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Information on EC 2.7.11.1 - non-specific serine/threonine protein kinase and Organism(s) Homo sapiens and UniProt Accession Q8WZ42

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IUBMB Comments
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
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This record set is specific for:
Homo sapiens
UNIPROT: Q8WZ42
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase a, 14-3-3, camkii, p-akt, lrrk2, c-jun n-terminal kinase, serine/threonine kinase, raf-1, protein kinase b, gsk-3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Titin, heart isoform N2-B
-
3-phosphoinositide dependent protein kinase-1
-
3-phosphoinositide-dependent kinase 1
-
-
5'-AMP-activated protein kinase, catalytic alpha-1 chain
-
5'-AMP-activated protein kinase, catalytic alpha-2 chain
-
90S6K
-
-
A-kinase
-
-
-
-
A-T, mutated
-
-
-
-
A-T, mutated homolog
-
-
-
-
Akt protein kinase
-
AMH type II receptor
-
-
-
-
AMPK
-
-
Anti-sigma B factor rsbT
-
-
-
-
AP50 kinase
-
-
-
-
Ataxia telangiectasia mutated
-
-
-
-
Ataxia telangiectasia mutated homolog
-
-
-
-
ataxia- and Rad3-related
-
Ataxia-telangiectasia and Rad3-Related
-
ataxia-telangiectasia mutated
-
ATP-protein transphosphorylase
-
-
-
-
betaIIPKC
-
-
-
-
Breast-tumor-amplified kinase
-
-
-
-
Calcium-dependent protein kinase C
-
-
-
-
Calcium/phospholipid-dependent protein kinase
-
-
-
-
cAMP-dependent protein kinase A
-
-
-
-
casein kinase
-
-
-
-
casein kinase 1
-
-
casein kinase 1 delta
-
casein kinase 1 gamma1
-
casein kinase 1alpha
-
-
casein kinase 1delta
-
casein kinase 2
casein kinase 2alpha
-
-
casein kinase I
casein kinase I gamma 2
-
casein kinase I, alpha isoform
-
casein kinase I, delta isoform
-
casein kinase I, epsilon isoform
-
casein kinase I, gamma 1 isoform
-
casein kinase I, gamma 2 isoform
-
casein kinase I, gamma 3 isoform
-
casein kinase II
casein kinase-2
casein kinase-II
-
-
CDC25 suppressing protein kinase
-
-
-
-
Cdc7 kinase
Cdc7Hs protein
-
CDK2
-
-
Cell division cycle 2-like
-
-
-
-
cell division cycle 7-related protein kinase
-
checkpoint kinase 1
-
-
CK-2
-
-
-
-
CK-2alpha
-
CK1alpha
-
-
CK1delta
CK1epsilon
-
-
CK1gamma
-
-
CK2-alpha
-
-
-
-
CKI
-
-
-
-
CLP-36 interacting kinase
-
-
-
-
cyclic monophosphate-dependent protein kinase
-
-
-
-
cyclic nucleotide-dependent protein kinase
-
-
-
-
cyclin-dependent kinase
-
-
-
-
cyclin-dependent kinase 2
-
-
cyclin-dependent kinase 5
-
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
-
-
-
-
DAP-kinase
-
-
death-associated protein kinase 1
-
DM kinase
-
DNA-dependent protein kinase catalytic subunit
-
DNA-PKcs
DNPK1
-
-
-
-
dSTPK61
-
-
-
-
G11 protein
-
-
-
-
glycogen synthase kinase 3
glycogen synthase kinase 3 beta
-
-
glycogen synthase kinase 3beta
-
-
glycogen synthase kinase-3
-
-
glycogen synthase kinase-3alphabeta
-
-
glycogen synthase kinase-3beta
-
-
GSK-3beta
-
-
hARK1
-
-
-
-
HIPK2
-
-
histone kinase
-
-
-
-
homeodomain-interacting protein kinase 2
hPDK1
-
-
-
-
Hpr kinase
-
-
-
-
hPSK
-
-
-
-
HSPK 21
-
-
-
-
HSPK 36
-
-
-
-
hydroxyalkyl-protein kinase
-
-
-
-
insulin-stimulated protein kinase
-
Kinase interacting with stathmin
-
-
-
-
kinase, casein (phosphorylating)
-
-
-
-
kinase, protamine (phosphorylating)
-
-
-
-
kinase, protein (phosphorylating)
-
-
-
-
kinase, protein, A (phosphorylating)
-
-
-
-
kinase, protein, C (phosphorylating)
-
-
-
-
leucine-rich repeat kinase 2
-
-
LIM domain kinase 1
-
LKB1
-
-
LRRK2
-
-
Lymphocyte-oriented kinase
-
-
-
-
M phase-specific cdc2 kinase
-
-
-
-
MAP kinase activated protein kinase 2
-
MAP kinase-activated protein kinase 2
-
MAPK-activated protein kinase 2
-
-
MAPKAP kinase-2
-
MAPKAP-K2
-
-
mitogen-activated S6 kinase
-
-
-
-
mitotic checkpoint serine/threonine-protein kinase BUB1
-
mitotic checkpoint serine/threonine-protein kinase BUB1 beta
-
MLK4
-
-
mPDK1
-
-
-
-
MPSK
-
-
-
-
Myristoylated and palmitoylated serine-threonine kinase
-
-
-
-
NDR protein kinase
-
-
nuclear Dbf2-related 1
-
nuclear Dbf2-related protein kinase
-
-
NY-REN-55 antigen
-
-
-
-
p-AKT
-
-
P-CIP2
-
-
-
-
p110alpha
-
p21-activated kinase 4
-
P460
-
-
-
-
p46Eg265
-
-
-
-
p46XlEg22
-
-
-
-
p53-related protein kinase
-
p54 S6 kinase 2
-
p70 S6 kinase
-
p82 kinase
-
-
-
-
pEg2
-
-
-
-
peripheral plasma membrane protein CASK
-
phosphatidylinositol 3-kinase
-
phosphatidylinositol 3-kinase-related kinase
-
phosphoinositide 3-kinase
phosphorylase b kinase kinase
-
-
-
-
Phototropin
-
-
-
-
PI3Kdelta
-
PI3Kgamma
-
Pim-2
-
-
Pim-2h
-
-
-
-
Pim1 serine/threonine kinase
-
PkB kinase
-
-
-
-
PKBalpha
-
-
PKD1
-
-
PKD2
-
-
PKN1
-
-
pp39-mos
-
-
-
-
pp90rsk Ser/Thr kinase
-
Pre-mRNA protein kinase
-
-
-
-
protamine kinase
-
-
-
-
protein casein kinase II
-
-
protein glutamyl kinase
-
-
-
-
protein kinas B
-
-
protein kinase (phosphorylating)
-
-
-
-
protein kinase A
-
-
protein kinase B
-
protein kinase B alpha
-
Protein kinase B kinase
-
-
-
-
protein kinase B/Akt
-
-
protein kinase Balpha
-
-
protein kinase Bgamma
-
protein kinase C
-
-
protein kinase CK2
protein kinase D1
-
-
protein kinase D2
-
-
protein kinase HIPK2
-
Protein kinase Krct
-
-
-
-
Protein kinase MST
-
-
-
-
protein kinase N1
-
-
protein kinase p58
-
-
-
-
Protein kinase PKL12
-
-
-
-
protein kinase PKX1
-
protein kinase Sgk
-
protein phosphokinase
-
-
-
-
protein serine kinase
-
-
-
-
protein serine-threonine kinase
-
-
-
-
protein serine/threonine kinase
-
-
protein-aspartyl kinase
-
-
-
-
protein-cysteine kinase
-
-
-
-
protein-serine kinase
-
-
-
-
protein-serine/threonine kinase
-
-
-
-
PRP4 kinase
-
-
-
-
PRP4 pre-mRNA processing factor 4 homolog
-
-
-
-
PSK-H1
-
-
-
-
RAC-alpha serine/threonine kinase
-
RAC-beta serine/threonine protein kinase
-
RAC-gamma serine/threonine protein kinase
-
RAC/Akt kinase
-
Raf kinase
-
-
-
-
RAF proto-oncogene serine/threonine-protein kinase
-
-
Raf-1
-
-
-
-
ratAurA
-
-
-
-
ribosomal protein S6 kinase
-
ribosomal protein S6 kinase alpha 1
-
ribosomal protein S6 kinase alpha 2
-
ribosomal protein S6 kinase alpha 3
-
ribosomal protein S6 kinase alpha 6
-
ribosomal protein S6 kinase beta 2
-
ribosomal protein S6 kinase II
-
-
-
-
ribosomal S6 kinase (Rsk-2)
-
ribosomal S6 protein kinase
-
-
-
-
RP1 protein
-
-
-
-
S-receptor kinase
-
-
-
-
S6K1alphaII
-
-
serine kinase
-
-
-
-
serine protein kinase
-
-
-
-
serine threonine tyrosine kinase 1
-
-
serine(threonine) protein kinase
-
-
-
-
serine-specific protein kinase
-
-
-
-
serine-threonine kinase
serine-threonine kinase 38
-
serine-threonine protein kinase
-
serine/threonine kinase
serine/threonine kinase 11
-
-
Serine/threonine kinase 15
-
-
-
-
serine/threonine kinase 17A
-
serine/threonine kinase 17B
-
serine/threonine kinase 38
-
Serine/threonine kinase Ayk1
-
-
-
-
serine/threonine kinase PRP4 homolog
-
serine/threonine protein kinase
serine/threonine protein kinase 16
-
serine/threonine protein kinase 31
-
serine/threonine protein kinase R (PKR)-like endoplasmic reticulum kinase
-
serine/threonine-protein kinase
serine/threonine-protein kinase 11
-
serine/threonine-protein kinase Chk1
-
serine/threonine-protein kinase Chk2
-
serine/threonine-protein kinase DCAMKL1
-
serine/threonine-protein kinase H1
-
serine/threonine-protein kinase NEK2
-
serine/threonine-protein kinase NEK3
-
Serine/threonine-protein kinase NRK2
-
-
-
-
Serine/threonine-protein kinase NYD-SPK
-
-
-
-
serine/threonine-protein kinase PAK 1
-
serine/threonine-protein kinase PAK 2
-
serine/threonine-protein kinase PAK 3
-
serine/threonine-protein kinase PAK 4
-
serine/threonine-protein kinase PAK 7
-
serine/threonine-protein kinase Sgk
-
serine/threonine-protein kinase ULK1
-
SGK1
-
-
SPAK/STE20
-
SPS1-related proline alanine-rich kinase
-
SRK
-
-
-
-
Ste20-like kinase
-
-
-
-
STE20-like kinase MST1
-
-
-
-
STE20-like kinase MST2
-
-
-
-
STE20-like kinase MST3
-
-
-
-
Ste20-related protein kinase
-
STE20/SPS1-related proline-alanine rich protein kinase
-
STK11
STYK1
-
-
suppressor of morphogenesis in genitalia-1
-
Switch protein/serine kinase
-
-
-
-
T-antigen kinase
-
-
-
-
tau-protein kinase I
-
-
Tau-tubulin kinase 1
-
-
testis-specific serine/threonine kinase
-
testis-specific serine/threonine kinase 2
-
threonine Pim kinase
-
threonine-specific protein kinase
-
-
-
-
TPK I
-
-
Twitchin kinase
-
-
-
-
type-2 casein kinase
-
-
-
-
ZIP kinase
-
-
ZIPK
-
-
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (non-specific)
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
CAS REGISTRY NUMBER
COMMENTARY hide
191808-15-8
phosphoinositide dependent protein kinase 1
340830-03-7
-
37278-10-7
-
377752-08-4
ribosomal protein S6 kinase 2
389133-24-8
ribosomal S6 kinase 3
52660-18-1
casein kinase, protein kinase CK2
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
90698-26-3
ribosomal protein S6 kinase 1
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 4E-BP1 protein
ADP + phosphorylated 4E-BP1 protein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + ABCA1 NBD1-R1 protein
ADP + phosphorylated ABCA1 NBD1-R1 protein
show the reaction diagram
-
substrate protein is a recombinant construct of wild-type and mutant nucleotide binding domain 1 and cytoplasmic domain R1 of ATP-binding cassette transporter protein A1 expressed in Escherichia coli, phosphorylation at T1242, T1243, and S1255
-
-
?
ATP + ABCA1 NBD2-R2 protein
ADP + phosphorylated ABCA1 NBD2-R2 protein
show the reaction diagram
-
substrate protein is a recombinant construct of wild-type and mutant nucleotide binding domain 2 and cytoplasmic domain R2 of ATP-binding cassette transporter protein A1 expressed in Escherichia coli
-
-
?
ATP + Ac-RPRAASF
ADP + Ac-Ac-RPRAApSF
show the reaction diagram
an efficient fluorescence assay for serine/threonine kinases using a peptide array is developed. Assay is based on chemical reactions specific to phosphoserine and phosphothreonine residues, that is, base-mediated beta-elimination of the phosphate group and subsequent Michael addition of a thiol-containing fluorescent reagent. This procedure enables the covalent introduction of a fluorescent moiety into the phosphorylated peptide. Novel fluorescent reagents are designed for this purpose and synthesized
-
-
?
ATP + acetyl-CoA carboxylase
ADP + phosphorylated acetyl-CoA carboxylase
show the reaction diagram
phosphorylation and inactivation
-
-
?
ATP + adenomatous polyposis coli protein
ADP + phosphorylated adenomatous polyposis coli protein
show the reaction diagram
-
i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon
-
-
?
ATP + AIB1 protein
ADP + phosphorylated AIB1 protein
show the reaction diagram
-
phosphorylation at S601 by isozyme CK1delta
-
-
?
ATP + AKAP450
ADP + phospho-AKAP450
show the reaction diagram
ATP + alpha-casein
ADP + phosphorylated alpha-casein
show the reaction diagram
-
casein kinase 1alpha
-
-
?
ATP + AMP-activated protein kinase alpha1
ADP + phospho-AMP-activated protein kinase
show the reaction diagram
phosphorylation of Ser485 at subunit alpha1 and of Ser491 at subunit alpha2
-
-
?
ATP + ataxin-3 protein
ADP + phosphorylated ataxin-3 protein
show the reaction diagram
-
phosphorylation at serines 340 and 352
-
-
?
ATP + axin
ADP + phosphorylated axin
show the reaction diagram
glycogen synthase kinase 3
-
-
?
ATP + BAF155
ADP + phosphorylated BAF155
show the reaction diagram
ATP + BAF170
ADP + phosphorylated BAF170
show the reaction diagram
-
BAF170 is a hSWI/SNF protein that contains one Akt consensus site
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
ATP + beta-hydroxy beta-methylglutaryl-coenzyme A reductase
ADP + phosphorylated beta-hydroxy beta-methylglutaryl-coenzyme A reductase
show the reaction diagram
phosphorylation and inactivation
-
-
?
ATP + calmodulin
ADP + phosphorylated calmodulin
show the reaction diagram
-
phosphorylation by isozyme CK1alpha
-
-
?
ATP + CARMA1 protein
ADP + phosphorylated CARMA1
show the reaction diagram
-
i.e. CARD11 protein, phosphorylation at S608 by isozyme CK1alpha
-
-
?
ATP + CDC25A
ADP + phospho-CDC25A
show the reaction diagram
ATP + Cdc25A
ADP + phosphorylated Cdc25A
show the reaction diagram
ATP + Cdc25C
ADP + ?
show the reaction diagram
Chk2 phosphorylated Cdc25C on Ser216
-
-
?
ATP + Cdc42Hs
ADP + ?
show the reaction diagram
PAK4 interacts only with the activated form of Cdc42Hs through its GTPase-binding domain
-
-
?
ATP + Cdk2 interacting protein
ADP + phosphorylated Cdk2 interacting protein
show the reaction diagram
-
-
-
-
?
ATP + cell division cycle 7
ADP + phosphorylated cell division cycle 7
show the reaction diagram
-
-
-
-
?
ATP + claspin
ADP + phosphorylated claspin
show the reaction diagram
-
-
-
-
?
ATP + CREB
ADP + phosphorylated CREB
show the reaction diagram
ATP + Daxx
ADP + phosphorylated Daxx
show the reaction diagram
ATP + Dnmt1 protein
ADP + phosphorylated Dnmt1 protein
show the reaction diagram
-
phosphorylation at S147 by isozymes CK1delta and CK1epsilon
-
-
?
ATP + FADD protein
ADP + phosphorylated FADD protein
show the reaction diagram
-
phosphorylation at S194 by isozyme CK1alpha
-
-
?
ATP + geminin
ADP + phosphorylated geminin
show the reaction diagram
ATP + Gli protein
ADP + phosphorylated Gli protein
show the reaction diagram
ATP + Gli1 protein
ADP + phosphorylated Gli1 protein
show the reaction diagram
low activity
-
-
?
