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Information on EC 2.7.11.17 - Ca2+/calmodulin-dependent protein kinase and Organism(s) Mus musculus and UniProt Accession P08414

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IUBMB Comments
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
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This record set is specific for:
Mus musculus
UNIPROT: P08414
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
caldesmon, cam kinase ii, camkiv, cam kinase, calcium/calmodulin-dependent protein kinase ii, calmodulin-dependent protein kinase, camkk2, calcium/calmodulin-dependent protein kinase, ca2+/calmodulin-dependent protein kinase, camk ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
calcium/calmodulin-dependent protein kinase IV
-
calcium/calmodulin-dependent protein kinase type IV catalytic chain
-
CaMKIV
alpha-Ca2+/calmodulin-dependent protein kinase II
-
alphaCaMKII
Ca2+/calmodulin-dependent kinase II
-
-
Ca2+/calmodulin-dependent kinase IIdelta
-
Ca2+/calmodulin-dependent protein kinase
-
-
Ca2+/calmodulin-dependent protein kinase II
-
-
CAKI
-
-
-
-
calcium/calmodulin dependent protein kinase II
-
-
calcium/calmodulin dependent protein kinase II-alpha
-
-
calcium/calmodulin-dependent kinase
-
calcium/calmodulin-dependent protein kinase
calcium/calmodulin-dependent protein kinase 1G
-
calcium/calmodulin-dependent protein kinase II
-
-
calcium/calmodulin-dependent protein kinase II-alpha
-
calcium/calmodulin-dependent protein kinase IV
-
-
calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex
-
-
calcium/calmodulin-dependent protein kinase type 2
-
calcium/calmodulin-dependent protein kinase type II alpha chain
-
calcium/calmodulin-dependent protein kinase type II beta chain
-
calcium/calmodulin-dependent protein kinase type II gamma chain
-
calcium/calmodulin-dependent serine protein kinase
-
-
caldesmon
-
-
-
-
calmodulin kinase I
-
-
Calspermin
-
-
-
-
CaM kinase IG
-
CAM kinase-GR
-
-
-
-
CaM-K I
-
-
CaM-K II
-
-
CaM-K IV
-
-
CaM-kinase I
-
-
CaM-kinase II
-
-
CaM-kinase III
-
-
CaM-kinase IV
-
-
CaMK
-
-
CaMK-like CREB kinase-III
-
CaMKI
CaMKIgamma
-
CaMKII-alpha
-
-
CaMKII-beta
isoform
CaMKII-delta
isoform
CaMKIIalpha
CaMKIIdelta
-
CaMKIIgamma
-
CASK
-
-
CLICK-III
-
CLICK-III/CaMKIgamma
-
-
CMPK
-
-
-
-
kinase, caldesmon (phosphorylating)
-
-
-
-
kinase, microtubule-associated protein 2 (phosphorylating)
-
-
-
-
MAP kinase
-
-
-
-
MAP-2 kinase
-
-
-
-
MAP-2 protein serine kinase
-
-
-
-
microtubule associated protein kinase
-
-
-
-
microtubule-associated protein 2 kinase
-
-
-
-
peripheral plasma membrane protein CaMGUK
-
-
-
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
141467-21-2
-
93229-57-3
-
97350-82-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + Notch1 protein
ADP + phosphorylated Notch1 protein
show the reaction diagram
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + Akt
ADP + phosphorylated Akt
show the reaction diagram
-
substrate of CaM-KII, phosphorylation at Thr308
-
-
?
ATP + autocamtide-2
ADP + phosphorylated autocamtide-2
show the reaction diagram
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
show the reaction diagram
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
show the reaction diagram
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142
-
-
?
ATP + connexin36 protein
ADP + phosphorylated connexin36 protein
show the reaction diagram
ATP + CREB
ADP + phosphorylated CREB
show the reaction diagram
-
i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133
-
-
?
ATP + Emi2
ADP + phosphorylated Emi2
show the reaction diagram
an APC/C repressor, inactivation
-
-
?
