain injury.
Increased Expression of Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Delta after Rat Traumatic Brain Injury.
Brain Ischemia
Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha) reversibly targets to and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in cerebral ischemia and reperfusion in hippocampus of rats.
Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats.
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Calcium/calmodulin dependent protein kinase II mRNA in the gerbil brain after cerebral ischemia.
Calcium/calmodulin-dependent kinase II facilitated GluR6 subunit serine phosphorylation through GluR6-PSD95-CaMKII signaling module assembly in cerebral ischemia injury.
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
CaMKII in cerebral ischemia.
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
Effect of cerebral ischemia on calcium/calmodulin-dependent protein kinase II activity and phosphorylation.
Glutamate-induced loss of Ca2+/calmodulin-dependent protein kinase II activity in cultured rat hippocampal neurons.
In vivo inhibition of hippocampal Ca2+/calmodulin-dependent protein kinase II by RNA interference.
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase ? and Calcium/Calmodulin-Dependent Protein Kinase IV Is Detrimental in Cerebral Ischemia.
Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains.
Postsynaptic density protein 95 mediates Ca2+/calmodulin-dependent protein kinase II-activated serine phosphorylation of neuronal nitric oxide synthase during brain ischemia in rat hippocampus.
Role of calcium in inactivation of calcium/calmodulin dependent protein kinase II after cerebral ischemia.
Brain Neoplasms
Identification of tumor-related proteins by proteomic analysis of cerebrospinal fluid from patients with primary brain tumors.
Microvascular proliferation of brain metastases mimics glioblastomas in squash cytology.
Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.
Breast Neoplasms
Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer.
Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer.
Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
cGMP-dependent Protein Kinase I? Regulates Breast Cancer Cell Migration and Invasion via a Novel Interaction with the Actin/Myosin-associated Protein Caldesmon.
Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.
Inhibition of the CaM-Kinases Augments Cell Death in Response to Oxygen Radicals and Oxygen Radical Inducing Cancer Therapies in MCF-7 Human Breast Cancer Cells.
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells.
The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer.
Burkitt Lymphoma
A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1.
Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon.
ca2+/calmodulin-dependent protein kinase deficiency
Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.
Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.
Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.
Hypomorphic CAMKK2 in EA.hy926 endothelial cells causes abnormal transferrin trafficking, iron homeostasis and glucose metabolism.
Impaired memory of eyeblink conditioning in CaMKIV KO mice.
Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus.
The Influence of Thyroid Hormone on Ca2+ Signaling Pathways during Embryonal Development.
Carcinogenesis
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem.
Genome wide DNA differential methylation regions in colorectal cancer patients in relation to blood related family members, obese and non-obese controls - a preliminary report.
Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer.
Organelle-derived acetyl-CoA promotes prostate cancer cell survival, migration, and metastasis via activation of calmodulin kinase II.
Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma.
Carcinoma
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma.
CD10 imunostaining does not distinguish endometrial carcinoma invading myometrium from carcinoma involving adenomyosis.
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions.
Identification and purification of Ca2+/calmodulin-dependent protein kinase V from human gastric carcinoma.
Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) .
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
Overexpression of caldesmon is associated with tumor progression in patients with primary non-muscle-invasive bladder cancer.
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas.
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
Thyroid hormone-dependent gene expression in differentiated embryonic stem cells and embryonal carcinoma cells: identification of novel thyroid hormone target genes by deoxyribonucleic acid microarray analysis.
Carcinoma, Endometrioid
CD10 imunostaining does not distinguish endometrial carcinoma invading myometrium from carcinoma involving adenomyosis.
Carcinoma, Hepatocellular
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation.
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins.
Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.
Enhanced expression and activation of Ca(2+)/calmodulin-dependent protein kinase IV in hepatocellular carcinoma.
High molecular weight caldesmon positive stromal cells in the capsule of hepatocellular carcinomas.
Carcinoma, Non-Small-Cell Lung
Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase.
Carcinoma, Ovarian Epithelial
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Carcinoma, Renal Cell
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
Carcinoma, Squamous Cell
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
Cardio-Renal Syndrome
An Overview of the Role of Calcium/Calmodulin-Dependent Protein Kinase in Cardiorenal Syndrome.
Cardiomegaly
?IV-spectrin regulates STAT3 targeting to tune cardiac response to pressure overload.
Activation of the Cardiac Renin-Angiotensin System in High Oxygen-Exposed Newborn Rats: Angiotensin Receptor Blockade Prevents the Developmental Programming of Cardiac Dysfunction.
Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.
CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo.
CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.
CaMKIIdelta orchestrates G protein coupled receptor and electric field stimulation-induced cardiomyocyte hypertrophy.
Cardiac Hypertrophy and Heart Failure Development Through Gq and CaM Kinase II Signaling.
Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy.
Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.
Expression of Ca2+/calmodulin-dependent protein kinase II delta-subunit isoforms in rats with hypertensive cardiac hypertrophy.
Inhibition of cardiac hypertrophy by probiotic-fermented purple sweet potato yogurt in spontaneously hypertensive rat hearts.
Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells.
Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Roles of calcineurin and calcium/calmodulin-dependent protein kinase II in pressure overload-induced cardiac hypertrophy.
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.
The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats.
Type III Transforming Growth Factor-? Receptor Drives Cardiac Hypertrophy Through ?-Arrestin2-Dependent Activation of Calmodulin-Dependent Protein Kinase II.
[Oxidative stress and calcium/calmodulin-dependent protein kinase II contribute to the development of sustained ? adrenergic receptor-stimulated cardiac hypertrophy in rats].
Cardiomyopathies
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.
Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein.
CaMKII as a target for arrhythmia suppression.
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy.
KN-93 inhibits IKr in mammalian cardiomyocytes.
Cardiomyopathy, Dilated
Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.
Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy.
Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic
The Role of Calcium/Calmodulin-Dependent Protein Kinase II Activation in Hypertrophic Cardiomyopathy.
Cardiotoxicity
Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II.
Cardiovascular Diseases
A crucial role of caldesmon in vascular development in vivo.
RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation.
Cerebrovascular Disorders
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Cholera
Ca2+/calmodulin-dependent protein kinase II is an essential mediator in the coordinated regulation of electrocyte Ca2+-ATPase by calmodulin and protein kinase A.
Regulation of phospholipase D and secretion in mast cells by protein kinase A and other protein kinases.
Chorea
A Neurodevelopmental Disorder With Dystonia and Chorea Resulting From Clustering CAMK4 Variants.
Tubulin is a neuronal target of autoantibodies in Sydenham's chorea.
Choriocarcinoma
Calcium/calmodulin-dependent kinase inhibitor induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells.
Retraction Note to: Calcium/calmodulin-dependent kinase inhibitor induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells.
Colitis
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.
Calcium/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis.
CaM kinase II in colonic smooth muscle contributes to dysmotility in murine DSS-colitis.
Changes in the Expression of Smooth Muscle Contractile Proteins in TNBS- and DSS-Induced Colitis in Mice.
Colitis, Ulcerative
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.
Colitis-Associated Neoplasms
CAMK2? in intestinal epithelial cells modulates colitis-associated colorectal carcinogenesis via enhancing STAT3 activation.
Colonic Neoplasms
Ca
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases.
Colorectal Neoplasms
Caldesmon is useful in demonstrating extramural venous invasion in colorectal carcinomas showing mucinous differentiation.
Communicable Diseases
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.
Congenital Hypothyroidism
Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.
Corticobasal Degeneration
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
COVID-19
Complement activation and increased expression of Syk, mucin-1 and CaMK4 in kidneys of patients with COVID-19.
Olfactory Bulb and Amygdala Gene Expression Changes in Subjects Dying with COVID-19.
Cystadenoma
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Cystic Fibrosis
Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase.
Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues.
Death, Sudden, Cardiac
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Dehydration
Abscisic Acid Inhibits Rice Protein Phosphatase PP45 via H2O2 and Relieves Repression of the Ca2+/CaM-Dependent Protein Kinase DMI3.
Thirst recruits phasic dopamine signaling through subfornical organ neurons.
