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Information on EC 2.7.11.17 - Ca2+/calmodulin-dependent protein kinase
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2.7.11.17 Ca2+/calmodulin-dependent protein kinaseIUBMB Comments
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
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Word Map
- 2.7.11.17
- synaptic
- actin
- hippocampal
- myosin
-
camks
- autophosphorylation
- cardiac
-
postsynaptic
-
ca2+-dependent
- nmda
- pkc
-
contractile
- agonist
- synapses
- dendritic
- n-methyl-d-aspartate
- tropomyosin
-
amp-activated
- calponin
-
calmodulin-binding
-
calcium-dependent
- calcineurin
-
excitatory
- myocytes
-
l-type
- desmin
-
signal-regulated
- actomyosin
-
activity-dependent
- sarcoplasmic
- gizzard
-
presynaptic
-
element-binding
-
glutamatergic
-
actin-binding
- phosphopeptide
-
ryanodine
-
cam-binding
- phospholamban
- ca2+-calmodulin
- calmidazolium
-
nonmuscle
-
actin-activated
-
ca2+-calmodulin-dependent
- mlck
- trifluoperazine
- meromyosin
-
myosin-binding
-
ampars
-
actin-myosin
- medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
caldesmon, cam kinase ii, camkiv, cam kinase, calcium/calmodulin-dependent protein kinase ii, calmodulin-dependent protein kinase, camkk2, calcium/calmodulin-dependent protein kinase, ca2+/calmodulin-dependent protein kinase, camk ii, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CAKI
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-
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caldesmon
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-
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-
Calspermin
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-
-
-
CAM kinase-GR
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-
-
-
CMPK
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-
-
-
kinase, caldesmon (phosphorylating)
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-
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kinase, microtubule-associated protein 2 (phosphorylating)
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-
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MAP kinase
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-
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MAP-2 kinase
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-
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MAP-2 protein serine kinase
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-
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microtubule associated protein kinase
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-
-
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microtubule-associated protein 2 kinase
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-
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peripheral plasma membrane protein CaMGUK
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
sequential reaction mechanism in which all substrates bind to enzyme before any product is released. Binding of phospholamban to the enzyme decreases the affinity of the enzyme toward ATP
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
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CAS REGISTRY NUMBER
COMMENTARY
141467-21-2
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93229-57-3
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97350-82-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + biotinylated Thr-Arg-Ser-Ala-Ile-Arg-Arg-Ala-Ser-Thr-Ile-Glu-Met-Pro-Gln-Gln-Ala-Arg-Gln
ADP + biotinylated Thr-Arg-Ser-Ala-Ile-Arg-Arg-Ala-Ser-phospho-Thr-Ile-Glu-Met-Pro-Gln-Gln-Ala-Arg-Gln
biotinylated phospholamban Thr17 peptide substrate
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ADP
product inhibition is best fit with an ordered Bi Bi mechanism in which phospholamban is the first substrate to bind and ADP is the last product to be released. Competitive inhibition versus ATP, uncompetitive inhibition versus phospholamban, isoenzyme CaMK IIbeta
biotinylated Thr-Arg-Ser-Ala-Ile-Arg-Arg-Ala-Ser-Thr-Ile-Glu-Met-Pro-Gln-Gln-Ala-Arg-Gln
product inhibition is best fit with an Ordered Bi Bi mechanism in which phospholamban is the first substrate to bind and ADP is the last product to be released. Competitive inhibition versus phospholamban and ATP, isoenzyme CaMK IIbeta
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
CaMK4 Promotes Abortion-related Th17 Cell Imbalance by Activating AKT/mTOR Signaling Pathway.
Acidosis
Acidosis alters the phosphorylation of Ser16 and Thr17 of phospholamban in rat cardiac muscle.
Acidosis
Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis.
Acidosis
Caldesmon and heat shock protein 20 phosphorylation in nitroglycerin- and magnesium-induced relaxation of swine carotid artery.
Acidosis
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Adenocarcinoma
A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression.
Adenocarcinoma
Association of pretherapeutic expression of chemotherapy-related genes with response to neoadjuvant chemotherapy in Barrett carcinoma.
Adenocarcinoma
Differential expression of high molecular weight caldesmon in colorectal pericryptal fibroblasts and tumour stroma.
Adenocarcinoma
Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase.
Adenocarcinoma
Smoothelin and caldesmon are reliable markers for distinguishing muscularis propria from desmoplasia: a critical distinction for accurate staging colorectal adenocarcinoma.
Adenocarcinoma
The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas.
Adenocarcinoma
[Prediction of response to neoadjuvant chemotherapy in Barrett's carcinoma by quantitative gene expression analysis]
Adenoma
Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways.
Adenoma
High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions.
Adenoma
Monoclonal antibodies to cytoskeletal proteins: an immunohistochemical investigation of human colon cancer.
Adenomatoid Tumor
Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases.
Adenoviridae Infections
Gene delivery of l-caldesmon protects cytoskeletal cell membrane integrity against adenovirus infection independently of myosin ATPase and actin assembly.
Albuminuria
Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/?-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria.
Alzheimer Disease
A Comprehensive Analysis of the CaMK2A Gene and Susceptibility to Alzheimer's Disease in the Han Chinese Population.
Alzheimer Disease
Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons.
Alzheimer Disease
Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway.
Alzheimer Disease
Chrysophanol improves memory ability of d-galactose and A?25-35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM-CaMKIV signal pathway in hippocampus.
Alzheimer Disease
Development and validation of a sensitive entropy-based measure for the water maze.
Alzheimer Disease
Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease.
Alzheimer Disease
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.
Alzheimer Disease
Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats.
Alzheimer Disease
Granisetron Alleviates Alzheimer's Disease Pathology in TgSwDI Mice Through Calmodulin-Dependent Protein Kinase II/cAMP-Response Element Binding Protein Pathway.
Alzheimer Disease
Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease.
Alzheimer Disease
In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease.
Alzheimer Disease
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.
Alzheimer Disease
Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.
Alzheimer Disease
Oligomers of Amyloid ? Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease.
Alzheimer Disease
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
Alzheimer Disease
The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology.
Amnesia
Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex, and amygdala in response to spatial learning, predator exposure, and stress-induced amnesia.
Amnesia
The involvement of Ca2+/calmodulin-dependent protein kinase in memory formation in day-old chicks.
Amnesia, Retrograde
Intrahippocampal or intraamygdala infusion of KN62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, causes retrograde amnesia in the rat.
Amnesia, Retrograde
Learning-specific, time-dependent increases in hippocampal Ca2+/calmodulin-dependent protein kinase II activity and AMPA GluR1 subunit immunoreactivity.
Amnesia, Retrograde
Stimulators of the cAMP cascade reverse amnesia induced by intra-amygdala but not intrahippocampal KN-62 administration.
Amyotrophic Lateral Sclerosis
Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies.
Amyotrophic Lateral Sclerosis
Postsynaptic Alteration of NR2A Subunit and Defective Autophosphorylation of alphaCaMKII at Threonine-286 Contribute to Abnormal Plasticity and Morphology of Upper Motor Neurons in Presymptomatic SOD1G93A Mice, a Murine Model for Amyotrophic Lateral Sclerosis.
Anemia, Neonatal
Phlebotomy-induced anemia alters hippocampal neurochemistry in neonatal mice.
Angelman Syndrome
Ca2+/Calmodulin-dependent Protein Kinase II? (?CaMKII) Controls the Activity of the Dopamine Transporter: IMPLICATIONS FOR ANGELMAN SYNDROME.
Angelman Syndrome
Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.
Arrhythmias, Cardiac
A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.
Arrhythmias, Cardiac
ADAMTS13 Deficiency Shortens the Life Span of Mice With Experimental Diabetes.
Arrhythmias, Cardiac
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Arrhythmias, Cardiac
Effects of Wenxin Keli on Cardiac Hypertrophy and Arrhythmia via Regulation of the Calcium/Calmodulin Dependent Kinase II Signaling Pathway.
Arrhythmias, Cardiac
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Arrhythmias, Cardiac
MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKII?.
Arrhythmias, Cardiac
Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits.
Arrhythmias, Cardiac
Regulatory mechanism of calcium/calmodulin-dependent protein kinase II in the occurrence and development of ventricular arrhythmia (Review).
Arrhythmias, Cardiac
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia.
Arrhythmias, Cardiac
Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase II?c transgenic mice.
Arrhythmias, Cardiac
Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction.
Atherosclerosis
Identification of Four Potential Biomarkers Associated With Coronary Artery Disease in Non-diabetic Patients by Gene Co-expression Network Analysis.
Atherosclerosis
Modulation of human aorta smooth muscle cell phenotype: a study of muscle-specific variants of vinculin, caldesmon, and actin expression.
Atrial Fibrillation
Calcium/calmodulin-dependent protein kinase II causes atrial structural remodeling associated with atrial fibrillation and heart failure.
Autoimmune Diseases
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.
Autoimmune Diseases
CaMK4 Promotes Abortion-related Th17 Cell Imbalance by Activating AKT/mTOR Signaling Pathway.
Autoimmune Diseases
CaMK4-dependent activation of AKT/mTOR and CREM-? underlies autoimmunity-associated Th17 imbalance.
Blister
A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly.
Blister
Tropomyosin and caldesmon regulate cytokinesis speed and membrane stability during cell division.
Bone Neoplasms
The inhibitor of calcium/calmodulin-dependent protein kinase II KN93 attenuates bone cancer pain via inhibition of KIF17/NR2B trafficking in mice.
Bone Resorption
Afamin stimulates osteoclastogenesis and bone resorption via Gi-coupled receptor and Ca2+/calmodulin-dependent protein kinase (CaMK) pathways.
Bone Resorption
Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).
Bone Resorption
Cav1.3 is upregulated in osteoporosis rat model and promotes osteoclast differentiation from preosteoclast cell line RAW264.7.
Bradycardia
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Brain Diseases
A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly.
Brain Injuries
Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke.
Brain Injuries
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase ? Is Detrimental in Hypoxia?Ischemia Neonatal Brain Injury.
Brain Injuries
Ischemic brain injury selectively alters ATP binding of calcium and calmodulin-dependent protein kinase II.
Brain Injuries
Persistent translocation of Ca2+/calmodulin-dependent protein kinase II to synaptic junctions in the vulnerable hippocampal CA1 region following transient ischemia.
Brain Injuries
Phosphorylation of calcium calmodulin-dependent protein kinase II following lateral fluid percussion brain injury in rats.