ATP + Gli2 protein
ADP + phosphorylated Gli2 protein
show the reaction diagram
high activity
-
-
?
ATP + Gli3 protein
ADP + phosphorylated Gli3 protein
show the reaction diagram
low activity
-
-
?
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
show the reaction diagram
ATP + glycogen synthase kinase 3
ADP + phosphorylated glycogen synthase kinase 3
show the reaction diagram
ATP + glycogen synthase kinase-3 (GSK-3) fusion protein
ADP + phosphorylated- glycogen synthase kinase-3 fusion protein
show the reaction diagram
-
-
-
?
ATP + granulocyte macrophage colony stimulating factor receptor
ADP + phospho-granulocyte macrophage colony stimulating factor receptor
show the reaction diagram
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
ATP + histone H2A
ADP + phosphorylated histone H2A
show the reaction diagram
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2AX
ADP + phosphorylated histone H2AX
show the reaction diagram
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2B
ADP + phosphorylated histone H2B
show the reaction diagram
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H4
ADP + phosphorylated histone H4
show the reaction diagram
recombinant substrate from Xenopus laevis, substrate of SSTK
-
-
?
ATP + hypoxia-inducible factor-1
ADP + phosphorylated hypoxia-inducible factor-1
show the reaction diagram
ATP + IFNAR1 protein
ADP + phosphorylated IFNAR1 protein
show the reaction diagram
-
phosphorylation at S535 by isozyme CK1alpha
-
-
?
ATP + IKKalpha protein
ADP + phosphorylated IKKalpha protein
show the reaction diagram
-
-
-
-
?
ATP + interleukin 3
ADP + phospho-interleukin-3
show the reaction diagram
ATP + KKRNRRLSVA
ADP + KKRNRRL-phosphoserine-VA
show the reaction diagram
-
peptide substrate of NDR1
-
-
?
ATP + KKRNRRLSVA
ADP + phosphorylated-KKRNRRLSVA
show the reaction diagram
-
-
-
?
ATP + KLP10A protein
ADP + phosphorylated KLP10A protein
show the reaction diagram
-
phosphorylation at S573 by isozyme CK1alpha
-
-
?
ATP + L-seryl-[Eukaryotic initiation factor 2]
ADP + H+ + O-phospho-L-seryl-[Eukaryotic initiation factor 2]
show the reaction diagram
-
-
-
?
ATP + Lys-Lys-Phe-Asn-Arg-Thr-Leu-Ser-Val-Ala
ADP + ?
show the reaction diagram
ATP + M3-muscarnic receptor
ADP + phosphorylated M3-muscarnic receptor
show the reaction diagram
-
-
-
-
?
ATP + MARCKS protein
ADP + MARCKS phosphoprotein
show the reaction diagram
-
isozyme PKNalpha
-
-
?
ATP + MB protein
ADP + MB phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + MCM2
ADP + ?
show the reaction diagram
wild-type huCdc7 protein expressed in COS7 cells phosphorylates MCM2 and MCM3 proteins in vitro
-
-
?
ATP + MCM3
ADP + ?
show the reaction diagram
wild-type huCdc7 protein expressed in COS7 cells phosphorylates MCM2 and MCM3 proteins in vitro
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
ATP + non-structural protein 2
ADP + phospho-non-structural protein 2
show the reaction diagram
-
non-structural protein 2 from bluetongue virus (BTV)
-
-
?
ATP + non-structural protein 2
ADP + phosphorylated non-structural protein 2
show the reaction diagram
-
-
-
-
?
ATP + NS5A protein
ADP + phosphorylated NS5A protein
show the reaction diagram
-
recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by several STE or AGC type protein kinases CK2, AKT1, SGK1, 90S6K, STE, phosphorylation patterns, overview
-
-
?
ATP + OTUB1
ADP + phospho-OTUB1
show the reaction diagram
-
OTUB1 is a tumor domain protease, phosphorylation at Ser16, in GSDSEGVN
-
-
?
ATP + OTUB1 protein
ADP + phosphorylated OTUB1 protein
show the reaction diagram
-
phosphorylation at serine 16
-
-
?
ATP + OTUD5 protein
ADP + phosphorylated OTUD5 protein
show the reaction diagram
-
phosphorylation at serine 177
-
-
?
ATP + p35
ADP + phosphorylated p35
show the reaction diagram
-
-
-
?
ATP + peptide LRRKtide
ADP + phosphorylated peptide LRRKtide
show the reaction diagram
-
high activity towards the peptidic substrate LRRKtide
-
-
?
ATP + PHLPP1 protein
ADP + phosphorylated PHLPP1 protein
show the reaction diagram
-
phosphorylation at T851 by isozyme CK1alpha
-
-
?
ATP + phospho-glycogen synthase peptide
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + phosphoglycogen synthase peptide 2
ADP + phosphorylated phosphoglycogen synthase peptide 2
show the reaction diagram
-
-
-
-
?
ATP + phospholipase D
ADP + phosphorylated phospholipase D
show the reaction diagram
ATP + PKB protein kinase
ADP + phosphorylated PKB protein kinase
show the reaction diagram
ATP + PKD2 protein
ADP + phosphorylated PKD2 protein
show the reaction diagram
-
phosphorylation at S244 by isozymes CK1alpha, CK1delta, and CK1epsilon
-
-
?
ATP + procaspase-2
ADP + phosphorylated procaspase-2
show the reaction diagram
ATP + protein
ADP + a phosphoprotein
show the reaction diagram
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes
-
-
?
ATP + protein INI
ADP + phosphorylated INI
show the reaction diagram
-
INI is a hSWI/SNF protein
-
-
?
ATP + protein kinase C
ADP + phosphorylated protein kinase C
show the reaction diagram
-
isozyme PKNalpha
-
-
?
ATP + protein LRP6
ADP + phosphorylated protein LRP6
show the reaction diagram
-
CKIgamma
-
-
?
ATP + protein TCF3
ADP + phosphorylated protein TCF3
show the reaction diagram
-
CKIepsilon
-
-
?
ATP + rapamycin
ADP + phospho-rapamycin
show the reaction diagram
-
-
-
?
ATP + Rec8 protein
ADP + phosphorylated Rec8 protein
show the reaction diagram
-
phosphorylation at S412 by isozyme CK1delta and CK1epsilon, and at S400, S402, S404, S410, T414, and S416
-
-
?
ATP + RRRDDDSDDD
ADP + RRRDDDphosphoSDDD
show the reaction diagram
-
a CK2-specific synthetic peptide substrate
-
-
?
ATP + RRRLSSLRA
ADP + RRRLSpSLRA
show the reaction diagram
-
enzyme activities are determined by measuring initial velocities for His6-S6K1aII(DELTA AID)-T389E catalyzed phosphorylation of a commercially available S6K/RSK model peptide substrate 1 (S6K1-Tide, RRRLSSLRA)
-
-
?
ATP + RSRSRSRSRSRSPPPVSK
ADP + phosphorylated RSRSRSRSRSRSPPPVSK
show the reaction diagram
-
SC35-derived peptide 180-197, recombinant GSK-3beta
-
-
?
ATP + SC35
ADP + phosphorylated SC35
show the reaction diagram
ATP + SF2/ASF
ADP + phosphorylated SF2/ASF
show the reaction diagram
ATP + SIV/17E-Fr Nef protein
ADP + phosphorylated SIV/17E-Fr Nef protein
show the reaction diagram
ATP + SLR1 protein
ADP + phosphorylated SLR1 protein
show the reaction diagram
-
phosphorylation at S196 and SS510
-
-
?
ATP + Snail protein
ADP + phosphorylated Snail protein
show the reaction diagram
-
phosphorylation at S104 and S07 by isozyme CK1epsilon
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
enzyme plays a role as a co-repressor for homeodomain transcription factors
-
-
?
ATP + Src protein
ADP + phosphorylated Src protein
show the reaction diagram
ATP + SSH1L protein
ADP + SSH1L phosphoprotein
show the reaction diagram
-
PKD1 phosphorylates the SSH enzyme SSH1L at serine 978
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
ATP + TRPM4
ADP + phospho-TRPM4
show the reaction diagram
-
i.e. transient receptor potential melastatin-like 4, phosphorylation at Ser839
-
-
?
ATP + TRPM4 protein
ADP + phosphorylated TRPM4 protein
show the reaction diagram
-
phosphorylation at serine 839
-
-
?
ATP + Varicella-Zoster viral gB protein
ADP + phosphorylated Varicella-Zoster viral gB protein
show the reaction diagram
-
phosphorylation at S34 in the sequence QSEDIT
-
-
?
ATP + vimentin
ADP + phosphorylated vimentin
show the reaction diagram
-
isozyme PKNalpha
-
-
?
ATP + YAP protein
ADP + phosphorylated YAP protein
show the reaction diagram
-
phosphorylation at S384 and S387 by isozymes CK1delta and CK1epsilon
-
-
?
ATP + [FRAT-2 protein]
ADP + phosphorylated [FRAT-2 protein]
show the reaction diagram
-
i.e. frequently rearranged in advanced T-cell lymphoma protein 2, phosphorylation by GSK3beta
-
-
?
ATP + [M3 muscarinic acetylcholine receptor]
ADP + phospho-[M3 muscarinic acetylcholine receptor]
show the reaction diagram
-
recombinant substrate expressed in HEK-293 and CHO cells, casein kinase 1alpha
-
-
?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
show the reaction diagram
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 4E-BP1 protein
ADP + phosphorylated 4E-BP1 protein
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + adenomatous polyposis coli protein
ADP + phosphorylated adenomatous polyposis coli protein
show the reaction diagram
-
i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon
-
-
?
ATP + AKAP450
ADP + phospho-AKAP450
show the reaction diagram
-
-
-
?
ATP + alpha-casein
ADP + phosphorylated alpha-casein
show the reaction diagram
-
casein kinase 1alpha
-
-
?
ATP + AMP-activated protein kinase alpha1
ADP + phospho-AMP-activated protein kinase
show the reaction diagram
phosphorylation of Ser485 at subunit alpha1 and of Ser491 at subunit alpha2
-
-
?
ATP + ataxin-3 protein
ADP + phosphorylated ataxin-3 protein
show the reaction diagram
-
phosphorylation at serines 340 and 352
-
-
?
ATP + axin
ADP + phosphorylated axin
show the reaction diagram
glycogen synthase kinase 3
-
-
?
ATP + BAF155
ADP + phosphorylated BAF155
show the reaction diagram
-
-
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
ATP + CDC25A
ADP + phospho-CDC25A
show the reaction diagram
STK38 phosphorylates CDC25A at Ser76
-
-
?
ATP + Cdc25A
ADP + phosphorylated Cdc25A
show the reaction diagram
phosphorylation site Ser76
-
-
?
ATP + Cdk2 interacting protein
ADP + phosphorylated Cdk2 interacting protein
show the reaction diagram
-
-
-
-
?
ATP + cell division cycle 7
ADP + phosphorylated cell division cycle 7
show the reaction diagram
-
-
-
-
?
ATP + claspin
ADP + phosphorylated claspin
show the reaction diagram
-
-
-
-
?
ATP + CREB
ADP + phosphorylated CREB
show the reaction diagram
phosphorylation by TSSK5 at Ser133 stimulates the cAMP responsive element/cAMP responsive element binding protein CRE/CREB responsive pathway in recombinant HEK293 cells
-
-
?
ATP + Daxx
ADP + phosphorylated Daxx
show the reaction diagram
-
Daxx is a protein acting in TGF-beta-induced JNK activation and in apoptosis
-
-
?
ATP + geminin
ADP + phosphorylated geminin
show the reaction diagram
-
a cell cycle regulatory protein
-
-
?
ATP + Gli protein
ADP + phosphorylated Gli protein
show the reaction diagram
-
the Gli proteins are important in regulation of Hedgehog signaling, overview
-
-
?
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
show the reaction diagram
glycogen synthase kinase 3 is involved in the insulin signaling pathway regulating glycogen synthesis via glycogen synthase antagonizing insulin
-
-
?
ATP + glycogen synthase kinase 3
ADP + phosphorylated glycogen synthase kinase 3
show the reaction diagram
PKB protein kinase
-
-
?
ATP + granulocyte macrophage colony stimulating factor receptor
ADP + phospho-granulocyte macrophage colony stimulating factor receptor
show the reaction diagram
-
-
-
?
ATP + hypoxia-inducible factor-1
ADP + phosphorylated hypoxia-inducible factor-1
show the reaction diagram
-
i.e. HIF-1, casein kinase 2 inhibits the activation of HIF-1 activity by phosphorylation and thereby stabilization of the protein, CK2 is involved in and influenced by hypoxia, overview
-
-
?
ATP + IKKalpha protein
ADP + phosphorylated IKKalpha protein
show the reaction diagram
-
-
-
-
?
ATP + interleukin 3
ADP + phospho-interleukin-3
show the reaction diagram
-
-
-
?
ATP + L-seryl-[Eukaryotic initiation factor 2]
ADP + H+ + O-phospho-L-seryl-[Eukaryotic initiation factor 2]
show the reaction diagram
-
-
-
?
ATP + M3-muscarnic receptor
ADP + phosphorylated M3-muscarnic receptor
show the reaction diagram
-
-
-
-
?
ATP + non-structural protein 2
ADP + phosphorylated non-structural protein 2
show the reaction diagram
-
-
-
-
?
ATP + OTUB1
ADP + phospho-OTUB1
show the reaction diagram
-
OTUB1 is a tumor domain protease, phosphorylation at Ser16, in GSDSEGVN
-
-
?
ATP + OTUB1 protein
ADP + phosphorylated OTUB1 protein
show the reaction diagram
-
phosphorylation at serine 16
-
-
?
ATP + OTUD5 protein
ADP + phosphorylated OTUD5 protein
show the reaction diagram
-
phosphorylation at serine 177
-
-
?
ATP + peptide LRRKtide
ADP + phosphorylated peptide LRRKtide
show the reaction diagram
-
high activity towards the peptidic substrate LRRKtide
-
-
?
ATP + phospholipase D
ADP + phosphorylated phospholipase D
show the reaction diagram
-
CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity
-
-
?
ATP + PKB protein kinase
ADP + phosphorylated PKB protein kinase
show the reaction diagram
PDK1 kinase, phosphorylates Thr308 and Ser473, which is required for activation of PKB
-
-
?
ATP + procaspase-2
ADP + phosphorylated procaspase-2
show the reaction diagram
-
phosphorylation of procaspase-2 by CK2 prevents the activation of caspase activity by inhibiting the dimerization of procaspase-2, CK2 activity is involved in the direct regulation of the caspase-8 pathway, where it can control caspase-8 activity through the phosphorylation of ARC or by preventing the ability of caspase-8 to cleave its target Bid
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes
-
-
?
ATP + protein LRP6
ADP + phosphorylated protein LRP6
show the reaction diagram
-
CKIgamma
-
-
?
ATP + protein TCF3
ADP + phosphorylated protein TCF3
show the reaction diagram
-
CKIepsilon
-
-
?
ATP + rapamycin
ADP + phospho-rapamycin
show the reaction diagram
-
-
-
?
ATP + SC35
ADP + phosphorylated SC35
show the reaction diagram
-
substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors
-
-
?
ATP + SIV/17E-Fr Nef protein
ADP + phosphorylated SIV/17E-Fr Nef protein
show the reaction diagram
-
phosphorylation at Ser12, the protein kinase CK2 associates with the Nef proteins from the Human immunodeficiency virus and the macrophage-tropic neurovirulent Simian immunodeficiency virus clone, SIV/17E-Fr, the Nef protein play important roles in viral disease progression
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
enzyme plays a role as a co-repressor for homeodomain transcription factors
-
-
?
ATP + Src protein
ADP + phosphorylated Src protein
show the reaction diagram
-
-
-
?
ATP + SSH1L protein
ADP + SSH1L phosphoprotein
show the reaction diagram
-
PKD1 phosphorylates the SSH enzyme SSH1L at serine 978
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
-
tau in Alzheimer disease brain is highly phosphorylated and aggregates into paired helical filaments comprising characteristic neurofibrillary tangles, overview
-
-
?
ATP + TRPM4
ADP + phospho-TRPM4
show the reaction diagram
-
i.e. transient receptor potential melastatin-like 4, phosphorylation at Ser839
-
-
?
