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ATP + connexin36 protein
ADP + phosphorylated connexin36 protein
in the outer and inner retina, isoform CaMKII-beta colocalizes with connexin36-containing gap junctions
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
substrate of CaM-KII, phosphorylation at Thr308
-
-
?
ATP + autocamtide-2
ADP + phosphorylated autocamtide-2
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142
-
-
?
ATP + connexin36 protein
ADP + phosphorylated connexin36 protein
in inner retina, isoform CaMKII-delta colocalizes with connexin36 protein
-
-
?
ATP + CREB
ADP + phosphorylated CREB
-
i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133
-
-
?
ATP + Emi2
ADP + phosphorylated Emi2
an APC/C repressor, inactivation
-
-
?
ATP + glycosylated phosducin-like protein
ADP + glycosylated phosducin-like phosphoprotein
-
-
-
-
?
ATP + group I metabotropic glutamate receptor
ADP + phosphorylated group I metabotropic glutamate receptor
-
CaMKIV contributes to the upregulation of fragile X mental retardation protein induced by stimulating group I metabotropic glutamate receptors
-
-
?
ATP + histone deacetylase 4
ADP + phosphorylated histone deacetylase 4
-
-
-
-
?
ATP + histone deacetylase 5
ADP + phosphorylated histone deacetylase 5
-
whereas histone deacetylase 5 alone is unresponsive to CaMKII, it becomes responsive to CaMKII in the presence of histone deacetylase 4
-
-
?
ATP + Homer3 protein
ADP + Homer3 phosphoprotein
-
Homer3 protein is phosphorylated at Ser120, Ser159, and Ser176 by CaMKII
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
ATP + Kir6.2 subunit of cardiac ATP-sensitive potassium channel
ADP + phosphorylated Kir6.2 subunit of cardiac ATP-sensitive potassium channel
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
ATP + MEF-2A
ADP + phosphorylated MEF-2A
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2C
ADP + phosphorylated MEF-2C
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2D
ADP + phosphorylated MEF-2D
-
phosphorylation by CaMKIV
-
-
?
ATP + Na+-channel
ADP + phosphorylated Na+-channel
ATP + NFkappaB
ADP + phosphorylated NFkappaB
-
the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536
-
-
?
ATP + NMDA receptor
ADP + phosphorylated NMDA receptor
-
-
-
-
?
ATP + Notch1 protein
ADP + phosphorylated Notch1 protein
ATP + peptide AC2
ADP + phosphorylated peptides AC2
-
Ca2+-independent autonomous activity after Thr286 autophosphorylation is65% of maximal stimulated activity
-
-
?
ATP + PLB
ADP + phosphorylated PLB
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + PLRRTLSVAA
ADP + ?
-
-
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
ATP + protein ERK
ADP + phosphorylated protein ERK
activation by phosphorylation
-
-
?
ATP + protein HDAC
ADP + phosphorylated protein HDAC
ATP + protein PLN
ADP + phosphorylated Pprotein LN
-
PLN regulation through phosphorylation by CaMKII at Thr17
-
-
?
ATP + protein PLN
ADP + phosphorylated protein PLN
-
a sarcoplasmic reticulum protein, phosphorylation by CaMKII at Thr17
-
-
?
ATP + RyR
ADP + phosphorylated RyR
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + synapsin I
ADP + phosphorylated synapsin I
-
substrate of CaM-KI
-
-
?
ATP + synapsin II
ADP + phosphorylated synapsin II
-
substrate of CaM-KI
-
-
?
ATP + syntide-2
ADP + phosphorylated syntide-2
a peptide containing the R-X-X-S/T consensus phosphorylation site 2 of glycogen synthase within the sequence
-
-
?
ATP + syntide2
ADP + phosphorylated syntide2
-
Ca2+-independent autonomous activity after Thr286 autophosphorylation is25% of maximal stimulated activity
-
-
?
additional information
?
-
ATP + autocamtide-2
ADP + phosphorylated autocamtide-2
-
substrate in activity assay
-
-
?
ATP + autocamtide-2
ADP + phosphorylated autocamtide-2
highly selective peptide substrate for calcium/calmodulin-dependent protein kinase II
-
-
?
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
-
-
-
-
?
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
-
CaMKIV activates CREB by phosphorylation and stimulates CREB-mediated transcription
-
-
?
