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Information on EC 2.7.11.1 - non-specific serine/threonine protein kinase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P08458

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IUBMB Comments
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
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Saccharomyces cerevisiae
UNIPROT: P08458
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Word Map
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase a, 14-3-3, camkii, p-akt, lrrk2, c-jun n-terminal kinase, serine/threonine kinase, raf-1, protein kinase b, gsk-3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sporulation-specific protein 1
-
A-kinase
-
-
-
-
A-T, mutated
-
-
-
-
A-T, mutated homolog
-
-
-
-
AMH type II receptor
-
-
-
-
Anti-sigma B factor rsbT
-
-
-
-
AP50 kinase
-
-
-
-
Ataxia telangiectasia mutated
-
-
-
-
Ataxia telangiectasia mutated homolog
-
-
-
-
ATP-protein transphosphorylase
-
-
-
-
autophagy serine/threonine-protein kinase APG1
-
betaIIPKC
-
-
-
-
Breast-tumor-amplified kinase
-
-
-
-
Calcium-dependent protein kinase C
-
-
-
-
Calcium/phospholipid-dependent protein kinase
-
-
-
-
cAMP-dependent protein kinase A
-
-
-
-
carbon catabolite derepressing protein kinase
-
casein kinase
casein kinase 2
-
-
-
-
casein kinase I
-
-
-
-
casein kinase I homolog 1
-
casein kinase I homolog 2
-
casein kinase I homolog 3
-
casein kinase I homolog HRR25
-
casein kinase II
casein kinase-2
-
-
-
-
CDC25 suppressing protein kinase
-
-
-
-
cell cycle protein kinase DBF2
-
cell division control protein 15
-
cell division control protein 7
-
Cell division cycle 2-like
-
-
-
-
checkpoint serine/threonine-protein kinase bub1
-
CK-2
-
-
-
-
CK2
-
-
-
-
CK2-alpha
-
-
-
-
CKI
-
-
-
-
CLP-36 interacting kinase
-
-
-
-
cyclic monophosphate-dependent protein kinase
-
-
-
-
cyclic nucleotide-dependent protein kinase
-
-
-
-
cyclin-dependent kinase
-
-
-
-
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
-
-
-
-
DNA damage response protein kinase DUN1
-
DNA-PKcs
-
-
-
-
DNPK1
-
-
-
-
dSTPK61
-
-
-
-
G11 protein
-
-
-
-
Gin4p protein kinase
-
Glc7
-
catalytic subunit of protein phosphatase 1
hARK1
-
-
-
-
histone kinase
-
-
-
-
hPDK1
-
-
-
-
Hpr kinase
-
-
-
-
hPSK
-
-
-
-
HSPK 21
-
-
-
-
HSPK 36
-
-
-
-
hydroxyalkyl-protein kinase
-
-
-
-
IpL1protein kinase
-
Kinase interacting with stathmin
-
-
-
-
kinase, casein (phosphorylating)
-
-
-
-
kinase, protamine (phosphorylating)
-
-
-
-
kinase, protein (phosphorylating)
-
-
-
-
kinase, protein, A (phosphorylating)
-
-
-
-
kinase, protein, C (phosphorylating)
-
-
-
-
Lymphocyte-oriented kinase
-
-
-
-
M phase-specific cdc2 kinase
-
-
-
-
meiosis-specific serine/threonine-protein kinase MEK1
-
mitogen-activated S6 kinase
-
-
-
-
mPDK1
-
-
-
-
MPSK
-
-
-
-
Myristoylated and palmitoylated serine-threonine kinase
-
-
-
-
nitrogen permease reactivator protein
-
NY-REN-55 antigen
-
-
-
-
P-CIP2
-
-
-
-
P460
-
-
-
-
p46Eg265
-
-
-
-
p46XlEg22
-
-
-
-
p82 kinase
-
-
-
-
pEg2
-
-
-
-
phosphorylase b kinase kinase
-
-
-
-
Phototropin
-
-
-
-
Pim-2h
-
-
-
-
PKA
-
-
-
-
PkB kinase
-
-
-
-
pp39-mos
-
-
-
-
Pre-mRNA protein kinase
-
-
-
-
protamine kinase
-
-
-
-
protein glutamyl kinase
-
-
-
-
protein kinase (phosphorylating)
-
-
-
-
Protein kinase B kinase
-
-
-
-
protein kinase Cbk1p
-
protein kinase CK2
-
-
-
-
protein kinase DBF20
-
Protein kinase Krct
-
-
-
-
Protein kinase MST
-
-
-
-
protein kinase p58
-
-
-
-
Protein kinase PKL12
-
-
-
-
protein kinase Rim15p
-
protein phosphokinase
-
-
-
-
protein serine kinase
-
-
-
-
protein serine-threonine kinase
-
-
-
-
protein-aspartyl kinase
-
-
-
-
protein-cysteine kinase
-
-
-
-
protein-serine kinase
-
-
-
-
protein-serine/threonine kinase
-
-
-
-
PRP4 kinase
-
-
-
-
PRP4 pre-mRNA processing factor 4 homolog
-
-
-
-
PSK-H1
-
-
-
-
Raf kinase
-
-
-
-
Raf-1
-
-
-
-
ratAurA
-
-
-
-
ribosomal protein S6 kinase II