ATP + TRPM4 protein
ADP + phosphorylated TRPM4 protein
show the reaction diagram
-
phosphorylation at serine 839
-
-
?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
show the reaction diagram
-
tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Zn2+
-
bound to the zinc finger core at residues 105-147 and coordinated by Cys109, Cys114, Cys137 ans Cys140, of the beta subunit dimer
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid
-
i.e. IQA
(5Z)-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene)-2-thioxoimidazolidin-4-one
-
-
(S)-2-(2-aminopyrimidiny-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridinione
-
-
(Z)-5-(4-propoxybenzylidene) thiazolidine-2,4-dione
-
a Pim-2 inhibitor
1,1'-[(5-chloropyrimidine-2,4-diyl)bis[azanediyl(3-methoxy-4,1-phenylene)piperazine-4,1-diyl]]di(ethan-1-one)
-
1-(6-[[4-(2,3-dihydro-1H-indol-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-5-methoxy-2,3-dihydro-1H-indol-1-yl)-2-(dimethylamino)ethan-1-one
-
1-(beta-D-2'-deoxyribofuranosyl)-4,5,6,7-tetrabromo-1H-benzimidazole
-
TDB, a cell-permeable selective inhibitor of CK2, inhibits the phosphorylation of OTUB1 at Ser16. In addition to CK2, TDB inhibits 3 other kinases, namely PIM1, CLK2 and DYRK1A, but none of these kinases phosphorylates OTUB1 in vitro
1-[3-methoxy-4-([6-[2-(propane-2-sulfonyl)anilino]-7H-purin-2-yl]amino)phenyl]piperidin-4-ol
-
2,3-difluoro-6-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
-
2-(2-aminopyrimidin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
-
-
2-([5-bromo-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzene-1-sulfonamide
-
2-([5-chloro-2-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzene-1-sulfonamide
-
2-([5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzene-1-sulfonamide
-
2-([5-chloro-2-[2-methoxy-4-(morpholin-4-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzamide
-
2-([5-chloro-2-[4-(piperazin-1-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzamide
-
2-Aminopurine
-
-
2-chloro-N-(4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)phenyl)benzamide
-
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole
2-fluoro-6-([2-[(5-methoxy-1-[[4-(propan-2-yl)piperazin-1-yl]acetyl]-2,3-dihydro-1H-indol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino)benzamide
-
2-fluoro-6-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzoic acid
-
2-phenyl-5-(pyridin-4-yl)-1H-pyrrole-3-carboxamide
-
-
2-[(2-[4-chloro-2-methoxy-5-[(1-propylpiperidin-4-yl)oxy]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
-
2-[(2-[5-[(N,N-dimethylglycyl)(methyl)amino]-2-methoxy-4-methylanilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
-
2-[(2-[5-[(N,N-dimethylglycyl)amino]-2-methoxy-4-methylanilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
-
2-[(2-[[1-(N,N-dimethylglycyl)-5-methoxy-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-N-methylbenzamide
-
3,8-dibromo-7-hydroxy-4-methyl-2H-chromen-2-one
-
i.e. DBC
3-[(2-[[1-(N,N-dimethylglycyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methylpyridine-2-carboxamide
-
3-[(2-[[1-(N,N-dimethylglycyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]thiophene-2-carboxamide
-
3-[(2-[[1-(N,N-dimethylglycyl)-6-methoxy-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]thiophene-2-carboxamide
-
3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate
-
-
4,5,6,7-tetrabromo-1H-benzotriazole
-
i.e. TBB
4,5,6,7-tetrabromobenzimidazole
-
i.e. TBBz or TBI
4,5,6,7-tetrabromobenzotriazole
4-(2-(4-(2-(4-acetylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)-N-(2-chlorophenyl)benzamide
-
4-fluoro-2-([2-[2-methoxy-4-(1-propylpiperidin-3-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino)benzamide
-
4-fluoro-2-([2-[2-methoxy-4-(1-propylpiperidin-4-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino)benzamide
-
4-hydroxy-trans-2-nonenal
-
i.e. 4-HNE, binds to the enzyme at Lys197 and inhibits its activity by 69% by inhibiting its posttranslational phosphorylation. 4-HNE binding has no effect on the association of LKB1 with its adaptor proteins, sterile-20-related adaptor and mouse protein 25
5-chloro-N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
-
5-chloro-N2-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-N4-[2-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine
-
5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
-
5-chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine
-
5-fluoro-2-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
-
5-fluoro-N2,N4-bis(4-methoxyphenyl)pyrimidine-2,4-diamine
-
5-fluoro-N2,N4-di(m-tolyl)pyrimidine-2,4-diamine
-
6,7-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)quinazolin-4-amine
elicits selective cytotoxic activity against the pancreas ductal adenocarcinoma (PANC-1) cell line
6-(3-chlorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(1H)-one
-
-
7,9-dimethyl-8-(prop-2-en-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amine
-
-
8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one
-
i.e. NBC
alsterpaullone
-
inhibition of AMPK, GSK3beta, S6K1, PKBalpha, PDK1, MAPKAP-K2
AMP-PNP
-
ATP analogue adenosine 5'-(beta,gamma-imino)triphosphate
apigenin
auoinhibitory domain of S6K1
-
-
AZD-6738
ATR inhibition sensitizes cancer cells to ionizing radiation and chemotherapeutics agents (cisplatin, carboplatin, gemcitabine and bendamustine)
-
Baicalin
-
one of the major compounds in the Chinese medical herb Scutellaria baicalensis, reduces enzyme expression and activity in badder cancer cells T24
benzene 1,2,3,4-tetrakisphosphate
-
-
benzene 1,2,3,5-tetrakisphosphate
-
-
benzene 1,2,3-trisphosphate
-
-
benzene 1,2,4,5-tetrakisphosphate
-
-
benzene 1,2,4-trisphosphate
-
-
benzene 1,3,5-trisphosphate
-
-
biphenyl 2,3',4,5',6-pentakisphosphate
-
-
BMS-863233
-
-
Caffeine
ATM/ATR inhibition sensitizes cancer cells to ionizing radiation, nonspecific inhibitor for ATM and ATR
CP466722
enzyme (ATM) inhibition sensitizes cancer cells to ionizing radiation, evokes defects in cell cycle checkpoints
-
Ctl peptide
-
-
CX-4945
-
a CK2 inhibitor
D-myo-Inositol 1,3,4,5-tetrakisphosphate
-
-
diC8-phosphatidylinositol 3,4,5-trisphosphate
-
-
ellagic acid
-
-
emodin
enzastaurin
ETP-46464
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents non-specific inhibitor for ATR
-
FAALS
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
GSK2606414
-
GSK2656157
-
heparin
-
strongly inhibits casein kinase II
idelalisib
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4(3H)-one, a PI3Kdelta inhibitor used to treat hematological malignancies. The inhibitor idelalisib is selective, noncovalent, reversible, and ATP-competitive, The compound binds reversibly and noncovalently to the p110delta subunit of the kinase, analysis of binding interactions that confer the potency and selectivity of idelalisib, overview. Idelalisib is a propeller-shaped inhibitor
indirubin-3'-monoxime
-
inhibition of AMPK, GSK3beta, S6K1, PKBalpha, PDK1, MAPKAP-K2
JAK3 inhibitor VI
-
-
K252a
-
-
kenpaullone
-
slight inhibition of AMPK, GSK3beta, PKBalpha, PDK1
KU-55933
enzyme (ATM) inhibition sensitizes cancer cells to ionizing radiation and DNA DSBs inducing chemotherapeutics agents
KU-59403
enzyme (ATM) inhibition significant chemosensitization and radiosensitization
-
KU-60019
enzyme (ATM) inhibition sensitizes cancer cells to ionizing radiation
-
LAALS
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
lithium
-
after inhibition of GSK-3 in cortical neurons, the splicing factor SC35 is nuclearly redistributed and enriched in nuclear speckles and colocalizes with the kinase
Ly-294002
-
LY294002
MLN8054
Aurora A-selective inhibitor
N-(2-chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
-
N-(2-chlorophenyl)-4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)benzamide
-
N-cyclopropyl-4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)benzamide
-
N-ethyl-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-3a,6a-dihydro-1H-thieno[3,2-c]pyrazole-5-carboxamide
-
-
N-tert-butyl-3-([5-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino)benzene-1-sulfonamide
-
N-[(2R)-2,3-dihydroxypropyl]-5-fluoro-2-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
-
N-[2-(4-fluorophenyl)ethyl]-5-[2-[(methylsulfonyl)amino]pyrimidin-4-yl]thiophene-2-carboxamide
-
-
N-[2-([5-chloro-2-[2-methoxy-4-(morpholin-4-yl)anilino]pyrimidin-4-yl]amino)phenyl]methanesulfonamide
-
N-[2-([5-fluoro-2-[2-methoxy-4-(morpholin-4-yl)anilino]pyrimidin-4-yl]amino)phenyl]methanesulfonamide
-
N-[3-([2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino)phenyl]prop-2-enamide
-
N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
-
N-[5-(4-fluorophenyl)-1H-pyrazol-3-yl]-6,7-dimethoxyquinazolin-4-amine
-
N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine
-
N2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl]-N4-(quinolin-5-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
NU6027
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents non-specific inhibitor for ATR
NVP-BEZ235
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents non-specific inhibitor for ATR
PF-3758309
-
-
PF670462
a CK1delta/epsilon kinase inhibitor
PHA-767491
-
nanomolar, ATP-competitive, Cdc7 inhibitor
PIK-75
a p110alpha-selective PI3K inhibitor
purvalanol
-
inhibition of AMPK, slight inhibition of GSK3beta and S6K1, PKBalpha
Ro 31-8220
-
roscovitine
-
slight inhibition of PKBalpha and MAPKAP-K2
SB203580
slight inhibition of the protein kinase
staurosporine
Su-11248
-
-
TAACS
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
TAALD
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
TAALE
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
TBCA
-
-
Torin 2
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents non-specific inhibitor for ATR
-
VE-821
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents, blocks activation of Chk1-dependent signaling pathway, enhances DNA damage in combination with cisplatin, arrests cell cycle in G2/M phase
-
VE-822
ATR inhibition sensitizes cancer cells to ionizing radiation and chemotherapeutics agents (cisplatin, oxaliplatin, gemcitabine, etoposide and SN38, the active metabolite of irinotecan)
Wortmannin
YM024
a p110alpha-selective PI3K inhibitor
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5'-AMP
arachidonic acid
-
activates in vitro, binds at the autoinhibitory site at the C-terminal C2-domain
cardiolipin
-
activates isozyme PKNalpha
cytokine
physiological concentrations of cytokine in the picomolar range were sufficient for activating the protein kinase activity of PI3K leading to Ser585 phosphorylation and hemopoietic cell survival but did not activate PI3K lipid kinase signaling or promote proliferation
-
fatty acids
-
activate PKN1
FRAT-2
-
i.e. frequently rearranged in advanced T-cell lymphoma protein 2, activates phosphorylation of primed sites of tau protein about 8fold, no effect on unprimed site phosphorylation
-
gastrin
-
bind to the cysteine-rich domain C1b, activates, triggers nuclear accumulation of PPKD2 in AGS-B cancer cells
Insulin
-
kenpaullone
-
slight activation of S6K1
linoleic acid
-
-
lysophosphatidic acid
-
activates isozyme PKNalpha
lysophosphatidylinositol
-
activates isozyme PKNalpha
PDK1 interacting fragment PIF
required for activity of PDK1
-
pervanadate
activation of Akt is associated with tyrosine phosphorylation of Akt
Phorbol esters
-
bind to the cysteine-rich domain C1b
phosphatidylinositol 3,4,5-trisphosphate
phosphatidylinositol 4,5-bisphosphate
-
activates isozyme PKNalpha
pyrvinium
-
an FDA-approved anthelmintic drug, a very potent allosteric activator of CKalpha that inhibits the Wnt/beta-catenin pathway by increasing phosphorylation and degradation of beta-catenin, along with other key substrates. it is specific for CK1alpha versus other forms of CK1
Rho
-
activates PKN1
-
RhoA
-
small GTPase, binds to the ACC domain and activates isozymes PKNalpha and PRK2/PKNgamma/PAK-2
serum
activation of Akt is associated with tyrosine phosphorylation of Akt
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0048 - 0.134
ATP
0.0093
Lys-Lys-Phe-Asn-Arg-Thr-Leu-Ser-Val-Ala
-
0.0036 - 0.0037
RRRLSSLRA
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.057 - 0.19
ATP
0.057 - 0.19
RRRLSSLRA
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00017
(5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid
-
-
0.00004
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole
-
-
0.0004
4,5,6,7-tetrabromo-1H-benzotriazole
-
-
0.0007
4,5,6,7-tetrabromobenzimidazole
-
-
0.00074
apigenin
-
-
0.00008
benzene 1,2,3,4-tetrakisphosphate
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate
0.00022
benzene 1,2,3,5-tetrakisphosphate
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate
0.00059
benzene 1,2,3-trisphosphate
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate
0.00011
benzene 1,2,4,5-tetrakisphosphate
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate
0.00061
benzene 1,2,4-trisphosphate
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate
0.00218
benzene 1,3,5-trisphosphate
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate
0.000027
biphenyl 2,3',4,5',6-pentakisphosphate
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate
0.00012
D-myo-Inositol 1,3,4,5-tetrakisphosphate
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate
0.00023
diC8-phosphatidylinositol 3,4,5-trisphosphate
-
values for inhibition at the PH-domain of PKBalpha are obtained using competition with biotinylated diC8-phosphatidylinositol 3,4-bisphosphate
0.0045
DRB
-
-
0.00002
ellagic acid
-
-
0.00185
emodin
-
-
0.000015 - 0.000039
PF-3758309
-
0.000077
TBCA
-
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00039
(5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid
Homo sapiens
-
-
0.000002
(S)-2-(2-aminopyrimidiny-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridinione
Homo sapiens
-
-
0.062
1,1'-[(5-chloropyrimidine-2,4-diyl)bis[azanediyl(3-methoxy-4,1-phenylene)piperazine-4,1-diyl]]di(ethan-1-one)
Homo sapiens
pH and temperature not specified in the publication
0.0048
1-(6-[[4-(2,3-dihydro-1H-indol-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-5-methoxy-2,3-dihydro-1H-indol-1-yl)-2-(dimethylamino)ethan-1-one
Homo sapiens
pH and temperature not specified in the publication
0.000058
1-[3-methoxy-4-([6-[2-(propane-2-sulfonyl)anilino]-7H-purin-2-yl]amino)phenyl]piperidin-4-ol
Homo sapiens
pH and temperature not specified in the publication
0.00015
2,3-difluoro-6-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
Homo sapiens
pH and temperature not specified in the publication
0.000007
2-(2-aminopyrimidin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
Homo sapiens
-
-
0.000031
2-([5-bromo-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.000066
2-([5-chloro-2-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.000037
2-([5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.0076
2-([5-chloro-2-[2-methoxy-4-(morpholin-4-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.000963
2-([5-chloro-2-[4-(piperazin-1-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.000006
2-chloro-N-(4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)phenyl)benzamide
Homo sapiens
wild type Aurora A kinase
0.00014
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole
Homo sapiens
-
-
0.006
2-fluoro-6-([2-[(5-methoxy-1-[[4-(propan-2-yl)piperazin-1-yl]acetyl]-2,3-dihydro-1H-indol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0021
2-fluoro-6-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.000003
2-phenyl-5-(pyridin-4-yl)-1H-pyrrole-3-carboxamide
Homo sapiens
-
-
0.0013
2-[(2-[4-chloro-2-methoxy-5-[(1-propylpiperidin-4-yl)oxy]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
Homo sapiens
pH and temperature not specified in the publication
0.014
2-[(2-[5-[(N,N-dimethylglycyl)(methyl)amino]-2-methoxy-4-methylanilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
Homo sapiens
pH and temperature not specified in the publication
0.00028
2-[(2-[5-[(N,N-dimethylglycyl)amino]-2-methoxy-4-methylanilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
Homo sapiens
pH and temperature not specified in the publication
0.0013
2-[(2-[[1-(N,N-dimethylglycyl)-5-methoxy-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-N-methylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.0001
3,8-dibromo-7-hydroxy-4-methyl-2H-chromen-2-one
Homo sapiens
-
-
