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ATP + 3-hydroxy-3-methylglutaryl-CoA reductase
ADP + phosphorylated 3-hydroxy-3-methylglutaryl-CoA reductase
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
autophosphorylation when incubated with ATP and Mg2+
-
-
?
ATP + acetyl-CoA carboxylase
ADP + phosphorylated acetyl-CoA carboxylase
-
-
-
?
ATP + Akt
ADP + phosphorylated Akt
ATP + Akt (MBP)
ADP + phosphorylated-Akt
purified Pak1 can directly phosphorylate Akt only at Ser473, suggesting that Pak1 may be a relevant PDK2 responsible for AKT Ser473 phosphorylation in cardiomyocytes
-
-
?
ATP + C/EBPalpha
ADP + phosphorylated C/EBPalpha
ATP + C/EBPbeta
ADP + phosphorylated C/EBPbeta
ATP + casein
ADP + phosphorylated casein
ATP + claudin-4
ADP + phosphorylated claudin-4
-
recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli
-
-
?
ATP + DDDDVASLPGLRRR
ADP + ?
-
-
-
?
ATP + histone
ADP + phosphorylated histone
-
-
-
-
?
ATP + histone f1
?
-
lysine-rich histone, phosphorylated at a specific serine residue
-
-
?
ATP + mPer1
ADP + phosphorylated mPer1
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
recombinant WNK1 or WNK4 expressed in Escherichia coli
-
-
?
ATP + myelin basic protein (MBP)
ADP + phosphorylated-myelin basic protein
-
-
-
?
ATP + NKCC1-(1-260)
ADP + phosphorylated NKCC1-(1-260)
-
i.e. Na+-K+-2Cl- co-transporter-1-(1-260) construct, recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli
-
-
?
ATP + NS5A protein
ADP + phosphorylated NS5A protein
-
recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by several serine/threonine protein kinases, e.g. casein kinase 1, phosphorylation pattern, overview
-
-
?
ATP + oxidative stress response kinase 1 OSR1
ADP + phosphorylated oxidative stress response kinase 1 OSR1
-
recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli, phosphorylation at Ser325 and Thr185, the latter is required for activation of OSR1
-
-
?
ATP + PACSIN 1 protein
ADP + phospho-PACSIN 1 protein
i.e. casein kinase 2 substrate in neurons 1 protein, casein kinase 2 phosphorylates PACSIN 1 at Ser358, no activity with PACSIN1 mutant S358A. Ser358 is located within the unstructured linker sequence connecting the N-terminal F-BAR domain with the C-terminal SH3 domain
-
-
?
ATP + phosphoglycogen synthase peptide 2
ADP + phosphorylated phosphoglycogen synthase peptide 2
-
-
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
ATP + protein
ADP + a phosphoprotein
-
-
-
?
ATP + protein
ADP + phosphoprotein
ATP + protein kinase C
ADP + phospho-protein kinase C
-
-
-
?
ATP + S6 protein of the 40s ribosomal subunit
ADP + phosphorylated S6 protein of the 40s ribosomal subunit
the mitogen-activated protein kinase plays a central role in the control of mRNA translation. It physiologically phosphorylates the S6 protein of the 40s ribosomal subunit in response to mitogenic stimuli and is a downstream component of the rapamycin-sensitive pathway, which includes the 12-kDa FK506 binding protein and includes rapamycin and the 12-kDa FK506 binding protein target 1
-
-
?
ATP + SR protein
ADP + ?
implication of KIS in the control of trafficking and/or splicing of RNAs probably through phosphorylation of associated factors
-
-
?
ATP + SREBP-1c
ADP + phospho-SREBP-1c
ATP + stathmin
ADP + phosphorylated stathmin
phosphorylates on Ser
-
-
?
ATP + STE/SPS1-related proline/alanine-rich kinase SPAK
ADP + phosphorylated STE/SPS1-related proline/alanine-rich kinase SPAK
-
recombinant WNK1 or WNK4 with recombinant protein substrate, both expressed in Escherichia coli
-
-
?
ATP + synaptotagmin 2
ADP + phosphorylated synaptotagmin 2
-
WNK1 specific substrate
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
casein + ATP
phosphorylated casein + ADP
-
-
-
?
additional information
?
