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Acquired Immunodeficiency Syndrome
Deletion of pknG Abates Reactivation of Latent Mycobacterium tuberculosis in Mice.
Adenomatous Polyposis Coli
Killing me softly - suicidal erythrocyte death.
Adenomatous Polyposis Coli
Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes.
Adenomatous Polyposis Coli
Physiology and pathophysiology of eryptosis.
Alzheimer Disease
An algorithm for direct causal learning of influences on patient outcomes.
Alzheimer Disease
Induction of antioxidative and antiapoptotic thioredoxin supports neuroprotective hypothesis of estrogen.
Alzheimer Disease
Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition.
Anemia
Killing me softly - suicidal erythrocyte death.
Anemia
Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes.
Anemia
Physiology and pathophysiology of eryptosis.
Anemia, Sickle Cell
Killing me softly - suicidal erythrocyte death.
Anemia, Sickle Cell
Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes.
Anemia, Sickle Cell
Physiology and pathophysiology of eryptosis.
Aneurysm, Dissecting
Aortic progression and reintervention in patients with pathogenic variants after a thoracic aortic dissection.
Aneurysm, Dissecting
Exome sequencing reveals a de novo PRKG1 mutation in a sporadic patient with aortic dissection.
Aneurysm, Dissecting
Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections.
Aneurysm, Dissecting
The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G>A (p.Arg177Gln).
Aortic Aneurysm, Thoracic
A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP.
Aortic Aneurysm, Thoracic
Association of modifiers and other genetic factors explain Marfan syndrome clinical variability.
Aortic Aneurysm, Thoracic
Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections.
Aortic Aneurysm, Thoracic
Testing patterns for genetically triggered aortic and arterial aneurysms and dissections at an academic center.
Aortic Aneurysm, Thoracic
The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G>A (p.Arg177Gln).
Aortic Diseases
A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP.
Aortic Diseases
Exome sequencing reveals a de novo PRKG1 mutation in a sporadic patient with aortic dissection.
Aortic Diseases
PRKG1 and genetic diagnosis of early-onset thoracic aortic disease.
Aortic Diseases
Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections.
Asthma
Single Nucleotide Polymorphisms (SNPs) in PRKG1 & SPATA13-AS1 are associated with bronchodilator response: a pilot study during acute asthma exacerbations in African American children.
Atherosclerosis
Regulation of gene expression by cyclic GMP.
Atherosclerosis
Transplant atherosclerosis: role of phenotypic modulation of vascular smooth muscle by nitric oxide.
Bone Neoplasms
cGMP and cGMP-Dependent Protein Kinase I Pathway in Dorsal Root Ganglia Contributes to Bone Cancer Pain in Rats.
Bradycardia
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.
Brain Injuries
The cyclic GMP-protein kinase G pathway regulates cytoskeleton dynamics and motility in astrocytes.
Brain Neoplasms
Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines.
Breast Neoplasms
cGMP-dependent Protein Kinase I? Regulates Breast Cancer Cell Migration and Invasion via a Novel Interaction with the Actin/Myosin-associated Protein Caldesmon.
Breast Neoplasms
Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines.
Breast Neoplasms
Expression of cGMP-dependent protein kinase, PKGI?, PKGI?, and PKGII in malignant and benign breast tumors.
Breast Neoplasms
Induction of apoptosis by type I? protein kinase G in the human breast cancer cell lines MCF-7 and MDA-MB-468.
Breast Neoplasms
Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.
Breast Neoplasms
The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression.
Breast Neoplasms
Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells.
Carcinogenesis
Induction of antioxidative and antiapoptotic thioredoxin supports neuroprotective hypothesis of estrogen.
Carcinoma
An anti-tumor role for cGMP-dependent protein kinase.
Carcinoma
Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.
Carcinoma
Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator.
Carcinoma, Ehrlich Tumor
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Carcinoma, Hepatocellular
eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells.
Cardiomegaly
Alterations in activities of cyclic nucleotide systems and in beta-adrenergic receptor-mediated activation of cyclic AMP-dependent protein kinase during progression and regression of isoproterenol-induced cardiac hypertrophy.