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
-
i.e. CREB
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
-
substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
-
substrate of CaM-KII
-
-
?
ATP + Kir6.2 subunit of cardiac ATP-sensitive potassium channel
ADP + phosphorylated Kir6.2 subunit of cardiac ATP-sensitive potassium channel
-
-
-
-
?
ATP + Kir6.2 subunit of cardiac ATP-sensitive potassium channel
ADP + phosphorylated Kir6.2 subunit of cardiac ATP-sensitive potassium channel
-
phosphorylation of Kir6.2 subunit of cardiac ATP-sensitive potassium channel promotes endocytosis of cardiac ATP-sensitive potassium channels
-
-
?
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
-
inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias
-
-
?
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
-
inactivation by CaMKII
-
-
?
ATP + Na+-channel
ADP + phosphorylated Na+-channel
-
-
-
-
?
ATP + Na+-channel
ADP + phosphorylated Na+-channel
-
isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview
-
-
?
ATP + Notch1 protein
ADP + phosphorylated Notch1 protein
-
-
-
?
ATP + Notch1 protein
ADP + phosphorylated Notch1 protein
phosphorylation of Notch1 intracellular domain inhibits the proteasomal degradation of Notch1 intracellular domain through Fbw7 ubiquitin-protein ligase complex. Upregulated Notch1 intracellular domain accelerates osteoclast differentiation
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
activation by phosphorylation
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
-
the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536
-
-
?
ATP + protein HDAC
ADP + phosphorylated protein HDAC
-
phosphorylation by nuclear CaMKII results in HDAC translocation from nucleus to cytoplasm
-
-
?
ATP + protein HDAC
ADP + phosphorylated protein HDAC
-
nuclear CaMKII
-
-
?
additional information
?
-
-
the enzyme performs autophosphorylation
-
-
?
additional information
?
-
-
calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview
-
-
?
additional information
?
-
-
CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview
-
-
?
additional information
?
-
-
CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview
-
-
?
additional information
?
-
-
CaMKII is required for gene transcription induced in the hippocampus by contextual fear conditioning, alphaCaMKII autophosphorylation is required for memory consolidation-specific transcription and formation of long term potentiation and memory, molecular mechanism, overview
-
-
?
additional information
?
-
-
CaMKIV regulation, overview, CaMKIV functions as a potent stimulator of Ca2+-dependent gene expression
-
-
?
additional information
?
-
-
Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview
-
-
?
additional information
?
-
-
CaMKII is a multifunctional enzyme
-
-
?
additional information
?
-
-
CaMKII performs autophosphorylation
-
-
?
additional information
?
-
-
isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview
-
-
?
additional information
?
-
CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview
-
-
?
additional information
?
-
-
CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview
-
-
?
additional information
?
-
-
CaMKI isozymes play distinct roles in hippocampal dendritic growth and neuronal development, overview
-
-
?
additional information
?
-
-
CaMKII is critical in regulating myocyte function with regard to excitation-contraction-relaxation cycles and excitation-transcription coupling
-
-
?
additional information
?
-
-
CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview
-
-
?
additional information
?
-
-
modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview
-
-
?
additional information
?
-
-
the enzyme is involved in dendritogenesis in cortical neurons and is required for brain-derived neurotropic factor-stimulated dendritic growth, and regulation of dendritic morphogenesis via the lipid-raft-delineated CL3-STEF-RAc pathway contributing to the development of cortical dendrites, overview
-
-
?
additional information
?
-
-
CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview
-
-
?
additional information
?
-
-
generation of Ca2+-independent activity after Thr286 autophosphorylation is a vital step in regulating synaptic plasticity and learning and memory. The autonomy is substrate-dependent, and low autonomy (15-25%) is the general default
-
-
?
additional information
?
-
-
generation of Ca2+-independent autonomous activity by Thr286 autophosphorylation
-
-
?
additional information
?
-
in terms of substrate specificity, the consensus sequences for phosphorylation by CaMKI, CaMKII, and CaMKIV are quite similar, and hence these kinases sometimes phosphorylate the same substrates, for example cAMP-response element-binding protein. Expression of Camk2g and Camk2d, but not Camk1 or Camk4, in Camk2g-/- eggs leads to degradation of exogenously expressed EMI2
-
-
?
additional information
?