-
-
-
-
ribosomal S6 protein kinase
-
-
-
-
RP1 protein
-
-
-
-
S-receptor kinase
-
-
-
-
serine kinase
-
-
-
-
serine protein kinase
-
-
-
-
serine(threonine) protein kinase
-
-
-
-
serine-specific protein kinase
-
-
-
-
serine/threonine kinase
Serine/threonine kinase 15
-
-
-
-
Serine/threonine kinase Ayk1
-
-
-
-
serine/threonine protein kinase
-
-
-
-
serine/threonine protein kinase BUD32
-
serine/threonine-protein kinase CBK1
-
serine/threonine-protein kinase Chk1
-
serine/threonine-protein kinase CLA4
-
serine/threonine-protein kinase GIN4
-
serine/threonine-protein kinase IPL1
-
serine/threonine-protein kinase IRE1 precursor
-
serine/threonine-protein kinase KIN3
-
serine/threonine-protein kinase KIN4
-
serine/threonine-protein kinase KSP1
-
Serine/threonine-protein kinase NRK2
-
-
-
-
Serine/threonine-protein kinase NYD-SPK
-
-
-
-
serine/threonine-protein kinase PAK1
-
serine/threonine-protein kinase PTK1/STK1
-
serine/threonine-protein kinase PTK2/STK2
-
serine/threonine-protein kinase RCK1
-
serine/threonine-protein kinase RCK2
-
serine/threonine-protein kinase RIM15
-
serine/threonine-protein kinase SAT4
-
serine/threonine-protein kinase SCH9
-
serine/threonine-protein kinase SKM1
-
serine/threonine-protein kinase SKS1
-
serine/threonine-protein kinase STE20
-
serine/threonine-protein kinase YPK1
-
serine/threonine-protein kinase YPK2/YKR2
-
SRK
-
-
-
-
Ste20-like kinase
-
-
-
-
STE20-like kinase MST1
-
-
-
-
STE20-like kinase MST2
-
-
-
-
STE20-like kinase MST3
-
-
-
-
Switch protein/serine kinase
-
-
-
-
T-antigen kinase
-
-
-
-
threonine-specific protein kinase
-
-
-
-
Twitchin kinase
-
-
-
-
type-2 casein kinase
-
-
-
-
Yck1 casein kinase I
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (non-specific)
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
CAS REGISTRY NUMBER
COMMENTARY hide
191808-15-8
phosphoinositide dependent protein kinase 1
340830-03-7
-
37278-10-7
-
377752-08-4
ribosomal protein S6 kinase 2
389133-24-8
ribosomal S6 kinase 3
52660-18-1
casein kinase, protein kinase CK2
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
90698-26-3
ribosomal protein S6 kinase 1
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + beta-casein
ADP + phosphorylated beta-casein
show the reaction diagram
-
-
-
-
?
ATP + Bub3
ADP + phosphorylated Bub3
show the reaction diagram
-
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
ATP + Cdc28-cyclin B
ADP + phospho-Cdc28-cyclin B
show the reaction diagram
-
-
-
-
?
ATP + FACT
ADP + phospho-FACT
show the reaction diagram
-
the FACT complex can be phosphorylated in vitro in reactions containing recombinant CKII
-
-
?
ATP + histine H2A
ADP + histidine gammaH2A
show the reaction diagram
-
phosphorylation on serine 129 in vivo
Glc7 dephosphorylates histidine gammaH2A in vitro
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
-
-
-
-
?
ATP + histone H2B
ADP + phosphorylated histone H2B
show the reaction diagram
-
-
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
-
-
-
-
?
ATP + NS5A protein
ADP + phosphorylated NS5A protein
show the reaction diagram
-
recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by diverse serine/threonine protein kinases, phosphorylation patterns, overview
-
-
?
ATP + PAF-C
ADP + phospho-PAF-C
show the reaction diagram
ATP + PAF-C protein
ADP + phosphorylated PAF-C protein
show the reaction diagram
-
-
-
-
?
ATP + Pah1
ADP + phospho-Pah1
show the reaction diagram
ATP + Pah1 phosphatidate phosphatase
ADP + phosphorylated Pah1 phosphatidate phosphatase
show the reaction diagram
ATP + Pho85-Pho80
ADP + phospho-Pho85-Pho80
show the reaction diagram
-
-
-
-
?
ATP + protamine
ADP + O-phosphoprotamine
show the reaction diagram
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein kinase A
ADP + phospho-protein kinase A
show the reaction diagram
-
-
-
-
?
ATP + protein kinase C
ADP + phospho-protein kinase C
show the reaction diagram
-
-
-
-
?
