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17alpha-hydroxyprogesterone deacetylase deficiency
Early steps in androgen biosynthesis: from cholesterol to DHEA.
Aberrant Crypt Foci
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.
Aberrant Crypt Foci
Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers.
Aberrant Crypt Foci
Plum polyphenols inhibit colorectal aberrant crypt foci formation in rats: potential role of the miR-143/protein kinase B/mammalian target of rapamycin axis.
Abortion, Habitual
TAAR1 induces a disturbed GSK3? phosphorylation in recurrent miscarriages through the ODC.
Abortion, Spontaneous
Fibroblast Growth Factor 7 Regulates Proliferation and Decidualization of Human Endometrial Stromal Cells via ERK and JNK Pathway in an Autocrine Manner.
Abscess
A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient.
Acantholysis
In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades.
Acidosis
Acidosis alters the phosphorylation of Ser16 and Thr17 of phospholamban in rat cardiac muscle.
Acidosis
Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia.
Acidosis
Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation.
Acidosis
Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis.
Acidosis
CaMKII? Met281/282 oxidation is not required for recovery of calcium transients during acidosis.
Acidosis
Compensatory role of CaMKII on ICa and SR function during acidosis in rat ventricular myocytes.
Acidosis
Dietary salt modulates the sodium chloride cotransporter expression likely through an aldosterone-mediated WNK4-ERK1/2 signaling pathway.
Acidosis
Effects of NH4Cl intake on renal growth in rats: role of MAPK signalling pathway.
Acidosis
Effects on recovery during acidosis in cardiac myocytes overexpressing CaMKII.
Acidosis
GPR68 Contributes to Persistent Acidosis-Induced Activation of AGC Kinases and Tyrosine Phosphorylation in Organotypic Hippocampal Slices.
Acidosis
Hypercapnia Accelerates Adipogenesis: A Novel Role of High CO2 in Exacerbating Obesity.
Acidosis
Hypercapnic acidosis confers antioxidant and anti-apoptosis effects against ventilator-induced lung injury.
Acidosis
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Acidosis
Intracellular acidosis via activation of Akt-Girdin signaling promotes post ischemic angiogenesis during hyperglycemia.
Acidosis
Mechanisms involved in the acidosis enhancement of the isoproterenol-induced phosphorylation of phospholamban in the intact heart.
Acidosis
Molecular mechanisms of insulin resistance in chronic kidney disease.
Acidosis
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.
Acidosis
Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes.
Acidosis
Phospholamban phosphorylation by CaMKII under pathophysiological conditions.
Acidosis
Ras triggers acidosis-induced activation of the extracellular-signal-regulated kinase pathway in cardiac myocytes.
Acidosis
Role of CaMKII in post acidosis arrhythmias: a simulation study using a human myocyte model.
Acidosis
The paradigm of postconditioning to protect the heart.
Acidosis, Lactic
Detection of 14-3-3 protein in the cerebrospinal fluid in mitochondrial encephalopathy with lactic acidosis and stroke-like episodes.
Acidosis, Lactic
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
Acquired Immunodeficiency Syndrome
Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease.
Acquired Immunodeficiency Syndrome
Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis.
Acquired Immunodeficiency Syndrome
Diagnosis of Creutzfeldt-Jakob disease: effect of clinical criteria on incidence estimates. Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease.
Acquired Immunodeficiency Syndrome
Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis.
Acquired Immunodeficiency Syndrome
In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.
Acquired Immunodeficiency Syndrome
Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction.
Acquired Immunodeficiency Syndrome
Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination.
Acquired Immunodeficiency Syndrome
Neuroprotective strategies for HIV-1 associated dementia.
Acquired Immunodeficiency Syndrome
Regulation of ROCK1 via Notch1 during breast cancer cell migration into dense matrices.
Acquired Immunodeficiency Syndrome
The fine-structural distribution of G-protein receptor kinase 3, beta-arrestin-2, Ca2+/calmodulin-dependent protein kinase II and phosphodiesterase PDE1C2, and a Cl(-)-cotransporter in rodent olfactory epithelia.
Acquired Immunodeficiency Syndrome
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Acromegaly
MEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics.
Acromegaly
Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.
Acromegaly
Treatment of acromegaly in the era of personalized and predictive medicine.
Acute Kidney Injury
Activity of the Ste20-like Kinase, SLK, is Enhanced by Homodimerization.
Acute Kidney Injury
Effect of ATM on inflammatory response and autophagy in renal tubular epithelial cells in LPS-induced septic AKI.
Acute Kidney Injury
Effects of chronic alcohol exposure on ischemia-reperfusion-induced acute kidney injury in mice: the role of ?-arrestin 2 and glycogen synthase kinase 3.
Acute Kidney Injury
Glutamine attenuates tubular cell apoptosis in acute kidney injury via inhibition of the c-Jun N-terminal kinase phosphorylation of 14-3-3*
Acute Kidney Injury
Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice.
Acute Kidney Injury
Glycogen Synthase Kinase-3 Signaling in Acute Kidney Injury.
Acute Kidney Injury
GSK3beta plays dirty in acute kidney injury.
Acute Kidney Injury
Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.
Acute Kidney Injury
Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis.
Acute Kidney Injury
Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
Acute Kidney Injury
Meprin ? Activity Modulates the beta Catalytic Subunit of Protein Kinase A (PKA C?) in Ischemia/Reperfusion-Induced Acute Kidney Injury.
Acute Kidney Injury
Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.
Acute Kidney Injury
Regulation of the Ste20-like Kinase, SLK: INVOLVEMENT OF ACTIVATION SEGMENT PHOSPHORYLATION.
Acute Kidney Injury
ROCK1 regulates sepsis-induced acute kidney injury via TLR2-mediated endoplasmic reticulum stress/pyroptosis axis.
Acute Kidney Injury
The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease.
Acute Lung Injury
Acid-Induced Acute Lung Injury in Mice Associates with p44/42 and c-Jun N-Terminal Kinase Activation and Requires the Function of Tumor Necrosis Factor-? Receptor I.
Acute Lung Injury
Activation of protein kinase A is required for hydroxysafflor yellow A-mediated protection against oleic acid-induced acute lung injury.
Acute Lung Injury
Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-?B signaling pathway.
Acute Lung Injury
Deletion of peroxiredoxin 6 is protective in lipopolysaccharide-induced acute lung injury in mice*
Acute Lung Injury
Glycogen synthase kinase-3 beta inhibitors protectagainst the acute lung injuries resulting from acute necrotizing pancreatitis.
Acute Lung Injury
GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury.
Acute Lung Injury
MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1.
Acute Lung Injury
Protective role of JNK inhibitor SP600125 in sepsis-induced acute lung injury.
Acute Lung Injury
ROCK1 regulates sepsis-induced acute kidney injury via TLR2-mediated endoplasmic reticulum stress/pyroptosis axis.
Acute Lung Injury
Tanshinone IIA suppresses lung injury and apoptosis, and modulates protein kinase B and extracellular signal-regulated protein kinase pathways in rats challenged with seawater exposure.
Acute Radiation Syndrome
Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain- Dependent Manner in Mice.
Acute Radiation Syndrome
Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in Mice.
Adenocarcinoma
(-)-Epigallocatechin 3-gallate inhibits invasion by inducing the expression of Raf kinase inhibitor protein in AsPC?1 human pancreatic adenocarcinoma cells through the modulation of histone deacetylase activity.
Adenocarcinoma
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Adenocarcinoma
A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.
Adenocarcinoma
A Pyloric Gland-Phenotype Ovarian Mucinous Tumor Resembling Lobular Endocervical Glandular Hyperplasia in a Patient with Peutz-Jeghers Syndrome.
Adenocarcinoma
Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.
Adenocarcinoma
Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens.
Adenocarcinoma
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Adenocarcinoma
Activation of Raf-1 in human pancreatic adenocarcinoma.
Adenocarcinoma
Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia.
Adenocarcinoma
An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice.
Adenocarcinoma
APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.
Adenocarcinoma
Association of cellular localization of glycogen synthase kinase 3beta in the digestive tract with cancer development.
Adenocarcinoma
Aurora kinase inhibitors as anti-cancer therapy.
Adenocarcinoma
Autophagy Regulatory Genes MET and RIPK2 Play a Prognostic Role in Pancreatic Ductal Adenocarcinoma: A Bioinformatic Analysis Based on GEO and TCGA.
Adenocarcinoma
BUB1 promotes proliferation of liver cancer cells by activating SMAD2 phosphorylation.
Adenocarcinoma
Citron Rho-Interacting Serine/Threonine Kinase Promotes HIF1a-CypA Signaling and Growth of Human Pancreatic Adenocarcinoma.
Adenocarcinoma
Clinicopathologic Characteristics of BRG1-Deficient NSCLC.
Adenocarcinoma
Clinicopathological and Molecular Study of Peritoneal Carcinomatosis Associated with Non-Small Cell Lung Carcinoma.
Adenocarcinoma
Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA).
Adenocarcinoma
Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.
Adenocarcinoma
Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9.
Adenocarcinoma
Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis.
Adenocarcinoma
Coordinately Targeting Cell-Cycle Checkpoint Functions in Integrated Models of Pancreatic Cancer.
Adenocarcinoma
Correlation among RKIP expression, NF-?B p65 levels, and T-lymphocyte subsets in gastric cardia adenocarcinoma.
Adenocarcinoma
CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer.
Adenocarcinoma
Curcumin Rescues Doxorubicin Responsiveness via Regulating Aurora a Signaling Network in Breast Cancer Cells.
Adenocarcinoma
Cytokeratin 8 and 19 as antigens recognized by adenocarcinoma-reactive human monoclonal antibody AE6F4.
Adenocarcinoma
Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models.
Adenocarcinoma
DNA-PKcs and Ku70 are predictive markers for poor prognosis of patients with gall bladder malignancies.
Adenocarcinoma
Edible oil adulterants, argemone oil and butter yellow, as aetiological factors for gall bladder cancer.
Adenocarcinoma
Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.
Adenocarcinoma
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
Adenocarcinoma
Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy.
Adenocarcinoma
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Adenocarcinoma
Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
Adenocarcinoma
Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma.
Adenocarcinoma
Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways.
Adenocarcinoma
Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo.
Adenocarcinoma
Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis.
Adenocarcinoma
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Adenocarcinoma
Gene of the month: STK11.
Adenocarcinoma
Genetic Aberration Analysis in Thai Colorectal Adenoma and Early-Stage Adenocarcinoma Patients by Whole-Exome Sequencing.
Adenocarcinoma
Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome.
Adenocarcinoma
Glycogen Synthase Kinase 3 Beta Predicts Survival in Resected Adenocarcinoma of the Pancreas.
Adenocarcinoma
GSK-3 inhibitors enhance TRAIL-mediated apoptosis in human gastric adenocarcinoma cells.
Adenocarcinoma
GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma.
Adenocarcinoma
High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder.
Adenocarcinoma
Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants.
Adenocarcinoma
HT 29, a model cell line: stimulation by the vasoactive intestinal peptide (VIP); VIP receptor structure and metabolism.
Adenocarcinoma
Immunohistochemical analysis of Ki-67, PCNA and S6K1/2 expression in human breast cancer.
Adenocarcinoma
Immunohistochemical analysis of S6K1 and S6K2 expression in endometrial adenocarcinomas.
Adenocarcinoma
Immunohistochemical characterization of the mTOR pathway in stage-I non-small-cell lung carcinoma.
Adenocarcinoma
Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis.
Adenocarcinoma
Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma.
Adenocarcinoma
Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells.
Adenocarcinoma
Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells.
Adenocarcinoma
Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.
Adenocarcinoma
Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression.
Adenocarcinoma
Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome.
Adenocarcinoma
Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A.
Adenocarcinoma
LncRNA LINK-A regulates ROCK1 expression in early-stage pancreatic adenocarcinoma.
Adenocarcinoma
lncRNA-CCHE1 is involved in migration and invasion but not in proliferation of pancreatic adenocarcinoma cells possibly by interacting with ROCK1.
Adenocarcinoma
Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC).
Adenocarcinoma
Loss of Raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma.
Adenocarcinoma
Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms.
Adenocarcinoma
Low expression of A-kinase anchor protein 5 predicts poor prognosis in non-mucin producing stomach adenocarcinoma based on TCGA data.
Adenocarcinoma
Malignant tumors associated with Peutz-Jeghers syndrome: Five cases from a single surgical unit.
Adenocarcinoma
Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations.
Adenocarcinoma
Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase ?1 expression.
Adenocarcinoma
Methylation of CALCA and CALCB in Pancreatic Ductal Adenocarcinoma.
Adenocarcinoma
Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma.
Adenocarcinoma
Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells.
Adenocarcinoma
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Adenocarcinoma
Modified protein kinase activity and isozyme distribution in adenocarcinoma of the human colon.
Adenocarcinoma
Molecular and pathological basis of HPV-negative cervical adenocarcinoma seen in a global study.
Adenocarcinoma
Molecular pathology of lung cancer: current status and perspectives.
Adenocarcinoma
Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement.
Adenocarcinoma
Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.
Adenocarcinoma
Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11.
Adenocarcinoma
Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas.
Adenocarcinoma
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
Adenocarcinoma
Na+/H+ exchanger regulatory factor 1 overexpression suppresses the malignant phenotype of MIAPaCa-2 pancreatic adenocarcinoma cells by downregulating Akt phosphorylation.
Adenocarcinoma
NEAT1/miR-101-dependent Up-regulation of DNA-PKcs Enhances Malignant Behaviors of Pancreatic Ductal Adenocarcinoma Cells.
Adenocarcinoma
Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers.
Adenocarcinoma
Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1.
Adenocarcinoma
Next-Generation Sequencing Approach to Non-Small Cell Lung Carcinoma Yields More Actionable Alterations.
Adenocarcinoma
Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma.
Adenocarcinoma
Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma.
Adenocarcinoma
Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.
Adenocarcinoma
PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations.
Adenocarcinoma
Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice.
Adenocarcinoma
Phosph-Akt1 expression is associated with a favourable prognosis in pancreatic cancer.
Adenocarcinoma
Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer.
Adenocarcinoma
Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.
Adenocarcinoma
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Adenocarcinoma
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
Adenocarcinoma
Prognostic value of p21-activated kinase 4 in resected pancreatic cancer.
Adenocarcinoma
Promoter methylation of Raf kinase inhibitory protein: A significant prognostic indicator for patients with gastric adenocarcinoma.
Adenocarcinoma
Protein kinase B phosphorylation correlates with vascular endothelial growth factor a and microvessel density in gastric adenocarcinoma.
Adenocarcinoma
Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.
Adenocarcinoma
REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer.
Adenocarcinoma
Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers.
Adenocarcinoma
Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression.
Adenocarcinoma
ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells.
Adenocarcinoma
Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer.
Adenocarcinoma
Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours.
Adenocarcinoma
STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1?.
Adenocarcinoma
Susceptibility of ATM-deficient pancreatic cancer cells to radiation.
Adenocarcinoma
Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
Adenocarcinoma
Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library.
Adenocarcinoma
The effect of menadione on glutathione S-transferase A1 (GSTA1): c-Jun N-terminal kinase (JNK) complex dissociation in human colonic adenocarcinoma Caco-2 cells.
Adenocarcinoma
The PRKD1 promoter is a target of the KRas-NF-?B pathway in pancreatic cancer.
Adenocarcinoma
The usefulness of S100P, mesothelin, fascin, prostate stem cell antigen, and 14-3-3 sigma in diagnosing pancreatic adenocarcinoma in cytological specimens obtained by endoscopic ultrasound guided fine-needle aspiration.
Adenocarcinoma
Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line.
Adenocarcinoma
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines.
Adenocarcinoma
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines.]
Adenocarcinoma
[Determination of cyclic AMP and protein kinases in the diagnosis of colonic tumors]
Adenocarcinoma
[Expression of PKB protein in human squamous-cell carcinoma and adenocarcinoma of lung]
Adenocarcinoma of Lung
37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade.
Adenocarcinoma of Lung
A combination of tumor and molecular markers predicts a poor prognosis in lung adenocarcinoma.
Adenocarcinoma of Lung
A phase II study of everolimus in patients with advanced solid malignancies with TSC1, TSC2, NF1, NF2 or STK11 mutations.
Adenocarcinoma of Lung
A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Aberrant Stratifin Overexpression Is Regulated by Tumor-Associated CpG Demethylation in Lung Adenocarcinoma.
Adenocarcinoma of Lung
AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.
Adenocarcinoma of Lung
Akt/mTOR mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells.
Adenocarcinoma of Lung
Analyses of the oncogenic BRAFD594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling.
Adenocarcinoma of Lung
Association of serine/threonine kinase 11 mutations and response to programmed cell death 1 inhibitors in metastatic gastric cancer.
Adenocarcinoma of Lung
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
Adenocarcinoma of Lung
Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome.
Adenocarcinoma of Lung
Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway.
Adenocarcinoma of Lung
Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells.
Adenocarcinoma of Lung
Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9.
Adenocarcinoma of Lung
Comparative proteome analysis of human adenocarcinoma.
Adenocarcinoma of Lung
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.
Adenocarcinoma of Lung
Correction: STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort.
Adenocarcinoma of Lung
Correlation between STK33 and the pathology and prognosis of lung cancer.
Adenocarcinoma of Lung
Curcumol inhibits lung adenocarcinoma growth and metastasis via inactivation of PI3K/AKT and Wnt/ß-catenin pathway.
Adenocarcinoma of Lung
Cyclic AMP-responsive expression of the surfactant protein-A gene is mediated by increased DNA binding and transcriptional activity of thyroid transcription factor-1.
Adenocarcinoma of Lung
Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma.
Adenocarcinoma of Lung
Distinct biological effects of low-dose radiation on normal and cancerous human lung cells are mediated by ATM signaling.
Adenocarcinoma of Lung
DNA-dependent protein kinase catalytic subunit inhibitor reverses acquired radioresistance in lung adenocarcinoma by suppressing DNA repair.
Adenocarcinoma of Lung
Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis.
Adenocarcinoma of Lung
Effect of 14-3-3 protein induction on cell proliferation of A549 human lung adenocarcinoma.
Adenocarcinoma of Lung
Estrogen related receptor-alpha enhances surfactant protein-A gene expression in fetal lung type II cells.
Adenocarcinoma of Lung
Expression and clinical significance of A-kinase anchor protein 4 in lung adenocarcinoma tissue.
Adenocarcinoma of Lung
Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma.
Adenocarcinoma of Lung
Expression of AKT and p-AKT protein in lung adenocarcinoma and its correlation with PD-L1 protein and prognosis.
Adenocarcinoma of Lung
Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients.
Adenocarcinoma of Lung
Glycogen synthase kinase 3beta induces cell cycle arrest in a cyclin D1-dependent manner in human lung adenocarcinoma cell line A549.
Adenocarcinoma of Lung
Identification of unique heterozygous germline mutation, STK11 (p.F354L), in a child with encapsulated follicular variant of papillary thyroid carcinoma within 6 months of completing treatment for neuroblastoma.
Adenocarcinoma of Lung
Incidence of Lung Adenocarcinoma Biomarker in a Caribbean and African Caribbean Population.
Adenocarcinoma of Lung
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Adenocarcinoma of Lung
Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3? and osteopontin.
Adenocarcinoma of Lung
Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells.
Adenocarcinoma of Lung
Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells.
Adenocarcinoma of Lung
Less immune cell infiltration and worse prognosis after immunotherapy for patients with lung adenocarcinoma who harbored STK11 mutation.
Adenocarcinoma of Lung
LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.
Adenocarcinoma of Lung
LKB1/STK11 Expression in Lung Adenocarcinoma and Associations With Patterns of Recurrence.
Adenocarcinoma of Lung
LncRNA MALAT1 regulates trophoblast cells migration and invasion via miR-206/IGF-1 axis.
Adenocarcinoma of Lung
Loss of cellular identity in common pre-clinical models of serine?threonine kinase 11 (Liver kinase B1) loss.
Adenocarcinoma of Lung
Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Adenocarcinoma of Lung
MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.
Adenocarcinoma of Lung
MicroRNA-197 induces epithelial-mesenchymal transition and invasion through the downregulation of HIPK2 in lung adenocarcinoma.
Adenocarcinoma of Lung
MiR-195-5p is a Potential Factor Responsible for CPNE1 Differential Expression between Subtypes of Non-Small Cell Lung Cancer.
Adenocarcinoma of Lung
Molecular alterations in non-small cell lung carcinomas of the young.
Adenocarcinoma of Lung
mRNA expression of programmed cell death ligand 1 and components of the phosphatidylinositol 3-kinase/AKT/phosphatase and tensin homolog pathway in epidermal growth factor receptor mutation-positive lung adenocarcinoma.
Adenocarcinoma of Lung
Multiparameter analysis using cell cycle biomarkers for small-size lung adenocarcinoma: prognostic implications.
Adenocarcinoma of Lung
Multiplex Diagnosis of Oncogenic Fusion and MET Exon Skipping by Molecular Counting Using Formalin-Fixed Paraffin Embedded Lung Adenocarcinoma Tissues.
Adenocarcinoma of Lung
Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma.
Adenocarcinoma of Lung
MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells.
Adenocarcinoma of Lung
NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes.
Adenocarcinoma of Lung
Overexpressed Raf-1 and phosphorylated cyclic adenosine 3'-5'-monophosphatate response element-binding protein are early markers for lung adenocarcinoma.
Adenocarcinoma of Lung
Overexpression of HOTTIP promotes proliferation and drug resistance of lung adenocarcinoma by regulating AKT signaling pathway.
Adenocarcinoma of Lung
Overexpression of T-LAK cell-originated protein kinase predicts poor prognosis in patients with stage I lung adenocarcinoma.
Adenocarcinoma of Lung
PEST-containing nuclear protein regulates cell proliferation, migration, and invasion in lung adenocarcinoma.
Adenocarcinoma of Lung
Relevance of STK11 Mutations Regarding Immune Cell Infiltration, Drug Sensitivity, and Cellular Processes in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4.
Adenocarcinoma of Lung
RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation.
Adenocarcinoma of Lung
Serum proteomics of lung adenocarcinomas induced by targeted overexpression of c-raf in alveolar epithelium identifies candidate biomarkers.
Adenocarcinoma of Lung
SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia.
Adenocarcinoma of Lung
Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.
Adenocarcinoma of Lung
Somatic STK11 and Concomitant STK11/KRAS Mutational Frequency in Stage IV Lung Adenocarcinoma Adrenal Metastases.
Adenocarcinoma of Lung
STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort.
Adenocarcinoma of Lung
STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.
Adenocarcinoma of Lung
STK33-dependent transcriptional regulation of SFTA3 induces Cisplatin-resistance in lung adenocarcinoma.
Adenocarcinoma of Lung
Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.
Adenocarcinoma of Lung
The effect of ataxia-telangiectasia mutated kinase-dependent hyperphosphorylation of checkpoint kinase-2 on oligodeoxynucleotide 7909 containing CpG motifs-enhanced sensitivity to X-rays in human lung adenocarcinoma A549 cells.
Adenocarcinoma of Lung
The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1.
Adenocarcinoma of Lung
TP53, STK11, and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti-PD-1 in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Undetectable circulating tumor DNA levels correlate with low risk of recurrence/metastasis in postoperative pathologic stage I lung adenocarcinoma patients.
Adenocarcinoma of Lung
Whole Exome Profiling of NSCLC Among African Americans.
Adenocarcinoma of Lung
[Comparison of DNA-dependent protein kinase catalytic subunit expression in two lung adenocarcinoma cell lines with different radiosensitivity]
Adenocarcinoma of Lung
[Expression of PKB protein in human squamous-cell carcinoma and adenocarcinoma of lung]
Adenocarcinoma of Lung
[The effects of Tumstatin185-191 on lung adenocarcinoma cell lines and the association with protein kinase B and extracellularregulated protein kinase activation.]
Adenocarcinoma, Bronchiolo-Alveolar
Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome.
Adenocarcinoma, Clear Cell
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
Adenocarcinoma, Follicular
ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status.
Adenocarcinoma, Follicular
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Adenocarcinoma, Follicular
PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma.
Adenocarcinoma, Mucinous
A tumor of the uterine cervix with a complex histology in a Peutz-Jeghers syndrome patient with genomic deletion of the STK11 exon 1 region.
Adenocarcinoma, Mucinous
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Adenocarcinoma, Mucinous
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
Adenocarcinoma, Mucinous
Peutz-Jeghers syndrome complicated by gastric-type cervical mucinous carcinoma and primary peritoneal carcinoma.
Adenocarcinoma, Mucinous
Pulmonary Invasive Mucinous Adenocarcinoma and Mixed Invasive Mucinous/Non-Mucinous Adenocarcinoma- A Clinicopathological and Molecular Genetic Study with Survival Analysis.
Adenocarcinoma, Mucinous
[Correlations between the p-Akt-mTOR-p70S6K pathway and clinicopathological features or chemoresistance of ovarian cancer].
Adenoma
14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.
Adenoma
18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway.
Adenoma
A case of Peutz-Jeghers syndrome with breast cancer, bilateral sex cord tumor with annular tubules, and adenoma malignum caused by STK11 gene mutation.
Adenoma
A genetic and molecular update on adrenocortical causes of Cushing syndrome.
Adenoma
A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
Adenoma
Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia.
Adenoma
Activating PRKACB somatic mutation in cortisol-producing adenomas.
Adenoma
Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia.
Adenoma
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
Adenoma
APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.
Adenoma
Calmodulin and calmodulin-dependent protein kinase II (CaMKII) inhibit hormone secretion in human parathyroid adenoma.
Adenoma
Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.
Adenoma
CpG island methylation in premalignant stages of gastric carcinoma.
Adenoma
Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas.
Adenoma
DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas.
Adenoma
Down-regulation of D2 dopamine receptor and increased protein kinase Cmu phosphorylation in aldosterone-producing adenoma play roles in aldosterone overproduction.
Adenoma
Edible oil adulterants, argemone oil and butter yellow, as aetiological factors for gall bladder cancer.
Adenoma
Expression of Glut-1, HIF-1?, PI3K and p-Akt in a case of ceruminous adenoma.
Adenoma
G-protein and signalling in pituitary tumours.
Adenoma
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Adenoma
Genetic Causes of Functional Adrenocortical Adenomas.
Adenoma
Genomics of benign adrenocortical tumors.
Adenoma
Increased protein kinase A type I? regulatory subunit expression in parathyroid gland adenomas of patients with primary hyperparathyroidism.
Adenoma
Lipopolysaccharides Enhance Epithelial Hyperplasia and Tubular Adenoma in Intestine-Specific Expression of krasV12 in Transgenic Zebrafish.
Adenoma
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Adenoma
Morphologic and Molecular Findings in Myxoid Hepatic Adenomas.
Adenoma
Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
Adenoma
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Adenoma
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Adenoma
PAK1 promotes intestinal tumor initiation.
Adenoma
Possible relevance between prohormone convertase 2 expression and tumor growth in human adrenocorticotropin-producing pituitary adenoma.
Adenoma
PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations.
Adenoma
PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.
Adenoma
Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
Adenoma
Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library.
Adenoma
The gsp Oncogene Disrupts Ras/ERK-Dependent Prolactin Gene Regulation in gsp Inducible Somatotroph Cell Line.
Adenoma
Treatment of acromegaly in the era of personalized and predictive medicine.
Adenoma
[Clinicopathological significance of expression and amplification of P21-activated kinase 1 gene in colorectal carcinoma]
Adenoma
[Construction of GSK-3beta-targeting RNAi adenovirus vector and the influence of Wnt/beta-catenin pathway in proliferation of human thyrocytes]
Adenoma
[Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma].
Adenoma
[Expression of DNA-PK in hepato- and cholangio-neoplasms and its significance.]
Adenoma
[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms]
Adenoma, Bile Duct
Cystic cholangiomas after transplantation of pancreatic islets into the livers of diabetic rats.
Adenoma, Liver Cell
Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma.
Adenoma, Oxyphilic
Akt signalling parameters are different in oncocytomas compared to renal cell carcinoma.
Adenoma, Pleomorphic
Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma.
Adenomatous Polyposis Coli
?-catenin at the centrosome: Discrete pools of ?-catenin communicate during mitosis and may co-ordinate centrosome functions and cell cycle progression.
Adenomatous Polyposis Coli
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.
Adenomatous Polyposis Coli
Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction.
Adenomatous Polyposis Coli
Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.
Adenomatous Polyposis Coli
Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway.
Adenomatous Polyposis Coli
Akt regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo.
Adenomatous Polyposis Coli
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.
Adenomatous Polyposis Coli
Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein.
Adenomatous Polyposis Coli
Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer.
Adenomatous Polyposis Coli
Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway.
Adenomatous Polyposis Coli
Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling.
Adenomatous Polyposis Coli
Axin prevents Wnt-3a-induced accumulation of beta-catenin.
Adenomatous Polyposis Coli
Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon.
Adenomatous Polyposis Coli
Beta-catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts.
Adenomatous Polyposis Coli
Beta-catenin is temporally regulated during normal liver development.
Adenomatous Polyposis Coli
Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.
Adenomatous Polyposis Coli
Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription.
Adenomatous Polyposis Coli
Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK.
Adenomatous Polyposis Coli
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity.
Adenomatous Polyposis Coli
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity.
Adenomatous Polyposis Coli
Colon Cancer: A Clinician's Perspective in 2019.
Adenomatous Polyposis Coli
Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.
Adenomatous Polyposis Coli
Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin.
Adenomatous Polyposis Coli
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
Adenomatous Polyposis Coli
Control of beta-catenin/Tcf-directed transcription in medulloblastoma.
Adenomatous Polyposis Coli
Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway.
Adenomatous Polyposis Coli
Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin.
Adenomatous Polyposis Coli
Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons.
Adenomatous Polyposis Coli
DNA hypermethylation profiles in squamous cell carcinoma of the vulva.
Adenomatous Polyposis Coli
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.
Adenomatous Polyposis Coli
Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice.
Adenomatous Polyposis Coli
Effects of rat Axin domains on axis formation in Xenopus embryos.
Adenomatous Polyposis Coli
Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells.
Adenomatous Polyposis Coli
Familial pancreatic carcinoma in Jews.
Adenomatous Polyposis Coli
Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma.
Adenomatous Polyposis Coli
Genetic testing by cancer site: stomach.
Adenomatous Polyposis Coli
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
Adenomatous Polyposis Coli
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation.
Adenomatous Polyposis Coli
Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/beta-catenin signal via ISGylation of beta-catenin.
Adenomatous Polyposis Coli
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.
Adenomatous Polyposis Coli
H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes.
Adenomatous Polyposis Coli
Hepatic adenomas: analysis of sex steroid receptor status and the Wnt signaling pathway.
Adenomatous Polyposis Coli
Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
Adenomatous Polyposis Coli
Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.
Adenomatous Polyposis Coli
Identification of a Wnt/beta-catenin signaling pathway in human thyroid cells.
Adenomatous Polyposis Coli
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
Adenomatous Polyposis Coli
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
Adenomatous Polyposis Coli
IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways.
Adenomatous Polyposis Coli
Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A.
Adenomatous Polyposis Coli
Inhibition of Wnt signaling pathway by a novel axin-binding protein.
Adenomatous Polyposis Coli
Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction.
Adenomatous Polyposis Coli
Intracholecystic Papillary Neoplasms Are Distinct From Papillary Gallbladder Cancers: A Clinicopathologic and Exome-sequencing Study.
Adenomatous Polyposis Coli
Involvement of CDX2 in the cross talk between TNF-? and Wnt signaling pathway in the colon cancer cell line Caco-2.
Adenomatous Polyposis Coli
Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.
Adenomatous Polyposis Coli
LKB1-mediated spatial control of GSK3beta and adenomatous polyposis coli contributes to centrosomal forward movement and neuronal migration in the developing neocortex.
Adenomatous Polyposis Coli
Localization of the adenomatous polyposis coli tumour suppressor protein in the mouse central nervous system.
Adenomatous Polyposis Coli
Long non-coding RNA miR143HG predicts good prognosis and inhibits tumor multiplication and metastasis by suppressing mitogen-activated protein kinase and Wnt signaling pathways in hepatocellular carcinoma.
Adenomatous Polyposis Coli
Long-fragment DNA as a potential marker for stool-based detection of colorectal cancer.
Adenomatous Polyposis Coli
LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.
Adenomatous Polyposis Coli
Manilkara zapota (L.) P. Royen leaf water extract triggered apoptosis and activated caspase-dependent pathway in HT-29 human colorectal cancer cell line.
Adenomatous Polyposis Coli
MicroRNA-218 competes with differentiation media in the induction of osteogenic differentiation of mesenchymal stem cell by regulating ?-catenin inhibitors.
Adenomatous Polyposis Coli
Modulation of Wnt signaling by Axin and Axil.
Adenomatous Polyposis Coli
Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells.
Adenomatous Polyposis Coli
Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.
Adenomatous Polyposis Coli
Molecular regulation and pharmacological targeting of the ?-catenin destruction complex.
Adenomatous Polyposis Coli
Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression.
Adenomatous Polyposis Coli
Nestin positively regulates the Wnt/?-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells.
Adenomatous Polyposis Coli
Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3{beta}) independently of Akt/PKB serine phosphorylation.
Adenomatous Polyposis Coli
Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation.
Adenomatous Polyposis Coli
Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells.
Adenomatous Polyposis Coli
Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1.
Adenomatous Polyposis Coli
Nuclear GSK-3? segregation in desmoid-type fibromatosis.
Adenomatous Polyposis Coli
Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion.
Adenomatous Polyposis Coli
Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis.
Adenomatous Polyposis Coli
Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway.
Adenomatous Polyposis Coli
Phase separation of Axin organizes the ?-catenin destruction complex.
Adenomatous Polyposis Coli
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
Adenomatous Polyposis Coli
Regulation of glycogen synthase kinase 3beta and downstream Wnt signaling by axin.
Adenomatous Polyposis Coli
Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization.
Adenomatous Polyposis Coli
Roles of Axin in the Wnt signalling pathway.
Adenomatous Polyposis Coli
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.
Adenomatous Polyposis Coli
Signaling through beta-catenin and Lef/Tcf.
Adenomatous Polyposis Coli
Sporadic medulloblastomas contain oncogenic beta-catenin mutations.
Adenomatous Polyposis Coli
Targeted degradation of beta-catenin by chimeric F-box fusion proteins.
Adenomatous Polyposis Coli
Targeting GSK-3: a promising approach for cancer therapy?
Adenomatous Polyposis Coli
The ?-catenin destruction complex.
Adenomatous Polyposis Coli
The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli.
Adenomatous Polyposis Coli
The control of beta-catenin and TCF during embryonic development and cancer.
Adenomatous Polyposis Coli
The effects of antipsychotics on beta-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats.
Adenomatous Polyposis Coli
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.
Adenomatous Polyposis Coli
The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling.
Adenomatous Polyposis Coli
Thr160 of Axin1 is critical for the formation and function of the ?-catenin destruction complex.
Adenomatous Polyposis Coli
Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.
Adenomatous Polyposis Coli
Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer.
Adenomatous Polyposis Coli
Vital elements of the Wnt-Frizzled signaling pathway in the nervous system.
Adenomatous Polyposis Coli
Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/?-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced colon carcinogenesis.
Adenomatous Polyposis Coli
Wnt signaling: complexity at the surface.
Adenomatous Polyposis Coli
Wnt-independent beta-catenin transactivation in tumor development.
Adenomatous Polyposis Coli
Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta.
Adenomatous Polyposis Coli
[Dynamic changes of adenomatous polyposis coli protein and glycogen synthase kinase 3beta in the repair of the injured airway epithelial cells in smoking mice.]
Adenomatous Polyposis Coli
[Spatial-temporal distribution of glycogen synthase kinase 3beta and adenomatous polyposis coli protein are involved in the injury and repair of airway epithelial cells induced by scratching.]
Adenomatous Polyps
Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.
Adenomatous Polyps
[Determination of cyclic AMP and protein kinases in the diagnosis of colonic tumors]
Adenomatous Polyps
[Peutz-Jeghers Syndrome with Adenomatous Change in a Fifteen-month-old Boy].
Adenomyoepithelioma
Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein.
Adenomyosis
Increased expression of p21-activated kinase 4 in adenomyosis and its regulation of matrix metalloproteinase-2 and -9 in endometrial cells.
Adenomyosis
Linc-ROR promotes endometrial cell proliferation by activating the PI3K-Akt pathway.
Adenomyosis
RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis.
Adenomyosis
[The expression of moesin, p21-activated kinase 4 (PAK 4), matrix metalloproteinases (MMP 2, MMP 9), and CD34 in the eutopic and ectopic endometrium in adenomyosis].
Adenoviridae Infections
Adenovirus E1B 19,000-molecular-weight protein activates c-Jun N-terminal kinase and c-Jun-mediated transcription.
Adenoviridae Infections
Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression.
Adenoviridae Infections
Adenovirus infection targets the cellular protein kinase CK2 and RNA-activated protein kinase (PKR) into viral inclusions of the cell nucleus.
Adenoviridae Infections
Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin.
Adrenal Cortex Neoplasms
Bitter Melon (Momordica charantia) Extract Suppresses Adrenocortical Cancer Cell Proliferation Through Modulation of the Apoptotic Pathway, Steroidogenesis, and Insulin-Like Growth Factor Type 1 Receptor/RAC-? Serine/Threonine-Protein Kinase Signaling.
Adrenocortical Adenoma
ACTH-induced cortisol secretion is mediated by cAMP and PKC in various adrenocortical adenomas.
Adrenocortical Adenoma
Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.
Adrenocortical Adenoma
cAMP signaling in cortisol-producing adrenal adenoma.
Adrenocortical Adenoma
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
Adrenocortical Adenoma
Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas.
Adrenocortical Adenoma
Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?
Adrenocortical Adenoma
Mechanisms of Aberrant PKA Activation by C? Subunit Mutations.
Adrenocortical Adenoma
PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.
Adrenocortical Adenoma
Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.
Adrenocortical Adenoma
Steroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma.
Adrenocortical Carcinoma
Advances in understanding the molecular underpinnings of adrenocortical tumors.
Adrenocortical Carcinoma
Angiotensin II-activated protein kinase D mediates acute aldosterone secretion.
Adrenocortical Carcinoma
Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro.
Adrenocortical Carcinoma
Ataxia telangiectasia mutated germline pathogenic variant in adrenocortical carcinoma.
Adrenocortical Carcinoma
Characterization of a cyclic nucleotide-independent protein kinase highly active in human adrenocortical carcinoma.
Adrenocortical Carcinoma
Cyclic AMP regulates expression of the gene coding for a mouse vas deferens protein related to the aldo-keto reductase superfamily in human and murine adrenocortical cells.
Adrenocortical Carcinoma
Expression and regulation of the lipoprotein lipase gene in human adrenal cortex.
Adrenocortical Carcinoma
Expression of autophosphorylating protein kinase 500 in normal and neoplastic rat cells.
Adrenocortical Carcinoma
Regulation of the scavenger receptor BI and the LDL receptor by activators of aldosterone production, angiotensin II and PMA, in the human NCI-H295R adrenocortical cell line.
Adrenoleukodystrophy
Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP.
African Swine Fever
African swine fever virus encodes a serine protein kinase which is packaged into virions.
Agammaglobulinemia
WHI-131 Promotes Osteoblast Differentiation and Prevents Osteoclast Formation and Resorption in Mice.
Aggressive Periodontitis
Calcium-dependent protein kinase C activity of neutrophils in localized juvenile periodontitis.
AIDS Dementia Complex
Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction.
AIDS-Associated Nephropathy
A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-?1/Smad3 Pathway.
AIDS-Associated Nephropathy
Role of HIPK2 in kidney fibrosis.
AIDS-Associated Nephropathy
Tubular HIPK2 is a key contributor to renal fibrosis.
Albuminuria
Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease.
Albuminuria
GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.
Albuminuria
Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-alpha stimulation, and effects of a phosphodiesterase inhibitor.
Albuminuria
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes.
Albuminuria
Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat.
Albuminuria
Podocyte Injury and Albuminuria in Mice with Podocyte-Specific Overexpression of the Ste20-Like Kinase, SLK.
Albuminuria
ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy.
Alopecia
Treatment review for male pattern hair-loss.
Alopecia
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
alpha-Thalassemia
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Alphavirus Infections
Mayaro virus infection cycle relies on casein kinase 2 activity.
Alveolar Bone Loss
Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss.
Alzheimer Disease
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.
Alzheimer Disease
1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation.
Alzheimer Disease
14-3-3 protein beta isoform is associated with 3-repeat tau neurofibrillary tangles in Alzheimer's disease.
Alzheimer Disease
14-3-3 proteins and zeta isoform containing neurofibrillary tangles in patients with Alzheimer's disease.
Alzheimer Disease
14-3-3 proteins in neurodegeneration.
Alzheimer Disease
14-3-3 Zeta and Tau Genes Interactively Decrease Alzheimer's Disease Risk.
Alzheimer Disease
14-3-3zeta is an effector of tau protein phosphorylation.
Alzheimer Disease
17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner.
Alzheimer Disease
2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3beta with Good Brain Permeability.
Alzheimer Disease
3D-QSAR and Molecular Docking Studies on 3-Anilino-4-Arylmaleimide Derivatives as Glycogen Synthase Kinase-3? Inhibitors.
Alzheimer Disease
3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3beta inhibitors.
Alzheimer Disease
?-Amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3.
Alzheimer Disease
?2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer's disease models.
Alzheimer Disease
A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts.
Alzheimer Disease
A combination extract of Renshen (Panax Ginseng), Yinyanghuo (Herba Epimedii Brevicornus), Yuanzhi (Radix Palygalae) and Jianghuang (Rhizoma Curcumae Longae) decreases glycogen synthase kinase 3beta expression in brain cortex of APPV7171 transgenic mice.
Alzheimer Disease
A high throughput and sensitive method correlates neuronal disorder genotypes to Drosophila larvae crawling phenotypes.
Alzheimer Disease
A longitudinal FDG-PET study of transgenic mice overexpressing GSK-3? in the brain.
Alzheimer Disease
A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.
Alzheimer Disease
A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S?)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.
Alzheimer Disease
A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.
Alzheimer Disease
A quantitative autoradiographic study of [3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.
Alzheimer Disease
A unique type of GSK-3 inhibitor brings new opportunities to the clinic.
Alzheimer Disease
Aberrant casein kinase II in Alzheimer's disease.
Alzheimer Disease
Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.
Alzheimer Disease
Activation of glycogen synthase kinase-3 beta mediates ?-amyloid induced neuritic damage in Alzheimer's disease.
Alzheimer Disease
Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture.
Alzheimer Disease
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.
Alzheimer Disease
Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease.
Alzheimer Disease
Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice.
Alzheimer Disease
Age-related changes in glycogen synthase kinase 3beta (GSK3beta) immunoreactivity in the central nervous system of rats.
Alzheimer Disease
Akt activity in Alzheimer's disease and other neurodegenerative disorders.
Alzheimer Disease
Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations.
Alzheimer Disease
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.
Alzheimer Disease
Alpha 1-Antichymotrypsin, an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer's Disease, Induces Tau Hyperphosphorylation through c-Jun N-Terminal Kinase Activation.
Alzheimer Disease
Alternative splicing of the porcine glycogen synthase kinase 3? (GSK-3?) gene with differential expression patterns and regulatory functions.
Alzheimer Disease
Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.
Alzheimer Disease
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.
Alzheimer Disease
Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.
Alzheimer Disease
American Chemical Society - 240th national meeting - chemistry for preventing and combating disease: part 2.
Alzheimer Disease
AMP-activated protein kinase: a potential player in Alzheimer's disease.
Alzheimer Disease
AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on ?-amyloid clearance.
Alzheimer Disease
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.
Alzheimer Disease
Amyloid Beta 1-42 Inhibits Entorhinal Cortex Gamma Bursts: Role of GSK-3.
Alzheimer Disease
An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.
Alzheimer Disease
Analysis of the LRRK2 G2019S mutation in Alzheimer Disease.
Alzheimer Disease
Analysis of the LRRK2 Gly2385Arg variant in Alzheimer's disease in Taiwan.
Alzheimer Disease
Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase-3 in mouse brain.
Alzheimer Disease
Anti-inflammatory Potential of GSK-3 Inhibitors.
Alzheimer Disease
Antibodies against beta-amyloid reduce abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.
Alzheimer Disease
Apolipoprotein E and beta-amyloid (1-42) regulation of glycogen synthase kinase-3beta.
Alzheimer Disease
Application of an ESI-QTOF method for the detailed characterization of GSK-3? inhibitors.
Alzheimer Disease
Application of graph theory: prediction of glycogen synthase kinase-3 beta inhibitory activity of thiadiazolidinones as potential drugs for the treatment of Alzheimer's disease.
Alzheimer Disease
Association between Glycogen Synthase Kinase-3beta Genetic Polymorphism and Late-Onset Alzheimer's Disease.
Alzheimer Disease
Author Correction: Inhibition of casein kinase 1?/?improves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer's disease.
Alzheimer Disease
A meta-analysis of leucine-rich repeat kinase 2 (LRRK2) polymorphisms in Alzheimer's disease.
Alzheimer Disease
Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease.
Alzheimer Disease
Biochemical characterization of tau protein and its associated syndapin 1 and protein kinase Cepsilon for their functional regulation in rat brain.
Alzheimer Disease
Biochemical investigations in patients with dementia.
Alzheimer Disease
Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases.
Alzheimer Disease
Bioinformatics methods in drug repurposing for Alzheimer's disease.
Alzheimer Disease
c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's Disease.
Alzheimer Disease
c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo.
Alzheimer Disease
c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer's Diseases.
Alzheimer Disease
C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
Alzheimer Disease
Calcium/calmodulin-dependent kinase II and Alzheimer's disease.
Alzheimer Disease
cAMP-dependent protein kinase in cerebral microvessels in aging and Alzheimer disease.
Alzheimer Disease
Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease.
Alzheimer Disease
Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease.
Alzheimer Disease
Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis.
Alzheimer Disease
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Alzheimer Disease
Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain.
Alzheimer Disease
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
Alzheimer Disease
Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer's disease brain.
Alzheimer Disease
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Alzheimer Disease
Casein kinase II alteration precedes tau accumulation in tangle formation.
Alzheimer Disease
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.
Alzheimer Disease
Characterization of Parkinson's disease-related pathogenic TMEM230 mutants.
Alzheimer Disease
Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.
Alzheimer Disease
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.
Alzheimer Disease
CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment.
Alzheimer Disease
Clinical Chemistry Route for Investigation of Alzheimer's Disease: A Label-Free Electrochemiluminescent Biosensor for Glycogen Synthase Kinase-3 Beta.
Alzheimer Disease
Co-occurrence of sporadic parkinsonism and late-onset Alzheimer's disease in a Brazilian male with the LRRK2 p.G2019S mutation.
Alzheimer Disease
Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1.
Alzheimer Disease
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3.
Alzheimer Disease
Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease.
Alzheimer Disease
CSF nonphosphorylated Tau as a biomarker for the discrimination of AD from CJD.
Alzheimer Disease
D-serine Ameliorates Motor and Cognitive Impairments in ?-amyloid 1-42 Injected Mice by Inhibiting JNK Signaling Pathway.
Alzheimer Disease
DAPK1 is Associated with FTD and not with Alzheimer's Disease.
Alzheimer Disease
Death-Associated Protein Kinase 1 As A Promising Drug Target In Cancer and Alzheimer's Disease.
Alzheimer Disease
Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.
Alzheimer Disease
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Alzheimer Disease
Decreased cyclin dependent kinase in brain of patients with Down syndrome.
Alzheimer Disease
Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.
Alzheimer Disease
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice.
Alzheimer Disease
Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin.
Alzheimer Disease
Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats.
Alzheimer Disease
Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5.
Alzheimer Disease
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Alzheimer Disease
Design, Bio-evaluation and Molecular Dynamics Simulation of Novel GSK-3? Inhibitors.
Alzheimer Disease
Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.
Alzheimer Disease
Designing of dual inhibitors for GSK-3? and CDK5: Virtual screening and in vitro biological activities study.
Alzheimer Disease
Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay.
Alzheimer Disease
Determination of kinetic parameters and structure-activity relationships of ginsenosides as inhibitors of cyclin-dependent kinase 5/p25 using ultra-pressure liquid chromatography with triple quadrupole tandem mass spectrometry.