-
ATP + Akt
ADP + phosphorylated Akt
-
CK2 phosphorylates and activates Akt directly
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
CK2 phosphorylates and activates Akt directly, phosphorylation at Ser473
-
-
?
ATP + C/EBPalpha
ADP + phosphorylated C/EBPalpha
-
-
-
-
?
ATP + C/EBPalpha
ADP + phosphorylated C/EBPalpha
-
phosphorylation at consensus sequence (S/T)XXX(S/T) with X representing any amino acid
-
-
?
ATP + C/EBPbeta
ADP + phosphorylated C/EBPbeta
-
-
-
-
?
ATP + C/EBPbeta
ADP + phosphorylated C/EBPbeta
-
phosphorylation at multiple sites, preferably at Thr189 and Ser185, reduced activity with mutants T189A and S185A, mutation of either site appears to impair phosphorylation of neighbouring sites
-
-
?
ATP + casein
ADP + phosphorylated casein
-
-
-
?
ATP + casein
ADP + phosphorylated casein
-
-
-
?
ATP + casein
ADP + phosphorylated casein
-
substrate of CK1 and CK2
-
-
?
ATP + mPer1
ADP + phosphorylated mPer1
CK1epsilon-1
-
-
?
ATP + mPer1
ADP + phosphorylated mPer1
CKIepsilon-3
-
-
?
ATP + phosvitin
ADP + ?
-
-
-
?
ATP + phosvitin
ADP + ?
-
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
-
preferred substrate
-
?
ATP + protamine
ADP + O-phosphoprotamine
-
phosphorylates threonine residues
-
?
ATP + protamine
ADP + O-phosphoprotamine
-
phosphorylates serine
-
?
ATP + protamine
ADP + O-phosphoprotamine
-
no substrates are acidic proteins, e.g. casein, phosvitin
-
?
ATP + protamine
ADP + O-phosphoprotamine
-
no substrates are acidic proteins, e.g. casein, phosvitin
-
?
ATP + protamine
ADP + O-phosphoprotamine
-
no substrates are acidic proteins, e.g. casein, phosvitin
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals
-
-
?
ATP + SREBP-1c
ADP + phospho-SREBP-1c
sterol response element binding protein-1c, phosphorylation of Ser73
-
-
?
ATP + SREBP-1c
ADP + phospho-SREBP-1c
sterol response element binding protein-1c phosphorylation of Ser73
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
abnormal hyperphosphorylation of tau by GSK-3 is associated with Alzheimer's disease and other tauopathies leading to neuronal degeneration
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
phosphorylation by GSK-3 at Ser404, Ser396, Ser198, Ser199, and Ser202
-
-
?
additional information
?
-
interaction between RAC-PK and protein kinase C
-
-
?
additional information
?
-
interaction between RAC-PK and protein kinase C
-
-
?
additional information
?
-
the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element
-
-
?
additional information
?
-
the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element
-
-
?
additional information
?
-
the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element
-
-
?
additional information
?
-
induction of sgk gene may be associated with a series of axonal regenerations after brain injury, and in addition, the sgk gene may also play important roles in the development of particular groups of neurons in the postnatal brain
-
-
?
additional information
?
-
enzyme is induced during ovarian cell differentiation
-
-
?
additional information
?
-
the enzyme is highly regulated at the transcriptional level by glucocorticoid hormones
-
-
?
additional information
?
-
SGK is a component of the phosphoinositide 3 (PI 3)-kinase signaling pathway
-
-
?
additional information
?
-
enzyme plays a major role in the regulation of lipid metabolism, be involved in the regulation of a wide range of metabolic pathways
-
-
?
additional information
?
-
enzyme is implicated in the control of cell growth and proliferation. Androgenic regulation of CK-2 gene transcription is not an early event related to androgen action, but is substantial in the prereplicative phase of prostatic cell proliferation mediated by androgen. Androgenic stimulation of the mRNA expression for the alpha and beta subunits of CK-2 appears to be differential
-
-
?
additional information
?
-
-
isozyme RSK1, i.e. 14-3-3, is regulated by inhibitory binding of 14-3-3beta, a RSK1-binding protein, to Lys49 of the enzyme, Lys49 is also responsible for interaction of RSK1 with Bcr, Raf, and Cbl
-
-
?
additional information
?