Cardiomegaly
Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction.
Cardiomegaly
B-type natriuretic peptide attenuates cardiac hypertrophy via TGF-beta1/smad7 pathway in vivo and in vitro.
Cardiomegaly
Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes.
Cardiomegaly
Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways.
Cardiomegaly
Murine cardiac growth, TRPC channels, and cGMP kinase I.
Cardiomegaly
Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes.
Cardiomegaly
Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway.
Cardiomegaly
Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition.
Cardiomegaly
Regression of pathological cardiac hypertrophy: Signaling pathways and therapeutic targets.
Cardiomegaly
Regulation of gene expression by cyclic GMP.
Cardiomegaly
Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms.
Cardiomegaly
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis.
Cardiomegaly
Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T.
Cardiomegaly
Sildenafil Reduces Neointimal Hyperplasia after Angioplasty and Inhibits Platelet Aggregation via Activation of cGMP-dependent Protein Kinase.
Cardiomegaly
The Emperor's New Clothes: PDE5 and the Heart.
Cardiomegaly
Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond.
Cardiomyopathies
Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy.
Cardiomyopathy, Dilated
Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I.
Cardiovascular Diseases
Adenosine analogue-oligo-arginine conjugates (ARCs) serve as high-affinity inhibitors and fluorescence probes of type I cGMP-dependent protein kinase (PKGIalpha).
Cardiovascular Diseases
High blood pressure arising from a defect in vascular function.
Cardiovascular Diseases
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Cerebral Infarction
[Effects of electroacupuncture "Shuigou" on expression of soluble guanylate cyclase(sGC) and protein kinase G (PKG)in vascular smooth muscle of cerebral artery in rats with cerebral infarction].
Cerebrovascular Disorders
Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia.
cgmp-dependent protein kinase deficiency
cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness.
cgmp-dependent protein kinase deficiency
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.
cgmp-dependent protein kinase deficiency
Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation.
cgmp-dependent protein kinase deficiency
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Cholangiocarcinoma
Guanylin regulates chloride secretion in the human gallbladder via the bile fluid.
Cholera
Inhibition by the protein kinase inhibitors, isoquinolinesulfonamides, of fluid accumulation induced by Escherichia coli heat-stable enterotoxin, 8-bromo-cGMP and 8-bromo-cAMP in suckling mice.
Cholera
Molecular modulation of inward and outward apical transporters of L-dopa in LLC-PK(1) cells.
Cholera
Regulation of apical transporter of L-DOPA in human intestinal Caco-2 cells.
Cholera
Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP.
Chondrosarcoma
Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells.
Coccidiosis
Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity.
Coccidiosis
Molecular characterization of a coccidian parasite cGMP dependent protein kinase.
Coccidiosis
Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.
Colonic Neoplasms
Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells.
Colonic Neoplasms
Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.
Colonic Neoplasms
Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.
Colonic Neoplasms
cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.
Colonic Neoplasms
Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells.
Colonic Neoplasms
Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer.
Colonic Neoplasms
New dimeric cGMP analogues reduce proliferation in three colon cancer cell lines.
Colonic Neoplasms
PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.
Colonic Neoplasms
Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation.
Colonic Neoplasms
Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1.
Colonic Neoplasms
Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.
Colonic Neoplasms
Type II cGMP?dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells.
Color Vision Defects
The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia.
Colorectal Neoplasms
Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21.
Colorectal Neoplasms
Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer.
Contracture
Role of endothelin-A receptors in ischemic contracture and reperfusion injury.
Cystic Fibrosis
cGMP stimulation of cystic fibrosis transmembrane conductance regulator Cl- channels co-expressed with cGMP-dependent protein kinase type II but not type Ibeta.
Cystic Fibrosis
Cl- transport in an immortalized human epithelial cell line (NCM460) derived from the normal transverse colon.
Cystic Fibrosis
Clara cell impact in air-side activation of CFTR in small pulmonary airways.
Cystic Fibrosis
Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells.
Cystic Fibrosis
Guanylin and related peptides.
Cystic Fibrosis
Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.
Cystic Fibrosis
Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II.