Alzheimer Disease
Determining association of rho kinase 1 gene polymorphisms with risk of Alzheimer's disease: a multicenter pilot study.
Alzheimer Disease
Development of a Cellular Tau Enzyme-Linked Immunosorbent Assay Method for Screening GSK-3? Inhibitors.
Alzheimer Disease
Diagnosis associated with Tau higher than 1200?pg/mL: Insights from the clinical and laboratory practice.
Alzheimer Disease
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.
Alzheimer Disease
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Alzheimer Disease
Disparate Effects of Lithium and a GSK-3 Inhibitor on Neuronal Oscillatory Activity in Prefrontal Cortex and Hippocampus.
Alzheimer Disease
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.
Alzheimer Disease
Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
Alzheimer Disease
Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.
Alzheimer Disease
DNA damage responses in neural cells: Focus on the telomere.
Alzheimer Disease
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Alzheimer Disease
Does lithium prevent Alzheimer's disease?
Alzheimer Disease
Does oxidatively damaged DNA drive amyloid-? generation in Alzheimer's disease? A hypothesis.
Alzheimer Disease
Downregulation of 14-3-3 Proteins in Alzheimer's Disease.
Alzheimer Disease
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in adult brain.
Alzheimer Disease
Dynamic range of GSK3? not GSK3? is essential for bidirectional synaptic plasticity at hippocampal CA3-CA1 synapses.
Alzheimer Disease
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.
Alzheimer Disease
Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.
Alzheimer Disease
Effect of glycogen synthase kinase 3 ?-mediated presenilin 1 phosphorylation on amyloid ? production is negatively regulated by insulin receptor cleavage.
Alzheimer Disease
Effect of GSK-3 overactivation on neurofilament phosphorylation.
Alzheimer Disease
Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.
Alzheimer Disease
Effect of truncated-ApoE4 overexpression on tau phosphorylation in cultured N2a cells.
Alzheimer Disease
Effects of a Glycogen Synthase Kinase 3 Inhibitor Tideglusib on Bone Regeneration With Calvarial Defects.
Alzheimer Disease
Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice.
Alzheimer Disease
Efficacy and Safety of Glycogen Synthase Kinase 3 Inhibitors for Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Alzheimer Disease
Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair.
Alzheimer Disease
Elevation of casein kinase 1? associated with TDP-43 and tau pathologies in Alzheimer's disease.
Alzheimer Disease
Enantioselective synthesis of the novel chiral sulfoxide derivative as a glycogen synthase kinase 3beta inhibitor.
Alzheimer Disease
Enhanced expression of 14-3-3 proteins in reactive astrocytes in Creutzfeldt-Jakob disease brains.
Alzheimer Disease
Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk.
Alzheimer Disease
Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A.
Alzheimer Disease
Everolimus, a mammalian target of rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in male rats.
Alzheimer Disease
Evidence for irreversible inhibition of glycogen synthase kinase-3? by tideglusib.
Alzheimer Disease
Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation.
Alzheimer Disease
Expression of 14-3-3 transcript isoforms in response to ethanol exposure and their regulation by miRNAs.
Alzheimer Disease
Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection.
Alzheimer Disease
First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease.
Alzheimer Disease
Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production.
Alzheimer Disease
Flow cytometry-based method to analyze the change in Tau phosphorylation in a hGSK-3beta and hTau over-expressing EcR-293 cell line.
Alzheimer Disease
Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models.
Alzheimer Disease
Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.
Alzheimer Disease
Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond.
Alzheimer Disease
Gene-BIT Life Sciences' third annual world congress. Anti-neurodegenerative and anti-inflammation biotherapeutics.
Alzheimer Disease
Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk.
Alzheimer Disease
Glia maturation factor overexpression in neuroblastoma cells activates glycogen synthase kinase-3beta and caspase-3.
Alzheimer Disease
Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.
Alzheimer Disease
Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles.
Alzheimer Disease
Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation.
Alzheimer Disease
Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.
Alzheimer Disease
Glycogen synthase kinase 3: a key regulator of cellular fate.
Alzheimer Disease
Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target?
Alzheimer Disease
Glycogen synthase kinase 3: an emerging therapeutic target.
Alzheimer Disease
Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance.
Alzheimer Disease
Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review.
Alzheimer Disease
Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.
Alzheimer Disease
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.
Alzheimer Disease
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics.
Alzheimer Disease
Glycogen synthase kinase-3 as a key regulator of cognitive function.
Alzheimer Disease
Glycogen synthase kinase-3 as drug target: from wallflower to center of attention.
Alzheimer Disease
Glycogen synthase kinase-3 beta and tau genes interact in Parkinson's and Alzheimer's diseases.
Alzheimer Disease
Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: lessons from lithium.
Alzheimer Disease
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.
Alzheimer Disease
Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking.
Alzheimer Disease
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Alzheimer Disease
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.
Alzheimer Disease
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease.
Alzheimer Disease
Glycogen Synthase Kinase-3 Maleimide Inhibitors As Potential PET-Tracers for Imaging Alzheimer's Disease: 11C-Synthesis and In Vivo Proof of Concept.
Alzheimer Disease
Glycogen Synthase Kinase-3 Modulates Neurite Outgrowth in Cultured Neurons: Possible Implications for Neurite Pathology in Alzheimer's Disease.
Alzheimer Disease
Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.
Alzheimer Disease
Glycogen synthase kinase-3 signaling in Alzheimer's disease.
Alzheimer Disease
Glycogen synthase kinase-3: a target for novel bipolar disorder treatments.
Alzheimer Disease
Glycogen synthase kinase-3: The missing link to aberrant circuit function in disorders of cognitive dysfunction?
Alzheimer Disease
Glycogen synthase kinase-3?2 has lower phosphorylation activity to tau than glycogen synthase kinase-3?1.
Alzheimer Disease
Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease.
Alzheimer Disease
Glycogen synthase kinase-3beta is complexed with tau protein in brain microtubules.
Alzheimer Disease
Granulovacuolar Degeneration Bodies of Alzheimer's Disease Resemble Late-stage Autophagic Organelles.
Alzheimer Disease
GSK-3 and lysosomes meet in Alzheimer's disease.
Alzheimer Disease
GSK-3 and Tau: A Key Duet in Alzheimer's Disease.
Alzheimer Disease
GSK-3 as potential target for therapeutic intervention in cancer.
Alzheimer Disease
GSK-3 in Neurodegenerative Diseases.
Alzheimer Disease
GSK-3 Inhibitors and Tooth Repair: An Ethical Analysis.
Alzheimer Disease
GSK-3 inhibitors for Alzheimer's disease.
Alzheimer Disease
GSK-3 Inhibitors: A new class of drugs for Alzheimer's Disease Treatment.
Alzheimer Disease
GSK-3 inhibitors: discoveries and developments.
Alzheimer Disease
GSK-3 is essential in the pathogenesis of Alzheimer's disease.
Alzheimer Disease
GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration.
Alzheimer Disease
GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.
Alzheimer Disease
GSK-3: a key player in neurodegeneration and memory.
Alzheimer Disease
GSK-3: tricks of the trade for a multi-tasking kinase.
Alzheimer Disease
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.
Alzheimer Disease
GSK-3beta is required for memory reconsolidation in adult brain.
Alzheimer Disease
GSK3 and p53 - is there a link in Alzheimer's disease?
Alzheimer Disease
GSK3 and Tau: Two Convergence Points in Alzheimer's Disease.
Alzheimer Disease
GSK3 inhibition promotes lysosomal biogenesis and the autophagic degradation of the Amyloid-? Precursor Protein.
Alzheimer Disease
GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals.
Alzheimer Disease
GSK3beta activity modifies the localization and function of presenilin 1.
Alzheimer Disease
GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity.
Alzheimer Disease
GSK3beta signalling: casting a wide net in Alzheimer's disease.
Alzheimer Disease
GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease.
Alzheimer Disease
HDAC6 regulates mitochondrial transport in hippocampal neurons.
Alzheimer Disease
Highly Potent and Specific GSK-3beta Inhibitors That Block Tau Phosphorylation and Decrease alpha-Synuclein Protein Expression in a Cellular Model of Parkinson's Disease.
Alzheimer Disease
Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.
Alzheimer Disease
Identification of Bombyx mori 14-3-3 orthologs and the interactor Hsp60.
Alzheimer Disease
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3?.
Alzheimer Disease
Identification of lead small molecule inhibitors of glycogen synthase kinase-3 beta using a fragment-linking strategy.
Alzheimer Disease
Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 beta gene and promoter in late onset Alzheimer's disease.
Alzheimer Disease
Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.
Alzheimer Disease
Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells.
Alzheimer Disease
In silico docking and comparative ADMET profile of different glycogen synthase kinase 3 beta inhibitors as the potential leads for the development of anti-Alzheimer drug therapy.
Alzheimer Disease
In Vitro and In Vivo Evaluation of GSK-3 Radioligands in Alzheimer's Disease: Preliminary Evidence of Sex Differences.
Alzheimer Disease
In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta.
Alzheimer Disease
In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors.
Alzheimer Disease
Inactivation of GSK-3beta in okadaic acid-induced neurodegeneration: relevance to Alzheimer's disease.
Alzheimer Disease
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
Alzheimer Disease
Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.
Alzheimer Disease
Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down syndrome.
Alzheimer Disease
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology.
Alzheimer Disease
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Alzheimer Disease
Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.
Alzheimer Disease
Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice.
Alzheimer Disease
Inhibition of casein kinase 1?/?improves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer's disease.
Alzheimer Disease
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3 ameliorates ?-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3: an emerging target in the treatment of traumatic brain injury.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity.
Alzheimer Disease
Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.
Alzheimer Disease
Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3?
Alzheimer Disease
Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation.
Alzheimer Disease
Insight into glycogen synthase kinase-3? inhibitory activity of phyto-constituents from Melissa officinalis: in silico studies.
Alzheimer Disease
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.
Alzheimer Disease
Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.
Alzheimer Disease
Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
Alzheimer Disease
Is Glucagon-like peptide-1, an agent treating diabetes, a new hope for Alzheimer's disease?
Alzheimer Disease
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Alzheimer Disease
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.
Alzheimer Disease
Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer's disease by elevating microRNA-15a and repressing ROCK1 expression.
Alzheimer Disease
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Alzheimer Disease
Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease.
Alzheimer Disease
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Alzheimer Disease
Ligand binding study of human PEBP1/RKIP: interaction with nucleotides and Raf-1 peptides evidenced by NMR and mass spectrometry.
Alzheimer Disease
Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.
Alzheimer Disease
Lithium for older adults with bipolar disorder: Should it still be considered a first-line agent?
Alzheimer Disease
Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.
Alzheimer Disease
Lithium Inhibits GSK3? and Augments GluN2A Receptor Expression in the Prefrontal Cortex.
Alzheimer Disease
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles.
Alzheimer Disease
Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.
Alzheimer Disease
Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study.
Alzheimer Disease
Lithium, a potential protective drug in Alzheimer's disease.
Alzheimer Disease
Lithium: bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium.
Alzheimer Disease
Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease.
Alzheimer Disease
Loss of activated CaMKII at the synapse underlies Alzheimer's disease memory loss.
Alzheimer Disease
LRRK2 and neurodegeneration.
Alzheimer Disease
LRRK2 G2019S and I2020T mutations are not common in Alzheimer's disease and vascular dementia.
Alzheimer Disease
LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8.
Alzheimer Disease
LRRK2 mutations are not common in Alzheimer's disease.
Alzheimer Disease
LRRK2 p.G2019S mutation is not common among Alzheimer's disease patients in Brazil.
Alzheimer Disease
LRRK2 variant associated with Alzheimer's disease.
Alzheimer Disease
Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model.
Alzheimer Disease
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.
Alzheimer Disease
MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration.
Alzheimer Disease
Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells.
Alzheimer Disease
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Alzheimer Disease
Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain.
Alzheimer Disease
Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.
Alzheimer Disease
Memantine Inhibits Calpain-Mediated Truncation of GSK-3 Induced by NMDA: Implications in Alzheimer's Disease.
Alzheimer Disease
microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.
Alzheimer Disease
MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease.
Alzheimer Disease
MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation via Coregulating BACE1 and PRKACB.
Alzheimer Disease
MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease.
Alzheimer Disease
Microsecond molecular dynamics simulations and dynamic network analysis provide understanding of the allosteric inactivation of GSK3? induced by the L343R mutation.
Alzheimer Disease
Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells.
Alzheimer Disease
Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.
Alzheimer Disease
Molecular dynamics simulation studies of GSK-3? ATP competitive inhibitors: understanding the factors contributing to selectivity.
Alzheimer Disease
Molecular mechanisms of axon specification and neuronal disorders.
Alzheimer Disease
Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease.
Alzheimer Disease
Multifunctional Ligands with Glycogen Synthase Kinase 3 Inhibitory Activity as a New Direction in Drug Research for Alzheimer's Disease.
Alzheimer Disease
Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease.
Alzheimer Disease
Mutation analysis of patients with neurodegenerative disorders using NeuroX array.
Alzheimer Disease
N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.
Alzheimer Disease
Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms.
Alzheimer Disease
Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets.
Alzheimer Disease
Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins.
Alzheimer Disease
Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.
Alzheimer Disease
Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide.
Alzheimer Disease
Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.
Alzheimer Disease
Neurotrophins enhance CaMKII activity and rescue amyloid-?-induced deficits in hippocampal synaptic plasticity.
Alzheimer Disease
New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.
Alzheimer Disease
Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer's disease.
Alzheimer Disease
NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy.
Alzheimer Disease
No association between the LRRK2 G2019S mutation and Alzheimer's disease in Italy.
Alzheimer Disease
No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals.
Alzheimer Disease
Novel 18F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3?.
Alzheimer Disease
Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease.
Alzheimer Disease
Novel GSK-3beta inhibitors from sequential virtual screening.
Alzheimer Disease
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.
Alzheimer Disease
O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Alzheimer Disease
Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice.
Alzheimer Disease
Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer's disease and cerebral amyloid angiopathy.
Alzheimer Disease
p70 S6 kinase and tau in Alzheimer's disease.
Alzheimer Disease
Pathological tau tangles localize to focal cortical dysplasia in older patients.
Alzheimer Disease
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.
Alzheimer Disease
Pharmacological inhibitors of glycogen synthase kinase 3.
Alzheimer Disease
Pharmacophore feature-based virtual screening for finding potent GSK-3 inhibitors using molecular docking and dynamics simulations.
Alzheimer Disease
Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.
Alzheimer Disease
Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation.
Alzheimer Disease
Phosphorylation of tau by glycogen synthase kinase-3 beta in vitro produces species with similar electrophoretic and immunogenic properties to PHF-tau from Alzheimer's disease brain.
Alzheimer Disease
Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry.
Alzheimer Disease
Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.
Alzheimer Disease
Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease.
Alzheimer Disease
PLS and shape-based similarity analysis of maleimides - GSK-3 inhibitors.
Alzheimer Disease
Potential mechanisms involved in the prevention of neurodegenerative diseases by lithium.
Alzheimer Disease
Potential of casein kinase I in digestive cancer screening.
Alzheimer Disease
Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.
Alzheimer Disease
Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures.
Alzheimer Disease
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.
Alzheimer Disease
Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.
Alzheimer Disease
Pretreatment with 5-hydroxymethyl-2-furaldehyde blocks scopolamine-induced learning deficit in contextual and spatial memory in male mice.
Alzheimer Disease
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Alzheimer Disease
Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells.
Alzheimer Disease
Protein kinases A and C regulate amyloid-? degradation by modulating protein levels of neprilysin and insulin-degrading enzyme in astrocytes.
Alzheimer Disease
Purification of CK1 by affinity chromatography on immobilised axin.
Alzheimer Disease
Purification of GSK-3 by affinity chromatography on immobilized axin.
Alzheimer Disease
Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.
Alzheimer Disease
Radiosynthesis and in Vivo Evaluation of [(11)C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain.
Alzheimer Disease
Raf inhibitors as therapeutic agents against neurodegenerative diseases.
Alzheimer Disease
Rapid modulation of TRH and TRH-like peptide levels in rat brain and peripheral tissues by corticosterone.
Alzheimer Disease
Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor.
Alzheimer Disease
Rapidly progressive Alzheimer's disease and elevated 14-3-3 proteins in cerebrospinal fluid.
Alzheimer Disease
Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease.
Alzheimer Disease
Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders.
Alzheimer Disease
Receptor-based pharmacophore modeling, virtual screening, and molecular docking studies for the discovery of novel GSK-3? inhibitors.
Alzheimer Disease
Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Reduction of NR1 and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease.
Alzheimer Disease
Regulation and role of brain calcium/calmodulin-dependent protein kinase II.
Alzheimer Disease
Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I.
Alzheimer Disease
Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3.
Alzheimer Disease
Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease.
Alzheimer Disease
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention.
Alzheimer Disease
Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.
Alzheimer Disease
Retracted: "Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer's disease and cerebral amyloid angiopathy" [Neuroscience 146 (2007) 1640-1651].
Alzheimer Disease
Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-? levels in brain.
Alzheimer Disease
Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors.
Alzheimer Disease
Role of GSK-3beta activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene.
Alzheimer Disease
Role of protein kinase B in Alzheimer's neurofibrillary pathology.
Alzheimer Disease
Roles of Glycogen synthase kinase 3 in Alzheimer's disease.
Alzheimer Disease
Rs4878104 contributes to Alzheimer's disease risk and regulates DAPK1 gene expression.
Alzheimer Disease
S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease.
Alzheimer Disease
Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 ? Inhibitors.
Alzheimer Disease
Screening of potential drug for Alzheimer's disease: a computational study with GSK-3 ? inhibition through virtual screening, docking, and molecular dynamics simulation.
Alzheimer Disease
Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin is associated with decreased phosphorylation of Ser glycogen synthase kinase-3beta.
Alzheimer Disease
Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.
Alzheimer Disease
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.
Alzheimer Disease
Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells.
Alzheimer Disease
Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models.
Alzheimer Disease
Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3? signaling pathway.
Alzheimer Disease
Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice.
Alzheimer Disease
Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments.
Alzheimer Disease
SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation.
Alzheimer Disease
Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Alzheimer Disease
Steroid-responsive encephalopathy with a peculiar CSF biomarker profile in an 89-year-old man.
Alzheimer Disease
Structural Basis for Achieving GSK-3? Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery.
Alzheimer Disease
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Alzheimer Disease
Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta.
Alzheimer Disease
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
Alzheimer Disease
Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3? inhibitors: A critical review.
Alzheimer Disease
Structure-based approaches in the design of GSK-3 selective inhibitors.
Alzheimer Disease
Structure-based optimization of oxadiazole-based GSK-3 inhibitors.
Alzheimer Disease
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Alzheimer Disease
Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors.
Alzheimer Disease
Suppression of Plasmodium berghei parasitemia by LiCl in an animal infection model.
Alzheimer Disease
Suppressive Effects of SuHeXiang Wan on Amyloid-?42-Induced Extracellular Signal-Regulated Kinase Hyperactivation and Glial Cell Proliferation in a Transgenic Drosophila Model of Alzheimer's Disease.
Alzheimer Disease
Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: An fast and atom efficient access to 1-aryl-3-benzylureas.
Alzheimer Disease
Synthesis and biological evaluation of novel 2 (4`-hydroxynaphthyl) chromen-4-one as a CK2 inhibitor.
Alzheimer Disease
Synthesis of carbon-11-labeled isonicotinamides as new potential PET agents for imaging of GSK-3 enzyme in Alzheimer's disease.
Alzheimer Disease
Systematic analysis of GSK-3 signaling pathways in aging of cerebral tissue.
Alzheimer Disease
Targeting disease through novel pathways of apoptosis and autophagy.
Alzheimer Disease
Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders.
Alzheimer Disease
Tau and GSK3beta dephosphorylations are required for regulating Pin1 phosphorylation.
Alzheimer Disease
Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.
Alzheimer Disease
tau kinases in the rat heat shock model: possible implications for Alzheimer disease.
Alzheimer Disease
Tau overexpression in transgenic mice induces glycogen synthase kinase 3beta and beta-catenin phosphorylation.
Alzheimer Disease
Tau phosphorylation by GSK-3beta promotes tangle-like filament morphology.
Alzheimer Disease
Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Alzheimer Disease
Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.
Alzheimer Disease
Tau-tubulin kinase 1 and amyloid-? peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models.
Alzheimer Disease
Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain.
Alzheimer Disease
Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease.
Alzheimer Disease
The ?-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer's Disease.
Alzheimer Disease
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease.
Alzheimer Disease
The ALS/PDC syndrome of Guam and the cycad hypothesis.
Alzheimer Disease
The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions.
Alzheimer Disease
The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of Alzheimer disease suggesting a correlation between ocular and brain pathologies.
Alzheimer Disease
The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients.
Alzheimer Disease
The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease.
Alzheimer Disease
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Alzheimer Disease
The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.
Alzheimer Disease
The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease.
Alzheimer Disease
The LRRK2 R1628P Variant Plays a Protective Role in Han Chinese Population with Alzheimer's Disease.
Alzheimer Disease
The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.
Alzheimer Disease
The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.
Alzheimer Disease
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
Alzheimer Disease
The neurite retraction induced by lysophosphatidic acid increases Alzheimer's disease-like Tau phosphorylation.
Alzheimer Disease
The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo.
Alzheimer Disease
The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents.
Alzheimer Disease
Therapeutic Targeting of Casein Kinase 1?/? in an Alzheimer's Disease Mouse Model.
Alzheimer Disease
Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study.
Alzheimer Disease
Tumor Necrosis Factor-Induced Cerebral Insulin Resistance in Alzheimer's Disease Links Numerous Treatment Rationales.
Alzheimer Disease
Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy.
Alzheimer Disease
Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes.
Alzheimer Disease
Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?
Alzheimer Disease
Up-regulation of casein kinase 1? is involved in tau pathogenesis in Alzheimer's disease.
Alzheimer Disease
Up-regulation of Hypoxia-Inducible Factor (HIF) -1alpha and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30.
Alzheimer Disease
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease.
Alzheimer Disease
Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling.
Alzheimer Disease
Withaferin A Regulates LRRK2 Levels by Interfering with the Hsp90- Cdc37 Chaperone Complex.
Alzheimer Disease
Yeast 14-3-3 proteins.
Alzheimer Disease
[A new target for diabetes therapy: advances in the research of glycogen synthase kinase-3 inhibitors]
Alzheimer Disease
[Cytoplasmic casein kinase 2 and its substrate proteins in the brain in Alzheimer's disease]
Alzheimer Disease
[Effects of tanshinone IIA on the expressions of caspase-3, Akt and NF-?B in the brains of rat models of Alzheimer's disease].
Alzheimer Disease
[Eleven years of autopsy on account of Creutzfeldt-Jakob disease in the Netherlands]
Alzheimer Disease
[Protein phosphorylation in the normal nervous system and in Alzheimer's disease]
Alzheimer Disease
[The role of lithium in neurodegenerative diseases: new registries for old actors.]
Amebiasis
EhP3, a homolog of 14-3-3 family of protein participates in actin reorganization and phagocytosis in Entamoeba histolytica.
Ameloblastoma
Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review.
Amnesia
Possible interaction of hippocampal nitric oxide and calcium/calmodulin-dependent protein kinase II on reversal of spatial memory impairment induced by morphine.
Amnesia
Status of the "protein kinase CK2-HMG14" system in age-related amnesia in rats.
Amnesia, Retrograde
Systemic administration of ACTH or vasopressin reverses the amnestic effect of posttraining beta-endorphin or electroconvulsive shock but not that of intrahippocampal infusion of protein kinase inhibitors.
amp deaminase deficiency
AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.
Amyloidosis
Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice.
Amyloidosis
Proteome analysis of cerebrospinal fluid in Guillain-Barré syndrome (GBS).
Amyotrophic Lateral Sclerosis
14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
14-3-3 proteins in Lewy body-like hyaline inclusions in a patient with familial amyotrophic lateral sclerosis with a two-base pair deletion in the Cu/Zn superoxide dismutase (SOD1) gene.
Amyotrophic Lateral Sclerosis
14-3-3 proteins in Lewy body-like hyaline inclusions in patients with sporadic amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
14-3-3 proteins in neurodegeneration.
Amyotrophic Lateral Sclerosis
A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord.
Amyotrophic Lateral Sclerosis
Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Amyotrophic Lateral Sclerosis
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Amyotrophic Lateral Sclerosis
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.
Amyotrophic Lateral Sclerosis
Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model.
Amyotrophic Lateral Sclerosis
Computer-aided scaffold hopping to identify a novel series of casein kinase 1 delta (CK1d) inhibitors for amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Amyotrophic Lateral Sclerosis
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Amyotrophic Lateral Sclerosis
Immunohistochemical expression of IGF-I and GSK in the spinal cord of Kii and Guamanian ALS patients.
Amyotrophic Lateral Sclerosis
Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS.
Amyotrophic Lateral Sclerosis
Novel group-based QSAR and combinatorial design of CK-1? inhibitors as neuroprotective agents.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Amyotrophic Lateral Sclerosis
Pathogenic Lrrk2 substitutions and Amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies.
Amyotrophic Lateral Sclerosis
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention.
Amyotrophic Lateral Sclerosis
Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.
Amyotrophic Lateral Sclerosis
Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 ? Inhibitors.
Amyotrophic Lateral Sclerosis
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
Amyotrophic Lateral Sclerosis
The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions.
Amyotrophic Lateral Sclerosis
The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.
Amyotrophic Lateral Sclerosis
The potential role of glycogen synthase kinase 3 inhibitors as amyotrophic lateral sclerosis pharmacological therapy.
Amyotrophic Lateral Sclerosis
[Clinical molecular genetics for PARK8 (LRRK2)]
Anaphylaxis
ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.
Anaplasmosis
Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection.
Anemia
Chk1 haploinsufficiency results in anemia and defective erythropoiesis.
Anemia
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response.
Anemia
p27(KIP1) and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice.
Anemia
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival.
Anemia
Protein kinases and membrane protein phosphorylation in normal and abnormal human erythrocytes: variation related to mean cell age.
Anemia, Hemolytic
ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.
Anemia, Sickle Cell
Protein kinases and membrane protein phosphorylation in normal and abnormal human erythrocytes: variation related to mean cell age.
Aneurysm
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Aneurysm
[Effect of thyroxine on the expression of HIF-1? after aneurysmal subarachnoid hemorrhage in rat brain and its mechanism].
Aneurysm, Dissecting
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Angiolipoma
Frequent low-level mutations of protein kinase D2 in angiolipoma.
Angiomyolipoma
Brain tumor formation in tuberous sclerosis depends on Erk activation.
Angiomyolipoma
Incremental Expression of 14-3-3 Protein Beta/Alpha in Urine Correlates with Advanced Stage and Poor Survival in Patients with Clear Cell Renal Cell Carcinoma.
Angiomyolipoma
Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma.
Anhedonia
?CaMKII in lateral habenula mediates core symptoms of depression.
Ankylosis
JNK phosphorylation promotes degeneration of cervical endplate chondrocytes through down-regulation of the expression of ANK in humans.
Anosmia
A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Anosmia
Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study.
Anosmia
Clinical and Imaging Markers of Prodromal Parkinson's Disease.
Anosmia
Cognition among individuals along a spectrum of increased risk for Parkinson's disease.
Anosmia
Olfactory deficits and cardiac (123) I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations.
Anovulation
Effects of seasonal adiposity on ovarian activity of Vespertilionid bat, Scotophilus heathi: proteomics analysis.
Anthrax
Cell entry and cAMP imaging of anthrax edema toxin.
Anthrax
Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages.
Anthrax
Regulatory interactions of a virulence-associated serine/threonine phosphatase-kinase pair in Bacillus anthracis.
Anthrax
The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells.
Aortic Aneurysm
Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.
Aortic Aneurysm
Curcumin attenuates rat thoracic aortic aneurysm formation by inhibition of the c-Jun N-terminal kinase pathway and apoptosis.
Aortic Aneurysm
Effect of miR-126 on the Proliferation and Migration of Vascular Smooth Muscle Cells in Aortic Aneurysm Mice Under PI3K/AKT/mTOR Signaling Pathway.
Aortic Aneurysm
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Aortic Aneurysm
Rosiglitazone negatively regulates c-Jun N-terminal kinase and toll-like receptor 4 proinflammatory signalling during initiation of experimental aortic aneurysms.
Aortic Aneurysm, Abdominal
Curcumin attenuates rat thoracic aortic aneurysm formation by inhibition of the c-Jun N-terminal kinase pathway and apoptosis.
Aortic Aneurysm, Abdominal
Fucoidan attenuates angiotensin II-induced abdominal aortic aneurysms through the inhibition of c-Jun N-terminal kinase and nuclear factor ?B activation.
Aortic Aneurysm, Abdominal
Identification of c-Jun N-terminal kinase as a therapeutic target for abdominal aortic aneurysm.
Aortic Aneurysm, Abdominal
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice.
Aortic Aneurysm, Abdominal
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase.
Aortic Aneurysm, Abdominal
SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration.
Aortic Aneurysm, Thoracic
14-3-3 in Thoracic Aortic Aneurysms: Identification of a Novel Autoantigen in Large Vessel Vasculitis.
Aortic Aneurysm, Thoracic
Curcumin attenuates rat thoracic aortic aneurysm formation by inhibition of the c-Jun N-terminal kinase pathway and apoptosis.
Aortic Aneurysm, Thoracic
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Aortic Diseases
14-3-3?-TRAF5 axis governs interleukin-17A signaling.
Aortic Diseases
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Aortic Valve Disease
High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1.
Aortic Valve Insufficiency
Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, ?-arrestin-2, and CaMKII in mice with aortic regurgitation.
Aphasia, Primary Progressive
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Aphasia, Primary Progressive
Corticobasal syndrome and primary progressive aphasia as manifestations of lrrk2 gene mutations.
Apnea
A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction.
Apnea
Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes.
Apraxias
Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1.
Arrhythmias, Cardiac
AKAP5 anchors PKA to enhance regulation of the HERG channel.
Arrhythmias, Cardiac
Antiarrhythmogenic effect of reconstituted high-density lipoprotein against ischemia/reperfusion in rats.
Arrhythmias, Cardiac
Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits KATP channels through CaMKII activation.
Arrhythmias, Cardiac
Calcium/Calmodulin-dependent Kinase II Regulation of Cardiac Ion Channels.
Arrhythmias, Cardiac
Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.
Arrhythmias, Cardiac
Calm down when the heart is stressed: Inhibiting calmodulin-dependent protein kinase II for antiarrhythmias.
Arrhythmias, Cardiac
Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.
Arrhythmias, Cardiac
CaMKII activation promotes cardiac electrical remodeling and increases the susceptibility to arrhythmia induction in high fat diet-fed mice with hyperlipidemia conditions.
Arrhythmias, Cardiac
CaMKII Activation Promotes Cardiac Electrical Remodeling and Increases the Susceptibility to Arrhythmia Induction in High-fat Diet-Fed Mice With Hyperlipidemia Conditions: Erratum.
Arrhythmias, Cardiac
CaMKII and its role in cardiac arrhythmia.
Arrhythmias, Cardiac
CaMKII as a target for arrhythmia suppression.
Arrhythmias, Cardiac
CaMKII blockade, cardiac conduction, and arrhythmia.
Arrhythmias, Cardiac
CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice.
Arrhythmias, Cardiac
CaMKII inhibitors: from research tools to therapeutic agents.
Arrhythmias, Cardiac
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Arrhythmias, Cardiac
CaMKII-dependent late Na+ current increases electrical dispersion and arrhythmia in ischemia-reperfusion.
Arrhythmias, Cardiac
Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators.
Arrhythmias, Cardiac
Cardiac CaMKII? and Wenxin Keli Prevents Ang II-Induced Cardiomyocyte Hypertrophy by Modulating CnA-NFATc4 and Inflammatory Signaling Pathways in H9c2 Cells.
Arrhythmias, Cardiac
Computational biology in the study of cardiac ion channels and cell electrophysiology.
Arrhythmias, Cardiac
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
Arrhythmias, Cardiac
Disruption of calcium homeostasis by cardiac-specific over-expression of PPAR-? in mice: A role in ventricular arrhythmia.
Arrhythmias, Cardiac
Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function.
Arrhythmias, Cardiac
Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.
Arrhythmias, Cardiac
Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Arrhythmias, Cardiac
Glioblastoma following treatment with fingolimod for relapsing-remitting multiple sclerosis.
Arrhythmias, Cardiac
High Level of Real Urban Air Pollution Promotes Cardiac Arrhythmia in Healthy Mice.
Arrhythmias, Cardiac
HMMerThread: Detecting Remote, Functional Conserved Domains in Entire Genomes by Combining Relaxed Sequence-Database Searches with Fold Recognition.
Arrhythmias, Cardiac
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes.
Arrhythmias, Cardiac
Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways.
Arrhythmias, Cardiac
Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor.
Arrhythmias, Cardiac
Integrated mechanisms of CaMKII-dependent ventricular remodeling.
Arrhythmias, Cardiac
KN-93, A CaMKII inhibitor, suppresses ventricular arrhythmia induced by LQT2 without decreasing TDR.
Arrhythmias, Cardiac
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Arrhythmias, Cardiac
Maximum phosphorylation of the cardiac ryanodine receptor at serine-2809 by protein kinase a produces unique modifications to channel gating and conductance not observed at lower levels of phosphorylation.
Arrhythmias, Cardiac
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Arrhythmias, Cardiac
Multiple downstream proarrhythmic targets for calmodulin kinase II: moving beyond an ion channel-centric focus.
Arrhythmias, Cardiac
NADPH oxidase 4 induces cardiac arrhythmic phenotype in zebrafish.
Arrhythmias, Cardiac
Novel therapy for heart failure and exercise-induced ventricular tachycardia based on 'fixing' the leak in ryanodine receptors.
Arrhythmias, Cardiac
Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.
Arrhythmias, Cardiac
Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.
Arrhythmias, Cardiac
Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia.
Arrhythmias, Cardiac
Proarrhythmic defects in Timothy syndrome require calmodulin kinase II.
Arrhythmias, Cardiac
QT interval prolongation and arrhythmia: an unbreakable connection?
Arrhythmias, Cardiac
Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits.
Arrhythmias, Cardiac
Research progress on the role of CaMKII in heart disease.
Arrhythmias, Cardiac
Role of CaMKII in cardiac arrhythmias.
Arrhythmias, Cardiac
Role of CaMKII in cardiovascular health, disease, and arrhythmia.
Arrhythmias, Cardiac
Sustained CaMKII activity mediates transient oxidative stress-induced long-term facilitation of L-type Ca(2+) current in cardiomyocytes.
Arrhythmias, Cardiac
The Histidine-Rich Calcium Binding Protein in Regulation of Cardiac Rhythmicity.
Arrhythmias, Cardiac
The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet.
Arrhythmias, Cardiac
The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart.
Arrhythmias, Cardiac
Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia.
Arrhythmias, Cardiac
Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction.
Arrhythmias, Cardiac
[Endogenous nocciceptin/orphanin FQ affect ischemic arrhythmias in rats through Raf kinase inhibitor protein].
Arsenic Poisoning
Differential expression of serum proteins in rats subchronically exposed to arsenic identified by iTRAQ-based proteomic technology-14-3-3 ? protein to serve as a potential biomarker.
Arteriosclerosis Obliterans
Drug discovery by formulation design and innovative drug delivery systems (DDS).
Arteriovenous Malformations
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Arteritis
Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.
Arteritis
Coronavirus interactions with the cellular autophagy machinery.
Arthritis
"Jnking" atherosclerosis.
Arthritis
A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.
Arthritis
Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis.
Arthritis
BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.
Arthritis
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.
Arthritis
Critical role of calcitonin gene-related peptide 1 receptors in the amygdala in synaptic plasticity and pain behavior.
Arthritis
Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition.
Arthritis
Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior.
Arthritis
Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse.
Arthritis
Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3.
Arthritis
Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening.
Arthritis
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
Arthritis
In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists.
Arthritis
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
Arthritis
Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue.
Arthritis
Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis.
Arthritis
JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis.
Arthritis
JNK1 is not essential for TNF-mediated joint disease.
Arthritis
Joint NOD2/RIPK2 signaling regulates IL-17 axis and contributes to the development of experimental arthritis.
Arthritis
MAPK signalling in rheumatoid joint destruction: can we unravel the puzzle?
Arthritis
Micro RNAs 26b, 20a inversely correlate with GSK-3 ?/NF-?B/NLRP-3 pathway to highlight the additive promising effects of atorvastatin and quercetin in experimental induced arthritis.
Arthritis
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway.
Arthritis
Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes.
Arthritis
Sympathetic Nerve Hyperactivity in the Spleen: Causal for Nonpathogenic-Driven Chronic Immune-Mediated Inflammatory Diseases (IMIDs)?
Arthritis, Experimental
Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis.
Arthritis, Experimental
Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.
Arthritis, Experimental
Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis.
Arthritis, Experimental
Low dose IL-2 suppress osteoclastogenesis in collagen-induced arthritis via JNK dependent pathway.
Arthritis, Experimental
Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Arthritis, Experimental
[Effect of Xinfeng Capsule on Beclin1/PI3K-AKT-mTOR of Adjuvant Arthritis Rats].
Arthritis, Rheumatoid
Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis.
Arthritis, Rheumatoid
Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt.
Arthritis, Rheumatoid
Comparison of Serum Levels of 14-3-3 ETA Proteins between Rheumatoid Arthritis, Osteoarthritis and Normal Controls.
Arthritis, Rheumatoid
Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics: Two Examples of Rheumatoid Arthritis.
Arthritis, Rheumatoid
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.
Arthritis, Rheumatoid
Diagnostic accuracy of 14-3-3 ? protein in rheumatoid arthritis: A meta-analysis.
Arthritis, Rheumatoid
DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis.
Arthritis, Rheumatoid
Exploration of a binding mode of benzothiazol-2-yl acetonitrile pyrimidine core based derivatives as potent c-Jun N-terminal kinase-3 inhibitors and 3D-QSAR analyses.
Arthritis, Rheumatoid
Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.
Arthritis, Rheumatoid
GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1.
Arthritis, Rheumatoid
Impact of rheumatoid arthritis-associated HLA-DRbeta1 subtypes on protein kinase A signaling.
Arthritis, Rheumatoid
Inflammatory Diseases Among Norwegian LRRK2 Mutation Carriers. A 15-Years Follow-Up of a Cohort.
Arthritis, Rheumatoid
Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue.
Arthritis, Rheumatoid
Long non-coding RNA growth arrest-specific transcript 5 regulates rheumatoid arthritis by targeting homeodomain-interacting protein kinase 2.
Arthritis, Rheumatoid
MAST3 modulates the inflammatory response and proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
Arthritis, Rheumatoid
MicroRNA-27b-3p inhibits apoptosis of chondrocyte in rheumatoid arthritis by targeting HIPK2.
Arthritis, Rheumatoid
New BRAF (v raf murine sarcoma viral oncogene homologue B1) mutation in rheumatoid arthritis.
Arthritis, Rheumatoid
Pim-2/mTORC1 Pathway Shapes Inflammatory Capacity in Rheumatoid Arthritis Synovial Cells Exposed to Lipid Peroxidations.
Arthritis, Rheumatoid
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Arthritis, Rheumatoid
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Arthritis, Rheumatoid
Reduction of SR Ca(2+) leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability.
Arthritis, Rheumatoid
Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis.
Arthritis, Rheumatoid
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway.
Arthritis, Rheumatoid
Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.
Arthritis, Rheumatoid
Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Arthritis, Rheumatoid
Secreted frizzled-related protein 5 suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through down-regulation of c-Jun N-terminal kinase.
Arthritis, Rheumatoid
Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.
Arthritis, Rheumatoid
[Effect of rheumatoid arthritis associated HLA-DRbeta1 subtypes on protein kinase A signaling]
Ascorbic Acid Deficiency
Dietary vitamin C deficiency depressed the gill physical barriers and immune barriers referring to Nrf2, apoptosis, MLCK, NF-?B and TOR signaling in grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare.
Ascorbic Acid Deficiency
Dietary vitamin C deficiency depresses the growth, head kidney and spleen immunity and structural integrity by regulating NF-?B, TOR, Nrf2, apoptosis and MLCK signaling in young grass carp (Ctenopharyngodon idella).
Ascorbic Acid Deficiency
Vitamin C deficiency aggravates tumor necrosis factor ?-induced insulin resistance.
Asthenozoospermia
Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormality of the flagella.
Asthma
"Jnking" atherosclerosis.
Asthma
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.
Asthma
A selective small-molecule inhibitor of c-Jun N-terminal kinase 1.
Asthma
Allergic asthma: RIPK2 takes the lead.
Asthma
Anti-inflammatory potential of PI3K? and JAK inhibitors in asthma patients.
Asthma
Antisense- and RNA interference-based therapeutic strategies in allergy.
Asthma
CaMKII is essential for the proasthmatic effects of oxidation.
Asthma
CaMKII Oxidation Regulates Cockroach Allergen-Induced Mitophagy in Asthma.
Asthma
Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma.
Asthma
Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma.
Asthma
Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression.
Asthma
Ezrin Orchestrates Signal Transduction in Airway Cells.
Asthma
Glucocorticoid- and Protein Kinase A- dependent Transcriptome Regulation in Airway Smooth Muscle.
Asthma
Glycogen synthase kinase-3beta inhibition attenuates asthma in mice.
Asthma
Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3.
Asthma
IL-27 alleviates airway remodeling in a mouse model of asthma via PI3K/Akt pathway.
Asthma
Inhibition of Glycogen Synthase Kinase-3{beta} Is Sufficient for Airway Smooth Muscle Hypertrophy.
Asthma
Inhibition of p21-activated kinase 1 attenuates the cardinal features of asthma through suppressing the lymph node homing of dendritic cells.
Asthma
Interactive Roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases.
Asthma
Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma.
Asthma
N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression.
Asthma
NGF/TrkA-mediated Kidins220/ARMS signaling activated in the allergic airway challenge in mice.
Asthma
NOD1 sensing of house dust mite-derived microbiota promotes allergic experimental asthma.
Asthma
Oxidative CaMKII as a potential target for inflammatory disease (Review).
Asthma
Oxidized CaMKII promotes asthma through the activation of mast cells.
Asthma
Receptor Interacting Protein 2 (RIP2) Is Dispensable for OVA-Induced Airway Inflammation in Mice.
Asthma
Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients.
Asthma
Titanium dioxide particles modulate epithelial barrier protein, Claudin 7 in asthma.
Asthma
[Cross-talk between calcineurin and protein kinases in airway remodeling in asthma]
Asthma
[Expression of Rock2 and TGF-?1 mRNA and glucocorticoid intervention in asthmatic rats].
Asthma
[Regulation of acupuncture on expression of AKT protein in lung tissues of asthma rats].
Asthma
[Role of c-Jun N-terminal kinase signal transduction pathway in the course of airway remodeling of asthma rat]
Astrocytoma
14-3-3? regulates the proliferation of glioma cells through the GSK3?/?-catenin signaling pathway.
Astrocytoma
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
Astrocytoma
AQP9 promotes astrocytoma cell invasion and motility via the AKT pathway.
Astrocytoma
Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.
Astrocytoma
Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.
Astrocytoma
Differential Expression of the Tumor Suppressor A-Kinase Anchor Protein 12 in Human Diffuse and Pilocytic Astrocytomas Is Regulated by Promoter Methylation.
Astrocytoma
Down-regulation of 14-3-3 zeta sensitizes human glioblastoma cells to apoptosis induction.
Astrocytoma
Down-regulation of 14-3-3? exerts anti-cancer effects through inducing ER stress in human glioma U87 cells: Involvement of CHOP-Wnt pathway.
Astrocytoma
Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas.
Astrocytoma
Expression, association with clinicopathological features and prognostic potential of CEP55, p-Akt, FoxM1 and MMP-2 in astrocytoma.
Astrocytoma
High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.
Astrocytoma
Identification of 14-3-3 protein isoforms in human astrocytoma by immunohistochemistry.
Astrocytoma
IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK.
Astrocytoma
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Astrocytoma
Implication of 14-3-3? and 14-3-3?/? in proteasome inhibition-induced apoptosis of glioma cells.
Astrocytoma
Isoform-specific expression of 14-3-3 proteins in human astrocytoma.
Astrocytoma
Lensoside A? as an Adjuvant to the Anti-Glioma Potential of Sorafenib.
Astrocytoma
Methylation Patterns of DKK1, DKK3 and GSK3? Are Accompanied with Different Expression Levels in Human Astrocytoma.
Astrocytoma
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.
Astrocytoma
Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells.
Astrocytoma
Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells.
Astrocytoma
Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells.
Astrocytoma
Proteomic analysis of low- to high-grade astrocytomas reveals an alteration of the expression level of raf kinase inhibitor protein and nucleophosmin.
Astrocytoma
Rapamycin inhibits substance P-induced protein synthesis and phosphorylation of PHAS-I (4E-BP1) and p70 S6 kinase (p70(S6K)) in human astrocytoma cells.
Astrocytoma
Regulation of connexin 43 and microRNA expression via ?2-adrenoceptor signaling in 1321N1 astrocytoma cells.
Astrocytoma
Selective ?2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac.
Astrocytoma
The expression of seven 14-3-3 isoforms in human meningioma.
Astrocytoma
Up-regulation of protein l-isoaspartyl methyltransferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization.
Astrocytoma
[The stimulation of glutamate uptake by the phorbol ester in rat cerebral cortex synaptosomes and cell line of human anaplastic astrocytoma BT-325]
Asymptomatic Infections
14-3-3 Protein in CSF Reflects SIV-Mediated Pre-Synaptic Damage.
Asymptomatic Infections
14-3-3 protein in CSF: an early predictor of SIV CNS disease.
Ataxia
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation.
Ataxia
Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease.
Ataxia
Ataxia telangiectasia alters the ApoB and reelin pathway.
Ataxia
Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells.
Ataxia
Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.
Ataxia
Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein.
Ataxia
ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence?
Ataxia
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.
Ataxia
Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type 2.
Ataxia
Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage.
Ataxia
Diffusion-weighted MRI in Creutzfeldt-Jakob disease: a better diagnostic marker than CSF protein 14-3-3?
Ataxia
DNA double-strand breaks disrupted the spindle assembly in porcine oocytes.
Ataxia
DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).
Ataxia
DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals.
Ataxia
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.
Ataxia
Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine.
Ataxia
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Ataxia
Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells.
Ataxia
Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway.
Ataxia
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
Ataxia
Nuclear factor-like factor 2-antioxidant activation through the action of ataxia telangiectasia-mutated serine/threonine kinase is essential to counteract oxidative stress in bovine mammary epithelial cells.
Ataxia
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ataxia
Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18.
Ataxia
Tel2 regulates the stability of PI3K-related protein kinases.
Ataxia
The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations.
Ataxia
The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage.
Ataxia
The first Chinese case of Creutzfeldt-Jakob disease with mutation of E200K in PRNP.
Ataxia
The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.
Ataxia
The Mismatch-Binding Factor MutS? Can Mediate ATR Activation in Response to DNA Double-Strand Breaks.
Ataxia
Topoisomerase II?-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation.
Ataxia Telangiectasia
14th International Workshop on Ataxia-Telangiectasia ATW2012.
Ataxia Telangiectasia
2-Deoxy-D-glucose and ferulic acid modulates radiation response signaling in non-small cell lung cancer cells.
Ataxia Telangiectasia
24 targeted disruption of ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer.
Ataxia Telangiectasia
3F-Box protein 32 degrades ataxia telangiectasia and Rad3-related and regulates DNA damage response induced by gemcitabine in pancreatic cancer.
Ataxia Telangiectasia
4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway.
Ataxia Telangiectasia
5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.
Ataxia Telangiectasia
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
Ataxia Telangiectasia
53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response.
Ataxia Telangiectasia
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
Ataxia Telangiectasia
53BP1 facilitates long-range DNA end-joining during V(D)J recombination.
Ataxia Telangiectasia
53BP1 is limiting for nonhomologous end-joining in ATM-deficient cells subjected to oncogenic stress or radiation.
Ataxia Telangiectasia
53BP1 loss suppresses the radiosensitizing effect of icotinib hydrochloride in colorectal cancer cells.
