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Information on EC 2.7.11.17 - Ca2+/calmodulin-dependent protein kinase and Organism(s) Rattus norvegicus and UniProt Accession P97756

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EC Tree
IUBMB Comments
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
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Rattus norvegicus
UNIPROT: P97756
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
caldesmon, cam kinase ii, camkiv, cam kinase, calcium/calmodulin-dependent protein kinase ii, calmodulin-dependent protein kinase, camkk2, calcium/calmodulin-dependent protein kinase, ca2+/calmodulin-dependent protein kinase, camk ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+/calmodulin-dependent protein kinase kinase
-
alpha-calcium/calmodulin-dependent protein kinase II
-
-
alpha-CaMK-II
-
-
alphaCa2+/CaM-dependent protein kinase II
-
alphaCaMKII
Ca2+/calmodulin-dependent membrane-associated kinase
-
-
Ca2+/calmodulin-dependent protein kinase
-
Ca2+/calmodulin-dependent protein kinase Igamma
-
Ca2+/calmodulin-dependent protein kinase II
-
-
Ca2+/calmodulin-dependent protein kinase IIalpha
-
Ca2+/calmodulin-dependent protein kinase type IG
-
Ca2+/calmodulin-stimulated protein kinase II
-
-
Ca2+/CaM kinase II gamma G2
-
Ca2+/CaM-dependent protein kinase IIalpha
-
CAKI
-
-
-
-
calcium /calmodulin-dependent protein kinase II
-
-
calcium- and calmodulin-dependent kinase Ialpha
-
-
calcium-calmodulin-dependent protein kinase II
-
calcium/calmodulin dependent protein kinase II
-
-
calcium/calmodulin-dependent protein kinase
-
-
calcium/calmodulin-dependent protein kinase I
-
-
calcium/calmodulin-dependent protein kinase II
calcium/calmodulin-dependent protein kinase IIalpha
-
calcium/calmodulin-dependent protein kinase type I
-
calcium/calmodulin-dependent protein kinase type II alpha chain
-
calcium/calmodulin-dependent protein kinase type II beta chain
-
calcium/calmodulin-dependent protein kinase type II delta chain
-
calcium/calmodulin-dependent protein kinase type II gamma chain
-
calcium/calmodulin-dependent protein kinase type IV catalytic chain
-
caldesmon
-
-
-
-
calmodulin kinase I
-
-
Calspermin
CaM kinase Gr
-
CaM kinase II
-
-
CaM kinase IIalpha
-
-
CAM kinase-GR
-
-
-
-
CaM-dependent protein kinase I
-
-
CaM-dependent protein kinase II
-
-
CaM-K Ialpha
-
-
CaM-K II
-
-
CaM-K IIalpha
-
-
CaM-kinase I
CaM-kinase II
-
-
CaM-kinase III
-
-
CaM-kinase IV
-
-
CaMKI
CaMKIalpha
CaMKIIa
isozyme
CaMKIIalpha
CaMKIIbeta
CaMKIIdelta
-
-
CaMKIIdelta2
isozyme
CaMKIIgamma
-
-
CaMKIIgamma G2
-
CMPK
-
-
-
-
kinase, caldesmon (phosphorylating)
-
-
-
-
kinase, microtubule-associated protein 2 (phosphorylating)
-
-
-
-
MAP kinase
-
-
-
-
MAP-2 kinase
-
-
-
-
MAP-2 protein serine kinase
-
-
-
-
microtubule associated protein kinase
-
-
-
-
microtubule-associated protein 2 kinase
-
-
-
-
peripheral plasma membrane protein CaMGUK
-
-
-
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
141467-21-2
-
93229-57-3
-
97350-82-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 40S-ribosomal protein S6
?
show the reaction diagram
-
rat brain
-
-
?
ATP + Akt
ADP + phosphorylated Akt
show the reaction diagram
-
substrate of CaM-KII, phosphorylation at Thr308
-
-
?
ATP + Bcl10
ADP + phosphorylated Bcl10
show the reaction diagram
-
phosphorylation by CaMKII at Ser138, recombinant FLAG-tagged Bcl10 substrate expressed in HEK-293T cells
-
-
?
ATP + beta-Pak-interacting exchange factor
ADP + phosphorylated beta-Pak-interacting exchange factor
show the reaction diagram
beta-Pak-interacting exchange factor is phosphorylated at Ser156
-
-
?
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
show the reaction diagram
-
i.e. CREB, phosphorylation by CaMK II at Ser133
-
-
?
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
show the reaction diagram
ATP + cAMP-responsive element-binding protein
ADP + phosphorylated cAMP-responsive element-binding protein
show the reaction diagram
ATP + casein
?
show the reaction diagram
-
rat brain
-
-
?
ATP + CREB
ADP + phosphorylated CREB
show the reaction diagram
-
i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133
-
-
?
ATP + dystrophin Dp71d
ADP + phosphorylated dystrophin Dp71d
show the reaction diagram
ATP + estrogen-receptor from calf uterus
?
show the reaction diagram
-
-
-
-
?
ATP + GABA A receptor
ADP + phosphorylated GABA A receptor
show the reaction diagram
-
-
-
-
?
