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Information on EC 2.7.11.13 - protein kinase C and Organism(s) Oryctolagus cuniculus and UniProt Accession P05772

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IUBMB Comments
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
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This record set is specific for:
Oryctolagus cuniculus
UNIPROT: P05772
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Word Map
The taxonomic range for the selected organisms is: Oryctolagus cuniculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase c, pkcalpha, pkc-alpha, pkc alpha, pkcepsilon, pkc-delta, pkczeta, pkc-epsilon, pkc delta, pkc-zeta, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
protein kinase C, beta type
-
Calcium-dependent protein kinase C
-
-
-
-
epsilonPKC
-
-
-
-
protein kinase C
-
-
-
-
protein kinase C, alpha type
-
protein kinase C, epsilon type
-
protein kinase C, gamma type
-
protein kinase C, zeta type
-
protein kinase-C
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (diacylglycerol-dependent)
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
CAS REGISTRY NUMBER
COMMENTARY hide
141436-78-4
calcium-dependent protein kinase C
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + store-operated channel
ADP + phosphorylated store-operated channel
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
chelerythrine
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-oleoyl-2-acetyl-sn-glycerol
-
0.01 mM
phorbol 12,13-dibutyrate
-
0.001 mM
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KPCB_RABIT
671
0
76828
Swiss-Prot
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hao, C.M.; Breyer, R.M.; Davis, L.S.; Breyer, M.D.
Intrarenal distribution of rabbit PKC zeta
Kidney Int.
51
1831-1837
1997
Oryctolagus cuniculus (O19111), Oryctolagus cuniculus
Manually annotated by BRENDA team
Nishizuka, Y.
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
Nature
334
661-665
1988
Bos taurus (P04409), Bos taurus (P05126), Rattus norvegicus (P05696), Oryctolagus cuniculus (P10102)
Manually annotated by BRENDA team
Ohno, S.; Kawasaki, H.; Imajoh, S.; Suzuki, K.; Inagaki, M.; Yokokura, H.; Sakoh, T.; Hidaka, H.
Tissue-specific expression of three distinct types of rabbit protein kinase C
Nature
325
161-166
1987
Oryctolagus cuniculus (P05772), Oryctolagus cuniculus (P10102), Oryctolagus cuniculus
Manually annotated by BRENDA team
Ohno, S.; Kawasaki, H.; Konno, Y.; Inagaki, M.; Hidaka, H.; Suzuki, K.
A fourth type of rabbit protein kinase C
Biochemistry
27
2083-2087
1988
Oryctolagus cuniculus (P10829), Oryctolagus cuniculus
Manually annotated by BRENDA team
Ohno, S.; Akita, Y.; Konno, Y.; Imajoh, S.; Suzuki, K.
A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family
Cell
53
731-741
1988
Oryctolagus cuniculus (P10830), Oryctolagus cuniculus
Manually annotated by BRENDA team
Saleh, S.N.; Albert, A.P.; Peppiatt-Wildman, C.M.; Large, W.A.
Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes
J. Physiol.
586
2463-2476
2008
Oryctolagus cuniculus
Manually annotated by BRENDA team