Ataxia Telangiectasia
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.
Ataxia Telangiectasia
53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope.
Ataxia Telangiectasia
53BP1, an activator of ATM in response to DNA damage.
Ataxia Telangiectasia
7-hydroxy-staurosporine, UCN-01, induces DNA damage response, and autophagy in human osteosarcoma U2-OS cells.
Ataxia Telangiectasia
?-elemene enhances both radiosensitivity and chemosensitivity of glioblastoma cells through the inhibition of the ATM signaling pathway.
Ataxia Telangiectasia
?-H2AX and phosphorylated ATM focus formation in cancer cells after laser plasma X irradiation.
Ataxia Telangiectasia
?-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Ataxia Telangiectasia
?-Radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines.
Ataxia Telangiectasia
A 20-year perspective on the International Fanconi Anemia Registry (IFAR).
Ataxia Telangiectasia
A Case of Therapy-Related Acute Myeloid Leukemia in a Patient With Heterozygous Mutations in the Ataxia Telangiectasia Mutated Gene.
Ataxia Telangiectasia
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.
Ataxia Telangiectasia
A consensus set of genetic vulnerabilities to ATR inhibition.
Ataxia Telangiectasia
A coordinated DNA damage response promotes adult quiescent neural stem cell activation.
Ataxia Telangiectasia
A critical role for topoisomerase IIb and DNA double strand breaks in transcription.
Ataxia Telangiectasia
A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells.
Ataxia Telangiectasia
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-?B activation.
Ataxia Telangiectasia
A developmental role for ataxia-telangiectasia mutated in protecting the embryo from spontaneous and phenytoin-enhanced embryopathies in culture.
Ataxia Telangiectasia
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.
Ataxia Telangiectasia
A Dual Role of ATM in Ischemic Preconditioning and Ischemic Injury.
Ataxia Telangiectasia
A dynamic model for the p53 stress response networks under ion radiation.
Ataxia Telangiectasia
A functional link between SIRT1 deacetylase and NBS1 in DNA damage response.
Ataxia Telangiectasia
A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.
Ataxia Telangiectasia
A germline chromothripsis event stably segregating in 11 individuals through three generations.
Ataxia Telangiectasia
A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response.
Ataxia Telangiectasia
A hypomorphic mutation reveals a stringent requirement for the ATM checkpoint protein in telomere protection during early cell division in Drosophila.
Ataxia Telangiectasia
A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers.
Ataxia Telangiectasia
A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.
Ataxia Telangiectasia
A majority of human melanoma cell lines exhibits an s phase-specific defect in excision of UV-induced DNA photoproducts.
Ataxia Telangiectasia
A mathematical model of P53 gene regulatory networks under radiotherapy.
Ataxia Telangiectasia
A meta-analysis of the relationship between ataxia-telangiectasia mutated gene polymorphisms and lung cancer susceptibility.
Ataxia Telangiectasia
A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.
Ataxia Telangiectasia
A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation.
Ataxia Telangiectasia
A murine model of Nijmegen breakage syndrome.
Ataxia Telangiectasia
A Mutant Allele of MRE11 Found in Mismatch Repair-deficient Tumor Cells Suppresses the Cellular Response to DNA Replication Fork Stress in a Dominant Negative Manner.
Ataxia Telangiectasia
A new ataxia-telangiectasia mutation in an 11-year-old female.
Ataxia Telangiectasia
A novel 1-((3-(2-toluyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-(trifluoromethyl)pyrimidin-2(1H)-one activates intrinsic mitochondria-dependent pathway and decreases angiogenesis in PC-3 cells.
Ataxia Telangiectasia
A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks.
Ataxia Telangiectasia
A Novel Anticancer Agent, 8-Methoxypyrimido[4',5':4,5]thieno(2,3-b) Quinoline-4(3H)-One Induces Neuro 2a Neuroblastoma Cell Death through p53-Dependent, Caspase-Dependent and -Independent Apoptotic Pathways.
Ataxia Telangiectasia
A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells.
Ataxia Telangiectasia
A Novel ATM Pathogenic Variant in an Italian Woman with Gallbladder Cancer.
Ataxia Telangiectasia
A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.
Ataxia Telangiectasia
A novel ATM/TP53/p21-mediated checkpoint only activated by chronic ?-irradiation.
Ataxia Telangiectasia
A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication.
Ataxia Telangiectasia
A Novel Homozygous Variant of SETX Causes Ataxia with Oculomotor Apraxia Type 2.
Ataxia Telangiectasia
A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.
Ataxia Telangiectasia
A novel mathematical model of ATM/p53/NF- ?B pathways points to the importance of the DDR switch-off mechanisms.
Ataxia Telangiectasia
A novel morphometry system automatically assessing the growth and regeneration of intestinal organoids.
Ataxia Telangiectasia
A novel mutation in ATM gene in a Saudi female with ataxia telangiectasia.
Ataxia Telangiectasia
A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation.
Ataxia Telangiectasia
A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma.
Ataxia Telangiectasia
A novel pathogenic variant in an Iranian Ataxia telangiectasia family revealed by next-generation sequencing followed by in silico analysis.
Ataxia Telangiectasia
A Novel Splice Site Mutation of the ATM Gene Associated with Ataxia Telangiectasia.
Ataxia Telangiectasia
A pathway linking translation stress to checkpoint kinase 2 signaling in Neurospora crassa.
Ataxia Telangiectasia
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Ataxia Telangiectasia
A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4.
Ataxia Telangiectasia
A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
Ataxia Telangiectasia
A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation.
Ataxia Telangiectasia
A plausible model for the digital response of p53 to DNA damage.
Ataxia Telangiectasia
A polymorphism in the ATM gene modulates the penetrance of hereditary non-polyposis colorectal cancer.
Ataxia Telangiectasia
A radical view of pathological vasculature.
Ataxia Telangiectasia
A radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas.
Ataxia Telangiectasia
A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma.
Ataxia Telangiectasia
A role for AMPK in increased insulin action after serum starvation.
Ataxia Telangiectasia
A role for ataxia telangiectasia mutated in insulin-independent stimulation of glucose transport.
Ataxia Telangiectasia
A role for Xrcc2 in the early stages of mouse development.
Ataxia Telangiectasia
A Ser49Cys variant in the ataxia telangiectasia, mutated, gene that is more common in patients with breast carcinoma compared with population controls.
Ataxia Telangiectasia
A Soft Coral-Derived Compound, 11-Dehydrosinulariolide, Induces G2/M Cell Cycle Arrest and Apoptosis in Small Cell Lung Cancer.
Ataxia Telangiectasia
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome.
Ataxia Telangiectasia
A study of over 35,000 women with breast cancer tested with a 25-gene panel of hereditary cancer genes.
Ataxia Telangiectasia
A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma.
Ataxia Telangiectasia
A systematic review of the prevalence of DNA damage response gene mutations in prostate cancer.
Ataxia Telangiectasia
A TAD closer to ATM.
Ataxia Telangiectasia
A triskelion of nucleic acids drives protein aggregation in A-T.
Ataxia Telangiectasia
Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer.
Ataxia Telangiectasia
Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia.
Ataxia Telangiectasia
Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.
Ataxia Telangiectasia
Aberrant sensing of extracellular Ca2+ by cultured ataxia telangiectasia fibroblasts.
Ataxia Telangiectasia
Aberrant TCR? rearrangement underlies the T cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.
Ataxia Telangiectasia
Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining.
Ataxia Telangiectasia
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.
Ataxia Telangiectasia
Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.
Ataxia Telangiectasia
Abnormal expression of p-ATM/CHK2 in nasal extranodal NK/T cell lymphoma, nasal type, is correlated with poor prognosis.
Ataxia Telangiectasia
Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX.
Ataxia Telangiectasia
Absence of ATM deletions in 16 cases of splenic marginal-zone B-cell lymphoma (SMZBCL).
Ataxia Telangiectasia
Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice.
Ataxia Telangiectasia
Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer.
Ataxia Telangiectasia
Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.
Ataxia Telangiectasia
Accumulation of apoptosis-insensitive human bone marrow-mesenchymal stromal cells after long-term expansion.
Ataxia Telangiectasia
Acidic pH induces topoisomerase II-mediated DNA damage.
Ataxia Telangiectasia
Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression.
Ataxia Telangiectasia
Activation and Inhibition of ATM by Phytochemicals: Awakening and Sleeping the Guardian Angel Naturally.
Ataxia Telangiectasia
Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic.
Ataxia Telangiectasia
Activation of an ataxia telangiectasia mutation-dependent intra-S-phase checkpoint by anti-tumour drugs in HL-60 and human lymphoblastoid cells.
Ataxia Telangiectasia
Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks.
Ataxia Telangiectasia
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.
Ataxia Telangiectasia
Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies.
Ataxia Telangiectasia
Activation of ATM-c-IAP1 Pathway Mediates the Protective Effects of Estradiol in Human Vascular Endothelial Cells Exposed to Intermittent Hypoxia.
Ataxia Telangiectasia
Activation of ATM-Chk2 by 16-dehydropregnenolone induces G1 phase arrest and apoptosis in HeLa cells.
Ataxia Telangiectasia
Activation of ATM-dependent DNA Damage Signal Pathway by a Histone Deacetylase Inhibitor, Trichostatin A.
Ataxia Telangiectasia
Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus.
Ataxia Telangiectasia
Activation of DNA damage response signaling by condensed chromatin.
Ataxia Telangiectasia
Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.
Ataxia Telangiectasia
Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.
Ataxia Telangiectasia
Activation of interferon-stimulated genes by {gamma}-ray irradiation independently of the ataxia telangiectasia mutated-p53 pathway.
Ataxia Telangiectasia
Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation.
Ataxia Telangiectasia
Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease.
Ataxia Telangiectasia
Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis.
Ataxia Telangiectasia
Activation of the phosphorylation of ATM contributes to radioresistance of glioma stem cells.
Ataxia Telangiectasia
Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage.
Ataxia Telangiectasia
Activation of the S phase DNA damage checkpoint by mitomycin C.
Ataxia Telangiectasia
Acute Lymphoblastic Leukemia in Early Childhood as the Presenting Sign of Ataxia-Telangiectasia Variant.
Ataxia Telangiectasia
Acute Megakaryoblastic Leukemia with Myelodysplasia-related Changes Associated with ATM Gene Deletion.
Ataxia Telangiectasia
Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR-RAPTOR.
Ataxia Telangiectasia
Adaptive response and the influence of ageing: effects of low-dose irradiation on cell growth of cultured glial cells.
Ataxia Telangiectasia
Adefovir dipivoxil induces DNA replication stress and augments ATR inhibitor related cytotoxicity.
Ataxia Telangiectasia
Adenovirus-mediated wild-type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity.
Ataxia Telangiectasia
Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy.
Ataxia Telangiectasia
Aging of the Immune System. Mechanisms and Therapeutic Targets.
Ataxia Telangiectasia
Agrobacterium T-DNA integration into the plant genome can occur without the activity of key non-homologous end-joining proteins.
Ataxia Telangiectasia
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition.
Ataxia Telangiectasia
ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis.
Ataxia Telangiectasia
Allele and genotype frequency of a genetic variant in ataxia telangiectasia mutated gene affecting glycemic response to metformin in South Indian population.
Ataxia Telangiectasia
Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models.
Ataxia Telangiectasia
Allogeneic Stem Cell Transplantation after Fanconi Anemia Conditioning in Children with Ataxia-Telangiectasia Results in Stable T Cell Engraftment and Lack of Infections despite Mixed Chimerism.
Ataxia Telangiectasia
Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function.
Ataxia Telangiectasia
ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156.
Ataxia Telangiectasia
Alteration of the ATM gene occurs in gastric cancer cell lines and primary tumors associated with cellular response to DNA damage.
Ataxia Telangiectasia
Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin.
Ataxia Telangiectasia
Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma.
Ataxia Telangiectasia
Alterations of Nuclear Architecture and Epigenetic Signatures during African Swine Fever Virus Infection.
Ataxia Telangiectasia
Altered spectra of hypermutation in DNA repair-deficient mice.
Ataxia Telangiectasia
Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response.
Ataxia Telangiectasia
AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway.
Ataxia Telangiectasia
An Alu-derived intronic splicing enhancer facilitates intronic processing and modulates aberrant splicing in ATM.
Ataxia Telangiectasia
An ATM-independent S-phase checkpoint response involves CHK1 pathway.
Ataxia Telangiectasia
An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.
Ataxia Telangiectasia
An essential function for NBS1 in the prevention of ataxia and cerebellar defects.
Ataxia Telangiectasia
An Exploratory Study of Radiation Dermatitis in Breast Cancer Patients.
Ataxia Telangiectasia
An HTRF(®) Assay for the Protein Kinase ATM.
Ataxia Telangiectasia
An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.
Ataxia Telangiectasia
Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A - ATM - p53 signaling pathway.
Ataxia Telangiectasia
Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns.
Ataxia Telangiectasia
Analysis of Chromatin Opening in Heterochromatic Non-Small Cell Lung Cancer Tumor-Initiating Cells in Relation to DNA-Damaging Antitumor Treatment.
Ataxia Telangiectasia
Analysis of chromosomal aberrations and ?H2A.X foci to identify radiation-sensitive ataxia-telangiectasia patients.
Ataxia Telangiectasia
Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease.
Ataxia Telangiectasia
Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry.
Ataxia Telangiectasia
Analyzing ATM Function by Electroporation of Endonucleases and Immunofluorescence Microscopy.
Ataxia Telangiectasia
Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer.
Ataxia Telangiectasia
Analyzing the regulation and function of ATM.
Ataxia Telangiectasia
Antaxia-telangiectasia mutated gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers.
Ataxia Telangiectasia
Anthracyclines induce DNA damage response-mediated protection against severe sepsis.
Ataxia Telangiectasia
Anti-malarial atovaquone exhibits anti-tumor effects by inducing DNA damage in hepatocellular carcinoma.
Ataxia Telangiectasia
Anti-proliferative effect of isorhamnetin on HeLa cells through inducing G2/M cell cycle arrest.
Ataxia Telangiectasia
Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells.
Ataxia Telangiectasia
Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells.
Ataxia Telangiectasia
Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity.
Ataxia Telangiectasia
Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling.
Ataxia Telangiectasia
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis.
Ataxia Telangiectasia
Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells.
Ataxia Telangiectasia
Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk.
Ataxia Telangiectasia
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses.
Ataxia Telangiectasia
Apigenin restores impairment of autophagy and downregulation of unfolded protein response regulatory proteins in keratinocytes exposed to ultraviolet B radiation.
Ataxia Telangiectasia
Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress.
Ataxia Telangiectasia
APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM.
Ataxia Telangiectasia
Arabidopsis ATM and ATR kinases prevent propagation of genome damage caused by telomere dysfunction.
Ataxia Telangiectasia
Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway.
Ataxia Telangiectasia
Are DNA damage response kinases a target for the differentiation treatment of acute myeloid leukemia?
Ataxia Telangiectasia
Are polymorphisms of the ataxia telangiectasia mutated gene associated with breast cancer risk?
Ataxia Telangiectasia
Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?
Ataxia Telangiectasia
Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells.
Ataxia Telangiectasia
Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression.
Ataxia Telangiectasia
ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis.
Ataxia Telangiectasia
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
Ataxia Telangiectasia
Arsenite induces prominent mitotic arrest via inhibition of G2 checkpoint activation in CGL-2 cells.
Ataxia Telangiectasia
Artemis links ATM to double strand break rejoining.
Ataxia Telangiectasia
Artemis-dependent DNA double-strand break formation at stalled replication forks.
Ataxia Telangiectasia
Arterial "inflammaging" drives vascular calcification in children on dialysis.
Ataxia Telangiectasia
ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation.
Ataxia Telangiectasia
Assaying for Radioresistant DNA Synthesis, the Hallmark Feature of the Intra-S-Phase Checkpoint Using a DNA Fiber Technique.
Ataxia Telangiectasia
Assessment of the role of translationally controlled tumor protein 1 (TPT1/TCTP) in breast cancer susceptibility and ATM signaling.
Ataxia Telangiectasia
AsSIRTing the DNA damage response.
Ataxia Telangiectasia
Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.
Ataxia Telangiectasia
Association between a gene variant near ataxia telangiectasia mutated and coronary artery disease in men.
Ataxia Telangiectasia
Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females.
Ataxia Telangiectasia
Association between Ataxia Telangiectasia Mutated gene polymorphisms and childhood leukemia in Taiwan.
Ataxia Telangiectasia
Association between ATM gene polymorphisms, lung cancer susceptibility and radiation-induced pneumonitis: a meta-analysis.
Ataxia Telangiectasia
Association between ATM polymorphisms and cancer risk: a meta-analysis.
Ataxia Telangiectasia
Association between ATM rs1801516 polymorphism and cancer susceptibility: a meta-analysis involving 12,879 cases and 18,054 controls.
Ataxia Telangiectasia
Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility.
Ataxia Telangiectasia
Association between polymorphisms of the ataxia telangiectasia mutated gene and breast cancer risk: evidence from the current studies.
Ataxia Telangiectasia
Association between the rs189037 single nucleotide polymorphism in the ATM gene promoter and cognitive impairment.
Ataxia Telangiectasia
Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma.
Ataxia Telangiectasia
Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients.
Ataxia Telangiectasia
Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy.
Ataxia Telangiectasia
Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes.
Ataxia Telangiectasia
Association of the ATM gene polymorphisms with papillary thyroid cancer.
Ataxia Telangiectasia
Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non-Small Cell Lung Cancer.
Ataxia Telangiectasia
Associations of ATM Polymorphisms With Survival in Advanced Esophageal Squamous Cell Carcinoma Patients Receiving Radiation Therapy.
Ataxia Telangiectasia
Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand.
Ataxia Telangiectasia
Ataxia telangiectasia heterozygotes and patients display increased fluidity and decrease in contents of sulfhydryl groups in red blood cell membranes.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence.
Ataxia Telangiectasia
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.
Ataxia Telangiectasia
Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase Inhibition Is Synthetically Lethal in XRCC1 Deficient Ovarian Cancer Cells.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated coordinates the ovarian DNA repair and atresia-initiating response to phosphoramide mustard.
Ataxia Telangiectasia
Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity.
Ataxia Telangiectasia
Ataxia telangiectasia mutated deficiency does not result in genetic susceptibility to 50?Hz magnetic fields exposure in mouse embryonic fibroblasts.
Ataxia Telangiectasia
Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy.
Ataxia Telangiectasia
Ataxia telangiectasia mutated expression and activation in the testis.
Ataxia Telangiectasia
Ataxia telangiectasia mutated germline pathogenic variant in adrenocortical carcinoma.
Ataxia Telangiectasia
Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity.
Ataxia Telangiectasia
Ataxia telangiectasia mutated influences cytochrome c oxidase activity.
Ataxia Telangiectasia
Ataxia telangiectasia mutated inhibitor-loaded copper sulfide nanoparticles for low-temperature photothermal therapy of hepatocellular carcinoma.
Ataxia Telangiectasia
Ataxia telangiectasia mutated inhibits oxidative stress-induced apoptosis by regulating heme oxygenase-1 expression.
Ataxia Telangiectasia
Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Ataxia Telangiectasia
Ataxia telangiectasia mutated is essential during adult neurogenesis.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase controls chronic gammaherpesvirus infection.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase deficiency impairs the autophagic response early during myocardial infarction.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase in the heart: currency for myocyte apoptosis.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase is an autophagic balancer at the onset of heart failure.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Kinase Mediates NF-?B Serine 276 Phosphorylation and Interferon Expression via the IRF7-RIG-I Amplification Loop in Paramyxovirus Infection.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase plays a protective role in ?-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling.
Ataxia Telangiectasia
Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Protein Kinase: A Potential Master Puppeteer of Oxidative Stress-Induced Metabolic Recycling.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer.
Ataxia Telangiectasia
Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.
Ataxia Telangiectasia
Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage.
Ataxia Telangiectasia
Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.
Ataxia Telangiectasia
Ataxia telangiectasia syndrome: moonlighting ATM.
Ataxia Telangiectasia
Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage.
Ataxia Telangiectasia
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Ataxia Telangiectasia
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians.
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM) participates in the regulation of ionizing radiation-induced cell death via MAPK14 in lung cancer H1299 cells.
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated (ATM) Protein Signaling Participates in Development of Pulmonary Arterial Hypertension in Rats.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated and Rad3-related kinase (ATR) is activated by mild hypothermia in mammalian cells and subsequently activates p53.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated interactor regulates head and neck cancer metastasis via KRas expression.
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated kinase: a potential new target for suppressing inflammation in heart failure?
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated Kinase: Role in Myocardial Remodeling.
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer.
Ataxia Telangiectasia
Ataxia-Telangiectasia Presenting as Cerebral Palsy and Recurrent Wheezing: A Case Report.
Ataxia Telangiectasia
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor ? light chain enhancer of activated B cells (NF?B) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Ataxia Telangiectasia
Ataxia-Telangiectasia-Mutated Protein Expression as a Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary Glands.
Ataxia Telangiectasia
Ataxia-telangiectasia: A review of clinical features and molecular pathology.
Ataxia Telangiectasia
Ataxia-telangiectasia: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management.
Ataxia Telangiectasia
Ataxia-telangiectasia: future prospects.
Ataxia Telangiectasia
ATM (ataxia telangiectasia mutated): expanding roles in the DNA damage response and cellular homeostasis.
Ataxia Telangiectasia
ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.
Ataxia Telangiectasia
ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis.
Ataxia Telangiectasia
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
Ataxia Telangiectasia
ATM activation by oxidative stress.
Ataxia Telangiectasia
ATM activation in hypoxia - causes and consequences.
Ataxia Telangiectasia
ATM activation in the presence of oxidative stress.
Ataxia Telangiectasia
ATM activation is impaired in human cells defective in RecQL4 helicase activity.
Ataxia Telangiectasia
ATM acts downstream of ATR in the DNA damage response signaling of bystander cells.
Ataxia Telangiectasia
ATM and ATR Expression Potentiates HBV Replication and Contributes to Reactivation of HBV Infection upon DNA Damage.
Ataxia Telangiectasia
ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in Caenorhabditis elegans.
Ataxia Telangiectasia
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks.
Ataxia Telangiectasia
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.
Ataxia Telangiectasia
ATM and GLUT1-S490 phosphorylation regulate GLUT1 mediated transport in skeletal muscle.
Ataxia Telangiectasia
ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo.
Ataxia Telangiectasia
ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells.
Ataxia Telangiectasia
ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance.
Ataxia Telangiectasia
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Ataxia Telangiectasia
ATM as a target for novel radiosensitizers.
Ataxia Telangiectasia
ATM at the crossroads of reactive oxygen species and autophagy.
Ataxia Telangiectasia
ATM binds to beta-adaptin in cytoplasmic vesicles.
Ataxia Telangiectasia
ATM blocks tunicamycin-induced endoplasmic reticulum stress.
Ataxia Telangiectasia
ATM controls DNA repair and mitochondria transfer between neighboring cells.
Ataxia Telangiectasia
ATM couples replication stress and metabolic reprogramming during cellular senescence.
Ataxia Telangiectasia
ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy.
Ataxia Telangiectasia
ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.
Ataxia Telangiectasia
ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes.
Ataxia Telangiectasia
ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans.
Ataxia Telangiectasia
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
Ataxia Telangiectasia
ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition.
Ataxia Telangiectasia
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.
Ataxia Telangiectasia
ATM Expression as a Prognostic Marker in Patients With Advanced Biliary Tract Cancer Treated With First-line Gemcitabine and Platinum Chemotherapy.
Ataxia Telangiectasia
ATM expression is attenuated by promoter hypermethylation in human ovarian endometriotic stromal cells.
Ataxia Telangiectasia
ATM Expression Is Elevated in Established Radiation-Resistant Breast Cancer Cells and Improves DNA Repair Efficiency.
Ataxia Telangiectasia
ATM expression predicts Veliparib and Irinotecan sensitivity in gastric cancer by mediating P53 independent regulation of cell cycle and apoptosis.
Ataxia Telangiectasia
ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection.
Ataxia Telangiectasia
ATM functions at the peroxisome to induce pexophagy in response to ROS.
Ataxia Telangiectasia
ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances.
Ataxia Telangiectasia
ATM Gene Mutation Detection Techniques and Functional Analysis.
Ataxia Telangiectasia
ATM gene mutations in sporadic breast cancer patients from Brazil.
Ataxia Telangiectasia
ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs.
Ataxia Telangiectasia
ATM gene polymorphisms are associated with poor prognosis of non-small cell lung cancer receiving radiation therapy.
Ataxia Telangiectasia
Atm heterozygosity cooperates with loss of Brca1 to increase the severity of mammary gland cancer and reduce ductal branching.
Ataxia Telangiectasia
Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.
Ataxia Telangiectasia
ATM impacts IGF-1 signaling in skeletal muscle.
Ataxia Telangiectasia
ATM in DNA repair in cancer.
Ataxia Telangiectasia
ATM in oral carcinogenesis: association with clinicopathological features.
Ataxia Telangiectasia
ATM Increases Activation-Induced Cytidine Deaminase Activity at Downstream S Regions during Class-Switch Recombination.
Ataxia Telangiectasia
ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines.
Ataxia Telangiectasia
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation.
Ataxia Telangiectasia
ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest.
Ataxia Telangiectasia
ATM inhibition prevents interleukin-6 from contributing to the proliferation of glioblastoma cells after ionizing radiation.
Ataxia Telangiectasia
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells.
Ataxia Telangiectasia
ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells.
Ataxia Telangiectasia
ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase ? Deficiency-Dependent Manner.
Ataxia Telangiectasia
ATM is a key driver of NF-?B-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Ataxia Telangiectasia
ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism.
Ataxia Telangiectasia
ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells.
Ataxia Telangiectasia
ATM is down-regulated by N-Myc-regulated microRNA-421.
Ataxia Telangiectasia
ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation.
Ataxia Telangiectasia
ATM is required for efficient recombination between immunoglobulin switch regions.
Ataxia Telangiectasia
ATM is required for the cellular response to thymidine induced replication fork stress.
Ataxia Telangiectasia
ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage.
Ataxia Telangiectasia
ATM is required for the repair of Topotecan-induced replication-associated double-strand breaks.
Ataxia Telangiectasia
ATM kinase activity is regulated by ATP-driven conformational changes in the MRN complex.
Ataxia Telangiectasia
ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis.
Ataxia Telangiectasia
ATM kinase activity modulates ITCH E3-ubiquitin ligase activity.
Ataxia Telangiectasia
ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.
Ataxia Telangiectasia
ATM kinase is activated by sindbis viral vector infection.
Ataxia Telangiectasia
ATM kinase regulates tumor immunoreactions in lymphocyte-predominant breast cancer through modulation of NKG2D ligand and TNF cytokines on tumor cells.
Ataxia Telangiectasia
ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy.
Ataxia Telangiectasia
ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence?
Ataxia Telangiectasia
ATM localization and gene expression in the adult mouse eye.
Ataxia Telangiectasia
ATM may be a protective factor in endometrial carcinogenesis with the progesterone pathway.
Ataxia Telangiectasia
ATM mediated-p53 signaling pathway forms a novel axis for senescence control.
Ataxia Telangiectasia
ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia.
Ataxia Telangiectasia
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Ataxia Telangiectasia
ATM mediates repression of DNA end-degradation in an ATP-dependent manner.
Ataxia Telangiectasia
ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot.
Ataxia Telangiectasia
ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response.
Ataxia Telangiectasia
ATM mutations as an independent prognostic factor and potential biomarker for immune checkpoint therapy in endometrial cancer.
Ataxia Telangiectasia
ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment.
Ataxia Telangiectasia
ATM mutations for surgeons.
Ataxia Telangiectasia
ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data.
Ataxia Telangiectasia
ATM Mutations in Cancer: Therapeutic Implications.
Ataxia Telangiectasia
ATM mutations in patients with hereditary pancreatic cancer.
Ataxia Telangiectasia
ATM mutations in sporadic lymphoid tumours.
Ataxia Telangiectasia
ATM mutations on distinct SNP and STR haplotypes in ataxia-telangiectasia patients of differing ethnicities reveal ancestral founder effects.
Ataxia Telangiectasia
ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming.
Ataxia Telangiectasia
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.
Ataxia Telangiectasia
ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
Ataxia Telangiectasia
ATM polymorphisms and risk of lung cancer among never smokers.
Ataxia Telangiectasia
ATM Polymorphisms Are Associated With Risk of Radiation-Induced Pneumonitis.
Ataxia Telangiectasia
ATM Polymorphisms Predict Severe Radiation Pneumonitis in Patients With Non-Small Cell Lung Cancer Treated With Definitive Radiation Therapy.
Ataxia Telangiectasia
ATM prevents DSB formation by coordinating SSB repair and cell cycle progression.
Ataxia Telangiectasia
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.
Ataxia Telangiectasia
ATM Prevents Unattended DNA Double Strand Breaks on Site and in Generations to Come.
Ataxia Telangiectasia
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Ataxia Telangiectasia
ATM Promotes RAD51-Mediated Meiotic DSB Repair by Inter-Sister-Chromatid Recombination in Arabidopsis.
Ataxia Telangiectasia
ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease.
Ataxia Telangiectasia
ATM Protein Kinase: Old and New Implications in Neuronal Pathways and Brain Circuitry.
Ataxia Telangiectasia
ATM protein overexpression in prostate tumors: possible role in telomere maintenance.
Ataxia Telangiectasia
ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
Ataxia Telangiectasia
ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.
Ataxia Telangiectasia
ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.
Ataxia Telangiectasia
ATM regulates a RASSF1A-dependent DNA damage response.
Ataxia Telangiectasia
ATM regulates ATR chromatin loading in response to DNA double-strand breaks.
Ataxia Telangiectasia
ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication.
Ataxia Telangiectasia
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.
Ataxia Telangiectasia
ATM regulates NF-?B-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment.
Ataxia Telangiectasia
ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance.
Ataxia Telangiectasia
ATM regulates the length of individual telomere tracts in Arabidopsis.
Ataxia Telangiectasia
ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion.
Ataxia Telangiectasia
ATM rs189037 (G?>?A) polymorphism increased the risk of cancer: an updated meta-analysis.
Ataxia Telangiectasia
ATM rs189037 (G > A) polymorphism and risk of lung cancer and head and neck cancer: A meta-analysis.
Ataxia Telangiectasia
ATM rs189037 significantly increases the risk of cancer in non-smokers rather than smokers: an updated meta-analysis.
Ataxia Telangiectasia
ATM Serine/Threonine Kinase and its Role in Pancreatic Risk.
Ataxia Telangiectasia
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
Ataxia Telangiectasia
ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells.
Ataxia Telangiectasia
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
Ataxia Telangiectasia
ATM supports gammaherpesvirus replication by attenuating type I interferon pathway.
Ataxia Telangiectasia
ATM Suppresses Leaf Senescence Triggered by DNA Double-strand Break through Epigenetic Control of Senescence-Associated Genes in Arabidopsis.
Ataxia Telangiectasia
ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations.
Ataxia Telangiectasia
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.
Ataxia Telangiectasia
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.
Ataxia Telangiectasia
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
Ataxia Telangiectasia
ATM, radiation, and the risk of second primary breast cancer.
Ataxia Telangiectasia
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.
Ataxia Telangiectasia
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks.
Ataxia Telangiectasia
ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?
Ataxia Telangiectasia
ATM-associated signalling triggers the unfolded protein response and cell death in response to stress.
Ataxia Telangiectasia
ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress.
Ataxia Telangiectasia
ATM-Deficient Cancers Provide New Opportunities for Precision Oncology.
Ataxia Telangiectasia
ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib.
Ataxia Telangiectasia
Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.
Ataxia Telangiectasia
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
Ataxia Telangiectasia
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins.
Ataxia Telangiectasia
ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition.
Ataxia Telangiectasia
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.
Ataxia Telangiectasia
ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.
Ataxia Telangiectasia
ATM-dependent cellular response to DNA double strand breaks plays a pivotal role in the maintenance of the integrity of the genome.
Ataxia Telangiectasia
ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia.
Ataxia Telangiectasia
ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response.
Ataxia Telangiectasia
ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions.
Ataxia Telangiectasia
ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin.
Ataxia Telangiectasia
ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses.
Ataxia Telangiectasia
ATM-Dependent Phosphorylation of MEF2D Promotes Neuronal Survival after DNA Damage.
Ataxia Telangiectasia
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
Ataxia Telangiectasia
ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
Ataxia Telangiectasia
ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response.
Ataxia Telangiectasia
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition.
Ataxia Telangiectasia
ATM-mediated KDM2A phosphorylation is required for the DNA damage repair.
Ataxia Telangiectasia
ATM-Mediated Mitochondrial Radiation Responses of Human Fibroblasts.
Ataxia Telangiectasia
ATM-mediated phosphorylation activates the tumor-suppressive function of B56?-PP2A.
Ataxia Telangiectasia
ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion.
Ataxia Telangiectasia
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.
Ataxia Telangiectasia
ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis.
Ataxia Telangiectasia
ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair.
Ataxia Telangiectasia
ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage.
Ataxia Telangiectasia
ATM-mediated transcriptional elevation of prion in response to copper-induced oxidative stress.
Ataxia Telangiectasia
ATM: the product of the gene mutated in ataxia-telangiectasia.
Ataxia Telangiectasia
ATM?JAK?PD?L1 signaling pathway inhibition decreases EMT and metastasis of androgen?independent prostate cancer.
Ataxia Telangiectasia
ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer.
Ataxia Telangiectasia
AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis.
Ataxia Telangiectasia
ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation.
Ataxia Telangiectasia
ATP synthase: an identified target gene of bantam in paired female Schistosoma japonicum.
Ataxia Telangiectasia
ATR alterations in Hodgkin's lymphoma.
Ataxia Telangiectasia
ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.
Ataxia Telangiectasia
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
Ataxia Telangiectasia
ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms.
Ataxia Telangiectasia
ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage.
Ataxia Telangiectasia
ATR regulates hexavalent chromium-induced S-phase checkpoint through phosphorylation of SMC1.
Ataxia Telangiectasia
ATR-Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine.
Ataxia Telangiectasia
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.
Ataxia Telangiectasia
ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells.
Ataxia Telangiectasia
ATR-mediated phosphorylation of DNA polymerase ? is needed for efficient recovery from UV damage.
Ataxia Telangiectasia
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
Ataxia Telangiectasia
ATR: an essential regulator of genome integrity.
Ataxia Telangiectasia
Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration.
Ataxia Telangiectasia
Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo.
Ataxia Telangiectasia
Attenuation of the oxidative burst-induced DNA damage in human leukocytes by hyaluronan.
Ataxia Telangiectasia
Autocrine regulation of ?-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors.
Ataxia Telangiectasia
Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells.
Ataxia Telangiectasia
Autophosphorylated residues involved in the regulation of human chk2 in vitro.
Ataxia Telangiectasia
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
Ataxia Telangiectasia
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Ataxia Telangiectasia
Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation.
Ataxia Telangiectasia
AZ32 Reverses ABCG2-Mediated Multidrug Resistance in Colorectal Cancer.
Ataxia Telangiectasia
B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection.
Ataxia Telangiectasia
Bacterial quorum-sensing signal IQS induces host cell apoptosis by targeting POT1-p53 signalling pathway.
Ataxia Telangiectasia
Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.
Ataxia Telangiectasia
Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes.
Ataxia Telangiectasia
Benzyl butyl phthalate (BBP) triggers the migration and invasion of hemangioma cells via upregulation of Zeb1.
Ataxia Telangiectasia
Beta Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes.
Ataxia Telangiectasia
Beta-Ecdysone Protects Mouse Osteoblasts from Glucocorticoid-Induced Apoptosis In Vitro.
Ataxia Telangiectasia
Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma.
Ataxia Telangiectasia
Beyond Kinases: Targeting Replication Stress Proteins in Cancer Therapy.
Ataxia Telangiectasia
Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism.
Ataxia Telangiectasia
Biallelic mutations in the ATM gene in T-prolymphocytic leukemia.
Ataxia Telangiectasia
Bifunctional DNA Alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea Activates the ATR-Chk1 Pathway Independently of the Mismatch Repair Pathway.
Ataxia Telangiectasia
Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2.
Ataxia Telangiectasia
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells.
Ataxia Telangiectasia
Bioinformatics Based Therapeutic Effects of Sinomenium Acutum.
Ataxia Telangiectasia
Biomarker-Guided Development of DNA Repair Inhibitors.
Ataxia Telangiectasia
BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients.
Ataxia Telangiectasia
Bisphenol A-Induced Ovotoxicity Involves DNA Damage Induction to Which the Ovary Mounts a Protective Response Indicated by Increased Expression of Proteins Involved in DNA Repair and Xenobiotic Biotransformation.
Ataxia Telangiectasia
Blm-s, a BH3-only protein enriched in postmitotic immature neurons, is transcriptionally upregulated by p53 during DNA damage.
Ataxia Telangiectasia
Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling.
Ataxia Telangiectasia
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Ataxia Telangiectasia
Bmi1 Augments Proliferation and Survival of Cortical Bone-Derived Stem Cells after Injury through Novel Epigenetic Signaling via Histone 3 Regulation.
Ataxia Telangiectasia
Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells.
Ataxia Telangiectasia
Bone marrow transplantation restores immune system function and prevents lymphoma in Atm-deficient mice.
Ataxia Telangiectasia
Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1.
Ataxia Telangiectasia
Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation.
Ataxia Telangiectasia
Brain and induced pluripotent stem cell-derived neural stem cells as an in vitro model of neurodegeneration in ataxia-telangiectasia.
Ataxia Telangiectasia
Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study.
Ataxia Telangiectasia
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging.
Ataxia Telangiectasia
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis.
Ataxia Telangiectasia
Brd4 Shields Chromatin from ATM Kinase Signaling Storms.
Ataxia Telangiectasia
Breaking the DNA damage response via serine/threonine kinase inhibitors to improve cancer treatment.
Ataxia Telangiectasia
Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.
Ataxia Telangiectasia
Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM.
Ataxia Telangiectasia
Buried territories: heterochromatic response to DNA double-strand breaks.
Ataxia Telangiectasia
c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP.
Ataxia Telangiectasia
c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF.
Ataxia Telangiectasia
c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance.
Ataxia Telangiectasia
Cadmium-induced adaptive response in cells of Chinese hamster ovary cell lines with varying DNA repair capacity.
Ataxia Telangiectasia
Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe.
Ataxia Telangiectasia
Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes.
Ataxia Telangiectasia
Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis.
Ataxia Telangiectasia
cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cells.
Ataxia Telangiectasia
Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells.
Ataxia Telangiectasia
Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro.
Ataxia Telangiectasia
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.
Ataxia Telangiectasia
Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells.
Ataxia Telangiectasia
Cardioprotective Function of Green Rooibos (Aspalathus linearis) Extract Supplementation in Ex Vivo Ischemic Prediabetic Rat Hearts.
Ataxia Telangiectasia
Caspase-3 knockout attenuates radiation-induced tumor repopulation via impairing the ATM/p53/Cox-2/PGE2 pathway in non-small cell lung cancer.
Ataxia Telangiectasia
CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth
Ataxia Telangiectasia
Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.
Ataxia Telangiectasia
CDK2 Is Required for the DNA Damage Response During Porcine Early Embryonic Development.
Ataxia Telangiectasia
CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.
Ataxia Telangiectasia
CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair.
Ataxia Telangiectasia
Cell cycle activation linked to neuronal cell death initiated by DNA damage.
Ataxia Telangiectasia
Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression.
Ataxia Telangiectasia
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.
Ataxia Telangiectasia
Cell cycle control, checkpoint mechanisms, and genotoxic stress.
Ataxia Telangiectasia
Cell fate decision mediated by p53 pulses.
Ataxia Telangiectasia
Cell synchronization by inhibitors of DNA replication induces replication stress and DNA damage response: analysis by flow cytometry.
Ataxia Telangiectasia
Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer.
Ataxia Telangiectasia
Cellular cytokine receptor signaling and ATM pathway intersections affect hepatic DNA repair.
Ataxia Telangiectasia
Cellular functions of the protein kinase ATM and their relevance to human disease.
Ataxia Telangiectasia
Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracil.
Ataxia Telangiectasia
Cellular senescence in aging primates.
Ataxia Telangiectasia
CENPO expression regulates gastric cancer cell proliferation and is associated with poor patient prognosis.
Ataxia Telangiectasia
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.
Ataxia Telangiectasia
Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study.
Ataxia Telangiectasia
Cerebral Abnormalities in Adults with Ataxia-Telangiectasia.
Ataxia Telangiectasia
Cervical malignant mixed mesonephric tumour: A case report with local recurrence after six-years and next-generation sequencing analysis with particular reference to the ataxia telangiectasia mutated gene.
Ataxia Telangiectasia
Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells.
Ataxia Telangiectasia
Challenges in implementing model-based phase I designs in a grant-funded clinical trials unit.
Ataxia Telangiectasia
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks.
Ataxia Telangiectasia
Changes in splicing factor expression are associated with advancing age in man.
Ataxia Telangiectasia
Characterisation of ATM Mutations in Slavic Ataxia Telangiectasia Patients.
Ataxia Telangiectasia
Characterization of an NBS1 C-terminal peptide that can inhibit ataxia telangiectasia mutated (ATM)-mediated DNA damage responses and enhance radiosensitivity.
Ataxia Telangiectasia
Characterization of Glioma Stem Cells Through Multiple Stem Cell Markers and Their Specific Sensitization to Double-Strand Break-Inducing Agents by Pharmacological Inhibition of Ataxia Telangiectasia Mutated Protein.
Ataxia Telangiectasia
Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability.
Ataxia Telangiectasia
Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression.
Ataxia Telangiectasia
Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer.
Ataxia Telangiectasia
Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism.
Ataxia Telangiectasia
Chemical inhibition of DNA repair kinases as a promising tool in oncology.
Ataxia Telangiectasia
Chemical screening identifies ATM as a target for alleviating senescence.
Ataxia Telangiectasia
Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines.
Ataxia Telangiectasia
Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction.
Ataxia Telangiectasia
Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways.
Ataxia Telangiectasia
Chk'ing p53-deficient breast cancers.
Ataxia Telangiectasia
CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Ataxia Telangiectasia
Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A.
Ataxia Telangiectasia
CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.
Ataxia Telangiectasia
Chk2 activation dependence on Nbs1 after DNA damage.
Ataxia Telangiectasia
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Ataxia Telangiectasia
CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).
Ataxia Telangiectasia
Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling.
Ataxia Telangiectasia
Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells.
Ataxia Telangiectasia
Chloroquine Improves Survival and Hematopoietic Recovery After Lethal Low-Dose-Rate Radiation.
Ataxia Telangiectasia
Chloroquine increases phosphorylation of AMPK and Akt in myotubes.
Ataxia Telangiectasia
Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells.
Ataxia Telangiectasia
Chromatin modifying protein 1A (Chmp1A) of the endosomal sorting complex required for transport (ESCRT)-III family activates ataxia telangiectasia mutated (ATM) for PanC-1 cell growth inhibition.
Ataxia Telangiectasia
Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest.
Ataxia Telangiectasia
Chromosomal instability at common fragile sites in Seckel syndrome.
Ataxia Telangiectasia
Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability.
Ataxia Telangiectasia
Chronic hypoxia in Andeans; are there lessons for neurology at sea level?
Ataxia Telangiectasia
Chronic lymphocytic leukemia-associated chromosomal abnormalities and miRNA deregulation.
Ataxia Telangiectasia
Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.
Ataxia Telangiectasia
Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation.
Ataxia Telangiectasia
Circadian proteins in the regulation of cell cycle and genotoxic stress responses.
Ataxia Telangiectasia
Circadian rhythm genes in cancer: insight into their functions and regulation involving noncoding RNAs.
Ataxia Telangiectasia
CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract.
Ataxia Telangiectasia
Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest.
Ataxia Telangiectasia
Cisplatinum and taxol induce different patterns of p53 phosphorylation.
Ataxia Telangiectasia
Claspin promotes normal replication fork rates in human cells.
Ataxia Telangiectasia
CLASS SWITCH RECOMBINATION PROCESS IN ATAXIA TELANGIECTASIA PATIENTS WITH ELEVATED SERUM LEVELS OF IgM.
Ataxia Telangiectasia
Classical ataxia telangiectasia patients have a congenitally aged immune system with high expression of CD95.
Ataxia Telangiectasia
Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation.
Ataxia Telangiectasia
Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.
Ataxia Telangiectasia
Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.
Ataxia Telangiectasia
Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK.
Ataxia Telangiectasia
Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth.
Ataxia Telangiectasia
Co-inhibition of Pol ? and ATR sensitizes cisplatin-resistant non-small cell lung cancer cells to cisplatin by impeding DNA damage repair.
Ataxia Telangiectasia
Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells.
Ataxia Telangiectasia
Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer.
Ataxia Telangiectasia
Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair.
Ataxia Telangiectasia
Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome.
Ataxia Telangiectasia
Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma.
Ataxia Telangiectasia
Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia.
Ataxia Telangiectasia
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells.
Ataxia Telangiectasia
Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells.
Ataxia Telangiectasia
Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.
Ataxia Telangiectasia
Common genetic changes in leiomyosarcoma and gastrointestinal stromal tumour: implication for ataxia telangiectasia mutated involvement.
Ataxia Telangiectasia
Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population.
Ataxia Telangiectasia
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
Ataxia Telangiectasia
Comparative toxicological evaluation of nonylphenol and nonylphenol polyethoxylates using human keratinocytes.
Ataxia Telangiectasia
Comparison of ataxia-telangiectasia mutated protein expression in diffuse large B-cell lymphomas of primary central nervous system and non-central nervous system origin.
Ataxia Telangiectasia
Compartmentalization of DNA Damage Response between Heterochromatin and Euchromatin Is Mediated by Distinct H2A Histone Variants.
Ataxia Telangiectasia
Competition between NBS1 and ATMIN controls ATM signaling pathway choice.
Ataxia Telangiectasia
Complementary functions of ATM and H2AX in development and suppression of genomic instability.
Ataxia Telangiectasia
Complete Pathologic Response of Multiple Liver Metastases and Clinical Complete Response of Rectal Cancer in a Patient with Ataxia-Telangiectasia Mutated Gene Mutations After XELOXIRI Plus Bevacizumab: A Case Report.
Ataxia Telangiectasia
Complete sequencing of full-length canine ataxia telangiectasia mutated mRNA and characterization of its putative promoter.
Ataxia Telangiectasia
Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.
Ataxia Telangiectasia
Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy.
Ataxia Telangiectasia
Concurrent TP53 and CDKN2A Gene Aberrations in Newly Diagnosed Mantle Cell Lymphoma Correlate with Chemoresistance and Call for Innovative Upfront Therapy.
Ataxia Telangiectasia
Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes.
Ataxia Telangiectasia
Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass.
Ataxia Telangiectasia
Confirmation that variants in TTI2 are responsible for autosomal recessive intellectual disability.
Ataxia Telangiectasia
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Ataxia Telangiectasia
Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
Ataxia Telangiectasia
Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity.
Ataxia Telangiectasia
Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency.
Ataxia Telangiectasia
Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection.
Ataxia Telangiectasia
Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma.
Ataxia Telangiectasia
Cooperative Enhancement of Radiosensitivity After Combined Treatment of 17-(Allylamino)-17-Demethoxygeldanamycin and Celecoxib in Human Lung and Colon Cancer Cell Lines.
Ataxia Telangiectasia
Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages.
Ataxia Telangiectasia
Coordinate to guard: crosstalk of phosphorylation, sumoylation, and ubiquitylation in DNA damage response.
Ataxia Telangiectasia
Cordycepin, isolated from medicinal fungus Cordyceps sinensis, enhances radiosensitivity of oral cancer associated with modulation of DNA damage repair.
Ataxia Telangiectasia
Correction of prototypic ATM splicing mutations and aberrant ATM function with antisense morpholino oligonucleotides.
Ataxia Telangiectasia
Correction to Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
Ataxia Telangiectasia
Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia.
Ataxia Telangiectasia
Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response.
Ataxia Telangiectasia
Cross talk between stimulated NF-kappaB and the tumor suppressor p53.
Ataxia Telangiectasia
Cross-species identification of in silico microsatellite biomarkers for genetic disease.