-
-
in terms of substrate specificity, the consensus sequences for phosphorylation by CaMKI, CaMKII, and CaMKIV are quite similar, and hence these kinases sometimes phosphorylate the same substrates, for example cAMP-response element-binding protein. Expression of Camk2g and Camk2d, but not Camk1 or Camk4, in Camk2g-/- eggs leads to degradation of exogenously expressed EMI2
-
-
?
additional information
?
-
CaMKIIgamma possesses an intrinsic autophosphorylating activity, which renders the enzyme insensitive to changes in intracellular Ca2+ level
-
-
?
additional information
?
-
-
CaMKIIgamma possesses an intrinsic autophosphorylating activity, which renders the enzyme insensitive to changes in intracellular Ca2+ level
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + connexin36 protein
ADP + phosphorylated connexin36 protein
in the outer and inner retina, isoform CaMKII-beta colocalizes with connexin36-containing gap junctions
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
-
CaMKIV activates CREB by phosphorylation and stimulates CREB-mediated transcription
-
-
?
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142
-
-
?
ATP + connexin36 protein
ADP + phosphorylated connexin36 protein
in inner retina, isoform CaMKII-delta colocalizes with connexin36 protein
-
-
?
ATP + Emi2
ADP + phosphorylated Emi2
an APC/C repressor, inactivation
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
-
substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB
-
-
?
ATP + Kir6.2 subunit of cardiac ATP-sensitive potassium channel
ADP + phosphorylated Kir6.2 subunit of cardiac ATP-sensitive potassium channel
-
phosphorylation of Kir6.2 subunit of cardiac ATP-sensitive potassium channel promotes endocytosis of cardiac ATP-sensitive potassium channels
-
-
?
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
-
inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias
-
-
?
ATP + MEF-2A
ADP + phosphorylated MEF-2A
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2C
ADP + phosphorylated MEF-2C
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2D
ADP + phosphorylated MEF-2D
-
phosphorylation by CaMKIV
-
-
?
ATP + Na+-channel
ADP + phosphorylated Na+-channel
-
isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview
-
-
?
ATP + NFkappaB
ADP + phosphorylated NFkappaB
-
the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536
-
-
?
ATP + Notch1 protein
ADP + phosphorylated Notch1 protein
phosphorylation of Notch1 intracellular domain inhibits the proteasomal degradation of Notch1 intracellular domain through Fbw7 ubiquitin-protein ligase complex. Upregulated Notch1 intracellular domain accelerates osteoclast differentiation
-
-
?
ATP + PLB
ADP + phosphorylated PLB
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
ATP + protein ERK
ADP + phosphorylated protein ERK
activation by phosphorylation
-
-
?
ATP + protein HDAC
ADP + phosphorylated protein HDAC
-
phosphorylation by nuclear CaMKII results in HDAC translocation from nucleus to cytoplasm
-
-
?
ATP + protein PLN
ADP + phosphorylated Pprotein LN
-
PLN regulation through phosphorylation by CaMKII at Thr17
-
-
?
ATP + RyR
ADP + phosphorylated RyR
-
a regulatory protein in Ca2+ signaling
-
-
?
additional information
?
-
ATP + protein CREB
ADP + phosphorylated protein CREB
activation by phosphorylation
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
-
the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536
-
-
?
additional information
?
-
-
calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview
-
-
?
additional information
?
-
-
CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview
-
-
?
additional information
?
-
-
CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview
-
-
?
additional information
?
-
-
CaMKII is required for gene transcription induced in the hippocampus by contextual fear conditioning, alphaCaMKII autophosphorylation is required for memory consolidation-specific transcription and formation of long term potentiation and memory, molecular mechanism, overview
-
-
?
additional information
?
-
-
CaMKIV regulation, overview, CaMKIV functions as a potent stimulator of Ca2+-dependent gene expression
-
-
?
additional information
?
-
-
Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview
-
-
?
additional information
?
-
CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview
-
-
?
additional information
?
-
-
CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview
-
-
?
additional information
?
-
-
CaMKI isozymes play distinct roles in hippocampal dendritic growth and neuronal development, overview
-
-
?
additional information
?
-
-
CaMKII is critical in regulating myocyte function with regard to excitation-contraction-relaxation cycles and excitation-transcription coupling
-
-
?
additional information
?
-
-
CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview
-
-
?
additional information
?
