Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.11.14 - rhodopsin kinase and Organism(s) Danio rerio and UniProt Accession Q1XHL7

for references in articles please use BRENDA:EC2.7.11.14
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Danio rerio
UNIPROT: Q1XHL7
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
rk, rhodopsin kinase, g protein-coupled receptor kinase, g-protein receptor kinase, g-protein coupled receptor kinase, g protein-coupled receptor kinase 1, g-protein coupled receptor kinase 1, gprk1, g-protein-coupled receptor kinase 1, g-protein receptor kinase-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G protein-coupled receptor kinase
-
cone-specific kinase GRK7
-
G protein-coupled receptor kinase
-
G protein-coupled receptor kinase 1
-
-
-
-
G-protein coupled protein kinase 7a
-
G-protein coupled protein kinase 7b
-
GPCR kinase 1
-
-
-
-
kinase (phosphorylating), opsin
-
-
-
-
kinase (phosphorylating), rhodopsin
-
-
-
-
opsin kinase
-
-
-
-
RK
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:rhodopsin phosphotransferase
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
54004-64-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + opsin
ADP + phosphoopsin
show the reaction diagram
ATP + cone opsin
ADP + phosphorylated cone opsin
show the reaction diagram
light-dependent phosphorylation
-
-
?
ATP + opsin
ADP + phosphoopsin
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + opsin
ADP + phosphoopsin
show the reaction diagram
the enzyme is involved in the opsin deactivation process, GRK subtypes play a role in phosphorylating non-visual opsins in the particular extraretinal tissues
-
-
?
ATP + cone opsin
ADP + phosphorylated cone opsin
show the reaction diagram
light-dependent phosphorylation
-
-
?
ATP + opsin
ADP + phosphoopsin
show the reaction diagram
the enzyme is involved in the opsin deactivation process, GRK subtypes play a role in phosphorylating non-visual opsins in the particular extraretinal tissues
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isozyme GRK7-2; gene grk7b, isozyme GRK 7–2
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GRK7-2, almost exclusively in the brain
Manually annotated by BRENDA team
GRK1B and GRK7-2 are the dominant subtypes
Manually annotated by BRENDA team
rods and cones
Manually annotated by BRENDA team
GRK1B and GRK7-2 are the dominant subtypes
Manually annotated by BRENDA team
rods and cones
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GRK7B_DANRE
548
0
62609
Swiss-Prot
other Location (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
isozyme GRK7–2, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293S cells
gene grk7a, DNA and amino acid sequence determination and analysis
gene grk7b, DNA and amino acid sequence determination and analysis
isozyme GRK1 1A, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression of GRK proteins in HEK-293S cells
isozyme GRK1B, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression of GRK proteins in HEK-293S cells
isozyme GRK7 7–1, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293S cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rinner, O.; Makhankov, Y.V.; Biehlmaier, O.; Neuhauss, S.C.F.
Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptation
Neuron
47
231-242
2005
Danio rerio, Danio rerio (Q49HM8), Danio rerio (Q49HM9)
Manually annotated by BRENDA team
Wada, Y.; Sugiyama, J.; Okano, T.; Fukada, Y.
GRK1 and GRK7: unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones
J. Neurochem.
98
824-837
2006
Danio rerio (Q1XHL7), Danio rerio (Q1XHM0), Danio rerio (Q49HM9), Danio rerio (Q49HN0), Danio rerio
Manually annotated by BRENDA team