Ataxia Telangiectasia
Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations.
Ataxia Telangiectasia
Cryptic deletion involving the ATM locus at 11q22.3 approximately q23.1 in B-cell chronic lymphocytic leukemia and related disorders.
Ataxia Telangiectasia
CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response.
Ataxia Telangiectasia
CTCF prevents genomic instability by promoting homologous recombination-directed DNA double-strand break repair.
Ataxia Telangiectasia
Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner.
Ataxia Telangiectasia
Cutaneous Granulomatosis and Class Switching Defect as a Presenting Sign in Ataxia-Telangiectasia: First Case from the National Iranian Registry and Review of the Literature.
Ataxia Telangiectasia
Cutaneous granulomatosis and combined immunodeficiency revealing Ataxia-Telangiectasia: a case report.
Ataxia Telangiectasia
Cyclooxygenase?2?mediated upregulation of heme oxygenase 1 mitigates the toxicity of deuterium?tritium fusion radiation.
Ataxia Telangiectasia
Cyto-/genotoxic effect of CdSe/ZnS quantum dots in human lung adenocarcinoma cells for potential photodynamic UV therapy applications.
Ataxia Telangiectasia
Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents.
Ataxia Telangiectasia
Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation.
Ataxia Telangiectasia
Cytosine arabinoside induces phosphorylation of histone H2AX in hippocampal neurons via a noncanonical pathway.
Ataxia Telangiectasia
Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III.
Ataxia Telangiectasia
Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent.
Ataxia Telangiectasia
Damage-induced phosphorylation of Sld3 is important to block late origin firing.
Ataxia Telangiectasia
Danthron Induces DNA Damage and Inhibits DNA Repair Gene Expressions in GBM 8401 Human Brain Glioblastoma Multiforms Cells.
Ataxia Telangiectasia
Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
Ataxia Telangiectasia
DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression.
Ataxia Telangiectasia
Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish.
Ataxia Telangiectasia
Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.
Ataxia Telangiectasia
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.
Ataxia Telangiectasia
Decrease of Nibrin expression in chronic hypoxia is associated with hypoxia-induced chemoresistance in some brain tumour cells.
Ataxia Telangiectasia
Decreased activation of ataxia telangiectasia mutated (ATM) in monocytes?from patients with systemic sclerosis.
Ataxia Telangiectasia
Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease.
Ataxia Telangiectasia
Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB.
Ataxia Telangiectasia
Defective chromatin recruitment and retention of NHEJ core components in human tumor cells expressing a Cyclin E fragment.
Ataxia Telangiectasia
Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice.
Ataxia Telangiectasia
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Ataxia Telangiectasia
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.
Ataxia Telangiectasia
Defective p53 Response and Apoptosis Associated with an Ataxia-Telangiectasia-like Phenotype.
Ataxia Telangiectasia
Defective regulation of Ca2+/calmodulin-dependent protein kinase II in gamma-irradiated ataxia telangiectasia fibroblasts.
Ataxia Telangiectasia
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.
Ataxia Telangiectasia
Deficiency in the response to DNA double-strand breaks in mouse early preimplantation embryos.
Ataxia Telangiectasia
Deficiency of ataxia telangiectasia mutated kinase delays inflammatory response in the heart following myocardial infarction.
Ataxia Telangiectasia
Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis.
Ataxia Telangiectasia
Deficiency of ataxia-telangiectasia mutated kinase modulates functional and biochemical parameters of the heart in response to Western-type diet.
Ataxia Telangiectasia
Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
Ataxia Telangiectasia
Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals.
Ataxia Telangiectasia
Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma.
Ataxia Telangiectasia
Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity.
Ataxia Telangiectasia
Deletion of the B-B' and C-C' regions of inverted terminal repeats reduces rAAV productivity but increases transgene expression.
Ataxia Telangiectasia
Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation.
Ataxia Telangiectasia
Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance.
Ataxia Telangiectasia
Deoxypodophyllotoxin induces G(2)/M cell cycle arrest and apoptosis in HeLa cells.
Ataxia Telangiectasia
Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.
Ataxia Telangiectasia
Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation.
Ataxia Telangiectasia
Design and synthesis of pyrrolobenzodiazepine-gallic hybrid agents as p53-dependent and -independent apoptogenic signaling in melanoma cells.
Ataxia Telangiectasia
Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses.
Ataxia Telangiectasia
Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.
Ataxia Telangiectasia
Detecting ATM-dependent chromatin modification in DNA damage response.
Ataxia Telangiectasia
Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay.
Ataxia Telangiectasia
Detection of early abl kinase activation after ionizing radiation by using a Peptide biosensor.
Ataxia Telangiectasia
Determination of cell fate by c-Abl activation in the response to DNA damage.
Ataxia Telangiectasia
Development of a high-content high-throughput screening assay for the discovery of ATM signaling inhibitors.
Ataxia Telangiectasia
Development of an Immunohistochemical Assay to Detect the Ataxia-Telangiectasia Mutated (ATM) Protein in Gastric Carcinoma.
Ataxia Telangiectasia
Dichlorvos-induced cell cycle arrest and DNA damage repair activation in primary rat microglial cells.
Ataxia Telangiectasia
Dietary NiCl? causes G?/M cell cycle arrest in the broiler's kidney.
Ataxia Telangiectasia
Differences in the Response to DNA Double-Strand Breaks between Rod Photoreceptors of Rodents, Pigs, and Humans.
Ataxia Telangiectasia
Differential DNA damage responses in p53 proficient and deficient cells: cisplatin-induced nuclear import of XPA is independent of ATR checkpoint in p53-deficient lung cancer cells.
Ataxia Telangiectasia
Differential Expression of Small Heat Shock Protein 27 (Hsp27) in Ataxia telangiectasia Brains.
Ataxia Telangiectasia
Differential gene expression profile of retinoblastoma compared to normal retina.
Ataxia Telangiectasia
Differential Gene Expression Profiles of PPP2R5C-siRNA-Treated Malignant T Cells.
Ataxia Telangiectasia
Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.
Ataxia Telangiectasia
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Ataxia Telangiectasia
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.
Ataxia Telangiectasia
Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity.
Ataxia Telangiectasia
Differential responses to high- and low-dose ultraviolet-B stress in tobacco Bright Yellow-2 cells.
Ataxia Telangiectasia
Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.
Ataxia Telangiectasia
Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation.
Ataxia Telangiectasia
Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo.
Ataxia Telangiectasia
DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism.
Ataxia Telangiectasia
Direct activation of ATM by resveratrol under oxidizing conditions.
Ataxia Telangiectasia
Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.
Ataxia Telangiectasia
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.
Ataxia Telangiectasia
Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
Ataxia Telangiectasia
Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents.
Ataxia Telangiectasia
Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.
Ataxia Telangiectasia
Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions.
Ataxia Telangiectasia
Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression.
Ataxia Telangiectasia
Distinct biological effects of low-dose radiation on normal and cancerous human lung cells are mediated by ATM signaling.
Ataxia Telangiectasia
Distinct cellular responses to replication stress leading to apoptosis or senescence.
Ataxia Telangiectasia
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
Ataxia Telangiectasia
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.
Ataxia Telangiectasia
Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.
Ataxia Telangiectasia
Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.
Ataxia Telangiectasia
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.
Ataxia Telangiectasia
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis.
Ataxia Telangiectasia
Diversity of ATM gene mutations detected in patients with ataxia-telangiectasia.
Ataxia Telangiectasia
Diversity of ATM gene variants: a population-based genome data analysis for precision medicine.
Ataxia Telangiectasia
DNA Damage Activates TGF-? Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor T?RII.
Ataxia Telangiectasia
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin.
Ataxia Telangiectasia
DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs.
Ataxia Telangiectasia
DNA damage as a marker of brain damage in individuals with history of concussions.
Ataxia Telangiectasia
DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds.
Ataxia Telangiectasia
DNA damage checkpoint kinase Chk2 triggers replicative senescence.
Ataxia Telangiectasia
DNA damage checkpoints in stem cells, ageing and cancer.
Ataxia Telangiectasia
DNA damage induced by polyglutamine-expanded proteins.
Ataxia Telangiectasia
DNA damage mediated s and g(2) checkpoints in human embryonal carcinoma cells.
Ataxia Telangiectasia
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity.
Ataxia Telangiectasia
DNA Damage Repair and Telomere Length in Normal Breast, Preneoplastic Lesions, and Invasive Cancer.
Ataxia Telangiectasia
DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity.
Ataxia Telangiectasia
DNA damage response in nephrotoxic and ischemic kidney injury.
Ataxia Telangiectasia
DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes.
Ataxia Telangiectasia
DNA damage response is hijacked by human papillomaviruses to complete their life cycle.
Ataxia Telangiectasia
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Ataxia Telangiectasia
DNA Damage Response Signals Transduce Stress From Rheumatoid Arthritis Risk Factors Into T Cell Dysfunction.
Ataxia Telangiectasia
DNA Damage Response-Related Proteins in Gastric Cancer: ATM, Chk2 and p53 Expression and Their Prognostic Value.
Ataxia Telangiectasia
DNA damage responses in neural cells: Focus on the telomere.
Ataxia Telangiectasia
DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture.
Ataxia Telangiectasia
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.
Ataxia Telangiectasia
DNA damage signaling in response to double-strand breaks during mitosis.
Ataxia Telangiectasia
DNA damage signaling is activated during cancer progression in human colorectal carcinoma.
Ataxia Telangiectasia
DNA damage to a single chromosome end delays anaphase onset.
Ataxia Telangiectasia
DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria.
Ataxia Telangiectasia
DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide.
Ataxia Telangiectasia
DNA damage-dependent NF-?B activation: NEMO turns nuclear signaling inside out.
Ataxia Telangiectasia
DNA damage-induced activation of ATM and ATM-dependent signaling pathways.
Ataxia Telangiectasia
DNA damage-induced activation of ATM promotes ?-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells.
Ataxia Telangiectasia
DNA damage-induced activation of ATM promotes ?-TRCP-mediated Mdm2 ubiquitination and destruction.
Ataxia Telangiectasia
DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex.
Ataxia Telangiectasia
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Ataxia Telangiectasia
DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair.
Ataxia Telangiectasia
DNA Damage-Induced Transcription of Transposable Elements and Long Non-coding RNAs in Arabidopsis Is Rare and ATM-Dependent.
Ataxia Telangiectasia
DNA Damage-Sensing Kinases Mediate the Mouse 2-Cell Embryo's Response to Genotoxic Stress.
Ataxia Telangiectasia
DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.
Ataxia Telangiectasia
DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.
Ataxia Telangiectasia
DNA repair gene deficiency does not predispose human bronchial epithelial cells to benzo(a)pyrene-induced cell transformation.
Ataxia Telangiectasia
DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas.
Ataxia Telangiectasia
DNA structure-specific priming of ATR activation by DNA-PKcs.
Ataxia Telangiectasia
DNA-dependent protein kinase and Ataxia Telangiectasia Mutated (ATM) promote cell survival in response to NK314, a topoisomerase II? inhibitor.
Ataxia Telangiectasia
DNA-dependent protein kinase and related proteins.
Ataxia Telangiectasia
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
Ataxia Telangiectasia
DNA-Dependent Protein Kinase Catalytic Subunit: The Sensor for DNA Double-Strand Breaks Structurally and Functionally Related to Ataxia Telangiectasia Mutated.
Ataxia Telangiectasia
DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70.
Ataxia Telangiectasia
DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.
Ataxia Telangiectasia
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Ataxia Telangiectasia
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-??-IRF1-CIITA pathway.
Ataxia Telangiectasia
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.
Ataxia Telangiectasia
DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells.
Ataxia Telangiectasia
DNA-PK suppresses a p53-independent apoptotic response to DNA damage.
Ataxia Telangiectasia
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.
Ataxia Telangiectasia
DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.
Ataxia Telangiectasia
DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.
Ataxia Telangiectasia
DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.
Ataxia Telangiectasia
DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly.
Ataxia Telangiectasia
DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response.
Ataxia Telangiectasia
DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response.
Ataxia Telangiectasia
DNA-PKcs: A Multi-Faceted Player in DNA Damage Response.
Ataxia Telangiectasia
Does Ataxia Telangiectasia Mutated (ATM) protect testicular and germ cell DNA integrity by regulating the redox status?
Ataxia Telangiectasia
Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.
Ataxia Telangiectasia
Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation.
Ataxia Telangiectasia
Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells.
Ataxia Telangiectasia
Down-regulation of ATM protein in HRS cells of nodular sclerosis Hodgkin's lymphoma in children occurs in the absence of ATM gene inactivation.
Ataxia Telangiectasia
Down-regulation of Fer induces ROS levels accompanied by ATM and p53 activation in colon carcinoma cells.
Ataxia Telangiectasia
Down-regulation of NOX2 activity in phagocytes mediated by ATM-kinase dependent phosphorylation.
Ataxia Telangiectasia
Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.
Ataxia Telangiectasia
Downregulation of ATM Gene and Protein Expression in Canine Mammary Tumors.
Ataxia Telangiectasia
Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance.
Ataxia Telangiectasia
Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.
Ataxia Telangiectasia
Drosophila ATR in double-strand break repair.
Ataxia Telangiectasia
Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks.
Ataxia Telangiectasia
Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response.
Ataxia Telangiectasia
DUETTE: a phase II randomized, multicenter study to investigate the efficacy and tolerability of a second maintenance treatment in patients with platinum-sensitive relapsed epithelial ovarian cancer, who have previously received poly(ADP-ribose) polymerase (PARP) inhibitor maintenance treatment.
Ataxia Telangiectasia
Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest.
Ataxia Telangiectasia
Dynamic modeling of cellular response to DNA damage based on p53 stress response networks.
Ataxia Telangiectasia
Dynamic monitoring of oxidative DNA double-strand break and repair in cardiomyocytes.
Ataxia Telangiectasia
Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours.
Ataxia Telangiectasia
Early B-cell specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice.
Ataxia Telangiectasia
Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus.
Ataxia Telangiectasia
Early-stage apoptosis is associated with DNA-damage-independent ATM phosphorylation and chromatin decondensation in NIH3T3 fibroblasts.
Ataxia Telangiectasia
EBV encoded miRNA BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway.
Ataxia Telangiectasia
EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma.
Ataxia Telangiectasia
Effect of ATM heterozygosity on heritable DNA damage in mice following paternal F0 germline irradiation.
Ataxia Telangiectasia
Effect of ATM on inflammatory response and autophagy in renal tubular epithelial cells in LPS-induced septic AKI.
Ataxia Telangiectasia
Effect of ATM-111 (G>A) Polymorphism on Cancer Risk: A Meta-Analysis.
Ataxia Telangiectasia
Effect of ATR Inhibition in RT Response of HPV-Negative and HPV-Positive Head and Neck Cancers.
Ataxia Telangiectasia
Effect of Class Switch Recombination Defect on the Phenotype of Ataxia-Telangiectasia Patients.
Ataxia Telangiectasia
Effect of epigallocatechin-3-gallate (EGCG) on embryos inseminated with oxidative stress-induced DNA damage sperm.
Ataxia Telangiectasia
Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease.
Ataxia Telangiectasia
Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study.
Ataxia Telangiectasia
Effect of specific activation of ?-aminobutyric acid receptor in vivo on oxidative stress-induced damage after extended hepatectomy.
Ataxia Telangiectasia
Effect of TERT and ATM on gene expression profiles in human fibroblasts.
Ataxia Telangiectasia
Effects of aflatoxin B1 on the cell cycle distribution of splenocytes in chickens.
Ataxia Telangiectasia
Effects of Ataxia Telangiectasia Mutated (ATM) Genotypes and Smoking Habits on Lung Cancer Risk in Taiwan.
Ataxia Telangiectasia
Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis.
Ataxia Telangiectasia
Effects of low and high LET radiations on bystander human lung fibroblast cell survival.
Ataxia Telangiectasia
Effects of low dose ionizing radiation on DNA damage-caused pathways by reverse-phase protein array and Bayesian networks.
Ataxia Telangiectasia
Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma.
Ataxia Telangiectasia
Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro.
Ataxia Telangiectasia
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response.
Ataxia Telangiectasia
Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.
Ataxia Telangiectasia
Efficient reconstitution of hepatic microvasculature by endothelin receptor antagonism in liver sinusoidal endothelial cells.
Ataxia Telangiectasia
Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA.
Ataxia Telangiectasia
Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.
Ataxia Telangiectasia
Elevated DNA damage response in pancreatic cancer.
Ataxia Telangiectasia
Elevated Expression of Hepatoma Up-Regulated Protein Inhibits ?-Irradiation-Induced Apoptosis of Prostate Cancer Cells.
Ataxia Telangiectasia
Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
Ataxia Telangiectasia
Emerging strategies to target cancer metabolism and improve radiation therapy outcomes.
Ataxia Telangiectasia
Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Ataxia Telangiectasia
En Guard! The Interactions between Adenoviruses and the DNA Damage Response.
Ataxia Telangiectasia
Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response.
Ataxia Telangiectasia
Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.
Ataxia Telangiectasia
Endoplasmic reticulum stress and unfolded protein response in Atm-deficient thymocytes and thymic lymphoma cells are attributable to oxidative stress.
Ataxia Telangiectasia
Endothelin-1 and ?-melanocortin have redundant effects on global genome repair in UV-irradiated human melanocytes despite distinct signaling pathways.
Ataxia Telangiectasia
Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity.
Ataxia Telangiectasia
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.
Ataxia Telangiectasia
Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells.
Ataxia Telangiectasia
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells.
Ataxia Telangiectasia
Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage.
Ataxia Telangiectasia
Enhanced UV Resistance Role of Death Domain-Associated Protein in Human MDA-MB-231 Breast Cancer Cells by Regulation of G2 DNA Damage Checkpoint.
Ataxia Telangiectasia
Enhancement of DNA double-strand break induction and cell killing by K-shell absorption of phosphorus in human cell lines.
Ataxia Telangiectasia
Epidermal stem cells and cancer stem cells: insights into cancer and potential therapeutic strategies.
Ataxia Telangiectasia
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Ataxia Telangiectasia
Epigenetic Mechanisms of ATM Activation after Helicobacter pylori Infection.
Ataxia Telangiectasia
ER-Dependent Ca++-mediated Cytosolic ROS as an Effector for Induction of Mitochondrial Apoptotic and ATM-JNK Signal Pathways in Gallic Acid-treated Human Oral Cancer Cells.
Ataxia Telangiectasia
ERK kinases modulate the activation of PI3 kinase related kinases (PIKKs) in DNA damage response.
Ataxia Telangiectasia
Essential Role of Ubiquitin-Fold Modifier 1 Conjugation in DNA Damage Response.
Ataxia Telangiectasia
Establishing trusting partnerships for successful recruitment of American Indians to clinical trials.
Ataxia Telangiectasia
Ethanol metabolism activates cell cycle checkpoint kinase, Chk2.
Ataxia Telangiectasia
Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies.
Ataxia Telangiectasia
Evaluation of cytotoxicity and DNA damage response with analysis of intracellular ATM signaling pathways.
Ataxia Telangiectasia
Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer.
Ataxia Telangiectasia
Evaluation of the spatial distribution of gammaH2AX following ionizing radiation.
Ataxia Telangiectasia
Evaluation of [
Ataxia Telangiectasia
Evasion of early cellular response mechanisms following low level radiation-induced DNA damage.
Ataxia Telangiectasia
Evidence for pathogenicity of variant ATM Val1729Leu in a family with ataxia telangiectasia.
Ataxia Telangiectasia
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo.
Ataxia Telangiectasia
Evolutionary model of brain tumor circulating cells: Cellular galaxy.
Ataxia Telangiectasia
Excess growth hormone suppresses DNA damage repair in epithelial cells.
Ataxia Telangiectasia
Exploiting replicative stress in gynecological cancers as a therapeutic strategy.
Ataxia Telangiectasia
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Ataxia Telangiectasia
Exploring the Influence of Parameters on the p53 Response When Single-Stranded Breaks and Double-Stranded Breaks Coexist.
Ataxia Telangiectasia
Exploring the role of high-mobility group box 1 (HMGB1) protein in the pathogenesis of Huntington's disease.
Ataxia Telangiectasia
Exposure of the cytoplasm to low-dose X-rays modifies ataxia telangiectasia mutated-mediated DNA damage responses.
Ataxia Telangiectasia
Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer.
Ataxia Telangiectasia
Expression and maintenance of mitochondrial DNA: new insights into human disease pathology.
Ataxia Telangiectasia
Expression of HPV-induced DNA Damage Repair Factors Correlates With CIN Progression.
Ataxia Telangiectasia
Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression.
Ataxia Telangiectasia
Expression pattern of ataxia telangiectasia mutated (ATM), p53, Akt, and glycogen synthase kinase-3? in the striatum of rats treated with 3-nitropropionic acid.
Ataxia Telangiectasia
Expression patterns of the ATM gene in mammary tissues and their associations with breast cancer survival.
Ataxia Telangiectasia
Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia.
Ataxia Telangiectasia
Extracellular matrix metalloproteinase inducer (CD147/BSG/EMMPRIN)-induced radioresistance in cervical cancer by regulating the percentage of the cells in the G2/m phase of the cell cycle and the repair of DNA Double-strand Breaks (DSBs).
Ataxia Telangiectasia
Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.
Ataxia Telangiectasia
EZH2 Loss Drives Resistance to Carboplatin and Paclitaxel in Serous Ovarian Cancers Expressing ATM.
Ataxia Telangiectasia
Familial lymphoid neoplasms in patients with mantle cell lymphoma Familial lymphoid neoplasms in patients with mantle cell lymphoma.
Ataxia Telangiectasia
Familial pancreatic carcinoma in Jews.
Ataxia Telangiectasia
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
Ataxia Telangiectasia
Far-infrared irradiation inhibits breast cancer cell proliferation independently of DNA damage through increased nuclear Ca2+/calmodulin binding modulated-activation of checkpoint kinase 2.
Ataxia Telangiectasia
Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells.
Ataxia Telangiectasia
FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis.
Ataxia Telangiectasia
Fibroblasts from Retinoblastoma Patients Show Radiosensitivity Linked to Abnormal Localization of the ATM Protein.
Ataxia Telangiectasia
First international workshop of the ATM and cancer risk group (4-5 December 2019).
Ataxia Telangiectasia
First-in-Human Trial of the Oral Ataxia Telangiectasia and Rad3-Related Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors.
Ataxia Telangiectasia
Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract.
Ataxia Telangiectasia
Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.
Ataxia Telangiectasia
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.
Ataxia Telangiectasia
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
Ataxia Telangiectasia
FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage.
Ataxia Telangiectasia
Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families.
Ataxia Telangiectasia
Fresh and ozonized black carbon promoted DNA damage and repair responses in A549 cells.
Ataxia Telangiectasia
Functional Activation of ATM by the Prostate Cancer Suppressor NKX3.1.
Ataxia Telangiectasia
Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses.
Ataxia Telangiectasia
Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk.
Ataxia Telangiectasia
Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency.
Ataxia Telangiectasia
Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways.
Ataxia Telangiectasia
Functional classification of ATM variants in ataxia-telangiectasia patients.
Ataxia Telangiectasia
Functional interaction between FOXO3a and ATM regulates DNA damage response.
Ataxia Telangiectasia
Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit.
Ataxia Telangiectasia
Functional polymorphism rs189037 in the promoter region of ATM gene is associated with angiographically characterized coronary stenosis.
Ataxia Telangiectasia
Functional proteomic pattern identification under low dose ionizing radiation.
Ataxia Telangiectasia
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
Ataxia Telangiectasia
Functional role for the c-Abl tyrosine kinase in meiosis I.
Ataxia Telangiectasia
Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript.
Ataxia Telangiectasia
Functions and regulation of Artemis: a goddess in the maintenance of genome integrity.
Ataxia Telangiectasia
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses.
Ataxia Telangiectasia
G-quadruplexes induce apoptosis in tumor cells.
Ataxia Telangiectasia
G2 arrest in response to topoisomerase II inhibitors: the role of p53.
Ataxia Telangiectasia
G2 DNA damage checkpoint inhibition and antimitotic activity of 13-hydroxy-15-oxozoapatlin.
Ataxia Telangiectasia
Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice.
Ataxia Telangiectasia
Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells.
Ataxia Telangiectasia
Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway.
Ataxia Telangiectasia
Gallic acid induces DNA damage and inhibits DNA repair-associated protein expression in human oral cancer SCC-4 cells.
Ataxia Telangiectasia
Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
Ataxia Telangiectasia
Gamma-H2AX - a novel biomarker for DNA double-strand breaks.
Ataxia Telangiectasia
Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1.
Ataxia Telangiectasia
Gamma-radiation-induced phosphorylation of p53 on serine 15 is dose-dependent in MOLT-4 leukaemia cells.
Ataxia Telangiectasia
Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated.
Ataxia Telangiectasia
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.
Ataxia Telangiectasia
Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX.
Ataxia Telangiectasia
Genetic Aberration Analysis in Thai Colorectal Adenoma and Early-Stage Adenocarcinoma Patients by Whole-Exome Sequencing.
Ataxia Telangiectasia
Genetic features of B-cell chronic lymphocytic leukemia.
Ataxia Telangiectasia
Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA-PKcs in human cells.
Ataxia Telangiectasia
Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway.
Ataxia Telangiectasia
Genetic link between heme oxygenase and the signaling pathway of DNA damage in Drosophila melanogaster.
Ataxia Telangiectasia
Genetic polymorphism contributes to 131I radiotherapy-induced toxicities in patients with differentiated thyroid cancer.
Ataxia Telangiectasia
Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk.
Ataxia Telangiectasia
Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk.
Ataxia Telangiectasia
Genetic testing for hereditary prostate cancer: Current status and limitations.
Ataxia Telangiectasia
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
Ataxia Telangiectasia
Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-?B/IKK pathway-induced apoptosis.
Ataxia Telangiectasia
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.
Ataxia Telangiectasia
Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells.
Ataxia Telangiectasia
Genomic Characterization of Metformin Hepatic Response.
Ataxia Telangiectasia
Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.
Ataxia Telangiectasia
Genomic instability--an evolving hallmark of cancer.
Ataxia Telangiectasia
Genotoxic Damage Activates the AMPK-?1 Isoform in the Nucleus via Ca
Ataxia Telangiectasia
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Ataxia Telangiectasia
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.
Ataxia Telangiectasia
Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution.
Ataxia Telangiectasia
Genotype-phenotype correlations in ataxia telangiectasia patients with ATM c.3576G>A and c.8147T>C mutations.
Ataxia Telangiectasia
Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia.
Ataxia Telangiectasia
Germline genetic variants in men with prostate cancer and one or more additional cancers.
Ataxia Telangiectasia
Germline PALB2, ATM variants in a patient with breast and ovarian cancer at risk for familial cancer syndrome: Is there a role for risk-reducing salpingo-oophorectomy?
Ataxia Telangiectasia
Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers.
Ataxia Telangiectasia
Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice.
Ataxia Telangiectasia
GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions.
Ataxia Telangiectasia
GPR68 Contributes to Persistent Acidosis-Induced Activation of AGC Kinases and Tyrosine Phosphorylation in Organotypic Hippocampal Slices.
Ataxia Telangiectasia
Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells.
Ataxia Telangiectasia
Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation.
Ataxia Telangiectasia
Growth Hormone Induces Colon DNA Damage Independent of IGF-1.
Ataxia Telangiectasia
Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition.
Ataxia Telangiectasia
Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells.
Ataxia Telangiectasia
H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions.
Ataxia Telangiectasia
H2AX gene does not have a modifier effect on ataxia-telangiectasia phenotype.
Ataxia Telangiectasia
H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase.
Ataxia Telangiectasia
H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation.
Ataxia Telangiectasia
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Ataxia Telangiectasia
Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation.
Ataxia Telangiectasia
Hairpin-end conformation of adeno-associated virus genome determines interactions with DNA-repair pathways.
Ataxia Telangiectasia
Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction.
Ataxia Telangiectasia
HDMX folds the nascent p53 mRNA following activation by the ATM kinase.
Ataxia Telangiectasia
Health risks for ataxia-telangiectasia mutated heterozygotes: A systematic review, Meta-analysis and evidence-based guideline.
Ataxia Telangiectasia
Heart failure and diabetes: role of ATM.
Ataxia Telangiectasia
Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.
Ataxia Telangiectasia
Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine.
Ataxia Telangiectasia
Hedamycin, a DNA alkylator, induces (gamma)H2AX and chromosome aberrations: involvement of phosphatidylinositol 3-kinase-related kinases and DNA replication fork movement.
Ataxia Telangiectasia
Helichrysetin Induces DNA Damage that Triggers JNK-Mediated Apoptosis in Ca Ski Cells.
Ataxia Telangiectasia
Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein.
Ataxia Telangiectasia
Hepatitis B virus X protein activates E3 ubiquitin ligase Siah-1 to control virus propagation via a negative feedback loop.
Ataxia Telangiectasia
Hepatitis B virus X protein activates the ATM-Chk2 pathway and delays cell cycle progression.
Ataxia Telangiectasia
Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase.
Ataxia Telangiectasia
Hepatitis C virus core activates proteasomal activator 28? expression via upregulation of p53 levels to control virus propagation.
Ataxia Telangiectasia
Hepatitis C virus infection downregulates the ligands of the activating receptor NKG2D.
Ataxia Telangiectasia
Hepatitis C virus mediated inhibition of miR-181c activates ATM signaling and promotes hepatocyte growth.
Ataxia Telangiectasia
Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm.
Ataxia Telangiectasia
Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses.
Ataxia Telangiectasia
Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice.
Ataxia Telangiectasia
Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor.
Ataxia Telangiectasia
High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways.
Ataxia Telangiectasia
High mobility group protein-mediated transcription requires DNA damage marker ?-H2AX.
Ataxia Telangiectasia
High pATM is Associated With Poor Local Control in Supraglottic Cancer Treated With Radiotherapy.
Ataxia Telangiectasia
High resistance to X-rays and therapeutic carbon ions in glioblastoma cells bearing dysfunctional ATM associates with intrinsic chromosomal instability.
Ataxia Telangiectasia
High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy.
Ataxia Telangiectasia
Histone chaperones play crucial roles in maintenance of stem cell niche during plant root development.
Ataxia Telangiectasia
Histone deacetylase 2 is involved in DNA damage-mediated cell death of human osteosarcoma cells through stimulation of the ATM/p53 pathway.
Ataxia Telangiectasia
Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis?
Ataxia Telangiectasia
Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling.
Ataxia Telangiectasia
Histone H2AX Is Involved in FoxO3a-Mediated Transcriptional Responses to Ionizing Radiation to Maintain Genome Stability.
Ataxia Telangiectasia
Histone H2AX phosphorylation independent of ATM after X-irradiation in mouse liver and kidney in situ.
Ataxia Telangiectasia
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.
Ataxia Telangiectasia
Histopathological features of breast cancer in carriers of ATM gene variants.
Ataxia Telangiectasia
HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents.
Ataxia Telangiectasia
HMGA1 protein is a novel target of the ATM kinase.
Ataxia Telangiectasia
HMGA2 Inhibits Apoptosis through Interaction with ATR-CHK1 Signaling Complex in Human Cancer Cells.
Ataxia Telangiectasia
Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.
Ataxia Telangiectasia
Homeodomain Proteins Directly Regulate ATM Kinase Activity.
Ataxia Telangiectasia
Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.
Ataxia Telangiectasia
Homeostatic regulation of meiotic DSB formation by ATM/ATR.
Ataxia Telangiectasia
HOMOLOGOUS RECOMBINATIONAL REPAIR FACTORS ARE RECRUITED AND LOADED ONTO THE VIRAL DNA GENOME IN EPSTEIN-BARR VIRUS REPLICATION COMPARTMENTS.
Ataxia Telangiectasia
Homozygous pathogenic variant in BRAT1 associated with nonprogressive cerebellar ataxia.
Ataxia Telangiectasia
Host DNA damage response facilitates African swine fever virus infection.
Ataxia Telangiectasia
How adeno-associated virus Rep78 protein arrests cells completely in S phase.
Ataxia Telangiectasia
How Human Papillomavirus Replication and Immune Evasion Strategies Take Advantage of the Host DNA Damage Repair Machinery.
Ataxia Telangiectasia
HPV infection associated DNA damage correlated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China.
Ataxia Telangiectasia
hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.
Ataxia Telangiectasia
Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.
Ataxia Telangiectasia
HSV-1 Hijacks the Host DNA Damage Response in Corneal Epithelial Cells through ICP4-Mediated Activation of ATM.
Ataxia Telangiectasia
hTERT-immortalized cells useful for analyzing effects of low-dose-rate radiation on human cells.
Ataxia Telangiectasia
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection.
Ataxia Telangiectasia
Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability.
Ataxia Telangiectasia
Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response.
Ataxia Telangiectasia
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins.
Ataxia Telangiectasia
Human herpesvirus 6B induces cell cycle arrest concomitant with p53 phosphorylation and accumulation in T cells.
Ataxia Telangiectasia
Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.
Ataxia Telangiectasia
Human Kinase/Phosphatase-Wide RNAi Screening Identified Checkpoint Kinase 2 as a Cellular Factor Facilitating Japanese Encephalitis Virus Infection.
Ataxia Telangiectasia
Human microcephaly.
Ataxia Telangiectasia
Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.
Ataxia Telangiectasia
Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways.
Ataxia Telangiectasia
Human papillomaviruses recruit cellular DNA repair and homologous recombination factors to viral replication centers.
Ataxia Telangiectasia
Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection.
Ataxia Telangiectasia
Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199.
Ataxia Telangiectasia
Human SMG-1 is Involved in Gemcitabine-Induced Primary microRNA-155/BIC Up-Regulation in Human Pancreatic Cancer PANC-1 Cells.
Ataxia Telangiectasia
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.
Ataxia Telangiectasia
Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.
Ataxia Telangiectasia
HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells.
Ataxia Telangiectasia
Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence.
Ataxia Telangiectasia
Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction.
Ataxia Telangiectasia
Hypersensitivity to DNA damage in plant stem cell niches.
Ataxia Telangiectasia
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.
Ataxia Telangiectasia
Hypoxia promotes radioresistance of CD133-positive Hep-2 human laryngeal squamous carcinoma cells in vitro.
Ataxia Telangiectasia
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
Ataxia Telangiectasia
Hypoxic preconditioning decreases nuclear factor ?B activity via Disrupted in Schizophrenia-1.
Ataxia Telangiectasia
Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library.
Ataxia Telangiectasia
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.
Ataxia Telangiectasia
Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease.
Ataxia Telangiectasia
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines.
Ataxia Telangiectasia
Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.
Ataxia Telangiectasia
Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents.
Ataxia Telangiectasia
Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.
Ataxia Telangiectasia
Identification of aberrantly methylated differentially expressed genes in breast cancer by integrated bioinformatics analysis.
Ataxia Telangiectasia
Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression.
Ataxia Telangiectasia
Identification of ATM mutations in Korean siblings with ataxia-telangiectasia.
Ataxia Telangiectasia
Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.
Ataxia Telangiectasia
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
Ataxia Telangiectasia
Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells.
Ataxia Telangiectasia
Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.
Ataxia Telangiectasia
Identification of Lethal microRNAs Specific for Head and Neck Cancer.
Ataxia Telangiectasia
Identification of proteins in the hamster DNA end-binding complex.
Ataxia Telangiectasia
Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.
Ataxia Telangiectasia
Identification of Three Small Molecules That Can Selectively Influence Cellular Manganese Levels in a Mouse Striatal Cell Model.
Ataxia Telangiectasia
Identification of two ATR-dependent phosphorylation sites on coronavirus nucleocapsid protein with nonessential functions in viral replication and infectivity in cultured cells.
Ataxia Telangiectasia
Identification of Two Novel Mutations in the ATM Gene from Patients with Ataxia-Telangiectasia by Whole Exome Sequencing.
Ataxia Telangiectasia
IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Ataxia Telangiectasia
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
Ataxia Telangiectasia
IL-1? Inflammatory Cytokine-Induced TP63 Isoform ?NP63? Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells.
Ataxia Telangiectasia
Image-Based High Content Screening: Automating the Quantification Process for DNA Damage-Induced Foci.
Ataxia Telangiectasia
Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts.
Ataxia Telangiectasia
Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks.
Ataxia Telangiectasia
Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates.
Ataxia Telangiectasia
Immunodeficiency in ataxia telangiectasia is correlated strongly with the presence of two null mutations in the ataxia telangiectasia mutated gene.
Ataxia Telangiectasia
Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis.
Ataxia Telangiectasia
Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis.
Ataxia Telangiectasia
Impact of X-irradiation on microglia.
Ataxia Telangiectasia
Impaired DNA Repair Fidelity in a Breast Cancer Patient With Adverse Reactions to Radiotherapy.
Ataxia Telangiectasia
Impaired insulin-stimulated glucose transport in ATM-deficient mouse skeletal muscle.
Ataxia Telangiectasia
Impaired up-regulation of polo-like kinase 2 in B-cell chronic lymphocytic leukaemia lymphocytes resistant to fludarabine and 2-chlorodeoxyadenosine: a potential marker of defective damage response.
Ataxia Telangiectasia
Implication of the transcription factor E2F-1 in the modulation of neuronal apoptosis.
Ataxia Telangiectasia
Improved ataxia telangiectasia mutated kinase inhibitor KU60019 provides a promising treatment strategy for non-invasive breast cancer.
Ataxia Telangiectasia
Improving Radiation Response in Glioblastoma Using ECO/siRNA Nanoparticles Targeting DNA Damage Repair.
Ataxia Telangiectasia
In Silico-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma.
Ataxia Telangiectasia
In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells.
Ataxia Telangiectasia
Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells.
Ataxia Telangiectasia
Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia.
Ataxia Telangiectasia
Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage.
Ataxia Telangiectasia
Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia.
Ataxia Telangiectasia
Increased expression of CHK2 in human gastric carcinomas harboring p53 mutations.
Ataxia Telangiectasia
Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history.
Ataxia Telangiectasia
Increased radiation toxicity with germline ATM variant of uncertain clinical significance.
Ataxia Telangiectasia
Increased Regeneration Following Stress-Induced Lung Injury in Bleomycin-Treated Chimeric Mice with CD44 Knockout Mesenchymal Cells.
Ataxia Telangiectasia
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.
Ataxia Telangiectasia
Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells.
Ataxia Telangiectasia
Increased transferrin receptor expression following 11q23 deletion as a mechanism of malignant progression in chronic lymphocytic leukemia.
Ataxia Telangiectasia
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
Ataxia Telangiectasia
Individual differences in chromosomal aberrations after in vitro irradiation of cells from healthy individuals, cancer and cancer susceptibility syndrome patients.
Ataxia Telangiectasia
Individual Radiosensitivity Assessment of the Families of Ataxia-Telangiectasia Patients by G2-Checkpoint Abrogation.
Ataxia Telangiectasia
Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.
Ataxia Telangiectasia
Induction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells.
Ataxia Telangiectasia
Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.
Ataxia Telangiectasia
Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".
Ataxia Telangiectasia
Induction of DNA Damage Signaling upon Rift Valley Fever Virus Infection Results in Cell Cycle Arrest and Increased Viral Replication.
Ataxia Telangiectasia
Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer.
Ataxia Telangiectasia
Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine.
Ataxia Telangiectasia
Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.
Ataxia Telangiectasia
Infection of a Single Cell Line with Distinct Strains of Human Cytomegalovirus Can Result in Large Variations in Virion Production and Facilitate Efficient Screening of Virus Protein Function.
Ataxia Telangiectasia
Inflammation, a significant player of Ataxia-Telangiectasia pathogenesis?
Ataxia Telangiectasia
Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis.
Ataxia Telangiectasia
Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells.
Ataxia Telangiectasia
Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis.
Ataxia Telangiectasia
Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related (ATR) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer.
Ataxia Telangiectasia
Inhibition of Ataxia-Telangiectasia Mutated by Antisense Oligonucleotide Nanoparticles Induces Radiosensitization of Head and Neck Squamous-Cell Carcinoma in Mice.
Ataxia Telangiectasia
Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons.
Ataxia Telangiectasia
Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining.
Ataxia Telangiectasia
Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors.
Ataxia Telangiectasia
Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway.
Ataxia Telangiectasia
Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer.
Ataxia Telangiectasia
Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress.
Ataxia Telangiectasia
Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma.
Ataxia Telangiectasia
Inhibition of DNA repair protein RAD51 affects porcine preimplantation embryo development.
Ataxia Telangiectasia
Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells.
Ataxia Telangiectasia
Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation.
Ataxia Telangiectasia
Inhibition of DNA?PK activity sensitizes A549 cells to X?ray irradiation by inducing the ATM?dependent DNA damage response.
Ataxia Telangiectasia
Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation.
Ataxia Telangiectasia
Inhibition of hsp90 compromises the DNA damage response to radiation.
Ataxia Telangiectasia
Inhibition of p21-activated kinase 4 expression suppresses the proliferation of Hep-2 laryngeal carcinoma cells via activation of the ATM/Chk1/2/p53 pathway.
Ataxia Telangiectasia
Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status.
Ataxia Telangiectasia
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Ataxia Telangiectasia
Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.
Ataxia Telangiectasia
Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.
Ataxia Telangiectasia
Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells.
Ataxia Telangiectasia
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.
Ataxia Telangiectasia
Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.
Ataxia Telangiectasia
Inhibitor of Apoptosis Proteins Determines Glioblastoma Stem-Like Cell Fate in an Oxygen-Dependent Manner.
Ataxia Telangiectasia
Inhibitory effect of alpha-lipoic acid on mitochondrial dysfunction and interleukin-8 expression in interleukin-1beta-stimulated ataxia teleangiectasia fibroblasts.
Ataxia Telangiectasia
Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.
Ataxia Telangiectasia
Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1.
Ataxia Telangiectasia
Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity.
Ataxia Telangiectasia
Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.
Ataxia Telangiectasia
Insulin-like growth factor-1 attenuates cisplatin-induced gammaH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer.
Ataxia Telangiectasia
Insulin-like growth factor-1 receptor knockdown enhances radiosensitivity via the HIF-1? pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells.
Ataxia Telangiectasia
INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells.
Ataxia Telangiectasia
Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer.
Ataxia Telangiectasia
Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data.
Ataxia Telangiectasia
Integrated signaling in developing lymphocytes: the role of DNA damage responses.
Ataxia Telangiectasia
Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells.
Ataxia Telangiectasia
Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation.
Ataxia Telangiectasia
Interleukin 6 trigged ataxia-telangiectasia mutated activation facilitates lung cancer metastasis via MMP-3/MMP-13 up-regulation.
Ataxia Telangiectasia
Interleukin 6-triggered ataxia-telangiectasia mutated kinase activation facilitates epithelial-to-mesenchymal transition in lung cancer by upregulating vimentin expression.
Ataxia Telangiectasia
Interplay between ATM and ATR in the regulation of common fragile site stability.
Ataxia Telangiectasia
Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest.
Ataxia Telangiectasia
Interstitial deletion in 3q in a patient with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and microcephaly, mild mental retardation and growth delay: clinical report and review of the literature.
Ataxia Telangiectasia
Intestinal inflammation induces genotoxicity to extraintestinal tissues and cell types in mice.
Ataxia Telangiectasia
INTS3 controls the hSSB1-mediated DNA damage response.
Ataxia Telangiectasia
Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation.
Ataxia Telangiectasia
Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation.
Ataxia Telangiectasia
Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition.
Ataxia Telangiectasia
Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells.
Ataxia Telangiectasia
Involvement of DNA-PK and ATM in radiation- and heat-induced DNA damage recognition and apoptotic cell death.
Ataxia Telangiectasia
Involvement of Host ATR-CHK1 Pathway in Hepatitis B Virus Covalently Closed Circular DNA Formation.
Ataxia Telangiectasia
Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Ataxia Telangiectasia
Involvement of the role of Chk1 in lithium-induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells.
Ataxia Telangiectasia
Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma.
Ataxia Telangiectasia
Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
Ataxia Telangiectasia
Ionizing radiation can induce GSK-3beta phosphorylation and NF-kappaB transcriptional transactivation in ATM-deficient fibroblasts.
Ataxia Telangiectasia
Ionizing Radiation deregulates the microRNA expression profile in differentiated thyroid cells.
Ataxia Telangiectasia
Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells.
Ataxia Telangiectasia
Ionizing radiation enhances double-strand-break repair in rapamycin-treated ataxia telangiectasia lymphoblasts.
Ataxia Telangiectasia
Ionizing radiation induced signaling of DNA damage response molecules in RAW 264.7 and CD4(+) T cells.
Ataxia Telangiectasia
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Ataxia Telangiectasia
Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells.
Ataxia Telangiectasia
Ionizing radiation response of primary normal human lens epithelial cells.
Ataxia Telangiectasia
Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related.
Ataxia Telangiectasia
IRF1 Negatively Regulates Oncogenic KPNA2 Expression Under Growth Stimulation and Hypoxia in Lung Cancer Cells.
Ataxia Telangiectasia
Iron loading and oxidative stress in the Atm-/- mouse liver.
Ataxia Telangiectasia
Irradiation-induced G2/M checkpoint response requires ERK1/2 activation.
Ataxia Telangiectasia
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Ataxia Telangiectasia
Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes.
Ataxia Telangiectasia
Isoliquiritigenin causes DNA damage and inhibits ATM expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma.
Ataxia Telangiectasia
Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair.
Ataxia Telangiectasia
Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias.
Ataxia Telangiectasia
It takes three to the DNA damage response tango.
Ataxia Telangiectasia
IVS10-6T>G, an ancient ATM germline mutation linked with breast cancer.
Ataxia Telangiectasia
Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells.
Ataxia Telangiectasia
JS-K, a nitric oxide prodrug, induces DNA damage and apoptosis in HBV-positive hepatocellular carcinoma HepG2.2.15 cell.
Ataxia Telangiectasia
Kaposi's sarcoma-associated herpesvirus induces the ATM and H2AX DNA damage response early during de novo infection of primary endothelial cells, which play roles in latency establishment.
Ataxia Telangiectasia
KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells.
Ataxia Telangiectasia
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis.
Ataxia Telangiectasia
Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80.
Ataxia Telangiectasia
KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8.
Ataxia Telangiectasia
Knockdown of RNF2 enhances radiosensitivity of lung squamous cell carcinoma cells.
Ataxia Telangiectasia
L-carnitine enhances resistance to oxidative stress by reducing DNA damage in Ataxia telangiectasia cells.
Ataxia Telangiectasia
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1.
Ataxia Telangiectasia
Lack of ATM induces structural and functional changes in the heart: Role in ?-adrenergic receptor-stimulated apoptosis.
Ataxia Telangiectasia
Lack of effect of RuvB-like proteins on DNA damage signaling activation.
Ataxia Telangiectasia
Lack of involvement of ataxia telangiectasia mutated (ATM) in regulation of nuclear factor-kappaB (NF-kappaB) in human diploid fibroblasts.
Ataxia Telangiectasia
Late-onset autosomal recessive cerebellar ataxia and neuropathy with a novel splicing mutation in the ATM gene.
Ataxia Telangiectasia
Latex of Euphorbia antiquorum-induced S-phase arrest via active ATM kinase and MAPK pathways in human cervical cancer HeLa cells.
Ataxia Telangiectasia
LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.
Ataxia Telangiectasia
Lethal neonatal rigidity and multifocal seizure syndrome with a new mutation in BRAT1.
Ataxia Telangiectasia
Lethal Neonatal Rigidity and Multifocal Seizure Syndrome--A Misnamed Disorder?
Ataxia Telangiectasia
Level of reactive oxygen species induced by p21(WAF(1)CIP(1)) is critical for the determination of cell fate.
Ataxia Telangiectasia
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
Ataxia Telangiectasia
Linking ATM Promoter Methylation to Cell Cycle Protein Expression in Brain Tumor Patients: Cellular Molecular Triangle Correlation in ATM Territory.
Ataxia Telangiectasia
Linking loss of sodium-iodide symporter expression to DNA damage.
Ataxia Telangiectasia
LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.
Ataxia Telangiectasia
LMTK3 confers chemo-resistance in breast cancer.
Ataxia Telangiectasia
Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers is important for its inhibitory effect on viral DNA accumulation.