Brain Injuries
TRPM7 Mediates Neuronal Cell Death Upstream of Calcium/Calmodulin-Dependent Protein Kinase II and Calcineurin Mechanism in Neonatal Hypoxic-Ischemic Brain Injury.
Brain Injuries, Traumatic
Calponin and caldesmon cellular domains in reacting microvessels following traumatic brain injury.
Brain Injuries, Traumatic
Increased Expression of Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Delta after Rat Traumatic Brain Injury.
Brain Ischemia
Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha) reversibly targets to and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in cerebral ischemia and reperfusion in hippocampus of rats.
Brain Ischemia
Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats.
Brain Ischemia
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Brain Ischemia
Calcium/calmodulin dependent protein kinase II mRNA in the gerbil brain after cerebral ischemia.
Brain Ischemia
Calcium/calmodulin-dependent kinase II facilitated GluR6 subunit serine phosphorylation through GluR6-PSD95-CaMKII signaling module assembly in cerebral ischemia injury.
Brain Ischemia
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
Brain Ischemia
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
Brain Ischemia
Effect of cerebral ischemia on calcium/calmodulin-dependent protein kinase II activity and phosphorylation.
Brain Ischemia
Glutamate-induced loss of Ca2+/calmodulin-dependent protein kinase II activity in cultured rat hippocampal neurons.
Brain Ischemia
In vivo inhibition of hippocampal Ca2+/calmodulin-dependent protein kinase II by RNA interference.
Brain Ischemia
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase ? and Calcium/Calmodulin-Dependent Protein Kinase IV Is Detrimental in Cerebral Ischemia.
Brain Ischemia
Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains.
Brain Ischemia
Postsynaptic density protein 95 mediates Ca2+/calmodulin-dependent protein kinase II-activated serine phosphorylation of neuronal nitric oxide synthase during brain ischemia in rat hippocampus.
Brain Ischemia
Role of calcium in inactivation of calcium/calmodulin dependent protein kinase II after cerebral ischemia.
Brain Neoplasms
Identification of tumor-related proteins by proteomic analysis of cerebrospinal fluid from patients with primary brain tumors.
Brain Neoplasms
Microvascular proliferation of brain metastases mimics glioblastomas in squash cytology.
Brain Neoplasms
Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.
Breast Neoplasms
Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer.
Breast Neoplasms
Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer.
Breast Neoplasms
Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.
Breast Neoplasms
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
Breast Neoplasms
cGMP-dependent Protein Kinase I? Regulates Breast Cancer Cell Migration and Invasion via a Novel Interaction with the Actin/Myosin-associated Protein Caldesmon.
Breast Neoplasms
Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.
Breast Neoplasms
Inhibition of the CaM-Kinases Augments Cell Death in Response to Oxygen Radicals and Oxygen Radical Inducing Cancer Therapies in MCF-7 Human Breast Cancer Cells.
Breast Neoplasms
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells.
Breast Neoplasms
The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer.
Burkitt Lymphoma
A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1.
Burkitt Lymphoma
Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon.
ca2+/calmodulin-dependent protein kinase deficiency
Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
ca2+/calmodulin-dependent protein kinase deficiency
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.
ca2+/calmodulin-dependent protein kinase deficiency
Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.
ca2+/calmodulin-dependent protein kinase deficiency
Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.
ca2+/calmodulin-dependent protein kinase deficiency
Hypomorphic CAMKK2 in EA.hy926 endothelial cells causes abnormal transferrin trafficking, iron homeostasis and glucose metabolism.
ca2+/calmodulin-dependent protein kinase deficiency
Impaired memory of eyeblink conditioning in CaMKIV KO mice.
ca2+/calmodulin-dependent protein kinase deficiency
Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.
ca2+/calmodulin-dependent protein kinase deficiency
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
ca2+/calmodulin-dependent protein kinase deficiency
The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus.
ca2+/calmodulin-dependent protein kinase deficiency
The Influence of Thyroid Hormone on Ca2+ Signaling Pathways during Embryonal Development.
Carcinogenesis
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Carcinogenesis
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
Carcinogenesis
Genome wide DNA differential methylation regions in colorectal cancer patients in relation to blood related family members, obese and non-obese controls - a preliminary report.
Carcinogenesis
Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer.
Carcinogenesis
Organelle-derived acetyl-CoA promotes prostate cancer cell survival, migration, and metastasis via activation of calmodulin kinase II.
Carcinogenesis
Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma.
Carcinoma
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Carcinoma
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
Carcinoma
CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma.
Carcinoma
CD10 imunostaining does not distinguish endometrial carcinoma invading myometrium from carcinoma involving adenomyosis.
Carcinoma
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
Carcinoma
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Carcinoma
High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions.
Carcinoma
Identification and purification of Ca2+/calmodulin-dependent protein kinase V from human gastric carcinoma.
Carcinoma
Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) .
Carcinoma
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
Carcinoma
Overexpression of caldesmon is associated with tumor progression in patients with primary non-muscle-invasive bladder cancer.
Carcinoma
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
Carcinoma
The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas.
Carcinoma
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
Carcinoma
Thyroid hormone-dependent gene expression in differentiated embryonic stem cells and embryonal carcinoma cells: identification of novel thyroid hormone target genes by deoxyribonucleic acid microarray analysis.
Carcinoma, Endometrioid
CD10 imunostaining does not distinguish endometrial carcinoma invading myometrium from carcinoma involving adenomyosis.
Carcinoma, Hepatocellular
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Carcinoma, Hepatocellular
CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation.
Carcinoma, Hepatocellular
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
Carcinoma, Hepatocellular
CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins.
Carcinoma, Hepatocellular
Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.
Carcinoma, Hepatocellular
Enhanced expression and activation of Ca(2+)/calmodulin-dependent protein kinase IV in hepatocellular carcinoma.
Carcinoma, Hepatocellular
High molecular weight caldesmon positive stromal cells in the capsule of hepatocellular carcinomas.
Carcinoma, Non-Small-Cell Lung
Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase.
Carcinoma, Ovarian Epithelial
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Carcinoma, Renal Cell
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
Carcinoma, Squamous Cell
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
Cardio-Renal Syndrome
An Overview of the Role of Calcium/Calmodulin-Dependent Protein Kinase in Cardiorenal Syndrome.
Cardiomegaly
?IV-spectrin regulates STAT3 targeting to tune cardiac response to pressure overload.
Cardiomegaly
Activation of the Cardiac Renin-Angiotensin System in High Oxygen-Exposed Newborn Rats: Angiotensin Receptor Blockade Prevents the Developmental Programming of Cardiac Dysfunction.
Cardiomegaly
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.
Cardiomegaly
CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo.
Cardiomegaly
CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.
Cardiomegaly
CaMKIIdelta orchestrates G protein coupled receptor and electric field stimulation-induced cardiomyocyte hypertrophy.
Cardiomegaly
Cardiac Hypertrophy and Heart Failure Development Through Gq and CaM Kinase II Signaling.
Cardiomegaly
Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy.
Cardiomegaly
Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.
Cardiomegaly
Expression of Ca2+/calmodulin-dependent protein kinase II delta-subunit isoforms in rats with hypertensive cardiac hypertrophy.
Cardiomegaly
Inhibition of cardiac hypertrophy by probiotic-fermented purple sweet potato yogurt in spontaneously hypertensive rat hearts.
Cardiomegaly
Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells.
Cardiomegaly
Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.
Cardiomegaly
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Cardiomegaly
Roles of calcineurin and calcium/calmodulin-dependent protein kinase II in pressure overload-induced cardiac hypertrophy.
Cardiomegaly
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Cardiomegaly
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.
Cardiomegaly
The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats.
Cardiomegaly
Type III Transforming Growth Factor-? Receptor Drives Cardiac Hypertrophy Through ?-Arrestin2-Dependent Activation of Calmodulin-Dependent Protein Kinase II.
Cardiomegaly
[Oxidative stress and calcium/calmodulin-dependent protein kinase II contribute to the development of sustained ? adrenergic receptor-stimulated cardiac hypertrophy in rats].
Cardiomyopathies
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Cardiomyopathies
Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.
Cardiomyopathies
Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein.
Cardiomyopathies
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Cardiomyopathies
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy.
Cardiomyopathy, Dilated
Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.
Cardiomyopathy, Dilated
Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy.
Cardiomyopathy, Dilated
Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic
The Role of Calcium/Calmodulin-Dependent Protein Kinase II Activation in Hypertrophic Cardiomyopathy.
Cardiotoxicity
Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II.
Cardiovascular Diseases
RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation.
Cerebrovascular Disorders
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Cholera
Ca2+/calmodulin-dependent protein kinase II is an essential mediator in the coordinated regulation of electrocyte Ca2+-ATPase by calmodulin and protein kinase A.
Cholera
Regulation of phospholipase D and secretion in mast cells by protein kinase A and other protein kinases.
Chorea
A Neurodevelopmental Disorder With Dystonia and Chorea Resulting From Clustering CAMK4 Variants.
Choriocarcinoma
Calcium/calmodulin-dependent kinase inhibitor induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells.
Choriocarcinoma
Retraction Note to: Calcium/calmodulin-dependent kinase inhibitor induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells.
Colitis
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.
Colitis
Calcium/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis.
Colitis
CaM kinase II in colonic smooth muscle contributes to dysmotility in murine DSS-colitis.
Colitis
Changes in the Expression of Smooth Muscle Contractile Proteins in TNBS- and DSS-Induced Colitis in Mice.
Colitis, Ulcerative
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.
Colitis-Associated Neoplasms
CAMK2? in intestinal epithelial cells modulates colitis-associated colorectal carcinogenesis via enhancing STAT3 activation.
Colonic Neoplasms
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases.
Colorectal Neoplasms
Caldesmon is useful in demonstrating extramural venous invasion in colorectal carcinomas showing mucinous differentiation.
Communicable Diseases
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.
Congenital Hypothyroidism
Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.
Corticobasal Degeneration
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
COVID-19
Complement activation and increased expression of Syk, mucin-1 and CaMK4 in kidneys of patients with COVID-19.
COVID-19
Olfactory Bulb and Amygdala Gene Expression Changes in Subjects Dying with COVID-19.
Cystadenoma
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Cystic Fibrosis
Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase.
Cystic Fibrosis
Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues.
Death, Sudden, Cardiac
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Dehydration
Abscisic Acid Inhibits Rice Protein Phosphatase PP45 via H2O2 and Relieves Repression of the Ca2+/CaM-Dependent Protein Kinase DMI3.