ATP + glycosylated phosducin-like protein
ADP + glycosylated phosducin-like phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + group I metabotropic glutamate receptor
ADP + phosphorylated group I metabotropic glutamate receptor
show the reaction diagram
-
CaMKIV contributes to the upregulation of fragile X mental retardation protein induced by stimulating group I metabotropic glutamate receptors
-
-
?
ATP + histone deacetylase 4
ADP + phosphorylated histone deacetylase 4
show the reaction diagram
-
-
-
-
?
ATP + histone deacetylase 5
ADP + phosphorylated histone deacetylase 5
show the reaction diagram
-
whereas histone deacetylase 5 alone is unresponsive to CaMKII, it becomes responsive to CaMKII in the presence of histone deacetylase 4
-
-
?
ATP + Homer3 protein
ADP + Homer3 phosphoprotein
show the reaction diagram
-
Homer3 protein is phosphorylated at Ser120, Ser159, and Ser176 by CaMKII
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
show the reaction diagram
ATP + Kir6.2 subunit of cardiac ATP-sensitive potassium channel
ADP + phosphorylated Kir6.2 subunit of cardiac ATP-sensitive potassium channel
show the reaction diagram
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
show the reaction diagram
ATP + MEF-2A
ADP + phosphorylated MEF-2A
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2C
ADP + phosphorylated MEF-2C
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2D
ADP + phosphorylated MEF-2D
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + Na+-channel
ADP + phosphorylated Na+-channel
show the reaction diagram
ATP + NFkappaB
ADP + phosphorylated NFkappaB
show the reaction diagram
-
the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536
-
-
?
ATP + NMDA receptor
ADP + phosphorylated NMDA receptor
show the reaction diagram
-
-
-
-
?
ATP + peptide AC2
ADP + phosphorylated peptides AC2
show the reaction diagram
-
Ca2+-independent autonomous activity after Thr286 autophosphorylation is65% of maximal stimulated activity
-
-
?
ATP + PLB
ADP + phosphorylated PLB
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + PLRRTLSVAA
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
show the reaction diagram
ATP + protein ERK
ADP + phosphorylated protein ERK
show the reaction diagram
activation by phosphorylation
-
-
?
ATP + protein HDAC
ADP + phosphorylated protein HDAC
show the reaction diagram
ATP + protein PLN
ADP + phosphorylated Pprotein LN
show the reaction diagram
-
PLN regulation through phosphorylation by CaMKII at Thr17
-
-
?
ATP + protein PLN
ADP + phosphorylated protein PLN
show the reaction diagram
-
a sarcoplasmic reticulum protein, phosphorylation by CaMKII at Thr17
-
-
?
ATP + RyR
ADP + phosphorylated RyR
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + synapsin I
ADP + phosphorylated synapsin I
show the reaction diagram
-
substrate of CaM-KI
-
-
?
ATP + synapsin II
ADP + phosphorylated synapsin II
show the reaction diagram
-
substrate of CaM-KI
-
-
?
ATP + syntide-2
ADP + phosphorylated syntide-2
show the reaction diagram
a peptide containing the R-X-X-S/T consensus phosphorylation site 2 of glycogen synthase within the sequence
-
-
?
ATP + syntide2
ADP + phosphorylated syntide2
show the reaction diagram
-
Ca2+-independent autonomous activity after Thr286 autophosphorylation is25% of maximal stimulated activity
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + Notch1 protein
ADP + phosphorylated Notch1 protein
show the reaction diagram
phosphorylation of Notch1 intracellular domain inhibits the proteasomal degradation of Notch1 intracellular domain through Fbw7 ubiquitin-protein ligase complex. Upregulated Notch1 intracellular domain accelerates osteoclast differentiation
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
show the reaction diagram
-
CaMKIV activates CREB by phosphorylation and stimulates CREB-mediated transcription
-
-
?
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
show the reaction diagram
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142
-
-
?
ATP + connexin36 protein
ADP + phosphorylated connexin36 protein
show the reaction diagram
ATP + Emi2
ADP + phosphorylated Emi2
show the reaction diagram
an APC/C repressor, inactivation
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
show the reaction diagram
-
substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB
-
-
?
