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Information on EC 2.7.11.1 - non-specific serine/threonine protein kinase and Organism(s) Drosophila melanogaster and UniProt Accession P54367

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IUBMB Comments
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
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This record set is specific for:
Drosophila melanogaster
UNIPROT: P54367
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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ATP
+
a [protein]-(L-serine/L-threonine)
=
ADP
+
a [protein]-(L-serine/L-threonine) phosphate
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase a, 14-3-3, camkii, p-akt, lrrk2, c-jun n-terminal kinase, serine/threonine kinase, raf-1, protein kinase b, gsk-3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
casein kinase I, alpha isoform
-
A-kinase
-
-
-
-
A-T, mutated
-
-
-
-
A-T, mutated homolog
-
-
-
-
AMH type II receptor
-
-
-
-
Anti-sigma B factor rsbT
-
-
-
-
AP50 kinase
-
-
-
-
Ataxia telangiectasia mutated
-
-
-
-
Ataxia telangiectasia mutated homolog
-
-
-
-
ATP-protein transphosphorylase
-
-
-
-
betaIIPKC
-
-
-
-
Breast-tumor-amplified kinase
-
-
-
-
Calcium-dependent protein kinase C
-
-
-
-
Calcium/phospholipid-dependent protein kinase
-
-
-
-
cAMP-dependent protein kinase A
-
-
-
-
casein kinase
-
-
-
-
casein kinase 2
-
-
-
-
casein kinase I
casein kinase Iepsilon
-
casein kinase II
casein kinase-2
-
-
-
-
CDC25 suppressing protein kinase
-
-
-
-
Cell division cycle 2-like
-
-
-
-
CK-2
-
-
-
-
CK2
-
-
-
-
CK2-alpha
-
-
-
-
CKI
-
-
-
-
CKII
-
-
-
-
CLP-36 interacting kinase
-
-
-
-
cyclic monophosphate-dependent protein kinase
-
-
-
-
cyclic nucleotide-dependent protein kinase
-
-
-
-
cyclin-dependent kinase
-
-
-
-
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
-
-
-
-
discs overgrown protein kinase
-
DNA-PKcs
-
-
-
-
DNPK1
-
-
-
-
dSTPK61
-
-
-
-
G11 protein
-
-
-
-
hARK1
-
-
-
-
histone kinase
-
-
-
-
hPDK1
-
-
-
-
Hpr kinase
-
-
-
-
hPSK
-
-
-
-
HSPK 21
-
-
-
-
HSPK 36
-
-
-
-
hydroxyalkyl-protein kinase
-
-
-
-
Kinase interacting with stathmin
-
-
-
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kinase, casein (phosphorylating)
-
-
-
-
kinase, protamine (phosphorylating)
-
-
-
-
kinase, protein (phosphorylating)
-
-
-
-
kinase, protein, A (phosphorylating)
-
-
-
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kinase, protein, C (phosphorylating)
-
-
-
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Lymphocyte-oriented kinase
-
-
-
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M phase-specific cdc2 kinase
-
-
-
-
MAP kinase-activated protein kinase 2
-
MAPK-activated protein kinase-2
-
mitogen-activated S6 kinase
-
-
-
-
mPDK1
-
-
-
-
MPSK
-
-
-
-
Myristoylated and palmitoylated serine-threonine kinase
-
-
-
-
NY-REN-55 antigen
-
-
-
-
ovarian-specific serine/threonine-protein kinase Lok
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P-CIP2
-
-
-
-
P460
-
-
-
-
p46Eg265
-
-
-
-
p46XlEg22
-
-
-
-
p82 kinase
-
-
-
-
pEg2
-
-
-
-
phosphorylase b kinase kinase
-
-
-
-
Phototropin
-
-
-
-
Pim-2h
-
-
-
-
PKA
-
-
-
-
PkB kinase
-
-
-
-
pp39-mos
-
-
-
-
Pre-mRNA protein kinase
-
-
-
-
protamine kinase
-
-
-
-
protein glutamyl kinase
-
-
-
-
protein kinase (phosphorylating)
-
-
-
-
Protein kinase B kinase
-
-
-
-
protein kinase CK2
-
-
-
-
protein kinase DC1
-
protein kinase DC2
-
protein kinase Doa
-
Protein kinase Krct
-
-
-
-