ATP + Sec2p
ADP + phospho-Sec2p
show the reaction diagram
ATP + Sec2p protein
ADP + phosphorylated Sec2p protein
show the reaction diagram
-
enzymesYck1p and Yck2p target phosphosites within the Sec15p/Ypt32p binding region of Sec2p protein
-
-
?
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + histine H2A
ADP + histidine gammaH2A
show the reaction diagram
-
phosphorylation on serine 129 in vivo
Glc7 dephosphorylates histidine gammaH2A in vitro
-
?
ATP + PAF-C
ADP + phospho-PAF-C
show the reaction diagram
-
all five subunits of PAF-C are putative CKII targets, PAF-C and CKII are direct interacting partners, overview
-
-
?
ATP + PAF-C protein
ADP + phosphorylated PAF-C protein
show the reaction diagram
-
-
-
-
?
ATP + Pah1
ADP + phospho-Pah1
show the reaction diagram
-
Pah1 is a bona fide substrate of yeast CKII. Enzyme CKII phosphorylates Pah1 on Thr170, Ser250, Ser313, Ser705, Ser814, and Ser818
-
-
?
ATP + Pah1 phosphatidate phosphatase
ADP + phosphorylated Pah1 phosphatidate phosphatase
show the reaction diagram
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + Sec2p
ADP + phospho-Sec2p
show the reaction diagram
-
-
-
-
?
ATP + Sec2p protein
ADP + phosphorylated Sec2p protein
show the reaction diagram
-
enzymesYck1p and Yck2p target phosphosites within the Sec15p/Ypt32p binding region of Sec2p protein
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
requirement, 1-10 mM, can replace Mg2+ to some extent, inhibits above 30 mM
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Co2+
-
above 30 mM, activating below 20 mM
Mg2+
-
above 30 mM, activating below 20 mM
Mn2+
-
above 30 mM, activating below 20 mM
phosphatidylinositol-4-phosphate
-
inhibits Sec2p phosphorylation by Yck2p
additional information
-
Sec2p phosphorylation is affected in Pik1p and Sac1p mutants
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
FACT
-
may facilitate CKII recruitment to PAF-C for its subsequent phosphorylation
-
additional information
-
D-glucose pro­motes Sec2p phosphorylation
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0024 - 0.0055
ATP
0.00021 - 0.00023
Pah1 phosphatidate phosphatase
-
additional information
additional information
-
saturation kinetics with respect to the concentrations of Pah1 and ATP
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
actively expressed in mitotically dividing cells
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
at late endosome and vacuole interface
Manually annotated by BRENDA team
-
excessive overexpression of GFP-tagged Env7 leads to additional localization to the Golgi apparatus
Manually annotated by BRENDA team
glycosylated N-terminal portion is located inside microsomes
-
Manually annotated by BRENDA team
-
at late endosome and vacuole interface, GFP- and HA-tagged recombinant Env7s are vacuolar membrane proteins
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
gene ENV7 is a widely conserved orthologue of the serine/threonine kinase 16 (STK16) gene, phylogenetic anaysis
malfunction
metabolism
physiological function
additional information
-
the enzyme's N-terminal Cys13 to -15 track is essential for Env7 vacuolar membrane anchoring and kinase activity
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
126983
x * 126983, calculation from nucleotide sequence
30000
-
gel filtration
42000
-
x * 42000, about, His6-tagged enzyme, SDS-PAGE
86000
x * 86000, calculation from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lipoprotein
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C13S/C14S/C15S
-
site-directed mutagenesis
E269A
-
site-directed mutagenesis, the mutant is degraded in a proteasome-dependent manner, its kinase function is abolished when stabilized
E269D
-
site-directed mutagenesis
E269S
-
site-directed mutagenesis
H187Y
-
a dead kinase allele, inactive Yck2p mutant
K69R/K70M
-
site-directed mutagenesis
K69R/K70R
-
site-directed mutagenesis
additional information
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
at 50°C, t1/2: 10 min
645084
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
-
at pH 7.5, t1/2: 10 min
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, at least 2 months
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
IgG-Sepharose affinity column chromatography
-
recombinant His6-tagged Env7 from Escherichia coli strain BL21(DE3)(pLysS) by nickel affinity chromatography
-
recombinant N-terminally GST-tagged enzyme from Escherichia coli by glutathione affinity chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
gene ENV7, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression of His6-tagged Env7 in Escherichia coli strain BL21(DE3)(pLysS), functional expression of HA- and GFP-tagged Env7 and overexpression of wild-type untagged Env7 in yeast cells. HA- and GFP-tagged Env7 localize to vacuolar membranes, and
-
isolation of the alpha subunit of casein kinase II
recombinant expression of N-terminally GST-tagged enzyme in Escherichia coli
-
recombinant expression of N-terminally GST-tagged enzyme in Escherichia coli, overexpression of GFP-tagged Yck2p wild-type and mutant enzymes in Saccharomyces cerevisiae
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
di Blasi, F.; Carra, E.; de Vendittis, E.; Masturzo, P.; Burderi, E.; Lambrinoudaki, I.; Mirisola, M.G.; Seidita, G.; Fasano, O.