ATP + GABA-modulin
?
show the reaction diagram
-
-
-
-
?
ATP + glycogen synthase
?
show the reaction diagram
-
rat brain
-
-
?
ATP + histone
?
show the reaction diagram
ATP + histone deacetylase 4
ADP + phosphorylated histone deacetylase 4
show the reaction diagram
-
the enzyme may facilitate transcription factor activities by the neutralization of histone deacetylase 4 by phosphorylation, which may contribute to the phenotypic plasticity of gastrointestinal smooth muscle cells
-
-
?
ATP + human cardiac sodium channel NaV1.5
ADP + phosphorylated human cardiac sodium channel NaV1.5
show the reaction diagram
ATP + I-kappaB
ADP + phosphorylated I-kappaB
show the reaction diagram
ATP + MAP2
ADP + phosphorylated MAP2
show the reaction diagram
-
-
-
-
?
ATP + microtubule affinity regulating kinase 2
ADP + phosphorylated microtubule affinity regulating kinase 2
show the reaction diagram
ATP + microtubule associated protein 2
ADP + phosphorylated microtubule associated protein 2
show the reaction diagram
-
-
-
-
?
ATP + microtubule-associated protein 2
ADP + microtubule-associated protein 2 phosphate
show the reaction diagram
ATP + microtubule-associated protein tau
?
show the reaction diagram
ATP + myelin basic protein
?
show the reaction diagram
ATP + myosin light chain
?
show the reaction diagram
ATP + neuronal nitric-oxide synthase
ADP + phosphorylated neuronal nitric-oxide synthase
show the reaction diagram
ATP + NHE-1
ADP + phosphorylated NHE-1
show the reaction diagram
ATP + PC12 pheochromacytoma cell line protein substrate pp250
?
show the reaction diagram
-
-
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
show the reaction diagram
ATP + PLN
ADP + phosphorylated PLN
show the reaction diagram
ATP + PLRRTLSVAA-amide
ADP + phosphorylated PLRRTLSVAA-amide
show the reaction diagram
-
glycogen synthase-derived peptide GSP
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein CREB
ADP + phosphorylated protein CREB
show the reaction diagram
ATP + protein kinase G
ADP + phosphorylated protein kinase G
show the reaction diagram
-
-
-
?
ATP + Raf-1 protein
ADP + phosphorylated Raf-1 protein
show the reaction diagram
ATP + ryanodine receptor type 2
ADP + phosphorylated ryanodine receptor type 2
show the reaction diagram
-
-
-
-
?
ATP + synapsin
?
show the reaction diagram
-
rat brain
-
-
?
ATP + synapsin
ADP + phosphorylated synapsin
show the reaction diagram
-
-
-
-
?
ATP + synapsin I
ADP + phosphorylated synapsin I
show the reaction diagram
-
substrate of CaM-KI
-
-
?
ATP + synapsin II
ADP + phosphorylated synapsin II
show the reaction diagram
-
substrate of CaM-KI
-
-
?
ATP + synGAP
ADP + phosphorylated synGAP
show the reaction diagram
ATP + syntide-2
ADP + phosphorylated syntide-2
show the reaction diagram
a peptide substrate
-
-
?
ATP + tau peptide 408-420
ADP + phosphorylated tau peptide 408-420
show the reaction diagram
-
recombinant substrate expressed in Escherichia coli, phosphorylation at Ser416 by CaM kinase II, no activity with the peptide by CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
ATP + tubulin
?
show the reaction diagram
ATP + vimentin
?
show the reaction diagram
-
rat brain
-
-
?
ATP + voltage-gated calcium channel beta1b subunit
ADP + phosphorylated voltage-gated calcium channel beta1b subunit
show the reaction diagram
-
-
-
?
ATP + voltage-gated calcium channel beta2a subunit
ADP + phosphorylated voltage-gated calcium channel beta2a subunit
show the reaction diagram
CaMKII phosphorylates at Thr498
-
-
?
ATP + voltage-gated calcium channel beta3 subunit
ADP + phosphorylated voltage-gated calcium channel beta3 subunit
show the reaction diagram
-
-
-
?
ATP + voltage-gated calcium channel beta4 subunit
ADP + phosphorylated voltage-gated calcium channel beta4 subunit
show the reaction diagram
-
-
-
?
ATP + YLRRRLSDSNF
ADP + ?
show the reaction diagram
synapsin site I-derived peptide substrate
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
show the reaction diagram
-
i.e. CREB, phosphorylation by CaMK II at Ser133
-
-
?
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
show the reaction diagram
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133
-
-
?
ATP + cAMP-responsive element-binding protein
ADP + phosphorylated cAMP-responsive element-binding protein
show the reaction diagram
-
i.e. CREB, CaM kinase II, as part of the Ca2+ and CaMK signaling cascade, regulates the phosphorylation of CREB of spinal cord in rats following noxious stimulation, e.g. by capsaicin injection
-
-
?
ATP + dystrophin Dp71d
ADP + phosphorylated dystrophin Dp71d
show the reaction diagram
-
the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization
-
-
?
ATP + histone deacetylase 4
ADP + phosphorylated histone deacetylase 4
show the reaction diagram
-
the enzyme may facilitate transcription factor activities by the neutralization of histone deacetylase 4 by phosphorylation, which may contribute to the phenotypic plasticity of gastrointestinal smooth muscle cells
-
-
?