Dementia, Vascular
[The changes of resting [Ca2+]i level and expression of CaM mRNA, CaMPK II mRNA in hippocampal neurons of the mice with vascular dementia].
Dengue
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.
Diabetes Mellitus
Diabetes mellitus affects activity of calcium/calmodulin-dependent protein kinase II alpha in rat trigeminal ganglia.
Sex differences in pain-related behavior and expression of calcium/calmodulin-dependent protein kinase II in dorsal root ganglia of rats with diabetes type 1 and type 2.
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Type 1
Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes.
Caldesmon over-expression in type 1 diabetic nephropathy.
Diabetes Mellitus, Type 2
Cutaneous expression of calcium/calmodulin-dependent protein kinase II in rats with type 1 and type 2 diabetes.
Exendin-4 stimulates autophagy in pancreatic ?-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis.
Expression of Calcium/Calmodulin-Dependent Protein Kinase II and Pain-Related Behavior in Rat Models of Type 1 and Type 2 Diabetes.
Human islets of Langerhans express the delta(C) isoform of calcium/calmodulin-dependent protein kinase II.
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
Role of CaMKII in the regulation of fatty acids and lipid metabolism.
The expression of calcium/calmodulin-dependent protein kinase II in the dorsal horns of rats with type 1 and type 2 diabetes.
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetic Nephropathies
Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes.
Association of rs 3807337 polymorphism of CALD1 gene with diabetic nephropathy occurrence in type 1 diabetes - preliminary results of a family-based study.
Caldesmon over-expression in type 1 diabetic nephropathy.
Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice.
Phenotypic changes of the mesangium in diabetic nephropathy.
Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells.
Diabetic Neuropathies
Expression of Calcium/Calmodulin-Dependent Protein Kinase II and Pain-Related Behavior in Rat Models of Type 1 and Type 2 Diabetes.
Intrathecal inhibition of calcium/calmodulin-dependent protein kinase II in diabetic neuropathy adversely affects pain-related behavior.
The effects of intraganglionic injection of calcium/calmodulin-dependent protein kinase II inhibitors on pain-related behavior in diabetic neuropathy.
Diabetic Retinopathy
Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.
Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas.
Diphtheria
Characterization of Ca2+/calmodulin-dependent protein kinase in rat pancreatic islets.
Heterogeneity of native rat liver elongation factor 2.
Dystonia
A Neurodevelopmental Disorder With Dystonia and Chorea Resulting From Clustering CAMK4 Variants.
Recent genetic advances in early-onset dystonia.
Embolism
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Microsphere embolism-induced changes in noradrenaline release in the cerebral cortex in rats.
Encephalitis
Neurons promote encephalitogenic CD4+ lymphocyte infiltration in experimental autoimmune encephalomyelitis.
Encephalomyelitis
Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice.
Neuronal Ablation of Alpha/Beta Interferon (IFN-?/?) Signaling Exacerbates Central Nervous System Viral Dissemination and Impairs IFN-? Responsiveness in Microglia/Macrophages.
Encephalomyelitis, Autoimmune, Experimental
Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice.
Endometrial Neoplasms
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas.
Endometrial Stromal Tumors
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Endometriosis
Caldesmon: new insights for diagnosing endometriosis.
Endotoxemia
CaMKIV regulates mitochondrial dynamics during sepsis.
Enterocolitis, Necrotizing
Calcium/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis.
Epilepsies, Partial
Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.
Epilepsy
Abnormal changes in voltage-gated sodium channels Na(V)1.1, Na(V)1.2, Na(V)1.3, Na(V)1.6 and in calmodulin/calmodulin-dependent protein kinase II, within the brains of spontaneously epileptic rats and tremor rats.
Altered calcium/calmodulin kinase II activity changes calcium homeostasis that underlies epileptiform activity in hippocampal neurons in culture.
Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy.
Association of UGT2B7 and CaMK4 with response of valproic acid in Chinese children with epilepsy.
Calmodulin-dependent protein kinase II. Multifunctional roles in neuronal differentiation and synaptic plasticity.
Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy.
In vivo inhibition of hippocampal Ca2+/calmodulin-dependent protein kinase II by RNA interference.
Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation.
miR-125a-5p alleviates dysfunction and inflammation of pentylenetetrazol-induced epilepsy through targeting calmodulin-dependent protein kinase IV (CAMK4).
Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity.
Regulation of type-II calmodulin kinase: functional implications.
Reversing nerve cell pathology by optimizing modulatory action on target ion channels.
Severe intellectual disability, absence of language, epilepsy, microcephaly and progressive cerebellar atrophy related to the recurrent de novo variant p.(P139L) of the CAMK2B gene: A case report and brief review.
The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease.
Epilepsy, Temporal Lobe
Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy.
Reversing nerve cell pathology by optimizing modulatory action on target ion channels.
Essential Hypertension
[Association between gene polymorphism of calcium/calmodulin-dependent kinase 4 and efficacy of amlodipine in the treatment of hypertension in Chinese Han nationality].
Fasciitis
Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue.
Fatty Liver
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Fetal Growth Retardation
Expression of von Willebrand factor and caldesmon in the placental tissues of pregnancies complicated with intrauterine growth restriction.
Fetal Resorption
CaMK4 Promotes Abortion-related Th17 Cell Imbalance by Activating AKT/mTOR Signaling Pathway.
Fibroma
Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue.
Monoclonal antibodies against caldesmon, a Ca++/calmodulin- and actin-binding protein of smooth muscle and nonmuscle cells.
Fragile X Syndrome
Ca2+/calmodulin-dependent protein kinase IV links Group I metabotropic glutamate receptors to FMRP in cingulate cortex.
Frontotemporal Lobar Degeneration
The olfactory bulb proteotype differs across frontotemporal dementia spectrum.
Gastrointestinal Stromal Tumors
[Difficulties in diagnosing and treating GIST: report and analysis of a case]
Glaucoma
Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells.
Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments.
Glioblastoma
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
MiR-1271 regulates glioblastoma cell proliferation and invasion by directly targeting the CAMKK2 gene.
Glioma
5-HT2A receptor activation leads to increased BDNF mRNA expression in C6 glioma cells.
Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.
Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.
Calmodulin-dependent protein kinases in rat glioblastoma.
CAMKK2, Regulated by Promoter Methylation, is a Prognostic Marker in Diffuse Gliomas.
Differential expression of splicing variants of the human caldesmon gene (CALD1) in glioma neovascularization versus normal brain microvasculature.
Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells.
Involvement of calcium/calmodulin-dependent protein kinase II in the induction of mPer1.
Low-molecular weight caldesmon as a potential serum marker for glioma.
MiR-1271 regulates glioblastoma cell proliferation and invasion by directly targeting the CAMKK2 gene.
Modulation by calcium/calmodulin-dependent protein kinase II of functional response of delta opioid receptor in neuroblastoma x glioma hybrid (NG108-15) cells.
Phosphorylation of elongation factor 2 in normal and malignant rat glial cells.
Role of calmodulin-dependent phosphorylation of elongation factor 2 in the proliferation of rat glial cells.
Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.
[Regulation of Ca2+/calmodulin-dependent protein kinase II in the cell systems in response to cellular stimuli]
Glomerulonephritis
CaMK4 facilitates the recruitment of IL-17-producing cells to target organs through the CCR6/CCL20 axis in Th17-driven inflammatory diseases.
Enhanced glomerular expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid-heparin therapy.
Enhanced interstitial expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid-heparin therapy.
Glomerulonephritis, IGA
Enhanced glomerular expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid-heparin therapy.
Enhanced interstitial expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid-heparin therapy.
Glomerulosclerosis, Focal Segmental
Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.
CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.
Glomus Tumor
Cytoskeletal characterization of arteriovenous epithelioid cells.
Glucose Intolerance
Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
Hypothalamic CaMKK2 contributes to the regulation of energy balance.
Granulosa Cell Tumor
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Heart Arrest
Isoflurane pretreatment ameliorates postischemic neurologic dysfunction and preserves hippocampal Ca2+/calmodulin-dependent protein kinase in a canine cardiac arrest model.
Heart Diseases
A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.
Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease.
CaMKII: do not work too hard in the failing heart.
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy.