Ataxia Telangiectasia
Long Noncoding RNA FAM201A Mediates the Radiosensitivity of Esophageal Squamous Cell Cancer by Regulating ATM and mTOR Expression via miR-101.
Ataxia Telangiectasia
Long-term in vivo effects of cisplatin on gamma-H2AX foci signaling in peripheral lymphocytes of tumor patients after irradiation.
Ataxia Telangiectasia
Loperamide, an antidiarrheal agent, induces apoptosis and DNA damage in leukemia cells.
Ataxia Telangiectasia
Loss of ATM positively regulates Rac1 activity and cellular migration through oxidative stress.
Ataxia Telangiectasia
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.
Ataxia Telangiectasia
Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome.
Ataxia Telangiectasia
Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism.
Ataxia Telangiectasia
Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis.
Ataxia Telangiectasia
Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium.
Ataxia Telangiectasia
Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin.
Ataxia Telangiectasia
Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC.
Ataxia Telangiectasia
Low ATM expression and progression-free and overall survival in advanced gastric cancer patients treated with first-line XELOX chemotherapy.
Ataxia Telangiectasia
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
Ataxia Telangiectasia
Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer.
Ataxia Telangiectasia
Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.
Ataxia Telangiectasia
Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.
Ataxia Telangiectasia
Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells.
Ataxia Telangiectasia
Low prevalence and independent prognostic role of del(11q) in Chinese patients with chronic lymphocytic leukemia.
Ataxia Telangiectasia
Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells.
Ataxia Telangiectasia
Low-dose irradiation promotes proliferation of the human breast cancer MDA-MB-231 cells through accumulation of mutant P53.
Ataxia Telangiectasia
Lower ataxia telangiectasia mutated (ATM) mRNA expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients.
Ataxia Telangiectasia
LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.
Ataxia Telangiectasia
Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma.
Ataxia Telangiectasia
Lymphocyte development: integration of DNA damage response signaling.
Ataxia Telangiectasia
Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks.
Ataxia Telangiectasia
Maize ATR safeguards genome stability during kernel development to prevent early endosperm endocycle onset and cell death.
Ataxia Telangiectasia
Mammosphere cells from high-passage MCF7 cell line show variable loss of tumorigenicity and radioresistance.
Ataxia Telangiectasia
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
Ataxia Telangiectasia
Management of Individuals With a Mutation in the Ataxia Telangiectasia Mutated Gene.
Ataxia Telangiectasia
Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.
Ataxia Telangiectasia
Mathematical Model of ATM Activation and Chromatin Relaxation by Ionizing Radiation.
Ataxia Telangiectasia
Matrin-3 is essential for fibroblast growth factor 2-dependent maintenance of neural stem cells.
Ataxia Telangiectasia
MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells.
Ataxia Telangiectasia
MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
Measurement of DNA-Dependent Protein Kinase Phosphorylation Using Flow Cytometry Provides a Reliable Estimate of DNA Repair Capacity.
Ataxia Telangiectasia
Mechanism of diepoxybutane-induced p53 regulation in human cells.
Ataxia Telangiectasia
Mechanisms of Ataxia Telangiectasia Mutated (ATM) Control in the DNA Damage Response to Oxidative Stress, Epigenetic Regulation, and Persistent Innate Immune Suppression Following Sepsis.
Ataxia Telangiectasia
Mechanisms of ATM Activation.
Ataxia Telangiectasia
Mechanisms of Non-canonical Activation of Ataxia Telangiectasia Mutated.
Ataxia Telangiectasia
Mechanisms Underlying the Suppression of Chromosome Rearrangements by Ataxia-Telangiectasia Mutated.
Ataxia Telangiectasia
Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.
Ataxia Telangiectasia
Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.
Ataxia Telangiectasia
Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF.
Ataxia Telangiectasia
MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.
Ataxia Telangiectasia
Melanoma cells express elevated levels of phosphorylated histone H2AX foci.
Ataxia Telangiectasia
Merkel Cell Polyomavirus DNA Replication Induces Senescence in Human Dermal Fibroblasts in a Kap1/Trim28-Dependent Manner.
Ataxia Telangiectasia
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Radiation-Induced Lung Injury via miRNA-214-3p.
Ataxia Telangiectasia
Mesenchymal stromal cells are genetically stable under a hostile in vivo-like scenario as revealed by in vitro micronucleus test.
Ataxia Telangiectasia
Meta-analysis of Associations between ATM Asp1853Asn and TP53 Arg72Pro Polymorphisms and Adverse Effects of Cancer Radiotherapy.
Ataxia Telangiectasia
Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells.
Ataxia Telangiectasia
Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR.
Ataxia Telangiectasia
Metastasis-associated gene 1 (MTA1) enhances cisplatin resistance of malignant pleural mesothelioma by ATR-Chk1-mediated DNA repair.
Ataxia Telangiectasia
Metformin activates an Ataxia Telangiectasia Mutated (ATM)/Chk2-regulated DNA damage-like response.
Ataxia Telangiectasia
Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer.
Ataxia Telangiectasia
Metformin: a cheap and well-tolerated drug that provides benefits for viral infections.
Ataxia Telangiectasia
Methylation of the ataxia telangiectasia mutated gene (ATM) promoter as a radiotherapy outcome biomarker in patients with hepatocellular carcinoma.
Ataxia Telangiectasia
Methylation status of genes in papillary thyroid carcinoma.
Ataxia Telangiectasia
Methylglyoxal-bis(guanylhydrazone), a polyamine analogue, sensitized ?-radiation-induced cell death in HL-60 leukemia cells Sensitizing effect of MGBG on ?-radiation-induced cell death.
Ataxia Telangiectasia
Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin.
Ataxia Telangiectasia
Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.
Ataxia Telangiectasia
Microglial Self-Recognition STINGs in A-T Neurodegeneration.
Ataxia Telangiectasia
MicroRNA Analysis of ATM-Deficient Cells Indicate PTEN and CCDN1 as Potential Biomarkers of Radiation Response.
Ataxia Telangiectasia
microRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation.
Ataxia Telangiectasia
MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer.
Ataxia Telangiectasia
MicroRNA-18a enhances the radiosensitivity of cervical cancer cells by promoting radiation-induced apoptosis.
Ataxia Telangiectasia
MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells.
Ataxia Telangiectasia
MicroRNA-223 Enhances Radiation Sensitivity of U87MG Cells In Vitro and In Vivo by Targeting Ataxia Telangiectasia Mutated.
Ataxia Telangiectasia
MicroRNA-361-5p slows down gliomas development through regulating UBR5 to elevate ATMIN protein expression.
Ataxia Telangiectasia
Microvesicles Contribute to the Bystander Effect of DNA Damage.
Ataxia Telangiectasia
Microwave hyperthermia promotes caspase?3-dependent apoptosis and induces G2/M checkpoint arrest via the ATM pathway in non?small cell lung cancer cells.
Ataxia Telangiectasia
MiR-100 regulates cell viability and apoptosis by targeting ATM in pediatric acute myeloid leukemia.
Ataxia Telangiectasia
miR-15b/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung.
Ataxia Telangiectasia
miR-181a and miR-630 regulate cisplatin-induced cancer cell death.
Ataxia Telangiectasia
miR-181a promotes G1/S transition and cell proliferation in pediatric acute myeloid leukemia by targeting ATM.
Ataxia Telangiectasia
miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase.
Ataxia Telangiectasia
miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase.
Ataxia Telangiectasia
MiR-203 inhibits tumor invasion and metastasis in gastric cancer by ATM.
Ataxia Telangiectasia
miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13.
Ataxia Telangiectasia
miR-26a attenuates cardiac apoptosis and fibrosis by targeting ataxia-telangiectasia mutated in myocardial infarction.
Ataxia Telangiectasia
MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated.
Ataxia Telangiectasia
miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary.
Ataxia Telangiectasia
MiR-2964a-5p binding site SNP regulates
Ataxia Telangiectasia
miR-30a can inhibit DNA replication by targeting RPA1 thus slowing cancer cell proliferation.
Ataxia Telangiectasia
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.
Ataxia Telangiectasia
Mismatch repair and DNA damage signalling.
Ataxia Telangiectasia
Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement.
Ataxia Telangiectasia
Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells.
Ataxia Telangiectasia
Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species.
Ataxia Telangiectasia
Mitochondrial dysfunction in ataxia-telangiectasia.
Ataxia Telangiectasia
Mitochondrial Dysfunctions Regulated Radioresistance through Mitochondria-to-Nucleus Retrograde Signaling Pathway of NF-?B/PI3K/AKT2/mTOR.
Ataxia Telangiectasia
Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma.
Ataxia Telangiectasia
Mobile phone signal exposure triggers a hormesis-like effect in Atm(+/+) and Atm(-/-) mouse embryonic fibroblasts.
Ataxia Telangiectasia
Mode of ATM-dependent suppression of chromosome translocation.
Ataxia Telangiectasia
Modeling ATM mutant proteins from missense changes confirms retained kinase activity.
Ataxia Telangiectasia
Modeling the role of p53 pulses in DNA damage- induced cell death decision.
Ataxia Telangiectasia
Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.
Ataxia Telangiectasia
Modulation of cellular senescence in fibroblasts and dermal papillae cells in vitro.
Ataxia Telangiectasia
Modulation of chromatin conformation by the histone deacetylase inhibitor trichostatin A promotes the removal of radiation-induced lesions in ataxia telangiectasia cell lines.
Ataxia Telangiectasia
Modulation of DNA damage response by targeting ATM kinase using newly synthesized di-phenoxy acetamide (DPA) analogs to induce anti-neoplasia.
Ataxia Telangiectasia
Modulation of DNA repair capacity by Antaxia-telangiectasia mutated gene polymorphisms among polycyclic aromatic hydrocarbons exposed workers.
Ataxia Telangiectasia
Modulation of hypersensitivity to oxidative DNA damage in ATM defective cells induced by potassium bromate by inhibition of the Poly (ADP-ribose) polymerase (PARP).
Ataxia Telangiectasia
Modulation of the DNA repair system and ATR-p53 mediated apoptosis is relevant for tributyltin-induced genotoxic effects in human hepatoma G2 cells.
Ataxia Telangiectasia
Molecular and Radiological Features of Microsatellite Stable Colorectal Cancer Cases With Dramatic Responses to Immunotherapy.
Ataxia Telangiectasia
Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.
Ataxia Telangiectasia
Molecular characteristics of immunogenic cancer cell death.
Ataxia Telangiectasia
Molecular characterization of apoptosis induced by CARF silencing in human cancer cells.
Ataxia Telangiectasia
Molecular cloning and characterization of the catalytic domain of zebrafish homologue of the ataxia-telangiectasia mutated gene.
Ataxia Telangiectasia
Molecular cloning and functional characterization of zebrafish ATM.
Ataxia Telangiectasia
Molecular imaging of the ATM kinase activity.
Ataxia Telangiectasia
Molecular integrity and global gene expression of breast and lung cancer stem cells under long-term storage and recovery.
Ataxia Telangiectasia
Molecular Linkage Between the Kinase ATM and NF-{kappa}B Signaling in Response to Genotoxic Stimuli.
Ataxia Telangiectasia
Molecular Regulation of DNA Damage-Induced Apoptosis in Neurons of Cerebral Cortex.
Ataxia Telangiectasia
Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53.
Ataxia Telangiectasia
Molecular Testing Identifies Determinants of Exceptional Response and Guides Precision Therapy in a Patient with Lethal, Treatment-emergent Neuroendocrine Prostate Cancer.
Ataxia Telangiectasia
Monitoring and signaling of radiation-induced damage in mammalian cells.
Ataxia Telangiectasia
Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities.
Ataxia Telangiectasia
Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype.
Ataxia Telangiectasia
Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family.
Ataxia Telangiectasia
Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers.
Ataxia Telangiectasia
Motor pathway degeneration in young ataxia telangiectasia patients: A diffusion tractography study.
Ataxia Telangiectasia
Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy.
Ataxia Telangiectasia
MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.
Ataxia Telangiectasia
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
Ataxia Telangiectasia
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
Ataxia Telangiectasia
MRN complex is an essential effector of DNA damage repair.
Ataxia Telangiectasia
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Ataxia Telangiectasia
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1?.
Ataxia Telangiectasia
MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation.
Ataxia Telangiectasia
Multi-drugs resistant acne rosacea in a child affected by Ataxia-Telangiectasia: successful treatment with Isotretinoin.
Ataxia Telangiectasia
Multi-omics analysis of pathological changes in the amygdala of rats subjected to chronic restraint stress.
Ataxia Telangiectasia
Multidisciplinary Management of Ataxia Telangiectasia: Current Perspectives.
Ataxia Telangiectasia
Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy.
Ataxia Telangiectasia
Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance.
Ataxia Telangiectasia
Multiparametric cerebellar imaging and clinical phenotype in childhood ataxia telangiectasia.
Ataxia Telangiectasia
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.
Ataxia Telangiectasia
Multiple roles for MRE11 at uncapped telomeres.
Ataxia Telangiectasia
Multispectral imaging flow cytometry reveals distinct frequencies of ?-H2AX foci induction in DNA double strand break repair defective human cell lines.
Ataxia Telangiectasia
Multistage Vectored siRNA Targeting Ataxia-Telangiectasia Mutated for Breast Cancer Therapy.
Ataxia Telangiectasia
Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication.
Ataxia Telangiectasia
Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma.
Ataxia Telangiectasia
Mutant Single Nucleotide Polymorphism rs189037 in Ataxia-Telangiectasia Mutated Gene Is Significantly Associated With Ventricular Wall Thickness and Human Lifespan.
Ataxia Telangiectasia
Mutation analysis of multiple pilomatricomas in a patient with myotonic dystrophy type 1 suggests a DM1-associated hypermutation phenotype.
Ataxia Telangiectasia
Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma.
Ataxia Telangiectasia
Mutation at intronic repeats of the ataxia-telangiectasia mutated (ATM) gene and ATM protein loss in primary gastric cancer with microsatellite instability.
Ataxia Telangiectasia
Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.
Ataxia Telangiectasia
Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53.
Ataxia Telangiectasia
Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma.
Ataxia Telangiectasia
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.
Ataxia Telangiectasia
Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers.
Ataxia Telangiectasia
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.
Ataxia Telangiectasia
Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma.
Ataxia Telangiectasia
Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.
Ataxia Telangiectasia
MutL homolog 1 contributes to temozolomide-induced autophagy via ataxia-telangiectasia mutated in glioma.
Ataxia Telangiectasia
Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage.
Ataxia Telangiectasia
Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-?B pathways.
Ataxia Telangiectasia
Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C.
Ataxia Telangiectasia
MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii.
Ataxia Telangiectasia
N-Acetyl Cysteine as a Novel Polymethyl Methacrylate Resin Component: Protection against Cell Apoptosis and Genotoxicity.
Ataxia Telangiectasia
N-methyl-N'-nitro-N-nitrosoguanidine activates cell-cycle arrest through distinct mechanisms activated in a dose-dependent manner.
Ataxia Telangiectasia
NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.
Ataxia Telangiectasia
Nanotube-based colorimetric probe for ultrasensitive detection of ataxia telangiectasia mutated protein.
Ataxia Telangiectasia
Naturally occurring reoviruses for human cancer therapy.
Ataxia Telangiectasia
Nbn gene inactivation in the CNS of mouse inhibits the myelinating ability of the mature cortical oligodendrocytes.
Ataxia Telangiectasia
NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity.
Ataxia Telangiectasia
Nbs1 is required for ATR-dependent phosphorylation events.
Ataxia Telangiectasia
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-? Feedforward Signaling.
Ataxia Telangiectasia
Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons.
Ataxia Telangiectasia
Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis.
Ataxia Telangiectasia
New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress.
Ataxia Telangiectasia
New rationales for using TGFbeta inhibitors in radiotherapy.
Ataxia Telangiectasia
New Role of ATM in Controlling GABAergic Tone During Development.
Ataxia Telangiectasia
New tricks for an old fox: impact of TGF? on the DNA damage response and genomic stability.
Ataxia Telangiectasia
NF-?B Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress.
Ataxia Telangiectasia
NF-kappa B signaling pathway as a target for human tumor radiosensitization.
Ataxia Telangiectasia
NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin.
Ataxia Telangiectasia
Nickel carcinogenesis mechanism: cell cycle dysregulation.
Ataxia Telangiectasia
Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53.
Ataxia Telangiectasia
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
Ataxia Telangiectasia
NMR- and MD simulation-based structural characterization of the membrane-associating FATC domain of ataxia telangiectasia mutated.
Ataxia Telangiectasia
No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer.
Ataxia Telangiectasia
Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin.
Ataxia Telangiectasia
Nodal increases the malignancy of childhood neuroblastoma cells via regulation of Zeb1.
Ataxia Telangiectasia
Non-BRCA1/2 Breast Cancer Susceptibility Genes: A New Frontier with Clinical Consequences for Plastic Surgeons.
Ataxia Telangiectasia
Non-Hodgkin B-cell Lymphoma of the Ovary in a Child with Ataxia-Telangiectasia.
Ataxia Telangiectasia
Non-homologous end joining in class switch recombination: the beginning of the end.
Ataxia Telangiectasia
Non-homologous end joining pathway is the major route of protection against 4?-hydroxywithanolide E-induced DNA damage in MCF-7 cells.
Ataxia Telangiectasia
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks.
Ataxia Telangiectasia
Non-thermal DNA damage of cancer cells using near-infrared irradiation.
Ataxia Telangiectasia
Noncanonical ATM Activation and Signaling in Response to Transcription-Blocking DNA Damage.
Ataxia Telangiectasia
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Ataxia Telangiectasia
Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells.
Ataxia Telangiectasia
NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae.
Ataxia Telangiectasia
Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway.
Ataxia Telangiectasia
Novel and emerging drugs for rarer chronic lymphoid leukaemias.
Ataxia Telangiectasia
Novel ATM mutations with ataxia-telangiectasia.
Ataxia Telangiectasia
Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma.
Ataxia Telangiectasia
Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.
Ataxia Telangiectasia
Novel insights into the pathophysiology of chemotherapy-induced damage to the ovary.
Ataxia Telangiectasia
Novel pathway of centrosome amplification that does not require DNA lesions.
Ataxia Telangiectasia
Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway.
Ataxia Telangiectasia
Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGF? and ATM pathways.
Ataxia Telangiectasia
Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of DNA damage signaling.
Ataxia Telangiectasia
NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy.
Ataxia Telangiectasia
NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway.
Ataxia Telangiectasia
Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.
Ataxia Telangiectasia
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
Ataxia Telangiectasia
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells.
Ataxia Telangiectasia
Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells.
Ataxia Telangiectasia
Nuclear initiated NF-?B signaling: NEMO and ATM take center stage.
Ataxia Telangiectasia
Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.
Ataxia Telangiectasia
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
Ataxia Telangiectasia
Nuclear survivin and its relationship to DNA damage repair genes in non-small cell lung cancer investigated using tissue array.
Ataxia Telangiectasia
Nucleolar protein nucleolin functions in replication stress-induced DNA damage responses.
Ataxia Telangiectasia
Nucleolar stress induces a senescence-like phenotype in smooth muscle cells and promotes development of vascular degeneration.
Ataxia Telangiectasia
Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability.
Ataxia Telangiectasia
O-GlcNAc modification affects the ATM-mediated DNA damage response.
Ataxia Telangiectasia
Obesity alters the ovarian DNA damage response and apoptotic proteins.
Ataxia Telangiectasia
Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have progressed following first-line therapy (GOLD): a double-blind, randomised, placebo-controlled, phase 3 trial.
Ataxia Telangiectasia
Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response.
Ataxia Telangiectasia
Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma.
Ataxia Telangiectasia
On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response.
Ataxia Telangiectasia
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Ataxia Telangiectasia
Oncogenic events triggered by AID, the adverse effect of antibody diversification.
Ataxia Telangiectasia
Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer.
Ataxia Telangiectasia
Oncogenic WIP1 phosphatase attenuates the DNA damage response and sensitizes p53 mutant Jurkat cells to apoptosis.
Ataxia Telangiectasia
One-step site-directed mutagenesis of ATM cDNA in large (20kb) plasmid constructs.
Ataxia Telangiectasia
Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health.
Ataxia Telangiectasia
Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents.
Ataxia Telangiectasia
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Ataxia Telangiectasia
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.
Ataxia Telangiectasia
Orphan nuclear receptor SHP negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of STAT5 transactivation.
Ataxia Telangiectasia
Oscillatory dynamics of p53 genetic network induced by feedback loops and time delays.
Ataxia Telangiectasia
Osteolineage niche cells initiate hematopoietic stem cell mobilization.
Ataxia Telangiectasia
Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer.
Ataxia Telangiectasia
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.
Ataxia Telangiectasia
Overexpression of B-cell lymphoma 6 alters gene expression profile in a myeloma cell line and is associated with decreased DNA damage response.
Ataxia Telangiectasia
Overexpression of CDCA2 in Human Squamous Cell Carcinoma: Correlation with Prevention of G1 Phase Arrest and Apoptosis.
Ataxia Telangiectasia
Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits.
Ataxia Telangiectasia
Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer.
Ataxia Telangiectasia
Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis.
Ataxia Telangiectasia
Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction.
Ataxia Telangiectasia
Oxidative stress disassembles the p38/NPM/PP2A complex, which leads to modulation of nucleophosmin-mediated signaling to DNA damage response.
Ataxia Telangiectasia
Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.
Ataxia Telangiectasia
Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation.
Ataxia Telangiectasia
Oxidative stress induces apoptosis via calpain- and caspase-3-mediated cleavage of ATM in pancreatic acinar cells.
Ataxia Telangiectasia
Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice.
Ataxia Telangiectasia
p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.
Ataxia Telangiectasia
p27Kip1 Stabilization Is Essential for the Maintenance of Cell Cycle Arrest in Response to DNA Damage.
Ataxia Telangiectasia
p38? plays differential roles in hematopoietic stem cell activity dependent on aging contexts.
Ataxia Telangiectasia
P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance.
Ataxia Telangiectasia
p53 and ATM/ATR regulate 7,12-dimethylbenz[a]anthracene-induced immunosuppression.
Ataxia Telangiectasia
p53 as a retrovirus-induced oxidative stress modulator.
Ataxia Telangiectasia
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks.
Ataxia Telangiectasia
p53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.
Ataxia Telangiectasia
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.
Ataxia Telangiectasia
p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells.
Ataxia Telangiectasia
p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure.
Ataxia Telangiectasia
P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.
Ataxia Telangiectasia
p53-Independent Apoptosis Disrupts Early Organogenesis in Embryos Lacking Both Ataxia-Telangiectasia Mutated and Prkdc.
Ataxia Telangiectasia
p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.
Ataxia Telangiectasia
P65-mediated miR-590 inhibition modulates the chemoresistance of osteosarcoma to doxorubicin through targeting wild-type p53-induced phosphatase 1.
Ataxia Telangiectasia
PACS-2 mediates the ATM and NF-?B-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage.
Ataxia Telangiectasia
Papillary thyroid carcinoma in a 9-year-old girl with ataxia-telangiectasia.
Ataxia Telangiectasia
Parallel profiling of the transcriptome, cistrome, and epigenome in the cellular response to ionizing radiation.
Ataxia Telangiectasia
PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness.
Ataxia Telangiectasia
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Ataxia Telangiectasia
Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.
Ataxia Telangiectasia
Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated.
Ataxia Telangiectasia
Pathogenesis of mantle-cell lymphoma: all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways.
Ataxia Telangiectasia
Pathological neoangiogenesis depends on oxidative stress regulation by ATM.
Ataxia Telangiectasia
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
Ataxia Telangiectasia
Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways.
Ataxia Telangiectasia
Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.
Ataxia Telangiectasia
Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis.
Ataxia Telangiectasia
Persistence of DNA Double-Strand Breaks in Normal Human Cells Induced by Radiation-Induced Bystander Effect.
Ataxia Telangiectasia
Persistence of DNA double-strand breaks in normal human cells induced by radiation-induced bystander effect.
Ataxia Telangiectasia
Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-?B activation.
Ataxia Telangiectasia
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells.
Ataxia Telangiectasia
PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells.
Ataxia Telangiectasia
Pharmacologic manipulation of the ataxia-telangiectasia mutated gene product as an intervention in age-related disease.
Ataxia Telangiectasia
Pharmacological countermeasures for the acute radiation syndrome.
Ataxia Telangiectasia
Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.
Ataxia Telangiectasia
Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.
Ataxia Telangiectasia
Pharmacological targets and mechanisms of calycosin against meningitis.
Ataxia Telangiectasia
Pharmacology of the ATM inhibitor AZD0156: potentiation of irradiation and olaparib responses pre-clinically.
Ataxia Telangiectasia
Phase I Study of Ceralasertib (AZD6738), a Novel DNA Damage Repair Agent, in Combination with Weekly Paclitaxel in Refractory Cancer.
Ataxia Telangiectasia
Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response.
Ataxia Telangiectasia
Phenformin and ataxia-telangiectasia mutated inhibitors synergistically co-suppress liver cancer cell growth by damaging mitochondria.
Ataxia Telangiectasia
Phenotypic Analysis of ATM Protein Kinase in DNA Double-Strand Break Formation and Repair.
Ataxia Telangiectasia
Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.
Ataxia Telangiectasia
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
Ataxia Telangiectasia
Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas.
Ataxia Telangiectasia
Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line.
Ataxia Telangiectasia
Phospho-?Np63?-dependent regulation of autophagic signaling through transcription and micro-RNA modulation.
Ataxia Telangiectasia
Phospho-?Np63?/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells.
Ataxia Telangiectasia
Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.
Ataxia Telangiectasia
Phosphoglycerate mutase 1 (PGAM1) overexpression promotes radio- and chemoresistance in gliomas by activating the DNA damage response.
Ataxia Telangiectasia
Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress.
Ataxia Telangiectasia
Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition.
Ataxia Telangiectasia
Phosphorylated p63 induces transcription of regulatory particle non ATP-ase subunit 13 and nitric oxide synthase-2 protein degradation.
Ataxia Telangiectasia
Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function.
Ataxia Telangiectasia
Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.
Ataxia Telangiectasia
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Ataxia Telangiectasia
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
Ataxia Telangiectasia
Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes.
Ataxia Telangiectasia
Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.
Ataxia Telangiectasia
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage.
Ataxia Telangiectasia
Phosphorylation of Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A by Ataxia Telangiectasia Mutated and Rad3-Related-Dependent Checkpoint Pathway Promotes Cell Survival in Response to UV Irradiation.
Ataxia Telangiectasia
Phosphorylation of p300 by ATM controls the stability of NBS1.
Ataxia Telangiectasia
Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: involvement of ATM pathway.
Ataxia Telangiectasia
Phosphorylation of p53 protein in A549 human pulmonary epithelial cells exposed to asbestos fibers.
Ataxia Telangiectasia
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.
Ataxia Telangiectasia
Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis.
Ataxia Telangiectasia
Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.
Ataxia Telangiectasia
Phosphorylation of SRSF1 is modulated by replicational stress.
Ataxia Telangiectasia
PI3K-like kinases restrain Pim gene expression in endothelial cells.
Ataxia Telangiectasia
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Ataxia Telangiectasia
Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation.
Ataxia Telangiectasia
PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.
Ataxia Telangiectasia
Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation.
Ataxia Telangiectasia
Plant ?H2AX foci are required for proper DNA DSB repair responses and colocalize with E2F factors.
Ataxia Telangiectasia
PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening.
Ataxia Telangiectasia
Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest.
Ataxia Telangiectasia
Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase.
Ataxia Telangiectasia
Poly(ADP-ribosyl)ation affects stabilization of Che-1 protein in response to DNA damage.
Ataxia Telangiectasia
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.
Ataxia Telangiectasia
Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells.
Ataxia Telangiectasia
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Ataxia Telangiectasia
Polymorphism rs1801516 (G?>?A) in the ATM gene is not associated with overall cancer risk: an updated meta-analysis.
Ataxia Telangiectasia
Polymorphism rs189037C > T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: a case control study.
Ataxia Telangiectasia
Polyomavirus interaction with the DNA damage response.
Ataxia Telangiectasia
Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types.
Ataxia Telangiectasia
Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts.
Ataxia Telangiectasia
Post-Breast Cancer Radiotherapy Bronchiolitis Obliterans Organizing Pneumonia.
Ataxia Telangiectasia
Post-Translational Regulation of the RSF1 Chromatin Remodeler under DNA Damage.
Ataxia Telangiectasia
Potency and property of DNA conformational damage determine ATM activation: two new DNA topological probes.
Ataxia Telangiectasia
Potent Activity of Composite Cyclin Dependent Kinase Inhibition against Hepatocellular Carcinoma.
Ataxia Telangiectasia
Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells.
Ataxia Telangiectasia
Potential role of ATM in hepatocyte endocytosis of ApoE-deficient, ApoB48-containing lipoprotein in ApoE-deficient mice.
Ataxia Telangiectasia
Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.
Ataxia Telangiectasia
PP2A Regulates Phosphorylation-Dependent Isomerization of Cytoplasmic and Mitochondrial-Associated ATR by Pin1 in DNA Damage Responses.
Ataxia Telangiectasia
PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.
Ataxia Telangiectasia
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase.
Ataxia Telangiectasia
Pravastatin reduces radiation-induced damage in normal tissues.
Ataxia Telangiectasia
Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers.
Ataxia Telangiectasia
Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019.
Ataxia Telangiectasia
Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors.
Ataxia Telangiectasia
Pretreatment of Small-for-Size Grafts In Vivo by ? -Aminobutyric Acid Receptor Regulation against Oxidative Stress-Induced Injury in Rat Split Orthotopic Liver Transplantation.
Ataxia Telangiectasia
Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells.
Ataxia Telangiectasia
Prevalence of ATM Sequence Variants in Northern Plains American Indian Cancer Patients.
Ataxia Telangiectasia
Prevention of thymic lymphoma development in Atm-/- mice by dexamethasone.
Ataxia Telangiectasia
Primary immunodeficiency syndromes associated with defective DNA double-strand break repair.
Ataxia Telangiectasia
Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts.
Ataxia Telangiectasia
Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
Ataxia Telangiectasia
Prognostic relevance of ATM protein in uveal melanoma and its association with clinicopathological factors.
Ataxia Telangiectasia
Prognostic relevance of DNA damage and repair biomarkers in elderly patients with hormone-receptor-positive breast cancer treated with neoadjuvant hormone therapy: evidence from the real-world setting.
Ataxia Telangiectasia
Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer.
Ataxia Telangiectasia
Prognostic significance of ATM and cyclin B1 in pancreatic neuroendocrine tumor.
Ataxia Telangiectasia
Prognostic significance of G2/M arrest signaling pathway proteins in advanced non-small cell lung cancer patients.
Ataxia Telangiectasia
Prognostic Significance of Nuclear Phospho-ATM Expression in Melanoma.
Ataxia Telangiectasia
Programmed cell death may act as a surveillance mechanism to safeguard male gametophyte development in Arabidopsis.
Ataxia Telangiectasia
Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells.
Ataxia Telangiectasia
Programmed phosphorylation of histone H2AX precedes a phase of DNA double-strand break-independent synapsis in mouse meiosis.
Ataxia Telangiectasia
Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response.
Ataxia Telangiectasia
Promoter Hypermethylation of the ATM Gene as a Novel Biomarker for Breast Cancer
Ataxia Telangiectasia
Promotion of DNA repair by nuclear IKK? phosphorylation of ATM in response to genotoxic stimuli.
Ataxia Telangiectasia
Prostate cancer is known by the companionship with ATM and miRNA it keeps: craftsmen of translation have dual behaviour with tailors of life thread.
Ataxia Telangiectasia
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Ataxia Telangiectasia
Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks.
Ataxia Telangiectasia
Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.
Ataxia Telangiectasia
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Ataxia Telangiectasia
Protective effects of ginsenoside Rg2 and astaxanthin mixture against UVB-induced DNA damage.
Ataxia Telangiectasia
Protective effects of Korean red ginseng against radiation-induced apoptosis in human HaCaT keratinocytes.
Ataxia Telangiectasia
Protective effects of SND1 in retinal photoreceptor cell damage induced by ionizing radiation.
Ataxia Telangiectasia
Protective mechanism of morin against ultraviolet B-induced cellular senescence in human keratinocyte stem cells.
Ataxia Telangiectasia
Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.
Ataxia Telangiectasia
Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs.
Ataxia Telangiectasia
Protein phosphatase 1? is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage.
Ataxia Telangiectasia
Protein Phosphatase 2A Antagonizes ATM and ATR in a Cdk2- and Cdc7-Independent DNA Damage Checkpoint.
Ataxia Telangiectasia
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.
Ataxia Telangiectasia
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination.
Ataxia Telangiectasia
Proteome-wide Detection and Quantitative Analysis of Irreversible Cysteine Oxidation Using Long Column UPLC-pSRM.
Ataxia Telangiectasia
Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity.
Ataxia Telangiectasia
Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling.
Ataxia Telangiectasia
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
Ataxia Telangiectasia
Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent manner.
Ataxia Telangiectasia
PTEN enhances G2/M arrest in etoposide-treated MCF?7 cells through activation of the ATM pathway.
Ataxia Telangiectasia
PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.
Ataxia Telangiectasia
PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer.
Ataxia Telangiectasia
Punicalagin from pomegranate promotes human papillary thyroid carcinoma BCPAP cell death by triggering ATM-mediated DNA damage response.
Ataxia Telangiectasia
Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1.
Ataxia Telangiectasia
Purkinje Cell Degeneration in pcd Mice Reveals Large Scale Chromatin Reorganization and Gene Silencing Linked to Defective DNA Repair.
Ataxia Telangiectasia
Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.
Ataxia Telangiectasia
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ataxia Telangiectasia
Qualitative and quantitative analysis of phosphorylated ATM foci induced by low-dose ionizing radiation.
Ataxia Telangiectasia
Quantification of gammaH2AX foci in response to ionising radiation.
Ataxia Telangiectasia
Quantitation of gammaH2AX foci in tissue samples.
Ataxia Telangiectasia
Quantitative and Dynamic Imaging of ATM Kinase Activity by Bioluminescence Imaging.
Ataxia Telangiectasia
Quantitative and Dynamic Imaging of ATM Kinase Activity.
Ataxia Telangiectasia
Quantitative Mass Spectrometry by Isotope Dilution and Multiple Reaction Monitoring (MRM).
Ataxia Telangiectasia
Quantitative mRNA expression analysis of selected genes in patients with early-stage hypothyroidism induced by treatment with iodine-131.
Ataxia Telangiectasia
Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response.
Ataxia Telangiectasia
Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73.
Ataxia Telangiectasia
r-Tocotrienol inhibits cell proliferation of human gastric cancer by regulating nuclear factor-kB activity.
Ataxia Telangiectasia
RAC1 GTPase plays an important role in ?-irradiation induced G2/M checkpoint activation.
Ataxia Telangiectasia
Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.
Ataxia Telangiectasia
Racial Disparities in the Molecular Landscape of Cancer.
Ataxia Telangiectasia
Rad50 depletion impacts upon ATR-dependent DNA damage responses.
Ataxia Telangiectasia
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.
Ataxia Telangiectasia
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
Ataxia Telangiectasia
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation.
Ataxia Telangiectasia
Radiation, DNA damage and cancer.
Ataxia Telangiectasia
Radiation-induced cell signaling: inside-out and outside-in.
Ataxia Telangiectasia
Radiation-induced DNA damage and repair effects on 3D genome organization.
Ataxia Telangiectasia
Radiation-Induced DNA Damage in Operators Performing Endovascular Aortic Repair.
Ataxia Telangiectasia
Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase.
Ataxia Telangiectasia
Radiological Imaging in Ataxia Telangiectasia: a Review.
Ataxia Telangiectasia
Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors.
Ataxia Telangiectasia
Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein.
Ataxia Telangiectasia
Radiosensitization of the PI3K inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer.
Ataxia Telangiectasia
Radiosensitization of tumor cells by modulation of ATM kinase.
Ataxia Telangiectasia
Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells.
Ataxia Telangiectasia
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1?.
Ataxia Telangiectasia
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Ataxia Telangiectasia
Radiotherapy induces cell cycle arrest and cell apoptosis in nasopharyngeal carcinoma via the ATM and Smad pathways.
Ataxia Telangiectasia
Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-?B activation.
Ataxia Telangiectasia
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
Ataxia Telangiectasia
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.
Ataxia Telangiectasia
Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer.
Ataxia Telangiectasia
RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205.
Ataxia Telangiectasia
Rapid and efficient ATM mutation detection by fluorescent chemical cleavage of mismatch: identification of four novel mutations.
Ataxia Telangiectasia
Rapid and Progressive Pulmonary Fibrosis in 2 Families with DNA Repair Deficiencies of Undetermined Etiology.
Ataxia Telangiectasia
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Ataxia Telangiectasia
Rapid screen for truncating ATM mutations by PTT-ELISA.
Ataxia Telangiectasia
Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer.
Ataxia Telangiectasia
Rare variants in the ATM gene and risk of breast cancer.
Ataxia Telangiectasia
Ras induces chromosome instability and abrogation of the DNA damage response.
Ataxia Telangiectasia
Rational Design of 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor.
Ataxia Telangiectasia
Reactivation of Epstein-Barr Virus by HIF-1? Requires p53.
Ataxia Telangiectasia
Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen.
Ataxia Telangiectasia
Reactive oxygen species abrogate the anticarcinogenic effect of eicosapentaenoic acid in Atm-deficient mice.
Ataxia Telangiectasia
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification.
Ataxia Telangiectasia
Recent advances in the study of immunodeficiency and DNA damage response.
Ataxia Telangiectasia
Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications.
Ataxia Telangiectasia
Recently emerging signaling landscape of ataxia-telangiectasia mutated (ATM) kinase.
Ataxia Telangiectasia
Receptor Tyrosine Kinase EphA5 is a Functional Molecular Target in Human Lung Cancer.
Ataxia Telangiectasia
Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance.
Ataxia Telangiectasia
Recombinational DNA repair and human disease.
Ataxia Telangiectasia
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Ataxia Telangiectasia
Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection.
Ataxia Telangiectasia
Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling.
Ataxia Telangiectasia
Redox homeostasis: the linchpin in stem cell self-renewal and differentiation.
Ataxia Telangiectasia
Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance.
Ataxia Telangiectasia
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Ataxia Telangiectasia
Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein.
Ataxia Telangiectasia
Redundant and nonredundant functions of ATM and H2AX in ?? T-lineage lymphocytes.
Ataxia Telangiectasia
Regulation and localization of the Bloom syndrome protein in response to DNA damage.
Ataxia Telangiectasia
Regulation and mechanisms of mammalian double-strand break repair.
Ataxia Telangiectasia
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Ataxia Telangiectasia
Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1.
Ataxia Telangiectasia
Regulation of ATR-dependent DNA damage response by nitric oxide.
Ataxia Telangiectasia
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.
Ataxia Telangiectasia
Regulation of DNA Damage Response by Estrogen Receptor ?-Mediated Inhibition of Breast Cancer Associated Gene 2.
Ataxia Telangiectasia
Regulation of DNA replication by the S-phase DNA damage checkpoint.
Ataxia Telangiectasia
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4.
Ataxia Telangiectasia
Regulation of human pol? by ATM-mediated phosphorylation during non-homologous end joining.
Ataxia Telangiectasia
Regulation of ionizing radiation-induced adhesion of breast cancer cells to fibronectin by alpha5beta1 integrin.
Ataxia Telangiectasia
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling.
Ataxia Telangiectasia
Regulation of oxidative stress responses by ataxia-telangiectasia mutated is required for T cell proliferation.
Ataxia Telangiectasia
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.
Ataxia Telangiectasia
Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.
Ataxia Telangiectasia
Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting.
Ataxia Telangiectasia
Regulation of TIP60 by ATF2 modulates ATM activation.
Ataxia Telangiectasia
Rejuvenating Bi(d)ology.
Ataxia Telangiectasia
Rejuvenating the immune system in rheumatoid arthritis.
Ataxia Telangiectasia
Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1.
Ataxia Telangiectasia
Relationships of FOXE1 and ATM genetic polymorphisms with papillary thyroid carcinoma risk: a meta-analysis.
Ataxia Telangiectasia
Remarkable response to a novel ATR inhibitor in a patient with poorly differentiated neuroendocrine carcinoma.
Ataxia Telangiectasia
Repair of Chromosomal RAG-Mediated DNA Breaks by Mutant RAG Proteins Lacking Phosphatidylinositol 3-Like Kinase Consensus Phosphorylation Sites.
Ataxia Telangiectasia
Repair of DNA Damage Induced by the Cytidine Analog Zebularine Requires ATR and ATM in Arabidopsis.
Ataxia Telangiectasia
Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence.
Ataxia Telangiectasia
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.
Ataxia Telangiectasia
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
Ataxia Telangiectasia
Requirement for DNA ligase IV during embryonic neuronal development.
Ataxia Telangiectasia
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Ataxia Telangiectasia
Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.
Ataxia Telangiectasia
Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.
Ataxia Telangiectasia
Resistance against Friend leukemia virus-induced leukemogenesis in DNA-dependent protein kinase (DNA-PK)-deficient scid mice associated with defective viral integration at the Spi-1 and Fli-1 site.
Ataxia Telangiectasia
Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.
Ataxia Telangiectasia
Resveratrol activates DNA damage response through inhibition of polo-like kinase 1 (PLK1) in natural killer/T cell lymphoma.
Ataxia Telangiectasia
Resveratrol ameliorates high-fat diet-induced insulin resistance and fatty acid oxidation via ATM-AMPK axis in skeletal muscle.
Ataxia Telangiectasia
Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces G?/M cell cycle arrest through the activation of ATM/ATR in human cervical carcinoma HeLa cells.
Ataxia Telangiectasia
Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis.
Ataxia Telangiectasia
Retinoic Acid-related Orphan Receptor-? Is Induced in the Setting of DNA Damage and Promotes Pulmonary Emphysema.
Ataxia Telangiectasia
Revealing determinants of two-phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model.
Ataxia Telangiectasia
Revisiting p53 for cancer-specific chemo- and radiotherapy: Ten years after.
Ataxia Telangiectasia
Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway.
Ataxia Telangiectasia
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Ataxia Telangiectasia
Riluzole Enhances the Response of Human Nasopharyngeal Carcinoma Cells to Ionizing Radiation via ATM/P53 Signalling Pathway.
Ataxia Telangiectasia
Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us.
Ataxia Telangiectasia
RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells.
Ataxia Telangiectasia
RNF8 plays an important role in the radioresistance of human nasopharyngeal cancer cells in vitro.
Ataxia Telangiectasia
RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells.
Ataxia Telangiectasia
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression.
Ataxia Telangiectasia
Role for p53 in selenium-induced senescence.
Ataxia Telangiectasia
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.
Ataxia Telangiectasia
Role of ataxia telangiectasia mutated in insulin signalling of muscle-derived cell lines and mouse soleus.
Ataxia Telangiectasia
Role of ataxia-telangiectasia mutated (ATM) in porcine oocyte in vitro maturation.
Ataxia Telangiectasia
Role of ataxia-telangiectasia mutated in hydrogen peroxide preconditioning against oxidative stress in Neuro-2a cells.
Ataxia Telangiectasia
Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.
Ataxia Telangiectasia
Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death.
Ataxia Telangiectasia
Role of CHK2 in cancer development.
Ataxia Telangiectasia
Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia.
Ataxia Telangiectasia
Role of DNA damage in the progress of chronic tubule?interstitial injury.
Ataxia Telangiectasia
Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review.
Ataxia Telangiectasia
Role of GLUT1 in regulation of reactive oxygen species.
Ataxia Telangiectasia
Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53.
Ataxia Telangiectasia
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.
Ataxia Telangiectasia
Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus.
Ataxia Telangiectasia
Role of p53 and ATM in photodynamic therapy-induced apoptosis.
Ataxia Telangiectasia
Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells.
Ataxia Telangiectasia
Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.
Ataxia Telangiectasia
Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases.
Ataxia Telangiectasia
Role of the translationally controlled tumor protein in DNA damage sensing and repair.
Ataxia Telangiectasia
Role of wild-type p53-induced phosphatase 1 in cancer.
Ataxia Telangiectasia
Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair.
Ataxia Telangiectasia
Roles of ATM and ATR-Mediated DNA Damage Responses during Lytic BK Polyomavirus Infection.
Ataxia Telangiectasia
Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response.
Ataxia Telangiectasia
Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis.
Ataxia Telangiectasia
Rotavirus activates a noncanonical ATM-Chk2 branch of DNA damage response during infection to positively regulate viroplasm dynamics.
Ataxia Telangiectasia
Rotundic acid enhances the impact of radiological toxicity on MCF-7 cells through the ATM/p53 pathway.
Ataxia Telangiectasia
Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest.
Ataxia Telangiectasia
RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana.
Ataxia Telangiectasia
RUG3 is a negative regulator of plant responses to ABA in Arabidopsis thaliana.
Ataxia Telangiectasia
S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells.
Ataxia Telangiectasia
SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in Arabidopsis.
Ataxia Telangiectasia
Scorpins in the DNA Damage Response.
Ataxia Telangiectasia
Screening breast cancer patients for Norwegian ATM mutations.
Ataxia Telangiectasia
Screening for ATM sequence alterations in African-American women diagnosed with breast cancer.
Ataxia Telangiectasia
Screening of gene mutations associated with bone metastasis in nonsmall cell lung cancer.
Ataxia Telangiectasia
Section 1. Antibiotics and Chemotherapeutics Apigenin induces DNA damage through the PKC?-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.
Ataxia Telangiectasia
Selection-subtraction approach (SSA): a universal genetic screening technique that enables negative selection.
Ataxia Telangiectasia
Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage.
Ataxia Telangiectasia
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine.
Ataxia Telangiectasia
Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development.
Ataxia Telangiectasia
Selenium compounds activate early barriers of tumorigenesis.
Ataxia Telangiectasia
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
Ataxia Telangiectasia
Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics.
Ataxia Telangiectasia
Sensing of intermediates in V(D)J recombination by ATM.
Ataxia Telangiectasia
Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin.
Ataxia Telangiectasia
Sensors and Inhibitors for the Detection of Ataxia Telangiectasia Mutated (ATM) Protein Kinase.
Ataxia Telangiectasia
Ser-Gln sites of SOG1 are rapidly hyperphosphorylated in response to DNA double-strand breaks.
Ataxia Telangiectasia
Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.
Ataxia Telangiectasia
Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions.
Ataxia Telangiectasia
Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells.
Ataxia Telangiectasia
Severe radiotoxicity in an allogeneic transplant recipient with a heterozygous ATM mutation.
Ataxia Telangiectasia
Sharpening the ends for repair: mechanisms and regulation of DNA resection.
Ataxia Telangiectasia
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
Ataxia Telangiectasia
SHP-1 overexpression increases the radioresistance of NPC cells by enhancing DSB repair, increasing S phase arrest and decreasing cell apoptosis.
Ataxia Telangiectasia
Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells.
Ataxia Telangiectasia
Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response.
Ataxia Telangiectasia
Significance of ATM Gene Polymorphisms in Chronic Myeloid Leukemia - a Case Control Study from India.
Ataxia Telangiectasia
Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation.
Ataxia Telangiectasia
Silencing of ataxia-telangiectasia mutated by siRNA enhances the in vitro and in vivo radiosensitivity of glioma.
Ataxia Telangiectasia
Silencing of ATM expression by siRNA technique contributes to glioma stem cell radiosensitivity in vitro and in vivo.
Ataxia Telangiectasia
Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells.
Ataxia Telangiectasia
Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.
Ataxia Telangiectasia
Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase.
Ataxia Telangiectasia
Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks.
Ataxia Telangiectasia
Single nucleotide polymorphism in ATM gene, cooking oil fumes and lung adenocarcinoma susceptibility in Chinese female non-smokers: a case-control study.
Ataxia Telangiectasia
Single nucleotide polymorphisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma.
Ataxia Telangiectasia
Single-nucleotide polymorphisms of TGF?1 and ATM associated with radiation-induced pneumonitis: a prospective cohort study of thoracic cancer patients in China.
Ataxia Telangiectasia
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
Ataxia Telangiectasia
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Ataxia Telangiectasia
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
Ataxia Telangiectasia
SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair.
Ataxia Telangiectasia
SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress.
Ataxia Telangiectasia
SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.