ATP + Kir6.2 subunit of cardiac ATP-sensitive potassium channel
ADP + phosphorylated Kir6.2 subunit of cardiac ATP-sensitive potassium channel
show the reaction diagram
-
phosphorylation of Kir6.2 subunit of cardiac ATP-sensitive potassium channel promotes endocytosis of cardiac ATP-sensitive potassium channels
-
-
?
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
show the reaction diagram
-
inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias
-
-
?
ATP + MEF-2A
ADP + phosphorylated MEF-2A
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2C
ADP + phosphorylated MEF-2C
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + MEF-2D
ADP + phosphorylated MEF-2D
show the reaction diagram
-
phosphorylation by CaMKIV
-
-
?
ATP + Na+-channel
ADP + phosphorylated Na+-channel
show the reaction diagram
-
isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview
-
-
?
ATP + NFkappaB
ADP + phosphorylated NFkappaB
show the reaction diagram
-
the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536
-
-
?
ATP + PLB
ADP + phosphorylated PLB
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
show the reaction diagram
ATP + protein ERK
ADP + phosphorylated protein ERK
show the reaction diagram
activation by phosphorylation
-
-
?
ATP + protein HDAC
ADP + phosphorylated protein HDAC
show the reaction diagram
-
phosphorylation by nuclear CaMKII results in HDAC translocation from nucleus to cytoplasm
-
-
?
ATP + protein PLN
ADP + phosphorylated Pprotein LN
show the reaction diagram
-
PLN regulation through phosphorylation by CaMKII at Thr17
-
-
?
ATP + RyR
ADP + phosphorylated RyR
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
dependent on
3-phosphoinositide
enzyme is dependent on
Calmodulin
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KN-93
interferes with Ca2+/calmodulin binding
2-[N-(2-hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
-
KN93
AC3-I peptide
-
i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII
AIP peptide
Calmidazolium
-
calmodulin antagonist
huperzine A
downregulates abnormally high expression of CaMKIIalpha
K252a
-
inhibits CaM-KII
KN-62
-
-
KN-93
peptide AIP
-
i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a reversible CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL
Trifluoperazine
-
-
trifluoperazine dimaleate
-
calmodulin antagonist
W-13
-
calmodulin antagonist
W-7
-
calmodulin antagonist
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
ionomycin
-
-
neurotrophins
-
have a regulatory role
-
receptor activator of nuclear factor kappa B ligand
-
-
additional information
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
assay at
7.4
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
receptor activator of nuclear factor kappa B ligand-differentiated, expression of CaMKI and CaMKIIgamma
Manually annotated by BRENDA team
isoform CaMKII-beta is abundant in OFF bipolar cells, which form electrical synapses in the outer and the inner retina
Manually annotated by BRENDA team
-
neonatal and posterior ventricular cardiac myocytes
Manually annotated by BRENDA team
Camk-2-specific transcripts are first seen in the head section of 12.5-day-old embryos
Manually annotated by BRENDA team
-
CaM-KI
Manually annotated by BRENDA team
-
trigeminal ganglia
Manually annotated by BRENDA team
-
CaM-KIV
Manually annotated by BRENDA team
skeletal muscle
Manually annotated by BRENDA team
-
isozyme CaMKIIdelta splicing variants deltaB and deltaC
Manually annotated by BRENDA team
-
isozymes CaMKIdelta and CaMKIalpha
Manually annotated by BRENDA team
CaMKIIgamma is the predominant CaMKII isoform in mouse eggs
Manually annotated by BRENDA team
receptor activator of nuclear factor kappa B ligand-differentiated, expression of CaMKI, CaMKIIgamma and also of CaMKIV at minimum level
Manually annotated by BRENDA team
-
expression of CaMKI isozymes alpha, beta, and delta, not of CaMKIV
Manually annotated by BRENDA team
-
isozyme CaMKIgamma
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
-
CaMKII isozymes have distinct cellular localizations and function
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
calcium/calmodulin-dependent protein kinase IV enhances osteoclast differentiation via the up-regulation of Notch1 protein stability
malfunction
metabolism
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KCC4_MOUSE