ATP + human cardiac sodium channel NaV1.5
ADP + phosphorylated human cardiac sodium channel NaV1.5
show the reaction diagram
-
the intracellular loop between domains 1 and 2 of cardiac sodium channel NaV1.5 is phosphorylated specifically at the Ser516 and Thr594 sites. The phosphorylation status of Ser516 and Thr594 on cardiac sodium channel NaV1.5, is an important mediator of the enzyme-dependent negative shift in cardiac sodium channel NaV1.5
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
show the reaction diagram
-
substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB
-
-
?
ATP + MAP2
ADP + phosphorylated MAP2
show the reaction diagram
-
-
-
-
?
ATP + microtubule affinity regulating kinase 2
ADP + phosphorylated microtubule affinity regulating kinase 2
show the reaction diagram
-
CaMKIalpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth/axonal extension
-
-
?
ATP + neuronal nitric-oxide synthase
ADP + phosphorylated neuronal nitric-oxide synthase
show the reaction diagram
-
phosphorylation at Ser741 by CaM-K Ialpha, wild-type and truncation mutant 1-293 inhibits neuronal nitric-oxide synthase, nNOS, no substrate of CaM-K IIalpha and CaM-K IV
-
-
?
ATP + NHE-1
ADP + phosphorylated NHE-1
show the reaction diagram
-
phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
show the reaction diagram
-
phosphorylation by CaMKII activates the sarcoplasmic reticulum Ca2+-ATPase, increasing both the rate of Ca2+ clearance from the myoplasm and the frequency of localized Ca2+ release events from intracellular stores
-
-
?
ATP + PLN
ADP + phosphorylated PLN
show the reaction diagram
-
phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
show the reaction diagram
-
CaMKII regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity
-
-
?
ATP + Raf-1 protein
ADP + phosphorylated Raf-1 protein
show the reaction diagram
-
the enzyme phosphorylates Raf-1 at Ser338 and mediates Ras-stimulated Raf-1 activation
-
-
?
ATP + synapsin
ADP + phosphorylated synapsin
show the reaction diagram
-
-
-
-
?
ATP + synGAP
ADP + phosphorylated synGAP
show the reaction diagram
-
regulation and activation of the neuron-specific Ras GTPase-activating protein, synGAP, by phosphorylation through CaMKII in the postsynaptic density fraction of the forebrain, synGAP is part of the signaling complex attached to the cytoplasmic tail of the N-methyl-D-aspartate-type glutamate receptor, overview
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
-
phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
Ca2+/calmodulin-dependent
KCl
-
KCl-induced cell depolarization stimulates Dp71d phosphorylation
Mn2+
-
activation
Pb2+
-
CaMKII activity and expression are altered in the hippocampus of Pb2+-exposed rats, reaction velocity is reduced by 41% and substrate affinity is increased by 22%, the rats exhibit deficits in hippocampal log-term potentiation and spatial learning, the content of CaMKIIbeta, but not of CaMKIIalpha, in the cytosolic fraction is reduced
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Aminopurine
-
-
2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
autocamtide 2-related inhibitory peptide
-
-
Calmidazolium
-
calmodulin antagonist
CaMK-II-Ntide
-
specific CaMK-II inhibitory peptide
-
Chloroquine
-
-
K252a
-
inhibits CaM-KII
KN-62
KN-93
KN62
-
a CaMKII-specific inhibitor
myristoylated autocamtide-2-related inhibitory peptide
-
-
myristoylated Trp peptide
0.0135 mM prevents alphaCaMKII clustering
N-(6-aminohexyl)-1-naphthalenesulfonamide
-
i.e. W7, a calcium-calmodulin inhibitor
NO
a reduction of CaMKII activity by S-nitrosylation at Cys6 is observed, but only after prolonged exposure of over 5 min to NO donors
phosphatidic acid
-
at high concentrations, activates at low concentrations
phosphatidylinositol
-
strong
PMCA4b
-
wild-type PMCA4b inhibits CASK activity, while PMCA4b mutant D672E, containing a point mutation in the ATP binding site, shows only 10% of the wild-type inhibitory potency
-
Protein kinase inhibitor H7
-
weak
-
quercetin
-
at high concentrations
staurosporine
-
at high concentrations
trifluoperazine dimaleate
-
calmodulin antagonist
W-13
-
calmodulin antagonist
W-7
-
calmodulin antagonist
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-amino-6-mercaptopurine
-
stimulation
2-O-tetradecanoyl phorbol 13-acetate
-
the activating effect is blocked by EGTA
beta-calmodulin-dependent kinase kinase
-
-
Calmodulin
ionomycin
-
-
isobutylmethylxanthine
-
slight stimulation
N-Methyl-D-aspartate
-
activates the phosphorylation of synGAP at Ser765 and Ser1123 by CaMKII in cortical neurons
neurotrophins
-
have a regulatory role
-
phosphatidic acid
-
activating at low concentrations, inhibitory at high concentrations
phosphatidylethanolamine
-
activation
phosphatidylserine
-
activation, addition leads to 100% phosphorylation of tau2-protein
protamine
-
stimulation
Ras(V12)
-
activates the enzyme, which, in turn, phosphorylates Raf-1 at Ser338 and participates in extracellular signal-regulated kinase activation upon different stimuli