-
-
modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview
-
-
?
additional information
?
-
-
the enzyme is involved in dendritogenesis in cortical neurons and is required for brain-derived neurotropic factor-stimulated dendritic growth, and regulation of dendritic morphogenesis via the lipid-raft-delineated CL3-STEF-RAc pathway contributing to the development of cortical dendrites, overview
-
-
?
additional information
?
-
-
generation of Ca2+-independent activity after Thr286 autophosphorylation is a vital step in regulating synaptic plasticity and learning and memory. The autonomy is substrate-dependent, and low autonomy (15-25%) is the general default
-
-
?
additional information
?
-
in terms of substrate specificity, the consensus sequences for phosphorylation by CaMKI, CaMKII, and CaMKIV are quite similar, and hence these kinases sometimes phosphorylate the same substrates, for example cAMP-response element-binding protein. Expression of Camk2g and Camk2d, but not Camk1 or Camk4, in Camk2g-/- eggs leads to degradation of exogenously expressed EMI2
-
-
?
additional information
?
-
-
in terms of substrate specificity, the consensus sequences for phosphorylation by CaMKI, CaMKII, and CaMKIV are quite similar, and hence these kinases sometimes phosphorylate the same substrates, for example cAMP-response element-binding protein. Expression of Camk2g and Camk2d, but not Camk1 or Camk4, in Camk2g-/- eggs leads to degradation of exogenously expressed EMI2
-
-
?
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q13554), Homo sapiens (Q9UQM7), Metarhizium anisopliae (O14408), Mus musculus (Q923T9)
brenda
Jones, D.A.; Glod, J.; Wilson-Shaw, D.; Hahn, W.E.; Sikela, J.M.
cDNA sequence and differential expression of the mouse Ca2+/calmodulin-dependent protein kinase IV gene
FEBS Lett.
289
105-109
1991
Mus musculus (P08414), Mus musculus
brenda
Sikela, J.M.; Hahn, W.E.
Screening an expression library with a ligand probe: isolation and sequence of a cDNA corresponding to a brain calmodulin-binding protein
Proc. Natl. Acad. Sci. USA
84
3038-3042
1987
Mus musculus (P08414)
brenda
Sikela, J.M.; Law, M.L.; Kao, F.T.; Hartz, J.A.; Wei, Q.; Hahn, W.E.
Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV
Genomics
4
21-27
1989
Mus musculus (P08414), Mus musculus
brenda
Bayer, K.U.; Lohler, J.; Harbers, K.
An alternative, nonkinase product of the brain-specifically expressed Ca2+/calmodulin-dependent kinase II alpha isoform gene in skeletal muscle
Mol. Cell. Biol.
16
29-36
1996
Mus musculus (P11798)
brenda
Hanley, R.M.; Payne, M.E.; Cruzalegui, F.; Christenson, M.A.; Means, A.R.
Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain
Nucleic Acids Res.
17
3992
1989
Mus musculus (P11798)
brenda
Karls, U.; Muller, U.; Gilbert, D.J.; Copeland, N.G.; Jenkins, N.A.; Harbers, K.
Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant
Mol. Cell. Biol.
12
3644-3652
1992
Mus musculus (P28652), Mus musculus
brenda
Zhang, T.; Brown, J.H.
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure
Cardiovasc. Res.
63
476-486
2004
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Rodriguez-Mora, O.; LaHair, M.M.; Howe, C.J.; McCubrey, J.A.; Franklin, R.A.
Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy
Expert Opin. Ther. Targets
9
791-808
2005
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Takemoto-Kimura, S.; Terai, H.; Takamoto, M.; Ohmae, S.; Kikumura, S.; Segi, E.; Arakawa, Y.; Furuyashiki, T.; Narumiya, S.; Bito, H.
Molecular cloning and characterization of CLICK-III/CaMKIg, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK)
J. Biol. Chem.
278
18597-18605
2003
Rattus norvegicus, Mus musculus (Q91VB2), Homo sapiens (Q96NX5)
brenda
Anderson, K.A.; Noeldner, P.K.; Reece, K.; Wadzinski, B.E.; Means, A.R.
Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex
J. Biol. Chem.
279
31708-31716
2004
Mus musculus
brenda
Robison, A.J.; Bass, M.A.; Jiao, Y.; MacMillan, L.B.; Carmody, L.C.; Bartlett, R.K.; Colbran, R.J.
Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2
J. Biol. Chem.
280
35329-35336
2005
Mus musculus, Rattus norvegicus, Sus scrofa, Xenopus laevis
brenda
Schmitt, J.M.; Guire, E.S.; Saneyoshi, T.; Soderling, T.R.
Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation
J. Neurosci.
25
1281-1290
2005
Mus musculus, Rattus norvegicus
brenda
von Hertzen, L.S.; Giese, K.P.
alpha-Isoform of Ca2+/calmodulin-dependent kinase II autophosphorylation is required for memory consolidation-specific transcription
NeuroReport
16
1411-1414
2005
Mus musculus
brenda
Li, B.; Dedman, J.R.; Kaetzel, M.A.
Nuclear Ca2+/calmodulin-dependent protein kinase II in the murine heart
Biochim. Biophys. Acta
1763
1275-1281
2006
Mus musculus
brenda
Maier, L.S.; Bers, D.M.
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart
Cardiovasc. Res.
73
631-640
2007
Oryctolagus cuniculus, Homo sapiens, Mus musculus
brenda
Witczak, C.A.; Fujii, N.; Hirshman, M.F.; Goodyear, L.J.
Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation
Diabetes
56
1403-1409
2007
Mus musculus
brenda
Ang, E.S.; Zhang, P.; Steer, J.H.; Tan, J.W.; Yip, K.; Zheng, M.H.; Joyce, D.A.; Xu, J.
Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL)
J. Cell. Physiol.
212
787-795
2007
Mus musculus (Q923T9), Mus musculus, Mus musculus C57/Bl (Q923T9)
brenda
Wagner, S.; Dybkova, N.; Rasenack, E.C.; Jacobshagen, C.; Fabritz, L.; Kirchhof, P.; Maier, S.K.; Zhang, T.; Hasenfuss, G.; Brown, J.H.; Bers, D.M.; Maier, L.S.
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels
J. Clin. Invest.
116
3127-3138
2006
Mus musculus
brenda
Takemoto-Kimura, S.; Ageta-Ishihara, N.; Nonaka, M.; Adachi-Morishima, A.; Mano, T.; Okamura, M.; Fujii, H.; Fuse, T.; Hoshino, M.; Suzuki, S.; Kojima, M.; Mishina, M.; Okuno, H.; Bito, H.
Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma
Neuron
54
755-770
2007
Mus musculus
brenda
Kamata, A.; Sakagami, H.; Tokumitsu, H.; Sanda, M.; Owada, Y.; Fukunaga, K.; Kondo, H.
Distinct developmental expression of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases and their involvement in hippocampal dendritic formation
Neurosci. Lett.
423
143-148
2007
Mus musculus
brenda
Kamata, A.; Sakagami, H.; Tokumitsu, H.; Owada, Y.; Fukunaga, K.; Kondo, H.
Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth
Neurosci. Res.
57
86-97
2007
Mus musculus, Rattus norvegicus
brenda
Slonimsky, J.D.; Mattaliano, M.D.; Moon, J.I.; Griffith, L.C.; Birren, S.J.
Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission
Proc. Natl. Acad. Sci. USA
103
2915-2919
2006
Mus musculus, Rattus norvegicus
brenda
Gaines, P.; Lamoureux, J.; Marisetty, A.; Chi, J.; Berliner, N.
A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils
Exp. Hematol.
36
832-844
2008
Mus musculus (P08414), Mus musculus (Q6PGB8), Mus musculus
brenda
Wang, H.; Wu, L.J.; Zhang, F.; Zhuo, M.
Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors
J. Neurosci.
28
4385-4397
2008
Mus musculus
brenda
Mizutani, A.; Kuroda, Y.; Futatsugi, A.; Furuichi, T.; Mikoshiba, K.
Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells
J. Neurosci.
28
5369-5382
2008
Mus musculus
brenda
Lo Iacono, L.; Gross, C.
Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice
J. Neurosci.
28
6250-6257
2008
Mus musculus (P11798), Mus musculus
brenda
Backs, J.; Backs, T.; Bezprozvannaya, S.; McKinsey, T.A.; Olson, E.N.
Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4
Mol. Cell. Biol.
28
3437-3445
2008
Mus musculus
brenda
Sanchez-Blazquez, P.; Rodriguez-Munoz, M.; Montero, C.; de la Torre-Madrid, E.; Garzon, J.
Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein
Neuropharmacology
54
319-330
2008
Mus musculus
brenda
Skibinska-Kijek, A.; Radwanska, A.; Kossut, M.
Alpha calcium/calmodulin dependent protein kinase II in learning-dependent plasticity of mouse somatosensory cortex
Neuroscience
151
750-757
2008
Mus musculus
brenda
Zhang, G.R.; Cheng, X.R.; Zhou, W.X.; Zhang, Y.X.
Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of SAMP8 mice is modulated by anti-Alzheimers disease drugs
Neuroscience
159
308-315
2008
Mus musculus (P11798), Mus musculus
brenda
Luo, F.; Yang, C.; Chen, Y.; Shukla, P.; Tang, L.; Wang, L.X.; Wang, Z.J.
Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II
J. Pharmacol. Exp. Ther.
325
267-275
2008
Mus musculus
brenda
Chen, Y.; Luo, F.; Yang, C.; Kirkmire, C.M.; Wang, Z.J.
Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice
J. Pharmacol. Exp. Ther.
330
650-659
2009
Mus musculus
brenda
Matsumoto, S.; Murozono, M.; Nagaoka, D.; Matsuoka, S.; Takeda, A.; Narita, H.; Watanabe, S.; Isshiki, A.; Watanabe, Y.
Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains
Neurochem. Res.
33
2302-2309
2008
Mus musculus
brenda
Choi, Y.H.; Ann, E.J.; Yoon, J.H.; Mo, J.S.; Kim, M.Y.; Park, H.S.
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability
Biochim. Biophys. Acta
1833
69-79
2013
Mus musculus (P08414)
brenda
Hoffman, L.; Stein, R.A.; Colbran, R.J.; Mchaourab, H.S.
Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation
EMBO J.
30
1251-1262
2011
Caenorhabditis elegans (O62305), Mus musculus (P11798)
brenda
Coultrap, S.J.; Buard, I.; Kulbe, J.R.; DellAcqua, M.L.; Bayer, K.U.
CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin
J. Biol. Chem.
285
17930-17937
2010
Mus musculus
brenda
Li, W.; Li, H.; Sanders, P.N.; Mohler, P.J.; Backs, J.; Olson, E.N.; Anderson, M.E.; Grumbach, I.M.
The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21
J. Biol. Chem.
286
7990-7999
2011
Mus musculus (Q6PHZ2)
brenda
Sierra, A.; Zhu, Z.; Sapay, N.; Sharotri, V.; Kline, C.F.; Luczak, E.D.; Subbotina, E.; Sivaprasadarao, A.; Snyder, P.M.; Mohler, P.J.; Anderson, M.E.; Vivaudou, M.; Zingman, L.V.; Hodgson-Zingman, D.M.
Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II
J. Biol. Chem.
288
1568-1581
2013
Mus musculus
brenda
Medvedev, S.; Stein, P.; Schultz, R.M.
Specificity of calcium/calmodulin-dependent protein kinases in mouse egg activation
Cell Cycle
13
1482-1488
2014
Mus musculus (Q923T9), Mus musculus
brenda
Bele, T.; Fabbretti, E.
The scaffold protein calcium/calmodulin-dependent serine protein kinase controls ATP release in sensory ganglia upon P2X3 receptor activation and is part of an ATP keeper complex
J. Neurochem.
138
587-597
2016
Mus musculus, Mus musculus C57BL/6
brenda
Kool, M.; Van De Bree, J.; Bodde, H.; Elgersma, Y.; Van Woerden, G.
The molecular, temporal and region-specific requirements of the beta isoform of calcium/calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion
Sci. Rep.
6
26989
2016
Mus musculus (P28652), Mus musculus, Mus musculus C57BL/6 (P28652)
brenda
Tetenborg, S.; Yadav, S.C.; Hormuzdi, S.G.; Monyer, H.; Janssen-Bienhold, U.; Dedek, K.
Differential distribution of retinal Ca2+/calmodulin-dependent kinase II (CaMKII) isoforms indicates CaMKII-beta and -delta as specific elements of electrical synapses made of connexin36 (Cx36)
Front. Mol. Neurosci.
10
425
2017
Mus musculus (P28652), Mus musculus (Q6PHZ2)
brenda