0.000247
3-[(2-[[1-(N,N-dimethylglycyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methylpyridine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000047
3-[(2-[[1-(N,N-dimethylglycyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]thiophene-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000022
3-[(2-[[1-(N,N-dimethylglycyl)-6-methoxy-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]thiophene-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.001922 - 0.002671
3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate
0.0005
4,5,6,7-tetrabromo-1H-benzotriazole
Homo sapiens
-
-
0.000044 - 0.0028
4-(2-(4-(2-(4-acetylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)-N-(2-chlorophenyl)benzamide
0.00025
4-fluoro-2-([2-[2-methoxy-4-(1-propylpiperidin-3-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.000107
4-fluoro-2-([2-[2-methoxy-4-(1-propylpiperidin-4-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00008
5-chloro-N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.00023
5-chloro-N2-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-N4-[2-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.00061
5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.00051
5-chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.000072
5-fluoro-2-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00013
5-fluoro-N2,N4-bis(4-methoxyphenyl)pyrimidine-2,4-diamine
Homo sapiens
wild type Aurora A kinase
0.00068
5-fluoro-N2,N4-di(m-tolyl)pyrimidine-2,4-diamine
Homo sapiens
wild type Aurora A kinase
0.0016
6,7-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)quinazolin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000005
6-(3-chlorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(1H)-one
Homo sapiens
-
-
0.0003
8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one
Homo sapiens
-
-
0.0008
apigenin
Homo sapiens
-
-
0.000074
AZD-6738
Homo sapiens
pH and temperature not specified in the publication
-
0.00014
DMAT
Homo sapiens
-
-
0.013
DRB
Homo sapiens
-
-
0.00004
ellagic acid
Homo sapiens
-
-
0.002
emodin
Homo sapiens
-
-
0.0004
GSK2606414
Homo sapiens
pH and temperature not specified in the publication
-
0.0009
GSK2656157
Homo sapiens
pH and temperature not specified in the publication
-
0.0018
harmine
Homo sapiens
pH and temperature not specified in the publication
0.000019
idelalisib
Homo sapiens
pH 7.4, 25°C, recombinant enzyme
0.00039
IQA
Homo sapiens
-
-
0.000022 - 0.00004
JAK3 inhibitor VI
0.0000028 - 0.0000036
K252a
0.000001
MLN8054
Homo sapiens
wild type Aurora A kinase
0.000026 - 0.002
N-(2-chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
0.00001
N-(2-chlorophenyl)-4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)benzamide
Homo sapiens
wild type Aurora A kinase
0.000054
N-cyclopropyl-4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)benzamide
Homo sapiens
wild type Aurora A kinase
0.001
N-ethyl-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-3a,6a-dihydro-1H-thieno[3,2-c]pyrazole-5-carboxamide
Homo sapiens
-
IC50 less than 0.001 mM
0.0062
N-tert-butyl-3-([5-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino)benzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.0012
N-[(2R)-2,3-dihydroxypropyl]-5-fluoro-2-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00075
N-[2-([5-chloro-2-[2-methoxy-4-(morpholin-4-yl)anilino]pyrimidin-4-yl]amino)phenyl]methanesulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.013
N-[2-([5-fluoro-2-[2-methoxy-4-(morpholin-4-yl)anilino]pyrimidin-4-yl]amino)phenyl]methanesulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.015
N-[3-([2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino)phenyl]prop-2-enamide
Homo sapiens
pH and temperature not specified in the publication
0.00069
N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
Homo sapiens
pH and temperature not specified in the publication
0.0014
N-[5-(4-fluorophenyl)-1H-pyrazol-3-yl]-6,7-dimethoxyquinazolin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0038
N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.0015
N2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl]-N4-(quinolin-5-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.00001
PHA-767491
Homo sapiens
-
-
0.0000018 - 0.000002
staurosporine
0.000015 - 0.000026
Su-11248
0.0005
TBB
Homo sapiens
-
-
0.0005
TBBz
Homo sapiens
-
-
0.00011
TBCA
Homo sapiens
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.25
-
specific activity of an N-terminal His6 affinity tagged catalytic kinase domain construct of the alphaII isoform of S6K1 lacking the autoinhibitory domain (AID) (DELTA399-502/T389E)
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
assay at
7.2
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
21
-
assay at room temperature
25
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.51
sequence calculation
9.1
amino acid sequence calculation
additional information
-
CK1 family members are generally positively charged, with isoelectric points above 9
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
lymphoid cell line, specific expression of isozyme PRK2/PKNgamma/PAK-2
Manually annotated by BRENDA team
moderate ULK3 expression level
Manually annotated by BRENDA team
leukemia cell line, cells undergo terminal differentiation after treatment with phorbol ester, hBub1 expression in this cell line is down-regulated rapidly
Manually annotated by BRENDA team
-
U251, T98, U87, U373, U118, A172
Manually annotated by BRENDA team
-
isozyme PRK2/PKNgamma/PAK-2
Manually annotated by BRENDA team
-
chromic myelogenous leukemia cell line, isozyme PKNbeta
Manually annotated by BRENDA team
primary human acute myeloid leukemia (AML) cells
Manually annotated by BRENDA team
-
melanoma cell line
Manually annotated by BRENDA team
-
interleukin-6 and TNF family cytokines, TNFalpha, BAFF and APRIL, but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in multiple myeloma cells
Manually annotated by BRENDA team
low ULK3 expression level
Manually annotated by BRENDA team
-
overexpression in malignant prostate glandular cells
Manually annotated by BRENDA team
telomerase reverse transcriptase immortalized retinal pigmented epithelial cells
Manually annotated by BRENDA team
-
neuroblastoma cell line
Manually annotated by BRENDA team
low ULK3 expression level
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
the enzyme subunits are recruited to the cell membrane following activation of receptor tyrosine kinases and G protein-coupled receptors
-
Manually annotated by BRENDA team
-
isozyme PKNalpha
Manually annotated by BRENDA team
-
isozyme PKNalpha
Manually annotated by BRENDA team
coexpression of PAK4 and the constitutively active Cdc42HsV12 causes the redistribution of PAK4 to the brefeldin A-sensitive compartment of the Golgi membrane and the subsequent induction of filopodia and actin polymerization
Manually annotated by BRENDA team
-
HIPK2 colocalizes with Daxx in promyelotic leukemia nuclear bodies
Manually annotated by BRENDA team
-
isozyme PKNbeta
-
Manually annotated by BRENDA team
-
isozyme PKNalpha
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug target
evolution
malfunction
metabolism
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TITIN_HUMAN
34350
0
3816030
Swiss-Prot
Secretory Pathway (Reliability: 5)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
204000
-
SDS-PAGE
47300
x * 47300, calculation from nucleotide sequence
52600
x * 52600, about, sequence calculation, x * 53000, in vitro expressed enzyme, SDS-PAGE, x * 60000, about, enzyme expressed in Caco-2-BBE cells, SDS-PAGE
53000
x * 52600, about, sequence calculation, x * 53000, in vitro expressed enzyme, SDS-PAGE, x * 60000, about, enzyme expressed in Caco-2-BBE cells, SDS-PAGE
60000
x * 52600, about, sequence calculation, x * 53000, in vitro expressed enzyme, SDS-PAGE, x * 60000, about, enzyme expressed in Caco-2-BBE cells, SDS-PAGE
64000
x * 64000, calculation from nucleotide sequence
70000
x * 70000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterodimer
1 * 110000, p110 subunit, + 1 * 85000, p85 subunit
monomer
-
-
tetramer
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
proteolytic modification
-
PKNalpha is cleaved by caspase-3 or related proteases in apoptotic Jurkat and U-937 cells contributing to signal transduction
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
microbatch-under-oil method, using 100 mM Bis-Tris (pH 6.5), 28% (w/v) PEG 2000
purified enzyme mutant, mixing of 25 nl 11 mg/ml protein with 0.9 mM inhibitor delalisib in 20 mM Tris, pH 7.2, 50 mM (NH4)2SO4, 1% v/v ethylene glycol, 1% w/v betaine, 300 mM CHAPS, and 5 mM TCEP, with 25 nl of reservoir solution containing 25% w/v PEG 3350, 0.1 M Bis-Tris, pH 6.5, microseeding in 480 nl of 2.5% w/v n-dodecyl-beta-D-maltoside, 300 nl of 20 mM ligand, and 0.12 ml of 12 mg/ml DELTAABD-p110delta in storage buffer 20 mM Tris, pH 7.2, 50 mM (NH4)2SO4, 1% v/v ethylene glycol, 1% w/v betaine, 300 nM CHAPS, and 5mM TCEP, X-ray diffraction structure determination and analysis at 2.4-2.5 A resolution
purified recombinant Leu-Glu-His6-tagged GSK3beta in complex with ATP or ATP analogue AMP-PNP, 10 mg/ml protein, 2 mM ATP or AMP-PNP, 12-14% w/v PEG 6000, 100 mM NaCl, 5 mM MgCl2, 10% v/v glycerol, in 100 mM HEPES-NaOH, pH 7.5, hanging drop vapor diffusion method, 4°C, several days, soaking in 0.1 mM ethylmercuric thiosalyclate at pH 7.5 for 1 h, cryoprotection by 30% w/v D-sorbitol, X-ray diffraction structure determination and analysis at 1.7-2.6 A resolution
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D1994A
-
kinase-dead mutant
DELTA1-398
the autoinhibitory domain is separately expressed and purified. Trans-addition of purified AID effectively inhibits PDK1-catalyzed T-loop phosphorylation of a catalytic kinase domain construct of S6K1
DELTA1-398/S411D/S418D/T421E/S424D
expression of the autoinhibitory domain with several mutations shows that the tetraphospho-mimicking mutations in the autoinhibitory domain construct significantly decreased AID-mediated inhibition of PDK1-catalyzed T229 phosphorylation of DELTA399-502/T389E (His6-S6K1(DELTA AID)-T389E)
DELTA399-502/T389E
E545K
site-directed mutagenesis
G2019S
-
the mutation results in a robust enhancement of LRRK2 activity with peptide LRRKtide as the substrate, the mutation also affects binding of ATP to LRRK2 with wild type binding being tighter
I112V
-
the mutant shows increased activity compared to the wild type enzyme
I119A
site-directed mutagenesis of a PIF pocket residue of PDK1, mutant shows reduced activity compared to the wild-type enzyme
I2020T
-
the mutant shows reduced activity compared to the wild type enzyme
I34L
site-directed mutagenesis, inactive mutant of the intestinal inflammation-associated colonic epithelial isozyme
K118A
kinase-inactive mutant does not inhibit MEKK1 and only weakly inhibits MEKK2 autophosphorylation
K139R
site-directed mutagenesis, the mutant is defective in autophosphorylation
K221A
-
site-directed mutagenesis of HIPK2, mutant shows reduced interaction and colocalization with Daxx
K41M
site-directed mutagenesis, inactive mutant, no interaction with heat shock proteins
K44R
site-directed mutagenesis, the mutant is defective in autophosphorylation
K46R
-
site-directed mutagenesis, inactive, dominant negative mutants of CK1alpha, overexpression in SH-SY5Y cells does not influence endogenous basal and metacholine-stimulated M3 muscarinic acetylcholine receptor phosphorylation and desensitization by the endogenous wild-type GRK6
K644E
-
site-directed mutagenesis, inactive mutant, PKN1 depletion causes an increase in NF-kappaB-dependent reporter gene expression
K802R
site-directed mutagenesis
K96R
-
the mutant is less sensitive to inhibition by 4-hydroxy-trans-2-nonenal compared to the wild-type
K96R/K97R
-
the mutant is less sensitive to inhibition by 4-hydroxy-trans-2-nonenal compared to the wild-type and to a greater extent than the single point mutants K96R and K97R
K97R
-
the mutant is less sensitive to inhibition by 4-hydroxy-trans-2-nonenal compared to the wild-type
M24L
mutation in the alpha I polypeptide suppresses synthesis of the alpha II polypeptides
M24T
mutation in the alpha I polypeptide suppresses synthesis of the alpha II polypeptides
Q150A
site-directed mutagenesis of a PIF pocket residue of PDK1, mutant shows reduced activity compared to the wild-type enzyme
R1441C
-
the mutant shows increased activity compared to the wild type enzyme
R96A
-
site-directed mutagenesis of GSK3beta, the mutant shows reduced phosphorylation activity at primed epitopes and increased activity at unprimed epitopes of tau protein substrate compared to the wild-type GSK3beta
S281A
-
site-directed mutagenesis, mutant shows abolished autophosphorylation at T444
S47D
the mutant enzyme inhibits cell migration and promotes cell proliferation
S9A
-
site-directed mutagenesis, mutant cannot be inhibited by phosphorylation at position 9 and is thus constitutively active
T217E
the mutant has very similar activity as the wild type enzyme
T444A
-
site-directed mutagenesis, mutant shows almost unaltered autophosphorylation at S281 compared to the wild-type enzyme
T474F
55% inhibition of Akt activation
T508V
activity is abolished
T74A
-
site-directed mutagenesis, mutant shows only slightly reduced kinase activity and autophosphorylation compared to the wild-type enzyme
V66A/I174A
-
site-directed mutagenesis, an engineered TBB inhibitor-resistant CK2 mutant CK2alpha'R
V67A/I175A
-
site-directed mutagenesis, an inhibitor-resistant CK2 mutant CK2alpha'R
Y1699C
-
the mutant shows increased activity compared to the wild type enzyme
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
an N-terminal His6 affinity tagged catalytic kinase domain construct of the alphaII isoform of S6K1 lacking the autoinhibitory domain (AID) (His6-S6K1alphaII(DELTA AID)-T389E), is expressed in Escherichia coli and purified by His6 affinity co-purification and by MonoQ anion exchange chromatography at pH 7.3
-
FLAG immunoaffinity column chromatography
-
mutant enzymes are purified by anti-Flag M2 agarose column chromatography and Superdex S-200 gel filtration
optimal bacterial expression and affinity purification of the full autoinhibitory domain (AID) of S6K1 is achieved by fusing GST to the N-terminus, growing the BL21 (DE3) strain of Escherichia coli in PG minimal medium, adding the irreversible protease inhibitors TPCK and TLCK to the lysis buffer, using the highly selective PreScission Protease to remove the GST affinity tag, and using the Superdex 75 size-exclusion column to resolve cleaved full length AID from smaller proteolyzed fragments
recombinant CK2 from insect Sf9 cells to homogeneity
-
recombinant GB1-tagged FATC domain, hDNAPKfatc, from Escherichia coli strain BL21(DE3) by immunoaffinity chromatography, tag cleavage
recombinant GST-fusion TSSK5 from HEK-293 cells by glutathione affinity chromatography
recombinant His6-tagged wild-type full-length PI3Kgamma isozyme from Spodoptera frugiperda Sf9 cells by nickel affinity chromatography
recombinant isolated GB1-fusion ATM FATC domain from Escherichia coli strain BL21(DE3) by immunoaffinity chromatography, tag cleavage
recombinant Leu-Glu-His6-tagged GSK3beta from Escherichia coli
-
recombinant N-terminally FLAG-tagged wild-type and mutant enzymes from HEK-293 cells by immunoaffinity precipitation
recombinant N-terminally His6-tagged p110 and nontagged p85 subunits from Spodoptera frugiperda Sf21 cells by nickel affinity chromatography
recombinant wild-type and mutant GST-fusion NDR1 from Escherichia coli strain BL21(DE3) by glutathione affinity chromatography
-
recombinant wild-type and mutant GST-tagged LBK1s from HEK-293T cells by immunoprecipitation
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
characterization of the gene
cloning and recombinant expression of the isolated ATM FATC domain in Escherichia coli strain BL21(DE3) fused to the B1 domain of protein G, GB1
cloning and recombinant expression of the isolated FATC domain, hDNAPKfatc, in Escherichia coli strain BL21(DE3) as GB1 fusion protein
co-expression of Akt and hSWI/SNF proteins in Spodoptera frugiperda Sf9 cells using the baculovirus infection system, complex formation between the enzyme and the substrate proteins occurs, overview
-