Dysfunctional ryanodine receptors in the heart: New insights into complex cardiovascular diseases.
MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKII?.
PP1? functionally augments the alternative splicing of CaMKII? through interaction with ASF.
Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca(2+) release events in a rodent model of early stage diabetes: The arrhythmogenic substrate.
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Heart Failure
Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy.
Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure.
Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.
Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic ?-Adrenoceptor Blockade in Experimental and Human Heart Failure.
Calcium/calmodulin-dependent protein kinase II causes atrial structural remodeling associated with atrial fibrillation and heart failure.
Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.
Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias.
CaMKII as a target for arrhythmia suppression.
CaMKII in myocardial hypertrophy and heart failure.
CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.
CaMKIIdelta overexpression in hypertrophy and heart failure: cellular consequences for excitation-contraction coupling.
Cardiac Hypertrophy and Heart Failure Development Through Gq and CaM Kinase II Signaling.
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.
Cardiac-specific inhibition of kinase activity in calcium/calmodulin-dependent protein kinase kinase-? leads to accelerated left ventricular remodeling and heart failure after transverse aortic constriction in mice.
Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure.
Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure.
Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure.
Oxidized CaMKII: a "heart stopper" for the sinus node?
Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits.
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure.
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
The Murine Model of Mucopolysaccharidosis IIIB Develops Cardiopathies over Time Leading to Heart Failure.
[Effects of valsartan on myocardial calcium/calmodulin-dependent protein kinase-II expression and activity in a rabbit model of heart failure]
Heart Rupture
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Hepatitis
Neuronal Ablation of Alpha/Beta Interferon (IFN-?/?) Signaling Exacerbates Central Nervous System Viral Dissemination and Impairs IFN-? Responsiveness in Microglia/Macrophages.
Herpes Simplex
Inhibition of calmodulin-dependent kinase kinase blocks human cytomegalovirus-induced glycolytic activation and severely attenuates production of viral progeny.
Transient viral-mediated overexpression of alpha-calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell leads to long-lasting functional upregulation of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors: dopamine type-1 receptor and protein kinase A dependence.
Herpes Zoster
Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.
Structural requirements for calmodulin binding to membrane-associated guanylate kinase homologs.
Hyperalgesia
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia.
Dezocine attenuates the remifentanil-induced postoperative hyperalgesia by inhibition of phosphorylation of CaMK??.
Formalin-induced spinal cord calcium/calmodulin-dependent protein kinase II alpha expression is modulated by heme oxygenase in mice.
Growth Arrest and DNA-damage-inducible Protein 45?-mediated DNA Demethylation of Voltage-dependent T-type Calcium Channel 3.2 Subunit Enhances Neuropathic Allodynia after Nerve Injury in Rats.
Inhibition of CaMKIV relieves streptozotocin-induced diabetic neuropathic pain through regulation of HMGB1.
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
Nicotine reward and affective nicotine withdrawal signs are attenuated in calcium/calmodulin-dependent protein kinase IV knockout mice.
Phosphorylated CaMKII levels increase in rat central nervous system after large-dose intravenous remifentanil.
Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia.
Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation.
Wnt5b/Ryk-mediated membrane trafficking of P2X3 receptors contributes to bone cancer pain.
Hyperglycemia
CaM Kinase II-? Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy.
Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.
Hyperhomocysteinemia
Camk2b protects neurons from homocysteine-induced apoptosis with the involvement of HIF-1? signal pathway.
Hyperkalemia
Works on heart, how about brain? Effect of hyperkalemia on focal cerebral ischemia/reperfusion injury in rats.
Hyperkinesis
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder.
Hypersensitivity
Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons.
Hypertension
Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function.
CaMK4 Gene Deletion Induces Hypertension.
CAMK4 gene variation is associated with hypertension in a Uygur population.
Functional significance of activation of calcium/calmodulin-dependent protein kinase II in angiotensin II--induced vascular hyperplasia and hypertension.
Inhibition of cardiac hypertrophy by probiotic-fermented purple sweet potato yogurt in spontaneously hypertensive rat hearts.
Mitochondrial fission protein, dynamin-related protein 1, contributes to the promotion of hypertensive cardiac hypertrophy and fibrosis in Dahl-salt sensitive rats.
Oxidized CaMKII: a "heart stopper" for the sinus node?
Redox-sensitive calcium/calmodulin-dependent protein kinase II? in angiotensin II intra-neuronal signaling and hypertension.
Role of calcium/calmodulin-dependent protein kinases in expression of Fos protein in the nucleus tractus solitarii after sustained hypertension.
[Association between gene polymorphism of calcium/calmodulin-dependent kinase 4 and efficacy of amlodipine in the treatment of hypertension in Chinese Han nationality].
Hypertension, Renal
[Effects of qishenyiqi gutta pills on calcium/calmodulin dependent protein kinase II in rats with renal hypertension].
Hyperthyroidism
Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.
Thyroid hormone downregulates the expression and function of sarcoplasmic reticulum-associated CaM kinase II in the rabbit heart.
Hypertrophy, Left Ventricular
The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats.
Hypothyroidism
A critical role of CREB in the impairment of late-phase LTP by adult onset hypothyroidism.
Chronic Nicotine Treatment Reverses Hypothyroidism-Induced Impairment of L-LTP Induction Phase: Critical Role of CREB.
Developmental Iodine Deficiency and Hypothyroidism Impair Spatial Memory in Adolescent Rat Hippocampus: Involvement of CaMKII, Calmodulin and Calcineurin.
Developmental Iodine Deficiency and Hypothyroidism Reduce Phosphorylation of Calcium/Calmodulin-Dependent Kinase II in the Rat Entorhinal Cortex.
Effect of hypothyroidism on the subcellular distribution of Ca2+/calmodulin-stimulated protein kinase II in chicken brain during posthatch development.
Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats.
Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.
Late Maternal Hypothyroidism Alters the Expression of Camk4 in Neocortical Subplate Neurons: A Comparison with Nurr1 Labeling.
Levothyroxin replacement therapy restores hypothyroidism induced impairment of L-LTP induction: critical role of CREB.
The Influence of Thyroid Hormone on Ca2+ Signaling Pathways during Embryonal Development.
[Effect of iodine deficiency and hypothyroidism on the protein expressions of CaMK II in the hippocampus of pups]
Hypoxia, Brain
Binding studies and biological evaluation of ?-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV.
Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Effect of hypoxia on calcium influx and calcium/calmodulin-dependent kinase activity in cortical neuronal nuclei of the guinea pig fetus during development.
Effect of hypoxia on protein phosphatase 2A activity, subcellular distribution and expression in cerebral cortex of newborn piglets.
Infarction, Middle Cerebral Artery
Calcium/calmodulin-dependent protein kinase kinase ? is neuroprotective in stroke in aged mice.
Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion.
Simvastatin Pretreatment Protects Cerebrum from Neuronal Injury by Decreasing the Expressions of Phosphor-CaMK II and AQP4 in Ischemic Stroke Rats.
Infections
A dominant function of CCaMK in intracellular accommodation of bacterial and fungal endosymbionts.
A novel interaction between CCaMK and a protein containing the Scythe_N ubiquitin-like domain in Lotus japonicus.
A Role for the Non-Canonical Wnt-?-Catenin and TGF-? Signaling Pathways in the Induction of Tolerance during the Establishment of a Salmonella enterica Serovar Enteritidis Persistent Cecal Infection in Chickens.
Activation of calcium- and calmodulin-dependent protein kinase (CCaMK), the central regulator of plant root endosymbiosis.
Alteration of Leishmania donovani infection levels by selective impairment of macrophage signal transduction.
Alteration of microRNA-4474/4717 expression and CREB-binding protein in human colorectal cancer tissues infected with Fusobacterium nucleatum.
Anti-echinococcal effect of verapamil involving the regulation of the calcium/calmodulin-dependent protein kinase II response in vitro and in a murine infection model.
Calcium spiking patterns and the role of the calcium/calmodulin-dependent kinase CCaMK in lateral root base nodulation of Sesbania rostrata.
Capsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2.
Cellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A protein.
Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress.
CYCLOPS, a mediator of symbiotic intracellular accommodation.
Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit to Drive Glycolytic Activation and Support Productive Viral Infection.
Negative regulation of CCaMK is essential for symbiotic infection.
Nod Factor-Independent Nodulation in Aeschynomene evenia Required the Common Plant-Microbe Symbiotic Toolkit.
Nuclear-Localized and Deregulated Calcium- and Calmodulin-Dependent Protein Kinase Activates Rhizobial and Mycorrhizal Responses in Lotus japonicus.
PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement.
Porcine Circovirus Type 2 Activates CaMMK? to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium.
Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brain.
Rhizobial and Fungal Symbioses Show Different Requirements for Calmodulin Binding to Calcium Calmodulin-Dependent Protein Kinase in Lotus japonicus.
Rhizobial infection does not require cortical expression of upstream common symbiosis genes responsible for the induction of Ca(2+) spiking.
Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction.
Root Hair Deformation of Symbiosis-Deficient Mutants of Lotus japonicus by Application of Nod Factor from Mesorhizobium loti.
The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models.
The independent acquisition of plant root nitrogen-fixing symbiosis in Fabids recruited the same genetic pathway for nodule organogenesis.
Transient overexpression of alpha-Ca2+/calmodulin-dependent protein kinase II in the nucleus accumbens shell enhances behavioral responding to amphetamine.
Infertility, Male
Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV.
Novel mutations in calcium/calmodulin-dependent protein kinase IV (CAMK4) gene in infertile men.
Influenza, Human
Human host factors required for influenza virus replication.
Transcriptomic signatures of cellular and humoral immune responses in older adults after seasonal influenza vaccination identified by data-driven clustering.
Insulin Resistance
Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects.
Ca2+/calmodulin-dependent protein kinase IV attenuates inflammation and mitochondrial dysfunction under insulin resistance in C2C12 cells.
CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice.
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
Hypothalamic CaMKK2 contributes to the regulation of energy balance.
In vitro treatment of 3?T3-L1 adipocytes with recombinant Calcium/calmodulin-dependent Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTOR/CREB signaling pathway.
Intravenous sustained-release nifedipine ameliorates nonalcoholic fatty liver disease by restoring autophagic clearance.
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
The cholesterol-lowering agent methyl-?-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice.
Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress.
Insulinoma
Ca2+/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells.
Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.
Cloning from insulinoma cells of synapsin I associated with insulin secretory granules.
Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.
Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles.
Overexpression of calcium/calmodulin-dependent protein kinase II in insulinoma cells by use of a retroviral vector.
Regulation of insulin secretion by overexpression of Ca2+/calmodulin-dependent protein kinase II in insulinoma MIN6 cells.
Intellectual Disability
A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly.
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder.
Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice.
Calcium/calmodulin-dependent serine protein kinase and mental retardation.
CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.
Fragile X Mental Retardation Protein and Dendritic Local Translation of the Alpha Subunit of the Calcium/Calmodulin-Dependent Kinase II Messenger RNA Are Required for the Structural Plasticity Underlying Olfactory Learning.
Role of calcium/calmodulin-dependent kinase 2 in neurodevelopmental disorders.
Severe intellectual disability, absence of language, epilepsy, microcephaly and progressive cerebellar atrophy related to the recurrent de novo variant p.(P139L) of the CAMK2B gene: A case report and brief review.
The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function.
Ischemic Attack, Transient
Baclofen is neuroprotective and prevents loss of calcium/calmodulin-dependent protein kinase II immunoreactivity in the ischemic gerbil hippocampus.
Calcium/calmodulin dependent protein kinase II mRNA in the gerbil brain after cerebral ischemia.
Transient cerebral ischemia decreases calcium/calmodulin-dependent protein kinase II immunoreactivity, but not mRNA levels in the gerbil hippocampus.
Kidney Diseases
Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
CaMK4 facilitates the recruitment of IL-17-producing cells to target organs through the CCR6/CCL20 axis in Th17-driven inflammatory diseases.
Leiomyoma
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Large primary leiomyoma causing progressive cervical deformity.
Ossified soft tissue leiomyoma in a patient with sickle cell anemia.
Subungual Leiyomyoma Presenting as Erythronychia: Case Report and Review of the Literature
Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal.
Leiomyosarcoma
A tale of two clones: Caldesmon staining in the differentiation of cutaneous spindle cell neoplasms.
h-Caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrial stromal sarcoma.
Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases.
Primary leiomyosarcoma of the pancreas: report of a case treated by local excision and review of the literature.
Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract.
Rare case of primary leiomyosarcoma of sigmoid mesocolon.
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity.
Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa.
Leukemia
A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.
Ca2+/calmodulin-dependent Protein Kinases in Leukemia Development.
Calmodulin-dependent protein kinase II mediates signal transduction in apoptosis.
CAMKs support development of acute myeloid leukemia.
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Non-selective cation channel-mediated Ca2+-entry and activation of Ca2+/calmodulin-dependent kinase II contribute to G2/M cell cycle arrest and survival of irradiated leukemia cells.
Phosphorylation of CD20 in cells from a hairy cell leukemia cell line. Evidence for involvement of calcium/calmodulin-dependent protein kinase II.
Tumor cell resistance to topoisomerase II poisons: role for intracellular free calcium in the sensitization by inhibitors or calcium-calmodulin-dependent enzymes.
Leukemia, Hairy Cell
Phosphorylation of CD20 in cells from a hairy cell leukemia cell line. Evidence for involvement of calcium/calmodulin-dependent protein kinase II.
Leukemia, Lymphoid
Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.
Research progress on neurobiology of neuronal nitric oxide synthase.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Leukemia, Myeloid
Activated Ca2+/calmodulin-dependent protein kinase IIgamma is a critical regulator of myeloid leukemia cell proliferation.
Ca2+/calmodulin-dependent Protein Kinases in Leukemia Development.
CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells.
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells.
Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors.
The retinoic acid receptor/CaMKII interaction: Pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells.
Leukemia, Myeloid, Acute
A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.
Leukocytosis
CAMK2G is identified as a novel therapeutic target for myelofibrosis.
Liver Diseases
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Liver Neoplasms
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli.
MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).
The camKK2/camKIV relay is an essential regulator of hepatic cancer.
Lung Neoplasms
Association of calcium/calmodulin-dependent protein kinase kinase1 rs7214723 polymorphism with lung cancer risk in a Chinese population.
Ca2+/calmodulin-dependent protein kinase II? enhances stem-like traits and tumorigenicity of lung cancer cells.
Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase.
Polymorphism rs7214723 in CAMKK1 and lung cancer risk in Chinese population.
The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.
Upregulation of cytoskeleton protein and extracellular matrix protein induced by stromal-derived nitric oxide promotes lung cancer invasion and metastasis.
Lupus Erythematosus, Systemic
Calcium/calmodulin-dependent protein kinase 4 promotes GLUT1-dependent glycolysis in systemic lupus erythematosus.
Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Lupus.
Comparative transcriptome analysis reveals a potential role for CaMK4 in ??T17 cells from systemic lupus erythematosus patients with lupus nephritis.
Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.
KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3(+) regulatory T cells in MRL/lpr mice.
Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV.
TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.
The role of CaMK4 in immune responses.
Lupus Nephritis
CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
Comparative transcriptome analysis reveals a potential role for CaMK4 in ??T17 cells from systemic lupus erythematosus patients with lupus nephritis.
Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.
Gene-function studies in SLE.
Gene-function studies in systemic lupus erythematosus.
Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.
TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.
Lymphatic Metastasis
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases.
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
Lymphoma
A case report of tracheal inflammatory myofibroblastic tumor in a 34-week pregnant woman misdiagnosed with asthma.
Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas.
Inflammatory myofibroblastic tumors of the urinary tract: a clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma.
Nodular Fasciitis of External Auditory Canal.
Reactive nodular fibrous pseudotumor: A first report of gastric localization and clinicopathologic review.
The immunohistochemical profile of oral inflammatory myofibroblastic tumors.
The role of caldesmon in the regulation of receptor capping in mouse T-lymphoma cell.
Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor: A case report and review of the literature.