Protein kinase MST
-
-
-
-
protein kinase p58
-
-
-
-
Protein kinase PKL12
-
-
-
-
protein phosphokinase
-
-
-
-
protein serine kinase
-
-
-
-
protein serine-threonine kinase
-
-
-
-
protein-aspartyl kinase
-
-
-
-
protein-cysteine kinase
-
-
-
-
protein-serine kinase
-
-
-
-
protein-serine/threonine kinase
-
-
-
-
PRP4 kinase
-
-
-
-
PRP4 pre-mRNA processing factor 4 homolog
-
-
-
-
PSK-H1
-
-
-
-
Raf kinase
-
-
-
-
Raf-1
-
-
-
-
ratAurA
-
-
-
-
ribosomal protein S6 kinase II
-
-
-
-
ribosomal S6 protein kinase
-
-
-
-
RP1 protein
-
-
-
-
S-receptor kinase
-
-
-
-
serine kinase
-
-
-
-
serine protein kinase
-
-
-
-
serine(threonine) protein kinase
-
-
-
-
serine-specific protein kinase
-
-
-
-
serine/threonine kinase
-
-
-
-
Serine/threonine kinase 15
-
-
-
-
Serine/threonine kinase Ayk1
-
-
-
-
serine/threonine protein kinase
-
-
-
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serine/threonine-protein kinase fused
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Serine/threonine-protein kinase NRK2
-
-
-
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Serine/threonine-protein kinase NYD-SPK
-
-
-
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serine/threonine-protein kinase Pk61C
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SRK
-
-
-
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Ste20-like kinase
-
-
-
-
STE20-like kinase MST1
-
-
-
-
STE20-like kinase MST2
-
-
-
-
STE20-like kinase MST3
-
-
-
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Switch protein/serine kinase
-
-
-
-
T-antigen kinase
-
-
-
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threonine-specific protein kinase
-
-
-
-
Twitchin kinase
-
-
-
-
type-2 casein kinase
-
-
-
-
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
show the reaction diagram
catalytic mechanism and regulation of PKN
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (non-specific)
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
CAS REGISTRY NUMBER
COMMENTARY hide
191808-15-8
phosphoinositide dependent protein kinase 1
340830-03-7
-
37278-10-7
-
377752-08-4
ribosomal protein S6 kinase 2
389133-24-8
ribosomal S6 kinase 3
52660-18-1
casein kinase, protein kinase CK2
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
90698-26-3
ribosomal protein S6 kinase 1
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
casein kinase 1 alpha gene is developmentally regulated and the kinase activity of the protein is induced by DNA damage. Possible requirement in mechanisms associated with DNA repair during early embryogenesis
-
-
?
ATP + adenomatous polyposis coli protein
ADP + phosphorylated adenomatous polyposis coli protein
show the reaction diagram
-
i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
-
phosphorylation at Ser45, priming GSK3beta phosphorylation
-
-
?
ATP + protein Cubitus interruptus
ADP + phosphorylated protein Cubitus interruptus
show the reaction diagram
ATP + protein LRP6
ADP + phosphorylated protein LRP6
show the reaction diagram
-
CKIgamma
-
-
?
ATP + protein TCF3
ADP + phosphorylated protein TCF3
show the reaction diagram
-
CKIepsilon
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
enzyme is essential for eye and embryonic development
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
casein kinase 1 alpha gene is developmentally regulated and the kinase activity of the protein is induced by DNA damage. Possible requirement in mechanisms associated with DNA repair during early embryogenesis
-
-
?