Dementia, Vascular
[The changes of resting [Ca2+]i level and expression of CaM mRNA, CaMPK II mRNA in hippocampal neurons of the mice with vascular dementia].
Dengue
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.
Diabetes Mellitus
Diabetes mellitus affects activity of calcium/calmodulin-dependent protein kinase II alpha in rat trigeminal ganglia.
Diabetes Mellitus
Sex differences in pain-related behavior and expression of calcium/calmodulin-dependent protein kinase II in dorsal root ganglia of rats with diabetes type 1 and type 2.
Diabetes Mellitus
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Type 1
Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes.
Diabetes Mellitus, Type 2
Cutaneous expression of calcium/calmodulin-dependent protein kinase II in rats with type 1 and type 2 diabetes.
Diabetes Mellitus, Type 2
Exendin-4 stimulates autophagy in pancreatic ?-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis.
Diabetes Mellitus, Type 2
Expression of Calcium/Calmodulin-Dependent Protein Kinase II and Pain-Related Behavior in Rat Models of Type 1 and Type 2 Diabetes.
Diabetes Mellitus, Type 2
Human islets of Langerhans express the delta(C) isoform of calcium/calmodulin-dependent protein kinase II.
Diabetes Mellitus, Type 2
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
Diabetes Mellitus, Type 2
Role of CaMKII in the regulation of fatty acids and lipid metabolism.
Diabetes Mellitus, Type 2
The expression of calcium/calmodulin-dependent protein kinase II in the dorsal horns of rats with type 1 and type 2 diabetes.
Diabetes Mellitus, Type 2
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetic Nephropathies
Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes.
Diabetic Nephropathies
Association of rs 3807337 polymorphism of CALD1 gene with diabetic nephropathy occurrence in type 1 diabetes - preliminary results of a family-based study.
Diabetic Nephropathies
Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice.
Diabetic Nephropathies
Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells.
Diabetic Neuropathies
Expression of Calcium/Calmodulin-Dependent Protein Kinase II and Pain-Related Behavior in Rat Models of Type 1 and Type 2 Diabetes.
Diabetic Neuropathies
Intrathecal inhibition of calcium/calmodulin-dependent protein kinase II in diabetic neuropathy adversely affects pain-related behavior.
Diabetic Neuropathies
The effects of intraganglionic injection of calcium/calmodulin-dependent protein kinase II inhibitors on pain-related behavior in diabetic neuropathy.
Diabetic Retinopathy
Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.
Diabetic Retinopathy
Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas.
Diphtheria
Characterization of Ca2+/calmodulin-dependent protein kinase in rat pancreatic islets.
Dystonia
A Neurodevelopmental Disorder With Dystonia and Chorea Resulting From Clustering CAMK4 Variants.
Embolism
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Embolism
Microsphere embolism-induced changes in noradrenaline release in the cerebral cortex in rats.
Encephalitis
Neurons promote encephalitogenic CD4+ lymphocyte infiltration in experimental autoimmune encephalomyelitis.
Encephalomyelitis
Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice.
Encephalomyelitis
Neuronal Ablation of Alpha/Beta Interferon (IFN-?/?) Signaling Exacerbates Central Nervous System Viral Dissemination and Impairs IFN-? Responsiveness in Microglia/Macrophages.
Encephalomyelitis, Autoimmune, Experimental
Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice.
Endometrial Neoplasms
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
Endometrial Neoplasms
Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas.
Endometrial Stromal Tumors
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Enterocolitis, Necrotizing
Calcium/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis.
Epilepsies, Partial
Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.
Epilepsy
Abnormal changes in voltage-gated sodium channels Na(V)1.1, Na(V)1.2, Na(V)1.3, Na(V)1.6 and in calmodulin/calmodulin-dependent protein kinase II, within the brains of spontaneously epileptic rats and tremor rats.
Epilepsy
Altered calcium/calmodulin kinase II activity changes calcium homeostasis that underlies epileptiform activity in hippocampal neurons in culture.
Epilepsy
Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy.
Epilepsy
Association of UGT2B7 and CaMK4 with response of valproic acid in Chinese children with epilepsy.
Epilepsy
Calmodulin-dependent protein kinase II. Multifunctional roles in neuronal differentiation and synaptic plasticity.
Epilepsy
Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy.
Epilepsy
In vivo inhibition of hippocampal Ca2+/calmodulin-dependent protein kinase II by RNA interference.
Epilepsy
Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation.
Epilepsy
miR-125a-5p alleviates dysfunction and inflammation of pentylenetetrazol-induced epilepsy through targeting calmodulin-dependent protein kinase IV (CAMK4).
Epilepsy
Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity.
Epilepsy
Reversing nerve cell pathology by optimizing modulatory action on target ion channels.
Epilepsy
Severe intellectual disability, absence of language, epilepsy, microcephaly and progressive cerebellar atrophy related to the recurrent de novo variant p.(P139L) of the CAMK2B gene: A case report and brief review.
Epilepsy
The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease.
Epilepsy, Temporal Lobe
Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Reversing nerve cell pathology by optimizing modulatory action on target ion channels.
Essential Hypertension
[Association between gene polymorphism of calcium/calmodulin-dependent kinase 4 and efficacy of amlodipine in the treatment of hypertension in Chinese Han nationality].
Fasciitis
Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue.
Fatty Liver
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Fetal Growth Retardation
Expression of von Willebrand factor and caldesmon in the placental tissues of pregnancies complicated with intrauterine growth restriction.
Fetal Resorption
CaMK4 Promotes Abortion-related Th17 Cell Imbalance by Activating AKT/mTOR Signaling Pathway.
Fibroma
Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue.
Fibroma
Monoclonal antibodies against caldesmon, a Ca++/calmodulin- and actin-binding protein of smooth muscle and nonmuscle cells.
Fragile X Syndrome
Ca2+/calmodulin-dependent protein kinase IV links Group I metabotropic glutamate receptors to FMRP in cingulate cortex.
Frontotemporal Lobar Degeneration
The olfactory bulb proteotype differs across frontotemporal dementia spectrum.
Gastrointestinal Stromal Tumors
[Difficulties in diagnosing and treating GIST: report and analysis of a case]
Glaucoma
Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells.
Glaucoma
Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments.
Glioblastoma
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
Glioblastoma
MiR-1271 regulates glioblastoma cell proliferation and invasion by directly targeting the CAMKK2 gene.
Glioma
5-HT2A receptor activation leads to increased BDNF mRNA expression in C6 glioma cells.
Glioma
Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.
Glioma
Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.
Glioma
CAMKK2, Regulated by Promoter Methylation, is a Prognostic Marker in Diffuse Gliomas.
Glioma
Differential expression of splicing variants of the human caldesmon gene (CALD1) in glioma neovascularization versus normal brain microvasculature.
Glioma
Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells.
Glioma
Involvement of calcium/calmodulin-dependent protein kinase II in the induction of mPer1.
Glioma
MiR-1271 regulates glioblastoma cell proliferation and invasion by directly targeting the CAMKK2 gene.
Glioma
Modulation by calcium/calmodulin-dependent protein kinase II of functional response of delta opioid receptor in neuroblastoma x glioma hybrid (NG108-15) cells.
Glioma
Role of calmodulin-dependent phosphorylation of elongation factor 2 in the proliferation of rat glial cells.
Glioma
Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.
Glioma
[Regulation of Ca2+/calmodulin-dependent protein kinase II in the cell systems in response to cellular stimuli]
Glomerulonephritis
CaMK4 facilitates the recruitment of IL-17-producing cells to target organs through the CCR6/CCL20 axis in Th17-driven inflammatory diseases.
Glomerulonephritis
Enhanced glomerular expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid-heparin therapy.
Glomerulonephritis
Enhanced interstitial expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid-heparin therapy.
Glomerulonephritis, IGA
Enhanced glomerular expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid-heparin therapy.
Glomerulonephritis, IGA
Enhanced interstitial expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid-heparin therapy.
Glomerulosclerosis, Focal Segmental
Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.
Glomerulosclerosis, Focal Segmental
CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
Glomerulosclerosis, Focal Segmental
TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.
Glucose Intolerance
Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
Glucose Intolerance
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
Glucose Intolerance
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
Granulosa Cell Tumor
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Heart Arrest
Isoflurane pretreatment ameliorates postischemic neurologic dysfunction and preserves hippocampal Ca2+/calmodulin-dependent protein kinase in a canine cardiac arrest model.
Heart Diseases
A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.
Heart Diseases
Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease.
Heart Diseases
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy.
Heart Diseases
Dysfunctional ryanodine receptors in the heart: New insights into complex cardiovascular diseases.
Heart Diseases
MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKII?.
Heart Diseases
PP1? functionally augments the alternative splicing of CaMKII? through interaction with ASF.
Heart Diseases
Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca(2+) release events in a rodent model of early stage diabetes: The arrhythmogenic substrate.
Heart Diseases
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
Heart Diseases
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Heart Failure
Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy.
Heart Failure
Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure.
Heart Failure
Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.
Heart Failure
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.
Heart Failure
Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic ?-Adrenoceptor Blockade in Experimental and Human Heart Failure.
Heart Failure
Calcium/calmodulin-dependent protein kinase II causes atrial structural remodeling associated with atrial fibrillation and heart failure.
Heart Failure
Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.
Heart Failure
Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias.
Heart Failure
CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.
Heart Failure
CaMKIIdelta overexpression in hypertrophy and heart failure: cellular consequences for excitation-contraction coupling.
Heart Failure
Cardiac Hypertrophy and Heart Failure Development Through Gq and CaM Kinase II Signaling.
Heart Failure
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.
Heart Failure
Cardiac-specific inhibition of kinase activity in calcium/calmodulin-dependent protein kinase kinase-? leads to accelerated left ventricular remodeling and heart failure after transverse aortic constriction in mice.
Heart Failure
Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure.
Heart Failure
Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure.
Heart Failure
Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure.
Heart Failure
Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits.
Heart Failure
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Heart Failure
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure.
Heart Failure
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
Heart Failure
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
Heart Failure
The Murine Model of Mucopolysaccharidosis IIIB Develops Cardiopathies over Time Leading to Heart Failure.
Heart Failure
[Effects of valsartan on myocardial calcium/calmodulin-dependent protein kinase-II expression and activity in a rabbit model of heart failure]
Heart Rupture
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Hepatitis
Neuronal Ablation of Alpha/Beta Interferon (IFN-?/?) Signaling Exacerbates Central Nervous System Viral Dissemination and Impairs IFN-? Responsiveness in Microglia/Macrophages.