[Inflammatory myofibroblastic tumor of bladder: a clinicopathologic study of five cases]
Lymphoma, B-Cell
Calcium/calmodulin-dependent protein kinase kinase ? is neuroprotective in stroke in aged mice.
Lymphoma, Follicular
Differential expression of Ca(2+)-binding proteins on follicular dendritic cells in non-neoplastic and neoplastic lymphoid follicles.
Malaria, Cerebral
CaM kinase II-alpha activity, levels and Ca/calmodulin dependent phosphorylation of substrate proteins in mice brain during fatal murine cerebral malaria.
Massive Hepatic Necrosis
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
Measles
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling.
Medulloblastoma
Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.
Melanoma
CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK?NRF2 Pathway.
Memory Disorders
Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain Amyloidosis.
Modulation of hippocampal dopamine and synapse-related proteins by electroacupuncture improves memory deficit caused by sleep deprivation.
Neural Activity Changes Underlying the Working Memory Deficit in Alpha-CaMKII Heterozygous Knockout Mice.
Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging.
Mental Retardation, X-Linked
Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice.
CASK mutations are frequent in males and cause X-linked nystagmus and variable XLMR phenotypes.
Microcephaly
A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly.
CASK mutations are frequent in males and cause X-linked nystagmus and variable XLMR phenotypes.
MICrocephaly, disproportionate pontine and cerebellar hypoplasia syndrome: A clinico-radiologic phenotype linked to calcium/calmodulin-dependent serine protein kinase gene mutation.
Severe intellectual disability, absence of language, epilepsy, microcephaly and progressive cerebellar atrophy related to the recurrent de novo variant p.(P139L) of the CAMK2B gene: A case report and brief review.
Microphthalmos
Robotic wedge resection of a rare gastric perivascular epithelioid cell tumor: A case report.
Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum.
Migraine Disorders
Mutated CaV2.1 channels dysregulate CASK/P2X3 signaling in mouse trigeminal sensory neurons of R192Q Cacna1a knock-in mice.
Migraine with Aura
Mutated CaV2.1 channels dysregulate CASK/P2X3 signaling in mouse trigeminal sensory neurons of R192Q Cacna1a knock-in mice.
Mononeuropathies
Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy.
Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy.
Movement Disorders
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder.
Multiple Myeloma
CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti-PD-L1 Treatment.
Muscle Neoplasms
A study of ?5 chain of collagen IV, caldesmon, placental alkaline phosphatase and smoothelin as immunohistochemical markers of gastrointestinal smooth muscle neoplasms.
Muscle Spasticity
Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage.
Muscular Atrophy
Targeted ablation of p38? MAPK suppresses denervation-induced muscle atrophy.
The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis.
Muscular Diseases
CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation.
Muscular Dystrophy, Duchenne
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation.
Mycoses
A dominant function of CCaMK in intracellular accommodation of bacterial and fungal endosymbionts.
Myocardial Infarction
Calcium/Calmodulin-Dependent Protein Kinase II Delta Inhibition and Ventricular Remodeling After Myocardial Infarction: A Randomized Clinical Trial.
CaMKII as a target for arrhythmia suppression.
IK1 channel agonist zacopride suppresses ventricular arrhythmias in conscious rats with healing myocardial infarction.
Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction.
Myocardial Ischemia
Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70.
Myoepithelioma
Myoepithelioma breast: clinically masquerading as breast carcinoma.
Myopericytoma
Intracranial myopericytoma: a tumour in a rare location.
Myosarcoma
Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract.
Nasal Polyps
Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps.
Nasopharyngeal Carcinoma
Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma.
Neoplasm Metastasis
Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells.
Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.
CASK regulates Notch pathway and functions as a tumor promoter in pancreatic cancer.
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases.
Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein.
miR-378c suppresses Wilms tumor development via negatively regulating CAMKK2.
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells.
Proteomic Tissue-Based Classifier for Early Prediction of Prostate Cancer Progression.
The dysregulated expression and functional effect of CaMK2 in cancer.
Upregulation of cytoskeleton protein and extracellular matrix protein induced by stromal-derived nitric oxide promotes lung cancer invasion and metastasis.
Neoplasms
"Pediatric-type" Gastrointestinal Stromal Tumors in Adults: Distinctive Histology Predicts Genotype and Clinical Behavior.
14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2).
A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion.
A clonal translocation (7;8)(p13;q11.2) in a leiomyoma of the vulva.
A crucial role of caldesmon in vascular development in vivo.
A giant mesentery malignant solitary fibrous tumor recurring as dedifferentiated liposarcoma- a report of a very rare case and literature review.
A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression.
A tale of two clones: Caldesmon staining in the differentiation of cutaneous spindle cell neoplasms.
Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways.
Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma.
Alteration of microRNA-4474/4717 expression and CREB-binding protein in human colorectal cancer tissues infected with Fusobacterium nucleatum.
AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.
Androgen Receptor Expression in Adenoid Cystic Carcinoma of Breast: A Subset of Seven Cases.
Anticancer and Cytotoxic activities of [Cu(C6H16N2O2)2][Ni(CN)4] and [Cu(C6H16N2O2)Pd(CN)4] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines.
Association of pretherapeutic expression of chemotherapy-related genes with response to neoadjuvant chemotherapy in Barrett carcinoma.
Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma".
Bacoside A Induces Tumor Cell Death in Human Glioblastoma Cell Lines through Catastrophic Macropinocytosis.
Binding studies and biological evaluation of ?-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV.
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma.
Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt.
Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology.
Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.
Caldesmon: Biochemical and Clinical Implications in Cancer.
Calmodulin-dependent protein kinase II mediates signal transduction in apoptosis.
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.
CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation.
CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer.
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK?NRF2 Pathway.
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem.
CD34-positive stromal cells and alpha-smooth muscle actin-positive stromal cells in the tumor capsule of skin sweat gland neoplasms.
Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation.
Characterization of the leiomyomatous variant of myofibroblastoma: a rare subset distinct from other smooth muscle tumors of the breast.
Clinicopathologic study of primary malignant gastrointestinal stromal tumor of the stomach, with special reference to prognostic factors: analysis of results in 140 surgically resected patients.
Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroups.
Comparative kinome analysis to identify putative colon tumor biomarkers.
Concurrent occurrence of primary intracranial Epstein-Barr virus-associated leiomyosarcoma and Hodgkin lymphoma in a young adult.
Deciphering the Role of Protein Kinase D1 (PKD1) in Cellular Proliferation.
Dermatofibrosarcoma Protuberans-Like Tumor With COL1A1 Copy Number Gain in the Absence of t(17;22).
Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Differential expression of Hela-type caldesmon in tumour neovascularization: a new marker of angiogenic endothelial cells.
Differential expression of high molecular weight caldesmon in colorectal pericryptal fibroblasts and tumour stroma.
Differential involvement of calmodulin-dependent protein kinase II-activated AP-1 and c-Jun N-terminal kinase-activated EGR-1 signaling pathways in tumor necrosis factor-alpha and lipopolysaccharide-induced CD44 expression in human monocytic cells.
Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.
Downregulation of delta CaM kinase II in human tumor cells.
Effect of pH on the structure, function, and stability of human calcium/calmodulin-dependent protein kinase IV: combined spectroscopic and MD simulation studies.
Enhanced expression and activation of Ca(2+)/calmodulin-dependent protein kinase IV in hepatocellular carcinoma.
Epithelioid Glomus Tumor of the Uterine Cervix: A Case Report and Review.
Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK.
Epstein-Barr virus associated smooth muscle tumors. Synchronous liver and lung involvement.
Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling.
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice.
Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer.
Fibroblasts play a potential role in bone destruction via osteopontin related caldesmon expression and polymerization in human non-functioning pituitary adenomas.
Fibronexus in "malignant fibrous histiocytoma" of the bone: a case report of pleomorphic myofibrosarcoma.
Gastric Plexiform Fibromyxoma: A Great Mimic of Gastrointestinal Stromal Tumor (GIST) and Diagnostic Pitfalls.
Genome-wide disease association study in chewing tobacco associated oral cancers.
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
h-Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors.
h-Caldesmon as a specific marker of smooth muscle cell differentiation in some soft tissue tumors of the skin.