coexpression of N-terminally His6-tagged p110 and nontagged p85 subunits in Spodoptera frugiperda Sf21 cells via baculovirus transfection method, recombinant expression of DELTAABC mutant p110delta with the iSH2 domain of p85alpha
determination of genomic structure
DNA and amino acid sequence determination and analysis of TSSK5, expression of His-tagged CREB in Escherichia coli, expression of GST-fusion TSSK5 in HEK-293 cells, co-expression of TSSK5 and CREB in Saccharomyces cerevisiae using the two-hydrid system
DNA and amino acid sequence determination and analysis, in vitro transcription and translation, overexpression of the SPAK isozyme in Caco-2-BBE cells
DNA sequence determination of isozyme PKNbeta
-
expresion of wild-type and mutant GST-fusion NDR1 in Escherichia coli strain BL21(DE3), expression of HA-tagged NDR1 in COS-1 cells
-
expressed in baculovirus-infected insect cells
-
expressed in COS7 cells
expressed in Escherichia coli BL21(DE3)-Gold and Tuner(DE3) cells
expressed in Mus musculus
-
expressed in Neuro2a cells
-
expression in COS cells
expression in Cos-1 cells
expression in Sf9 cells
expression of CK2 alpha and beta subunits in Spodoptera frugiperda Sf9 cells via baculovirus transfection system
-
expression of EGFP- or FLAG-tagged wild-type or domain-deletion mutants of PKD2 in HEK-293 cells, gastric cancer AGS-B cells, and in PANC-1 cells
-
expression of FLAG-tagged full-length PKN1 and of its isolated catalytic kinase domain, residues 561-942, in CHO-K1 cells, co-expression with Salmonella enterica SspH1, SspH2, YopM and IpaH9.8, all HA-tagged, in HeLa cells, interaction study, overview
-
expression of GSK3beta in Escherichia coli in fusion with a Leu-Glu-His6-tag at the C-terminus
-
expression of His-tagged CK2 in Escherichia coli strain BL21
-
expression of subunits CK2alpha and CK2beta, and of the CK2 holoenzyme in Escherichia coli, expression of Myc-tagged CK2beta in GV10.15 cells, expression of the human Drosophila homologue CK2·-Timekeeper
-
expression of wild-type and mutant GST-tagged LBK1s in HEK-293T cells
-
gene PIM1, recombinant overexpression in enzyme-deficient trangenic Pim1-Tx Mus musculus driven by vav hematopoietic promoter/regulatory elements. Compared to wild-type littermates, Pim1-Tx mice show enhanced hematopoiesis as demonstrated by increased numbers of Lin-Sca-1+c-Kit+ (LSK) hematopoietic stem/progenitor cells and cobblestone area forming cells, higher BrdU incorporation in long-term hematopoietic stem cell population, and a better ability to reconstitute lethally irradiated mice. Pim1-Tx mice express human PIM1 mRNA in all hematopoietic tissues including spleen, bone marrow and thymus, but not in non-hematopoietic tissues such as kidney
gene STK38, recombinant expression in HeLa cells
gene transcript organization of human CK1 isoforms and their splice variants, overview
-
gene ULK3, DNA and amino acid sequence determination and analysis, sequence comparisons, expression of N-terminally FLAG-tagged wild-type and mutant enzymes in HEK-293 cells
genomic intron-exon structure of the human BUB1 gene
identification of cDNA
intronless gene
isolation and characterization of cDNA
isolation of cDNA
microinjection of activated Pak1 protein into quiescent Swiss 3T3 cells
mutant enzymes are expressed in Escherichia coli BL21-DE3 pLysS-Rosetta cells
overexpression of wild-type and mutant FLAG-tagged HIPK2 in 293T cells, coexpression of wild-type and mutant HIPK2 with HA-tagged JNK1 in 293 cells
-
recombinant expression of His6-tagged wild-type full-length PI3Kgamma isozyme in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method
recombinant expression of wild-type and mutant enzymes in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method
SSTK gene, DNA and amino acid sequence determination and analysis, transient expression of wild-type and mutant Myc-tagged SSTK in 293T cells
stable 20fold overexpression of K46R mutant CK1alpha in SH-SY5Y neuroblastoma cells via adenovirus infection system
-
targeted overexpression of both CK2 and either c-Myc or Tal-1 in T-cells, as well as in tumor suppressor p53 (-/-) mice or murine BALB/c 3T3 fibroblasts
-
the PH domain of PKBalpha (amino acids 1-123) is subcloned into the BamH1 restriction site of the Escherichia coli expression vector pGEX2T
-
transient co-expression of human tau long isoform, HA-tagged GSK3beta, and GST-tagged GFP-fusion FRAT-2 protein in HEK-293 cells
-
transient expression of CKII alpha and beta subunits in human U87 astroglioma cells
-
transient expression of HA-tagged wild-type and mutant enzymes in CHO cells
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after norepinephrine administration, caseine kinase 2 (CK2), is induced and more active in primary white adipocytes compared to both brown and beige adipocytes. CK2 activity is induced in the inguinal white adipose tissue depot after high-fat feeding. This increase in CK2 activity is selective for white adipose tissue since no change in CK2 activity is found in brown adipose tissue
-
baicalin, one of the major compounds in the Chinese medical herb Scutellaria baicalensis, reduces enzyme expression and activity in badder cancer cells T24
-
enzyme activity is stimulated by oxidative stresses such as hydrogen peroxide and X-ray irradiation
enzyme expression is frequently up-regulated in CRC clinical samples at the protein levels and significantly associated with tumor differentiation grade, lymph node metastasis, TNM stage, and patient death
-
interleukin-6 and TNF family cytokines, TNFalpha, BAFF and APRIL, but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in multiple myeloma cells. Interleukin-6 and TNF family cytokines cooperatively enhance Pim-2 expression. Cucurbitacin I suppresses the Pim-2 upregulation by interleukin-6. Pim-2 upregulation by TNFalpha is suppressed by parthenolide. STAT3 and NF-kappaB activation mediates Pim-2 upregulation in mutiple myeloma cells
-
overexpression of microRNA miR-455 decreases protein expression of RAF proto-oncogene serine/threonine-protein kinase (RAF1) but has no effect on mRNA level. miR-455 regulates RAF1 expression directly. Overexpression of miR-455 significantly inhibits the proliferation and the invasion of SW480, but has no effect on apoptosis. Overexpression of RAF1 partially reverses the inhibitory effect of miR-455 on the growth and the invasion of SW480
-
overexpression of miR-455 decreases protein expression of RAF proto-oncogene serine/threonine-protein kinase RAF1 but has no effect on mRNA level
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
medicine
molecular biology
STK38 interacts with the MAPKKKs MEKK1 and MEKK2 (MEKK1/2). STK38 inhibits MEKK1/2 activation without preventing MEKK1/2 binding to its substrate, SEK1. STK38 suppresses the autophosphorylation of MEKK2 without interfering with MEKK2 dimer formation, and converts MEKK2 from its phosphorylated to its nonphosphorylated form. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2, suggesting a novel mechanism of MEKK1/2 regulation
pharmacology
-
CK2 is a potential therapeutic target and a target for inhibitor design, e.g. in anti-cancer therapy
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (O15530), Schizosaccharomyces pombe (Q12701)
Manually annotated by BRENDA team
Deloukas, P.; Matthews, L.H.; Ashurst, J.; Burton, J.; Gilbert, J.G.; et al.
The DNA sequence and comparative analysis of human chromosome 20
Nature
414
865-871
2001
Homo sapiens (P68400), Homo sapiens (Q96S44), Homo sapiens (Q9P286)
Manually annotated by BRENDA team
Edwards, D.C.; Gill, G.N.
Structural features of LIM kinase that control effects on the actin cytoskeleton
J. Biol. Chem.
274
11352-11361
1999
Homo sapiens (P53667)
Manually annotated by BRENDA team
Frangiskakis, J.M.; Ewart, A.K.; Morris, C.A.; Mervis, C.B.; Bertrand, J.; Robinson, B.F.; Klein, B.P.; Ensing, G.J.; Everett, L.A.; Green, E.D.; Proschel, C.; Gutowski, N.J.; Noble, M.; Atkinson, D.L.; Odelberg, S.J.; Keating, M.T.
LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition
Cell
86
59-69
1996
Homo sapiens (P53667)
Manually annotated by BRENDA team
Mizuno, K.; Okano, I.; Ohashi, K.; Nunoue, K.; Kuma, K.; Miyata, T.; Nakamura, T.
Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif
Oncogene
9
1605-1612
1994
Homo sapiens (P53667)
Manually annotated by BRENDA team
Osborne, L.R.; Martindale, D.; Scherer, S.W.; Shi, X.M.; Huizenga, J.; Heng, H.H.; Costa, T.; Pober, B.; Lew, L.; Brinkman, J.; Rommens, J.; Koop, B.; Tsui, L.C.
Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients
Genomics
36
328-336
1996
Homo sapiens (P53667)
Manually annotated by BRENDA team
Dunham, I.; Shimizu, N.; Roe, B.A.; Chissoe, S.; Hunt, A.R.; Collins, J.E.; Bruskiewich, R.; Beare, D.M.; Clamp, M.; Smink, L.J.; Ainscough, R.; Almeida, J.P.; Babbage, A.; Bagguley, C.; Bailey, J.; Barlow, K.; Bates, K.N.; Beasley, O.; Bird, C.P.; Blakey, S.; Bridgeman, A.M.; Buck, D.; Burgess, J.; Burrill, W.D.; O'Brien, K.P.; et al.
The DNA sequence of human chromosome 22
Nature
402
489-495
1999
Homo sapiens (O96017), Homo sapiens (P49674)
Manually annotated by BRENDA team
Gamper, N.; Fillon, S.; Feng, Y.; Friedrich, B.; Lang, P.A.; Henke, G.; Huber, S.M.; Kobayashi, T.; Cohen, P.; Lang, F.
K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK
Pflugers Arch.
445
60-66
2002
Homo sapiens (O00141), Homo sapiens
Manually annotated by BRENDA team
Conus, N.M.; Hannan, K.M.; Cristiano, B.E.; Hemmings, B.A.; Pearson, R.B.
Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase
J. Biol. Chem.
277
38021-38028
2002
Homo sapiens (P31749)
Manually annotated by BRENDA team
Wiemann, S.; Weil, B.; Wellenreuther, R.; et al
Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs
Genome Res.
11
422-435
2001
Homo sapiens (Q9Y243)
Manually annotated by BRENDA team
Matsubara, A.; Wasson, J.C.; Donelan, S.S.; Welling, C.M.; Glaser, B.; Permutt, M.A.
Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes
Diabetologia
44
910-913
2001
Homo sapiens (P31749), Homo sapiens
Manually annotated by BRENDA team
Brunet, A.; Park, J.; Tran, H.; Hu, L.S.; Hemmings, B.A.; Greenberg, M.E.
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
Mol. Cell. Biol.
21
952-965
2001
Homo sapiens (O00141)
Manually annotated by BRENDA team
Lang, F.; Klingel, K.; Wagner, C.A.; et al
Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy
Proc. Natl. Acad. Sci. USA
97
8157-8162
2000
Homo sapiens (O00141)
Manually annotated by BRENDA team
Kobayashi, T.; Cohen, P.
Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
Biochem. J.
339
319-328
1999
Homo sapiens (O00141)
-
Manually annotated by BRENDA team
Kobayashi, T.; Deak, M.; Morrice, N.; Cohen, P.
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase
Biochem. J.
344
189-197
1999
Homo sapiens (O00141)
-
Manually annotated by BRENDA team
Waldegger, S.; Erdel, M.; Nagl, U.O.; Barth, P.; Raber, G.; Steuer, S.; Utermann, G.; Paulmichl, M.; Lang, F.
Genomic organization and chromosomal localization of the human SGK protein kinase gene
Genomics
51
299-302
1998
Homo sapiens (O00141), Homo sapiens
Manually annotated by BRENDA team
Waldegger, S.; Barth, P.; Raber, G.; Lang, F.
Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume
Proc. Natl. Acad. Sci. USA
94
4440-4445
1997
Homo sapiens (O00141), Homo sapiens
Manually annotated by BRENDA team
Delcommenne, M.; Tan, C.; Gray, V.; Rue, L.; Woodgett, J.; Dedhar, S.
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
Proc. Natl. Acad. Sci. USA
95
11211-11216
1998
Homo sapiens (P31749)
Manually annotated by BRENDA team
Alessi, D.R.; Andjelkovic, M.; Caudwell, B.; Cron, P.; Morrice, N.; Cohen, P.; Hemmings, B.A.
Mechanism of activation of protein kinase B by insulin and IGF-1
EMBO J.
15
6541-6551
1996
Homo sapiens (P31749)
Manually annotated by BRENDA team
Coffer, P.J.; Woodgett, J.R.
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
Eur. J. Biochem.
205
1217
1992
Homo sapiens (P31749), Bos taurus (Q01314)
Manually annotated by BRENDA team
Jones, P.F.; Jakubowicz, T.; Pitossi, F.J.; Maurer, F.; Hemmings, B.A.
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
Proc. Natl. Acad. Sci. USA
88
4171-4175
1991
Homo sapiens (P31749), Homo sapiens
Manually annotated by BRENDA team
Coffer, P.J.; Woodgett, J.R.
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
Eur. J. Biochem.
201
475-481
1991
Homo sapiens (P31749), Homo sapiens, Bos taurus (Q01314), Bos taurus
Manually annotated by BRENDA team
Brodbeck, D.; Hill, M.M.; Hemmings, B.A.
Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain
J. Biol. Chem.
276
29550-29558
2001
Mus musculus (Q9WUA6), Mus musculus, Homo sapiens (Q9Y243), Homo sapiens
Manually annotated by BRENDA team
Nakatani, K.; Sakaue, H.; Thompson, D.A.; Weigel, R.J.; Roth, R.A.
Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site
Biochem. Biophys. Res. Commun.
257
906-910
1999
Homo sapiens (Q9Y243), Homo sapiens
Manually annotated by BRENDA team
Masure, S.; Haefner, B.; Wesselink, J.J.; Hoefnagel, E.; Mortier, E.; Verhasselt, P.; Tuytelaars, A.; Gordon, R.; Richardson, A.
Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3
Eur. J. Biochem.
265
353-360
1999
Homo sapiens (Q9Y243), Homo sapiens
Manually annotated by BRENDA team
Brodbeck, D.; Cron, P.; Hemmings, B.A.
A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
J. Biol. Chem.
274
9133-9136
1999
Mus musculus (Q9WUA6), Mus musculus, Homo sapiens (Q9Y243), Homo sapiens
Manually annotated by BRENDA team
Grove, J.R.; Banerjee, P.; Balasubramanyam, A.; Coffer, P.J.; Price, D.J.; Avruch, J.; Woodgett, J.R.
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini
Mol. Cell. Biol.
11
5541-5550
1991
Homo sapiens (P23443), Homo sapiens
Manually annotated by BRENDA team
Cheng, J.Q.; Godwin, A.K.; Bellacosa, A.; Taguchi, T.; Franke, T.F.; Hamilton, T.C.; Tsichlis, P.N.; Testa, J.R.
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
Proc. Natl. Acad. Sci. USA
89
9267-9271
1992
Homo sapiens (P31751)
Manually annotated by BRENDA team
Jones, P.F.; Jakubowicz, T.; Hemmings, B.A.
Molecular cloning of a second form of rac protein kinase
Cell Regul.
2
1001-1009
1991
Homo sapiens (P31751), Homo sapiens
Manually annotated by BRENDA team
Abidi, F.; Jacquot, S.; Lassiter, C.; Trivier, E.; Hanauer, A.; Schwartz, C.E.
Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome (CLS)
Eur. J. Hum. Genet.
7
20-26
1999
Homo sapiens (P51812), Homo sapiens
Manually annotated by BRENDA team
Jacquot, S.; Merienne, K.; De Cesare, D.; Pannetier, S.; Mandel, J.L.; Sassone-Corsi, P.; Hanauer, A.
Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations
Am. J. Hum. Genet.
63
1631-1640
1998
Homo sapiens (P51812), Homo sapiens
Manually annotated by BRENDA team
Trivier, E.; De Cesare, D.; Jacquot, S.; Pannetier, S.; Zackai, E.; Young, I.; Mandel, J.L.; Sassone-Corsi, P.; Hanauer, A.
Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome
Nature
384
567-570
1996
Homo sapiens (P51812)
Manually annotated by BRENDA team
Bjorbaek, C.; Vik, T.A.; Echwald, S.M.; et al.
Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients
Diabetes
44
90-97
1995
Homo sapiens (P51812), Homo sapiens
Manually annotated by BRENDA team
Moller, D.E.; Xia, C.H.; Tang, W.; Zhu, A.X.; Jakubowski, M.
Human rsk isoforms: cloning and characterization of tissue-specific expression
Am. J. Physiol.
266
C351-359
1994
Homo sapiens (P51812), Homo sapiens (Q15349), Homo sapiens (Q15418)
Manually annotated by BRENDA team
Klink, A.; Schiebel, K.; Winkelmann, M.; et al.
The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability
Hum. Mol. Genet.
4
869-878
1995
Homo sapiens (P51817)
Manually annotated by BRENDA team
Mahadevan, M.S.; Amemiya, C.; Jansen, G.; Sabourin, L.; Baird, S.; Neville, C.E.; Wormskamp, N.; Segers, B.; Batzer, M.; Lamerdin, J.; et al.
Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene
Hum. Mol. Genet.
2
299-304
1993
Mus musculus (P54265), Mus musculus, Homo sapiens (Q09013), Homo sapiens
Manually annotated by BRENDA team
Jansen, G.; Mahadevan, M.; Amemiya, C.; Wormskamp, N.; Segers, B.; Hendriks, W.; O'Hoy, K.; Baird, S.; Sabourin, L.; Lennon, G.; et al.
Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs
Nat. Genet.
1
261-266
1992
Mus musculus (P54265), Mus musculus, Homo sapiens (Q09013), Homo sapiens
Manually annotated by BRENDA team
Gennarelli, M.; Lucarelli, M.; Zelano, G.; Pizzuti, A.; Novelli, G.; Dallapiccola, B.
Different expression of the myotonin protein kinase gene in discrete areas of human brain
Biochem. Biophys. Res. Commun.