Herpes Simplex
Inhibition of calmodulin-dependent kinase kinase blocks human cytomegalovirus-induced glycolytic activation and severely attenuates production of viral progeny.
Herpes Simplex
Transient viral-mediated overexpression of alpha-calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell leads to long-lasting functional upregulation of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors: dopamine type-1 receptor and protein kinase A dependence.
Herpes Zoster
Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.
Herpes Zoster
Structural requirements for calmodulin binding to membrane-associated guanylate kinase homologs.
Hyperalgesia
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Hyperalgesia
Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia.
Hyperalgesia
Dezocine attenuates the remifentanil-induced postoperative hyperalgesia by inhibition of phosphorylation of CaMK??.
Hyperalgesia
Formalin-induced spinal cord calcium/calmodulin-dependent protein kinase II alpha expression is modulated by heme oxygenase in mice.
Hyperalgesia
Growth Arrest and DNA-damage-inducible Protein 45?-mediated DNA Demethylation of Voltage-dependent T-type Calcium Channel 3.2 Subunit Enhances Neuropathic Allodynia after Nerve Injury in Rats.
Hyperalgesia
Inhibition of CaMKIV relieves streptozotocin-induced diabetic neuropathic pain through regulation of HMGB1.
Hyperalgesia
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
Hyperalgesia
Nicotine reward and affective nicotine withdrawal signs are attenuated in calcium/calmodulin-dependent protein kinase IV knockout mice.
Hyperalgesia
Phosphorylated CaMKII levels increase in rat central nervous system after large-dose intravenous remifentanil.
Hyperalgesia
Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia.
Hyperalgesia
Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation.
Hyperalgesia
Wnt5b/Ryk-mediated membrane trafficking of P2X3 receptors contributes to bone cancer pain.
Hyperglycemia
CaM Kinase II-? Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy.
Hyperglycemia
Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.
Hyperhomocysteinemia
Camk2b protects neurons from homocysteine-induced apoptosis with the involvement of HIF-1? signal pathway.
Hyperkalemia
Works on heart, how about brain? Effect of hyperkalemia on focal cerebral ischemia/reperfusion injury in rats.
Hyperkinesis
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder.
Hypersensitivity
Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons.
Hypertension
Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function.
Hypertension
Functional significance of activation of calcium/calmodulin-dependent protein kinase II in angiotensin II--induced vascular hyperplasia and hypertension.
Hypertension
Inhibition of cardiac hypertrophy by probiotic-fermented purple sweet potato yogurt in spontaneously hypertensive rat hearts.
Hypertension
Mitochondrial fission protein, dynamin-related protein 1, contributes to the promotion of hypertensive cardiac hypertrophy and fibrosis in Dahl-salt sensitive rats.
Hypertension
Redox-sensitive calcium/calmodulin-dependent protein kinase II? in angiotensin II intra-neuronal signaling and hypertension.
Hypertension
Role of calcium/calmodulin-dependent protein kinases in expression of Fos protein in the nucleus tractus solitarii after sustained hypertension.
Hypertension
[Association between gene polymorphism of calcium/calmodulin-dependent kinase 4 and efficacy of amlodipine in the treatment of hypertension in Chinese Han nationality].
Hypertension, Renal
[Effects of qishenyiqi gutta pills on calcium/calmodulin dependent protein kinase II in rats with renal hypertension].
Hyperthyroidism
Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.
Hyperthyroidism
Thyroid hormone downregulates the expression and function of sarcoplasmic reticulum-associated CaM kinase II in the rabbit heart.
Hypertrophy, Left Ventricular
The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats.
Hypothyroidism
A critical role of CREB in the impairment of late-phase LTP by adult onset hypothyroidism.
Hypothyroidism
Chronic Nicotine Treatment Reverses Hypothyroidism-Induced Impairment of L-LTP Induction Phase: Critical Role of CREB.
Hypothyroidism
Developmental Iodine Deficiency and Hypothyroidism Impair Spatial Memory in Adolescent Rat Hippocampus: Involvement of CaMKII, Calmodulin and Calcineurin.
Hypothyroidism
Developmental Iodine Deficiency and Hypothyroidism Reduce Phosphorylation of Calcium/Calmodulin-Dependent Kinase II in the Rat Entorhinal Cortex.
Hypothyroidism
Effect of hypothyroidism on the subcellular distribution of Ca2+/calmodulin-stimulated protein kinase II in chicken brain during posthatch development.
Hypothyroidism
Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats.
Hypothyroidism
Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.
Hypothyroidism
Late Maternal Hypothyroidism Alters the Expression of Camk4 in Neocortical Subplate Neurons: A Comparison with Nurr1 Labeling.
Hypothyroidism
Levothyroxin replacement therapy restores hypothyroidism induced impairment of L-LTP induction: critical role of CREB.
Hypothyroidism
The Influence of Thyroid Hormone on Ca2+ Signaling Pathways during Embryonal Development.
Hypothyroidism
[Effect of iodine deficiency and hypothyroidism on the protein expressions of CaMK II in the hippocampus of pups]
Hypoxia, Brain
Binding studies and biological evaluation of ?-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV.
Hypoxia, Brain
Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Hypoxia, Brain
Effect of hypoxia on calcium influx and calcium/calmodulin-dependent kinase activity in cortical neuronal nuclei of the guinea pig fetus during development.
Hypoxia, Brain
Effect of hypoxia on protein phosphatase 2A activity, subcellular distribution and expression in cerebral cortex of newborn piglets.
Infarction, Middle Cerebral Artery
Calcium/calmodulin-dependent protein kinase kinase ? is neuroprotective in stroke in aged mice.
Infarction, Middle Cerebral Artery
Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion.
Infarction, Middle Cerebral Artery
Simvastatin Pretreatment Protects Cerebrum from Neuronal Injury by Decreasing the Expressions of Phosphor-CaMK II and AQP4 in Ischemic Stroke Rats.
Infections
A dominant function of CCaMK in intracellular accommodation of bacterial and fungal endosymbionts.
Infections
A novel interaction between CCaMK and a protein containing the Scythe_N ubiquitin-like domain in Lotus japonicus.
Infections
A Role for the Non-Canonical Wnt-?-Catenin and TGF-? Signaling Pathways in the Induction of Tolerance during the Establishment of a Salmonella enterica Serovar Enteritidis Persistent Cecal Infection in Chickens.
Infections
Activation of calcium- and calmodulin-dependent protein kinase (CCaMK), the central regulator of plant root endosymbiosis.
Infections
Alteration of Leishmania donovani infection levels by selective impairment of macrophage signal transduction.
Infections
Alteration of microRNA-4474/4717 expression and CREB-binding protein in human colorectal cancer tissues infected with Fusobacterium nucleatum.
Infections
Anti-echinococcal effect of verapamil involving the regulation of the calcium/calmodulin-dependent protein kinase II response in vitro and in a murine infection model.
Infections
Calcium spiking patterns and the role of the calcium/calmodulin-dependent kinase CCaMK in lateral root base nodulation of Sesbania rostrata.
Infections
Capsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2.
Infections
Cellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A protein.
Infections
Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress.
Infections
Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit to Drive Glycolytic Activation and Support Productive Viral Infection.
Infections
Nod Factor-Independent Nodulation in Aeschynomene evenia Required the Common Plant-Microbe Symbiotic Toolkit.
Infections
Nuclear-Localized and Deregulated Calcium- and Calmodulin-Dependent Protein Kinase Activates Rhizobial and Mycorrhizal Responses in Lotus japonicus.
Infections
PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement.
Infections
Porcine Circovirus Type 2 Activates CaMMK? to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium.
Infections
Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brain.
Infections
Rhizobial and Fungal Symbioses Show Different Requirements for Calmodulin Binding to Calcium Calmodulin-Dependent Protein Kinase in Lotus japonicus.
Infections
Rhizobial infection does not require cortical expression of upstream common symbiosis genes responsible for the induction of Ca(2+) spiking.
Infections
Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction.
Infections
Root Hair Deformation of Symbiosis-Deficient Mutants of Lotus japonicus by Application of Nod Factor from Mesorhizobium loti.
Infections
The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models.
Infections
The independent acquisition of plant root nitrogen-fixing symbiosis in Fabids recruited the same genetic pathway for nodule organogenesis.
Infections
Transient overexpression of alpha-Ca2+/calmodulin-dependent protein kinase II in the nucleus accumbens shell enhances behavioral responding to amphetamine.
Infertility, Male
Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV.
Infertility, Male
Novel mutations in calcium/calmodulin-dependent protein kinase IV (CAMK4) gene in infertile men.
Influenza, Human
Transcriptomic signatures of cellular and humoral immune responses in older adults after seasonal influenza vaccination identified by data-driven clustering.
Insulin Resistance
Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
Insulin Resistance
Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects.
Insulin Resistance
Ca2+/calmodulin-dependent protein kinase IV attenuates inflammation and mitochondrial dysfunction under insulin resistance in C2C12 cells.
Insulin Resistance
CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice.
Insulin Resistance
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
Insulin Resistance
In vitro treatment of 3?T3-L1 adipocytes with recombinant Calcium/calmodulin-dependent Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTOR/CREB signaling pathway.
Insulin Resistance
Intravenous sustained-release nifedipine ameliorates nonalcoholic fatty liver disease by restoring autophagic clearance.
Insulin Resistance
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
Insulin Resistance
The cholesterol-lowering agent methyl-?-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice.
Insulin Resistance
Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress.
Insulinoma
Ca2+/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells.
Insulinoma
Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.
Insulinoma
Cloning from insulinoma cells of synapsin I associated with insulin secretory granules.
Insulinoma
Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.
Insulinoma
Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles.
Insulinoma
Overexpression of calcium/calmodulin-dependent protein kinase II in insulinoma cells by use of a retroviral vector.
Insulinoma
Regulation of insulin secretion by overexpression of Ca2+/calmodulin-dependent protein kinase II in insulinoma MIN6 cells.
Intellectual Disability
A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly.
Intellectual Disability
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder.
Intellectual Disability
Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice.
Intellectual Disability
Calcium/calmodulin-dependent serine protein kinase and mental retardation.
Intellectual Disability
De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
Intellectual Disability
Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.
Intellectual Disability
Fragile X Mental Retardation Protein and Dendritic Local Translation of the Alpha Subunit of the Calcium/Calmodulin-Dependent Kinase II Messenger RNA Are Required for the Structural Plasticity Underlying Olfactory Learning.