Cystic Fibrosis
Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation.
Cystic Fibrosis
Microvillus inclusion disease: a genetic defect affecting apical membrane protein traffic in intestinal epithelium.
Cystic Fibrosis
N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II.
Cystic Fibrosis
Ontogeny of guanylin-immunoreactive cells in rat salivary glands.
Cystic Fibrosis
Rising behind NO: cGMP-dependent protein kinases.
Cystic Fibrosis
The alpha2beta1 isoform of guanylyl cyclase mediates plasma membrane localized nitric oxide signalling.
Cystic Fibrosis
The amino-terminal cyclic nucleotide binding site of the type II cGMP-dependent protein kinase is essential for full cyclic nucleotide-dependent activation.
Dehydration
Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression.
Demyelinating Diseases
Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease.
Dengue
West Nile virus methyltransferase domain interacts with protein kinase G.
Diabetes Mellitus
A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation.
Diabetes Mellitus
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus
Expression and distribution of cyclic GMP-dependent protein kinase-1 isoforms in human penile erectile tissue.
Diabetes Mellitus
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Diabetes Mellitus
Pharmic Activation of PKG2 Alleviates Diabetes-Induced Osteoblast Dysfunction by Suppressing PLC?1-Ca2+-Mediated Endoplasmic Reticulum Stress.
Diabetes Mellitus, Type 1
Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes.
Diabetes Mellitus, Type 2
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus, Type 2
Pharmic Activation of PKG2 Alleviates Diabetes-Induced Osteoblast Dysfunction by Suppressing PLC?1-Ca2+-Mediated Endoplasmic Reticulum Stress.
Dwarfism
A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle.
Dwarfism
Current insights into the molecular genetic basis of dwarfism in livestock.
Dwarfism
Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification.
Dwarfism
Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.
Dwarfism
Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytes.
Dwarfism
Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2.
Dwarfism
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.
Dwarfism
Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2.
Dwarfism
[Natriuretic peptides as novel growth factor of growth plate cartilage]
Endotoxemia
In the rostral ventrolateral medulla, the 70-kDa heat shock protein (HSP70), but not HSP90, confers neuroprotection against fatal endotoxemia via augmentation of nitric-oxide synthase I (NOS I)/protein kinase G signaling pathway and inhibition of NOS II/peroxynitrite cascade.
Epilepsy
Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Epilepsy, Temporal Lobe
Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Erectile Dysfunction
Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha.
Erectile Dysfunction
Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice.
Erectile Dysfunction
Expression and distribution of cyclic GMP-dependent protein kinase-1 isoforms in human penile erectile tissue.
Erectile Dysfunction
Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction.
Erectile Dysfunction
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Erectile Dysfunction
Preserved fertility despite erectile dysfunction in mice lacking the nitric oxide receptor.
Glioblastoma
CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.
Glioblastoma
Multiple forms of protein kinase from normal human brain and glioblastoma.
Glioblastoma
Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior. Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells.
Glioma
CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.
Glioma
Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines.
Glioma
Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.
Glioma
Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior. Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells.
Glioma
Type II cGMP?dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells.
Glioma
Type II, but not type I, cGMP-dependent protein kinase reverses bFGF-induced proliferation and migration of U251 human glioma cells.
Glucose Intolerance
Overexpression of Constitutively Active PKG-I Protects Female, But Not Male Mice From Diet-Induced Obesity.
Gout
Common variants of cGKII/PRKG2 are not associated with gout susceptibility.
Gout
Cyclic GMP-dependent protein kinase II is necessary for macrophage M1 polarization and phagocytosis via toll-like receptor 2.
Gout
Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.
Gout
Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China.
Gout
The cyclic GMP-dependent protein kinase II gene associates with gout disease identified by genome-wide analysis and case-control study.
Granuloma
"It Takes Two to Tango": Role of Neglected Macrophage Manipulators Coronin 1 and Protein Kinase G in Mycobacterial Pathogenesis.
Heart Diseases
Left Ventricular Radial Function Associated With Genetic Variation in the cGMP-Dependent Protein Kinase.
Heart Diseases
Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials.