469
0
52628
Swiss-Prot
other Location (Reliability: 2)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
CaMKIV and CaMKI
multimer
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lipoprotein
-
the enzyme is modified in two sequential lipidification steps, CAAX prenylation followed by kinase-activity-regulated palmitoylation at C417, C419, C420, and C423, the modifications are essential for CL3 membrane anchoring and targeting of the enzyme into detergent-resistant lipid microdomains or rafts in dendrites, overview
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A303R
site-directed mutagenesis, the mutation interferes with calcium/calmodulin binding and activation of CAMK2B, as well as the autonomous (calcium/calmodulin-independent) activity of CAMK2B, and renders CAMK2B into a persistently F-actin bound state
C417S/C419S/C420S/C423S
-
site-directed mutagenesis, mutation of palmitoylation sites
K42M/T286D
-
inactive CaMKII mutant
K43M
site-directed mutagenesis, catalytically inactive form of CaMKIIgamma
K52A
-
site-directed mutagenesis, inactive mutant, loss-of-function in embryonic cortical neurons elicits a specific impairment in dendrite morphogenesis
T200A
-
site-directed mutagenesis, phosphorylation site mutant of CaMKIV, no activation by phosphorylation through CaMKK, no stimulation by ionomycin in absence of Ca2+ and calmodulin
T286A
mutant shows 50% reduction in phosphorylation activity
T286D
-
constitutively active CaMKII mutant
T287A
site-directed mutagenesis, an autophosphorylation-deficient CAMK2B mouse mutant. Nearly complete absence of T287-phosphorylated CAMK2B in Camk2bT287A/T287A mice without changes in T286-phosphorylated CAMK2A or total levels of both CAMK2A and CAMK2B
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant FLAG-tagged CaMKIV from 293A cells by immunoaffinity chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in COS-1 cells
gene is most likely located within the region of bands q21 to q23 of chromosome 5
CaMKI isozyme expression analysis
-
CaMKIgamma, DNA and amino acid sequence determination and analysis, expression as GFT-tagged protein in COS-7 cells with localization in the Golgi apparatus and the plasma membrane
determination of the complete cDNA sequence of the Camk-2 gene and most of its exon/intron structure, Camk-2 locus is mapped to the proximal region of mouse chromosome 11
expressed in COS-1 cells
expression in COS cells
-
expression in Sf9 cells
expression of FLAG-tagged CaMKIV in 293A cells
-
expression of wild-type and mutant CaMKI and CaMKIV in cultured neurons
-
expression of wild-type and mutant CL3 in COS-7 cells, expression of HA- or GFP-tagged wild-type CL3 in cortical neurons
-
gene Camk2g, recombinant expression in isozyme CaMKIIgamma-deficient mouse eggs and complementation by 80%, quantitative real-time RT-PCR expression analysis
overexpression of isozyme CaMKIIdeltaC in transgenic mouse myocytes or in rabbit myocytes using adenoviral transfection, affects on Ca2+ influx, Ca2+ current, and inhibition of Ca2+ channel inhibition through phosphorylation, overview
-
sequence of the cDNA for the alpha subunit
transient and stable overexpression of isozyme CaMKIIdelta in rabbit and mouse ventricular myocytes leading to a Ca2+-depdnent shift in voltage dependence of Na+ channel availability, enhanced intermediate inactivation, and slowed recovery from inactivation
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after vascular injury the enzyme is strongly expressed in neointima and media
intraplantarly injected complete Freund's adjuvant, CFA, is found to induce spinal activity of CaMKII, blocked by KN93
-
spinal nerve L5/L6 ligation, SNL, is found to increase the spinal activity of CaMKII on the ipsilateral side, blocked by KN93
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
blocking CaMKII or CaMKII-mediated signaling may offer a novel therapeutic target for the treatment of neuropathic pain
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q13554), Homo sapiens (Q9UQM7), Metarhizium anisopliae (O14408), Mus musculus (Q923T9)
Manually annotated by BRENDA team
Jones, D.A.; Glod, J.; Wilson-Shaw, D.; Hahn, W.E.; Sikela, J.M.
cDNA sequence and differential expression of the mouse Ca2+/calmodulin-dependent protein kinase IV gene
FEBS Lett.