216
489-494
1995
Homo sapiens (Q09013), Homo sapiens
Manually annotated by BRENDA team
Sasagawa, N.; Sorimachi, H.; Maruyama, K.; Arahata, K.; Ishiura, S.; Suzuki, K.
Expression of a novel human myotonin protein kinase (MtPK) cDNA clone which encodes a protein with a thymopoietin-like domain in COS cells
FEBS Lett.
351
22-26
1994
Homo sapiens (Q09013)
Manually annotated by BRENDA team
Shaw, D.J.; McCurrach, M.; Rundle, S.A.; Harley, H.G.; Crow, S.R.; Sohn, R.; Thirion, J.P.; Hamshere, M.G.; Buckler, A.J.; Harper, P.S.; et al.
Genomic organization and transcriptional units at the myotonic dystrophy locus
Genomics
18
673-679
1993
Homo sapiens (Q09013)
Manually annotated by BRENDA team
Fu, Y.H.; Friedman, D.L.; Richards, S.; Pearlman, J.A.; Gibbs, R.A.; Pizzuti, A.; Ashizawa, T.; Perryman, M.B.; Scarlato, G.; Fenwick, R.G., Jr.; et al.
Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy
Science
260
235-238
1993
Homo sapiens (Q09013)
Manually annotated by BRENDA team
Fu, Y.H.; Pizzuti, A.; Fenwick, R.G., Jr.; King, J.; Rajnarayan, S.; Dunne, P.W.; Dubel, J.; Nasser, G.A.; Ashizawa, T.; de Jong, P.; et al.
An unstable triplet repeat in a gene related to myotonic muscular dystrophy
Science
255
1256-1258
1992
Homo sapiens (Q09013)
Manually annotated by BRENDA team
Brook, J.D.; McCurrach, M.E.; Harley, H.G.; Buckler, A.J.; Church, D.; Aburatani, H.; Hunter, K.; Stanton, V.P.; Thirion, J.P.; Hudson, T.; et al.
Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member
Cell
68
799-808
1992
Homo sapiens (Q09013)
Manually annotated by BRENDA team
Zhao, Y.; Bjorbaek, C.; Weremowicz, S.; Morton, C.C.; Moller, D.E.
RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation
Mol. Cell. Biol.
15
4353-4363
1995
Homo sapiens (Q15349), Homo sapiens
Manually annotated by BRENDA team
Lee-Fruman, K.K.; Kuo, C.J.; Lippincott, J.; Terada, N.; Blenis, J.
Characterization of S6K2, a novel kinase homologous to S6K1
Oncogene
18
5108-5114
1999
Homo sapiens (Q9UBS0)
Manually annotated by BRENDA team
Saitoh, M.; ten Dijke, P.; Miyazono, K.; Ichijo, H.
Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases
Biochem. Biophys. Res. Commun.
253
470-476
1998
Homo sapiens (Q9UBS0), Homo sapiens
Manually annotated by BRENDA team
Gout, I.; Minami, T.; Hara, K.; Tsujishita, Y.; Filonenko, V.; Waterfield, M.D.; Yonezawa, K.
Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region
J. Biol. Chem.
273
30061-30064
1998
Homo sapiens (Q9UBS0)
Manually annotated by BRENDA team
Yntema, H.G.; van den Helm, B.; Kissing, J.; et al.
A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation
Genomics
62
332-343
1999
Homo sapiens (Q9UK32)
Manually annotated by BRENDA team
Brede, G.; Solheim, J.; Troen, G.; Prydz, H.
Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization
Genomics
70
82-92
2000
Homo sapiens (P11801), Homo sapiens
Manually annotated by BRENDA team
Hanks, S.K.
Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family
Proc. Natl. Acad. Sci. USA
84
388-392
1987
Homo sapiens (P11801)
Manually annotated by BRENDA team
Semba, S.; Ouyang, H.; Han, S.Y.; Kato, Y.; Horii, A.
Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium
Int. J. Oncol.
16
731-737
2000
Homo sapiens (O14757)
Manually annotated by BRENDA team
Sanchez, Y.; Wong, C.; Thoma, R.S.; Richman, R.; Wu, Z.; Piwnica-Worms, H.; Elledge, S.J.
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
Science
277
1497-1501
1997
Homo sapiens (O14757), Homo sapiens, Mus musculus (O35280)
Manually annotated by BRENDA team
Flaggs, G.; Plug, A.W.; Dunks, K.M.; Mundt, K.E.; Ford, J.C.; Quiggle, M.R.; Taylor, E.M.; Westphal, C.H.; Ashley, T.; Hoekstra, M.F.; Carr, A.M.
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
Curr. Biol.
7
977-986
1997
Homo sapiens (O14757), Mus musculus (O35280)
Manually annotated by BRENDA team
Stevenson, D.; Laverty, H.G.; Wenwieser, S.; Douglas, M.; Wilson, J.B.
Mapping and expression analysis of the human CASK gene
Mamm. Genome
11
934-937
2000
Homo sapiens (O14936)
Manually annotated by BRENDA team
Daniels, D.L.; Cohen, A.R.; Anderson, J.M.; Brunger, A.T.
Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition
Nat. Struct. Biol.
5
317-325
1998
Homo sapiens (O14936)
Manually annotated by BRENDA team
Cohen, A.R.; Woods, D.F.; Marfatia, S.M.; Walther, Z.; Chishti, A.H.; Anderson, J.M.; Wood, D.F.
Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells
J. Cell Biol.
142
129-138
1998
Homo sapiens (O14936)
Manually annotated by BRENDA team
Sossey-Alaoui, K.; Srivastava, A.K.
DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)
Genomics
56
121-126
1999
Homo sapiens (O15075), Homo sapiens
Manually annotated by BRENDA team
Matsumoto, N.; Pilz, D.T.; Ledbetter, D.H.
Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS)
Genomics
56
179-183
1999
Homo sapiens (O15075), Homo sapiens
Manually annotated by BRENDA team
Omori, Y.; Suzuki, M.; Ozaki, K.; Harada, Y.; Nakamura, Y.; Takahashi, E.; Fujiwara, T.
Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin
J. Hum. Genet.
43
169-177
1998
Homo sapiens (O15075), Homo sapiens
Manually annotated by BRENDA team
Nagase, T.; Ishikawa, K.; Nakajima, D.; Ohira, M.; Seki, N.; Miyajima, N.; Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
DNA Res.
4
141-150
1997
Homo sapiens (O15075)
Manually annotated by BRENDA team
Okazaki, N.; Yan, J.; Yuasa, S.; Ueno, T.; Kominami, E.; Masuho, Y.; Koga, H.; Muramatsu, M.
Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation
Brain Res. Mol. Brain Res.
85
1-12
2000
Homo sapiens (O75385)
Manually annotated by BRENDA team
Kuroyanagi, H.; Yan, J.; Seki, N.; Yamanouchi, Y.; Suzuki, Y.; Takano, T.; Muramatsu, M.; Shirasawa, T.
Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment
Genomics
51
76-85
1998
Homo sapiens (O75385), Homo sapiens
Manually annotated by BRENDA team
Sanjo, H.; Kawai, T.; Akira, S.
DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis
J. Biol. Chem.
273
29066-29071
1998
Homo sapiens (O94768), Homo sapiens (Q9UEE5)
Manually annotated by BRENDA team
Brown, A.L.; Lee, C.H.; Schwarz, J.K.; Mitiku, N.; Piwnica-Worms, H.; Chung, J.H.
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
Proc. Natl. Acad. Sci. USA
96
3745-3750
1999
Homo sapiens (O96017), Homo sapiens
Manually annotated by BRENDA team
Blasina, A.; de Weyer, I.V.; Laus, M.C.; Luyten, W.H.; Parker, A.E.; McGowan, C.H.
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Curr. Biol.
9
1-10
1999
Homo sapiens (O96017), Homo sapiens
Manually annotated by BRENDA team
Bell, D.W.; Varley, J.M.; Szydlo, T.E.; Kang, D.H.; Wahrer, D.C.; Shannon, K.E.; Lubratovich, M.; Verselis, S.J.; Isselbacher, K.J.; Fraumeni, J.F.; Birch, J.M.; Li, F.P.; Garber, J.E.; Haber, D.A.
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
Science
286
2528-2531
1999
Homo sapiens (O96017)
Manually annotated by BRENDA team
Matsuoka, S.; Huang, M.; Elledge, S.J.
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
Science
282
1893-1897
1998
Homo sapiens (O96017), Mus musculus (Q9Z265)
Manually annotated by BRENDA team
Zu, Y.L.; Wu, F.; Gilchrist, A.; Ai, Y.; Labadia, M.E.; Huang, C.K.
The primary structure of a human MAP kinase activated protein kinase 2
Biochem. Biophys. Res. Commun.
200
1118-1124
1994
Homo sapiens (P49137), Homo sapiens
Manually annotated by BRENDA team
Stokoe, D.; Caudwell, B.; Cohen, P.T.; Cohen, P.
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2
Biochem. J.
296
843-849
1993
Homo sapiens (P49137), Homo sapiens
Manually annotated by BRENDA team
Deiss, L.P.; Feinstein, E.; Berissi, H.; Cohen, O.; Kimchi, A.
Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death
Genes Dev.
9
15-30
1995
Homo sapiens (P53355)
Manually annotated by BRENDA team
Stapleton, D.; Mitchelhill, K.I.; Gao, G.; Widmer, J.; Michell, B.J.; Teh, T.; House, C.M.; Fernandez, C.S.; Cox, T.; Witters, L.A.; Kemp, B.E.
Mammalian AMP-activated protein kinase subfamily
J. Biol. Chem.
271
611-614
1996
Rattus norvegicus (P54645), Homo sapiens (Q13131)
Manually annotated by BRENDA team
Beri, R.K.; Marley, A.E.; See, C.G.; Sopwith, W.F.; Aguan, K.; Carling, D.; Scott, J.; Carey, F.
Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase
FEBS Lett.
356
117-121
1994
Homo sapiens (P54646)
Manually annotated by BRENDA team
Aguan, K.; Scott, J.; See, C.G.; Sarkar, N.H.
Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals
Gene
149
345-350
1994
Homo sapiens (P54646)
Manually annotated by BRENDA team
Westerman, A.M.; Entius, M.M.; Boor, P.P.; Koole, R.; de Baar, E.; Offerhaus, G.J.; Lubinski, J.; Lindhout, D.; Halley, D.J.; de Rooij, F.W.; Wilson, J.H.
Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families
Hum. Mutat.
13
476-481
1999
Homo sapiens (Q15831)
Manually annotated by BRENDA team
Nakagawa, H.; Koyama, K.; Miyoshi, Y.; Ando, H.; Baba, S.; Watatani, M.; Yasutomi, M.; Matsuura, N.; Monden, M.; Nakamura, Y.
Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome
Hum. Genet.
103
168-172
1998
Homo sapiens (Q15831)
Manually annotated by BRENDA team
Jenne, D.E.; Reimann, H.; Nezu, J.; Friedel, W.; Loff, S.; Jeschke, R.; Muller, O.; Back, W.; Zimmer, M.
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
Nat. Genet.
18
38-43
1998
Homo sapiens (Q15831), Homo sapiens
Manually annotated by BRENDA team
Hemminki, A.; Markie, D.; Tomlinson, I.; et al.
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
Nature
391
184-187
1998
Homo sapiens (Q15831)
Manually annotated by BRENDA team
Bignell, G.R.; Barfoot, R.; Seal, S.; Collins, N.; Warren, W.; Stratton, M.R.
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer
Cancer Res.
58
1384-1386
1998
Homo sapiens (Q15831)
Manually annotated by BRENDA team
Fish, K.J.; Cegielska, A.; Getman, M.E.; Landes, G.M.; Virshup, D.M.
Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family
J. Biol. Chem.
270
14875-14883
1995
Homo sapiens (P48729), Homo sapiens (P49674), Homo sapiens
Manually annotated by BRENDA team
Tapia, C.; Featherstone, T.; Gomez, C.; Taillon-Miller, P.; Allende, C.C.; Allende, J.E.
Cloning and chromosomal localization of the gene coding for human protein kinase CK1
FEBS Lett.
349
307-312
1994
Homo sapiens (P48729)
Manually annotated by BRENDA team
Kusuda, J.; Hidari, N.; Hirai, M.; Hashimoto, K.
Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization
Genomics
32
140-143
1996
Homo sapiens (P48730), Homo sapiens
Manually annotated by BRENDA team
Kitabayashi, A.N.; Kusuda, J.; Hirai, M.; Hashimoto, K.
Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2)
Genomics
46
133-137
1997
Homo sapiens (P78368), Homo sapiens
Manually annotated by BRENDA team
Kusuda, J.; Hirai, M.; Tanuma, R.; Hashimoto, K.
Cloning, expression analysis and chromosome mapping of human casein kinase 1 gamma1 (CSNK1G1): identification of two types of cDNA encoding the kinase protein associated with heterologous carboxy-terminal sequences
Cytogenet. Cell Genet.
90
298-302
2000
Homo sapiens (Q9HCP0), Homo sapiens
Manually annotated by BRENDA team
Kusuda, J.; Hirai, M.; Toyoda, A.; Tanuma, R.; Hashimoto, K.
Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3)
Cytogenet. Cell Genet.
83
101-103
1998
Homo sapiens (Q9Y6M4), Homo sapiens
Manually annotated by BRENDA team
Devilat, I.; Carvallo, P.
Structure and sequence of an intronless gene for human casein kinase II-alpha subunit
FEBS Lett.
316
114-118
1993
Homo sapiens (P68400), Homo sapiens
Manually annotated by BRENDA team
Litchfield, D.W.; Lozeman, F.J.; Piening, C.; Sommercorn, J.; Takio, K.; Walsh, K.A.; Krebs, E.G.
Subunit structure of casein kinase II from bovine testis. Demonstration that the alpha and alpha' subunits are distinct polypeptides
J. Biol. Chem.
265
7638-7644
1990
Bos taurus (P20427), Bos taurus, Homo sapiens (P68400)
Manually annotated by BRENDA team
Lozeman, F.J.; Litchfield, D.W.; Piening, C.; Takio, K.; Walsh, K.A.; Krebs, E.G.
Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II
Biochemistry
29
8436-8447
1990
Homo sapiens (P19784), Homo sapiens (P68400), Homo sapiens
Manually annotated by BRENDA team
Meisner, H.; Heller-Harrison, R.; Buxton, J.; Czech, M.P.
Molecular cloning of the human casein kinase II alpha subunit
Biochemistry
28
4072-4076
1989
Rattus norvegicus (P19139), Homo sapiens (P68400), Homo sapiens
Manually annotated by BRENDA team
ole-MoiYoi, O.K.; Brown, W.C.; Iams, K.P.; Nayar, A.; Tsukamoto, T.; Macklin, M.D.
Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva
EMBO J.
12
1621-1631
1993
Homo sapiens (P68400)
Manually annotated by BRENDA team
Allen, K.M.; Gleeson, J.G.; Bagrodia, S.; Partington, M.W.; MacMillan, J.C.; Cerione, R.A.; Mulley, J.C.; Walsh, C.A.
PAK3 mutation in nonsyndromic X-linked mental retardation
Nat. Genet.
20
25-30
1998
Homo sapiens (O75914), Homo sapiens
Manually annotated by BRENDA team
Johnston, A.M.; Naselli, G.; Gonez, L.J.; Martin, R.M.; Harrison, L.C.; DeAizpurua, H.J.
SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
Oncogene
19
4290-4297
2000
Rattus norvegicus (O88506), Homo sapiens (Q9UEW8), Mus musculus (Q9Z1W9)
Manually annotated by BRENDA team
Abo, A.; Qu, J.; Cammarano, M.S.; Dan, C.; Fritsch, A.; Baud, V.; Belisle, B.; Minden, A.
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
EMBO J.
17
6527-6540
1998
Homo sapiens (O96013)
Manually annotated by BRENDA team
Brown, J.L.; Stowers, L.; Baer, M.; Trejo, J.; Coughlin, S.; Chant, J.
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway
Curr. Biol.
6
598-605
1996
Homo sapiens (Q13153), Homo sapiens
Manually annotated by BRENDA team
Sells, M.A.; Knaus, U.G.; Bagrodia, S.; Ambrose, D.M.; Bokoch, G.M.; Chernoff, J.
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
Curr. Biol.
7
202-210
1997
Homo sapiens (Q13153), Homo sapiens
Manually annotated by BRENDA team
Benner, G.E.; Dennis, P.B.; Masaracchia, R.A.
Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation
J. Biol. Chem.
270
21121-21128
1995
Homo sapiens (Q13177)
Manually annotated by BRENDA team
Martin, G.A.; Bollag, G.; McCormick, F.; Abo, A.
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
EMBO J.