Heart Diseases
Targeting Protein Kinase G to Treat Cardiac Proteotoxicity.
Heart Failure
A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation.
Heart Failure
cGMP Signaling and Modulation in Heart Failure.
Heart Failure
Chronic Sildenafil Therapy in the ZSF1 Obese Rat Model of Metabolic Syndrome and Heart Failure With Preserved Ejection Fraction.
Heart Failure
Low myocardial protein kinase g activity in heart failure with preserved ejection fraction.
Heart Failure
Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-I? Substrate.
Heart Failure
Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G I? Oxidation.
Heart Failure
Phosphodiesterase type 5: expanding roles in cardiovascular regulation.
Heart Failure
Protein kinase G I and heart failure: Shifting focus from vascular unloading to direct myocardial antiremodeling effects.
Heart Failure
Targeting Protein Kinase G to Treat Cardiac Proteotoxicity.
Heart Failure
The Emperor's New Clothes: PDE5 and the Heart.
Hepatic Encephalopathy
Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations.
Herpes Zoster
cGMP-dependent protein kinase II and aldosterone secretion.
Herpes Zoster
cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene.
Huntington Disease
Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease.
Hyperalgesia
Activation of cGMP-dependent protein kinase Ialpha is required for N-methyl-D-aspartate- or nitric oxide-produced spinal thermal hyperalgesia.
Hyperalgesia
cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression.
Hyperalgesia
Cofilin phosphorylation is involved in nitric oxide/cGMP-mediated nociception.
Hyperalgesia
Dissociation of dorsal root ganglion neurons induces hyperexcitability that is maintained by increased responsiveness to cAMP and cGMP.
Hyperalgesia
Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats.
Hyperalgesia
Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord.
Hyperalgesia
Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signalling in spinal cord in mice.
Hyperalgesia
Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons.
Hyperalgesia
Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia.
Hyperalgesia
Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain.
Hyperalgesia
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Hyperalgesia
Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy.
Hyperalgesia
Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat.
Hyperalgesia
The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin.
Hyperglycemia
Cinaciguat in combination with insulin induces a favorable effect on implant osseointegration in type 2 diabetic rats.
Hyperglycemia
Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia.
Hyperglycemia
Hyperglycemia down-regulates cGMP-dependent protein kinase I expression in first trimester cytotrophoblast cells.
Hyperlipidemias
Lei-gong-gen formula granule attenuates hyperlipidemia in rats via cGMP-PKG signaling pathway.
Hypersensitivity
Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain.
Hypersensitivity
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Hypersensitivity
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Hypersensitivity
SNO-ing at the Nociceptive Synapse?
Hypertension
A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation.
Hypertension
A Role of Intestine in Hypertension: Mechanism of Suppression of Intestinal Na-H Exchanger Isoform-3 in Spontaneously Hypertensive Rats.
Hypertension
Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle.
Hypertension
Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction.
Hypertension
Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization?
Hypertension
Endothelial dysfunction and systemic hypertension by selective cGMP-dependent protein kinase I inhibition using novel cell-penetrating peptide delivered in vivo.
Hypertension
Genetic susceptibility to salt-sensitive hypertension in a Han Chinese population: a validation study of candidate genes.
Hypertension
Genetically, Dietary Sodium Intake Is Causally Associated with Salt-Sensitive Hypertension Risk in a Community-Based Cohort Study: a Mendelian Randomization Approach.
Hypertension
High blood pressure arising from a defect in vascular function.
Hypertension
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Hypertension
Nitric oxide regulates c-fos expression in nucleus tractus solitarii induced by baroreceptor activation via cGMP-dependent protein kinase and cAMP response element-binding protein phosphorylation.
Hypertension
Rare Causes of Arterial Hypertension and Thoracic Aortic Aneurysms-A Case-Based Review.
Hypertension
Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4.
Hypertension
Regulation of gene expression by cyclic GMP.
Hypertension
Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension.
Hypertension
The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G>A (p.Arg177Gln).
Hypertension, Pulmonary
Identification of nitrated tyrosine residues of protein kinase G-I? by mass spectrometry.