-
-
phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis
-
-
?
additional information
?
-
-
regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization, overview
-
-
?
additional information
?
-
-
tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory
-
-
?
additional information
?
-
-
WKN1 and WKN4 are involved in regulation of ion transport across diverse epithelia, WKN4 reduces the activity of Na-Cl-cotransporter activity and the potassium channel ROMK by reducing their appearance in the plasma membrane
-
-
?
additional information
?
-
-
WNK1 causes a hereditary form of hypertension, pseudohypoaldosteronism type II
-
-
?
additional information
?
-
-
enzyme performs autophosphorylation, PKN binds several associated proteins via its ACC domain, i.e. RhoA, a small GTPase, which binds to the ACC domain of PKNalpha forming a catalytic active site
-
-
?
additional information
?
-
-
GSK-3 catalyzes tau phosphorylation in the brain, while it performs phosphorylation of glycogen synthase and other proteins in other tissues
-
-
?
additional information
?
-
-
WKN1 and WKN4 perform autophosphorylation
-
-
?
additional information
?
-
-
WNK1 interacts with OSR1 and SPAK, overview
-
-
?
additional information
?
-
-
WNK1 performs autophosphorylation at S382 for activation
-
-
?
additional information
?
-
-
CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling by activation of Akt and inactivation of SGK1 through protein phosphatase 2A
-
-
?
additional information
?
-
-
CK2 inhibition increases SGK1 phosphorylation at Ser422
-
-
?
additional information
?
-
dynamin is not phosphorylated in the cytosol, and SNAP-47 is not phosphorylated at all
-
-
?
additional information
?
-
recombinant expression of His6- or HA-tagged full-length substrate SREBP-1c and its loss-of-function mutant S73A and gain-of-function mutant S73D in McA-RH7777 cells, overview. The sequence surrounding serine 73 of rat SREBP-1c resembles a canonical cdc4 phosphodegron (CPD) that is a recognized substrate of the SCFFbw7 ubiquitin ligase
-
-
?
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Nunoue, K.; Ohashi, K.; Okano, I.; Mizuno, K.
LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family
Oncogene
11
701-710
1995
Rattus norvegicus (P53669)
brenda
O'Donovan, C.; Martin, M.J.; Gattiker, A.; Gasteiger, E.; Bairoch, A.; Apweiler, R.
High quality protein knowledge resources: Swiss-Prot and TrEMBL
Brief. Bioinform.
2
275-284
2002
Rattus norvegicus (Q63802)
-
brenda
Stephens, L.; Anderson, K.; Stokoe, D.; Erdjument-Bromage, H.; Painter, G.F.; et al.
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
Science
279
710-714
1998
Rattus norvegicus (O55173)
brenda
Burnett, P.E.; Blackshaw, S.; Lai, M.M.; Qureshi, I.A.; Burnett, A.F.; Sabatini, D.M.; Snyder, S.H.
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton
Proc. Natl. Acad. Sci. USA
95
8351-8356
1998
Rattus norvegicus (P67999)
brenda
Kozma, S.C.; Ferrari, S.; Bassand, P.; Siegmann, M.; Totty, N.; Thomas, G.
Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily
Proc. Natl. Acad. Sci. USA
87
7365-7369
1990
Rattus norvegicus (P67999)
brenda
Harmann, B.; Kilimann, M.W.
cDNA encoding a 59 kDa homolog of ribosomal protein S6 kinase from rabbit liver
FEBS Lett.
273
248-252
1990
Rattus norvegicus (P67999)
brenda
Banerjee, P.; Ahmad, M.F.; Grove, J.R.; Kozlosky, C.; Price, D.J.; Avruch, J.
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase
Proc. Natl. Acad. Sci. USA
87
8550-8554
1990
Rattus norvegicus (P67999)
brenda
Konishi, H.; Shinomura, T.; Kuroda, S.; Ono, Y.; Kikkawa, U.
Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta
Biochem. Biophys. Res. Commun.
205
817-825
1994
Rattus norvegicus (P47196), Rattus norvegicus (P47197)
brenda
Park, J.; Leong, M.L.; Buse, P.; Maiyar, A.C.; Firestone, G.L.; Hemmings, B.A.
Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
EMBO J.
18
3024-3033
1999
Rattus norvegicus (Q06226)
brenda
Richards, J.S.; Fitzpatrick, S.L.; Clemens, J.W.; Morris, J.K.; Alliston, T.; Sirois, J.
Ovarian cell differentiation: a cascade of multiple hormones, cellular signals, and regulated genes
Recent Prog. Horm. Res.
50
223-254
1995
Rattus norvegicus (Q06226)
brenda
Imaizumi, K.; Tsuda, M.; Wanaka, A.; Tohyama, M.; Takagi, T.
Differential expression of sgk mRNA, a member of the Ser/Thr protein kinase gene family, in rat brain after CNS injury
Brain Res. Mol. Brain Res.
26
189-196
1994
Rattus norvegicus (Q06226)
brenda
Webster, M.K.; Goya, L.; Ge, Y.; Maiyar, A.C.; Firestone, G.L.
Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
Mol. Cell. Biol.
13
2031-2040
1993
Rattus norvegicus (Q06226)
brenda
Konishi, H.; Kuroda, S.; Tanaka, M.; Matsuzaki, H.; Ono, Y.; Kameyama, K.; Haga, T.; Kikkawa, U.
Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins
Biochem. Biophys. Res. Commun.
216
526-534
1995
Rattus norvegicus (Q63484)
brenda
Grove, J.R.; Price, D.J.; Banerjee, P.; Balasubramanyam, A.; Ahmad, M.F.; Avruch, J.
Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase
Biochemistry
32
7727-7738
1993
Rattus norvegicus (Q63531)
brenda
Hevroni, D.; Rattner, A.; Bundman, M.; et al.
Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms
J. Mol. Neurosci.
10
75-98
1998
Rattus norvegicus (O08875)
brenda
Stapleton, D.; Mitchelhill, K.I.; Gao, G.; Widmer, J.; Michell, B.J.; Teh, T.; House, C.M.; Fernandez, C.S.; Cox, T.; Witters, L.A.; Kemp, B.E.
Mammalian AMP-activated protein kinase subfamily
J. Biol. Chem.
271
611-614
1996
Rattus norvegicus (P54645), Homo sapiens (Q13131)
brenda
Stapleton, D.; Gao, G.; Michell, B.J.; Widmer, J.; Mitchelhill, K.; Teh, T.; House, C.M.; Witters, L.A.; Kemp, B.E.
Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase
J. Biol. Chem.
269
29343-29346
1994
Rattus norvegicus (P54645)
brenda
Gao, G.; Widmer, J.; Stapleton, D.; Teh, T.; Cox, T.; Kemp, B.E.; Witters, L.A.
Catalytic subunits of the porcine and rat 5'-AMP-activated protein kinase are members of the SNF1 protein kinase family
Biochim. Biophys. Acta
1266
73-82
1995
Rattus norvegicus (Q09137)
brenda
Carling, D.; Aguan, K.; Woods, A.; Verhoeven, A.J.; Beri, R.K.; Brennan, C.H.; Sidebottom, C.; Davison, M.D.; Scott, J.
Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism
J. Biol. Chem.
269
11442-11448
1994
Rattus norvegicus (Q09137)
brenda
Hata, Y.; Butz, S.; Sudhof, T.C.
CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins
J. Neurosci.
16
2488-2494
1996
Rattus norvegicus (Q62915)
brenda
Zhang, J.; Gross, S.D.; Schroeder, M.D.; Anderson, R.A.
Casein kinase I alpha and alpha L: alternative splicing-generated kinases exhibit different catalytic properties
Biochemistry
35
16319-16327
1996
Rattus norvegicus (P97633)
brenda
Graves, P.R.; Haas, D.W.; Hagedorn, C.H.; DePaoli-Roach, A.A.; Roach, P.J.
Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis
J. Biol. Chem.
268
6394-6401
1993
Rattus norvegicus (Q06486)
brenda
Longenecker, K.L.; Roach, P.J.; Hurley, T.D.
Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition
J. Mol. Biol.
257
618-631
1996
Rattus norvegicus (Q06486)
brenda
Zhai, L.; Graves, P.R.; Robinson, L.C.; Italiano, M.; Culbertson, M.R.; Rowles, J.; Cobb, M.H.; DePaoli-Roach, A.A.; Roach, P.J.
Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes
J. Biol. Chem.
270
12717-12724
1995
Rattus norvegicus (Q62761), Rattus norvegicus (Q62762), Rattus norvegicus (Q62763)
brenda
Ahmed, K.; Davis, A.; Hanten, J.; Lambert, D.; McIvor, R.S.; Goueli, S.A.
Cloning of cDNAs encoding the alpha and beta subunits of rat casein kinase 2 (CK-2): investigation of molecular regulation of CK-2 by androgens in rat ventral prostate
Cell. Mol. Biol. Res.
39
451-462
1993
Rattus norvegicus (P19139)
brenda
Meisner, H.; Heller-Harrison, R.; Buxton, J.; Czech, M.P.
Molecular cloning of the human casein kinase II alpha subunit
Biochemistry
28
4072-4076
1989
Rattus norvegicus (P19139), Homo sapiens (P68400), Homo sapiens
brenda
Johnston, A.M.; Naselli, G.; Gonez, L.J.; Martin, R.M.; Harrison, L.C.; DeAizpurua, H.J.
SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
Oncogene
19
4290-4297
2000
Rattus norvegicus (O88506), Homo sapiens (Q9UEW8), Mus musculus (Q9Z1W9)
brenda
Miao, N.; Fung, B.; Sanchez, R.; Lydon, J.; Barker, D.; Pang, K.
Isolation and expression of PASK, a serine/threonine kinase, during rat embryonic development, with special emphasis on the pancreas
J. Histochem. Cytochem.
48
1391-1400
2000
Rattus norvegicus (O88506)
brenda
Ushiro, H.; Tsutsumi, T.; Suzuki, K.; Kayahara, T.; Nakano, K.
Molecular cloning and characterization of a novel Ste20-related protein kinase enriched in neurons and transporting epithelia
Arch. Biochem. Biophys.
355
233-240
1998
Rattus norvegicus (O88506)
brenda
Manser, E.; Chong, C.; Zhao, Z.S.; Leung, T.; Michael, G.; Hall, C.; Lim, L.
Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family
J. Biol. Chem.
270
25070-25078
1995
Rattus norvegicus (P35465), Rattus norvegicus (Q62829)
brenda
Manser, E.; Leung, T.; Salihuddin, H.; Zhao, Z.S.; Lim, L.
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
Nature
367
40-46
1994
Rattus norvegicus (P35465)
brenda
Maucuer, A.; Ozon, S.; Manceau, V.; Gavet, O.; Lawler, S.; Curmi, P.; Sobel, A.
KIS is a protein kinase with an RNA recognition motif
J. Biol. Chem.
272
23151-23156
1997
Mus musculus (P97343), Rattus norvegicus (Q63285)
brenda
Alam, M.R.; Caldwell, B.D.; Johnson, R.C.; Darlington, D.N.; Mains, R.E.; Eipper, B.A.
Novel proteins that interact with the COOH-terminal cytosolic routing determinants of an integral membrane peptide-processing enzyme
J. Biol. Chem.
271
28636-28640
1996
Rattus norvegicus (Q63285)
brenda
Ohta, S.; Takeuchi, M.; Deguchi, M.; Tsuji, T.; Gahara, Y.; Nagata, K.
A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway
Biochem. J.
350
395-404
2000
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Rattus norvegicus (P57760)
brenda
Inoue, Y.; Yamamura, H.; Nishizuka, Y.
Protamine kinase independent of adenosine 3,5-monophosphate from rat brain cytosol
Biochem. Biophys. Res. Commun.
50
228-236
1973
Rattus norvegicus
brenda
Langan, T.A.
Action of adenosine 3,5-monophosphate-dependent histone kinase in vivo
J. Biol. Chem.
244
5763-5765
1969
Rattus norvegicus
brenda
Baggio, B.; Pinna, L.A.; Moret, V.; Siliprandi, N.
A simple procedure for the purification of rat liver phosvitin kinase
Biochim. Biophys. Acta
207
515-517
1970
Rattus norvegicus
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brenda
Wang, Z.; Yang, C.L.; Ellison, D.H.