Ataxia Telangiectasia
Six Novel ATM Gene Variants in Sri Lankan Patients with Ataxia Telangiectasia.
Ataxia Telangiectasia
SLC22A1 And ATM Genes Polymorphisms Are Associated With The Risk Of Type 2 Diabetes Mellitus In Western Saudi Arabia: A Case-Control Study.
Ataxia Telangiectasia
Small molecule 2,3-DCPE induces S phase arrest by activating the ATM/ATR-Chk1-Cdc25A signaling pathway in DLD-1 colon cancer cells.
Ataxia Telangiectasia
SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.
Ataxia Telangiectasia
Sodium glycididazole enhances the radiosensitivity of laryngeal cancer cells through downregulation of ATM signaling pathway.
Ataxia Telangiectasia
Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses.
Ataxia Telangiectasia
Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.
Ataxia Telangiectasia
Sophoridinol derivative 05D induces tumor cells apoptosis by topoisomerase1-mediated DNA breakage.
Ataxia Telangiectasia
Soy-derived isoflavones inhibit the growth of adult T-cell leukemia cells in vitro and in vivo.
Ataxia Telangiectasia
Sp1 Facilitates DNA Double-Strand Break Repair through a Nontranscriptional Mechanism.
Ataxia Telangiectasia
Special AT-rich sequence binding protein 1 expression correlates with response to preoperative radiotherapy and clinical outcome in rectal cancer.
Ataxia Telangiectasia
Speckle-type POZ protein, SPOP, is involved in the DNA damage response.
Ataxia Telangiectasia
Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.
Ataxia Telangiectasia
Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans.
Ataxia Telangiectasia
Squalene Inhibits ATM-Dependent Signaling in ?IR-Induced DNA Damage Response through Induction of Wip1 Phosphatase.
Ataxia Telangiectasia
Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.
Ataxia Telangiectasia
Statistical Analysis of ATM-Dependent Signaling in Quantitative Mass Spectrometry Phosphoproteomics.
Ataxia Telangiectasia
Stemness factor Sall4 is required for DNA damage response in embryonic stem cells.
Ataxia Telangiectasia
STING (or SRC) Like an ICB: Priming the Immune Response in Pancreatic Cancer.
Ataxia Telangiectasia
Strain background determines lymphoma incidence in atm knockout mice.
Ataxia Telangiectasia
Strategy to induce apoptosis and circumvent resistance in chronic lymphocytic leukaemia.
Ataxia Telangiectasia
Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells.
Ataxia Telangiectasia
Stress granules inhibit apoptosis by reducing reactive oxygen species production.
Ataxia Telangiectasia
Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp.
Ataxia Telangiectasia
Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response.
Ataxia Telangiectasia
Structural basis for multifunctional roles of human Ints3 C-terminal domain.
Ataxia Telangiectasia
Structure of the human dimeric ATM kinase.
Ataxia Telangiectasia
Structure of the intact ATM/Tel1 kinase.
Ataxia Telangiectasia
Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18.
Ataxia Telangiectasia
Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS).
Ataxia Telangiectasia
Substrate specificities and identification of putative substrates of ATM kinase family members.
Ataxia Telangiectasia
Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells.
Ataxia Telangiectasia
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.
Ataxia Telangiectasia
Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation.
Ataxia Telangiectasia
Suppression of the radiation-sensitive phenotype of hamster irs1 and irs2 strains selected for resistance to 3-aminobenzamide.
Ataxia Telangiectasia
Survival and Functional Immune Reconstitution After Haploidentical Stem Cell Transplantation in Atm-Deficient Mice.
Ataxia Telangiectasia
Susceptibility of ATM-deficient pancreatic cancer cells to radiation.
Ataxia Telangiectasia
Synaptic activity bidirectionally regulates a novel sequence-specific S-Q phosphoproteome in neurons.
Ataxia Telangiectasia
Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models.
Ataxia Telangiectasia
Synergistic effects of a novel lipid-soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway.
Ataxia Telangiectasia
Synergistic enhancement of NK cell-mediated cytotoxicity by combination of histone deacetylase inhibitor and ionizing radiation.
Ataxia Telangiectasia
Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway.
Ataxia Telangiectasia
Synthetically Lethal Interactions of ATM, ATR, and DNA-PKcs.
Ataxia Telangiectasia
T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23).
Ataxia Telangiectasia
T-cell prolymphocytic leukemia with der(11)t(1;11)(q21;q23) and ATM deficiency.
Ataxia Telangiectasia
T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.
Ataxia Telangiectasia
TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition.
Ataxia Telangiectasia
Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.
Ataxia Telangiectasia
Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways.
Ataxia Telangiectasia
Take a break--resveratrol in action on DNA.
Ataxia Telangiectasia
Take your PIKK: tumour viruses and DNA damage response pathways.
Ataxia Telangiectasia
Taming Tricky DSBs: ATM on duty.
Ataxia Telangiectasia
Tannic Acid Induces the Mitochondrial Pathway of Apoptosis and S Phase Arrest in Porcine Intestinal IPEC-J2 Cells.
Ataxia Telangiectasia
TAO kinases mediate activation of p38 in response to DNA damage.
Ataxia Telangiectasia
Targeted cancer therapies based on the inhibition of DNA strand break repair.
Ataxia Telangiectasia
Targeted disruption of Ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer.
Ataxia Telangiectasia
Targeted integration of functional human ATM cDNA into genome mediated by HSV/AAV hybrid amplicon vector.
Ataxia Telangiectasia
Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival.
Ataxia Telangiectasia
Targeted next generation sequencing identified a high frequency genetic mutated profile in wood smoke exposure-related lung adenocarcinoma patients.
Ataxia Telangiectasia
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity.
Ataxia Telangiectasia
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.
Ataxia Telangiectasia
Targeting Angiogenesis by Blocking the ATM-SerRS-VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma Growth.
Ataxia Telangiectasia
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.
Ataxia Telangiectasia
Targeting ATR in cancer medicine.
Ataxia Telangiectasia
Targeting breast cancer stem-like cells using chloroquine encapsulated by a triphenylphosphonium-functionalized hyperbranched polymer.
Ataxia Telangiectasia
Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma.
Ataxia Telangiectasia
Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219.
Ataxia Telangiectasia
Targeting NPRL2 to enhance the efficacy of Olaparib in castration-resistant prostate cancer.
Ataxia Telangiectasia
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection.
Ataxia Telangiectasia
Targeting phosphoinositide 3-kinase: moving towards therapy.
Ataxia Telangiectasia
Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates ?-histone 2AX (?-H2AX) levels upon ionizing radiation.
Ataxia Telangiectasia
Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells.
Ataxia Telangiectasia
Targeting the Ataxia Telangiectasia Mutated protein in cancer therapy.
Ataxia Telangiectasia
Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants.
Ataxia Telangiectasia
Targeting the ATR-CHK1 Axis in Cancer Therapy.
Ataxia Telangiectasia
Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death.
Ataxia Telangiectasia
Tel2 regulates the stability of PI3K-related protein kinases.
Ataxia Telangiectasia
Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner.
Ataxia Telangiectasia
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism.
Ataxia Telangiectasia
Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery.
Ataxia Telangiectasia
Telomere and ATM dynamics in CD4 T cell depletion in active and virus-suppressed HIV infection.
Ataxia Telangiectasia
Telomere capping and cellular checkpoints: clues from fruit flies.
Ataxia Telangiectasia
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Ataxia Telangiectasia
Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging.
Ataxia Telangiectasia
Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Ataxia Telangiectasia
Telomere dysfunction, autoimmunity and aging.
Ataxia Telangiectasia
Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: mechanism and therapeutic potential.
Ataxia Telangiectasia
Telomere Repeat-Binding Factor 2 Is Responsible for the Telomere Attachment to the Nuclear Membrane.
Ataxia Telangiectasia
Telomeres, histone code, and DNA damage response.
Ataxia Telangiectasia
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells.
Ataxia Telangiectasia
Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis.
Ataxia Telangiectasia
Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms.
Ataxia Telangiectasia
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).
Ataxia Telangiectasia
Tetrandrine Enhances H2O2-Induced Apoptotic Cell Death Through Caspase-dependent Pathway in Human Keratinocytes.
Ataxia Telangiectasia
The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses.
Ataxia Telangiectasia
The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.
Ataxia Telangiectasia
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.
Ataxia Telangiectasia
The antioxidant butylated hydroxyanisole potentiates the toxic effects of propylparaben in cultured mammalian cells.
Ataxia Telangiectasia
The antiproliferative effects of ataxia-telangiectasia mutated and ATM- and Rad3-related inhibitions and their enhancements with the cytotoxicity of DNA damaging agents in cholangiocarcinoma cells.
Ataxia Telangiectasia
The Arabidopsis MERISTEM DISORGANIZATION1 gene is required for maintenance of stem cells through reduction of the DNA damage level.
Ataxia Telangiectasia
The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species.
Ataxia Telangiectasia
The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response.
Ataxia Telangiectasia
The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study.
Ataxia Telangiectasia
The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCR? and IgH allelic exclusion.
Ataxia Telangiectasia
The Ataxia Telangiectasia mutated kinase controls Ig? allelic exclusion by inhibiting secondary V?-to-J? rearrangements.
Ataxia Telangiectasia
The Ataxia Telangiectasia Mutated Kinase Pathway Regulates IL-23 Expression by Human Dendritic Cells.
Ataxia Telangiectasia
The Ataxia-telangiectasia mutated gene and breast cancer: gene expression profiles and sequence variants.
Ataxia Telangiectasia
The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.
Ataxia Telangiectasia
The ATM Gene in Breast Cancer: Its Relevance in Clinical Practice.
Ataxia Telangiectasia
The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect.
Ataxia Telangiectasia
The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a ?H2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D.
Ataxia Telangiectasia
The ATM kinase signaling induced by the low-energy ?-particles emitted by (33)P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic ?-particles emitted by (32)P.
Ataxia Telangiectasia
The ATM protein kinase and cellular redox signaling: beyond the DNA damage response.
Ataxia Telangiectasia
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
Ataxia Telangiectasia
The ATM protein: The importance of being active.
Ataxia Telangiectasia
The ATM rs189037 G>A polymorphism is associated with the risk and prognosis of gastric cancer in Chinese individuals: A case-control study.
Ataxia Telangiectasia
The ATM signaling network in development and disease.
Ataxia Telangiectasia
The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation.
Ataxia Telangiectasia
The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.
Ataxia Telangiectasia
The ATM-dependent DNA damage response acts as an upstream trigger for compensation in the fas1 mutation during Arabidopsis leaf development.
Ataxia Telangiectasia
The ATM-mediated DNA-damage response: taking shape.
Ataxia Telangiectasia
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis.
Ataxia Telangiectasia
The ATM-SMC1 pathway is essential for activation of the chromium[VI]-induced S-phase checkpoint.
Ataxia Telangiectasia
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.
Ataxia Telangiectasia
The C Allele of ATM rs11212617 Associates With Higher Pathological Complete Remission Rate in Breast Cancer Patients Treated With Neoadjuvant Metformin.
Ataxia Telangiectasia
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
Ataxia Telangiectasia
The catalytic subunit of DNA-dependent protein kinase is downstream of ATM and feeds forward oxidative stress in the selenium-induced senescence response.
Ataxia Telangiectasia
The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair.
Ataxia Telangiectasia
The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage.
Ataxia Telangiectasia
The checkpoint kinase ATM protects against stress-induced elevation of cyclin D1 and potential cell death in neurons.
Ataxia Telangiectasia
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin.
Ataxia Telangiectasia
The Crucial Role of Cyclin-Dependent Kinase-5-Ataxia-Telangiectasia Mutated Axis in ICH-Induced Neuronal Injury of Rat Model.
Ataxia Telangiectasia
The CXXC finger 5 protein is required for DNA damage-induced p53 activation.
Ataxia Telangiectasia
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.
Ataxia Telangiectasia
The depletion of ATM inhibits colon cancer proliferation and migration via B56?2-mediated Chk1/p53/CD44 cascades.
Ataxia Telangiectasia
The development of ataxia telangiectasia mutated kinase inhibitors.
Ataxia Telangiectasia
The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease.
Ataxia Telangiectasia
The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.
Ataxia Telangiectasia
The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?
Ataxia Telangiectasia
The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.
Ataxia Telangiectasia
The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation.
Ataxia Telangiectasia
The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.
Ataxia Telangiectasia
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Ataxia Telangiectasia
The DNA repair protein ATM as a target in autism spectrum disorder.
Ataxia Telangiectasia
The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development.
Ataxia Telangiectasia
The effect of ataxia-telangiectasia mutated kinase-dependent hyperphosphorylation of checkpoint kinase-2 on oligodeoxynucleotide 7909 containing CpG motifs-enhanced sensitivity to X-rays in human lung adenocarcinoma A549 cells.
Ataxia Telangiectasia
The effect of ATM kinase inhibition on the initial response of human dental pulp and periodontal ligament mesenchymal stem cells to ionizing radiation.
Ataxia Telangiectasia
The efficacy and toxicity of ATM inhibition in glioblastoma initiating cells-driven tumor models.
Ataxia Telangiectasia
The expression of genes related to adipocyte differentiation in pigs.
Ataxia Telangiectasia
The Fission Yeast Rad32(Mre11)-Rad50-Nbs1 Complex Acts Both Upstream and Downstream of Checkpoint Signaling in the S-Phase DNA Damage Checkpoint.
Ataxia Telangiectasia
The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment.
Ataxia Telangiectasia
The Future of Radiobiology.
Ataxia Telangiectasia
The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy.
Ataxia Telangiectasia
The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells.
Ataxia Telangiectasia
The Hammer and the Dance of Cell Cycle Control.
Ataxia Telangiectasia
The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.
Ataxia Telangiectasia
The Herpesvirus Nuclear Egress Complex Component, UL31, Can Be Recruited to Sites of DNA Damage Through Poly-ADP Ribose Binding.
Ataxia Telangiectasia
The heterochromatic barrier to DNA double strand break repair: how to get the entry visa.
Ataxia Telangiectasia
The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks.
Ataxia Telangiectasia
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
Ataxia Telangiectasia
The impact of oxidative DNA changes and ATM expression on morphological and functional activities on hepatocytes obtained from mesenchymal stem cells.
Ataxia Telangiectasia
The Impact of p53 Dysfunction in ATR Inhibitor Cytotoxicity and Chemo- and Radiosensitisation.
Ataxia Telangiectasia
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2.
Ataxia Telangiectasia
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.
Ataxia Telangiectasia
The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells.
Ataxia Telangiectasia
The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.
Ataxia Telangiectasia
The involvement of ataxia-telangiectasia mutated protein activation in nucleotide excision repair-facilitated cell survival with cisplatin treatment.
Ataxia Telangiectasia
The involvement of c-Myc in the DNA double-strand break repair via regulating radiation-induced phosphorylation of ATM and DNA-PKcs activity.
Ataxia Telangiectasia
The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.
Ataxia Telangiectasia
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication.
Ataxia Telangiectasia
The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.
Ataxia Telangiectasia
The limitations of the G1-S checkpoint.
Ataxia Telangiectasia
The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.
Ataxia Telangiectasia
The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and Induces Apoptosis.
Ataxia Telangiectasia
The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice.
Ataxia Telangiectasia
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
Ataxia Telangiectasia
The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum.
Ataxia Telangiectasia
The Mre11 complex is required for ATM activation and the G2/M checkpoint.
Ataxia Telangiectasia
The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.
Ataxia Telangiectasia
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.
Ataxia Telangiectasia
The mTOR pathway negatively controls ATM by up-regulating miRNAs.
Ataxia Telangiectasia
The multiple facets of the SMC1A gene.
Ataxia Telangiectasia
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Ataxia Telangiectasia
The negative role of cyclin G in ATM-dependent p53 activation.
Ataxia Telangiectasia
The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.
Ataxia Telangiectasia
The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line.
Ataxia Telangiectasia
The nuclear import of oncoprotein hepatitis B X-interacting protein depends on interacting with c-Fos and phosphorylation of both proteins in breast cancer cells.
Ataxia Telangiectasia
The nucleo-shuttling of the ATM protein as a basis for a novel theory of radiation response: resolution of the linear-quadratic model.
Ataxia Telangiectasia
The Nucleoshuttling of the ATM Protein: A Unified Model to Describe the Individual Response to High- and Low-Dose of Radiation?
Ataxia Telangiectasia
The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.
Ataxia Telangiectasia
The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.
Ataxia Telangiectasia
The ovarian DNA damage repair response is induced prior to phosphoramide mustard-induced follicle depletion, and ataxia telangiectasia mutated inhibition prevents PM-induced follicle depletion.
Ataxia Telangiectasia
The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
Ataxia Telangiectasia
The p53 pathway induction is not primarily dependent on Ataxia Telangiectasia Mutated (ATM) gene activity after fludarabine treatment in chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
The p53-53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure.
Ataxia Telangiectasia
The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.
Ataxia Telangiectasia
The PARP inhibitor olaparib induces significant killing of ATM deficient lymphoid tumour cells in vitro and in vivo.
Ataxia Telangiectasia
The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair.
Ataxia Telangiectasia
The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks.
Ataxia Telangiectasia
The prevalence of ataxia telangiectasia mutated (ATM) variants in patients with breast cancer patients: a systematic review and meta-analysis.
Ataxia Telangiectasia
The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11.
Ataxia Telangiectasia
The Protein Arginine Methylase 5 (PRMT5/SKB1) Gene Is Required for the Maintenance of Root Stem Cells in Response to DNA Damage.
Ataxia Telangiectasia
The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer.
Ataxia Telangiectasia
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
Ataxia Telangiectasia
The radiomimetic enediyne C-1027 induces unusual DNA damage responses to double-strand breaks.
Ataxia Telangiectasia
The RAG2 C terminus suppresses genomic instability and lymphomagenesis.
Ataxia Telangiectasia
The regulation of CHK2 in human cancer.
Ataxia Telangiectasia
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway.
Ataxia Telangiectasia
The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function.
Ataxia Telangiectasia
The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.
Ataxia Telangiectasia
The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage.
Ataxia Telangiectasia
The Role and Mechanism of ATM-Mediated Autophagy in the Transition From Hyper-Radiosensitivity to Induced Radioresistance in Lung Cancer Under Low-Dose Radiation.
Ataxia Telangiectasia
The role of ATM and ATR in DNA damage-induced cell cycle control.
Ataxia Telangiectasia
The role of ATM in breast cancer development.
Ataxia Telangiectasia
The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons.
Ataxia Telangiectasia
The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death.
Ataxia Telangiectasia
The role of DNA damage response proteins at telomeres--an "integrative" model.
Ataxia Telangiectasia
The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage.
Ataxia Telangiectasia
The role of oxidized ATM in the regulation of oxidative stress-induced energy metabolism reprogramming of CAFs.
Ataxia Telangiectasia
The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.
Ataxia Telangiectasia
The role of the ataxia telangiectasia mutated gene in lung cancer: recent advances in research.
Ataxia Telangiectasia
The role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotection.
Ataxia Telangiectasia
The Role of the Nuclear Factor ?B Pathway in the Cellular Response to Low and High Linear Energy Transfer Radiation.
Ataxia Telangiectasia
The Roles of 4?-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells.
Ataxia Telangiectasia
The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.
Ataxia Telangiectasia
The telomere deprotection response is functionally distinct from the genomic DNA damage response.
Ataxia Telangiectasia
The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.
Ataxia Telangiectasia
The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.
Ataxia Telangiectasia
The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.
Ataxia Telangiectasia
The versatile functions of ATM kinase.
Ataxia Telangiectasia
The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-?-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex.
Ataxia Telangiectasia
The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase.
Ataxia Telangiectasia
The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress.
Ataxia Telangiectasia
Theasaponin E1 Inhibits Platinum-Resistant Ovarian Cancer Cells through Activating Apoptosis and Suppressing Angiogenesis.
Ataxia Telangiectasia
Therapeutic effect of sodium iodide symporter gene therapy combined with external beam radiotherapy and targeted drugs that inhibit DNA repair.
Ataxia Telangiectasia
Therapeutic Potential of the miRNA-ATM Axis in the Management of Tumor Radioresistance.
Ataxia Telangiectasia
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
Ataxia Telangiectasia
Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer.
Ataxia Telangiectasia
Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints.
Ataxia Telangiectasia
Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex.
Ataxia Telangiectasia
Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification.
Ataxia Telangiectasia
Threonine 2609 phosphorylation of the DNA-dependent Protein Kinase is a critical prerequisite for epidermal growth factor receptor mediated radiation resistance.
Ataxia Telangiectasia
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
Ataxia Telangiectasia
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.
Ataxia Telangiectasia
Thymidylate kinase is critical for DNA repair via ATM-dependent Tip60 complex formation.
Ataxia Telangiectasia
Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer.
Ataxia Telangiectasia
Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia.
Ataxia Telangiectasia
Time, Dose and Ataxia Telangiectasia Mutated (ATM) Status Dependency of Coding and Noncoding RNA Expression after Ionizing Radiation Exposure.
Ataxia Telangiectasia
Tip60 in DNA damage response and growth control: many tricks in one HAT.
Ataxia Telangiectasia
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function.
Ataxia Telangiectasia
TLC388 Induces DNA Damage and G2 Phase Cell Cycle Arrest in Human Non-Small Cell Lung Cancer Cells.
Ataxia Telangiectasia
TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.
Ataxia Telangiectasia
TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.
Ataxia Telangiectasia
Topoisomerase II?-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation.
Ataxia Telangiectasia
Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms.
Ataxia Telangiectasia
Transcription Factors in the Cellular Response to Charged Particle Exposure.
Ataxia Telangiectasia
Transcriptional Regulation at DSBs: Mechanisms and Consequences.
Ataxia Telangiectasia
Transcriptional regulation of ataxia-telangiectasia and Rad3-related protein by activated p21-activated kinase-1 protects keratinocytes in UV-B-induced premalignant skin lesions.
Ataxia Telangiectasia
Transcriptome Analysis of Caco-2 Cells upon the Exposure of Mycotoxin Deoxynivalenol and Its Acetylated Derivatives.
Ataxia Telangiectasia
Transforming growth factor-? regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM.
Ataxia Telangiectasia
Transgenic expression of E2F3a causes DNA damage leading to ATM-dependent apoptosis.
Ataxia Telangiectasia
Transition in Survival From Low-Dose Hyper-Radiosensitivity to Increased Radioresistance Is Independent of Activation of ATM SER1981 Activity.
Ataxia Telangiectasia
Translational initiation regulated by ATM in dendritic cells development.
Ataxia Telangiectasia
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy.
Ataxia Telangiectasia
Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.
Ataxia Telangiectasia
Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes.
Ataxia Telangiectasia
Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-? by macrophages: role of the DNA damage response.
Ataxia Telangiectasia
Tug of War between Survival and Death: Exploring ATM Function in Cancer.
Ataxia Telangiectasia
Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.
Ataxia Telangiectasia
Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-?1 in orchestrating profibrotic responses.
Ataxia Telangiectasia
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways.
Ataxia Telangiectasia
Tumorigenesis and neurodegeneration: two sides of the same coin?
Ataxia Telangiectasia
Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma.
Ataxia Telangiectasia
Twelve novel Atm mutations identified in Chinese ataxia telangiectasia patients.
Ataxia Telangiectasia
Two-phase dynamics of p53 in the DNA damage response.
Ataxia Telangiectasia
Two-stage case-control study of common ATM gene variants in relation to breast cancer risk.
Ataxia Telangiectasia
Type 1 diabetes upregulates metastasis-associated protein 1- phosphorylated histone 2AX signaling in the testis.
Ataxia Telangiectasia
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Ataxia Telangiectasia
Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response.
Ataxia Telangiectasia
UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.
Ataxia Telangiectasia
UFL1 promotes histone H4 ufmylation and ATM activation.
Ataxia Telangiectasia
Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells.
Ataxia Telangiectasia
Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination.
Ataxia Telangiectasia
Unusual case of leukemic mantle cell lymphoma with amplified CCND1/IGH fusion gene.
Ataxia Telangiectasia
Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease.
Ataxia Telangiectasia
USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status.
Ataxia Telangiectasia
Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.
Ataxia Telangiectasia
Utilizing protein phosphatase inhibitors to define PP2A as a regulator of ataxia-telangiectasia mutated.
Ataxia Telangiectasia
UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity.
Ataxia Telangiectasia
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.
Ataxia Telangiectasia
Validation of the cell cycle G(2) delay assay in assessing ionizing radiation sensitivity and breast cancer risk.
Ataxia Telangiectasia
Vanillin protects human keratinocyte stem cells against ultraviolet B irradiation.
Ataxia Telangiectasia
Variation in Telangiectasia Predisposing Genes Is Associated With Overall Radiation Toxicity.
Ataxia Telangiectasia
Variation of ATM Gene Expression in Peripheral Blood Cells of Sporadic Breast Carcinomas in Iranian Patients.
Ataxia Telangiectasia
Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.
Ataxia Telangiectasia
Vasculogenic Mimicry Formation Predicts Tumor Progression in Oligodendroglioma.
Ataxia Telangiectasia
Venetoclax and dexamethasone synergize with inotuzumab ozogamicin-induced DNA damage signaling in B-lineage ALL.
Ataxia Telangiectasia
Viral DNA replication-dependent DNA damage response activation during BK polyomavirus infection.
Ataxia Telangiectasia
Walking forward: a program designed to lower cancer mortality rates among American Indians in western South Dakota.
Ataxia Telangiectasia
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Ataxia Telangiectasia
Werner Syndrome Protein and DNA Replication.
Ataxia Telangiectasia
When heat casts a spell on the DNA damage checkpoints.
Ataxia Telangiectasia
When the guardian becomes the enemy: Targeting ATM in PTEN-deficient cancers.
Ataxia Telangiectasia
Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia.
Ataxia Telangiectasia
Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis.
Ataxia Telangiectasia
Wip1 phosphatase modulates ATM-dependent signaling pathways.
Ataxia Telangiectasia
WIP1, a homeostatic regulator of the DNA damage response, is targeted by HIPK2 for phosphorylation and degradation.
Ataxia Telangiectasia
Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002.
Ataxia Telangiectasia
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, induces accumulation of DNA double-strand breaks.
Ataxia Telangiectasia
Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis.
Ataxia Telangiectasia
Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent.
Ataxia Telangiectasia
XCIND as a genetic disease of X-irradiation hypersensitivity and cancer susceptibility.
Ataxia Telangiectasia
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint.
Ataxia Telangiectasia
XRCC2 Regulates Replication Fork Progression during dNTP Alterations.
Ataxia Telangiectasia
YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases.
Ataxia Telangiectasia
ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM.
Ataxia Telangiectasia
Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation.
Ataxia Telangiectasia
ZnO nanoparticles-associated mitochondrial stress-induced apoptosis and G2/M arrest in HaCaT cells: a mechanistic approach.
Ataxia Telangiectasia
[Adjuvant irradiation in breast cancer patients with ATM gene heterozygous mutations: Special focus on clinical efficacy/toxicity.]
Ataxia Telangiectasia
[Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease].
Ataxia Telangiectasia
[Association between single nucleotide polymorphism locus rs189037 in the promoter of ATM gene and nasopharyngeal carcinoma susceptibility in Cantonese].
Ataxia Telangiectasia
[Ataxia-telangiectasia mutated gene and breast cancer susceptibility]
Ataxia Telangiectasia
[Complete heart block and asystole in a child with ataxia-telangiectasia].
Ataxia Telangiectasia
[Employing DNA Damage Response Inhibitors to Enhance Chemosensitivity of Ovarian Carcinoma Cells].
Ataxia Telangiectasia
[Gene atm and Chronic Lymphocytic Leukemia - Review.]
Ataxia Telangiectasia
[Jaridonin, a new diterpenoid from Isodon rubescens, induces cell cycle arrest in gastric cancer cells through activating ataxia telangiectasia mutated kinase].
Ataxia Telangiectasia
[Knockdown of DNA-PKcs inhibits cell cycle and its mechanism of drug-resistant Bel7402/5-Fu hepatocellular carcinoma cells].
Ataxia Telangiectasia
[miR-18a enhances the radiosensitivity of nasopharyngeal carcinoma cells through inducing autophagy].
Ataxia Telangiectasia
[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]
Ataxia Telangiectasia
[Relationship of HepG2 cell sensitivity to continuous low dose-rate irradiation with ataxia-telangiectasia mutated phosphorylation]
Ataxia Telangiectasia
[Research advance of retinal pathological angiogenesis related to ATM protein kinase].
Ataxia Telangiectasia
[Single nucleotide polymorphisms and point mutations of ataxia telangiectasia mutated gene in Chinese of Han ethnicity.]
Ataxia Telangiectasia
[Study on the Effect of Overexpression of miR-18a on Cellular Proliferation and Migration by Targeting ATM in Human Colorectal Cancer Cells].
Ataxia Telangiectasia
[Suppression of ATR reverses the cisplatin resistance in ovarian cancer SKOV3 cells].
Ataxia Telangiectasia
[The Role of DNA Double-strain Damage Repairing Mechanisms in Diabetic Atheroscolersis].
Ataxia Telangiectasia
[Topoisomerase inhibitor upregulates MICA/B expression in breast cancer cells through ATM/ATR and NF-?B pathway].
Ataxia Telangiectasia
[Up-regulation of major histocompatibility complex class I-related molecules A (MICA) induced by 5-aza-2'-deoxycytidine.]
Atherosclerosis
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Atherosclerosis
Absence of Gravin Mediated Signaling Inhibits Development of High Fat Diet-Induced Hyperlipidemia and Atherosclerosis.
Atherosclerosis
Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice.
Atherosclerosis
Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease.
Atherosclerosis
ALK5 deficiency inhibits macrophage inflammation and lipid loading by targeting KLF4.
Atherosclerosis
Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque.
Atherosclerosis
CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REG?.
Atherosclerosis
Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-gamma-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis.
Atherosclerosis
Curcumin: from food spice to cancer prevention.
Atherosclerosis
Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase 2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway.
Atherosclerosis
Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.
Atherosclerosis
Differential responsiveness of early- and late-passage endothelial cells to shear stress.
Atherosclerosis
Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis.
Atherosclerosis
Identification and characterization of the druggable kinase targets of olmesartan and its analogues from a systematic kinase-chemical interaction profile in atherosclerosis.
Atherosclerosis
Individual Radiosensitivity Assessment of the Families of Ataxia-Telangiectasia Patients by G2-Checkpoint Abrogation.
Atherosclerosis
Inhibition of c-Jun N-terminal Kinase Attenuates Low Shear Stress-Induced Atherogenesis in Apolipoprotein E-deficient Mice.
Atherosclerosis
Inhibition of p90RSK is critical to abolish Angiotensin II-induced rat aortic smooth muscle cell proliferation and migration.
Atherosclerosis
Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation.
Atherosclerosis
Knockdown of lnc-KCNC3-3:1 Alleviates the Development of Atherosclerosis via Downregulation of JAK1/STAT3 Signaling Pathway.
Atherosclerosis
Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.
Atherosclerosis
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.
Atherosclerosis
MicroRNA-145 alleviates high glucose-induced proliferation and migration of vascular smooth muscle cells through targeting ROCK1.
Atherosclerosis
Over-expression of angiotensin II type 2 receptor (agtr2) reduces atherogenesis and modulates LOX-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression.
Atherosclerosis
Pim-2 kinase inhibits inflammation by suppressing the mTORC1 pathway in atherosclerosis.
Atherosclerosis
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Atherosclerosis
Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
Atherosclerosis
Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
Atherosclerosis
SNHG6 modulates oxidized low-density lipoprotein-induced endothelial cells injury through miR-135a-5p/ROCK in atherosclerosis.
Atherosclerosis
Structure-based design of small molecule and peptide inhibitors for selective targeting of ROCK1: an integrative computational approach.
Atherosclerosis
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Atherosclerosis
Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice.
Atherosclerosis
The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study.
Atherosclerosis
The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice.
Atherosclerosis
Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis.
Atherosclerosis
[Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease].
Atherosclerosis
[Effect of Buyang Huanwu Decoction on mRNA Expressions of Aorta Rho Kinase and NF-?B p65 in Atherosclerosis Model Rats].
Atrial Fibrillation
Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal.
Atrial Fibrillation
c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.
Atrial Fibrillation
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation.
Atrial Fibrillation
Calcium dysregulation in atrial fibrillation: the role of CaMKII.
Atrial Fibrillation
Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation.
Atrial Fibrillation
CaMKII oxidative activation and the pathogenesis of cardiac disease.
Atrial Fibrillation
CaMKII regulation of voltage-gated Na channels and cell excitability.
Atrial Fibrillation
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Atrial Fibrillation
Circ-Zfp644 acts as a pro-hypertrophic mediator in an Ang-II induced in vitro myocardial hypertrophy model.
Atrial Fibrillation
Enhanced CaMKII-Dependent Late INa Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.
Atrial Fibrillation
Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.
Atrial Fibrillation
Inhibitions of late INa and CaMKII act synergistically to prevent ATX-II-induced atrial fibrillation in isolated rat right atria.
Atrial Fibrillation
Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.
Atrial Fibrillation
Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use?
Atrial Fibrillation
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms.
Atrial Fibrillation
Oxidized CaMKII Triggers Atrial Fibrillation.
Atrial Fibrillation
Regulation of the transient outward K(+) current by Ca(2+)/calmodulin-dependent protein kinases II in human atrial myocytes.
Atrial Fibrillation
The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity.
Atrial Fibrillation
The Role of CaMKII Overexpression and Oxidation in Atrial Fibrillation-A Simulation Study.
Atrial Fibrillation
The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart.
Atrial Fibrillation
Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats.
Atrial Premature Complexes
Enhanced CaMKII-Dependent Late INa Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.
Atrial Premature Complexes
The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity.
Atrioventricular Block
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Autoimmune Diseases
Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha.
Autoimmune Diseases
BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2+-CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells.
Autoimmune Diseases
BAFF inhibits autophagy promoting cell proliferation and survival by activating Ca2+-CaMKII-dependent Akt/mTOR signaling pathway in normal and neoplastic B-lymphoid cells.
Autoimmune Diseases
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.
Autoimmune Diseases
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.
Autoimmune Diseases
GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration.
Autoimmune Diseases
hsBAFF promotes proliferation and survival in cultured B lymphocytes via calcium signaling activation of mTOR pathway.
Autoimmune Diseases
Involvement of DNA-PKcs in the IL-6 and IL-12 Response to CpG-ODN Is Mediated by Its Interaction with TRAF6 in Dendritic Cells.
Autoimmune Diseases
Long non-coding RNA growth arrest-specific transcript 5 regulates rheumatoid arthritis by targeting homeodomain-interacting protein kinase 2.
Autoimmune Diseases
NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo.
Autoimmune Diseases
RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases.
Autoimmune Diseases
Synthesis and structure-activity relationship studies of 2-(1,3,4-oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as inhibitors of DRAK2.
Avian Leukosis
Induction of host gene expression following infection of chicken embryo fibroblasts with oncogenic Marek's disease virus.
Avitaminosis
B Vitamin Deficiency Promotes Tau Phosphorylation Through Regulation of GSK3beta and PP2A.
Avitaminosis
B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A.
Azoospermia
A PLK4 mutation causing azoospermia in a man with Sertoli cell-only syndrome.
Azoospermia
A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans.
Azoospermia
Gene and histomorphology alteration analysis in spermatogenesis arrest mouse model: a probable novel approach for infertility.
Azoospermia
Mutation screening and association study of the TSSK4 Gene in Chinese infertile men with impaired spermatogenesis.
Azoospermia
Some Single Nucleotide Polymorphisms of the TSSK2 Gene May Be Associated with Human Spermatogenesis Impairment.
Azoospermia
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Bacterial Infections
A Proteasome-regulated glycogen synthase kinase-3 modulates disease response in plants.
Bacterial Infections
Anthrapyrazolone analogues intercept inflammatory JNK signals to moderate endotoxin induced septic shock.
Bacterial Infections
c-Jun N-terminal kinase (JNK) is involved in immune defense against bacterial infection in Crassostrea hongkongensis.
Bacterial Infections
Critical Role of Glycogen Synthase Kinase-3? in Regulating the Avian Heterophil Response to Salmonella enterica Serovar Enteritidis.
Bacterial Infections
Genome-wide identification of PTI1 family in Setaria italica and salinity-responsive functional analysis of SiPTI1-5.
Bacterial Infections
Glycogen Synthase Kinase 3? Is the Main Isoform That Regulates the Transcription Factors Nuclear Factor-Kappa B and cAMP Response Element Binding in Bovine Endothelial Cells Infected with
Bacterial Infections
Identification of the 14-3-3 ?/?-A protein as a novel maternal peptidoglycan-binding protein that protects embryos of zebrafish against bacterial infections.
Bacterial Infections
Leucine Rich Repeat Kinase 2 and Innate Immunity.
Bacterial Infections
LRRK2 at the Interface Between Peripheral and Central Immune Function in Parkinson's.
Bacterial Infections
mTOR signaling mediates ILC3-driven immunopathology.
Bacterial Infections
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Bacterial Infections
Recognition of Lipopolysaccharide and Activation of NF-?B by Cytosolic Sensor NOD1 in Teleost Fish.
Bacterial Infections
Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation.
Barrett Esophagus
Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia.
Barth Syndrome
Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome.
Basal Cell Nevus Syndrome
Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors?
Behcet Syndrome
Association of LACC1, CEBPB-PTPN1, RIPK2 and ADO-EGR2 with ocular Behcet's disease in a Chinese Han population.
Bile Duct Neoplasms
Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.
Biliary Tract Neoplasms
Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients.
Blast Crisis
ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia.
Blast Crisis
BCR-ABL down-regulates the DNA repair protein DNA-PKcs.
Blast Crisis
LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.
Blast Crisis
Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein.
Blindness, Cortical
Sporadic Creutzfeldt-Jakob disease in a native Puerto Rican patient.
Blister
Coordinated changes in cell membrane and cytoplasm during maturation of apoptotic bleb.
Blister
The Diaphanous-related Formin FHOD1 Associates with ROCK1 and Promotes Src-dependent Plasma Membrane Blebbing.
Bloom Syndrome
Identification of proteins in the hamster DNA end-binding complex.
Bloom Syndrome
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Bluetongue
Cellular Casein Kinase 2 and Protein Phosphatase 2A Modulate Replication Site Assembly of Bluetongue Virus.
Bone Diseases
Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.
Bone Diseases
Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats.
Bone Diseases
Osteocytes Specific GSK3 Inhibition Affects In Vitro Osteogenic Differentiation.
Bone Diseases
Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.
Bone Diseases, Metabolic
Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation.
Bone Diseases, Metabolic
Inhibition of glycogen synthase kinase-3beta attenuates glucocorticoid-induced bone loss.
Bone Diseases, Metabolic
Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses.
Bone Marrow Failure Disorders
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.
Bone Marrow Failure Disorders
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.
Bone Neoplasms
Activation of spinal TDAG8 and its downstream PKA signaling pathway contribute to bone cancer pain in rats.
Bone Neoplasms
Blocking mammalian target of rapamycin alleviates bone cancer pain and morphine tolerance via µ-opioid receptor.
Bone Neoplasms
Cellular and molecular mechanisms of calcium/calmodulin-dependent protein kinase II in chronic pain.
Bone Neoplasms
Electroacupuncture Attenuates Morphine Tolerance in Rats with Bone Cancer Pain by Inhibiting PI3K/Akt/JNK1/2 Signaling Pathway in the Spinal Dorsal Horn.
Bone Neoplasms
The inhibitor of calcium/calmodulin-dependent protein kinase II KN93 attenuates bone cancer pain via inhibition of KIF17/NR2B trafficking in mice.
Bone Resorption
CaMKII(?) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway.
Bone Resorption
Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption.
Bone Resorption
Deficiency of PDK1 in osteoclasts delays fracture healing and repair.
Bone Resorption
Functions of Rho family of small GTPases and Rho-associated coiled-coil kinases in bone cells during differentiation and mineralization.
Bone Resorption
Hyperglycemia Induces Osteoclastogenesis and Bone Destruction Through the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II.
Bone Resorption
Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice.
Bone Resorption
Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model.
Bone Resorption
Prostaglandin E2 directly inhibits bone-resorbing activity of isolated mature osteoclasts mainly through the EP4 receptor.
Bone Resorption
PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells.
Bone Resorption
Small molecule GSK-3 antagonists play a pivotal role in reducing the local inflammatory response, in promoting resident stem cell activation and in improving tissue repairing in regenerative dentistry.
Bone Resorption
Surface modification of titanium manufactured through selective laser melting inhibited osteoclast differentiation through mitogen-activated protein kinase signaling pathway.
Bone Resorption
Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation.
Borna Disease
Borna disease virus P-protein is phosphorylated by protein kinase Cepsilon and casein kinase II.
Bowen's Disease
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
Brachydactyly
A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2.
Bradycardia
Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway.
Bradycardia
Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway.
Bradycardia
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.
Bradycardia
The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: Implications for neural control of cardiac excitability.
Brain Concussion
Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury.
Brain Contusion
c-Jun N-terminal kinase pathway activation in human and experimental cerebral contusion.
Brain Contusion
Temporal and regional changes in IGF-1/IGF-1R signaling in the mouse brain following traumatic brain injury.
Brain Contusion
Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats.
Brain Death
Myocardial protective effects of a c-Jun N-terminal kinase inhibitor in rats with brain death.
Brain Diseases
14-3-3 protein detection in the cerebrospinal fluid of patients with influenza-associated encephalopathy.
Brain Diseases
14-3-3 protein in the CSF of a patient with Hashimoto's encephalopathy.
Brain Diseases
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Brain Diseases
Bi-directional genetic modulation of GSK-3? exacerbates hippocampal neuropathology in experimental status epilepticus.
Brain Diseases
Cerebrospinal fluid non-phosphorylated tau in the differential diagnosis of Creutzfeldt-Jakob disease: a comparative prospective study with 14-3-3.
Brain Diseases
Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase.
Brain Diseases
Detection of 14-3-3 protein in the cerebrospinal fluid in mitochondrial encephalopathy with lactic acidosis and stroke-like episodes.
Brain Diseases
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease.
Brain Diseases
Detection of 14-3-3 protein in the CSF of a patient with Hashimoto's encephalopathy.
Brain Diseases
Different expression patterns of CK2 subunits in the brains of experimental animals and patients with transmissible spongiform encephalopathies.
Brain Diseases
Emerging roles of 14-3-3? in the brain disorder.
Brain Diseases
Glycogen synthase kinase-3 as a therapeutic target for cognitive dysfunction in neuropsychiatric disorders.
Brain Diseases
GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke.
Brain Diseases
Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons.
Brain Diseases
Lethal neonatal rigidity and multifocal seizure syndrome with a new mutation in BRAT1.
Brain Diseases
Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder?
Brain Diseases
Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies.
Brain Diseases
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
Brain Diseases
Prolongation of life in rats with malignant glioma by intranasal siRNA/drug co-delivery to the brain with cell-penetrating peptide-modified micelles.
Brain Diseases
Radiosynthesis and in Vivo Evaluation of [(11)C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain.
Brain Diseases
Rationale for diagnosing human prion disease.
Brain Diseases
Sporadic Creutzfeldt-Jakob Disease With Unilateral Symptoms in the Setting of Metastatic Renal Cell Carcinoma.
Brain Diseases
The 14-3-3 brain protein and transmissible spongiform encephalopathy.
Brain Diseases
The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.
Brain Diseases
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
Brain Diseases
The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease.
Brain Diseases
The Nav1.2 channel is regulated by GSK3.
Brain Diseases
Time-course studies of 14-3-3 protein isoforms in cerebrospinal fluid and brain of primates after oral or intracerebral infection with bovine spongiform encephalopathy agent.
Brain Diseases
What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.
Brain Diseases
Yeast 14-3-3 proteins.
Brain Diseases
[A case of steroid-responsive encephalopathy with positive 14-3-3 protein of the cerebrospinal fluid clinically resembling Creutzfelt-Jakob disease]
Brain Diseases
[Diagnosis of transmissible spongiform encephalopathies in Spain. Population perspective]
Brain Edema
Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice.
Brain Edema
Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage.
Brain Edema
Effects of isoflurane on brain inflammation after subarachnoid hemorrhage in mice.
Brain Edema
Ghrelin alleviates early brain injury after subarachnoid hemorrhage via the PI3K/Akt signaling pathway.
Brain Edema
Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
Brain Edema
Isoflurane preconditioning protects rat brain from ischemia reperfusion injury via up-regulating the HIF-1? expression through Akt/mTOR/s6K activation.
Brain Edema
Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway.
Brain Edema
[Effect of thyroxine on the expression of HIF-1? after aneurysmal subarachnoid hemorrhage in rat brain and its mechanism].
Brain Infarction
Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection.
Brain Infarction
Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling.
Brain Infarction
Neuronal death in brain infarcts in man.
Brain Infarction
Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion.
Brain Infarction
Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition.
Brain Injuries
A Combined Proteomics and Bioinformatics Approach Reveals Novel Signaling Pathways and Molecular Targets After Intracerebral Hemorrhage.
Brain Injuries
Activation of the Protein Kinase B (Akt) Reduces Nur77-induced Apoptosis During Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rat.
Brain Injuries
Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell death.
Brain Injuries
Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats.
Brain Injuries
Astrocytic Expression of CTMP Following an Excitotoxic Lesion in the Mouse Hippocampus.
Brain Injuries
Bi-directional genetic modulation of GSK-3? exacerbates hippocampal neuropathology in experimental status epilepticus.
Brain Injuries
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.
Brain Injuries
Brain injury induces HIF-1?-dependent transcriptional activation of LRRK2 that exacerbates brain damage.
Brain Injuries
Brain ischemia/reperfusion-induced expression of DP5 and its interaction with Bcl-2, thus freeing Bax from Bcl-2/Bax dimmers are mediated by c-Jun N-terminal kinase (JNK) pathway.
Brain Injuries
Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats.
Brain Injuries
CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1.
Brain Injuries
Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders.
Brain Injuries
Delayed administration of a potent cyclin dependent kinase and glycogen synthase kinase 3 beta inhibitor produces long-term neuroprotection in a hypoxia-ischemia model of brain injury.
Brain Injuries
Differential activation of ERK, p38, and JNK MAPK by nociceptin/orphanin FQ in the potentiation of prostaglandin cerebrovasoconstriction after brain injury.
Brain Injuries
Differential early mitogen-activated protein kinase activation in hyperglycemic ischemic brain injury in the rat.
Brain Injuries
Dual inhibitory roles of geldanamycin on the c-Jun NH(2)-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury.
Brain Injuries
Effects of isoflurane on brain inflammation after subarachnoid hemorrhage in mice.
Brain Injuries
Estradiol prevents the injury-induced decrease of Akt/glycogen synthase kinase 3beta phosphorylation.
Brain Injuries
Etanercept Alleviates Early Brain Injury Following Experimental Subarachnoid Hemorrhage and the Possible Role of Tumor Necrosis Factor-? and c-Jun N-Terminal Kinase Pathway.
Brain Injuries
Glucagon Protects Against Impaired NMDA-Mediated Cerebrovasodilation and Cerebral Autoregulation during Hypotension after Brain Injury by Activating cAMP Protein Kinase A and Inhibiting Upregulation of tPA.
Brain Injuries
Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.
Brain Injuries
GSK-3?/mTORC1 Couples Synaptogenesis and Axonal Repair to Reduce Hypoxia Ischemia-Mediated Brain Injury in Neonatal Rats.
Brain Injuries
Immunoreactive Akt, PI3-K and ERK protein kinase expression in ischemic rat brain.
Brain Injuries
Increased expression of receptor for advanced glycation end-products worsens focal brain ischemia in diabetic rats.
Brain Injuries
Inhibition of c-Jun N-terminal kinase ameliorates early brain injury after subarachnoid hemorrhage through inhibition of a Nur77 dependent apoptosis pathway.
Brain Injuries
Inhibition of HDAC4 Attenuated JNK/c-Jun-Dependent Neuronal Apoptosis and Early Brain Injury Following Subarachnoid Hemorrhage by Transcriptionally Suppressing MKK7.