Intellectual Disability
Role of calcium/calmodulin-dependent kinase 2 in neurodevelopmental disorders.
Intellectual Disability
Severe intellectual disability, absence of language, epilepsy, microcephaly and progressive cerebellar atrophy related to the recurrent de novo variant p.(P139L) of the CAMK2B gene: A case report and brief review.
Intellectual Disability
The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function.
Ischemic Attack, Transient
Baclofen is neuroprotective and prevents loss of calcium/calmodulin-dependent protein kinase II immunoreactivity in the ischemic gerbil hippocampus.
Ischemic Attack, Transient
Calcium/calmodulin dependent protein kinase II mRNA in the gerbil brain after cerebral ischemia.
Ischemic Attack, Transient
Transient cerebral ischemia decreases calcium/calmodulin-dependent protein kinase II immunoreactivity, but not mRNA levels in the gerbil hippocampus.
Kidney Diseases
Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
Kidney Diseases
CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
Kidney Diseases
CaMK4 facilitates the recruitment of IL-17-producing cells to target organs through the CCR6/CCL20 axis in Th17-driven inflammatory diseases.
Leiomyoma
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Leiomyoma
Subungual Leiyomyoma Presenting as Erythronychia: Case Report and Review of the Literature
Leiomyoma
Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal.
Leiomyosarcoma
A tale of two clones: Caldesmon staining in the differentiation of cutaneous spindle cell neoplasms.
Leiomyosarcoma
h-Caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrial stromal sarcoma.
Leiomyosarcoma
Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases.
Leiomyosarcoma
Primary leiomyosarcoma of the pancreas: report of a case treated by local excision and review of the literature.
Leiomyosarcoma
Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract.
Leiomyosarcoma
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity.
Leiomyosarcoma
Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa.
Leukemia
A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.
Leukemia
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Leukemia
Non-selective cation channel-mediated Ca2+-entry and activation of Ca2+/calmodulin-dependent kinase II contribute to G2/M cell cycle arrest and survival of irradiated leukemia cells.
Leukemia
Phosphorylation of CD20 in cells from a hairy cell leukemia cell line. Evidence for involvement of calcium/calmodulin-dependent protein kinase II.
Leukemia
Tumor cell resistance to topoisomerase II poisons: role for intracellular free calcium in the sensitization by inhibitors or calcium-calmodulin-dependent enzymes.
Leukemia, Hairy Cell
Phosphorylation of CD20 in cells from a hairy cell leukemia cell line. Evidence for involvement of calcium/calmodulin-dependent protein kinase II.
Leukemia, Lymphoid
Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Leukemia, Myeloid
Activated Ca2+/calmodulin-dependent protein kinase IIgamma is a critical regulator of myeloid leukemia cell proliferation.
Leukemia, Myeloid
CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells.
Leukemia, Myeloid
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells.
Leukemia, Myeloid
Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors.
Leukemia, Myeloid
The retinoic acid receptor/CaMKII interaction: Pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells.
Leukemia, Myeloid, Acute
A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.
Liver Diseases
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Liver Neoplasms
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
Liver Neoplasms
Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli.
Liver Neoplasms
MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).
Lung Neoplasms
Association of calcium/calmodulin-dependent protein kinase kinase1 rs7214723 polymorphism with lung cancer risk in a Chinese population.
Lung Neoplasms
Ca2+/calmodulin-dependent protein kinase II? enhances stem-like traits and tumorigenicity of lung cancer cells.
Lung Neoplasms
Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase.
Lung Neoplasms
Polymorphism rs7214723 in CAMKK1 and lung cancer risk in Chinese population.
Lung Neoplasms
The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.
Lung Neoplasms
Upregulation of cytoskeleton protein and extracellular matrix protein induced by stromal-derived nitric oxide promotes lung cancer invasion and metastasis.
Lupus Erythematosus, Systemic
Calcium/calmodulin-dependent protein kinase 4 promotes GLUT1-dependent glycolysis in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Lupus.
Lupus Erythematosus, Systemic
Comparative transcriptome analysis reveals a potential role for CaMK4 in ??T17 cells from systemic lupus erythematosus patients with lupus nephritis.
Lupus Erythematosus, Systemic
Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.
Lupus Erythematosus, Systemic
KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3(+) regulatory T cells in MRL/lpr mice.
Lupus Erythematosus, Systemic
Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.
Lupus Erythematosus, Systemic
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV.
Lupus Erythematosus, Systemic
TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.
Lupus Nephritis
CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
Lupus Nephritis
Comparative transcriptome analysis reveals a potential role for CaMK4 in ??T17 cells from systemic lupus erythematosus patients with lupus nephritis.
Lupus Nephritis
Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.
Lupus Nephritis
Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.
Lymphatic Metastasis
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases.
Lymphatic Metastasis
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
Lymphoma
A case report of tracheal inflammatory myofibroblastic tumor in a 34-week pregnant woman misdiagnosed with asthma.
Lymphoma
Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas.
Lymphoma
Inflammatory myofibroblastic tumors of the urinary tract: a clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma.
Lymphoma
Reactive nodular fibrous pseudotumor: A first report of gastric localization and clinicopathologic review.
Lymphoma
The role of caldesmon in the regulation of receptor capping in mouse T-lymphoma cell.
Lymphoma
Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor: A case report and review of the literature.
Lymphoma
[Inflammatory myofibroblastic tumor of bladder: a clinicopathologic study of five cases]
Lymphoma, B-Cell
Calcium/calmodulin-dependent protein kinase kinase ? is neuroprotective in stroke in aged mice.
Lymphoma, Follicular
Differential expression of Ca(2+)-binding proteins on follicular dendritic cells in non-neoplastic and neoplastic lymphoid follicles.
Malaria, Cerebral
CaM kinase II-alpha activity, levels and Ca/calmodulin dependent phosphorylation of substrate proteins in mice brain during fatal murine cerebral malaria.
Massive Hepatic Necrosis
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
Measles
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling.
Medulloblastoma
Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.
Melanoma
CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK?NRF2 Pathway.
Memory Disorders
Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain Amyloidosis.
Memory Disorders
Modulation of hippocampal dopamine and synapse-related proteins by electroacupuncture improves memory deficit caused by sleep deprivation.
Memory Disorders
Neural Activity Changes Underlying the Working Memory Deficit in Alpha-CaMKII Heterozygous Knockout Mice.
Memory Disorders
Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging.
Mental Retardation, X-Linked
Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice.
Mental Retardation, X-Linked
CASK mutations are frequent in males and cause X-linked nystagmus and variable XLMR phenotypes.
Microcephaly
A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly.
Microcephaly
CASK mutations are frequent in males and cause X-linked nystagmus and variable XLMR phenotypes.
Microcephaly
MICrocephaly, disproportionate pontine and cerebellar hypoplasia syndrome: A clinico-radiologic phenotype linked to calcium/calmodulin-dependent serine protein kinase gene mutation.
Microcephaly
Severe intellectual disability, absence of language, epilepsy, microcephaly and progressive cerebellar atrophy related to the recurrent de novo variant p.(P139L) of the CAMK2B gene: A case report and brief review.
Microphthalmos
Robotic wedge resection of a rare gastric perivascular epithelioid cell tumor: A case report.
Microphthalmos
Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum.
Migraine Disorders
Mutated CaV2.1 channels dysregulate CASK/P2X3 signaling in mouse trigeminal sensory neurons of R192Q Cacna1a knock-in mice.
Migraine with Aura
Mutated CaV2.1 channels dysregulate CASK/P2X3 signaling in mouse trigeminal sensory neurons of R192Q Cacna1a knock-in mice.
Mononeuropathies
Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy.
Mononeuropathies
Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy.
Movement Disorders
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder.
Multiple Myeloma
CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti-PD-L1 Treatment.
Muscle Neoplasms
A study of ?5 chain of collagen IV, caldesmon, placental alkaline phosphatase and smoothelin as immunohistochemical markers of gastrointestinal smooth muscle neoplasms.
Muscle Spasticity
Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage.
Muscular Atrophy
Targeted ablation of p38? MAPK suppresses denervation-induced muscle atrophy.
Muscular Atrophy
The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis.
Muscular Diseases
CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation.
Muscular Dystrophy, Duchenne
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
Muscular Dystrophy, Duchenne
CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation.
Mycoses
A dominant function of CCaMK in intracellular accommodation of bacterial and fungal endosymbionts.
Myocardial Infarction
Calcium/Calmodulin-Dependent Protein Kinase II Delta Inhibition and Ventricular Remodeling After Myocardial Infarction: A Randomized Clinical Trial.
Myocardial Infarction
IK1 channel agonist zacopride suppresses ventricular arrhythmias in conscious rats with healing myocardial infarction.
Myocardial Infarction
Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction.
Myocardial Ischemia
Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70.
Nasal Polyps
Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps.
Nasopharyngeal Carcinoma
Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma.
Neoplasm Metastasis
Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells.
Neoplasm Metastasis
Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.
Neoplasm Metastasis
CASK regulates Notch pathway and functions as a tumor promoter in pancreatic cancer.
Neoplasm Metastasis
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases.
Neoplasm Metastasis
Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein.
Neoplasm Metastasis
miR-378c suppresses Wilms tumor development via negatively regulating CAMKK2.
Neoplasm Metastasis
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
Neoplasm Metastasis
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells.
Neoplasm Metastasis
Proteomic Tissue-Based Classifier for Early Prediction of Prostate Cancer Progression.
Neoplasm Metastasis
Upregulation of cytoskeleton protein and extracellular matrix protein induced by stromal-derived nitric oxide promotes lung cancer invasion and metastasis.
Neoplasms
"Pediatric-type" Gastrointestinal Stromal Tumors in Adults: Distinctive Histology Predicts Genotype and Clinical Behavior.
Neoplasms
14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2).
Neoplasms
A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion.
Neoplasms
A giant mesentery malignant solitary fibrous tumor recurring as dedifferentiated liposarcoma- a report of a very rare case and literature review.
Neoplasms
A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression.
Neoplasms
A tale of two clones: Caldesmon staining in the differentiation of cutaneous spindle cell neoplasms.
Neoplasms
Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways.
Neoplasms
Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma.
Neoplasms
Alteration of microRNA-4474/4717 expression and CREB-binding protein in human colorectal cancer tissues infected with Fusobacterium nucleatum.