Hypertension, Pulmonary
Protein kinase G dysfunction is an important factor in induced pulmonary hypertension in mice.
Hypertension, Pulmonary
Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation.
Hypertension, Renovascular
Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization?
Hyperthyroidism
Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization?
Hypertrophy, Left Ventricular
Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization?
Hypertrophy, Right Ventricular
Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery.
Hypertrophy, Right Ventricular
The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.
Hypogonadism
Testosterone-induced modulation of nitric oxide-cGMP signaling pathway and androgenesis in the rat Leydig cells.
Hypotension
Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
Hypotension
Cyclic GMP-dependent and cyclic AMP-dependent protein kinases, protein kinase modulators and phosphodiesterases in arteries and veins of dogs. Distribution and effects of arteriovenous fistula and arterial occlusion.
Infections
"It Takes Two to Tango": Role of Neglected Macrophage Manipulators Coronin 1 and Protein Kinase G in Mycobacterial Pathogenesis.
Infections
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
Infections
cGMP stimulation of cystic fibrosis transmembrane conductance regulator Cl- channels co-expressed with cGMP-dependent protein kinase type II but not type Ibeta.
Infections
cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene.
Infections
Cyclic Guanosine Monophosphate (cGMP)-Dependent Protein Kinase II Blocks Epidermal Growth Factor (EGF)/Epidermal Growth Factor Receptor (EGFR)-Induced Biological Effects on Osteosarcoma Cells.
Infections
HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model.
Infections
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.
Infections
Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs.
Infections
M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival.
Infections
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity.
Infections
Protein kinase of bacteriophage T7. 1. Purification.
Infections
Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells.
Infections
Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823.
Insulin Resistance
cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation.
Intellectual Disability
Further defining the critical genes for the 4q21 microdeletion disorder.
Ischemic Stroke
cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice.
Leukemia
Acute Mast Cell Leukemia Associated with t(4;5)(q21;q33).
Leukemia, Mast-Cell
Acute Mast Cell Leukemia Associated with t(4;5)(q21;q33).
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia.
Leukemia, Myeloid, Acute
Marked response to imatinib mesylate in a patient with platelet-derived growth factor receptor beta-associated acute myeloid leukemia.
Loeys-Dietz Syndrome
Testing patterns for genetically triggered aortic and arterial aneurysms and dissections at an academic center.
Lordosis
Inhibition of lordosis behavior by intrahypothalamic infusion of a protein kinase G antagonist.
Lordosis
Regulation of lordosis by cyclic 3',5'-guanosine monophosphate, progesterone, and its 5alpha-reduced metabolites involves mitogen-activated protein kinase.
Lordosis
The nitric oxide pathway participates in estrous behavior induced by progesterone and some of its ring A-reduced metabolites.
Lordosis
The nitric oxide pathway participates in lordosis behavior induced by central administration of leptin.
Lung Injury
Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G.
Lymphoma
Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line.
Lymphoma
Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.
Lymphoma, B-Cell
Cardiac uses of phosphodiesterase-5 inhibitors.
Lymphoma, B-Cell
No donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling.
Malaria
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG.
Malaria
cGMP Binding Domain D Mediates a Unique Activation Mechanism in Plasmodium falciparum PKG.
Malaria
Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.
Malaria
Dynamical Basis of Allosteric Activation for the Plasmodium falciparum Protein Kinase G.
Malaria
Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase.
Malaria
Keep a lid on it: A troika in kinase allostery.
Malaria
Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress.
Malaria
Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase.
Malaria
Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites.
Malaria
Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion.
Malaria
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Malaria
Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs.
Malaria
The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony.
Malnutrition
Effect of restricted food intake on production, catabolism, and effects of IGF-I and cyclic nucleotides in cultured ovarian tissue of domestic nutria (Myocastor coypus).
Marfan Syndrome
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.
Melanoma
Activation of cGMP-Dependent Protein Kinase Restricts Melanoma Growth and Invasion by Interfering with the EGF/EGFR Pathway.
Melanoma
Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth.
Memory Disorders
Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice.
Metabolic Syndrome
Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase.