Hela l-CaD is implicated in the migration of endothelial cells/endothelial progenitor cells in human neoplasms.
Hesperidin-CAMKIV interaction and its impact on cell proliferation and apoptosis in the human hepatic carcinoma and neuroblastoma cells.
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions.
High throughput screening, docking and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases.
Identification of an N-terminal amino acid of the CLC-3 chloride channel critical in phosphorylation-dependent activation of a CaMKII-activated chloride current.
Identification of Potential Inhibitors of Calcium/Calmodulin-Dependent Protein Kinase IV from Bioactive Phytoconstituents.
Implication and Regulation of AMPK during Physiological and Pathological Myeloid Differentiation.
Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up.
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling.
Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells.
Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.
Intraarticular Nodular Fasciitis-A Rare Lesion: Clinicopathologic Analysis of a Series.
Ketamine inhibits aerobic glycolysis in colorectal cancer cells by blocking the NMDA receptor-CaMK II-c-Myc pathway.
Large primary leiomyoma causing progressive cervical deformity.
Leiomyoblastoma of the uterus: an immunohistochemical and electron microscopic study of distinctive tumours with immature smooth muscle cell differentiation mimicking fetal uterine myocytes.
Leiomyosarcoma of the broad ligament with osteoclast-like giant cells and rhabdoid cells.
Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease.
Low-grade sinonasal sarcoma with neural and myogenic features-diagnostic challenge and pathogenic insight.
Malignant myoepithelioma of the breast.
Mesenchymal stem cells regulate cytoskeletal dynamics and promote cancer cell invasion through low dose nitric oxide.
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
MicroRNA-224 and its target CAMKK2 synergistically influence tumor progression and patient prognosis in prostate cancer.
Microvascular proliferation of brain metastases mimics glioblastomas in squash cytology.
MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).
miR-378c suppresses Wilms tumor development via negatively regulating CAMKK2.
Monoclonal antibodies to cytoskeletal proteins: an immunohistochemical investigation of human colon cancer.
Myofibrosarcoma of the bone: a clinicopathologic study.
Myxoid endometrial stromal sarcoma: report of two cases with emphasis on its diagnostic problems.
Nodular Fasciitis of External Auditory Canal.
Novel SRF-ICA1L Fusions in Cellular Myoid Neoplasms With Potential For Malignant Behavior.
Overexpression of caldesmon is associated with tumor progression in patients with primary non-muscle-invasive bladder cancer.
Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways.
Parotid Gland Solitary Fibrous Tumor: A Case Report and Clinicopathologic Review of 22 Cases from the Literature.
Perivascular Epithelioid Cell Tumor of the Urinary Bladder: A Systematic Review.
Perivascular Epithelioid Cell Tumor of the Uterus with Ovarian Involvement: A Case Report and Review of the Literature.
Perivascular epithelioid cell tumour of the vagina in an 8 year old girl.
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Phosphorylation of tyrosine hydroxylase on at least three sites in rat pheochromocytoma PC12 cells treated with 56 mM K+: determination of the sites on tyrosine hydroxylase phosphorylated by cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases.
Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice.
Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases.
Plexiform angiomyxoid myofibroblastic tumor of the stomach: A case report.
Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.
Primary Leiomyosarcoma of the Ovarian Vein.
Primary leiomyosarcoma of the pancreas: report of a case treated by local excision and review of the literature.
Primary pure spindle cell carcinoma (sarcomatoid carcinoma) of the ovary: A case report with immunohistochemical study.
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy.
Proteasome inhibitors induce AMPK activation via CaMKK? in human breast cancer cells.
Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract.
Rare case of primary leiomyosarcoma of sigmoid mesocolon.
Recombinant human tumor necrosis factor alpha induces calcium oscillation and calcium-activated chloride current in human neutrophils. The role of calcium/calmodulin-dependent protein kinase.
Robotic wedge resection of a rare gastric perivascular epithelioid cell tumor: A case report.
Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum.
Smooth muscle actin expression in primary bone tumours.
Smoothelin and caldesmon are reliable markers for distinguishing muscularis propria from desmoplasia: a critical distinction for accurate staging colorectal adenocarcinoma.
Spindle cell rhabdomyosarcoma in adults.
Spindle cell/sclerosing rhabdomyosarcoma: case series from a single institution emphasizing morphology, immunohistochemistry and follow-up.
Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.
Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal.
Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas.
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.
The camKK2/camKIV relay is an essential regulator of hepatic cancer.
The dysregulated expression and functional effect of CaMK2 in cancer.
The effect of phorbol esters on the expression of mRNA for the alpha subunit of calcium/calmodulin dependent protein kinase II in rabbit renal proximal tubules.
The Pathway to Cancer Cachexia: MicroRNA-Regulated Networks in Muscle Wasting Based on Integrative Meta-Analysis.
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
True hemangiopericytoma of the nasal cavity.
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells.
Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor: A case report and review of the literature.
Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer.
Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2.
Uterine myxoid leiomyosarcoma with widespread metastases in a cat.
Uterine retiform sertoli-leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors.
[A case of primary leiomyosarcoma of tibia with multiple skeletal metastases]
[Clinicopathological characterization of primary pulmonary and tracheal glomus tumors].
[Difficulties in diagnosing and treating GIST: report and analysis of a case]
[Gastrointestinal glomus tumors: a clinicopathological analysis of fifteen cases].
[Inflammatory myofibroblastic tumor of bladder: a clinicopathologic study of five cases]
[LEIOMYOSARCOMA ARISING FROM THE RENAL VEIN].
[Mesenchymal uterine tumors. Leiomyomas]
[Prediction of response to neoadjuvant chemotherapy in Barrett's carcinoma by quantitative gene expression analysis]
Nephritis
Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.
IL-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation.
Inhibition of calcium/calmodulin-dependent protein kinase type IV results in suppression of autoimmunity and organ pathology in lupus-prone mice.
Nephrotic Syndrome
Inhibition of calcium(2+)/calmodulin-dependent protein kinase type IV ameliorates experimental nephrotic syndrome.
Nervous System Diseases
A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.
A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly.
CaM kinase II-alpha activity, levels and Ca/calmodulin dependent phosphorylation of substrate proteins in mice brain during fatal murine cerebral malaria.
Characterisation of the interaction between syndecan-2, neurofibromin and CASK: dependence of interaction on syndecan dimerization.
Neuralgia
Anti-hyperalgesic effect of CaMKII inhibitor is associated with downregulation of phosphorylated CREB in rat spinal cord.
Ca(2+)/calmodulin-protein kinase IIalpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection.
Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury.
Cell signaling and the genesis of neuropathic pain.
Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain.
Inhibition of CaMKIV relieves streptozotocin-induced diabetic neuropathic pain through regulation of HMGB1.
Phosphorylated neuronal nitric oxide synthase in neuropathic pain in rats.
PSD95 gene specific siRNAs attenuate neuropathic pain through modulating neuron sensibility and postsynaptic CaMKII? phosphorylation.
The cumulative analgesic effect of repeated electroacupuncture involves synaptic remodeling in the hippocampal CA3 region.
[Effect of Electroacupuncture Intervention on CaMK II-CREB Pathway in Spinal Cord in Rats with Spared Nerve Injury].
Neuroblastoma
131I-MIBG targeting of neuroblastoma cells is acutely enhanced by KCl stimulation through the calcium/calmodulin-dependent kinase pathway.
Ca(2+)-independent activity of Ca(2+)/calmodulin-dependent protein kinase II involved in stimulation of neurite outgrowth in neuroblastoma cells.
Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells.
Calcium activation of ERK mediated by calmodulin kinase I.
Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells.
Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis.
CaMK-II modulation of GABA(A) receptors expressed in HEK293, NG108-15 and rat cerebellar granule neurons.
Characterization of 5' flanking region of alpha isoform of rat Ca2+/calmodulin-dependent protein kinase II gene and neuronal cell type specific promoter activity.
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Functional identification of the promoter for the gene encoding the alpha subunit of calcium/calmodulin-dependent protein kinase II.
Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpiperazin e (KN-62).
Interaction of Arc with CaM kinase II and stimulation of neurite extension by Arc in neuroblastoma cells expressing CaM kinase II.