Neoplasms
Androgen Receptor Expression in Adenoid Cystic Carcinoma of Breast: A Subset of Seven Cases.
Neoplasms
Anticancer and Cytotoxic activities of [Cu(C6H16N2O2)2][Ni(CN)4] and [Cu(C6H16N2O2)Pd(CN)4] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines.
Neoplasms
Association of pretherapeutic expression of chemotherapy-related genes with response to neoadjuvant chemotherapy in Barrett carcinoma.
Neoplasms
Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma".
Neoplasms
Bacoside A Induces Tumor Cell Death in Human Glioblastoma Cell Lines through Catastrophic Macropinocytosis.
Neoplasms
Binding studies and biological evaluation of ?-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV.
Neoplasms
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Neoplasms
Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma.
Neoplasms
Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt.
Neoplasms
Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology.
Neoplasms
Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.
Neoplasms
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
Neoplasms
Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.
Neoplasms
CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation.
Neoplasms
CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer.
Neoplasms
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
Neoplasms
CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK?NRF2 Pathway.
Neoplasms
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
Neoplasms
CD34-positive stromal cells and alpha-smooth muscle actin-positive stromal cells in the tumor capsule of skin sweat gland neoplasms.
Neoplasms
Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation.
Neoplasms
Characterization of the leiomyomatous variant of myofibroblastoma: a rare subset distinct from other smooth muscle tumors of the breast.
Neoplasms
Clinicopathologic study of primary malignant gastrointestinal stromal tumor of the stomach, with special reference to prognostic factors: analysis of results in 140 surgically resected patients.
Neoplasms
Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroups.
Neoplasms
Concurrent occurrence of primary intracranial Epstein-Barr virus-associated leiomyosarcoma and Hodgkin lymphoma in a young adult.
Neoplasms
Dermatofibrosarcoma Protuberans-Like Tumor With COL1A1 Copy Number Gain in the Absence of t(17;22).
Neoplasms
Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Neoplasms
Differential expression of Hela-type caldesmon in tumour neovascularization: a new marker of angiogenic endothelial cells.
Neoplasms
Differential expression of high molecular weight caldesmon in colorectal pericryptal fibroblasts and tumour stroma.
Neoplasms
Differential involvement of calmodulin-dependent protein kinase II-activated AP-1 and c-Jun N-terminal kinase-activated EGR-1 signaling pathways in tumor necrosis factor-alpha and lipopolysaccharide-induced CD44 expression in human monocytic cells.
Neoplasms
Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.
Neoplasms
Effect of pH on the structure, function, and stability of human calcium/calmodulin-dependent protein kinase IV: combined spectroscopic and MD simulation studies.
Neoplasms
Enhanced expression and activation of Ca(2+)/calmodulin-dependent protein kinase IV in hepatocellular carcinoma.
Neoplasms
Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK.
Neoplasms
Epstein-Barr virus associated smooth muscle tumors. Synchronous liver and lung involvement.
Neoplasms
Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling.
Neoplasms
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
Neoplasms
Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice.
Neoplasms
Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer.
Neoplasms
Fibroblasts play a potential role in bone destruction via osteopontin related caldesmon expression and polymerization in human non-functioning pituitary adenomas.
Neoplasms
Fibronexus in "malignant fibrous histiocytoma" of the bone: a case report of pleomorphic myofibrosarcoma.
Neoplasms
Gastric Plexiform Fibromyxoma: A Great Mimic of Gastrointestinal Stromal Tumor (GIST) and Diagnostic Pitfalls.
Neoplasms
Genome-wide disease association study in chewing tobacco associated oral cancers.
Neoplasms
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
Neoplasms
h-Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors.
Neoplasms
h-Caldesmon as a specific marker of smooth muscle cell differentiation in some soft tissue tumors of the skin.
Neoplasms
Hela l-CaD is implicated in the migration of endothelial cells/endothelial progenitor cells in human neoplasms.
Neoplasms
Hesperidin-CAMKIV interaction and its impact on cell proliferation and apoptosis in the human hepatic carcinoma and neuroblastoma cells.
Neoplasms
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Neoplasms
High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions.
Neoplasms
High throughput screening, docking and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Neoplasms
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases.
Neoplasms
Identification of an N-terminal amino acid of the CLC-3 chloride channel critical in phosphorylation-dependent activation of a CaMKII-activated chloride current.
Neoplasms
Identification of Potential Inhibitors of Calcium/Calmodulin-Dependent Protein Kinase IV from Bioactive Phytoconstituents.
Neoplasms
Implication and Regulation of AMPK during Physiological and Pathological Myeloid Differentiation.
Neoplasms
Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up.
Neoplasms
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling.
Neoplasms
Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells.
Neoplasms
Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.
Neoplasms
Intraarticular Nodular Fasciitis-A Rare Lesion: Clinicopathologic Analysis of a Series.
Neoplasms
Ketamine inhibits aerobic glycolysis in colorectal cancer cells by blocking the NMDA receptor-CaMK II-c-Myc pathway.
Neoplasms
Leiomyoblastoma of the uterus: an immunohistochemical and electron microscopic study of distinctive tumours with immature smooth muscle cell differentiation mimicking fetal uterine myocytes.
Neoplasms
Leiomyosarcoma of the broad ligament with osteoclast-like giant cells and rhabdoid cells.
Neoplasms
Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease.
Neoplasms
Low-grade sinonasal sarcoma with neural and myogenic features-diagnostic challenge and pathogenic insight.
Neoplasms
Mesenchymal stem cells regulate cytoskeletal dynamics and promote cancer cell invasion through low dose nitric oxide.
Neoplasms
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Neoplasms
MicroRNA-224 and its target CAMKK2 synergistically influence tumor progression and patient prognosis in prostate cancer.
Neoplasms
Microvascular proliferation of brain metastases mimics glioblastomas in squash cytology.
Neoplasms
MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).
Neoplasms
Monoclonal antibodies to cytoskeletal proteins: an immunohistochemical investigation of human colon cancer.
Neoplasms
Myxoid endometrial stromal sarcoma: report of two cases with emphasis on its diagnostic problems.
Neoplasms
Novel SRF-ICA1L Fusions in Cellular Myoid Neoplasms With Potential For Malignant Behavior.
Neoplasms
Overexpression of caldesmon is associated with tumor progression in patients with primary non-muscle-invasive bladder cancer.
Neoplasms
Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways.
Neoplasms
Parotid Gland Solitary Fibrous Tumor: A Case Report and Clinicopathologic Review of 22 Cases from the Literature.
Neoplasms
Perivascular Epithelioid Cell Tumor of the Uterus with Ovarian Involvement: A Case Report and Review of the Literature.
Neoplasms
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Neoplasms
Phosphorylation of tyrosine hydroxylase on at least three sites in rat pheochromocytoma PC12 cells treated with 56 mM K+: determination of the sites on tyrosine hydroxylase phosphorylated by cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases.
Neoplasms
Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice.
Neoplasms
Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases.
Neoplasms
Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.
Neoplasms
Primary leiomyosarcoma of the pancreas: report of a case treated by local excision and review of the literature.
Neoplasms
Primary pure spindle cell carcinoma (sarcomatoid carcinoma) of the ovary: A case report with immunohistochemical study.
Neoplasms
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
Neoplasms
Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy.
Neoplasms
Proteasome inhibitors induce AMPK activation via CaMKK? in human breast cancer cells.
Neoplasms
Recombinant human tumor necrosis factor alpha induces calcium oscillation and calcium-activated chloride current in human neutrophils. The role of calcium/calmodulin-dependent protein kinase.
Neoplasms
Robotic wedge resection of a rare gastric perivascular epithelioid cell tumor: A case report.
Neoplasms
Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum.
Neoplasms
Smoothelin and caldesmon are reliable markers for distinguishing muscularis propria from desmoplasia: a critical distinction for accurate staging colorectal adenocarcinoma.
Neoplasms
Spindle cell/sclerosing rhabdomyosarcoma: case series from a single institution emphasizing morphology, immunohistochemistry and follow-up.
Neoplasms
Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.
Neoplasms
Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal.
Neoplasms
Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas.
Neoplasms
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.
Neoplasms
The effect of phorbol esters on the expression of mRNA for the alpha subunit of calcium/calmodulin dependent protein kinase II in rabbit renal proximal tubules.
Neoplasms
The Pathway to Cancer Cachexia: MicroRNA-Regulated Networks in Muscle Wasting Based on Integrative Meta-Analysis.
Neoplasms
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
Neoplasms
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells.
Neoplasms
Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor: A case report and review of the literature.
Neoplasms
Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer.
Neoplasms
Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2.
Neoplasms
Uterine retiform sertoli-leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors.
Neoplasms
[Clinicopathological characterization of primary pulmonary and tracheal glomus tumors].
Neoplasms
[Gastrointestinal glomus tumors: a clinicopathological analysis of fifteen cases].
Neoplasms
[Inflammatory myofibroblastic tumor of bladder: a clinicopathologic study of five cases]
Neoplasms
[Prediction of response to neoadjuvant chemotherapy in Barrett's carcinoma by quantitative gene expression analysis]
Nephritis
Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.
Nephritis
IL-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation.
Nephritis
Inhibition of calcium/calmodulin-dependent protein kinase type IV results in suppression of autoimmunity and organ pathology in lupus-prone mice.
Nephrotic Syndrome
Inhibition of calcium(2+)/calmodulin-dependent protein kinase type IV ameliorates experimental nephrotic syndrome.
Nervous System Diseases
A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.
Nervous System Diseases
A novel CASK mutation identified in siblings exhibiting developmental disorders with/without microcephaly.
Nervous System Diseases
CaM kinase II-alpha activity, levels and Ca/calmodulin dependent phosphorylation of substrate proteins in mice brain during fatal murine cerebral malaria.
Nervous System Diseases
Characterisation of the interaction between syndecan-2, neurofibromin and CASK: dependence of interaction on syndecan dimerization.
Neuralgia
Anti-hyperalgesic effect of CaMKII inhibitor is associated with downregulation of phosphorylated CREB in rat spinal cord.
Neuralgia
Ca(2+)/calmodulin-protein kinase IIalpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection.
Neuralgia
Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury.
Neuralgia
Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain.
Neuralgia
Inhibition of CaMKIV relieves streptozotocin-induced diabetic neuropathic pain through regulation of HMGB1.
Neuralgia
PSD95 gene specific siRNAs attenuate neuropathic pain through modulating neuron sensibility and postsynaptic CaMKII? phosphorylation.