Metabolic Syndrome
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Multiple Sclerosis
Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition.
Myeloproliferative Disorders
Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia.
Myeloproliferative Disorders
Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders.
Neoplasm Metastasis
Protein Kinases Type II (PKG II) Combined with L-Arginine Significantly Ameliorated Xenograft Tumor Development: Is L-Arginine a Potential Alternative in PKG II Activation?
Neoplasm Metastasis
The constitutively active PKG II mutant effectively inhibits gastric cancer development
Neoplasms
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and ?-catenin transcriptional activity.
Neoplasms
A Xanthine-Based Epithelium-Dependent Airway Relaxant KMUP-3 (7-[2-[4-(4-Nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) Increases Respiratory Performance and Protects against Tumor Necrosis Factor-{alpha}-Induced Tracheal Contraction, Involving Nitric Oxide Release and Expression of cGMP and Protein Kinase G.
Neoplasms
Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells.
Neoplasms
Active PKG II inhibited the growth and migration of ovarian cancer cells through blocking Raf/MEK and PI3K/Akt signaling pathways.
Neoplasms
An anti-tumor role for cGMP-dependent protein kinase.
Neoplasms
Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomis rotata (Benth.) Kudo in rats with spared nerve injury.
Neoplasms
Anti-tumor properties of the cGMP/protein kinase G inhibitor DT3 in pancreatic adenocarcinoma.
Neoplasms
Atrial natriuretic peptide inhibits the phosphoinositide hydrolysis in murine Leydig tumor cells.
Neoplasms
Basal, cAMP- and cGMP-dependent protein kinases in human brain tumors.
Neoplasms
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Neoplasms
Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.
Neoplasms
cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2.
Neoplasms
Characterization of protein tyrosine kinase activity in murine Leydig tumor cells.
Neoplasms
CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.
Neoplasms
Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines.
Neoplasms
Cyclic GMP specifically suppresses Type-Ialpha cGMP-dependent protein kinase expression by ubiquitination.
Neoplasms
Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.
Neoplasms
Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines.
Neoplasms
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Neoplasms
Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
Neoplasms
Endogenous cGMP-dependent protein kinase reverses EGF-induced MAPK/ERK signal transduction through phosphorylation of VASP at Ser239.
Neoplasms
Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis.
Neoplasms
Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice.
Neoplasms
High HSPA8 expression predicts adverse outcomes of acute myeloid leukemia.
Neoplasms
Induction of apoptosis by type I? protein kinase G in the human breast cancer cell lines MCF-7 and MDA-MB-468.
Neoplasms
Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G.
Neoplasms
Mini Review: Pathophysiology of Erectile Dysfunction.
Neoplasms
Pathophysiology of erectile dysfunction.
Neoplasms
Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking ?-catenin and MAPK signaling.
Neoplasms
PKG II effectively reversed EGF-induced protein expression alterations in human gastric cancer cell lines.
Neoplasms
Protein Kinases Type II (PKG II) Combined with L-Arginine Significantly Ameliorated Xenograft Tumor Development: Is L-Arginine a Potential Alternative in PKG II Activation?
Neoplasms
Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human lymphocytes.
Neoplasms
Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability.
Neoplasms
Sulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/?-Catenin Signaling.
Neoplasms
Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells.
Neoplasms
The constitutively active PKG II mutant effectively inhibits gastric cancer development
Neoplasms
The interaction between the Wnt/?-catenin signaling cascade and PKG activation in cancer.
Neoplasms
The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization.
Neoplasms
Tumor necrosis factor-alpha-induced activating protein-1 activity is modulated by nitric oxide-mediated protein kinase G activation.
Neoplasms
Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells.
Neoplasms
Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.
Neoplasms
Type II cGMP?dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells.
Neoplasms
Type II cyclic guanosine monophosphate-dependent protein kinase inhibits epidermal growth factor receptor activation in different cancer cell lines.
Neoplasms
Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation.
Neuralgia
cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression.
Neuralgia
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.
Neuralgia
Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain.
Neuralgia
Oxidant-Induced Activation of cGMP-Dependent Protein Kinase I? Mediates Neuropathic Pain After Peripheral Nerve Injury.