Comparison of WNK4 and WNK1 kinase and inhibiting activities
Biochem. Biophys. Res. Commun.
317
939-944
2004
Rattus norvegicus
brenda
Bain, J.; McLauchlan, H.; Elliott, M.; Cohen, P.
The specificities of protein kinase inhibitors: an update
Biochem. J.
371
199-204
2003
Homo sapiens, Rattus norvegicus
brenda
Vitari, A.C.; Deak, M.; Morrice, N.A.; Alessi, D.R.
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases
Biochem. J.
391
17-24
2005
Rattus norvegicus
brenda
Mukai, H.
The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC
J. Biochem.
133
17-27
2003
Asteroidea, Bos taurus, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis
brenda
Cavet, M.E.; Lehoux, S.; Berk, B.C.
14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity
J. Biol. Chem.
278
18376-18383
2003
Rattus norvegicus
brenda
Liu, S.J.; Zhang, J.Y.; Li, H.L.; Fang, Z.Y.; Wang, Q.; Deng, H.M.; Gong, C.X.; Grundke-Iqbal, I.; Iqbal, K.; Wang, J.Z.
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain
J. Biol. Chem.
279
50078-50088
2004
Rattus norvegicus
brenda
Zhao, X.; Zhuang, S.; Chen, Y.; Boss, G.R.; Pilz, R.B.
Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3
J. Biol. Chem.
280
32683-32692
2005
Rattus norvegicus
brenda
Coito, C.; Diamond, D.L.; Neddermann, P.; Korth, M.J.; Katze, M.G.
High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein
J. Virol.
78
3502-3513
2004
Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus
brenda
Takano, A.; Hoe, H.S.; Isojima, Y.; Nagai, K.
Analysis of the expression, localization and activity of rat casein kinase 1epsilon-3
NeuroReport
15
1461-1464
2004
Rattus norvegicus (Q99PS2), Rattus norvegicus (Q9JJ75), Rattus norvegicus (Q9JJ76)
brenda
Yano, R.; Yap, C.C.; Yamazaki, Y.; Muto, Y.; Kishida, H.; Okada, D.; Hashikawa, T.
Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions
Neuroscience
117
373-381
2003
Rattus norvegicus
brenda
Min, X.; Lee, B.H.; Cobb, M.H.; Goldsmith, E.J.
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
Structure
12
1303-1311
2004
Rattus norvegicus
brenda
Chao, C.C.; Ma, Y.L.; Lee, E.H.
Protein kinase CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling: activation of Akt and inactivation of SGK1
J. Neurosci.
27
6243-6248
2007
Rattus norvegicus
brenda
Rafacho, A.; Ribeiro, D.L.; Boschero, A.C.; Taboga, S.R.; Bosqueiro, J.R.
Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats
Int. J. Exp. Pathol.
89
264-275
2008
Rattus norvegicus
brenda
Mao, K.; Kobayashi, S.; Jaffer, Z.M.; Huang, Y.; Volden, P.; Chernoff, J.; Liang, Q.
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes
J. Mol. Cell. Cardiol.
44
429-434
2008
Mus musculus (P07564), Rattus norvegicus (P35465)
brenda
Kanan, Y.; Matsumoto, H.; Song, H.; Sokolov, M.; Anderson, R.; Rajala, R.
Serine/threonine kinase Akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL
J. Neurochem.
113
477-488
2010
Rattus norvegicus
brenda
Sahu, A.; Koshinaka, K.; Sahu, M.
Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus
J. Neuroendocrinol.
25
168-179
2013
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Dong, Q.; Giorgianni, F.; Beranova-Giorgianni, S.; Deng, X.; OMeally, R.; Bridges, D.; Park, E.; Cole, R.; Elam, M.; Raghow, R.
Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation
Biosci. Rep.
36
e00284
2016
Rattus norvegicus (P18266)
brenda
Schael, S.; Nuechel, J.; Mueller, S.; Petermann, P.; Kormann, J.; Perez-Otano, I.; Martinez, S.; Paulsson, M.; Plomann, M.
Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation
J. Biol. Chem.
288
9303-9312
2013
Mus musculus (O54833), Rattus norvegicus (P19139)
-
brenda