289
105-109
1991
Mus musculus (P08414), Mus musculus
Manually annotated by BRENDA team
Sikela, J.M.; Hahn, W.E.
Screening an expression library with a ligand probe: isolation and sequence of a cDNA corresponding to a brain calmodulin-binding protein
Proc. Natl. Acad. Sci. USA
84
3038-3042
1987
Mus musculus (P08414)
Manually annotated by BRENDA team
Sikela, J.M.; Law, M.L.; Kao, F.T.; Hartz, J.A.; Wei, Q.; Hahn, W.E.
Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV
Genomics
4
21-27
1989
Mus musculus (P08414), Mus musculus
Manually annotated by BRENDA team
Bayer, K.U.; Lohler, J.; Harbers, K.
An alternative, nonkinase product of the brain-specifically expressed Ca2+/calmodulin-dependent kinase II alpha isoform gene in skeletal muscle
Mol. Cell. Biol.
16
29-36
1996
Mus musculus (P11798)
Manually annotated by BRENDA team
Hanley, R.M.; Payne, M.E.; Cruzalegui, F.; Christenson, M.A.; Means, A.R.
Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain
Nucleic Acids Res.
17
3992
1989
Mus musculus (P11798)
Manually annotated by BRENDA team
Karls, U.; Muller, U.; Gilbert, D.J.; Copeland, N.G.; Jenkins, N.A.; Harbers, K.
Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant
Mol. Cell. Biol.
12
3644-3652
1992
Mus musculus (P28652), Mus musculus
Manually annotated by BRENDA team
Zhang, T.; Brown, J.H.
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure
Cardiovasc. Res.
63
476-486
2004
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Rodriguez-Mora, O.; LaHair, M.M.; Howe, C.J.; McCubrey, J.A.; Franklin, R.A.
Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy
Expert Opin. Ther. Targets
9
791-808
2005
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Takemoto-Kimura, S.; Terai, H.; Takamoto, M.; Ohmae, S.; Kikumura, S.; Segi, E.; Arakawa, Y.; Furuyashiki, T.; Narumiya, S.; Bito, H.
Molecular cloning and characterization of CLICK-III/CaMKIg, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK)
J. Biol. Chem.
278
18597-18605
2003
Rattus norvegicus, Mus musculus (Q91VB2), Homo sapiens (Q96NX5)
Manually annotated by BRENDA team
Anderson, K.A.; Noeldner, P.K.; Reece, K.; Wadzinski, B.E.; Means, A.R.
Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex
J. Biol. Chem.
279
31708-31716
2004
Mus musculus
Manually annotated by BRENDA team
Robison, A.J.; Bass, M.A.; Jiao, Y.; MacMillan, L.B.; Carmody, L.C.; Bartlett, R.K.; Colbran, R.J.
Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2
J. Biol. Chem.
280
35329-35336
2005
Mus musculus, Rattus norvegicus, Sus scrofa, Xenopus laevis
Manually annotated by BRENDA team
Schmitt, J.M.; Guire, E.S.; Saneyoshi, T.; Soderling, T.R.
Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation
J. Neurosci.
25
1281-1290
2005
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
von Hertzen, L.S.; Giese, K.P.
alpha-Isoform of Ca2+/calmodulin-dependent kinase II autophosphorylation is required for memory consolidation-specific transcription
NeuroReport
16
1411-1414
2005
Mus musculus
Manually annotated by BRENDA team
Li, B.; Dedman, J.R.; Kaetzel, M.A.
Nuclear Ca2+/calmodulin-dependent protein kinase II in the murine heart
Biochim. Biophys. Acta
1763
1275-1281
2006
Mus musculus
Manually annotated by BRENDA team
Maier, L.S.; Bers, D.M.