ATP + adenomatous polyposis coli protein
ADP + phosphorylated adenomatous polyposis coli protein
show the reaction diagram
-
i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
-
phosphorylation at Ser45, priming GSK3beta phosphorylation
-
-
?
ATP + protein Cubitus interruptus
ADP + phosphorylated protein Cubitus interruptus
show the reaction diagram
-
Ci proteins are important in regulation of Hedgehog signaling, overview
-
-
?
ATP + protein LRP6
ADP + phosphorylated protein LRP6
show the reaction diagram
-
CKIgamma
-
-
?
ATP + protein TCF3
ADP + phosphorylated protein TCF3
show the reaction diagram
-
CKIepsilon
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
enzyme is essential for eye and embryonic development
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
PKN possesses an autoinhibitory site at the C-terminal C2 domain, which also binds activating arachidonic acid
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
arachidonic acid
-
activates in vitro, binds at the autoinhibitory site at the C-terminal C2-domain
Rac1
-
GTPase, binds and activates PKN
-
Rac2
-
GTPase, binds and activates PKN
-
Rho1
-
small GTPase, binds GTP-dependently and activates PKN
-
RhoA
-
small GTPase, binds to the ACC domain of PKNalpha forming a catalytic active site
additional information
-
phosphorylation of PKN is required for full activation
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
present during early embryogenesis
Manually annotated by BRENDA team
at early cleavage-stages Dmnk transcripts are transiently present throughout the embryo, but become restricted to the posterior pole and then to the newly-formed primordial germ cells by the blastoderm stage. The transcripts are sustained in the pole cells during gastrulation
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
localized to the nuclei in a speckled pattern. Dmnk proteins become detectable in both somatic and germ line cell nuclei upon their arrival at the periplasm of the syncytial embryo, but then disappear from the somatic cell nuclei. Consistent with mRNA expression, Dmnk proteins in pole cell nuclei are sustained during gastrulation
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KC1A_DROME
337
0
39535
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
24700
alphaxbetax, x * 39833 + x * 24700, calculation from nucleotide sequence
39833
alphaxbetax, x * 39833 + x * 24700, calculation from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
alphaxbetax, x * 39833 + x * 24700, calculation from nucleotide sequence
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D173N
-
the dominant-negative form of CKIgamma inhibits Wnt signaling in a reporter assay in 293T cells, and gish RNAi partially blocks transcription induced by Wg in SL2 cells
K73R
-
the dominant-negative form of CKIgamma inhibits Wnt signaling in a reporter assay in 293T cells, and gish RNAi partially blocks transcription induced by Wg in SL2 cells
additional information
dbtS and dbtL mutations, which alter period length of Drosophila circadian rhythms, produce single amino acid changes in conserved regions of the predicted kinase
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
alpha-subunit and beta-subunit
overexpression of CKI in Drosophila Kc cell line, the sole Drosophila CKIdelta/epsilon gene, but not CKIalpha, activates a wingless transcriptional reporter in the absence of ligand
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (O61267), Drosophila melanogaster (P08181), Drosophila melanogaster (P23647), Drosophila melanogaster (P49071), Drosophila melanogaster (P54367), Drosophila melanogaster (Q9W0V1)
Manually annotated by BRENDA team
Kalderon, D.; Rubin, G.M.
Isolation and characterization of Drosophila cAMP-dependent protein kinase genes
Genes Dev.
2
1539-1556
1988
Drosophila melanogaster (P16911), Drosophila melanogaster (P16912)
Manually annotated by BRENDA team
Alessi, D.R.; Deak, M.; Casamayor, A.; Caudwell, F.B.; Morrice, N.; Norman, D.G.; Gaffney, P.; Reese, C.B.; MacDougall, C.N.; Harbison, D.; Ashworth, A.; Bownes, M.
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
Curr. Biol.