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.013 - 0.03
ATP
0.00074 - 0.00081
MAP2
-
0.0016
microtubule associated protein 2
-
epidermal growth factor activated cells
-
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.17
myelin basic protein
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.8 - 1
-
microtubule associated protein 2 as substrate
3
-
myelin basic protein as substrate
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.6
-
assay at
additional information
-
pI: 4.9
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
alpha and beta isozymes
Manually annotated by BRENDA team
-
isozyme CaMKIIdelta splicing variants deltaB and deltaC
Manually annotated by BRENDA team
-
CaMKII is induced by neural differentiation of the embryonic carcinoma cells
Manually annotated by BRENDA team
-
a pheochromocytoma cell line, NGF-induced
Manually annotated by BRENDA team
-
predominant expression of CaMKII isozymes gammaA, gammaC, delta1, and delta3 in dopaminergic neurons
Manually annotated by BRENDA team
-
i.e. VSM cell, aortic, primary, isozymes CaMKIIgammaB, CaMKIIgammaC, and CaMKIIdelta2, expression analysis, overview
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
perinuclear, a nonsynaptic site
Manually annotated by BRENDA team
-
isozymes CaMKII alpha and CaMKIIbeta, contents of isozymes in membrane and cytosol of Pb2+ treated and untreated rats, overview
Manually annotated by BRENDA team
-
particulate enzyme shows increased rate of inhibitory autophosphorylation during acute seizure in the brain induced by electroconvulsive treatment
-
Manually annotated by BRENDA team
-
endoplasmic reticulum
-
Manually annotated by BRENDA team
-
soluble enzyme shows decreased rate of inhibitory autophosphorylation during acute seizure in the brain induced by electroconvulsive treatment
-
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
CaMKIIalpha inhibition protects from NO-induced neuronal cell death. Isozyme mutation of either site, Cys280 or Cys289, abolishes autonomous Ca2+-independent activity of the isozyme
metabolism
both signaling by nitric oxide (NO) and by isozyme CaMKIIalpha are implicated in two opposing forms of synaptic plasticity underlying learning and memory, as well as in excitotoxic/ischemic neuronal cell death
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KKCC1_RAT
505
0
55908
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
68000
x * 68000
18735
x * 18735, calculation from nucleotide sequence
40000
-
rat, growth-factor activated fibroblasts, gel filtration, sucrose density gradient centrifugation
42000
x * 42000, calculation from nucleotide sequence
43000
50000
500000 - 560000
-
brain CaMKII, gel filtration
51000
-
x * 51000 + x * 60000, phosphorylated enzyme, SDS-PAGE
519000
-
rat lung, gel filtration, sucrose density gradient centrifugation
52000
-
x * 52000, isozyme CaMKIIdelta2, SDS-PAGE
53000
x * 43000, CaMKIgamma2, SDS-PAGE, x * 53000, CaMKIgamma1, SDS-PAGE
54000
-
10 * 54000, alpha isozyme, + 8 * 60000, beta isozyme, CaMKII, SDS-PAGE
580000
-
rat brain, gel filtration
59038
x * 59038, calculation from nucleotide sequence
60000
65000
x * 65000 + x * 67000
67000
x * 65000 + x * 67000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
alphabeta
dodecamer
CaMKII forms 12meric holoenzymes via C-terminal association domains, with the kinase domains radiating outward
multimer
octadecamer
-
10 * 54000, alpha isozyme, + 8 * 60000, beta isozyme, CaMKII, SDS-PAGE
oligomer
-
CaMKII is a multimeric holoenzyme composed of six to twelve subunits encoded by 4 separate genes
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
S-nitrosylation
NO induces S-nitrosylation at Cys280/289 which directly generates autonomous activity of CaMKIIalpha, but simultaneous nitrosylation at both sites is required. And a reduction of CaMKIIalpha activity by S-nitrosylation at Cys6 is also observed, but only after prolonged exposure of over 5 min to NO donors
additional information
alternative splicing of internal exons may lead to the formation of the two different proteins, CaM kinase Gr and calspermin
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of calcium/calmodulin-dependent protein kinase I in the autoinhibited form
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A302R
-
mutation impairs Ca2+/calmodulin-binding
I205K
-
site-directed mutagenesis, the mutant CaMKII does not undergo self-association in recombinant HEK-293 cells
K42M/T286D
-
inactive CaMKII mutant
K42R
-
mutation without enzymatic activity
K52E
-
site-directed mutagenesis, inactive mutant
K52E/I286E/H287D/Q288D/S289D/W303S/F307A
-
site-directed mutagenesis of CaMKIalpha isozyme, the mutant is inactive and unable to bind Ca2+ and calmodulin
T286A
T286D
T287D
constitutively active mutant
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
from forebrain by ammonium sulfate fractionation, and calmodulin and phosphate affinity chromatography
-
heart or spleen: partial
-
insulin stimulated 1HIRc B-cells