Investigation of the Ca(2+)-independent form of Ca(2+)/calmodulin-dependent protein kinase II in neurite outgrowth.
Modulation by calcium/calmodulin-dependent protein kinase II of functional response of delta opioid receptor in neuroblastoma x glioma hybrid (NG108-15) cells.
Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.
Neurite outgrowth of neuroblastoma cells overexpressing alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II-effects of protein kinase inhibitors.
Overexpression of Ca2+/calmodulin-dependent protein kinase II in Neuro2a and NG108-15 neuroblastoma cell lines promotes neurite outgrowth and growth cone motility.
Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells.
Retinoic acid stimulates alpha-CAMKII gene expression in PC12 cells at a distinct transcription initiation site.
[Regulation of Ca2+/calmodulin-dependent protein kinase II in the cell systems in response to cellular stimuli]
Neurodegenerative Diseases
Calcium and neuronal cytoskeletal proteins: alterations with aging.
Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Effect of pH on the structure, function, and stability of human calcium/calmodulin-dependent protein kinase IV: combined spectroscopic and MD simulation studies.
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
High throughput screening, docking and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Identification of Potential Inhibitors of Calcium/Calmodulin-Dependent Protein Kinase IV from Bioactive Phytoconstituents.
Utilizing an Animal Model to Identify Brain Neurodegeneration-Related Biomarkers in Aging.
Neurologic Manifestations
Isoflurane pretreatment ameliorates postischemic neurologic dysfunction and preserves hippocampal Ca2+/calmodulin-dependent protein kinase in a canine cardiac arrest model.
Non-alcoholic Fatty Liver Disease
Intravenous sustained-release nifedipine ameliorates nonalcoholic fatty liver disease by restoring autophagic clearance.
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Obesity
Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects.
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
Dietary restriction in the periconceptional period in normal-weight or obese ewes results in increased abundance of angiotensin-converting enzyme (ACE) and angiotensin type 1 receptor (AT1R) in the absence of changes in ACE or AT1R methylation in the adrenal of the offspring.
Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse.
Genome wide DNA differential methylation regions in colorectal cancer patients in relation to blood related family members, obese and non-obese controls - a preliminary report.
Hypothalamic CaMKK2 contributes to the regulation of energy balance.
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Obesity and ischemic stroke modulate the methylation levels of KCNQ1 in white blood cells.
Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.
Role of CaMKII in the regulation of fatty acids and lipid metabolism.
Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Obstetric Labor, Premature
Role of ERK1/2 in uterine contractility and preterm labor in rats.
Optic Atrophy
CASK mutations are frequent in males and cause X-linked nystagmus and variable XLMR phenotypes.
Osteoarthritis
Altered Wnt and NF-?B Signaling in Facet Joint Osteoarthritis: Insights from RNA Deep Sequencing.
CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGF? and BMP through SMAD signaling.
Systemic inhibition or global deletion of CaMKK2 protects against post-traumatic osteoarthritis.
Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.
Osteoporosis
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
Inhibition of CaMKK2 reverses age-associated decline in bone mass.
Osteosarcoma
alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression.
Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma.
Ovarian Neoplasms
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells.
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
Pancreatic Neoplasms
Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer.
Paralysis
Neuronal Ablation of Alpha/Beta Interferon (IFN-?/?) Signaling Exacerbates Central Nervous System Viral Dissemination and Impairs IFN-? Responsiveness in Microglia/Macrophages.
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
Paraplegia
Inactivation and subcellular redistribution of Ca2+/calmodulin-dependent protein kinase II following spinal cord ischemia.
Parathyroid Neoplasms
Calmodulin and calmodulin-dependent protein kinase II (CaMKII) inhibit hormone secretion in human parathyroid adenoma.
Parkinson Disease
A randomized controlled trial of levodopa in patients with Angelman syndrome.
Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies.
Improved detection of prostate cancer using a magneto-nanosensor assay for serum circulating autoantibodies.
Peritonitis
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.
Periventricular Nodular Heterotopia
AlphaCaMKII and NMDA-receptor subunit expression in epileptogenic cortex from human periventricular nodular heterotopia.
Pheochromocytoma
Activation of a calcium-calmodulin-dependent protein kinase I cascade in PC12 cells.
Ca2+-dependent phosphorylation of tyrosine hydroxylase in PC12 cells.
Hypoxia regulates the cAMP- and Ca2+/calmodulin signaling systems in PC12 cells.
Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells.
Phosphorylation of tyrosine hydroxylase on at least three sites in rat pheochromocytoma PC12 cells treated with 56 mM K+: determination of the sites on tyrosine hydroxylase phosphorylated by cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases.
Regulation of human tyrosine hydroxylase activity. Effects of cyclic AMP-dependent protein kinase, calmodulin-dependent protein kinase II and polyanion.
Retinoic acid stimulates alpha-CAMKII gene expression in PC12 cells at a distinct transcription initiation site.
Pick Disease of the Brain
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
Pituitary Neoplasms
Fibroblasts play a potential role in bone destruction via osteopontin related caldesmon expression and polymerization in human non-functioning pituitary adenomas.
Plant Diseases
Phylogeny of Plant Calcium and Calmodulin-Dependent Protein Kinases (CCaMKs) and Functional Analyses of Tomato CCaMK in Disease Resistance.
Polycystic Kidney, Autosomal Dominant
Gene profiling of polycystic kidneys.
Prader-Willi Syndrome
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Pre-Eclampsia
MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4.
Prediabetic State
Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca(2+) release events in a rodent model of early stage diabetes: The arrhythmogenic substrate.
Presbyopia
Enhancing trabecular outflow by disrupting the actin cytoskeleton, increasing uveoscleral outflow with prostaglandins, and understanding the pathophysiology of presbyopia interrogating Mother Nature: asking why, asking how, recognizing the signs, following the trail.
Primary Myelofibrosis
CAMK2G is identified as a novel therapeutic target for myelofibrosis.
Prostatic Neoplasms
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression.
Calcium/Calmodulin-Dependent Kinase II Plays an Important Role in Prostate Cancer Cell Survival.
Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells.
CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.
CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins.
CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties.
Down-regulation of calcium/calmodulin-dependent protein kinase kinase 2 by androgen deprivation induces castration-resistant prostate cancer.
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling.
Leupaxin stimulates adhesion and migration of prostate cancer cells through modulation of the phosphorylation status of the actin-binding protein caldesmon.
MicroRNA-224 and its target CAMKK2 synergistically influence tumor progression and patient prognosis in prostate cancer.
Nucleoporin 62 and Ca(2+) /calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells.
Organelle-derived acetyl-CoA promotes prostate cancer cell survival, migration, and metastasis via activation of calmodulin kinase II.
Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.
Targeting the 5'-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer.
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.
[A multi-omics study on NKX3.1-related node genes in prostate cancer].
Proteinuria
CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
Inhibition of calcium/calmodulin-dependent protein kinase type IV results in suppression of autoimmunity and organ pathology in lupus-prone mice.
Reperfusion Injury
Calcium-calmodulin-dependent protein kinase type 2 induces apoptosis of hepatocytes after liver transplantation.
Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy.
Role of calcium in inactivation of calcium/calmodulin dependent protein kinase II after cerebral ischemia.
Retinal Degeneration
A role for the light-dependent phosphorylation of visual arrestin.
Retinoblastoma
alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression.
KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway.
The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity.
Rhabdomyosarcoma
Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract.
Sarcoma
Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.
Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue.
h-Caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrial stromal sarcoma.
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases.
Sarcoma, Avian
A calmodulin-dependent protein kinase in Rous sarcoma virus-transformed rat cells and normal liver.
Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation.
Characterization of the properties of seven promoters in the motor cortex of rats and monkeys after lentiviral vector-mediated gene transfer.
Morphological and biochemical analyses of contractile proteins (actin, myosin, caldesmon and tropomyosin) in normal and transformed cells.
Sarcoma, Endometrial Stromal
h-Caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrial stromal sarcoma.
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Sarcoma, Synovial
Calponin and h-caldesmon expression in synovial sarcoma; the use of calponin in diagnosis.