Neuralgia
Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain.
Neuralgia
[Involvement of hippocampal NO/PKG signaling pathway in the accumulative analgesic effect of electroacupuncture stimulation of "Zusanli" (ST 36)-"Yanglingquan"(GB 34) in chronic neuropathic pain rats].
Neuroblastoma
cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells.
Neuroblastoma
Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells.
Obesity
Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity.
Obesity
Overexpression of Constitutively Active PKG-I Protects Female, But Not Male Mice From Diet-Induced Obesity.
Obesity
PKG1? oxidation negatively regulates food seeking behaviour and reward.
Osteosarcoma
Cyclic Guanosine Monophosphate (cGMP)-Dependent Protein Kinase II Blocks Epidermal Growth Factor (EGF)/Epidermal Growth Factor Receptor (EGFR)-Induced Biological Effects on Osteosarcoma Cells.
Ovarian Neoplasms
Active PKG II inhibited the growth and migration of ovarian cancer cells through blocking Raf/MEK and PI3K/Akt signaling pathways.
Ovarian Neoplasms
Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive and prognostic factors for therapy response and survival in high-grade serous ovarian cancer.
Ovarian Neoplasms
Protein kinase G type Ialpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation.
Paralysis
The protein kinase G orthologs, EGL-4 and PKG-2, mediate serotonin-induced paralysis of C. elegans.
Parkinson Disease
Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition.
Peripheral Nerve Injuries
Oxidant-Induced Activation of cGMP-Dependent Protein Kinase I? Mediates Neuropathic Pain After Peripheral Nerve Injury.
Peripheral Nervous System Diseases
Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain.
Peripheral Nervous System Diseases
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Pheochromocytoma
Phosphorylation of tyrosine hydroxylase by cyclic GMP-dependent protein kinase.
Plasmacytoma
Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma.
Pneumonia
Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G.
Pre-Eclampsia
Abnormal cGMP-dependent protein kinase I-mediated decidualization in preeclampsia.
Priapism
Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress.
Prostatic Hyperplasia
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Pulmonary Disease, Chronic Obstructive
A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation.
Reperfusion Injury
ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.
Reperfusion Injury
Molecular aspects of ischaemic postconditioning.
Retinoblastoma
Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor.
Retinoblastoma
Overexpression of protein kinase G using adenovirus inhibits cyclin E transcription and mesangial cell cycle.
Sarcoma
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
Sarcoma, Avian
Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus.
Sarcoma, Avian
Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus.
Scoliosis
Upregulation of cGMP-dependent Protein Kinase (PRKG1) in the Development of Adolescent Idiopathic Scoliosis.
Seizures
Contribution of a natural polymorphism in protein kinase G modulates electroconvulsive seizure recovery in Drosophila melanogaster.
Seizures
Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Sepsis
Protein kinase G oxidation is a major cause of injury during sepsis.
Shock, Septic
[Effect of protein kinase on endothelial cytoskeleton induced by septic shock]
Sleep Deprivation
foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila.
Stomach Neoplasms
Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine monophosphate-dependent protein kinase.
Stomach Neoplasms
PKG II effectively reversed EGF-induced protein expression alterations in human gastric cancer cell lines.
Stomach Neoplasms
PKG II inhibits EGF/EGFR-induced migration of gastric cancer cells.
Stomach Neoplasms
PKG II inhibits PDGF-BB triggered biological activities by phosphorylating PDGFR? in gastric cancer cells.
Stomach Neoplasms
PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells.
Stomach Neoplasms
The constitutively active PKG II mutant effectively inhibits gastric cancer development
Stomach Neoplasms
Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells.
Stomach Neoplasms
Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells.
Stomach Neoplasms
Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.
Stomach Neoplasms
Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase/Akt signal transduction in gastric cancer cells.
Stomach Neoplasms
Type II cGMP-dependent protein kinase inhibits ERK/JNK-mediated activation of transcription factors in gastric cancer cells.
Stomach Neoplasms
Type II cGMP-dependent protein kinase inhibits ligand?induced activation of EGFR in gastric cancer cells.