-
partial: growth-factor stimulated 3Y1-cells
-
recombinant GST-tagged CaMKI from Escherichia coli by glutathione affinity chromatography
-
Talon spin column chromatography and Superdex 75 gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in COS-7 cells
CaMKI isozyme expression analysis
-
CaMKIgamma1 and CaMKIgamma2, DNA and amino acid sequence, and genomic structure determination and analysis, expression of FLAG-tagged enzymes in COS_7 cells, hippocampal neurons, and NG108-15 cells in the cytoplasm and neurites, not in the nucleus
CaMKII isozymes and splicing variants, DNA and amino acid sequence determination and analysis, gene structure and genomic organization of isozyme beta
-
characterization of a cDNA clone
expressed in bacteria as a glutathione S-transferase fusion protein
expressed in COS-7 and CHO cells
expressed in HEK-293 cells
expression of CaMKIalpha in COS-7 cells with localization in the Golgi apparatus and the plasma membrane
-
expression of CaMKII N-terminal catalytic fragment comprising residues 1-290 in Jurkat cells
-
expression of GFP-tagged wild-type and mutant CaMKII in neuronal cultures and in HEK-293 cells, pH-dependent, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview
-
expression of GST-tagged CaMKI in Escherichia coli
-
expression of HA-tagged wild-type CaM-KIalpha, CaM-K IV, and CaM-K IIalpha, and CaM-K Ialpha mutant K49A, and constitutively active CaM-K Ialpha truncation mutant residues 1-293 in HEK293 cells, Escherichia coli, and Sf9 insect cells
-
isolation of cDNA
organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene
overexpression of CaMKII isozyme alpha and truncated mutant CaMKII/290 in PC-12 cells
-
recombinant expression of GST-tagged CaMKIIalpha in HEK-293 cells
recombinant expression of GST-tagged wild-type enzyme 1-293 and GST-tagged mutant K49E enzyme 1-293 in Escherichia coli strain JM109
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in genetic absence epilepsy rats from Strasbourg, enzyme levels are higher in the thalamus after the acute and chronic application of spike-and-wave discharges-suppressing doses of atipamezole (0.012 and 0.031 mg) compared to artificial cerebrospinal fluid
-
nitric oxide induces Ca2+-independent activity of Ca2+/calmodulin-dependent protein kinase II
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schulman, H.; Kuret, J.; Bennett Jefferson, A.; Nose, P.S.; Spitzer, K.H.
Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase: broad substrate specificity and multifunctional potential in diverse tissues
Biochemistry
24
5320-5327
1985
Aplysia californica, Rattus norvegicus
Manually annotated by BRENDA team
Schanen, N.C.; Landreth, G.
Isolation and characterization of microtubule-associated protein 2 (MAP2) kinase from rat brain
Mol. Brain Res.
14
43-50
1992
Rattus norvegicus
Manually annotated by BRENDA team
Baudier, J.; Cole, R.D.
Phosphorylation of tau proteins to a state like that in Alzheimers brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids
J. Biol. Chem.
262
17577-17583
1987
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Boulton, T.G.; Gregory, J.S.; Cobb, M.H.
Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase
Biochemistry
30
278-286
1991
Rattus norvegicus
Manually annotated by BRENDA team
Hoshi, M.; Nishida, E.; Sakai, H.
Characterization of a mitogen-activated, Ca2+-sensitive microtubule-associated protein-2 kinase
Eur. J. Biochem.
184
477-486
1989
Rattus norvegicus
Manually annotated by BRENDA team
Tokumitsu, H.; Enslen, H.; Soderling, T.R.
Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase
J. Biol. Chem.
270
19320-19324
1995
Rattus norvegicus (P97756)
Manually annotated by BRENDA team
Bennett, M.K.; Kennedy, M.B.
Deduced primary structure of the beta subunit of brain type II Ca2+/calmodulin-dependent protein kinase determined by molecular cloning
Proc. Natl. Acad. Sci. USA
84
1794-1798
1987
Rattus norvegicus (P08413)
Manually annotated by BRENDA team
Hanley, R.M.; Means, A.R.; Ono, T.; Kemp, B.E.; Burgin, K.E.; Waxham, N.; Kelly, P.T.
Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II
Science
237
293-297
1987
Rattus norvegicus (P11275)
Manually annotated by BRENDA team
Lin, C.R.; Kapiloff, M.S.; Durgerian, S.; Tatemoto, K.; Russo, A.F.; Hanson, P.; Schulman, H.; Rosenfeld, M.G.
Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase
Proc. Natl. Acad. Sci. USA
84
5962-5966
1987
Rattus norvegicus (P11275)
Manually annotated by BRENDA team
Sunyer, T.; Sahyoun, N.
Sequence analysis and DNA-protein interactions within the 5' flanking region of the Ca2+/calmodulin-dependent protein kinase II alpha-subunit gene
Proc. Natl. Acad. Sci. USA
87
278-282
1990
Rattus norvegicus (P11275)
Manually annotated by BRENDA team
Thiel, G.; Czernik, A.J.; Gorelick, F.; Nairn, A.C.; Greengard, P.
Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity
Proc. Natl. Acad. Sci. USA
85
6337-6341
1988
Rattus norvegicus (P11275)
Manually annotated by BRENDA team
Tobimatsu, T.; Kameshita, I.; Fujisawa, H.