Scrapie
Increased expression of CaM kinase II alpha in the brains of scrapie-infected mice.
The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models.
Seizures
Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.
Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat.
Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin.
Attenuation of the seizure-induced expression of BDNF mRNA in adult rat brain by an inhibitor of calcium/calmodulin-dependent protein kinases.
Bilirubin induces a calcium-dependent inhibition of multifunctional Ca2+/calmodulin-dependent kinase II activity in vitro.
Brief seizure activity alters Ca2+/calmodulin dependent protein kinase II dephosphorylation and subcellular distribution in rat brain for several hours.
Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy.
Decreased expression of the alpha subunit of Ca2+/ calmodulin-dependent protein kinase type II mRNA in the adult rat CNS following recurrent limbic seizures.
Dendritic targeting of mRNAs for plasticity genes in experimental models of temporal lobe epilepsy.
Entorhinal Principal Neurons Mediate Brain-stimulation Treatments for Epilepsy.
Increased levels of mRNA for beta- but not alpha-subunit of calmodulin kinase II following kindled seizures.
Leptin-regulated autophagy plays a role in long-term neurobehavioral injury after neonatal seizures and the regulation of zinc/cPLA2 and CaMK II signaling in cerebral cortex.
Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.
Loss of type II calcium/calmodulin-dependent kinase activity correlates with stages of development of electrographic seizures in status epilepticus in rat.
Mechanism of the inhibitory effect of histamine on amygdaloid-kindled seizures in rats.
miR-125a-5p alleviates dysfunction and inflammation of pentylenetetrazol-induced epilepsy through targeting calmodulin-dependent protein kinase IV (CAMK4).
Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity.
N-methyl-D-aspartate receptor dependent transcriptional regulation of two calcium/calmodulin-dependent protein kinase type II isoforms in rodent cerebral cortex.
Thymoquinone and Vitamin C Attenuates Pentylenetetrazole-Induced Seizures Via Activation of GABAB1 Receptor in Adult Rats Cortex and Hippocampus.
Zinc/CaMK II Associated-Mitophagy Signaling Contributed to Hippocampal Mossy Fiber Sprouting and Cognitive Deficits Following Neonatal Seizures and Its Regulation by Chronic Leptin Treatment.
ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats.
[Remote effects of early postnatal pituitary hormone melatonin injection on audiogenic seizures in Krushinsky-Molodkina rats]
Sepsis
Calcium Supplementation During Sepsis Exacerbates Organ Failure and Mortality via Calcium/Calmodulin-Dependent Protein Kinase Kinase Signaling.
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.
Calcium/calmodulin-dependent protein kinase (CaMK) I{alpha} mediates the macrophage inflammatory response to sepsis.
Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis.
CaMKIV regulates mitochondrial dynamics during sepsis.
Prevention of endotoxin-induced lethality in mice by calmodulin kinase activator.
Shock, Septic
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
Sick Sinus Syndrome
Insulin sensitization causes accelerated sinus nodal dysfunction through autophagic dysregulation in hypertensive mice.
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Situs Inversus
Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos.
Skin Diseases
Inhibition of calcium/calmodulin-dependent protein kinase type IV results in suppression of autoimmunity and organ pathology in lupus-prone mice.
Small Cell Lung Carcinoma
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) .
Smooth Muscle Tumor
h-Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors.
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer.
[Mesenchymal uterine tumors. Leiomyomas]
Spinal Cord Injuries
Activation of Ca2+/calmodulin-dependent protein kinase II alpha in the spinal cords of rats with clip compression injury.
Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury.
Phosphorylation of neuronal nitric oxide synthase at Ser847 in the nucleus intermediolateralis after spinal cord injury in mice.
Spinal Cord Ischemia
Effect of cerebral ischemia on calcium/calmodulin-dependent protein kinase II activity and phosphorylation.
Protein phosphorylation during ischemia.
Spinal cord ischemia reduces calcium/calmodulin-dependent protein kinase activity.
Squamous Cell Carcinoma of Head and Neck
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
ST Elevation Myocardial Infarction
Calcium/Calmodulin-Dependent Protein Kinase II Delta Inhibition and Ventricular Remodeling After Myocardial Infarction: A Randomized Clinical Trial.
Starvation
CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux.
Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling.
Status Epilepticus
Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat.
Decreased calmodulin kinase activity after status epilepticus.
Loss of type II calcium/calmodulin-dependent kinase activity correlates with stages of development of electrographic seizures in status epilepticus in rat.
Microglial calcium signaling is attuned to neuronal activity in awake mice.
Modulation of CaM kinase II activity is coincident with induction of status epilepticus in the rat pilocarpine model.
Status epilepticus results in an N-methyl-D-aspartate receptor-dependent inhibition of Ca2+/calmodulin-dependent kinase II activity in the rat.
Stomach Neoplasms
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
AMPK? phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation.
Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma.
Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein.
Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer.
Stroke
Bilirubin induces a calcium-dependent inhibition of multifunctional Ca2+/calmodulin-dependent kinase II activity in vitro.
Calcium/calmodulin-dependent protein kinase kinase ? is neuroprotective in stroke in aged mice.
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology.
Genetic deletion of calcium/calmodulin-dependent protein kinase kinase ? (CaMKK ?) or CaMK IV exacerbates stroke outcomes in ovariectomized (OVXed) female mice.
Global forebrain ischemia results in decreased immunoreactivity of calcium/calmodulin-dependent protein kinase II.
Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke.
Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke.
Obesity and ischemic stroke modulate the methylation levels of KCNQ1 in white blood cells.
Supranuclear Palsy, Progressive
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
Sweat Gland Neoplasms
CD34-positive stromal cells and alpha-smooth muscle actin-positive stromal cells in the tumor capsule of skin sweat gland neoplasms.
Syncope
Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor: A case report and review of the literature.
Synucleinopathies
Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein.
Tachycardia
The role of stretch, tachycardia and sodium-calcium exchanger in induction of early cardiac remodelling.
Tachycardia, Ventricular
Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Tauopathies
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
Tetanus
Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.
Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons.
[Role of phospho-calcium/ calmodulin-dependent protein kinase II in the induction and maintenance of long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn of the rat]
Thyroid Neoplasms
Calcium/Calmodulin-Dependent Protein Kinase II and Its Endogenous Inhibitor ? in Medullary Thyroid Cancer.
Tuberculosis
Mycobacterium tuberculosis phagosomes exhibit altered calmodulin-dependent signal transduction: contribution to inhibition of phagosome-lysosome fusion and intracellular survival in human macrophages.
The role of CAMKK2 polymorphisms in HIV-associated sensory neuropathy in South Africans.
Tuberous Sclerosis
AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor.
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Urinary Bladder Neck Obstruction
Effect of long-term partial bladder outlet obstruction on caldesmon isoforms and their correlation with contractile function.
Smooth muscle hypertrophy following partial bladder outlet obstruction is associated with overexpression of non-muscle caldesmon.
[Experimental study of the expression of the bladder wall proteins in bladder outlet obstruction in the rabbit]
Urinary Bladder Neoplasms
Overexpression of caldesmon is associated with tumor progression in patients with primary non-muscle-invasive bladder cancer.
Uterine Cervical Neoplasms
Systematic profiling of alternative splicing signature reveals prognostic predictor for cervical cancer.
Uterine Diseases
Caldesmon: new insights for diagnosing endometriosis.
Uterine Prolapse
Differential expression of smooth muscle regulatory proteins in the uterosacral ligaments of women with uterine prolapse.
Vascular Diseases
Caldesmon as a therapeutic target for proliferative vascular diseases.
Vascular System Injuries
CaMKII-delta isoform regulation of neointima formation after vascular injury.
Ventricular Dysfunction
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Ventricular Fibrillation
Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart.
Viremia
Polymorphisms in CAMKK2 associate with susceptibility to sensory neuropathy in HIV patients treated without stavudine.
Virus Diseases
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.
Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brain.
Whooping Cough
Agonist-specific alterations in receptor-phospholipase coupling following inactivation of Gi2alpha gene.
N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.
Wilms Tumor
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
miR-378c suppresses Wilms tumor development via negatively regulating CAMKK2.