Brain Injuries
Insulin Receptor Substrate-1 Activation Mediated p53 Downregulation Protects Against Hypoxic-Ischemia in the Neonatal Brain.
Brain Injuries
JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke.
Brain Injuries
K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.
Brain Injuries
Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway.
Brain Injuries
LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats.
Brain Injuries
LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.
Brain Injuries
Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3.
Brain Injuries
Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway.
Brain Injuries
Neuroprotection against ischemic brain injury by a small peptide inhibitor of c-Jun N-terminal kinase (JNK) via nuclear and non-nuclear pathways.
Brain Injuries
nNOS downregulation attenuates neuronal apoptosis by inhibiting nNOS-GluR6 interaction and GluR6 nitrosylation in cerebral ischemic reperfusion.
Brain Injuries
Perinatal nicotine exposure alters Akt/GSK-3?/mTOR/autophagy signaling, leading to development of hypoxic-ischemic-sensitive phenotype in rat neonatal brain.
Brain Injuries
Possible Role of Raf-1 Kinase in the Development of Cerebral Vasospasm and Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats.
Brain Injuries
Progesterone alleviates hypoxic-ischemic brain injury via the Akt/GSK-3? signaling pathway.
Brain Injuries
Protection against malonate-induced ischemic brain injury in rat by a cell-permeable peptidic c-Jun N-terminal kinase inhibitor, (L)-HIV-TAT48-57-PP-JBD20, observed by the apparent diffusion coefficient mapping magnetic resonance imaging method.
Brain Injuries
RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats.
Brain Injuries
Reduction of ischemic brain injury by topical application of insulin-like growth factor-I after transient middle cerebral artery occlusion in rats.
Brain Injuries
Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.
Brain Injuries
Remifentanil preconditioning alleviating brain damage of cerebral ischemia reperfusion rats by regulating the JNK signal pathway and TNF-?/TNFR1 signal pathway.
Brain Injuries
Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage.
Brain Injuries
Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury.
Brain Injuries
Targeting the Dvl-1/?-arrestin2/JNK3 interaction disrupts Wnt5a-JNK3 signaling and protects hippocampal CA1 neurons during cerebral ischemia reperfusion.
Brain Injuries
The protective effect of bone marrow mesenchymal stem cells in a rat model of ischemic stroke via reducing the C-Jun N-terminal kinase expression.
Brain Injuries
The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus.
Brain Injuries
Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation.
Brain Injuries
[Effect of Schisandra chinensis lignans on neuronal apoptosis and p-AKT expression of rats in cerebral ischemia injury model].
Brain Injuries
[Significance and expression of FKHR and AKT after subarachnoid hemorrhage in rat brain cortex].
Brain Injuries, Diffuse
[Effect of expression of c-jun N-terminal kinase on neuron autophagy following diffuse brain injury in rats].
Brain Injuries, Traumatic
?-Synuclein is a pathological link and therapeutic target for Parkinson's disease and traumatic brain injury.
Brain Injuries, Traumatic
Are GLP-1 receptor agonists useful against traumatic brain injury?
Brain Injuries, Traumatic
Brain injury induces HIF-1?-dependent transcriptional activation of LRRK2 that exacerbates brain damage.
Brain Injuries, Traumatic
Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability.
Brain Injuries, Traumatic
Different functions of HIPK2 and CtBP2 in traumatic brain injury.
Brain Injuries, Traumatic
Expression of serine/threonine kinase receptors in traumatic brain injury.
Brain Injuries, Traumatic
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Brain Injuries, Traumatic
Glycogen synthase kinase-3: The missing link to aberrant circuit function in disorders of cognitive dysfunction?
Brain Injuries, Traumatic
Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats.
Brain Injuries, Traumatic
Inhibition of c-Jun N-Terminal Kinase Protects Against Brain Damage and Improves Learning and Memory After Traumatic Brain Injury in Adult Mice.
Brain Injuries, Traumatic
Inhibition of death-associated protein kinase 1 attenuates cis P-tau and neurodegeneration in traumatic brain injury.
Brain Injuries, Traumatic
Inhibition of glycogen synthase kinase-3: an emerging target in the treatment of traumatic brain injury.
Brain Injuries, Traumatic
Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat.
Brain Injuries, Traumatic
LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats.
Brain Injuries, Traumatic
Magnesium Lithospermate B Implicates 3'-5'-Cyclic Adenosine Monophosphate/Protein Kinase A Pathway and N-Methyl-d-Aspartate Receptors in an Experimental Traumatic Brain Injury.
Brain Injuries, Traumatic
Mechanical injury modulates AMPA receptor kinetics via an NMDA receptor-dependent pathway.
Brain Injuries, Traumatic
Proteins released from degenerating neurons are surrogate markers for acute brain damage.
Brain Injuries, Traumatic
Small interfering RNA directed against CTMP reduces acute traumatic brain injury in a mouse model by activating Akt.
Brain Injuries, Traumatic
The selectivity and promiscuity of brain-neuroregenerative inhibitors between ROCK1 and ROCK2 isoforms: An integration of SB-QSSR modelling, QM/MM analysis and in vitro kinase assay.
Brain Ischemia
A critical role of neural-specific JNK3 for ischemic apoptosis.
Brain Ischemia
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia.
Brain Ischemia
Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia.
Brain Ischemia
Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma.
Brain Ischemia
Activation of c-Jun N-terminal kinase 1/2 regulated by nitric oxide is associated with neuronal survival in hippocampal neurons in a rat model of ischemia.
Brain Ischemia
Activation of c-Jun N-terminal kinase and p38 after cerebral ischemia upregulates cerebral sodium-glucose transporter type 1.
Brain Ischemia
Akt/Bad signaling and motor neuron survival after spinal cord injury.
Brain Ischemia
Altered Prion protein expression pattern in CSF as a biomarker for Creutzfeldt-Jakob disease.
Brain Ischemia
Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats.
Brain Ischemia
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Brain Ischemia
c-Jun N-terminal kinase activation in hippocampal CA1 region was involved in ischemic injury.
Brain Ischemia
Ca2+/calmodulin-dependent protein kinase II in postsynaptic densities after reversible cerebral ischemia in rats.
Brain Ischemia
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
Brain Ischemia
CaMKII in cerebral ischemia.
Brain Ischemia
Cerebral ischemia induces transient intracellular redistribution and intranuclear translocation of the raf proto-oncogene product in hippocampal pyramidal cells.
Brain Ischemia
Changes of Ca2+/calmodulin-dependent protein kinase-II after transient ischemia in gerbil hippocampus.
Brain Ischemia
CK2 inhibition protects white matter from ischemic injury.
Brain Ischemia
Co-induction of alphaB-crystallin and MAPKAPK-2 in astrocytes in the penumbra after transient focal cerebral ischemia.
Brain Ischemia
Coagulation factor Xa activates thrombin in ischemic neural tissue.
Brain Ischemia
D-JNKi, a peptide inhibitor of c-Jun N-terminal kinase, promotes functional recovery after transient focal cerebral ischemia in rats.
Brain Ischemia
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Brain Ischemia
Dehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation.
Brain Ischemia
Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia.
Brain Ischemia
Dexmedetomidine attenuates cerebral ischemia-reperfusion injury in rats by inhibiting the JNK pathway.
Brain Ischemia
Different expression of glycogen synthase kinase-3beta between young and old rat brains after transient middle cerebral artery occlusion.
Brain Ischemia
Differential expression of PTEN in normal adult rat brain and upregulation of PTEN and p-Akt in the ischemic cerebral cortex.
Brain Ischemia
Distinct Roles of ROCK1 and ROCK2 on the Cerebral Ischemia Injury and Subsequently Neurodegenerative Changes.
Brain Ischemia
Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.
Brain Ischemia
Dynamic Changes in miR-126 Expression in the Hippocampus and Penumbra Following Experimental Transient Global and Focal Cerebral Ischemia-Reperfusion.
Brain Ischemia
Effects of FK506 on the translocation of protein kinase C and CaM kinase II in the gerbil hippocampal CA1 neurons.
Brain Ischemia
Electroconvulsive seizure-induced VEGF is correlated with neuroprotective effects against cerebral infarction: Involvement of the phosphatidylinositol-3 kinase/Akt pathway.
Brain Ischemia
Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor.
Brain Ischemia
Exogenous nitric oxide negatively regulates c-Jun N-terminal kinase activation via inhibiting endogenous NO-induced S-nitrosylation during cerebral ischemia and reperfusion in rat hippocampus.
Brain Ischemia
GHB analogs confer neuroprotection through specific interaction with the CaMKII? hub domain.
Brain Ischemia
Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia.
Brain Ischemia
Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential.
Brain Ischemia
Heme oxygenase-1 regulates the JNK signaling pathway through the MLK3-MKK7-JNK3 signaling module in brain ischemia injury.
Brain Ischemia
Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex.
Brain Ischemia
Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation.
Brain Ischemia
Increased expression of receptor for advanced glycation end-products worsens focal brain ischemia in diabetic rats.
Brain Ischemia
Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions.
Brain Ischemia
Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus.
Brain Ischemia
Lack of neuroprotection of inhibitory peptides targeting Jun/JNK after transient focal cerebral ischemia in spontaneously hypertensive rats.
Brain Ischemia
Limited role of the c-Jun N-terminal kinase pathway in a neonatal rat model of cerebral hypoxia-ischemia.
Brain Ischemia
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Brain Ischemia
Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxia-Ischemia.
Brain Ischemia
Mild hypothermia decreases GSK3beta expression following global cerebral ischemia.
Brain Ischemia
N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel activation mediate proline-rich tyrosine kinase 2 phosphorylation during cerebral ischemia in rats.
Brain Ischemia
N-methyl-D-aspartate receptors mediate diphosphorylation of extracellular signal-regulated kinases through Src family tyrosine kinases and Ca2+/calmodulin-dependent protein kinase II in rat hippocampus after cerebral ischemia.
Brain Ischemia
Necrotic death of neurons following an excitotoxic insult is prevented by a peptide inhibitor of c-jun N-terminal kinase.
Brain Ischemia
Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats.
Brain Ischemia
Neuroprotection by inhibiting the c-Jun N-terminal kinase pathway after cerebral ischemia occurs independently of interleukin-6 and keratinocyte-derived chemokine (KC/CXCL1) secretion.
Brain Ischemia
Neuroprotective Effect of TAT-14-3-3? Fusion Protein against Cerebral Ischemia/Reperfusion Injury in Rats.
Brain Ischemia
Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia.
Brain Ischemia
Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
Brain Ischemia
Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat.
Brain Ischemia
Opposite reaction of ERK and JNK in ischemia vulnerable and resistant regions of hippocampus: involvement of mitochondria.
Brain Ischemia
p38/SAPK2 controls gap junction closure in astrocytes.
Brain Ischemia
Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.
Brain Ischemia
Persistent translocation of Ca2+/calmodulin-dependent protein kinase II to synaptic junctions in the vulnerable hippocampal CA1 region following transient ischemia.
Brain Ischemia
Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain.
Brain Ischemia
Post-ischemic salubrinal administration reduces necroptosis in a rat model of global cerebral ischemia.
Brain Ischemia
Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies.
Brain Ischemia
Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats.
Brain Ischemia
PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus.
Brain Ischemia
Quercetin Attenuates Cell Apoptosis in Focal Cerebral Ischemia Rat Brain Via Activation of BDNF-TrkB-PI3K/Akt Signaling Pathway.
Brain Ischemia
Reduction of ischemic brain injury by topical application of insulin-like growth factor-I after transient middle cerebral artery occlusion in rats.
Brain Ischemia
Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage.
Brain Ischemia
Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons.
Brain Ischemia
Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury.
Brain Ischemia
Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling.
Brain Ischemia
The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia.
Brain Ischemia
The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways.
Brain Ischemia
The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats.
Brain Ischemia
The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion.
Brain Ischemia
Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation.
Brain Ischemia
[Effect of electroacupuncture on CD 34+ endothelial progenitor cell counts in bone marrow and peripheral blood in focal cerebral ischemia/reperfusion rats].
Brain Ischemia
[Effect of Schisandra chinensis lignans on neuronal apoptosis and p-AKT expression of rats in cerebral ischemia injury model].
Brain Ischemia
[Influence of acupuncture intervention on neurologic deficits, cerebrocortical cell apoptosis and Protein kinase A expression in rats with focal cerebral ischemia].
Brain Neoplasms
A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors.
Brain Neoplasms
AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors.
Brain Neoplasms
Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression.
Brain Neoplasms
Development of dual casein kinase 1?/1? (CK1?/?) inhibitors for treatment of breast cancer.
Brain Neoplasms
Diffusible Factors Secreted by Glioblastoma and Medulloblastoma Cells Induce Oxidative Stress in Bystander Neural Stem Progenitors.
Brain Neoplasms
Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications.
Brain Neoplasms
Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis.
Brain Neoplasms
Emerging roles of glycogen synthase kinase 3 in the treatment of brain tumors.
Brain Neoplasms
Evolutionary model of brain tumor circulating cells: Cellular galaxy.
Brain Neoplasms
Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors.
Brain Neoplasms
Identification of an EGFRvIII-JNK2-HGF/c-Met-Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion.
Brain Neoplasms
Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy.
Brain Neoplasms
Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma.
Brain Neoplasms
Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma.
Brain Neoplasms
Preclinical Pharmacological Evaluation of a Novel Multiple Kinase Inhibitor, ON123300, in Brain Tumor Models.
Brain Neoplasms
Promoter methylation status of multiple genes in brain metastases of solid tumors.
Brain Neoplasms
Protein kinase A regulatory subunit distribution in medulloblastoma.
Brain Neoplasms
Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells.
Brain Neoplasms
Rapid induction of the Grp78 gene by cooperative actions of okadaic acid and heat-shock in 9L rat brain tumor cells--involvement of a cAMP responsive element-like promoter sequence and a protein kinase A signaling pathway.
Brain Neoplasms
Targeting DNA-PKcs and telomerase in brain tumour cells.
Brain Neoplasms
The DNA-PK inhibitor VX-984 enhances the radiosensitivity of glioblastoma cells grown in vitro and as orthotopic xenografts.
Brain Stem Neoplasms
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.
Breast Diseases
14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling.
Breast Diseases
Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells.
Breast Diseases
Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA.
Breast Diseases
Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.
Breast Diseases
Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients.
Breast Neoplasms
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Breast Neoplasms
14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling.
Breast Neoplasms
3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but akt-independent manner.
Breast Neoplasms
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.
Breast Neoplasms
4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis.
Breast Neoplasms
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
Breast Neoplasms
9-Hydroxypheophorbide alpha-induced apoptotic death of MCF-7 breast cancer cells is mediated by c-Jun N-terminal kinase activation.
Breast Neoplasms
A 20-year perspective on the International Fanconi Anemia Registry (IFAR).
Breast Neoplasms
A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.
Breast Neoplasms
A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.
Breast Neoplasms
A case of Peutz-Jeghers syndrome with breast cancer, bilateral sex cord tumor with annular tubules, and adenoma malignum caused by STK11 gene mutation.
Breast Neoplasms
A cis and trans adenine-dependent hairpin ribozyme against Tpl-2 target.
Breast Neoplasms
A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer.
Breast Neoplasms
A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer.
Breast Neoplasms
A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ER?-positive breast cancer cells.
Breast Neoplasms
A Novel Approach for Overcoming Drug Resistance in Breast Cancer Chemotherapy by Targeting new Synthetic Curcumin Analogues Against Aldehyde Dehydrogenase 1 (ALDH1A1) and Glycogen Synthase Kinase-3 ? (GSK-3?).
Breast Neoplasms
A Novel Cancer Testis Antigen, A-Kinase Anchor Protein 4 (AKAP4) Is a Potential Biomarker for Breast Cancer.
Breast Neoplasms
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Breast Neoplasms
A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/?-catenin signaling in breast cancer.
Breast Neoplasms
A novel PAK4-CEBPB-CLDN4 axis involving in breast cancer cell migration and invasion.
Breast Neoplasms
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines.
Breast Neoplasms
A Ser49Cys variant in the ataxia telangiectasia, mutated, gene that is more common in patients with breast carcinoma compared with population controls.
Breast Neoplasms
A study of over 35,000 women with breast cancer tested with a 25-gene panel of hereditary cancer genes.
Breast Neoplasms
A systematic review of the prevalence of DNA damage response gene mutations in prostate cancer.
Breast Neoplasms
A vector-based short hairpin RNA targeting Aurora A inhibits breast cancer growth.
Breast Neoplasms
A-kinase anchor protein 12 (AKAP12) inhibits cell migration in breast cancer.
Breast Neoplasms
A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells.
Breast Neoplasms
Aberrant methylation profile of 14-3-3 sigma and its reduced transcription/expression levels in Chinese sporadic female breast carcinogenesis.
Breast Neoplasms
Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer.
Breast Neoplasms
Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients.
Breast Neoplasms
Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats.
Breast Neoplasms
Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
Breast Neoplasms
Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.
Breast Neoplasms
Activation of the mTOR signaling pathway in breast cancer and its correlation with the clinicopathologic variables.
Breast Neoplasms
Adenovirus-mediated Aurora A shRNA driven by stathmin promoter suppressed tumor growth and enhanced paclitaxel chemotherapy sensitivity in human breast carcinoma cells.
Breast Neoplasms
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization.
Breast Neoplasms
Advancements of antisense oligonucleotides in treatment of breast cancer.
Breast Neoplasms
Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers.
Breast Neoplasms
AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-?B signaling pathway.
Breast Neoplasms
Akt regulates RSK2 to alter phosphorylation level of H2A.X in breast cancer.
Breast Neoplasms
Akt-Induced Tamoxifen Resistance is Associated with Altered FKHR Regulation.
Breast Neoplasms
AKT-ing out: SGK kinases come to the fore.
Breast Neoplasms
AKT-mediated regulation of chromatin ubiquitylation and tumorigenesis through Mel18 phosphorylation.
Breast Neoplasms
Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.
Breast Neoplasms
Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
Breast Neoplasms
Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth.
Breast Neoplasms
Alteration in the agonist/antagonist balance of antiestrogens by activation of protein kinase A signaling pathways in breast cancer cells: antiestrogen selectivity and promoter dependence.
Breast Neoplasms
Alterations of microRNAs are associated with impaired growth of MCF-7 breast cancer cells induced by inhibition of casein kinase 2.
Breast Neoplasms
Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.
Breast Neoplasms
An evaluation of prognostic value of death-associated protein kinase 1 in breast cancer.
Breast Neoplasms
An In Vivo Study for Targeted Delivery of Curcumin in Human Triple Negative Breast Carcinoma Cells Using Biocompatible PLGA Microspheres Conjugated with Folic Acid.
Breast Neoplasms
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling.
Breast Neoplasms
Analysis of Cell-type Specific Expression of CK1{varepsilon} in Various Tissues of Young Adult BALB/c Mice and in Mammary Tumors of SV40 T-Ag Transgenic Mice.
Breast Neoplasms
Analysis of MiR-195 and MiR-497 Expression, Regulation and Role in Breast Cancer.
Breast Neoplasms
AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter.
Breast Neoplasms
Androgen stimulates mitogen-activated protein kinase in human breast cancer cells.
Breast Neoplasms
Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway.
Breast Neoplasms
Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells.
Breast Neoplasms
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Breast Neoplasms
Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha.
Breast Neoplasms
Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk.
Breast Neoplasms
Antiproliferative effects of selective cyclooxygenase-2 inhibitor modulated by nimotuzumab in estrogen-dependent breast cancer cells.
Breast Neoplasms
Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.
Breast Neoplasms
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Breast Neoplasms
Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.
Breast Neoplasms
Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities.
Breast Neoplasms
Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway.
Breast Neoplasms
Are polymorphisms of the ataxia telangiectasia mutated gene associated with breast cancer risk?
Breast Neoplasms
Assessment of Aurora A kinase expression in breast cancer: a tool for early diagnosis?
Breast Neoplasms
Assessment of the role of translationally controlled tumor protein 1 (TPT1/TCTP) in breast cancer susceptibility and ATM signaling.
Breast Neoplasms
Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females.
Breast Neoplasms
Association between ATM polymorphisms and cancer risk: a meta-analysis.
Breast Neoplasms
Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients.
Breast Neoplasms
Association between polymorphisms of the ataxia telangiectasia mutated gene and breast cancer risk: evidence from the current studies.
Breast Neoplasms
Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.
Breast Neoplasms
Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast cancer cells.
Breast Neoplasms
Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression.
Breast Neoplasms
Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients.
Breast Neoplasms
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.
Breast Neoplasms
ATM Expression Is Elevated in Established Radiation-Resistant Breast Cancer Cells and Improves DNA Repair Efficiency.
Breast Neoplasms
Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.
Breast Neoplasms
ATM kinase regulates tumor immunoreactions in lymphocyte-predominant breast cancer through modulation of NKG2D ligand and TNF cytokines on tumor cells.
Breast Neoplasms
ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations.
Breast Neoplasms
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition.
Breast Neoplasms
Attenuation of ERK/RSK2-Driven NF?B Gene Expression and Cancer Cell Proliferation by Kurarinone, a Lavandulyl Flavanone Isolated from Sophora flavescens Ait. Roots.
Breast Neoplasms
Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer.
Breast Neoplasms
Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers.
Breast Neoplasms
Aurora A overexpression in breast cancer patients induces taxane resistance and results in worse prognosis.
Breast Neoplasms
Aurora B induces epithelial-mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis.
Breast Neoplasms
Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer.
Breast Neoplasms
Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ER? expression in initially ER?+ breast cancer cells.
Breast Neoplasms
Autocrine signalling through erbB receptors promotes constitutive activation of protein kinase B/Akt in breast cancer cell lines.
Breast Neoplasms
BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 phase.
Breast Neoplasms
Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression.
Breast Neoplasms
BMP-2 upregulates the AKT/mTOR pathway in breast cancer with microcalcification and indicates a poor prognosis.
Breast Neoplasms
Body fatness and mTOR pathway activation of breast cancer in the Women's Circle of Health Study.
Breast Neoplasms
BRCA1 and BRCA2 mutations and treatment strategies for breast cancer.
Breast Neoplasms
Breast Cancer Cells Proliferation Is Regulated by Tyrosine Phosphatase SHP1 through c-jun N-Terminal Kinase and Cooperative Induction of RFX-1 and AP-4 Transcription Factors.
Breast Neoplasms
Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status.
Breast Neoplasms
Breast cancer risk and germline genomic profiling of women with neurofibromatosis type 1 who developed breast cancer.
Breast Neoplasms
Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility.
Breast Neoplasms
Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.
Breast Neoplasms
Breast cancer susceptibility: current knowledge and implications for genetic counselling.
Breast Neoplasms
Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.
Breast Neoplasms
Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology.
Breast Neoplasms
Bromelain-Induced Apoptosis in GI-101A Breast Cancer Cells.
Breast Neoplasms
BUB1 promotes proliferation of liver cancer cells by activating SMAD2 phosphorylation.
Breast Neoplasms
Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways.
Breast Neoplasms
C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer.
Breast Neoplasms
c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells.
Breast Neoplasms
c-Jun N-terminal kinase inactivation by mitogen-activated protein kinase phosphatase 1 determines resistance to taxanes and anthracyclines in breast cancer.
Breast Neoplasms
c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.
Breast Neoplasms
C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer.
Breast Neoplasms
Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers.
Breast Neoplasms
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
Breast Neoplasms
Cantharidin Induces DNA Damage and Inhibits DNA Repair-associated Protein Expressions in TSGH8301 Human Bladder Cancer Cell.
Breast Neoplasms
Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells.
Breast Neoplasms
Casein Kinase 1? Is a Potential Therapeutic Target in Breast Cancer.
Breast Neoplasms
Casein kinase 1? promotes cell proliferation by regulating mRNA translation.
Breast Neoplasms
Casein Kinase I epsilon positively regulates the Akt pathway in breast cancer cell lines.
Breast Neoplasms
Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila.
Breast Neoplasms
Caspase-dependent and caspase-independent induction of apoptosis in breast cancer by fucoidan via the PI3K/AKT/GSK3? pathway in vivo and in vitro.
Breast Neoplasms
Casticin inhibits breast cancer cell migration and invasion by down-regulation of PI3K/Akt signaling pathway.
Breast Neoplasms
CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.
Breast Neoplasms
Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours.
Breast Neoplasms
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Breast Neoplasms
CG0009, a novel glycogen synthase kinase 3 inhibitor, induces cell death through cyclin D1 depletion in breast cancer cells.
Breast Neoplasms
Changes in messenger RNA expression of protein kinase A regulatory subunit ialpha in breast cancer patients treated with tamoxifen.
Breast Neoplasms
Characterization and hormonal regulation of casein kinase II activity in heterotransplanted human breast tumors in nude mice.
Breast Neoplasms
Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer.
Breast Neoplasms
Characterization of the expression and prognostic value of 14-3-3 isoforms in breast cancer.
Breast Neoplasms
Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients.
Breast Neoplasms
Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer.
Breast Neoplasms
Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer.
Breast Neoplasms
Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819.
Breast Neoplasms
Chk1 suppression leads to a reduction in the enhanced radiation-induced invasive capability on breast cancer cells.
Breast Neoplasms
Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells.
Breast Neoplasms
Circular RNA VRK1 correlates with favourable prognosis, inhibits cell proliferation but promotes apoptosis in breast cancer.
Breast Neoplasms
CK1epsilon is required for breast cancers dependent on beta-catenin activity.
Breast Neoplasms
CK1{delta} modulates the transcriptional activity of ER{alpha} via AIB1 in an estrogen-dependent manner and regulates ER{alpha}-AIB1 interactions.
Breast Neoplasms
Clinical and biological significance of GSK-3beta inactivation in breast cancer-an immunohistochemical study.
Breast Neoplasms
Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis.
Breast Neoplasms
Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer.
Breast Neoplasms
Clinical Implications of the Progression-Free Survival Endpoint for Treatment of Hormone Receptor-Positive Advanced Breast Cancer.
Breast Neoplasms
Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies.
Breast Neoplasms
Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
Breast Neoplasms
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.
Breast Neoplasms
Co-treatment of LY294002 or MK-2206 with AZD5363 Attenuates AZD5363-induced Increase in the Level of Phosphorylated AKT.
Breast Neoplasms
Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells.
Breast Neoplasms
Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110? Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers.
Breast Neoplasms
Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer.
Breast Neoplasms
Combined bazedoxifene and paclitaxel treatments inhibit cell viability, cell migration, colony formation, and tumor growth and induce apoptosis in breast cancer.
Breast Neoplasms
Combined effect of papuamine and doxorubicin in human breast cancer MCF-7 cells.
Breast Neoplasms
Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer.
Breast Neoplasms
Combined LIM kinase 1 and p21-Activated kinase 4 inhibitor treatment exhibits potent preclinical antitumor efficacy in breast cancer.
Breast Neoplasms
Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth.
Breast Neoplasms
Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells.
Breast Neoplasms
Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.
Breast Neoplasms
Comparison of Anticancer Activity of Dorycnium pentaphyllum Extract on MCF-7 and MCF-12A Cell Line: Correlation with Invasion and Adhesion.
Breast Neoplasms
Comparison of Patient Susceptibility Genes Across Breast Cancer: Implications for Prognosis and Therapeutic Outcomes.
Breast Neoplasms
Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.
Breast Neoplasms
Computational algorithms for in silico profiling of activating mutations in cancer.
Breast Neoplasms
Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells.
Breast Neoplasms
Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis.
Breast Neoplasms
Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer.
Breast Neoplasms
Contribution of protein kinase A and protein kinase C signalling pathways to the regulation of HSD11B2 expression and proliferation of MCF-7 cells.
Breast Neoplasms
Control of centrin stability by Aurora A.
Breast Neoplasms
Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2.
Breast Neoplasms
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.
Breast Neoplasms
Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth.
Breast Neoplasms
Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancer.
Breast Neoplasms
COP1 and GSK3? Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis.
Breast Neoplasms
Correlation of epidermal growth factor receptor (EGFR), androgen receptor (AR) and 14-3-3 sigma expression in breast cancer.
Breast Neoplasms
Correlation of expression of WWOX and JNK with clinicopathologic features in human breast carcinoma.
Breast Neoplasms
Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway.
Breast Neoplasms
Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation.
Breast Neoplasms
CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.
Breast Neoplasms
Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells.
Breast Neoplasms
Curcumin Rescues Doxorubicin Responsiveness via Regulating Aurora a Signaling Network in Breast Cancer Cells.
Breast Neoplasms
Curcumin Triggers DNA Damage and Inhibits Expression of DNA Repair Proteins in Human Lung Cancer Cells.
Breast Neoplasms
Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers.
Breast Neoplasms
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
Breast Neoplasms
Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer.
Breast Neoplasms
D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells.
Breast Neoplasms
Danthron Induces DNA Damage and Inhibits DNA Repair Gene Expressions in GBM 8401 Human Brain Glioblastoma Multiforms Cells.
Breast Neoplasms
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene.
Breast Neoplasms
DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression.
Breast Neoplasms
Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis.
Breast Neoplasms
Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer.
Breast Neoplasms
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Breast Neoplasms
Delayed mammary gland involution in MMTV-AKT1 transgenic mice.
Breast Neoplasms
Delivery of Protein Kinase A by CRISPRMAX and Its Effects on Breast Cancer Stem-Like Properties.
Breast Neoplasms
Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition.
Breast Neoplasms
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
Breast Neoplasms
Detailed chromosomal characterization of the breast cancer cell line MCF7 with special focus on the expression of the serine-threonine kinase 15.
Breast Neoplasms
Detection of 14-3-3 sigma (?) promoter methylation as a noninvasive biomarker using blood samples for breast cancer diagnosis.
Breast Neoplasms
Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients.
Breast Neoplasms
Development of dual casein kinase 1?/1? (CK1?/?) inhibitors for treatment of breast cancer.
Breast Neoplasms
Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors.
Breast Neoplasms
Dickkopf-1 mediated tumor suppression in human breast carcinoma cells.
Breast Neoplasms
DIF-1 inhibits growth and metastasis of triple-negative breast cancer through AMPK-mediated inhibition of the mTORC1-S6K signaling pathway.
Breast Neoplasms
Differential gene expression profile of retinoblastoma compared to normal retina.
Breast Neoplasms
Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin.
Breast Neoplasms
Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation.
Breast Neoplasms
Discovery of a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer.
Breast Neoplasms
Discovery of Rho-kinase inhibitors by docking-based virtual screening.
Breast Neoplasms
DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs.
Breast Neoplasms
DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4.
Breast Neoplasms
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Breast Neoplasms
DOK7 Inhibits Cell Proliferation, Migration, and Invasion of Breast Cancer via the PI3K/PTEN/AKT Pathway.
Breast Neoplasms
Double Heterozygosity of BRCA2 and STK11 in Familial Breast Cancer Detected by Exome Sequencing.
Breast Neoplasms
Down-regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer.
Breast Neoplasms
Down-regulation of Raf-1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells.
Breast Neoplasms
Downregulation of 14-3-3? inhibits proliferation and migration in osteosarcoma cells.
Breast Neoplasms
Downregulation of GRK5 hampers the migration of breast cancer cells.
Breast Neoplasms
Downregulation of MicroRNA-152 and Inhibition of Cell Proliferation, Migration, and Invasion in Breast Cancer.
Breast Neoplasms
Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation.
Breast Neoplasms
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Breast Neoplasms
Effect of NUCKS-1 overexpression on cytokine profiling in obese women with breast cancer.
Breast Neoplasms
Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells.
Breast Neoplasms
Effective Targeting of Raf-1 and Its Associated Autophagy by Novel Extracted Peptide for Treating Breast Cancer Cells.
Breast Neoplasms
Effects of raf kinase inhibitor protein expression on metastasis and progression of human breast cancer.
Breast Neoplasms
Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer.
Breast Neoplasms
Effects of the activated mitogen-activated protein kinase pathway via the c-ros receptor tyrosine kinase on the T47D breast cancer cell line following alcohol exposure.
Breast Neoplasms
Effects of the novel DNA dependent protein kinase inhibitor, IC486241, on the DNA damage response to doxorubicin and cisplatin in breast cancer cells.
Breast Neoplasms
Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
Breast Neoplasms
EGFR and ErbB2 differentially regulate Raf-1 translocation and activation.
Breast Neoplasms
Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Breast Neoplasms
Endocrine therapy: defining the path of least resistance.
Breast Neoplasms
Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.
Breast Neoplasms
Enhanced effect of geldanamycin nanocomposite against breast cancer cells growing in vitro and as xenograft with vanquished normal cell toxicity.
Breast Neoplasms
Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage.
Breast Neoplasms
Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA.
Breast Neoplasms
Erratum: Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling.
Breast Neoplasms
Erratum: Zare, A. et al. RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis. Cancers, 2018, 10, 184.
Breast Neoplasms
ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells.
Breast Neoplasms
Estradiol promotes the progression of ER+ breast cancer through methylation-mediated RSK4 inactivation.
Breast Neoplasms
Estradiol suppresses phosphorylation of ER? serine 167 through upregulation of PP2A in breast cancer cells.
Breast Neoplasms
Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells.
Breast Neoplasms
Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements.
Breast Neoplasms
Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells.
Breast Neoplasms
Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians.
Breast Neoplasms
Evaluation of the contribution of the three breast cancer susceptibility genes CHEK2, STK11, and PALB2 in non-BRCA1/2 French Canadian families with high risk of breast cancer.
Breast Neoplasms
Evolving pathway-driven biomarkers in breast cancer.
Breast Neoplasms
Exceptional durable response to everolimus in a patient with biphenotypic breast cancer harboring an STK11 variant.
Breast Neoplasms
Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer.
Breast Neoplasms
Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.
Breast Neoplasms
Expression of constitutively active Akt-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo.
Breast Neoplasms
Expression of DNA-PKcs and BRCA1 as prognostic indicators in nasopharyngeal carcinoma following intensity-modulated radiation therapy.
Breast Neoplasms
Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney.
Breast Neoplasms
Exquisite antitumour response to trastuzumab in a patient with no evidence of Ras-Raf-MAPK and PI3K-Akt pathways activation.
Breast Neoplasms
Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer.
Breast Neoplasms
FADD phosphorylation is critical for cell cycle regulation in breast cancer cells.
Breast Neoplasms
Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells.
Breast Neoplasms
Focal adhesion kinase and protein kinase B cooperate to suppress Doxorubicin-induced apoptosis of breast tumor cells.
Breast Neoplasms
Formation of tissue factor-factor VIIa-factor Xa complex induces activation of the mTOR pathway which regulates migration of human breast cancer cells.
Breast Neoplasms
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.
Breast Neoplasms
Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families.
Breast Neoplasms
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma.
Breast Neoplasms
Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.
Breast Neoplasms
Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.
Breast Neoplasms
Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.
Breast Neoplasms
Functional proteomics of breast cancer for signal pathway profiling and target discovery.
Breast Neoplasms
Functional significance of Aurora kinase A regulatory interactions with p53-ER? complex in human breast cancer cells.
Breast Neoplasms
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Breast Neoplasms
G-Protein-Coupled Receptor 5 (LGR5) Overexpression Activates ?-Catenin Signaling in Breast Cancer Cells via Protein Kinase A.
Breast Neoplasms
Gallic acid induces DNA damage and inhibits DNA repair-associated protein expression in human oral cancer SCC-4 cells.
Breast Neoplasms
Gene analysis techniques and susceptibility gene discovery in non-BRCA1/BRCA2 familial breast cancer.
Breast Neoplasms
Gene expression profile by inhibiting Raf-1 protein kinase in breast cancer cells.
Breast Neoplasms
Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk.
Breast Neoplasms
Genetic testing for hereditary prostate cancer: Current status and limitations.
Breast Neoplasms
Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population.
Breast Neoplasms
Germline PALB2, ATM variants in a patient with breast and ovarian cancer at risk for familial cancer syndrome: Is there a role for risk-reducing salpingo-oophorectomy?
Breast Neoplasms
Glycogen synthase kinase-3 protects estrogen receptor alpha from proteasomal degradation and is required for full transcriptional activity of the receptor.
Breast Neoplasms
Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.
Breast Neoplasms
GPR30 expression and function in breast cancer cells are induced through a cis?acting element targeted by ETS factors.
Breast Neoplasms
Growth inhibition and antimetastatic effect of antisense poly-DNP-RNA on human breast cancer cells.
Breast Neoplasms
Growth inhibition by 8-chloro cyclic AMP of human HT29 colorectal and ZR-75-1 breast carcinoma xenografts is associated with selective modulation of protein kinase A isoenzymes.
Breast Neoplasms
Growth signaling in breast cancer cells: outcomes and promises of proteomics.
Breast Neoplasms
GSK-3 inhibition overcomes chemoresistance in human breast cancer.
Breast Neoplasms
GSK-3? Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals.
Breast Neoplasms
Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells.
Breast Neoplasms
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells.
Breast Neoplasms
Head-to-head comparison of the impact of Aurora A, Aurora B, Repp86, CDK1, CDK2 and Ki67 expression in two of the most relevant gynaecological tumor entities.
Breast Neoplasms
Heat shock protein 90 is a rational molecular target in breast cancer.
Breast Neoplasms
HER-2 Expression Correlates with Survivin in Primary Invasive Ductal Breast Cancers.
Breast Neoplasms
Hereditary breast cancer: high risk genes, genetic testing and clinical implications.
Breast Neoplasms
Hereditary breast cancer: new genetic developments, new therapeutic avenues.
Breast Neoplasms
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.
Breast Neoplasms
Heregulin regulation of Akt/protein kinase B in breast cancer cells.
Breast Neoplasms
Heregulin-?1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways.
Breast Neoplasms
High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer.
Breast Neoplasms
High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.
Breast Neoplasms
High Raf-1 kinase activity protects human tumor cells against paclitaxel-induced cytotoxicity.
Breast Neoplasms
High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.
Breast Neoplasms
Higher serum concentrations of vimentin and DAKP1 are associated with aggressive breast tumour phenotypes in Ghanaian women.
Breast Neoplasms
HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.
Breast Neoplasms
Histopathological features of breast cancer in carriers of ATM gene variants.
Breast Neoplasms
Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells.
Breast Neoplasms
Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells.
Breast Neoplasms
Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.
Breast Neoplasms
Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells.
Breast Neoplasms
Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer.
Breast Neoplasms
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms.
Breast Neoplasms
Hypoxia regulation of phosphokinases and the prognostic value of pAKT in breast cancer.
Breast Neoplasms
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.
Breast Neoplasms
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay.
Breast Neoplasms
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Breast Neoplasms
Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells.
Breast Neoplasms
Identification of Aurora Kinase A as a Biomarker for Prognosis in Obesity Patients with Early Breast Cancer.
Breast Neoplasms
Identification of differentially methylated genes as diagnostic and prognostic biomarkers of breast cancer.
Breast Neoplasms
Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.
Breast Neoplasms
Identification of key genes in glioblastoma-associated stromal cells using bioinformatics analysis.
Breast Neoplasms
Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration.
Breast Neoplasms
Identification of the potential roles of ring finger protein 8 in TP53-mutant breast cancer.
Breast Neoplasms
Identifying breast cancer subtypes associated modules and biomarkers by integrated bioinformatics analysis.
Breast Neoplasms
IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells.
Breast Neoplasms
IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells.
Breast Neoplasms
Immuno-Affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance.
Breast Neoplasms
Immunohistochemical Detection of Phospho-Akt, Phospho-BAD, HER2 and Oestrogen Receptors alpha and beta in Malaysian Breast Cancer Patients.
Breast Neoplasms
Immunohistochemical evaluation of ROCK activation in invasive breast cancer.
Breast Neoplasms
Impaired DNA Repair Fidelity in a Breast Cancer Patient With Adverse Reactions to Radiotherapy.
Breast Neoplasms
Implication of Integrin ?2?1 in Proliferation and Invasion of Human Breast Carcinoma and Melanoma Cells: Noncanonical Function of Akt Protein Kinase.
Breast Neoplasms
Improved ataxia telangiectasia mutated kinase inhibitor KU60019 provides a promising treatment strategy for non-invasive breast cancer.
Breast Neoplasms
In vivo and in vitro impact of miRNA-153 on the suppression of cell growth apoptosis through mTORC2 signaling pathway in breast cancer.
Breast Neoplasms
Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history.
Breast Neoplasms
Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line.
Breast Neoplasms
Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells.
Breast Neoplasms
Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.
Breast Neoplasms
Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.
Breast Neoplasms
Induction of ErbB-3 Expression by alpha6beta4 Integrin Contributes to Tamoxifen Resistance in ERbeta1-Negative Breast Carcinomas.
Breast Neoplasms
Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells.
Breast Neoplasms
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
Breast Neoplasms
Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT.
Breast Neoplasms
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Breast Neoplasms
Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.
Breast Neoplasms
Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of ?1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI.
Breast Neoplasms
Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells.
Breast Neoplasms
Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer.
Breast Neoplasms
Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.
Breast Neoplasms
Integration of Downstream Signals of Insulin-like Growth Factor-1 Receptor by Endoplasmic Reticulum Stress for Estrogen-Induced Growth or Apoptosis in Breast Cancer Cells.
Breast Neoplasms
Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells.
Breast Neoplasms
Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells.
Breast Neoplasms
Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells.
Breast Neoplasms
Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy.
Breast Neoplasms
Involvement of nuclear steroid/thyroid/retinoid receptors and of protein kinases in the regulation of growth and of c-erbB and retinoic acid receptor expression in MCF-7 breast cancer cells.
Breast Neoplasms
Is it possible to extract a fingerprint for early breast cancer via EEG analysis?
Breast Neoplasms
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Breast Neoplasms
Jolkinolide B inhibits proliferation or migration and promotes apoptosis of MCF-7 or BT-474 breast cancer cells by downregulating the PI3K-Akt pathway.
Breast Neoplasms
Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer.
Breast Neoplasms
Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis.
Breast Neoplasms
KiSS1-induced GPR54 signaling inhibits breast cancer cell migration and epithelial-mesenchymal transition via protein kinase D1.
Breast Neoplasms
Knockdown of A-kinase anchor protein 4 inhibits proliferation of triple-negative breast cancer cells in vitro and in vivo.
Breast Neoplasms
Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGF?/CTGF Axis.
Breast Neoplasms
KSR1 regulates BRCA1 degradation and inhibits breast cancer growth.
Breast Neoplasms
L-A03, a dihydroartemisinin derivative, promotes apoptotic cell death of human breast cancer MCF-7 cells by targeting c-Jun N-terminal kinase.
Breast Neoplasms
Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers.
Breast Neoplasms
Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells.
Breast Neoplasms
LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.
Breast Neoplasms
Liver Kinase B1-A Potential Therapeutic Target in Hormone-Sensitive Breast Cancer in Older Women.
Breast Neoplasms
LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.
Breast Neoplasms
Long non-coding RNA PTENP1 inhibits proliferation and migration of breast cancer cells via AKT and MAPK signaling pathways.
Breast Neoplasms
Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer.
Breast Neoplasms
Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HER1/HER2 tyrosine kinase inhibitor lapatinib (Tykerb) in human breast carcinoma cells.
Breast Neoplasms
Lysophosphatidic acid-RAGE axis promotes lung and mammary oncogenesis via protein kinase B and regulating tumor microenvironment.
Breast Neoplasms
MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.
Breast Neoplasms
Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells.
Breast Neoplasms
MCPH1 protein expression and polymorphisms are associated with risk of breast cancer.
Breast Neoplasms
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.
Breast Neoplasms
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Breast Neoplasms
microRNA-133a regulates the cell cycle and proliferation of breast cancer cells by targeting epidermal growth factor receptor through the EGFR/Akt signaling pathway.
Breast Neoplasms
MicroRNA-145 inhibits growth and migration of breast cancer cells through targeting oncoprotein ROCK1.
Breast Neoplasms
microRNA-152 inhibits cell proliferation, migration and invasion in breast cancer.
Breast Neoplasms
MicroRNA-204 inhibits the proliferation and metastasis of breast cancer cells by targeting PI3K/AKT pathway.
Breast Neoplasms
MicroRNA-215 acts as a tumor suppressor in breast cancer by targeting AKT serine/threonine kinase 1.
Breast Neoplasms
MicroRNA-340 inhibits invasion and metastasis by downregulating ROCK1 in breast cancer cells.
Breast Neoplasms
MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway.
Breast Neoplasms
MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions.
Breast Neoplasms
MicroRNA-based regulation of Aurora A kinase in breast cancer.
Breast Neoplasms
MicroRNA?299?5p inhibits cell metastasis in breast cancer by directly targeting serine/threonine kinase 39.
Breast Neoplasms
Migration and invasion enhancer 1 (MIEN1) is overexpressed in breast cancer and is a potential new therapeutic molecular target.
Breast Neoplasms
MiR-202 inhibits cell proliferation, invasion, and migration in breast cancer by targeting ROCK1 gene.
Breast Neoplasms
MiR-216a-5p act as a tumor suppressor, regulating the cell proliferation and metastasis by targeting PAK2 in breast cancer.
Breast Neoplasms
MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1.
Breast Neoplasms
miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1.
Breast Neoplasms
Mitogenic signal transduction in human breast cancer cells.
Breast Neoplasms
Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents.
Breast Neoplasms
Mitotic kinases as drivers of the epithelial-to-mesenchymal transition and as therapeutic targets against breast cancers.
Breast Neoplasms
MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells.
Breast Neoplasms
Molecular Mechanism of Secondary Endocrine Resistance in Luminal Breast Cancer.
Breast Neoplasms
Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells.
Breast Neoplasms
Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family.
Breast Neoplasms
Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers.
Breast Neoplasms
MRCK? Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
Breast Neoplasms
MUC1-C oncoprotein induces tamoxifen resistance in human breast cancer cells.
Breast Neoplasms
MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells.
Breast Neoplasms
Multistage Vectored siRNA Targeting Ataxia-Telangiectasia Mutated for Breast Cancer Therapy.
Breast Neoplasms
Murine Prkdc Polymorphisms Impact DNA-PKcs Function.
Breast Neoplasms
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
Breast Neoplasms
Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression.
Breast Neoplasms
Nek2 as a novel molecular target for the treatment of breast carcinoma.
Breast Neoplasms
New control of the senescence barrier in breast cancer.
Breast Neoplasms
New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.
Breast Neoplasms
No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer.
Breast Neoplasms
Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines.
Breast Neoplasms
Non-BRCA1/2 Breast Cancer Susceptibility Genes: A New Frontier with Clinical Consequences for Plastic Surgeons.
Breast Neoplasms
Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism.
Breast Neoplasms
Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer.
Breast Neoplasms
Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.
Breast Neoplasms
Novel actions of tyrphostin AG 879: inhibition of RAF-1 and HER-2 expression combined with strong antitumoral effects on breast cancer cells.
Breast Neoplasms
Novel germline STK11 variants and breast cancer phenotype identified in an Indian cohort of Peutz-Jeghers syndrome.
Breast Neoplasms
Novel interacting proteins identified by tandem affinity purification coupled to nano LC-MS/MS interact with ribosomal S6 protein kinase 4 (RSK4) and its variant protein (RSK4m).
Breast Neoplasms
Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells.
Breast Neoplasms
Nucleus-located PDK1 regulates growth, invasion and migration of breast cancer cells.
Breast Neoplasms
Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells.
Breast Neoplasms
Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.
Breast Neoplasms
Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer.
Breast Neoplasms
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.
Breast Neoplasms
Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor.
Breast Neoplasms
Overexpression of AKIP1 predicts poor prognosis of patients with breast carcinoma and promotes cancer metastasis through Akt/GSK-3?/Snail pathway.
Breast Neoplasms
Overexpression of cyclo-oxygenase-2 is an independent predictor of unfavourable outcome in node-negative breast cancer, but is not associated with protein kinase B (Akt) and mitogen-activated protein kinase (ERK1/2, p38) activation or with Her-2/neu signalling pathways.
Breast Neoplasms
Overexpression of P70 S6 kinase protein is associated with increased risk of locoregional recurrence in node-negative premenopausal early breast cancer patients.
Breast Neoplasms
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
Breast Neoplasms
Overexpression of Rho-Associated Coiled-Coil Containing Protein Kinase 2 Is Correlated with Clinical Progression and Poor Prognosis in Breast Cancer.
Breast Neoplasms
Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/Akt signaling pathway.
Breast Neoplasms
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells.