The SCH9 protein kinase mRNA contains a long 5' leader with a small open reading frame
Yeast
9
21-32
1993
Saccharomyces cerevisiae (P11792)
Manually annotated by BRENDA team
Johnston, M.; Andrews, S.; Brinkman, R.; Cooper, J.; Ding, H.; Dover, J.; Du, Z.; Favello, A.; Fulton, L.; Gattung, S.; et al.
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII
Science
265
2077-2082
1994
Saccharomyces cerevisiae (P11792), Saccharomyces cerevisiae (P23291), Saccharomyces cerevisiae (P23292), Saccharomyces cerevisiae (P32361), Saccharomyces cerevisiae (P38691), Saccharomyces cerevisiae (Q03497)
Manually annotated by BRENDA team
Toda, T.; Cameron, S.; Sass, P.; Wigler, M.
SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits
Genes Dev.
2
517-527
1988
Saccharomyces cerevisiae (P11792)
Manually annotated by BRENDA team
Chen, P.; Lee, K.S.; Levin, D.E.
A pair of putative protein kinase genes (YPK1 and YPK2) is required for cell growth in Saccharomyces cerevisiae
Mol. Gen. Genet.
236
443-447
1993
Saccharomyces cerevisiae (P12688), Saccharomyces cerevisiae (P18961)
Manually annotated by BRENDA team
Maurer, R.A.
Isolation of a yeast protein kinase gene by screening with a mammalian protein kinase cDNA
DNA
7
469-474
1988
Saccharomyces cerevisiae (P12688)
Manually annotated by BRENDA team
Kubo, K.; Ohno, S.; Matsumoto, S.; Yahara, I.; Suzuki, K.
A novel yeast gene coding for a putative protein kinase
Gene
76
177-180
1989
Saccharomyces cerevisiae (P18961)
Manually annotated by BRENDA team
Toyn, J.H.; Araki, H.; Sugino, A.; Johnston, L.H.
The cell-cycle-regulated budding yeast gene DBF2, encoding a putative protein kinase, has a homologue that is not under cell-cycle control
Gene
104
63-70
1991
Saccharomyces cerevisiae (P22204), Saccharomyces cerevisiae (P32328)
Manually annotated by BRENDA team
Johnston, L.H.; Eberly, S.L.; Chapman, J.W.; Araki, H.; Sugino, A.
The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle
Mol. Cell. Biol.
10
1358-1366
1990
Saccharomyces cerevisiae (P22204)
Manually annotated by BRENDA team
Leem, S.H.; Ogawa, H.
The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae
Nucleic Acids Res.
20
449-457
1992
Saccharomyces cerevisiae (P24719)
Manually annotated by BRENDA team
Purnelle, B.; Goffeau, A.
Nucleotide sequence analysis of a 40 kb segment on the right arm of yeast chromosome XV reveals 18 open reading frames including a new pyruvate kinase and three homologues to chromosome I genes
Yeast
12
1475-1481
1996
Saccharomyces cerevisiae (P24719)
Manually annotated by BRENDA team
Rockmill, B.; Roeder, G.S.
A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination
Genes Dev.
5
2392-2404
1991
Saccharomyces cerevisiae (P24719)
Manually annotated by BRENDA team
Francisco, L.; Wang, W.; Chan, C.S.
Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation
Mol. Cell. Biol.
14
4731-4740
1994
Saccharomyces cerevisiae (P38991)
Manually annotated by BRENDA team
Mitchelhill, K.I.; Stapleton, D.; Gao, G.; House, C.; Michell, B.; Katsis, F.; Witters, L.A.; Kemp, B.E.
Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
J. Biol. Chem.
269
2361-2364
1994
Saccharomyces cerevisiae (P06782)
Manually annotated by BRENDA team
Celenza, J.L.; Carlson, M.
A yeast gene that is essential for release from glucose repression encodes a protein kinase
Science
233
1175-1180
1986
Saccharomyces cerevisiae (P06782)
Manually annotated by BRENDA team
Levin, D.E.; Hammond, C.I.; Ralston, R.O.; Bishop, J.M.
Two yeast genes that encode unusual protein kinases
Proc. Natl. Acad. Sci. USA
84
6035-6039
1987
Saccharomyces cerevisiae (P13185), Saccharomyces cerevisiae (P13186)
Manually annotated by BRENDA team
Sanchez, Y.; Bachant, J.; Wang, H.; Hu, F.; Liu, D.; Tetzlaff, M.; Elledge, S.J.
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
Science
286
1166-1171
1999
Saccharomyces cerevisiae (P38147)
Manually annotated by BRENDA team
James, C.M.; Indge, K.J.; Oliver, S.G.
DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43
Yeast
11
1413-1419
1995
Saccharomyces cerevisiae (P38622)
Manually annotated by BRENDA team
Dahlkvist, A.; Sunnerhagen, P.
Two novel deduced serine/threonine protein kinases from Saccharomyces cerevisiae
Gene
139
27-33
1994
Saccharomyces cerevisiae (P38622), Saccharomyces cerevisiae (P38623)
Manually annotated by BRENDA team
Melcher, M.L.; Thorner, J.
Identification and characterization of the CLK1 gene product, a novel CaM kinase-like protein kinase from the yeast Saccharomyces cerevisiae
J. Biol. Chem.
271
29958-29968
1996
Saccharomyces cerevisiae (P38623)
Manually annotated by BRENDA team
Hovland, P.G.; Tecklenberg, M.; Sclafani, R.A.
Overexpression of the protein kinase Pak1 suppresses yeast DNA polymerase mutations
Mol. Gen. Genet.
256
45-53
1997
Saccharomyces cerevisiae (P38990)
Manually annotated by BRENDA team
Saiz, J.E.; Buitrago, M.J.; Garcia, R.; Revuelta, J.L.; Del Rey, F.
The sequence of a 20.3 kb DNA fragment from the left arm of Saccharomyces cerevisiae chromosome IV contains the KIN28, MSS2, PHO2, POL3 and DUN1 genes, and six new open reading frames
Yeast
12
1077-1084
1996
Saccharomyces cerevisiae (P39009)
Manually annotated by BRENDA team
Boskovic, J.; Soler-Mira, A.; Garcia-Cantalejo, J.M.; Ballesta, J.P.; Jimenez, A.; Remacha, M.
The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames
Yeast
12
1377-1384
1996
Saccharomyces cerevisiae (P39009)
Manually annotated by BRENDA team
Zhou, Z.; Elledge, S.J.
DUN1 encodes a protein kinase that controls the DNA damage response in yeast
Cell
75
1119-1127
1993
Saccharomyces cerevisiae (P39009)
Manually annotated by BRENDA team
Matsuura, A.; Tsukada, M.; Wada, Y.; Ohsumi, Y.
Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
Gene
192
245-250
1997
Saccharomyces cerevisiae (P53104), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Coglievina, M.; Klima, R.; Bertani, I.; Delneri, D.; Zaccaria, P.; Bruschi, C.V.
Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae
Yeast
13
55-64
1997
Saccharomyces cerevisiae (P53104)
Manually annotated by BRENDA team
Boyer, J.; Michaux, G.; Fairhead, C.; Gaillon, L.; Dujon, B.
Sequence and analysis of a 26.9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae
Yeast
12
1575-1586
1996
Saccharomyces cerevisiae (Q01919)
Manually annotated by BRENDA team
Kambouris, N.G.; Burke, D.J.; Creutz, C.E.
Cloning and genetic analysis of the gene encoding a new protein kinase in Saccharomyces cerevisiae
Yeast
9
141-150
1993
Saccharomyces cerevisiae (Q01919)
Manually annotated by BRENDA team
Longtine, M.S.; Fares, H.; Pringle, J.R.
Role of the yeast Gin4p protein kinase in septin assembly and the relationship between septin assembly and septin function
J. Cell Biol.
143
719-736
1998
Saccharomyces cerevisiae (Q12263), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Iraqui, I.; Vissers, S.; Cartiaux, M.; Urrestarazu, A.
Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily
Mol. Gen. Genet.
257
238-248
1998
Saccharomyces cerevisiae (P23291), Saccharomyces cerevisiae (P23292)
Manually annotated by BRENDA team
Robinson, L.C.; Hubbard, E.J.; Graves, P.R.; DePaoli-Roach, A.A.; Roach, P.J.; Kung, C.; Haas, D.W.; Hagedorn, C.H.; Goebl, M.; Culbertson, M.R.; et al.
Yeast casein kinase I homologues: an essential gene pair
Proc. Natl. Acad. Sci. USA
89
28-32
1992
Saccharomyces cerevisiae (P23291), Saccharomyces cerevisiae (P23292), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wang, P.C.; Vancura, A.; Mitcheson, T.G.; Kuret, J.
Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1
Mol. Biol. Cell
3
275-286
1992
Saccharomyces cerevisiae (P23291), Saccharomyces cerevisiae (P23292)
Manually annotated by BRENDA team
Nasr, F.; Becam, A.M.; Herbert, C.J.
The sequence of 36.8 kb from the left arm of chromosome XIV reveals 24 complete open reading frames: 18 correspond to new genes, one of which encodes a protein similar to the human myotonic dystrophy kinase
Yeast
12
169-175
1996
Saccharomyces cerevisiae (P23292), Saccharomyces cerevisiae (P53894)
Manually annotated by BRENDA team
Bussey, H.; Storms, R.K.; Ahmed, A.; Albermann, K.; et al.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI
Nature
387
103-105
1997
Saccharomyces cerevisiae (P29295), Saccharomyces cerevisiae (Q12505)
Manually annotated by BRENDA team
DeMaggio, A.J.; Lindberg, R.A.; Hunter, T.; Hoekstra, M.F.