Neuralgia
The cumulative analgesic effect of repeated electroacupuncture involves synaptic remodeling in the hippocampal CA3 region.
Neuralgia
[Effect of Electroacupuncture Intervention on CaMK II-CREB Pathway in Spinal Cord in Rats with Spared Nerve Injury].
Neuroblastoma
131I-MIBG targeting of neuroblastoma cells is acutely enhanced by KCl stimulation through the calcium/calmodulin-dependent kinase pathway.
Neuroblastoma
Ca(2+)-independent activity of Ca(2+)/calmodulin-dependent protein kinase II involved in stimulation of neurite outgrowth in neuroblastoma cells.
Neuroblastoma
Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells.
Neuroblastoma
Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis.
Neuroblastoma
CaMK-II modulation of GABA(A) receptors expressed in HEK293, NG108-15 and rat cerebellar granule neurons.
Neuroblastoma
Characterization of 5' flanking region of alpha isoform of rat Ca2+/calmodulin-dependent protein kinase II gene and neuronal cell type specific promoter activity.
Neuroblastoma
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
Neuroblastoma
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Neuroblastoma
Functional identification of the promoter for the gene encoding the alpha subunit of calcium/calmodulin-dependent protein kinase II.
Neuroblastoma
Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpiperazin e (KN-62).
Neuroblastoma
Interaction of Arc with CaM kinase II and stimulation of neurite extension by Arc in neuroblastoma cells expressing CaM kinase II.
Neuroblastoma
Investigation of the Ca(2+)-independent form of Ca(2+)/calmodulin-dependent protein kinase II in neurite outgrowth.
Neuroblastoma
Modulation by calcium/calmodulin-dependent protein kinase II of functional response of delta opioid receptor in neuroblastoma x glioma hybrid (NG108-15) cells.
Neuroblastoma
Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.
Neuroblastoma
Neurite outgrowth of neuroblastoma cells overexpressing alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II-effects of protein kinase inhibitors.
Neuroblastoma
Overexpression of Ca2+/calmodulin-dependent protein kinase II in Neuro2a and NG108-15 neuroblastoma cell lines promotes neurite outgrowth and growth cone motility.
Neuroblastoma
Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells.
Neuroblastoma
Retinoic acid stimulates alpha-CAMKII gene expression in PC12 cells at a distinct transcription initiation site.
Neuroblastoma
[Regulation of Ca2+/calmodulin-dependent protein kinase II in the cell systems in response to cellular stimuli]
Neurodegenerative Diseases
Calcium and neuronal cytoskeletal proteins: alterations with aging.
Neurodegenerative Diseases
Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Neurodegenerative Diseases
Effect of pH on the structure, function, and stability of human calcium/calmodulin-dependent protein kinase IV: combined spectroscopic and MD simulation studies.
Neurodegenerative Diseases
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
Neurodegenerative Diseases
High throughput screening, docking and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Neurodegenerative Diseases
Identification of Potential Inhibitors of Calcium/Calmodulin-Dependent Protein Kinase IV from Bioactive Phytoconstituents.
Neurodegenerative Diseases
Utilizing an Animal Model to Identify Brain Neurodegeneration-Related Biomarkers in Aging.
Neurologic Manifestations
Isoflurane pretreatment ameliorates postischemic neurologic dysfunction and preserves hippocampal Ca2+/calmodulin-dependent protein kinase in a canine cardiac arrest model.
Non-alcoholic Fatty Liver Disease
Intravenous sustained-release nifedipine ameliorates nonalcoholic fatty liver disease by restoring autophagic clearance.
Non-alcoholic Fatty Liver Disease
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Obesity
Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.
Obesity
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Obesity
Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects.
Obesity
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
Obesity
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Obesity
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
Obesity
Dietary restriction in the periconceptional period in normal-weight or obese ewes results in increased abundance of angiotensin-converting enzyme (ACE) and angiotensin type 1 receptor (AT1R) in the absence of changes in ACE or AT1R methylation in the adrenal of the offspring.
Obesity
Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse.
Obesity
Genome wide DNA differential methylation regions in colorectal cancer patients in relation to blood related family members, obese and non-obese controls - a preliminary report.
Obesity
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Obesity
Obesity and ischemic stroke modulate the methylation levels of KCNQ1 in white blood cells.
Obesity
Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.
Obesity
Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Obstetric Labor, Premature
Role of ERK1/2 in uterine contractility and preterm labor in rats.
Optic Atrophy
CASK mutations are frequent in males and cause X-linked nystagmus and variable XLMR phenotypes.
Osteoarthritis
Altered Wnt and NF-?B Signaling in Facet Joint Osteoarthritis: Insights from RNA Deep Sequencing.
Osteoarthritis
CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGF? and BMP through SMAD signaling.
Osteoarthritis
Systemic inhibition or global deletion of CaMKK2 protects against post-traumatic osteoarthritis.
Osteoarthritis
Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.
Osteoporosis
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
Osteosarcoma
alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression.
Osteosarcoma
Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma.
Ovarian Neoplasms
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
Ovarian Neoplasms
Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells.
Ovarian Neoplasms
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
Pancreatic Neoplasms
Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer.
Paralysis
Neuronal Ablation of Alpha/Beta Interferon (IFN-?/?) Signaling Exacerbates Central Nervous System Viral Dissemination and Impairs IFN-? Responsiveness in Microglia/Macrophages.
Paralysis
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
Paraplegia
Inactivation and subcellular redistribution of Ca2+/calmodulin-dependent protein kinase II following spinal cord ischemia.
Parathyroid Neoplasms
Calmodulin and calmodulin-dependent protein kinase II (CaMKII) inhibit hormone secretion in human parathyroid adenoma.
Parkinson Disease
A randomized controlled trial of levodopa in patients with Angelman syndrome.
Parkinson Disease
Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies.
Parkinson Disease
Improved detection of prostate cancer using a magneto-nanosensor assay for serum circulating autoantibodies.
Peritonitis
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.
Periventricular Nodular Heterotopia
AlphaCaMKII and NMDA-receptor subunit expression in epileptogenic cortex from human periventricular nodular heterotopia.
Pheochromocytoma
Activation of a calcium-calmodulin-dependent protein kinase I cascade in PC12 cells.
Pheochromocytoma
Hypoxia regulates the cAMP- and Ca2+/calmodulin signaling systems in PC12 cells.
Pheochromocytoma
Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells.
Pheochromocytoma
Phosphorylation of tyrosine hydroxylase on at least three sites in rat pheochromocytoma PC12 cells treated with 56 mM K+: determination of the sites on tyrosine hydroxylase phosphorylated by cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases.
Pheochromocytoma
Regulation of human tyrosine hydroxylase activity. Effects of cyclic AMP-dependent protein kinase, calmodulin-dependent protein kinase II and polyanion.
Pheochromocytoma
Retinoic acid stimulates alpha-CAMKII gene expression in PC12 cells at a distinct transcription initiation site.
Pick Disease of the Brain
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
Pituitary Neoplasms
Fibroblasts play a potential role in bone destruction via osteopontin related caldesmon expression and polymerization in human non-functioning pituitary adenomas.
Plant Diseases
Phylogeny of Plant Calcium and Calmodulin-Dependent Protein Kinases (CCaMKs) and Functional Analyses of Tomato CCaMK in Disease Resistance.
Prader-Willi Syndrome
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Prediabetic State
Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca(2+) release events in a rodent model of early stage diabetes: The arrhythmogenic substrate.
Presbyopia
Enhancing trabecular outflow by disrupting the actin cytoskeleton, increasing uveoscleral outflow with prostaglandins, and understanding the pathophysiology of presbyopia interrogating Mother Nature: asking why, asking how, recognizing the signs, following the trail.
Primary Myelofibrosis
CAMK2G is identified as a novel therapeutic target for myelofibrosis.
Prostatic Neoplasms
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
Prostatic Neoplasms
A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression.
Prostatic Neoplasms
Calcium/Calmodulin-Dependent Kinase II Plays an Important Role in Prostate Cancer Cell Survival.
Prostatic Neoplasms
Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells.
Prostatic Neoplasms
CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.
Prostatic Neoplasms
CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins.
Prostatic Neoplasms
CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.
Prostatic Neoplasms
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties.
Prostatic Neoplasms
Down-regulation of calcium/calmodulin-dependent protein kinase kinase 2 by androgen deprivation induces castration-resistant prostate cancer.
Prostatic Neoplasms
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.
Prostatic Neoplasms
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling.
Prostatic Neoplasms
Leupaxin stimulates adhesion and migration of prostate cancer cells through modulation of the phosphorylation status of the actin-binding protein caldesmon.
Prostatic Neoplasms
MicroRNA-224 and its target CAMKK2 synergistically influence tumor progression and patient prognosis in prostate cancer.
Prostatic Neoplasms
Nucleoporin 62 and Ca(2+) /calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells.
Prostatic Neoplasms
Organelle-derived acetyl-CoA promotes prostate cancer cell survival, migration, and metastasis via activation of calmodulin kinase II.
Prostatic Neoplasms
Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.
Prostatic Neoplasms
Targeting the 5'-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer.
Prostatic Neoplasms
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.
Proteinuria
CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
Proteinuria
Inhibition of calcium/calmodulin-dependent protein kinase type IV results in suppression of autoimmunity and organ pathology in lupus-prone mice.
Reperfusion Injury
Calcium-calmodulin-dependent protein kinase type 2 induces apoptosis of hepatocytes after liver transplantation.
Reperfusion Injury
Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy.
Reperfusion Injury
Role of calcium in inactivation of calcium/calmodulin dependent protein kinase II after cerebral ischemia.
Retinoblastoma
alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression.
Retinoblastoma
KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway.
Retinoblastoma
The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity.
Rhabdomyosarcoma
Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract.
Sarcoma
Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.
Sarcoma
Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue.
Sarcoma
h-Caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrial stromal sarcoma.
Sarcoma
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Sarcoma
Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases.
Sarcoma, Avian
A calmodulin-dependent protein kinase in Rous sarcoma virus-transformed rat cells and normal liver.
Sarcoma, Avian
Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation.
Sarcoma, Avian
Characterization of the properties of seven promoters in the motor cortex of rats and monkeys after lentiviral vector-mediated gene transfer.
Sarcoma, Avian
Morphological and biochemical analyses of contractile proteins (actin, myosin, caldesmon and tropomyosin) in normal and transformed cells.
Sarcoma, Endometrial Stromal
h-Caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrial stromal sarcoma.