7
776-789
1997
Drosophila melanogaster (Q9W0V1)
Manually annotated by BRENDA team
Oishi, I.; Sugiyama, S.; Otani, H.; Yamamura, H.; Nishida, Y.; Minami, Y.
A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment
Mech. Dev.
71
49-63
1998
Drosophila melanogaster (O61267)
Manually annotated by BRENDA team
Therond, P.; Busson, D.; Guillemet, E.; Limbourg-Bouchon, B.; Preat, T.; Terracol, R.; Tricoire, H.; Lamour-Isnard, C.
Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster
Mech. Dev.
44
65-80
1993
Drosophila melanogaster (P23647)
Manually annotated by BRENDA team
Preat, T.; Therond, P.; Limbourg-Bouchon, B.; Pham, A.; Tricoire, H.; Busson, D.; Lamour-Isnard, C.
Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2
Genetics
135
1047-1062
1993
Drosophila melanogaster (P23647), Drosophila melanogaster
Manually annotated by BRENDA team
Preat, T.; Therond, P.; Lamour-Isnard, C.; Limbourg-Bouchon, B.; Tricoire, H.; Erk, I.; Mariol, M.C.; Busson, D.
A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila
Nature
347
87-89
1990
Drosophila melanogaster (P23647)
Manually annotated by BRENDA team
Larochelle, S.; Suter, B.
The Drosophila melanogaster homolog of the mammalian MAPK-activated protein kinase-2 (MAPKAPK-2) lacks a proline-rich N-terminus
Gene
163
209-214
1995
Drosophila melanogaster (P49071), Drosophila melanogaster
Manually annotated by BRENDA team
Kloss, B.; Price, J.L.; Saez, L.; Blau, J.; Rothenfluh, A.; Wesley, C.S.; Young, M.W.
The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon
Cell
94
97-107
1998
Drosophila melanogaster (O76324)
Manually annotated by BRENDA team
Price, J.L.; Blau, J.; Rothenfluh, A.; Abodeely, M.; Kloss, B.; Young, M.W.
Double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
Cell
94
83-95
1998
Drosophila melanogaster (O76324)
Manually annotated by BRENDA team
Santos, J.A.; Logarinho, E.; Tapia, C.; Allende, C.C.; Allende, J.E.; Sunkel, C.E.
The casein kinase 1 alpha gene of Drosophila melanogaster is developmentally regulated and the kinase activity of the protein induced by DNA damage
J. Cell Sci.
109
1847-1856
1996
Drosophila melanogaster (P54367)
-
Manually annotated by BRENDA team
Padmanabha, R.; Glover, C.V.
Casein kinase II of yeast contains two distinct alpha polypeptides and an unusually large beta subunit
J. Biol. Chem.
262
1829-1835
1987
Drosophila melanogaster (P08181), Saccharomyces cerevisiae (P15790), Saccharomyces cerevisiae (P19454), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Saxena, A.; Padmanabha, R.; Glover, C.V.
Isolation and sequencing of cDNA clones encoding alpha and beta subunits of Drosophila melanogaster casein kinase II
Mol. Cell. Biol.
7
3409-3417
1987
Drosophila melanogaster (P08181), Drosophila melanogaster
Manually annotated by BRENDA team
Yun, B.; Farkas, R.; Lee, K.; Rabinow, L.
The Doa locus encodes a member of a new protein kinase family and is essential for eye and embryonic development in Drosophila melanogaster
Genes Dev.
8
1160-1173
1994
Drosophila melanogaster (P49762), Drosophila melanogaster
Manually annotated by BRENDA team
Mukai, H.
The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC
J. Biochem.
133
17-27
2003
Asteroidea, Bos taurus, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis
Manually annotated by BRENDA team
Price, M.A.
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling
Genes Dev.
20
399-410
2006
Drosophila melanogaster, Homo sapiens, Xenopus laevis
Manually annotated by BRENDA team