The budding yeast HRR25 gene product is a casein kinase I isoform
Proc. Natl. Acad. Sci. USA
89
7008-7012
1992
Saccharomyces cerevisiae (P29295), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hoekstra, M.F.; Liskay, R.M.; Ou, A.C.; DeMaggio, A.J.; Burbee, D.G.; Heffron, F.
HRR25, a putative protein kinase from budding yeast: association with repair of damaged DNA
Science
253
1031-1034
1991
Saccharomyces cerevisiae (P29295), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wang, X.; Hoekstra, M.F.; DeMaggio, A.J.; Dhillon, N.; Vancura, A.; Kuret, J.; Johnston, G.C.; Singer, R.A.
Prenylated isoforms of yeast casein kinase I, including the novel Yck3p, suppress the gcs1 blockage of cell proliferation from stationary phase
Mol. Cell. Biol.
16
5375-5385
1996
Saccharomyces cerevisiae (P39962), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Amatruda, J.F.; Cooper, J.A.
Purification, characterization, and immunofluorescence localization of Saccharomyces cerevisiae capping protein
J. Cell Biol.
117
1067-1076
1992
Saccharomyces cerevisiae (P15790)
Manually annotated by BRENDA team
Chen-Wu, J.L.; Padmanabha, R.; Glover, C.V.
Isolation, sequencing, and disruption of the CKA1 gene encoding the alpha subunit of yeast casein kinase II
Mol. Cell. Biol.
8
4981-4990
1988
Saccharomyces cerevisiae (P15790), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Padmanabha, R.; Glover, C.V.
Casein kinase II of yeast contains two distinct alpha polypeptides and an unusually large beta subunit
J. Biol. Chem.
262
1829-1835
1987
Drosophila melanogaster (P08181), Saccharomyces cerevisiae (P15790), Saccharomyces cerevisiae (P19454), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Padmanabha, R.; Chen-Wu, J.L.; Hanna, D.E.; Glover, C.V.
Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae
Mol. Cell. Biol.
10
4089-4099
1990
Saccharomyces cerevisiae (P19454), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Valens, M.; Bohn, C.; Daignan-Fornier, B.; Dang, V.D.; Bolotin-Fukuhara, M.
The sequence of a 54.7 kb fragment of yeast chromosome XV reveals the presence of two tRNAs and 24 new open reading frames
Yeast
13
379-390
1997
Saccharomyces cerevisiae (P19454)
Manually annotated by BRENDA team
Maurer, K.C.; Urbanus, J.H.; Planta, R.J.
Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV carrying a ribosomal protein gene cluster, the genes encoding a plasma membrane protein and a subunit of replication factor C, and a novel putative serine/threonine protein kinase gene
Yeast
11
1303-1310
1995
Saccharomyces cerevisiae (P48562), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Percival-Smith, A.; Segall, J.
Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae
Mol. Cell. Biol.
6
2443-2451
1986
Saccharomyces cerevisiae (P08458)
Manually annotated by BRENDA team
Clark, M.W.; Keng, T.; Storms, R.K.; Zhong, W.; Fortin, N.; Zeng, B.; Delaney, S.; Ouellette, B.F.; Barton, A.B.; Kaback, D.B.; et al.
Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region
Yeast
10
535-541
1994
Saccharomyces cerevisiae (P22209), Saccharomyces cerevisiae (P27636)
Manually annotated by BRENDA team
Schweitzer, B.; Philippsen, P.
NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA
Mol. Gen. Genet.
234
164-167
1992
Saccharomyces cerevisiae (P22209), Saccharomyces cerevisiae (P27636)
Manually annotated by BRENDA team
Schweitzer, B.; Philippsen, P.
CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain
Yeast
7
265-273
1991
Saccharomyces cerevisiae (P27636)
Manually annotated by BRENDA team
Cvrckova, F.; De Virgilio, C.; Manser, E.; Pringle, J.R.; Nasmyth, K.
Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast
Genes Dev.
9
1817-1830
1995
Saccharomyces cerevisiae (P48562)
Manually annotated by BRENDA team
Leberer, E.; Dignard, D.; Harcus, D.; Thomas, D.Y.; Whiteway, M.
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components
EMBO J.
11
4815-4824
1992
Saccharomyces cerevisiae (Q03497)
Manually annotated by BRENDA team
Ramer, S.W.; Davis, R.W.
A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
90
452-456
1993
Saccharomyces cerevisiae (Q03497), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Martin, H.; Mendoza, A.; Rodriguez-Pachon, J.M.; Molina, M.; Nombela, C.
Characterization of SKM1, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK-like protein kinase
Mol. Microbiol.
23
431-444
1997
Saccharomyces cerevisiae (Q12469)
Manually annotated by BRENDA team
Vandenbol, M.; Durand, P.; Portetelle, D.; Hilger, F.
Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including the Tyl-H3 retrotransposon, the suf1(+) frameshift suppressor gene for tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element
Yeast
11
1069-1075
1995
Saccharomyces cerevisiae (Q12469), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Murakami, Y.; Naitou, M.; Hagiwara, H.; Shibata, T.; Ozawa, M.; Sasanuma, S.; Sasanuma, M.; Tsuchiya, Y.; Soeda, E.; Yokoyama, K.; et al.
Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae
Nat. Genet.
10
261-268
1995
Saccharomyces cerevisiae (P43565)
Manually annotated by BRENDA team
Vidan, S.; Mitchell, A.P.
Stimulation of yeast meiotic gene expression by the glucose-repressible protein kinase Rim15p
Mol. Cell. Biol.
17
2688-2697
1997
Saccharomyces cerevisiae (P43565), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Du, L.L.; Novick, P.
Pag1p, a novel protein associated with protein kinase Cbk1p, is required for cell morphogenesis and proliferation in Saccharomyces cerevisiae
Mol. Biol. Cell
13
503-514
2002
Saccharomyces cerevisiae (P53894), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Vandenbol, M.; Jauniaux, J.C.; Grenson, M.
The Saccharomyces cerevisiae NPR1 gene required for the activity of ammonia-sensitive amino acid permeases encodes a protein kinase homologue
Mol. Gen. Genet.
222
393-399
1990
Saccharomyces cerevisiae (P22211)
Manually annotated by BRENDA team
Biteau, N.; Fremaux, C.; Hebrard, S.; Menara, A.; Aigle, M.; Crouzet, M.
The complete sequence of a 10.8kb fragment to the right of the chromosome III centromere of Saccharomyces cerevisiae
Yeast
8
61-70
1992
Saccharomyces cerevisiae (P25333)
Manually annotated by BRENDA team
Skala, J.; Purnelle, B.; Crouzet, M.; Aigle, M.; Goffeau, A.
The open reading frame YCR101 located on chromosome III from Saccharomyces cerevisiae is a putative protein kinase
Yeast
7
651-655
1991
Saccharomyces cerevisiae (P25333)
Manually annotated by BRENDA team
Kakinuma, Y.; Maruyama, T.; Nozaki, T.; Wada, Y.; Ohsumi, Y.; Igarashi, K.
Cloning of the gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
216
985-992
1995
Saccharomyces cerevisiae (P36002), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kaouass, M.; Audette, M.; Ramotar, D.; Verma, S.; De Montigny, D.; Gamache, I.; Torossian, K.; Poulin, R.
The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae
Mol. Cell. Biol.
17
2994-3004
1997
Saccharomyces cerevisiae (P36002), Saccharomyces cerevisiae (P47116), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Fleischmann, M.; Stagljar, I.; Aebi, M.
Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase
Mol. Gen. Genet.
250
614-625
1996
Saccharomyces cerevisiae (P38691), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Huang, M.E.; Manus, V.; Chuat, J.C.; Galibert, F.
Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI
Yeast
12
869-875
1996
Saccharomyces cerevisiae (P47116), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Nozaki, T.; Nishimura, K.; Michael, A.J.; Maruyama, T.; Kakinuma, Y.; Igarashi, K.
A second gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
228
452-458
1996
Saccharomyces cerevisiae (P47116), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Yang, Z.; Bisson, L.F.
The SKS1 protein kinase is a multicopy suppressor of the snf3 mutation of Saccharomyces cerevisiae
Yeast
12
1407-1419
1996
Saccharomyces cerevisiae (Q12505), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Arroyo, J.; Garcia-Gonzalez, M.; Garcia-Saez, M.I.; Sanchez, M.; Nombela, C.
DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII
Yeast
13
357-363
1997
Saccharomyces cerevisiae (P41695), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Roberts, B.T.; Farr, K.A.; Hoyt, M.A.
The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase
Mol. Cell. Biol.
14
8282-8291
1994
Saccharomyces cerevisiae (P41695)
Manually annotated by BRENDA team
Bahman, M.; Buck, V.; White, A.; Rosamond, J.
Characterisation of the CDC7 gene product of Saccharomyces cerevisiae as a protein kinase needed for the initiation of mitotic DNA synthesis
Biochim. Biophys. Acta
951
335-343
1988
Saccharomyces cerevisiae (P06243)
Manually annotated by BRENDA team
Buck, V.; White, A.; Rosamond, J.
CDC7 protein kinase activity is required for mitosis and meiosis in Saccharomyces cerevisiae
Mol. Gen. Genet.
227
452-457
1991
Saccharomyces cerevisiae (P06243)
Manually annotated by BRENDA team
Ham, J.; Moore, D.; Rosamond, J.; Johnston, I.R.
Transcriptional analysis of the CDC7 protein kinase gene of Saccharomyces cerevisiae
Nucleic Acids Res.