Stomach Neoplasms
Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823.
Stomach Neoplasms
Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation.
Stomach Neoplasms
Type II cGMP?dependent protein kinase inhibits RhoA activation in gastric cancer cells.
Stomach Neoplasms
Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells.
Stomatitis
Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I.
Tachycardia
Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
Thalassemia
Killing me softly - suicidal erythrocyte death.
Thalassemia
Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes.
Thalassemia
Physiology and pathophysiology of eryptosis.
Thrombocytopenia
Prediction of the post-translational modification sites on dengue virus E protein and deciphering their role in pathogenesis.
Thrombocytosis
Thrombocytosis as a response to high interleukin-6 levels in cGMP-dependent protein kinase I mutant mice.
Thymoma
The nitric oxide-cGKII system relays death and survival signals during embryonic retinal development via AKT-induced CREB1 activation.
Toxoplasmosis
Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor.
Toxoplasmosis
Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy.
Toxoplasmosis
Molecular characterization of a coccidian parasite cGMP dependent protein kinase.
Tuberculosis
A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development.
Tuberculosis
An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.
Tuberculosis
Chemical shift assignment of the intrinsically disordered N-terminus and the rubredoxin domain in the folded metal bound and unfolded oxidized state of mycobacterial protein kinase G.
Tuberculosis
Correction: Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host.
Tuberculosis
Exploring prospects of novel drugs for tuberculosis.
Tuberculosis
Expression and purification of the natively disordered and redox sensitive metal binding regions of Mycobacterium tuberculosis protein kinase G.
Tuberculosis
Identification of mycobacterial GarA as a substrate of protein kinase G from M. tuberculosis using a KESTREL-based proteome wide approach.
Tuberculosis
Identification of Novel Mycobacterial Inhibitors Against Mycobacterial Protein Kinase G.
Tuberculosis
Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis.
Tuberculosis
Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host.
Tuberculosis
M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival.
Tuberculosis
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity.
Tuberculosis
NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G.
Tuberculosis
Oxidative Unfolding of the Rubredoxin Domain and the Natively Disordered N-terminal Region Regulate the Catalytic Activity of Mycobacterium tuberculosis Protein Kinase G.
Tuberculosis
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
Tuberculosis
Predictive Binding Affinity of Plant-Derived Natural Products Towards the Protein Kinase G Enzyme of Mycobacterium tuberculosis (MtPknG).
Tuberculosis
Protein Kinase G confers survival advantage to Mycobacterium tuberculosis during latency like conditions.
Tuberculosis
Regulation of glutamate metabolism by protein kinases in mycobacteria.
Tuberculosis
Sclerotiorin inhibits protein kinase G from Mycobacterium tuberculosis and impairs mycobacterial growth in macrophages.
Tuberculosis
Serine/threonine protein kinases PknF and PknG of Mycobacterium tuberculosis: characterization and localization.
Tuberculosis
Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.
Urinary Bladder Neck Obstruction
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Vascular System Injuries
Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4.
Vascular System Injuries
Transcriptional and post-transcriptional regulation of cGMP-dependent protein kinase (PKG-I): pathophysiological significance.
Whooping Cough
Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor.
Whooping Cough
Atrial natriuretic peptide clearance receptor participates in modulating endothelial permeability.
Whooping Cough
C?type natriuretic peptide prevents angiotensin II?induced atrial connexin 40 and 43 dysregulation by activating AMP?activated kinase signaling.
Whooping Cough
Cyclic GMP-dependent protein kinase blocks pertussis toxin-sensitive hormone receptor signaling pathways in Chinese hamster ovary cells.
Whooping Cough
Ghrelin signalling in guinea-pig femoral artery smooth muscle cells.
Whooping Cough
Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways.
Whooping Cough
Pertussis toxin-sensitive and insensitive guanine nucleotide binding proteins (G-proteins) are not phosphorylated by cyclic GMP-dependent protein kinase.
Whooping Cough
Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.
Whooping Cough
Signal transduction and Ca2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium.
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2.7.11.12 cGMP-dependent protein kinase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