Sarcoma, Endometrial Stromal
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Sarcoma, Synovial
Calponin and h-caldesmon expression in synovial sarcoma; the use of calponin in diagnosis.
Scrapie
Increased expression of CaM kinase II alpha in the brains of scrapie-infected mice.
Scrapie
The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models.
Seizures
Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.
Seizures
Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat.
Seizures
Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin.
Seizures
Attenuation of the seizure-induced expression of BDNF mRNA in adult rat brain by an inhibitor of calcium/calmodulin-dependent protein kinases.
Seizures
Bilirubin induces a calcium-dependent inhibition of multifunctional Ca2+/calmodulin-dependent kinase II activity in vitro.
Seizures
Brief seizure activity alters Ca2+/calmodulin dependent protein kinase II dephosphorylation and subcellular distribution in rat brain for several hours.
Seizures
Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy.
Seizures
Decreased expression of the alpha subunit of Ca2+/ calmodulin-dependent protein kinase type II mRNA in the adult rat CNS following recurrent limbic seizures.
Seizures
Dendritic targeting of mRNAs for plasticity genes in experimental models of temporal lobe epilepsy.
Seizures
Increased levels of mRNA for beta- but not alpha-subunit of calmodulin kinase II following kindled seizures.
Seizures
Leptin-regulated autophagy plays a role in long-term neurobehavioral injury after neonatal seizures and the regulation of zinc/cPLA2 and CaMK II signaling in cerebral cortex.
Seizures
Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.
Seizures
Loss of type II calcium/calmodulin-dependent kinase activity correlates with stages of development of electrographic seizures in status epilepticus in rat.
Seizures
Mechanism of the inhibitory effect of histamine on amygdaloid-kindled seizures in rats.
Seizures
miR-125a-5p alleviates dysfunction and inflammation of pentylenetetrazol-induced epilepsy through targeting calmodulin-dependent protein kinase IV (CAMK4).
Seizures
Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity.
Seizures
N-methyl-D-aspartate receptor dependent transcriptional regulation of two calcium/calmodulin-dependent protein kinase type II isoforms in rodent cerebral cortex.
Seizures
Thymoquinone and Vitamin C Attenuates Pentylenetetrazole-Induced Seizures Via Activation of GABAB1 Receptor in Adult Rats Cortex and Hippocampus.
Seizures
Zinc/CaMK II Associated-Mitophagy Signaling Contributed to Hippocampal Mossy Fiber Sprouting and Cognitive Deficits Following Neonatal Seizures and Its Regulation by Chronic Leptin Treatment.
Seizures
ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats.
Seizures
[Remote effects of early postnatal pituitary hormone melatonin injection on audiogenic seizures in Krushinsky-Molodkina rats]
Sepsis
Calcium Supplementation During Sepsis Exacerbates Organ Failure and Mortality via Calcium/Calmodulin-Dependent Protein Kinase Kinase Signaling.
Sepsis
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.
Sepsis
Calcium/calmodulin-dependent protein kinase (CaMK) I{alpha} mediates the macrophage inflammatory response to sepsis.
Sepsis
Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis.
Shock, Septic
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
Sick Sinus Syndrome
Insulin sensitization causes accelerated sinus nodal dysfunction through autophagic dysregulation in hypertensive mice.
Sick Sinus Syndrome
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Situs Inversus
Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos.
Skin Diseases
Inhibition of calcium/calmodulin-dependent protein kinase type IV results in suppression of autoimmunity and organ pathology in lupus-prone mice.
Small Cell Lung Carcinoma
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.
Small Cell Lung Carcinoma
CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma.
Small Cell Lung Carcinoma
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Small Cell Lung Carcinoma
Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) .
Smooth Muscle Tumor
h-Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors.
Smooth Muscle Tumor
High molecular weight caldesmon expression in ovarian adult granulosa cell tumor and fibrothecoma.
Smooth Muscle Tumor
Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer.
Spinal Cord Injuries
Activation of Ca2+/calmodulin-dependent protein kinase II alpha in the spinal cords of rats with clip compression injury.
Spinal Cord Injuries
Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury.
Spinal Cord Injuries
Phosphorylation of neuronal nitric oxide synthase at Ser847 in the nucleus intermediolateralis after spinal cord injury in mice.
Spinal Cord Ischemia
Effect of cerebral ischemia on calcium/calmodulin-dependent protein kinase II activity and phosphorylation.
Spinal Cord Ischemia
Spinal cord ischemia reduces calcium/calmodulin-dependent protein kinase activity.
Squamous Cell Carcinoma of Head and Neck
Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.
ST Elevation Myocardial Infarction
Calcium/Calmodulin-Dependent Protein Kinase II Delta Inhibition and Ventricular Remodeling After Myocardial Infarction: A Randomized Clinical Trial.
Starvation
CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux.
Starvation
Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling.
Status Epilepticus
Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat.
Status Epilepticus
Loss of type II calcium/calmodulin-dependent kinase activity correlates with stages of development of electrographic seizures in status epilepticus in rat.
Status Epilepticus
Microglial calcium signaling is attuned to neuronal activity in awake mice.
Status Epilepticus
Modulation of CaM kinase II activity is coincident with induction of status epilepticus in the rat pilocarpine model.
Status Epilepticus
Status epilepticus results in an N-methyl-D-aspartate receptor-dependent inhibition of Ca2+/calmodulin-dependent kinase II activity in the rat.
Stomach Neoplasms
A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.
Stomach Neoplasms
AMPK? phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation.
Stomach Neoplasms
Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma.
Stomach Neoplasms
Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein.
Stomach Neoplasms
Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer.
Stroke
Bilirubin induces a calcium-dependent inhibition of multifunctional Ca2+/calmodulin-dependent kinase II activity in vitro.
Stroke
Calcium/calmodulin-dependent protein kinase kinase ? is neuroprotective in stroke in aged mice.
Stroke
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology.
Stroke
Genetic deletion of calcium/calmodulin-dependent protein kinase kinase ? (CaMKK ?) or CaMK IV exacerbates stroke outcomes in ovariectomized (OVXed) female mice.
Stroke
Global forebrain ischemia results in decreased immunoreactivity of calcium/calmodulin-dependent protein kinase II.
Stroke
Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke.
Stroke
Obesity and ischemic stroke modulate the methylation levels of KCNQ1 in white blood cells.
Supranuclear Palsy, Progressive
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
Sweat Gland Neoplasms
CD34-positive stromal cells and alpha-smooth muscle actin-positive stromal cells in the tumor capsule of skin sweat gland neoplasms.
Syncope
Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor: A case report and review of the literature.
Synucleinopathies
Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein.
Tachycardia
The role of stretch, tachycardia and sodium-calcium exchanger in induction of early cardiac remodelling.
Tachycardia, Ventricular
Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.
Tachycardia, Ventricular
Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?
Tauopathies
Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies.
Tetanus
Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.
Tetanus
Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons.
Tetanus
[Role of phospho-calcium/ calmodulin-dependent protein kinase II in the induction and maintenance of long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn of the rat]
Thyroid Neoplasms
Calcium/Calmodulin-Dependent Protein Kinase II and Its Endogenous Inhibitor ? in Medullary Thyroid Cancer.
Tuberculosis
Mycobacterium tuberculosis phagosomes exhibit altered calmodulin-dependent signal transduction: contribution to inhibition of phagosome-lysosome fusion and intracellular survival in human macrophages.
Tuberculosis
The role of CAMKK2 polymorphisms in HIV-associated sensory neuropathy in South Africans.
Tuberous Sclerosis
AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor.
Tuberous Sclerosis
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Urinary Bladder Neck Obstruction
Effect of long-term partial bladder outlet obstruction on caldesmon isoforms and their correlation with contractile function.
Urinary Bladder Neck Obstruction
Smooth muscle hypertrophy following partial bladder outlet obstruction is associated with overexpression of non-muscle caldesmon.
Urinary Bladder Neck Obstruction
[Experimental study of the expression of the bladder wall proteins in bladder outlet obstruction in the rabbit]
Urinary Bladder Neoplasms
Overexpression of caldesmon is associated with tumor progression in patients with primary non-muscle-invasive bladder cancer.
Uterine Cervical Neoplasms
Systematic profiling of alternative splicing signature reveals prognostic predictor for cervical cancer.
Uterine Prolapse
Differential expression of smooth muscle regulatory proteins in the uterosacral ligaments of women with uterine prolapse.
Vascular System Injuries
CaMKII-delta isoform regulation of neointima formation after vascular injury.
Ventricular Dysfunction
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Ventricular Fibrillation
Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart.
Viremia
Polymorphisms in CAMKK2 associate with susceptibility to sensory neuropathy in HIV patients treated without stavudine.
Virus Diseases
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.
Virus Diseases
Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brain.
Whooping Cough
Agonist-specific alterations in receptor-phospholipase coupling following inactivation of Gi2alpha gene.
Whooping Cough
N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.
Wilms Tumor
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). KCC2B_HUMAN
666
0
72678
Swiss-Prot
other Location (Reliability: 1)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
at least five alternative splicing variants of beta CaMKII
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q13554), Homo sapiens (Q9UQM7), Metarhizium anisopliae (O14408), Mus musculus (Q923T9)
brenda
Rochlitz, H.; Voigt, A.; Lankat-Buttgereit, B.; Goke, B.; Heimberg, H.; Nauck, M.A.; Schiemann, U.; Schatz, H.; Pfeiffer, A.F.
Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells
Diabetologia
43
465-473
2000
Homo sapiens (Q13554), Homo sapiens
brenda
Tombes, R.M.; Krystal, G.W.
Identification of novel human tumor cell-specific CaMK-II variants
Biochim. Biophys. Acta
1355
281-292
1997
Homo sapiens (Q13554), Homo sapiens (Q13557)
brenda
Wang, P.; Wu, Y.L.; Zhou, T.H.; Sun, Y.; Pei, G.
Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities
FEBS Lett.
475
107-110
2000
Homo sapiens (Q13554)
brenda
Huynh, Q.K.; Pagratis, N.
Kinetic mechanisms of Ca++/calmodulin dependent protein kinases
Arch. Biochem. Biophys.
506
130-136
2011
Homo sapiens (Q13554), Homo sapiens (Q13555), Homo sapiens (Q13557), Homo sapiens (Q9UQM7)
brenda
EXTERNAL LINKS (specific for EC-Number 2.7.11.17)
Transporter Classification Database (TCDB): 8.A.104.1.12, 8.A.24.1.11
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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