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart
Cardiovasc. Res.
73
631-640
2007
Oryctolagus cuniculus, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Witczak, C.A.; Fujii, N.; Hirshman, M.F.; Goodyear, L.J.
Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation
Diabetes
56
1403-1409
2007
Mus musculus
Manually annotated by BRENDA team
Ang, E.S.; Zhang, P.; Steer, J.H.; Tan, J.W.; Yip, K.; Zheng, M.H.; Joyce, D.A.; Xu, J.
Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL)
J. Cell. Physiol.
212
787-795
2007
Mus musculus (Q923T9), Mus musculus, Mus musculus C57/Bl (Q923T9)
Manually annotated by BRENDA team
Wagner, S.; Dybkova, N.; Rasenack, E.C.; Jacobshagen, C.; Fabritz, L.; Kirchhof, P.; Maier, S.K.; Zhang, T.; Hasenfuss, G.; Brown, J.H.; Bers, D.M.; Maier, L.S.
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels
J. Clin. Invest.
116
3127-3138
2006
Mus musculus
Manually annotated by BRENDA team
Takemoto-Kimura, S.; Ageta-Ishihara, N.; Nonaka, M.; Adachi-Morishima, A.; Mano, T.; Okamura, M.; Fujii, H.; Fuse, T.; Hoshino, M.; Suzuki, S.; Kojima, M.; Mishina, M.; Okuno, H.; Bito, H.
Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma
Neuron
54
755-770
2007
Mus musculus
Manually annotated by BRENDA team
Kamata, A.; Sakagami, H.; Tokumitsu, H.; Sanda, M.; Owada, Y.; Fukunaga, K.; Kondo, H.
Distinct developmental expression of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases and their involvement in hippocampal dendritic formation
Neurosci. Lett.
423
143-148
2007
Mus musculus
Manually annotated by BRENDA team
Kamata, A.; Sakagami, H.; Tokumitsu, H.; Owada, Y.; Fukunaga, K.; Kondo, H.
Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth
Neurosci. Res.
57
86-97
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Slonimsky, J.D.; Mattaliano, M.D.; Moon, J.I.; Griffith, L.C.; Birren, S.J.
Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission
Proc. Natl. Acad. Sci. USA
103
2915-2919
2006
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Gaines, P.; Lamoureux, J.; Marisetty, A.; Chi, J.; Berliner, N.
A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils
Exp. Hematol.
36
832-844
2008
Mus musculus (P08414), Mus musculus (Q6PGB8), Mus musculus
Manually annotated by BRENDA team
Wang, H.; Wu, L.J.; Zhang, F.; Zhuo, M.
Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors
J. Neurosci.
28
4385-4397
2008
Mus musculus
Manually annotated by BRENDA team
Mizutani, A.; Kuroda, Y.; Futatsugi, A.; Furuichi, T.; Mikoshiba, K.
Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells
J. Neurosci.
28
5369-5382
2008
Mus musculus
Manually annotated by BRENDA team
Lo Iacono, L.; Gross, C.
Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice
J. Neurosci.
28
6250-6257
2008
Mus musculus (P11798), Mus musculus
Manually annotated by BRENDA team
Backs, J.; Backs, T.; Bezprozvannaya, S.; McKinsey, T.A.; Olson, E.N.
Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4
Mol. Cell. Biol.
28
3437-3445
2008
Mus musculus
Manually annotated by BRENDA team
Sanchez-Blazquez, P.; Rodriguez-Munoz, M.; Montero, C.; de la Torre-Madrid, E.; Garzon, J.
Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein
Neuropharmacology
54
319-330
2008
Mus musculus
Manually annotated by BRENDA team
Skibinska-Kijek, A.; Radwanska, A.; Kossut, M.
Alpha calcium/calmodulin dependent protein kinase II in learning-dependent plasticity of mouse somatosensory cortex
Neuroscience
151
750-757
2008
Mus musculus
Manually annotated by BRENDA team
Zhang, G.R.; Cheng, X.R.; Zhou, W.X.; Zhang, Y.X.
Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of SAMP8 mice is modulated by anti-Alzheimers disease drugs
Neuroscience
159
308-315
2008
Mus musculus (P11798), Mus musculus
Manually annotated by BRENDA team
Luo, F.; Yang, C.; Chen, Y.; Shukla, P.; Tang, L.; Wang, L.X.; Wang, Z.J.
Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II
J. Pharmacol. Exp. Ther.
325
267-275
2008
Mus musculus
Manually annotated by BRENDA team
Chen, Y.; Luo, F.; Yang, C.; Kirkmire, C.M.; Wang, Z.J.
Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice
J. Pharmacol. Exp. Ther.
330
650-659
2009
Mus musculus
Manually annotated by BRENDA team
Matsumoto, S.; Murozono, M.; Nagaoka, D.; Matsuoka, S.; Takeda, A.; Narita, H.; Watanabe, S.; Isshiki, A.; Watanabe, Y.
Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains
Neurochem. Res.
33
2302-2309
2008
Mus musculus
Manually annotated by BRENDA team
Choi, Y.H.; Ann, E.J.; Yoon, J.H.; Mo, J.S.; Kim, M.Y.; Park, H.S.
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability
Biochim. Biophys. Acta
1833
69-79
2013
Mus musculus (P08414)
Manually annotated by BRENDA team
Hoffman, L.; Stein, R.A.; Colbran, R.J.; Mchaourab, H.S.
Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation
EMBO J.
30
1251-1262
2011
Caenorhabditis elegans (O62305), Mus musculus (P11798)
Manually annotated by BRENDA team
Coultrap, S.J.; Buard, I.; Kulbe, J.R.; DellAcqua, M.L.; Bayer, K.U.
CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin
J. Biol. Chem.
285
17930-17937
2010
Mus musculus
Manually annotated by BRENDA team
Li, W.; Li, H.; Sanders, P.N.; Mohler, P.J.; Backs, J.; Olson, E.N.; Anderson, M.E.; Grumbach, I.M.
The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21
J. Biol. Chem.
286
7990-7999
2011
Mus musculus (Q6PHZ2)
Manually annotated by BRENDA team
Sierra, A.; Zhu, Z.; Sapay, N.; Sharotri, V.; Kline, C.F.; Luczak, E.D.; Subbotina, E.; Sivaprasadarao, A.; Snyder, P.M.; Mohler, P.J.; Anderson, M.E.; Vivaudou, M.; Zingman, L.V.; Hodgson-Zingman, D.M.
Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II
J. Biol. Chem.
288
1568-1581
2013
Mus musculus
Manually annotated by BRENDA team
Medvedev, S.; Stein, P.; Schultz, R.M.
Specificity of calcium/calmodulin-dependent protein kinases in mouse egg activation
Cell Cycle
13
1482-1488
2014
Mus musculus (Q923T9), Mus musculus
Manually annotated by BRENDA team
Bele, T.; Fabbretti, E.
The scaffold protein calcium/calmodulin-dependent serine protein kinase controls ATP release in sensory ganglia upon P2X3 receptor activation and is part of an ATP keeper complex
J. Neurochem.
138
587-597
2016
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Kool, M.; Van De Bree, J.; Bodde, H.; Elgersma, Y.; Van Woerden, G.
The molecular, temporal and region-specific requirements of the beta isoform of calcium/calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion
Sci. Rep.
6
26989
2016
Mus musculus (P28652), Mus musculus, Mus musculus C57BL/6 (P28652)
Manually annotated by BRENDA team
Tetenborg, S.; Yadav, S.C.; Hormuzdi, S.G.; Monyer, H.; Janssen-Bienhold, U.; Dedek, K.
Differential distribution of retinal Ca2+/calmodulin-dependent kinase II (CaMKII) isoforms indicates CaMKII-beta and -delta as specific elements of electrical synapses made of connexin36 (Cx36)
Front. Mol. Neurosci.
10
425
2017
Mus musculus (P28652), Mus musculus (Q6PHZ2)
Manually annotated by BRENDA team