17
5781-5792
1989
Saccharomyces cerevisiae (P06243)
Manually annotated by BRENDA team
Patterson, M.; Sclafani, R.A.; Fangman, W.L.; Rosamond, J.
Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae
Mol. Cell. Biol.
6
1590-1598
1986
Saccharomyces cerevisiae (P06243)
Manually annotated by BRENDA team
Facchin, S.; Lopreiato, R.; Stocchetto, S.; Arrigoni, G.; Cesaro, L.; Marin, O.; Carignani, G.; Pinna, L.A.
Structure-function analysis of yeast piD261/Bud32, an atypical protein kinase essential for normal cell life
Biochem. J.
364
457-463
2002
Saccharomyces cerevisiae (P53323), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ni, L.; Snyder, M.
A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae
Mol. Biol. Cell
12
2147-2170
2001
Saccharomyces cerevisiae (P53323)
Manually annotated by BRENDA team
Clemente, M.L.; Sartori, G.; Cardazzo, B.; Carignani, G.
Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes
Yeast
13
287-290
1997
Saccharomyces cerevisiae (P53323), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Shamu, C.E.; Walter, P.
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
EMBO J.
15
3028-3039
1996
Saccharomyces cerevisiae (P32361)
Manually annotated by BRENDA team
Mori, K.; Ma, W.; Gething, M.J.; Sambrook, J.
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus
Cell
74
743-756
1993
Saccharomyces cerevisiae (P32361), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Nikawa, J.; Yamashita, S.
IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae
Mol. Microbiol.
6
1441-1446
1992
Saccharomyces cerevisiae (P32361)
Manually annotated by BRENDA team
Barton, A.B.; Davies, C.J.; Hutchison, C.A.; Kaback, D.B.
Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases
Gene
117
137-140
1992
Saccharomyces cerevisiae (P22209)
Manually annotated by BRENDA team
Jones, D.G.; Rosamond, J.
Isolation of a novel protein kinase-encoding gene from yeast by oligodeoxyribonucleotide probing
Gene
90
87-92
1990
Saccharomyces cerevisiae (P22209)
Manually annotated by BRENDA team
Nakashima, M.; Takai, Y.; Yamamura, H.; Nishizuka, Y.
Protamine kinase from yeast
Biochim. Biophys. Acta
397
117-123
1975
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Coito, C.; Diamond, D.L.; Neddermann, P.; Korth, M.J.; Katze, M.G.
High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein
J. Virol.
78
3502-3513
2004
Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Bazzi, M.; Mantiero, D.; Trovesi, C.; Lucchini, G.; Longhese, M.P.
Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication
Mol. Cell. Biol.
30
131-145
2010
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Manandhar, S.; Ricarte, F.; Cocca, S.; Gharakhanian, E.
Saccharomyces cerevisiae Env7 is a novel serine/threonine kinase 16-related protein kinase and negatively regulates organelle fusion at the lysosomal vacuole
Mol. Cell. Biol.
33
526-542
2013
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Manually annotated by BRENDA team
Bedard, L.; Dronamraju, R.; Kerschner, J.; Hunter, G.; Axley, E.; Boyd, A.; Strahl, B.; Mosley, A.
Quantitative analysis of dynamic protein interactions during transcription reveals a role for casein kinase II in Polymerase-associated Factor (PAF) complex phosphorylation and regulation of histone H2B monoubiquitylation
J. Biol. Chem.
291
13410-13420
2016
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hsieh, L.; Su, W.; Han, G.; Carman, G.
Phosphorylation of yeast Pah1 phosphatidate phosphatase by casein kinase II regulates its function in lipid metabolism
J. Biol. Chem.
291
9974-9990
2016
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Stalder, D.; Novick, P.
The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p
Mol. Biol. Cell
27
686-701
2016
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Glowczewski Bedard, L.; Dronamraju, R.; Kerschner, J.L.; Hunter, G.O.; DeVlieger Axley, E.; Boyd, A.K.; Strahl, B.D.; Mosley, A.L.
Quantitative analysis of dynamic protein interactions during transcription reveals a role for casein kinase II in polymerase-associated factor (PAF) complex phosphorylation and regulation of histone H2B monoubiquitylation
J. Biol. Chem.
291
13410-13420
2016
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hsieh, L.; Su, W.; Han, G.; Carman, G.
Phosphorylation of yeast Pah1 phosphatidate phosphatase by casein kinase II regulates its function in lipid metabolism
J. Biol. Chem.
291
9974-9990
2016
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Stalder, D.; Novick, P.
The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p
Mol. Biol. Cell
27
686-701
2016
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
-
Manually annotated by BRENDA team
Hassaninasab, A.; Hsieh, L.; Su, W.; Han, G.; Carman, G.
Yck1 casein kinase I regulates the activity and phosphorylation of Pah1 phosphatidate phosphatase from Saccharomyces cerevisiae
J. Biol. Chem.
294
18256-18268
2019
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741-YCK1-TAP
Manually annotated by BRENDA team