Molecular cloning of the cDNA encoding the third polypeptide (gamma) of brain calmodulin-dependent protein kinase II
J. Biol. Chem.
263
16082-16086
1988
Rattus norvegicus (P11730)
Manually annotated by BRENDA team
Zhou, Z.L.; Ikebe, M.
New isoforms of Ca2+/calmodulin-dependent protein kinase II in smooth muscle
Biochem. J.
299
489-495
1994
Rattus norvegicus (P11730)
-
Manually annotated by BRENDA team
Means, A.R.; Cruzalegui, F.; LeMagueresse, B.; Needleman, D.S.; Slaughter, G.R.; Ono, T.
A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene
Mol. Cell. Biol.
11
3960-3971
1991
Rattus norvegicus (P13234)
Manually annotated by BRENDA team
Ohmstede, C.A.; Jensen, K.F.; Sahyoun, N.E.
Ca2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells. Identification of a novel neuronal calmodulin-dependent protein kinase
J. Biol. Chem.
264
5866-5875
1989
Rattus norvegicus (P13234)
Manually annotated by BRENDA team
Ohmstede, C.A.; Bland, M.M.; Merrill, B.M.; Sahyoun, N.
Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene
Proc. Natl. Acad. Sci. USA
88
5784-5788
1991
Rattus norvegicus (P13234)
Manually annotated by BRENDA team
Ono, T.; Slaughter, G.R.; Cook, R.G.; Means, A.R.
Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein
J. Biol. Chem.
264
2081-2087
1989
Rattus norvegicus (P13234)
Manually annotated by BRENDA team
Sun, Z.; Means, R.L.; LeMagueresse, B.; Means, A.R.
Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene
J. Biol. Chem.
270
29507-29514
1995
Rattus norvegicus (P13234)
Manually annotated by BRENDA team
Schworer, C.M.; Rothblum, L.I.; Thekkumkara, T.J.; Singer, H.A.
Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta
J. Biol. Chem.
268
14443-14449
1993
Rattus norvegicus (P15791)
Manually annotated by BRENDA team
Tobimatsu, T.; Fujisawa, H.
Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs
J. Biol. Chem.
264
17907-17912
1989
Rattus norvegicus (P15791)
Manually annotated by BRENDA team
Cho, F.S.; Phillips, K.S.; Bogucki, B.; Weaver, T.E.
Characterization of a rat cDNA clone encoding calcium/calmodulin-dependent protein kinase I
Biochim. Biophys. Acta
1224
156-160
1994
Rattus norvegicus (Q63450)
Manually annotated by BRENDA team
Goldberg, J.; Nairn, A.C.; Kuriyan, J.
Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I
Cell
84
875-887
1996
Rattus norvegicus (Q63450)
Manually annotated by BRENDA team
Picciotto, M.R.; Czernik, A.J.; Nairn, A.C.
Calcium/calmodulin-dependent protein kinase I. cDNA cloning and identification of autophosphorylation site
J. Biol. Chem.
268
26512-26521
1993
Rattus norvegicus (Q63450)
Manually annotated by BRENDA team
Yamauchi, T.
Neuronal Ca2+/calmodulin-dependent protein kinase II - discovery, progress in a quarter of a century, and perspective: implication for learning and memory
Biol. Pharm. Bull.
28
1342-1354
2005
Drosophila melanogaster, Rattus norvegicus
Manually annotated by BRENDA team
Toscano, C.D.; O'Callaghan, J.P.; Guilarte, T.R.
Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed rats
Brain Res.
1044
51-58
2005
Rattus norvegicus
Manually annotated by BRENDA team
Zhang, T.; Brown, J.H.
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure
Cardiovasc. Res.
63
476-486
2004
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Rodriguez-Mora, O.; LaHair, M.M.; Howe, C.J.; McCubrey, J.A.; Franklin, R.A.
Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy
Expert Opin. Ther. Targets
9
791-808
2005
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Song, T.; Hatano, N.; Horii, M.; Tokumitsu, H.; Yamaguchi, F.; Tokuda, M.; Watanabe, Y.
Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation
FEBS Lett.
570
133-137
2004
Rattus norvegicus
Manually annotated by BRENDA team
Takemoto-Kimura, S.; Terai, H.; Takamoto, M.; Ohmae, S.; Kikumura, S.; Segi, E.; Arakawa, Y.; Furuyashiki, T.; Narumiya, S.; Bito, H.
Molecular cloning and characterization of CLICK-III/CaMKIg, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK)
J. Biol. Chem.
278
18597-18605
2003
Rattus norvegicus, Mus musculus (Q91VB2), Homo sapiens (Q96NX5)
Manually annotated by BRENDA team
Schuh, K.; Uldrijan, S.; Gambaryan, S.; Roethlein, N.; Neyses, L.
Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK
J. Biol. Chem.
278
9778-9783
2003
Rattus norvegicus
Manually annotated by BRENDA team
Oh, J.S.; Manzerra, P.; Kennedy, M.B.
Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II
J. Biol. Chem.
279
17980-17988
2004
Rattus norvegicus
Manually annotated by BRENDA team
Robison, A.J.; Bass, M.A.; Jiao, Y.; MacMillan, L.B.; Carmody, L.C.; Bartlett, R.K.; Colbran, R.J.
Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2
J. Biol. Chem.
280
35329-35336
2005
Mus musculus, Rattus norvegicus, Sus scrofa, Xenopus laevis
Manually annotated by BRENDA team
Nishimura, H.; Sakagami, H.; Uezu, A.; Fukunaga, K.; Watanabe, M.; Kondo, H.
Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase Ig in the rat brain
J. Neurochem.
85
1216-1227
2003
Rattus norvegicus (Q7TNJ7)
Manually annotated by BRENDA team
Yamagata, Y.; Obata, K.
Ca2+/calmodulin-dependent protein kinase II is reversibly autophosphorylated, inactivated and made sedimentable by acute neuronal excitation in rats in vivo
J. Neurochem.
91
745-754
2004
Rattus norvegicus
Manually annotated by BRENDA team
Yamamoto, H.; Hiragami, Y.; Murayama, M.; Ishizuka, K.; Kawahara, M.; Takashima, A.
Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain
J. Neurochem.
94
1438-1447
2005
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kamata, A.; Takeuchi, Y.; Fukunaga, K.
Identification of the isoforms of Ca2+/calmodulin-dependent protein kinase II and expression of brain-derived neurotrophic factor mRNAs in the substantia nigra
J. Neurochem.
96
195-203
2006
Rattus norvegicus
Manually annotated by BRENDA team
Schmitt, J.M.; Guire, E.S.; Saneyoshi, T.; Soderling, T.R.
Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation
J. Neurosci.
25
1281-1290
2005
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Hudmon, A.; Lebel, E.; Roy, H.; Sik, A.; Schulman, H.; Waxham, M.N.; De Koninck, P.
A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association
J. Neurosci.
25
6971-6983
2005
Rattus norvegicus
Manually annotated by BRENDA team
Zhen, X.; Goswami, S.; Abdali, S.A.; Gil, M.; Bakshi, K.; Friedman, E.
Regulation of cyclin-dependent kinase 5 and calcium/calmodulin-dependent protein kinase II by phosphatidylinositol-linked dopamine receptor in rat brain
Mol. Pharmacol.
66
1500-1507
2004
Rattus norvegicus
Manually annotated by BRENDA team
Fang, L.; Wu, J.; Zhang, X.; Lin, Q.; Willis, W.D.
Calcium/calmodulin dependent protein kinase II regulates the phosphorylation of cyclic AMP-responsive element-binding protein of spinal cord in rats following noxious stimulation
Neurosci. Lett.
374
1-4
2005
Rattus norvegicus
Manually annotated by BRENDA team
Xu, G.Y.; Huang, L.Y.
Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors
Proc. Natl. Acad. Sci. USA
101
11868-11873
2004
Rattus norvegicus
Manually annotated by BRENDA team
House, S.J.; Ginnan, R.G.; Armstrong, S.E.; Singer, H.A.
Calcium/calmodulin-dependent protein kinase II-delta isoform regulation of vascular smooth muscle cell proliferation
Am. J. Physiol. Cell Physiol.
292
C2276-C2287
2007
Rattus norvegicus
Manually annotated by BRENDA team
Robison, A.J.; Winder, D.G.; Colbran, R.J.; Bartlett, R.K.
Oxidation of calmodulin alters activation and regulation of CaMKII
Biochem. Biophys. Res. Commun.
356
97-101
2007
Rattus norvegicus
Manually annotated by BRENDA team
Takeda, H.; Kitaoka, Y.; Hayashi, Y.; Kumai, T.; Munemasa, Y.; Fujino, H.; Kobayashi, S.; Ueno, S.
Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity
Brain Res.
1184
306-3015
2007
Rattus norvegicus
Manually annotated by BRENDA team
Mattiazzi, A.; Vittone, L.; Mundina-Weilenmann, C.
Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis
Cardiovasc. Res.
73
648-656
2007
Rattus norvegicus
Manually annotated by BRENDA team
Calderilla-Barbosa, L.; Ortega, A.; Cisneros, B.
Phosphorylation of dystrophin Dp71d by Ca2+/calmodulin-dependent protein kinase II modulates the Dp71d nuclear localization in PC12 cells
J. Neurochem.
98
713-722
2006
Rattus norvegicus
Manually annotated by BRENDA team
Uboha, N.V.; Flajolet, M.; Nairn, A.C.; Picciotto, M.R.
A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth
J. Neurosci.
27
4413-4423
2007
Rattus norvegicus
Manually annotated by BRENDA team
Ishiguro, K.; Ando, T.; Goto, H.; Xavier, R.
Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II
Mol. Immunol.
44
2095-2100
2007
Rattus norvegicus
Manually annotated by BRENDA team
Kamata, A.; Sakagami, H.; Tokumitsu, H.; Owada, Y.; Fukunaga, K.; Kondo, H.
Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth
Neurosci. Res.
57
86-97
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Slonimsky, J.D.; Mattaliano, M.D.; Moon, J.I.; Griffith, L.C.; Birren, S.J.
Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission
Proc. Natl. Acad. Sci. USA
103
2915-2919
2006
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Said, M.; Becerra, R.; Palomeque, J.; Rinaldi, G.; Kaetzel, M.A.; Diaz-Sylvester, P.L.; Copello, J.A.; Dedman, J.R.; Mundina-Weilenmann, C.; Vittone, L.; Mattiazzi, A.
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II
Am. J. Physiol. Heart Circ. Physiol.
295
H1669-H1683
2008
Rattus norvegicus
Manually annotated by BRENDA team
Chen, G.D.; Peng, M.L.; Wang, P.Y.; Lee, S.D.; Chang, H.M.; Pan, S.F.; Chen, M.J.; Tung, K.C.; Lai, C.Y.; Lin, T.B.
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R487-R493
2008
Rattus norvegicus (P11275)
Manually annotated by BRENDA team
Gangopadhyay, S.S.; Gallant, C.; Sundberg, E.J.; Lane, W.S.; Morgan, K.G.
Regulation of Ca2+/calmodulin kinase II by a small C-terminal domain phosphatase
Biochem. J.
412
507-516
2008
Rattus norvegicus (P11730)
Manually annotated by BRENDA team
Grueter, C.E.; Abiria, S.A.; Wu, Y.; Anderson, M.E.; Colbran, R.J.
Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits
Biochemistry
47
1760-1767
2008
Rattus norvegicus (P15791)
Manually annotated by BRENDA team
Wang, P.; Wang, W.P.; Sun-Zhang, W.P.; Wang, H.X.; Yan-Lou, H.X.; Fan, Y.H.
Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats
Brain Res.
1238
108-117
2008
Rattus norvegicus (P11275)
Manually annotated by BRENDA team
Yousif, M.H.; Akhtar, S.; Walther, T.; Benter, I.F.
Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension
Cell Biochem. Funct.
26
256-263
2008
Rattus norvegicus
Manually annotated by BRENDA team
Grant, P.A.; Best, S.L.; Sanmugalingam, N.; Alessio, R.; Jama, A.M.; Toeroek, K.
A two-state model for Ca2+/CaM-dependent protein kinase II (alphaCaMKII) in response to persistent Ca2+ stimulation in hippocampal neurons
Cell Calcium
44
465-478
2008
Rattus norvegicus (P11275)
Manually annotated by BRENDA team
Houston, C.M.; Hosie, A.M.; Smart, T.G.
Distinct regulation of beta2 and beta3 subunit-containing cerebellar synaptic GABAA receptors by calcium/calmodulin-dependent protein kinase II
J. Neurosci.
28
7574-7584
2008
Rattus norvegicus
Manually annotated by BRENDA team
Saneyoshi, T.; Wayman, G.; Fortin, D.; Davare, M.; Hoshi, N.; Nozaki, N.; Natsume, T.; Soderling, T.R.
Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex
Neuron
57
94-107
2008
Rattus norvegicus (Q63450)
Manually annotated by BRENDA team
Perrino, B.A.
Regulation of gastrointestinal motility by Ca2+/calmodulin-stimulated protein kinase II
Arch. Biochem. Biophys.
510
174-181
2011
Rattus norvegicus
Manually annotated by BRENDA team
Hoffman, L.; Farley, M.M.; Waxham, M.N.
Calcium-calmodulin-dependent protein kinase II isoforms differentially impact the dynamics and structure of the actin cytoskeleton
Biochemistry
52
1198-1207
2013
Rattus norvegicus (P08413), Rattus norvegicus (P11275), Homo sapiens (Q13555), Homo sapiens (Q13557)
Manually annotated by BRENDA team
Salzano, M.; Rusciano, M.R.; Russo, E.; Bifulco, M.; Postiglione, L.; Vitale, M.
Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation
Cell Cycle
11
2100-2106
2012
Rattus norvegicus
Manually annotated by BRENDA team
Ashpole, N.M.; Herren, A.W.; Ginsburg, K.S.; Brogan, J.D.; Johnson, D.E.; Cummins, T.R.; Bers, D.M.; Hudmon, A.
Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites
J. Biol. Chem.
287
19856-19869
2012
Rattus norvegicus
Manually annotated by BRENDA team
Coultrap, S.J.; Bayer, K.U.
Nitric oxide induces Ca2+-independent activity of the Ca2+/calmodulin-dependent protein kinase II (CaMKII)
J. Biol. Chem.
289
19458-19465
2014
Rattus norvegicus (P08413)
Manually annotated by BRENDA team
Fujiwara, Y.; Kawaguchi, Y.; Fujimoto, T.; Kanayama, N.; Magari, M.; Tokumitsu, H.
Differential AMP-activated protein kinase (AMPK) recognition mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms
J. Biol. Chem.
291
13802-13808
2016
Rattus norvegicus (Q63450)
Manually annotated by BRENDA team
Yavuz, M.; Ayd?n, B.; Carcak, N.; Akman, O.e.; Raci Yananli, H.; Onat, F.
Atipamezole, a specific alpha2A antagonist, suppresses spike-and-wave discharges and alters Ca2+ /calmodulin-dependent protein kinase II in the thalamus of genetic absence epilepsy rats
Epilepsia
61
2825-2835
2020
Rattus norvegicus
Manually annotated by BRENDA team