14
1970-1978
1995
Homo sapiens (Q13177), Homo sapiens
Manually annotated by BRENDA team
Martin, G.A.; Bollag, G.; McCormick, F.; Abo, A.
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
EMBO J.
14
4385
1995
Homo sapiens (Q13177)
Manually annotated by BRENDA team
Kojima, T.; Zama, T.; Wada, K.; Onogi, H.; Hagiwara, M.
Cloning of human PRP4 reveals interaction with Clk1
J. Biol. Chem.
276
32247-32256
2001
Homo sapiens (Q13523)
Manually annotated by BRENDA team
Grunau, C.; Hindermann, W.; Rosenthal, A.
Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes
Hum. Mol. Genet.
9
2651-2663
2000
Homo sapiens (Q9UPE1)
Manually annotated by BRENDA team
Nagase, T.; Ishikawa, K.; Miyajima, N.; Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
DNA Res.
5
31-39
1998
Homo sapiens (Q13523)
Manually annotated by BRENDA team
Gross, T.; Lutzelberger, M.; Weigmann, H.; Klingenhoff, A.; Shenoy, S.; Kaufer, N.F.
Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue
Nucleic Acids Res.
25
1028-1035
1997
Homo sapiens (Q13523), Mus musculus (Q61136)
Manually annotated by BRENDA team
Wang, Y.; Hofmann, T.G.; Runkel, L.; Haaf, T.; Schaller, H.; Debatin, K.; Hug, H.
Isolation and characterization of cDNAs for the protein kinase HIPK2
Biochim. Biophys. Acta
1518
168-172
2001
Homo sapiens (Q9H2X6), Homo sapiens, Mus musculus (Q9QZR5), Mus musculus
Manually annotated by BRENDA team
Li, X.; Wang, Y.; Debatin, K.M.; Hug, H.
The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells
Biochem. Biophys. Res. Commun.
277
513-517
2000
Homo sapiens (Q9H2X6)
Manually annotated by BRENDA team
Labeit, S.; Kolmerer, B.
Titins: giant proteins in charge of muscle ultrastructure and elasticity
Science
270
293-296
1995
Homo sapiens (Q8WZ42)
Manually annotated by BRENDA team
Gautel, M.; Castiglione Morelli, M.A.; Pfuhl, M.; Motta, A.; Pastore, A.
A calmodulin-binding sequence in the C-terminus of human cardiac titin kinase
Eur. J. Biochem.
230
752-759
1995
Homo sapiens (Q8WZ42), Homo sapiens
Manually annotated by BRENDA team
Taylor, L.K.; Wang, H.C.; Erikson, R.L.
Newly identified stress-responsive protein kinases, Krs-1 and Krs-2
Proc. Natl. Acad. Sci. USA
93
10099-10104
1996
Homo sapiens (Q13043), Homo sapiens (Q13188)
Manually annotated by BRENDA team
Schultz, S.J.; Fry, A.M.; Sutterlin, C.; Ried, T.; Nigg, E.A.
Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans
Cell Growth Differ.
5
625-635
1994
Homo sapiens (P51955), Homo sapiens (P51956), Homo sapiens (Q13188), Homo sapiens
Manually annotated by BRENDA team
Schultz, S.J.; Nigg, E.A.
Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans
Cell Growth Differ.
4
821-830
1993
Homo sapiens (P51955), Homo sapiens (P51956), Homo sapiens (Q13188), Homo sapiens
Manually annotated by BRENDA team
Pangilinan, F.; Li, Q.; Weaver, T.; Lewis, B.C.; Dang, C.V.; Spencer, F.
Mammalian BUB1 protein kinases: map positions and in vivo expression
Genomics
46
379-388
1997
Mus musculus (O08901), Homo sapiens (O43683)
Manually annotated by BRENDA team
Cahill, D.P.; da Costa, L.T.; Carson-Walter, E.B.; Kinzler, K.W.; Vogelstein, B.; Lengauer, C.
Characterization of MAD2B and other mitotic spindle checkpoint genes
Genomics
58
181-187
1999
Homo sapiens (O43683), Homo sapiens (O60566)
Manually annotated by BRENDA team
Taylor, S.S.; Ha, E.; McKeon, F.
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
J. Cell. Biol.
142
1-11
1998
Homo sapiens (O43683), Homo sapiens (O60566), Homo sapiens
Manually annotated by BRENDA team
Ouyang, B.; Lan, Z.; Meadows, J.; Pan, H.; Fukasawa, K.; Li, W.; Dai, W.
Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation
Cell Growth Differ.
9
877-885
1998
Homo sapiens (O43683)
Manually annotated by BRENDA team
Cahill, D.P.; Lengauer, C.; Yu, J.; Riggins, G.J.; Willson, J.K.; Markowitz, S.D.; Kinzler, K.W.; Vogelstein, B.
Mutations of mitotic checkpoint genes in human cancers
Nature
392
300-303
1998
Homo sapiens (O43683), Homo sapiens (O60566)
Manually annotated by BRENDA team
Davenport, J.W.; Fernandes, E.R.; Harris, L.D.; Neale, G.A.; Goorha, R.
The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner
Genomics
55
113-117
1999
Homo sapiens (O60566), Homo sapiens, Mus musculus (Q9Z1S0), Mus musculus
Manually annotated by BRENDA team
Chan, G.K.; Schaar, B.T.; Yen, T.J.
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
J. Cell. Biol.
143
49-63
1998
Homo sapiens (O60566)
Manually annotated by BRENDA team
Ohta, S.; Takeuchi, M.; Deguchi, M.; Tsuji, T.; Gahara, Y.; Nagata, K.
A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway
Biochem. J.
350
395-404
2000
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Rattus norvegicus (P57760)
Manually annotated by BRENDA team
Berson, A.E.; Young, C.; Morrison, S.L.; Fujii, G.H.; Sheung, J.; Wu, B.; Bolen, J.B.; Burkhardt, A.L.
Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase
Biochem. Biophys. Res. Commun.
259
533-538
1999
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Mus musculus
Manually annotated by BRENDA team
Ligos, J.M.; Gerwin, N.; Fernandez, P.; Gutierrez-Ramos, J.C.; Bernad, A.
Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases
Biochem. Biophys. Res. Commun.
249
380-384
1998
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Mus musculus
Manually annotated by BRENDA team
Hess, G.F.; Drong, R.F.; Weiland, K.L.; Slightom, J.L.; Sclafani, R.A.; Hollingsworth, R.E.
A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines
Gene
211
133-140
1998
Homo sapiens (O00311), Homo sapiens
Manually annotated by BRENDA team
Jiang, W.; Hunter, T.
Identification and characterization of a human protein kinase related to budding yeast Cdc7p
Proc. Natl. Acad. Sci. USA
94
14320-14325
1997
Homo sapiens (O00311), Homo sapiens
Manually annotated by BRENDA team
Sato, N.; Arai, K.; Masai, H.
Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7
EMBO J.
16
4340-4351
1997
Homo sapiens (O00311), Homo sapiens
Manually annotated by BRENDA team
Wang, P.J.; McCarrey, J.R.; Yang, F.; Page, D.C.
An abundance of X-linked genes expressed in spermatogonia
Nat. Genet.
27
422-426
2001
Mus musculus (Q99mw1), Homo sapiens (Q9BXU1)
Manually annotated by BRENDA team
Aoki, M.; Yokota, T.; Sugiura, I.; Sasaki, C.; Hasegawa, T.; Okumura, C.; Ishiguro, K.; Kohno, T.; Sugio, S.; Matsuzaki, T.
Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta
Acta Crystallogr. Sect. D
60
439-446
2004
Homo sapiens
Manually annotated by BRENDA team
Chen, X.; Lin, G.; Wei, Y.; Hexige, S.; Niu, Y.; Liu, L.; Yang, C.; Yu, L.
TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway
Biochem. Biophys. Res. Commun.
333
742-749
2005
Homo sapiens (Q6SA08), Homo sapiens
Manually annotated by BRENDA team
Bain, J.; McLauchlan, H.; Elliott, M.; Cohen, P.
The specificities of protein kinase inhibitors: an update
Biochem. J.
371
199-204
2003
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Biondi, R.M.; Nebreda, A.R.
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
Biochem. J.
372
1-13
2003
Homo sapiens (Q13153)
Manually annotated by BRENDA team
Hofmann, T.G.; Stollberg, N.; Schmitz, M.L.; Will, H.
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells
Cancer Res.
63
8271-8277
2003
Homo sapiens
Manually annotated by BRENDA team
Mottet, D.; Ruys, S.P.; Demazy, C.; Raes, M.; Michiels, C.
Role for casein kinase 2 in the regulation of HIF-1 activity
Int. J. Cancer
117
764-774
2005
Homo sapiens
Manually annotated by BRENDA team
Mukai, H.
The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC
J. Biochem.
133
17-27
2003
Asteroidea, Bos taurus, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis
Manually annotated by BRENDA team
Cho, J.H.; Johnson, G.V.
Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding
J. Biol. Chem.
278
187-193
2003
Homo sapiens
Manually annotated by BRENDA team
Tamaskovic, R.; Bichsel, S.J.; Rogniaux, H.; Stegert, M.R.; Hemmings, B.A.
Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase
J. Biol. Chem.
278
6710-6718
2003
Homo sapiens
Manually annotated by BRENDA team
Roosbeek, S.; Peelman, F.; Verhee, A.; Labeur, C.; Caster, H.; Lensink, M.F.; Cirulli, C.; Grooten, J.; Cochet, C.; Vandekerckhove, J.; Amoresano, A.; Chimini, G.; Tavernier, J.; Rosseneu, M.
Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter
J. Biol. Chem.
279
37779-37788
2004
Homo sapiens
Manually annotated by BRENDA team
Hernandez, F.; Perez, M.; Lucas, J.J.; Mata, A.M.; Bhat, R.; Avila, J.
Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease
J. Biol. Chem.
279
3801-3806
2004
Homo sapiens
Manually annotated by BRENDA team
Cho, J.H.; Johnson, G.V.
Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ
J. Biol. Chem.
279
54716-54723
2004
Homo sapiens
Manually annotated by BRENDA team
Stoothoff, W.H.; Cho, J.H.; McDonald, R.P.; Johnson, G.V.
FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation
J. Biol. Chem.
280
270-276
2005
Homo sapiens
Manually annotated by BRENDA team
Kenyon, T.K.; Homan, E.; Storlie, J.; Ikoma, M.; Grose, C.
Comparison of varicella-zoster virus ORF47 protein kinase and casein kinase II and their substrates
J. Med. Virol.
70 Suppl 1
S95-102
2003
Homo sapiens, Human alphaherpesvirus 3
Manually annotated by BRENDA team
Zhang, Y.; Li, H.L.; Wang, D.L.; Liu, S.J.; Wang, J.Z.
A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology
J. Neural Transm.
2
1-11
2006
Homo sapiens
Manually annotated by BRENDA team
Coito, C.; Diamond, D.L.; Neddermann, P.; Korth, M.J.; Katze, M.G.
High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein
J. Virol.
78
3502-3513
2004
Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Auer, A.; von Blume, J.; Sturany, S.; von Wichert, G.; Van Lint, J.; Vandenheede, J.; Adler, G.; Seufferlein, T.
Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling
Mol. Biol. Cell
16
4375-4385
2005
Homo sapiens
Manually annotated by BRENDA team
Lambourne, S.L.; Sellers, L.A.; Bush, T.G.; Choudhury, S.K.; Emson, P.C.; Suh, Y.H.; Wilkinson, L.S.
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities
Mol. Cell. Biol.
25
278-293
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Spiridonov, N.A.; Wong, L.; Zerfas, P.M.; Starost, M.F.; Pack, S.D.; Paweletz, C.P.; Johnson, G.R.
Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility
Mol. Cell. Biol.
25
4250-4261
2005
Mus musculus (Q925K9), Mus musculus, Homo sapiens (Q9BXA6), Homo sapiens
Manually annotated by BRENDA team
Willets, J.M.; Mistry, R.; Nahorski, S.R.; Challiss, R.A.
Specificity of G protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell M3 muscarinic acetylcholine receptor signaling
Mol. Pharmacol.
64
1059-1068
2003
Homo sapiens
Manually annotated by BRENDA team
Ahn, B.H.; Min, G.; Bae, Y.S.; Min do, S.
Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells
Exp. Mol. Med.
38
55-62
2006
Homo sapiens
Manually annotated by BRENDA team
Pagano, M.A.; Cesaro, L.; Meggio, F.; Pinna, L.A.
Protein kinase CK2: a newcomer in the druggable kinome
Biochem. Soc. Trans.
34
1303-1306
2006
Homo sapiens
Manually annotated by BRENDA team
Yan, Y.; Nguyen, H.; Dalmasso, G.; Sitaraman, S.V.; Merlin, D.
Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform
Biochim. Biophys. Acta
1769
106-116
2007
Homo sapiens (Q6E0B2)
Manually annotated by BRENDA team
Duncan, J.S.; Litchfield, D.W.
Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2
Biochim. Biophys. Acta
1784
33-47
2008
Homo sapiens
Manually annotated by BRENDA team
Haraga, A.; Miller, S.I.
A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1
Cell. Microbiol.
8
837-846
2006
Homo sapiens
Manually annotated by BRENDA team
Laramas, M.; Pasquier, D.; Filhol, O.; Ringeisen, F.; Descotes, J.L.; Cochet, C.
Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer
Eur. J. Cancer
43
928-934
2007
Homo sapiens
Manually annotated by BRENDA team
Price, M.A.
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling
Genes Dev.
20
399-410
2006
Drosophila melanogaster, Homo sapiens, Xenopus laevis
Manually annotated by BRENDA team
Guerra, B.
Protein kinase CK2 subunits are positive regulators of AKT kinase
Int. J. Oncol.
28
685-693
2006
Homo sapiens
Manually annotated by BRENDA team
Hanger, D.P.; Byers, H.L.; Wray, S.; Leung, K.Y.; Saxton, M.J.; Seereeram, A.; Reynolds, C.H.; Ward, M.A.; Anderton, B.H.
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
J. Biol. Chem.
282
23645-23654
2007
Homo sapiens
Manually annotated by BRENDA team
Foster, K.S.; McCrary, W.J.; Ross, J.S.; Wright, C.F.
Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt
Oncogene
25
4605-4612
2006
Homo sapiens
Manually annotated by BRENDA team
Bolanos-Garcia, V.M.; Fernandez-Recio, J.; Allende, J.E.; Blundell, T.L.
Identifying interaction motifs in CK2beta - a ubiquitous kinase regulatory subunit
Trends Biochem. Sci.
31
654-661
2006
Homo sapiens
Manually annotated by BRENDA team
Caples, M.J.; Clements, J.E.; Barber, S.A.
Protein kinase CK2 phosphorylates the Nef protein from a neurovirulent simian immunodeficiency virus
Virology
348
156-164
2006
Homo sapiens
Manually annotated by BRENDA team
Akita, S.; Umezawa, N.; Kato, N.; Higuchi, T.
Array-based fluorescence assay for serine/threonine kinases using specific chemical reaction
Bioorg. Med. Chem.
16
7788-7794
2008
Bos taurus, Homo sapiens (P31749)
Manually annotated by BRENDA team
Yoo, J.H.; Yoo, J.H.; Choi, Y.J.; Kang, J.G.; Sun, Y.K.; Ki, C.S.; Lee, K.A.; Choi, J.R.
A novel de novo mutation in the serine-threonine kinase STK11 gene in a Korean patient with Peutz-Jeghers syndrome
BMC Med. genet.
9
44
2008
Homo sapiens (Q15831), Homo sapiens
Manually annotated by BRENDA team
Kotliarova, S.; Pastorino, S.; Kovell, L.C.; Kotliarov, Y.; Song, H.; Zhang, W.; Bailey, R.; Maric, D.; Zenklusen, J.C.; Lee, J.; Fine, H.A.
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation
Cancer Res.
68
6643-6651
2008
Homo sapiens
Manually annotated by BRENDA team
Mills, S.J.; Vandeput, F.; Trusselle, M.N.; Safrany, S.T.; Erneux, C.; Potter, B.V.
Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the pH domain of protein kinase Balpha
ChemBioChem
9
1757-1766
2008
Homo sapiens
Manually annotated by BRENDA team
Cozzone, D.; Froejdoe, S.; Disse, E.; Debard, C.; Laville, M.; Pirola, L.; Vidal, H.
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients
Diabetologia
51
512-521
2008
Homo sapiens (P31749), Homo sapiens (P31751), Homo sapiens (Q9Y243), Homo sapiens
Manually annotated by BRENDA team
Oh, Y.; Herbst, R.S.; Burris, H.; Cleverly, A.; Musib, L.; Lahn, M.; Bepler, G.
Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer
J. Clin. Oncol.
26
1135-1141
2008
Homo sapiens
Manually annotated by BRENDA team
Enomoto, A.; Kido, N.; Ito, M.; Morita, A.; Matsumoto, Y.; Takamatsu, N.; Hosoi, Y.; Miyagawa, K.
Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38)
Oncogene
27
1930-1938
2008
Homo sapiens (Q15208)
Manually annotated by BRENDA team
Ragan, T.J.; Ross, D.B.; Keshwani, M.M.; Harris, T.K.
Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1)
Protein Expr. Purif.
57
271-279
2008
Homo sapiens (P23443)
Manually annotated by BRENDA team
Keshwani, M.M.; Ross, D.B.; Ragan, T.J.; Harris, T.K.
Baculovirus-mediated expression, purification, and characterization of a fully activated catalytic kinase domain construct of the 70 kDa 40S ribosomal protein S6 kinase-1 alphaII isoform (S6K1alphaII)
Protein Expr. Purif.
58
32-41
2008
Homo sapiens
Manually annotated by BRENDA team
Chen, H.; Van Duyne, R.; Zhang, N.; Kashanchi, F.; Zeng, C.
A novel binding pocket of cyclin-dependent kinase 2
Proteins
74
122-132
2008
Homo sapiens
Manually annotated by BRENDA team
Brown, D.A.; Yule, D.I.
Protein kinase A regulation of P2X(4) receptors: Requirement for a specific motif in the C-terminus
Biochim. Biophys. Acta
1803
275-287
2010
Homo sapiens
Manually annotated by BRENDA team
Bialik, S.; Kimchi, A.
Lethal weapons: DAP-kinase, autophagy and cell death DAP-kinase regulates autophagy
Curr. Opin. Cell Biol.
22
199-205
2010
Homo sapiens
Manually annotated by BRENDA team
Swords, R.; Mahalingam, D.; ODwyer, M.; Santocanale, C.; Kelly, K.; Carew, J.; Giles, F.
Cdc7 kinase - a new target for drug development
Eur. J. Cancer
46
33-40
2010
Homo sapiens
Manually annotated by BRENDA team
Anand, V.S.; Reichling, L.J.; Lipinski, K.; Stochaj, W.; Duan, W.; Kelleher, K.; Pungaliya, P.; Brown, E.L.; Reinhart, P.H.; Somberg, R.; Hirst, W.D.; Riddle, S.M.; Braithwaite, S.P.
Investigation of leucine-rich repeat kinase 2: enzymological properties and novel assays
FEBS J.
276
466-478
2009
Homo sapiens
Manually annotated by BRENDA team
Bi, J.; Lau, S.H.; Hu, L.; Rao, H.L.; Liu, H.B.; Zhan, W.H.; Chen, G.; Wen, J.M.; Wang, Q.; Li, B.; Guan, X.Y.
Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer
Int. J. Cancer
124
1587-1593
2009
Homo sapiens
Manually annotated by BRENDA team
Lee, C.H.; Liu, C.M.; Wen, C.C.; Chang, S.M.; Hwu, H.G.
Genetic copy number variants in sib pairs both affected with schizophrenia
J. Biomed. Sci.
17
2-2
2010
Homo sapiens
Manually annotated by BRENDA team
Aliagas-Martin, I.; Burdick, D.; Corson, L.; Dotson, J.; Drummond, J.; Fields, C.; Huang, O.W.; Hunsaker, T.; Kleinheinz, T.; Krueger, E.; Liang, J.; Moffat, J.; Phillips, G.; Pulk, R.; Rawson, T.E.; Ultsch, M.; Walker, L.; Wiesmann, C.; Zhang, B.; Zhu, B.Y.; Cochran, A.G.
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B
J. Med. Chem.
52
3300-3307
2009
Homo sapiens (O14965)
Manually annotated by BRENDA team
Eiseler, T.; Doeppler, H.; Yan, I.K.; Kitatani, K.; Mizuno, K.; Storz, P.
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility via slingshot
Nat. Cell Biol.
11
545-556
2009
Homo sapiens
Manually annotated by BRENDA team
Maloverjan, A.; Piirsoo, M.; Michelson, P.; Kogerman, P.; Osterlund, T.
Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway
Exp. Cell Res.
316
627-637
2010
Homo sapiens (Q6PHR2), Homo sapiens
Manually annotated by BRENDA team
Cheong, J.; Virshup, D.
Casein kinase 1: complexity in the family
Int. J. Biochem. Cell Biol.
43
465-469
2011
Homo sapiens
Manually annotated by BRENDA team
Lin C.; Tsai S.C.; Tseng M.T.; Peng S.F.; Kuo S.C.; Lin M.W.; Hsu Y.M.; Lee M.R.; Amagaya S.; Huang W.W.; Wu T.S.; Yang J.S.
AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells
Int. J. Oncol.
42
993-1000
2013
Homo sapiens
Manually annotated by BRENDA team
Calamaras, T.; Lee, C.; Lan, F.; Ido, Y.; Siwik, D.; Colucci, W.
Post-translational modification of serine/threonine kinase LKB1 via adduction of the reactive lipid species 4-hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity
J. Biol. Chem.
287
42400-42406
2012
Homo sapiens
Manually annotated by BRENDA team
Asano, J.; Nakano, A.; Oda, A.; Amou, H.; Hiasa, M.; Takeuchi, K.; Miki, H.; Nakamura, S.; Harada, T.; Fujii, S.; Kagawa, K.; Endo, I.; Yata, K.; Sakai, A.; Ozaki, S.; Matsumoto, T.; Abe, M.
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells
Leukemia
25
1182-1188
2011
Homo sapiens
Manually annotated by BRENDA team
Matheny, R.W.; Geddis, A.V.; Abdalla, M.N.; Leandry, L.A.
Phosphatidylinositol 3-kinase p110alpha mediates phosphorylation of AMP-activated protein kinase in myoblasts
Biochem. Biophys. Res. Commun.
469
1117-1122
2016
Homo sapiens (P42336)
Manually annotated by BRENDA team
Hu, L.; Chen, H.; Cai, J.; Zhang, Y.; Qi, C.; Gong, H.; Zhai, Y.; Fu, H.; Yang, G.; Gao, C.
Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer
BMC Cancer
15
246
2015
Homo sapiens
Manually annotated by BRENDA team
Kim, S.; Ezhilarasan, R.; Phillips, E.; Gallego-Perez, D.; Sparks, A.; Taylor, D.; Ladner, K.; Furuta, T.; Sabit, H.; Chhipa, R.; Cho, J.; Mohyeldin, A.; Beck, S.; Kurozumi, K.; Kuroiwa, T.; Iwata, R.; Asai, A.; Kim, J.; Sulman, E.; Cheng, S.; Lee, L.; Na
Serine/threonine kinase MLK4 determines mesenchymal identity in glioma stem cells in an NF-kappaB-dependent manner
Cancer Cell
29
201-213
2016
Homo sapiens
Manually annotated by BRENDA team
Enerbaeck, S.
Casein kinase 2 - A kinase that inhibits brown fat formation
Cell Metab.
22
958-959
2015
Homo sapiens
Manually annotated by BRENDA team
Fukasawa, T.; Enomoto, A.; Miyagawa, K.
Serine-threonine kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint
Cell. Signal.
27
1569-1575
2015
Homo sapiens (Q15208)
Manually annotated by BRENDA team
Watson, L.J.; Alexander, K.M.; Mohan, M.L.; Bowman, A.L.; Mangmool, S.; Xiao, K.; Naga Prasad, S.V.; Rockman, H.A.
Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation
Cell. Signal.
28
1580-1592
2016
Homo sapiens (P48736)
Manually annotated by BRENDA team
Sommer, L.; Schaad, M.; Dames, S.
NMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK)
J. Biol. Chem.
288
20046-20063
2013
Homo sapiens (P78527), Homo sapiens (Q13315), Homo sapiens (Q13535), Homo sapiens (Q96Q15)
Manually annotated by BRENDA team
Somoza, J.R.; Koditek, D.; Villasenor, A.G.; Novikov, N.; Wong, M.H.; Liclican, A.; Xing, W.; Lagpacan, L.; Wang, R.; Schultz, B.E.; Papalia, G.A.; Samuel, D.; Lad, L.; McGrath, M.E.
Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase delta
J. Biol. Chem.
290
8439-8446
2015
Homo sapiens (O00329)
Manually annotated by BRENDA team
Mohl, B.; Roy, P.
Cellular casein kinase 2 and protein phosphatase 2A modulate replication site assembly of bluetongue virus
J. Biol. Chem.
291
14566-14574
2016
Homo sapiens
Manually annotated by BRENDA team
Chan, T.; Cheung, F.; Zheng, J.; Lu, X.; Zhu, L.; Grewal, T.; Murray, M.; Zhou, F.
Casein kinase 2 is a novel regulator of the human organic anion transporting polypeptide 1A2 (OATP1A2) trafficking
Mol. Pharm.
13
144-154
2016
Homo sapiens
Manually annotated by BRENDA team
Cerda, O.; Caceres, M.; Park, K.; Leiva-Salcedo, E.; Romero, A.; Varela, D.; Trimmer, J.; Stutzin, A.
Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4
Pflugers Arch.
467
1723-1732
2015
Homo sapiens
Manually annotated by BRENDA team
Thomas, D.; Powell, J.A.; Green, B.D.; Barry, E.F.; Ma, Y.; Woodcock, J.; Fitter, S.; Zannettino, A.C.; Pitson, S.M.; Hughes, T.P.; Lopez, A.F.; Shepherd, P.R.; Wei, A.H.; Ekert, P.G.; Guthridge, M.A.
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival
PLoS Biol.
11
e1001515
2013
Homo sapiens (P42336)
Manually annotated by BRENDA team
Herhaus, L.; Perez-Oliva, A.; Cozza, G.; Gourlay, R.; Weidlich, S.; Campbell, D.; Pinna, L.; Sapkota, G.
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization
Sci. Signal.
8
ra35
2015
Homo sapiens
Manually annotated by BRENDA team
An, N.; Lin, Y.; Mahajan, S.; Kellner, J.; Wang, Y.; Li, Z.; Kraft, A.; Kang, Y.
Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells
Stem Cells
31
1202-1212
2013
Homo sapiens
Manually annotated by BRENDA team
Aramini, J.; Vorobiev, S.; Tuberty, L.; Janjua, H.; Campbell, E.; Seetharaman, J.; Su, M.; Huang, Y.; Acton, T.; Xiao, R.; Tong, L.; Montelione, G.
The RAS-binding domain of human BRAF protein serine/threonine kinase exhibits allosteric conformational changes upon binding HRAS
Structure
23
1382-1393
2015
Homo sapiens (P15056)
Manually annotated by BRENDA team
Chai, J.; Wang, S.; Han, D.; Dong, W.; Xie, C.; Guo, H.
MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase
Tumor Biol.
36
1313-1321
2015
Homo sapiens
Manually annotated by BRENDA team
Enerbaeck, S.
Casein kinase 2 - a kinase that inhibits brown fat formation
Cell Metab.
22
958-959
2015
Homo sapiens
Manually annotated by BRENDA team
Fukasawa, T.; Enomoto, A.; Miyagawa, K.
Serine-threonine kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint
Cell. Signal.
27
1569-1575
2015
Homo sapiens (Q15208)
-
Manually annotated by BRENDA team
Mohl, B.; Roy, P.
Cellular casein kinase 2 and protein phosphatase 2A modulate replication site assembly of bluetongue virus
J. Biol. Chem.
291
14566-14574
2016
Homo sapiens
Manually annotated by BRENDA team
Greer, Y.; Westlake, C.; Gao, B.; Bharti, K.; Shiba, Y.; Xavier, C.; Pazour, G.; Yang, Y.; Rubin, J.
Casein kinase 1delta functions at the centrosome and Golgi to promote ciliogenesis
Mol. Biol. Cell
25
1629-1640
2014
Homo sapiens (P48730), Mus musculus (Q9DC28)
-
Manually annotated by BRENDA team
Cerda, O.; Caceres, M.; Park, K.; Leiva-Salcedo, E.; Romero, A.; Varela, D.; Trimmer, J.; Stutzin, A.
Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4
Pflugers Arch.
467
1723-1732
2015
Homo sapiens
-
Manually annotated by BRENDA team
Herhaus, L.; Perez-Oliva, A.; Cozza, G.; Gourlay, R.; Weidlich, S.; Campbell, D.; Pinna, L.; Sapkota, G.
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization
Sci. Signal.
8
ra35
2015
Homo sapiens
-
Manually annotated by BRENDA team
An, N.; Lin, Y.; Mahajan, S.; Kellner, J.; Wang, Y.; Li, Z.; Kraft, A.; Kang, Y.
Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells
Stem Cells
31
1202-1212
2013
Mus musculus (P06803), Mus musculus, Homo sapiens (P11309), Homo sapiens
Manually annotated by BRENDA team
Chai, J.; Wang, S.; Han, D.; Dong, W.; Xie, C.; Guo, H.
MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase
Tumor Biol.
36
1313-1321
2015
Homo sapiens
-
Manually annotated by BRENDA team
Kim, H.; Han, Y.; Lee, J.; Lee, S.
Casein kinase 2alpha enhances 5-fluorouracil resistance in colorectal cancer cells by inhibiting endoplasmic reticulum stress
Anticancer Res.
40
1419-1426
2020
Homo sapiens
Manually annotated by BRENDA team
Roach, B.; Ngo, J.; Limso, C.; Oloja, K.; Bhandari, D.
Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5
Biochem. Biophys. Res. Commun.
504
753-758
2018
Homo sapiens (Q00535)
Manually annotated by BRENDA team
Meng, Z.; Bhm, T.; Xu, P.; Henne-Bruns, D.; Peifer, C.; Witt, L.; Knippschild, U.; Bischof, J.
Kinase activity of casein kinase 1 delta (CK1delta) is modulated by protein kinase Calpha (PKCalpha) by site-specific phosphorylation within the kinase domain of CK1delta
Biochim. Biophys. Acta Proteins Proteom.
1867
710-721
2019
Homo sapiens (P48730)
Manually annotated by BRENDA team
Karthikeyan, C.; Jharia, P.; Waiker, D.; Nusbaum, A.; Amawi, H.; Kirwen, E.; Christman, R.; Arudra, S.; Meijer, L.; Tiwari, A.; Trivedi, P.
N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1delta/epsion inhibitors synthesis, biological evaluation and molecular modeling studies
Bioorg. Med. Chem. Lett.
27
2663-2667
2017
Homo sapiens (P48730)
Manually annotated by BRENDA team
Hawkinson, J.; Sinville, R.; Mudaliar, D.; Shetty, J.; Ward, T.; Herr, J.; Georg, G.
Potent pyrimidine and pyrrolopyrimidine inhibitors of testis-specific serine/threonine kinase 2 (TSSK2)
ChemMedChem
12
1857-1865
2017
Homo sapiens (Q96PF2)
Manually annotated by BRENDA team
Rozpedek, W.; Pytel, D.; Nowak-Zdunczyk, A.; Lewko, D.; Wojtczak, R.; Diehl, J.; Majsterek, I.
Breaking the DNA damage response via serine/threonine kinase inhibitors to improve cancer treatment
Curr. Med. Chem.
26
1425-1445
2019
Homo sapiens (Q13315), Homo sapiens (Q13535), Homo sapiens (Q9NZJ5)
Manually annotated by BRENDA team
Gocher, A.; Azabdaftari, G.; Euscher, L.; Dai, S.; Karacosta, L.; Franke, T.; Edelman, A.
Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells
J. Biol. Chem.
292
14188-14204
2017
Homo sapiens (P31749)
Manually annotated by BRENDA team
Su, Y.; Song, P.; Wang, H.; Hu, B.; Wang, J.; Cheng, M.
Precise design of highly isoform-selective p21-activated kinase 4 inhibitors computational insights into the selectivity mechanism through molecular dynamics simulation and binding free energy calculation
J. Biomol. Struct. Dyn.
38
3825-3837
2020
Homo sapiens (O96013), Homo sapiens (Q13153)
Manually annotated by BRENDA team
Majumdar, A.; Ahmad, F.; Sheikh, T.; Bhagat, R.; Pathak, P.; Joshi, S.; Seth, P.; Tandon, V.; Tripathi, M.; Saratchandra, P.; Sarkar, C.; Sen, E.
miR-217-casein kinase-2 cross talk regulates ERK activation in ganglioglioma
J. Mol. Med.
95
1215-1226
2017
Homo sapiens (P68400), Homo sapiens
Manually annotated by BRENDA team
Dick, S.; Federico, S.; Hughes, S.; Pye, V.; OReilly, N.; Cherepanov, P.
Structural basis for the activation and target site specificity of CDC7 kinase
Structure
28
954-962.e4
2020
Homo sapiens (O00311), Homo sapiens
Manually annotated by BRENDA team