Breast Neoplasms
P21-activated kinase 4 regulates the cyclin-dependent kinase inhibitor p57(kip2) in human breast cancer.
Breast Neoplasms
P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.
Breast Neoplasms
Pak1 kinase links ErbB2 to ?-catenin in transformation of breast epithelial cells.
Breast Neoplasms
PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV.
Breast Neoplasms
PAK1 translocates into nucleus in response to prolactin but not to estrogen.
Breast Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Breast Neoplasms
PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase, a Putative Cancer/Testis Antigen with an Oncogenic Activity in Breast Cancer.
Breast Neoplasms
PET Imaging on Dynamic Metabolic Changes after Combination Therapy of Paclitaxel and the Traditional Chinese Medicine in Breast Cancer-Bearing Mice.
Breast Neoplasms
PFKFB3 is involved in breast cancer proliferation, migration, invasion and angiogenesis.
Breast Neoplasms
Phase I trial to evaluate the addition of alisertib to fulvestrant in women with endocrine-resistant, ER+ metastatic breast cancer.
Breast Neoplasms
Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling.
Breast Neoplasms
Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity.
Breast Neoplasms
Phenotypic analysis of familial breast cancer: Comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast cancer.
Breast Neoplasms
Phenotypic differentiation of human breast cancer cells by 1,3 cyclic propanediol phosphate.
Breast Neoplasms
PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.
Breast Neoplasms
Phosphorylated Akt1 in human breast cancer measured by direct sandwich enzyme-linked immunosorbent assay: Correlation with clinicopathological features and tumor VEGF-signaling system component levels.
Breast Neoplasms
Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer.
Breast Neoplasms
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells.
Breast Neoplasms
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.
Breast Neoplasms
Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells.
Breast Neoplasms
Phosphorylation stabilizes alternatively spliced CD44 mRNA transcripts in breast cancer cells: inhibition by antisense complementary to casein kinase II mRNA.
Breast Neoplasms
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects.
Breast Neoplasms
PI3K/mTOR mediate mitogen-dependent HDAC1 phosphorylation in breast cancer: a novel regulation of estrogen receptor expression.
Breast Neoplasms
Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin.
Breast Neoplasms
Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer.
Breast Neoplasms
Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression.
Breast Neoplasms
Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells.
Breast Neoplasms
PKA phosphorylation redirects ER? to promoters of a unique gene set to induce tamoxifen resistance.
Breast Neoplasms
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest.
Breast Neoplasms
PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression.
Breast Neoplasms
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors.
Breast Neoplasms
Post-Breast Cancer Radiotherapy Bronchiolitis Obliterans Organizing Pneumonia.
Breast Neoplasms
Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells.
Breast Neoplasms
Potential Anticancer Effect of Calcium-mediated Src Degradation on Hormone-dependent Breast Cancer.
Breast Neoplasms
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.
Breast Neoplasms
Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization.
Breast Neoplasms
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.
Breast Neoplasms
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival.
Breast Neoplasms
Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis.
Breast Neoplasms
Prevalence of deleterious mutations among patients with breast cancer referred for multigene panel testing in a Romanian population.
Breast Neoplasms
Pro-necrotic molecules impact local immunosurveillance in human breast cancer.
Breast Neoplasms
Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency.
Breast Neoplasms
Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells.
Breast Neoplasms
Prognostic and predictive value of p-Akt, EGFR, and p-mTOR in early breast cancer.
Breast Neoplasms
Prospecting for Breast Cancer Blood Biomarkers: Death-Associated Protein Kinase 1 (DAPK1) as a Potential Candidate.
Breast Neoplasms
Protein kinase A activation by ??Lapachone is associated with apoptotic cell death in NQO1?overexpressing breast cancer cells.
Breast Neoplasms
Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines.
Breast Neoplasms
Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration.
Breast Neoplasms
Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation.
Breast Neoplasms
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
Breast Neoplasms
Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.
Breast Neoplasms
Protein Kinase CK2 Expression Predicts Relapse Survival in ER? Dependent Breast Cancer, and Modulates ER? Expression in Vitro.
Breast Neoplasms
Protein kinase CK2 in breast cancer: the CK2? regulatory subunit takes center stage in epithelial plasticity.
Breast Neoplasms
Protein kinase CK2 promotes aberrant activation of nuclear factor-kappaB, transformed phenotype, and survival of breast cancer cells.
Breast Neoplasms
Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells.
Breast Neoplasms
Protein kinase D1 inhibits breast cancer cell invasion via regulating matrix metalloproteinase expression.
Breast Neoplasms
Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex.
Breast Neoplasms
Protein kinase D1 regulates ER?-positive breast cancer cell growth response to 17?-estradiol and contributes to poor prognosis in patients.
Breast Neoplasms
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion.
Breast Neoplasms
Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway.
Breast Neoplasms
Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.
Breast Neoplasms
Proteomic analysis of ductal carcinoma of the breast using laser capture microdissection, LC-MS, and 16O/18O isotopic labeling.
Breast Neoplasms
Proteomic Analysis of Urine to Identify Breast Cancer Biomarker Candidates Using a Label-Free LC-MS/MS Approach.
Breast Neoplasms
Proteomic analysis reveals that 14-3-3sigma is down-regulated in human breast cancer cells.
Breast Neoplasms
Proteomic Changes Induced by Effective Chemopreventive Ratios of n-3:n-6 Fatty Acids and Tamoxifen against MNU-Induced Mammary Cancer in the Rat.
Breast Neoplasms
Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID?
Breast Neoplasms
Proteomics of breast cancer for marker discovery and signal pathway profiling.
Breast Neoplasms
Proteomics of breast cancer: outcomes and prospects.
Breast Neoplasms
Proteomics-derived basal biomarker DNA-PKcs is associated with intrinsic subtype and long-term clinical outcomes in breast cancer.
Breast Neoplasms
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
Breast Neoplasms
PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation.
Breast Neoplasms
PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.
Breast Neoplasms
PTH-related protein upregulates integrin alpha6beta4 expression and activates Akt in breast cancer cells.
Breast Neoplasms
QLT0267, a small molecule inhibitor targeting Integrin-Linked Kinase (ILK), and Docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model.
Breast Neoplasms
Quercetin Increase the Chemosensitivity of Breast Cancer Cells to Doxorubicin via PTEN/Akt Pathway.
Breast Neoplasms
Quinazolino linked 4?-amidopodophyllotoxin conjugates regulate angiogenic pathway and control breast cancer cell proliferation.
Breast Neoplasms
Radiographic Surveillance of Patients with Non-BRCA1/2 Pathogenic Variants.
Breast Neoplasms
Raf kinase inhibitory protein role in the molecular subtyping of breast cancer.
Breast Neoplasms
Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance.
Breast Neoplasms
Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells.
Breast Neoplasms
Raf-1 protein expression in human breast cancer cells.
Breast Neoplasms
Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients.
Breast Neoplasms
Receptor tyrosine kinase EphB4 is a survival factor in breast cancer.
Breast Neoplasms
Recommendations for Preventive Care for Women with Rare Genetic Cause of Breast and Ovarian Cancer.
Breast Neoplasms
Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition.
Breast Neoplasms
Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen.
Breast Neoplasms
Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis.
Breast Neoplasms
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.
Breast Neoplasms
Regulated association of protein kinase B/Akt with breast tumor kinase.
Breast Neoplasms
Regulation and localization of ribosomal protein S6 kinase 1 isoforms.
Breast Neoplasms
Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function.
Breast Neoplasms
Regulation of GPR54 Signaling by GRK2 and {beta}-Arrestin.
Breast Neoplasms
Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.
Breast Neoplasms
Regulation of ROCK1 via Notch1 during breast cancer cell migration into dense matrices.
Breast Neoplasms
Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3? signaling pathway.
Breast Neoplasms
Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.
Breast Neoplasms
Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling.
Breast Neoplasms
Retinoids increase cell-cell adhesion strength, beta-catenin protein stability, and localization to the cell membrane in a breast cancer cell line: a role for serine kinase activity.
Breast Neoplasms
Retraction: Targeting 3-Phosphoinoside-Dependent Kinase-1 to Inhibit Insulin-Like Growth Factor-I Induced AKT and p70 S6 Kinase Activation in Breast Cancer Cells.
Breast Neoplasms
Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels.
Breast Neoplasms
RIalpha Influences Cellular Proliferation in Cancer Cells by Transporting RFC40 into the Nucleus.
Breast Neoplasms
RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis.
Breast Neoplasms
ROCK1 Inhibition Promotes the Self-Renewal of a Novel Mouse Mammary Cancer Stem Cell.
Breast Neoplasms
ROCKII Ser1366 phosphorylation reflects the activation status.
Breast Neoplasms
Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.
Breast Neoplasms
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Breast Neoplasms
Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells.
Breast Neoplasms
Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases.
Breast Neoplasms
Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair.
Breast Neoplasms
Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells.
Breast Neoplasms
Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer.
Breast Neoplasms
Roscovitine and Trichostatin A promote DNA damage repair during porcine oocyte maturation.
Breast Neoplasms
RSK-mediated down-regulation of PDCD4 is required for proliferation, survival, and migration in a model of triple-negative breast cancer.
Breast Neoplasms
Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells.
Breast Neoplasms
San Huang Decoction downregulates Aurora kinase A to inhibit breast cancer cell growth and enhance chemosenstivity to anti-tumor drugs.
Breast Neoplasms
Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer.
Breast Neoplasms
Screening breast cancer patients for Norwegian ATM mutations.
Breast Neoplasms
Screening for ATM sequence alterations in African-American women diagnosed with breast cancer.
Breast Neoplasms
Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death.
Breast Neoplasms
Selective modulation of protein kinase A and protein kinase C activities in epidermal growth factor (EGF)-stimulated MCF-7 breast cancer cells.
Breast Neoplasms
Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.
Breast Neoplasms
Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions.
Breast Neoplasms
Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
Breast Neoplasms
Silencing Aurora A leads to re-sensitization of breast cancer cells to Taxol through downregulation of SRC-mediated ERK and mTOR pathways.
Breast Neoplasms
Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells.
Breast Neoplasms
Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway.
Breast Neoplasms
SIRT1 promotes formation of breast cancer through modulating Akt activity.
Breast Neoplasms
SNPs within microRNA binding sites and the prognosis of breast cancer.
Breast Neoplasms
Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway.
Breast Neoplasms
Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.
Breast Neoplasms
Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis.
Breast Neoplasms
Specific Roles of HSP27 S15 Phosphorylation Augmenting the Nuclear Function of HER2 to Promote Trastuzumab Resistance.
Breast Neoplasms
Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection.
Breast Neoplasms
Src tyrosyl phosphorylates cortactin in response to prolactin.
Breast Neoplasms
Stimulation or endothelin-1 secretion by human breast cancer cells through protein kinase A activation: a possible novel paracrine loop involving breast fibroblast-derived prostaglandin E2.
Breast Neoplasms
STK11 loss drives rapid progression in a breast cancer patient resulting in pulmonary tumor thrombotic microangiopathy.
Breast Neoplasms
STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation.
Breast Neoplasms
Structure meets function--centrosomes, genome maintenance and the DNA damage response.
Breast Neoplasms
Study of promoter methylation pattern of 14-3-3 sigma gene in normal and cancerous tissue of breast: A potential biomarker for detection of breast cancer in patients.
Breast Neoplasms
Study on correlation between PKIB and pAkt expression in breast cancer tissues.
Breast Neoplasms
Synergistic activation of ER? by estrogen and prolactin in breast cancer cells requires tyrosyl phosphorylation of PAK1.
Breast Neoplasms
Synergistic Interactions of 5-Fluorouracil with Inhibitors of Protein Kinase CK2 Correlate with p38 MAPK Activation and FAK Inhibition in the Triple-Negative Breast Cancer Cell Line.
Breast Neoplasms
Systems consequences of amplicon formation in human breast cancer.
Breast Neoplasms
TACC1-chTOG-Aurora A protein complex in breast cancer.
Breast Neoplasms
Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function.
Breast Neoplasms
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity.
Breast Neoplasms
Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells.
Breast Neoplasms
Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy.
Breast Neoplasms
Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines.
Breast Neoplasms
Targeting dna double strand break repair with hyperthermia and dna-pkcs inhibition to enhance the effect of radiation treatment.
Breast Neoplasms
Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers.
Breast Neoplasms
Targeting on glycosylation of mutant FLT3 in acute myeloid leukemia.
Breast Neoplasms
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
Breast Neoplasms
Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells.
Breast Neoplasms
Targeting the PI3K/Akt/mTOR-pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases.
Breast Neoplasms
Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence.
Breast Neoplasms
The ?-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein-coupled receptor lysosomal sorting and signaling.
Breast Neoplasms
The Ataxia-telangiectasia mutated gene and breast cancer: gene expression profiles and sequence variants.
Breast Neoplasms
The AURORA initiative for metastatic breast cancer.
Breast Neoplasms
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin.
Breast Neoplasms
The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.
Breast Neoplasms
The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.
Breast Neoplasms
The dual PI3K/mTOR-pathway inhibitor GDC-0084 achieves antitumor activity in PIK3CA-mutant breast cancer brain metastases.
Breast Neoplasms
The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
Breast Neoplasms
The expression and prognosis of Emi1 and Skp2 in breast carcinoma: associated with PI3K/Akt pathway and cell proliferation.
Breast Neoplasms
The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.
Breast Neoplasms
The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer.
Breast Neoplasms
The interaction of p130Cas with PKN3 promotes malignant growth.
Breast Neoplasms
The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.
Breast Neoplasms
The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway.
Breast Neoplasms
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ER?(+) breast cancer cells.
Breast Neoplasms
The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.
Breast Neoplasms
The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line.
Breast Neoplasms
The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells.
Breast Neoplasms
The prevalence of ataxia telangiectasia mutated (ATM) variants in patients with breast cancer patients: a systematic review and meta-analysis.
Breast Neoplasms
The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas.
Breast Neoplasms
The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing.
Breast Neoplasms
The role and regulatory mechanism of 14-3-3 sigma in human breast cancer.
Breast Neoplasms
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
Breast Neoplasms
The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents.
Breast Neoplasms
The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line.
Breast Neoplasms
The Roles of 4?-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells.
Breast Neoplasms
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.
Breast Neoplasms
The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.
Breast Neoplasms
Therapeutic targeting of casein kinase 1? in breast cancer.
Breast Neoplasms
Time Trends in Receipt of Germline Genetic Testing and Results for Women Diagnosed With Breast Cancer or Ovarian Cancer, 2012-2019.
Breast Neoplasms
Tissue-Specific Warburg Effect in Breast Cancer and Cancer-Associated Adipose Tissue-Relationship between AMPK and Glycolysis.
Breast Neoplasms
TM4SF4 and LRRK2 are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis.
Breast Neoplasms
TMEM17 promotes malignant progression of breast cancer via AKT/GSK3? signaling.
Breast Neoplasms
Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.
Breast Neoplasms
Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes.
Breast Neoplasms
Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients.
Breast Neoplasms
Tumorigenesis and neurodegeneration: two sides of the same coin?
Breast Neoplasms
Tumour suppressor PTEN regulates cell cycle and protein kinase B/Akt pathway in breast cancer cells.
Breast Neoplasms
Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.
Breast Neoplasms
Understanding h-prune biology in the fight against cancer.
Breast Neoplasms
Upregulated PFTK1 promotes tumor cell proliferation, migration, and invasion in breast cancer.
Breast Neoplasms
Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1.
Breast Neoplasms
Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling.
Breast Neoplasms
Use of serological proteomic methods to find biomarkers associated with breast cancer.
Breast Neoplasms
Validation of a Phosphoprotein Array Assay for Characterization of Human Tyrosine Kinase Receptor Downstream Signaling in Breast Cancer.
Breast Neoplasms
Validation of the cell cycle G(2) delay assay in assessing ionizing radiation sensitivity and breast cancer risk.
Breast Neoplasms
Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.
Breast Neoplasms
Variation of ATM Gene Expression in Peripheral Blood Cells of Sporadic Breast Carcinomas in Iranian Patients.
Breast Neoplasms
Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1.
Breast Neoplasms
Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles.
Breast Neoplasms
Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies.
Breast Neoplasms
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.
Breast Neoplasms
YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells.
Breast Neoplasms
ZKSCAN3 promotes breast cancer cell proliferation, migration and invasion.
Breast Neoplasms
[Ataxia-telangiectasia mutated gene and breast cancer susceptibility]
Breast Neoplasms
[Correlation of p38 mitogen-activated protein kinase signal transduction pathway to uPA expression in breast cancer]
Breast Neoplasms
[Implications of genetic risk factors in breast cancer: culprit genes and associated malignancies]
Breast Neoplasms
[miR-153-3p inhibits proliferation and migration of breast cancer cells via down-regulating ROCK1].
Bronchitis
Coronavirus interactions with the cellular autophagy machinery.
Bulbo-Spinal Atrophy, X-Linked
Association of spinal and bulbar muscular atrophy with myotonic dystrophy type 1.
Burkitt Lymphoma
Epigenetic changes in the DAP-kinase CpG island in pediatric lymphoma.
Burkitt Lymphoma
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.
Burkitt Lymphoma
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1.
Burkitt Lymphoma
Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3.
Burkitt Lymphoma
Molecular properties, substrate specificity and regulation of DNA-dependent protein kinase from Raji Burkitt's lymphoma cells.
Burkitt Lymphoma
Signal transduction pathways in Burkitt's lymphoma cell lines BL41 and DG75 with different sensitivity to doxorubicin.
Burkitt Lymphoma
[Expression of p-AKT and p-mTOR in pediatric Burkitt lymphoma and their correlation with prognosis].
Calcinosis
BMP-2 upregulates the AKT/mTOR pathway in breast cancer with microcalcification and indicates a poor prognosis.
Candidiasis
A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient.
Candidiasis
Candida albicans protein kinase CK2 governs virulence during oropharyngeal candidiasis.
Candidiasis
Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis.
Capsule Opacification
Effect of H-7 on Secondary Cataract After Phacoemulsification in the Live Rabbit Eye.
Carcinogenesis
14-3-3 beta in the healthy and diseased male reproductive system.
Carcinogenesis
14-3-3 Proteins Modulate the ETS Transcription Factor ETV1 in Prostate Cancer.
Carcinogenesis
14-3-3 proteins: do they have a role in human cancer?
Carcinogenesis
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
Carcinogenesis
14-3-3, an integrator of cell mechanics and cytokinesis.
Carcinogenesis
14-3-3? regulates the proliferation of glioma cells through the GSK3?/?-catenin signaling pathway.
Carcinogenesis
2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1.
Carcinogenesis
6-Bromoindirubin-3'-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver.
Carcinogenesis
A Functional Copy-Number Variation in MAPKAPK2 Predicts Risk and Prognosis of Lung Cancer.
Carcinogenesis
A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity.
Carcinogenesis
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.
Carcinogenesis
A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation.
Carcinogenesis
A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206.
Carcinogenesis
A-Kinase Anchoring Proteins 10 Expression in Relation to 2073A/G Polymorphism and Tumor Progression in Patients with Colorectal Cancer.
Carcinogenesis
Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia.
Carcinogenesis
Aberrant methylation profile of 14-3-3 sigma and its reduced transcription/expression levels in Chinese sporadic female breast carcinogenesis.
Carcinogenesis
Ablation of AMPK-Related Kinase MPK38/MELK Leads to Male-Specific Obesity in Aged Mature Adult Mice.
Carcinogenesis
Activated Akt-1 in specific cell populations during multi-stage skin carcinogenesis.
Carcinogenesis
Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study.
Carcinogenesis
Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion.
Carcinogenesis
Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma.
Carcinogenesis
Activation of phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling and the consequent induction of transformation by overexpressed 14-3-3? protein require specific amino acids within 14-3-3? N-terminal variable region II.
Carcinogenesis
Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia.
Carcinogenesis
Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice.
Carcinogenesis
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization.
Carcinogenesis
Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1.
Carcinogenesis
Advances in understanding the molecular underpinnings of adrenocortical tumors.
Carcinogenesis
Alterations of beta- and gamma-catenin in N-butyl-N-(-4-hydroxybutyl)nitrosamine-induced murine bladder cancer.
Carcinogenesis
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
Carcinogenesis
AMPKalpha2 Regulates Bladder Cancer Growth Through SKP2-mediated Degradation of p27.
Carcinogenesis
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Carcinogenesis
An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.
Carcinogenesis
Analysis and prediction of pathways in HeLa cells by integrating biological levels of organization with systems-biology approaches.
Carcinogenesis
Analysis of calcium-dependent protein kinase C isoforms in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis.
Carcinogenesis
Analysis of signaling protein kinases in human colon or colorectal carcinomas.
Carcinogenesis
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Carcinogenesis
ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis.
Carcinogenesis
ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis.
Carcinogenesis
Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis.
Carcinogenesis
Association of chromosome 19 to lung cancer genotypes and phenotypes.
Carcinogenesis
Association of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung Cancer.
Carcinogenesis
ATM may be a protective factor in endometrial carcinogenesis with the progesterone pathway.
Carcinogenesis
Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia.
Carcinogenesis
Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers.
Carcinogenesis
Aurora A is essential for early embryonic development and tumor suppression.
Carcinogenesis
Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Carcinogenesis
Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor.
Carcinogenesis
Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors.
Carcinogenesis
Aurora kinase inhibitors as anti-cancer therapy.
Carcinogenesis
Aurora kinases link chromosome segregation and cell division to cancer susceptibility.
Carcinogenesis
Aurora-A kinase: a novel target both for cellular immunotherapy and molecular target therapy against human leukemia.
Carcinogenesis
Aurora-A kinase: a novel target of cellular immunotherapy for leukemia.
Carcinogenesis
Aurora-A regulates autophagy through the Akt pathway in human prostate cancer.
Carcinogenesis
Beyond DNA Repair: DNA-PKcs in Tumor Metastasis, Metabolism and Immunity.
Carcinogenesis
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.
Carcinogenesis
Biology of Aurora A kinase: Implications in cancer manifestation and therapy.
Carcinogenesis
Breaking up is hard to do: RalA, mitochondrial fission and cancer.
Carcinogenesis
c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells.
Carcinogenesis
C-terminal binding: An expanded repertoire and function of 14-3-3 proteins.
Carcinogenesis
Cancer risk from low dose radiation in Ptch1+/- mice with inactive DNA repair systems: Therapeutic implications for medulloblastoma.
Carcinogenesis
Casein kinase 2 inhibitor CX-4945 elicits an anti-Warburg effects through the downregulation of TAp73 and inhibits gastric tumorigenesis.
Carcinogenesis
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.
Carcinogenesis
CDK11p58 inhibits ER?-positive breast cancer invasion by targeting integrin ?3 via the repression of ER? signaling.
Carcinogenesis
Cell-permeable carboxyl-terminal p27(Kip1) peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase.
Carcinogenesis
Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.
Carcinogenesis
Characterization of proteins secreted by pancreatic cancer cells with anticancer drug treatment in vitro.
Carcinogenesis
Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients.
Carcinogenesis
Checkpoint Kinase 1 Is Overexpressed during HPV16-Induced Cervical Carcinogenesis.
Carcinogenesis
Chemically induced degradation of CK2 by proteolysis targeting chimeras based on a ubiquitin-proteasome pathway.
Carcinogenesis
Chemoprevention with Protein Kinase A RI{alpha} Antisense in DMBA-Mammary Carcinogenesis.
Carcinogenesis
Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding.
Carcinogenesis
Choline kinase: an important target for cancer.
Carcinogenesis
CK2-NCoR signaling cascade promotes prostate tumorigenesis.
Carcinogenesis
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Carcinogenesis
Clinical significance of 14-3-3 zeta in human esophageal cancer.
Carcinogenesis
Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer.
Carcinogenesis
Close localization of DAP-kinase positive tumour-associated macrophages and apoptotic colorectal cancer cells.
Carcinogenesis
Co-Upregulation of 14-3-3? and P-Akt is Associated with Oncogenesis and Recurrence of Hepatocellular Carcinoma.
Carcinogenesis
Combined blockade of AKT/mTOR pathway inhibits growth of human hemangioma via downregulation of proliferating cell nuclear antigen.
Carcinogenesis
Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways.
Carcinogenesis
Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.
Carcinogenesis
Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas.
Carcinogenesis
Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.
Carcinogenesis
Correlation between Aurora-A expression and the prognosis of cervical carcinoma patients.
Carcinogenesis
Correlation between homeodomain-interacting protein kinase 2 and apoptosis in cervical cancer.
Carcinogenesis
Correlation of epidermal growth factor receptor (EGFR), androgen receptor (AR) and 14-3-3 sigma expression in breast cancer.
Carcinogenesis
CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy.
Carcinogenesis
Critical role of CDK11(p58) in human breast cancer growth and angiogenesis.
Carcinogenesis
Crosstalk between GSK-3, c-Fos, NF?B and TNF-? signaling pathways play an ambitious role in Chitosan Nanoparticles Cancer Therapy.
Carcinogenesis
CSNK2A1 Promotes Gastric Cancer Invasion Through the PI3K-Akt-mTOR Signaling Pathway.
Carcinogenesis
Current overview of the role of Akt in cancer studies via applied immunohistochemistry.
Carcinogenesis
Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2.
Carcinogenesis
CX-F9, a novel RSK2 inhibitor, suppresses cutaneous melanoma cells proliferation and metastasis through regulating autophagy.
Carcinogenesis
CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression.
Carcinogenesis
Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.
Carcinogenesis
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Carcinogenesis
Decreased expression of 14-3-3 ?, an early event of malignant transformation of respiratory epithelium, also facilitates progression of squamous cell lung cancer.
Carcinogenesis
Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis.
Carcinogenesis
Deficiency of IKK? inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
Carcinogenesis
Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics.
Carcinogenesis
Detection of 14-3-3 sigma (?) promoter methylation as a noninvasive biomarker using blood samples for breast cancer diagnosis.
Carcinogenesis
Development of a FRET biosensor with high specificity for Akt.
Carcinogenesis
DIAPH3 promotes the tumorigenesis of lung adenocarcinoma.
Carcinogenesis
Differential regulation of AKT1 contributes to survival and proliferation in hepatocellular carcinoma cells by mediating Notch1 expression.
Carcinogenesis
Differentially expressed genes in giant cell tumor of bone.
Carcinogenesis
Discovery of driver non-coding splice-site-creating mutations in cancer.
Carcinogenesis
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis.
Carcinogenesis
DNA Damage-Induced Protein 14-3-3 {sigma} Inhibits Protein Kinase B/Akt Activation and Suppresses Akt-Activated Cancer.
Carcinogenesis
Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: Suppression of serine/threonine and tyrosine kinases.
Carcinogenesis
Down-regulation of 14-3-3 zeta sensitizes human glioblastoma cells to apoptosis induction.
Carcinogenesis
Down-regulation of TRAF4 targeting RSK4 inhibits proliferation, invasion and metastasis in breast cancer xenografts.
Carcinogenesis
Downregulation of GLUT3 impairs STYK1/NOK-mediated metabolic reprogramming and proliferation in NIH-3T3 cells.
Carcinogenesis
Downregulation of PIM1 regulates glycolysis and suppresses tumor progression in gallbladder cancer.
Carcinogenesis
Drug design by machine-trained elastic networks: predicting Ser/Thr-protein kinase inhibitors' activities.
Carcinogenesis
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: the role of GSK-3beta in the maintenance of steady-state levels of insulin receptor signaling molecules and Na(v)1.7 sodium channel in adrenal chromaffin cells.
Carcinogenesis
Dysregulated PTEN-PKB and negative receptor status in human breast cancer.
Carcinogenesis
Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase.
Carcinogenesis
Dysregulation of GSK3?-Target Proteins in Skin Fibroblasts of Myotonic Dystrophy Type 1 (DM1) Patients.
Carcinogenesis
Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase.
Carcinogenesis
Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.
Carcinogenesis
Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells.
Carcinogenesis
Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
Carcinogenesis
Emerging Therapeutic Implications of STK11 Mutation: Case Series.
Carcinogenesis
Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response.
Carcinogenesis
Endometriosis-associated Extraovarian Malignancies: A Challenging Question for the Clinician and the Pathologist.
Carcinogenesis
Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.
Carcinogenesis
Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.
Carcinogenesis
Estrogen receptor alpha transcriptionally activates casein kinase 2 alpha: A pivotal regulator of promyelocytic leukaemia protein (PML) and AKT in oncogenesis.
Carcinogenesis
Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways.
Carcinogenesis
Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors.
Carcinogenesis
Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C.
Carcinogenesis
Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas.
Carcinogenesis
Evolution of the multifaceted eukaryotic akirin gene family.
Carcinogenesis
Exogenous activation of LKB1/AMPK signaling induces G? arrest in cells with endogenous LKB1 expression.
Carcinogenesis
Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis.
Carcinogenesis
Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma.
Carcinogenesis
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Carcinogenesis
Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.
Carcinogenesis
Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
Carcinogenesis
Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms.
Carcinogenesis
Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage.
Carcinogenesis
Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney.
Carcinogenesis
Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.
Carcinogenesis
Expression, localization, and activity of glycogen synthase kinase 3beta during mouse skin tumorigenesis.
Carcinogenesis
Expression, purification, characterization and homology modeling of active Akt/PKB, a key enzyme involved in cell survival signaling.
Carcinogenesis
Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3.
Carcinogenesis
Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.
Carcinogenesis
Forskolin exerts anticancer roles in non-Hodgkin's lymphomas via regulating Axin/?-catenin signaling pathway.
Carcinogenesis
Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
Carcinogenesis
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity.
Carcinogenesis
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.
Carcinogenesis
Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age.
Carcinogenesis
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Carcinogenesis
Generating Conformation-Specific Polyclonal and Monoclonal Anti-Protein Kinase C Antibodies and Anti-Active State Specific PKC Antibodies.
Carcinogenesis
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Carcinogenesis
Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma.
Carcinogenesis
Genetics of Adrenocortical Development and Tumors.
Carcinogenesis
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
Carcinogenesis
GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways.
Carcinogenesis
Glycogen synthase kinase 3: more than a namesake.
Carcinogenesis
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.
Carcinogenesis
Glycogen synthase kinase-3 and leukemia: restoring the balance.
Carcinogenesis
Glycogen synthase kinase-3 phosphorylates CdGAP at a consensus ERK 1 regulatory site.
Carcinogenesis
Glycogen synthase kinase-3: functions in oncogenesis and development.
Carcinogenesis
Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy.
Carcinogenesis
GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics.
Carcinogenesis
GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.
Carcinogenesis
GSK-3: An important kinase in colon and pancreatic cancers.
Carcinogenesis
GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression.
Carcinogenesis
Helicobacter pylori induces cell migration and invasion through casein kinase 2 in gastric epithelial cells.
Carcinogenesis
Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo(-/-) mice.
Carcinogenesis
Hepatitis B virus surface proteins accelerate cholestatic injury and tumor progression in Abcb4-knockout mice.
Carcinogenesis
Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis.
Carcinogenesis
HIPK2 expression in progression of cutaneous epithelial neoplasm.
Carcinogenesis
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma.
Carcinogenesis
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Carcinogenesis
Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
Carcinogenesis
Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis.
Carcinogenesis
HPV16 E6 upregulates Aurora A expression.
Carcinogenesis
Hypomethylation of the 14-3-3? promoter leads to increased expression in non-small cell lung cancer.
Carcinogenesis
IC261, a specific inhibitor of CK1?/?, promotes aerobic glycolysis through p53-dependent mechanisms in colon cancer.
Carcinogenesis
Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.
Carcinogenesis
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay.
Carcinogenesis
Identification and molecular characterization of the Pim1 serine/threonine kinase homolog in Litopenaeus vannamei.
Carcinogenesis
Identification and validation of key genes associated with non-small-cell lung cancer.
Carcinogenesis
Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach.
Carcinogenesis
Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2.
Carcinogenesis
Identification of human hepatocellular carcinoma-related biomarkers by two-dimensional difference gel electrophoresis and mass spectrometry.
Carcinogenesis
Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif.
Carcinogenesis
Identification of nucleolar effects in JNK-deficient cells.
Carcinogenesis
Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion.
Carcinogenesis
Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis.
Carcinogenesis
Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.
Carcinogenesis
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.
Carcinogenesis
Impaired Hippo signaling promotes Rho1-JNK-dependent growth.
Carcinogenesis
Important roles of Akt/PKB signaling in the aging process.
Carcinogenesis
In vitro and in vivo assays of protein kinase CK2 activity.
Carcinogenesis
In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene.
Carcinogenesis
In vitro phosphorylation of caveolin-rich membrane domains: identification of an associated serine kinase activity as a casein kinase II-like enzyme.
Carcinogenesis
In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.
Carcinogenesis
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
Carcinogenesis
Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma.
Carcinogenesis
Increased Activated Akt Expression in Renal Cell Carcinomas and Prognosis.
Carcinogenesis
Increased expression of beta-catenin, phosphorylated glycogen synthase kinase 3beta, cyclin D1, and c-myc in laterally spreading colorectal tumors.
Carcinogenesis
Increased phospho-AKT is associated with loss of the androgen receptor during the progression of N-methyl-N-nitrosourea-induced prostate carcinogenesis in rats.
Carcinogenesis
Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer.
Carcinogenesis
Inflaming gastrointestinal oncogenic programming.
Carcinogenesis
Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.
Carcinogenesis
Infliximab inhibits DNA repair in ultraviolet B-irradiated premalignant keratinocytes.
Carcinogenesis
Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells.
Carcinogenesis
Inhibition of casein kinase II reduces TGF? induced fibroblast activation and ameliorates experimental fibrosis.
Carcinogenesis
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Carcinogenesis
Inhibition of the PI3K/AKT-NF-?B pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt's lymphoma.
Carcinogenesis
Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.
Carcinogenesis
Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation.
Carcinogenesis
Involvement of glycogen synthase kinase-3beta signaling and aberrant nucleocytoplasmic localization of retinoblastoma protein in tumor promotion in a rat two-stage thyroid carcinogenesis model.
Carcinogenesis
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
Carcinogenesis
Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition.
Carcinogenesis
Isoform-specific expression of 14-3-3 proteins in human astrocytoma.
Carcinogenesis
Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues.
Carcinogenesis
Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation.
Carcinogenesis
KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Carcinogenesis
Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis.
Carcinogenesis
Knockdown of A-kinase anchor protein 4 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/?-catenin pathway in human gastric cancer cells.
Carcinogenesis
Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
Carcinogenesis
Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells.
Carcinogenesis
Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model.
Carcinogenesis
Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38.
Carcinogenesis
LC-0882 targets PAK4 and inhibits PAK4-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells.
Carcinogenesis
Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.
Carcinogenesis
LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.
Carcinogenesis
LINC00339 regulates ROCK1 by miR-152 to promote cell proliferation and migration in hepatocellular carcinoma.
Carcinogenesis
LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation.
Carcinogenesis
Litopenaeus vannamei CK2 is involved in shrimp innate immunity by modulating hemocytes apoptosis.
Carcinogenesis
LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer.
Carcinogenesis
LKB1 loss of function studied in vivo.
Carcinogenesis
Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
Carcinogenesis
Long non-coding RNA SNHG5 sponges miR-26a to promote the tumorigenesis of osteosarcoma by targeting ROCK1.
Carcinogenesis
Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers.
Carcinogenesis
Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Carcinogenesis
Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.
Carcinogenesis
LRRK2 is a candidate prognostic biomarker for clear cell renal cell carcinoma.
Carcinogenesis
Lysophosphatidic acid-RAGE axis promotes lung and mammary oncogenesis via protein kinase B and regulating tumor microenvironment.
Carcinogenesis
Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.
Carcinogenesis
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer.
Carcinogenesis
Mechanistic insights into the urea-induced denaturation of kinase domain of human integrin linked kinase.
Carcinogenesis
Melanotic Schwannoma of the Vulva: A Case Report and Review of the Literature.
Carcinogenesis
Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer.
Carcinogenesis
MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase.
Carcinogenesis
MicroRNA-140-5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21-activated kinase 4.
Carcinogenesis
MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.
Carcinogenesis
MicroRNA-26b-5p enhances T cell responses by targeting PIM-2 in hepatocellular carcinoma.
Carcinogenesis
MicroRNA?16?5p regulates cell survival, cell cycle and apoptosis by targeting AKT3 in prostate cancer cells.
Carcinogenesis
MiRNA-206 suppresses PGE2-induced colorectal cancer cell proliferation, migration, and invasion by targetting TM4SF1.
Carcinogenesis
Mixed lineage kinase-4 promotes gastric carcinoma tumorigenesis through suppression of the c-Jun N-terminal kinase signaling pathway.
Carcinogenesis
MK2 Regulates Ras Oncogenesis through Stimulating ROS Production.
Carcinogenesis
Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.
Carcinogenesis
Molecular alterations in non-small cell lung carcinomas of the young.
Carcinogenesis
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Carcinogenesis
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Carcinogenesis
Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family.
Carcinogenesis
Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma.
Carcinogenesis
Mutations in the p53 and SCID genes cooperate in tumorigenesis.
Carcinogenesis
Mutations of the STK11 gene in sporadic gastric carcinoma.
Carcinogenesis
Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel.
Carcinogenesis
MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.
Carcinogenesis
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
Carcinogenesis
Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer.
Carcinogenesis
Nek6 Mediates Human Cancer Cell Transformation and Is a Potential Cancer Therapeutic Target.
Carcinogenesis
Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.
Carcinogenesis
NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate.
Carcinogenesis
NOK/STYK1 promotes the genesis and remodeling of blood and lymphatic vessels during tumor progression.
Carcinogenesis
Notch signaling via regulation of RB and p-AKT but not PIK3CG contributes to MIA PaCa-2 cell growth and migration to affect pancreatic carcinogenesis.
Carcinogenesis
Novel PRKAR1A gene mutations in Carney Complex.
Carcinogenesis
NUCKS nuclear elevated expression indicates progression and prognosis of ovarian cancer.
Carcinogenesis
NUCKS1 overexpression is a novel biomarker for recurrence-free survival in cervical squamous cell carcinoma.
Carcinogenesis
Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-?-inducible protein 10 in a casein kinase 2-dependent manner.
Carcinogenesis
Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-?B-activating potential.
Carcinogenesis
Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta.
Carcinogenesis
Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.
Carcinogenesis
Overexpression and activation of Akt2 protein in oral squamous cell carcinoma.
Carcinogenesis
Overexpression of 14-3-3gamma causes polyploidization in H322 lung cancer cells.
Carcinogenesis
Overexpression of Pim-1 in bladder cancer.
Carcinogenesis
Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer.
Carcinogenesis
p21-activated kinase 4 regulation of endometrial cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion.
Carcinogenesis
p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2.
Carcinogenesis
Paired box gene 5 may modulate Proviral Integration of Moloney virus2gene and protein expression in mature B-cells.
Carcinogenesis
PAK1 tyrosine phosphorylation is required to induce epithelial-mesenchymal transition and radioresistance in lung cancer cells.
Carcinogenesis
Papillary thyroid carcinoma in a 9-year-old girl with ataxia-telangiectasia.
Carcinogenesis
Pathological classification and molecular genetics of meningiomas.
Carcinogenesis
Pathological neoangiogenesis depends on oxidative stress regulation by ATM.
Carcinogenesis
PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.
Carcinogenesis
PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation.
Carcinogenesis
PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound.
Carcinogenesis
Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors.
Carcinogenesis
Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC).
Carcinogenesis
PEUTZ-JEGHERS SYNDROME IN RESOURCE-LIMITED SCENARIO.
Carcinogenesis
Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes.
Carcinogenesis
Physiological functions of Pten in mouse tissues.
Carcinogenesis
Phytoconstituents and Medicinal Plants for Anticancer Drug Discovery: Computational Identification of Potent Inhibitors of PIM1 Kinase.
Carcinogenesis
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
Carcinogenesis
Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma.
Carcinogenesis
Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene.
Carcinogenesis
Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.
Carcinogenesis
Pim-2 Activates API-5 to Inhibit the Apoptosis of Hepatocellular Carcinoma Cells Through NF-kappaB Pathway.
Carcinogenesis
Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.
Carcinogenesis
PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.
Carcinogenesis
PKA RI?/A-kinase anchoring proteins 10 signaling pathway and the prognosis of colorectal cancer.
Carcinogenesis
PKN1 modulates TGF? and EGF signaling in HEC-1-A endometrial cancer cell line.
Carcinogenesis
Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population.
Carcinogenesis
Portrait of PTEN: messages from mutant mice.
Carcinogenesis
Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9, a zinc finger protein.
Carcinogenesis
Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.
Carcinogenesis
PPTR-1 counterAkts insulin signaling.
Carcinogenesis
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
Carcinogenesis
Prognostic implications of phosphatidylinositol 3-kinase/AKT signaling pathway activation in gastric carcinomas.
Carcinogenesis
Prognostic role of TPL2 in early?stage non?small cell lung cancer.
Carcinogenesis
Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.
Carcinogenesis
Prognostic significance of activated AKT expression in soft-tissue sarcoma.
Carcinogenesis
Prognostic significance of Aurora-A expression in human bladder cancer.
Carcinogenesis
Prognostic value of activated Akt expression in oral squamous cell carcinoma.
Carcinogenesis
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinogenesis
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Carcinogenesis
Protein kinase B alpha/Akt1 regulates placental development and fetal growth.
Carcinogenesis
Protein kinase CK2 in mammary gland tumorigenesis.
Carcinogenesis
Protein kinase CK2: signaling and tumorigenesis in the mammary gland.
Carcinogenesis
Protein kinase CK2? catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
Carcinogenesis
Protein kinase D and keratinocyte proliferation.
Carcinogenesis
Protein kinase D1 attenuates tumorigenesis in colon cancer by modulating ?-catenin/T cell factor activity.
Carcinogenesis
Protein kinase d1 has a key role in wound healing and skin carcinogenesis.
Carcinogenesis
Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway.
Carcinogenesis
Protein kinase D2 promotes the proliferation of glioma cells by regulating Golgi phosphoprotein 3.
Carcinogenesis
Proteomic differential display analysis shows up-regulation of 14-3-3 sigma protein in human scirrhous-type gastric carcinoma cells.
Carcinogenesis
Quantitative Analysis of Ubiquitinated Proteins in Human Pituitary and Pituitary Adenoma Tissues.
Carcinogenesis
RACK1 affects the progress of G2/M by regulating Aurora-A.
Carcinogenesis
Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer.
Carcinogenesis
Raf-1 addiction in Ras-induced skin carcinogenesis.
Carcinogenesis
Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49.
Carcinogenesis
Rat mammary carcinogenesis induced by in situ expression of constitutive Raf kinase activity is prevented by tethering Raf to the plasma membrane.
Carcinogenesis
Receptor for activated C kinase 1 (RACK1) promotes the progression of OSCC via the AKT/mTOR pathway.
Carcinogenesis
Reduction of 14-3-3 proteins correlates with increased sensitivity to killing of human lung cancer cells by ionizing radiation.
Carcinogenesis
Regorafenib sensitizes human breast cancer cells to radiation by inhibiting multiple kinases and inducing DNA damage.
Carcinogenesis
Regulation of angiogenesis by glycogen synthase kinase-3beta.
Carcinogenesis
Regulation of Drosophila tracheal system development by protein kinase B.
Carcinogenesis
Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
Carcinogenesis
Regulation of glycogen synthase kinase 3beta functions by modification of the small ubiquitin-like modifier.
Carcinogenesis
Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases.
Carcinogenesis
Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins.
Carcinogenesis
Regulation of tumorigenic splicing by protein condensates with specific biophysical properties.
Carcinogenesis
Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.
Carcinogenesis
Resistance to anoikis in transcoelomic shedding: the role of glycolytic enzymes.
Carcinogenesis
Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.
Carcinogenesis
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Carcinogenesis
RhoB facilitates c-Myc turnover by supporting efficient nuclear accumulation of GSK-3.
Carcinogenesis
RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer.
Carcinogenesis
RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
Carcinogenesis
RO3280, A Novel PLK1 Inhibitor, Suppressed Proliferation of MCF-7 Breast Cancer Cells Through Induction of Cell Cycle Arrest at G2/M Point.
Carcinogenesis
ROCK1 and ROCK2 are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion.
Carcinogenesis
Rock2 promotes the invasion and metastasis of hepatocellular carcinoma by modifying MMP2 ubiquitination and degradation.
Carcinogenesis
Role of glycogen synthase kinase-3? inhibitor AZD1080 in ovarian cancer.
Carcinogenesis
Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.
Carcinogenesis
Role of Raf-kinase inhibitor protein in colorectal cancer and its regulation by hydroxycamptothecine.
Carcinogenesis
Role of serine/threonine kinase 33 methylation in colorectal cancer and its clinical significance.
Carcinogenesis
Role of the oncogenic Raf-1 in orchestration of discrete nuclear factor-kappaB-activating pathways.
Carcinogenesis
Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells.
Carcinogenesis
SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest.
Carcinogenesis
Selective and transient activation of protein kinase C alpha by fumonisin B1, a ceramide synthase inhibitor mycotoxin, in cultured porcine renal cells.
Carcinogenesis
Serine/Threonine Kinase Pim-2 Promotes Liver Tumorigenesis Induction Through Mediating Survival and Preventing Apoptosis of Liver Cell.
Carcinogenesis
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
Carcinogenesis
ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer.
Carcinogenesis
Significance of nuclear p-Akt in endometrial carcinogenesis: rapid translocation of p-Akt Into the nucleus by estrogen, possibly resulting in inhibition of apoptosis.
Carcinogenesis
Silencing Aurora-A with siRNA inhibits cell proliferation in human lung adenocarcinoma cells.
Carcinogenesis
Silencing of casein kinase 2 inhibits PKC?induced cell invasion by targeting MMP?9 in MCF?7 cells.
Carcinogenesis
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.
Carcinogenesis
SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling.
Carcinogenesis
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.
Carcinogenesis
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.
Carcinogenesis
Specific inhibition of the Akt1 pleckstrin homology domain by D-3-deoxy-phosphatidyl-myo-inositol analogues.
Carcinogenesis
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.
Carcinogenesis
Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis.
Carcinogenesis
Stable knockdown of protein kinase CK2-alpha (CK2?) inhibits migration and invasion and induces inactivation of hedgehog signaling pathway in hepatocellular carcinoma Hep G2 cells.
Carcinogenesis
STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis.
Carcinogenesis
STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Carcinogenesis
STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma.
Carcinogenesis
STRAD pseudokinases regulate axogenesis and LKB1 stability.
Carcinogenesis
Structural bases of protein kinase CK2 inhibition.
Carcinogenesis
Structural insights into mis-regulation of protein kinase A in human tumors.
Carcinogenesis
Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR.
Carcinogenesis
Structure of a Moloney murine leukemia virus-virus-like 30 recombinant: implications for transduction of the c-Ha-ras proto-oncogene.
Carcinogenesis
Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains.
Carcinogenesis
STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling.
Carcinogenesis
Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori.
Carcinogenesis
Suppression of multiple processes relevant to cancer progression by benzyl isothiocyanate may result from the inhibition of Aurora A kinase activity.
Carcinogenesis
Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032.
Carcinogenesis
Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101.
Carcinogenesis
T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23).
Carcinogenesis
TACC1-chTOG-Aurora A protein complex in breast cancer.
Carcinogenesis
Targeted proteomic analysis of 14-3-3 sigma in nasopharyngeal carcinoma.
Carcinogenesis
Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials.
Carcinogenesis
Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.
Carcinogenesis
Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.
Carcinogenesis
Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders.
Carcinogenesis
Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells.
Carcinogenesis
TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases.
Carcinogenesis
The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development.
Carcinogenesis
The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines.
Carcinogenesis
The Apoptosis Regulator 14-3-3? and Its Potential as a Therapeutic Target in Pituitary Oncocytoma.
Carcinogenesis
The expression of seven 14-3-3 isoforms in human meningioma.
Carcinogenesis
The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network.
Carcinogenesis
The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.
Carcinogenesis
The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C.
Carcinogenesis
The induction of endoreduplication and polyploidy by elevated expression of 14-3-3?.
Carcinogenesis
The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.
Carcinogenesis
The nuclear receptor peroxisome proliferator-activated receptor-?/? (PPAR?/?) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress.
Carcinogenesis
The over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.
Carcinogenesis
The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression.
Carcinogenesis
The PPLA motif of glycogen synthase kinase 3beta is required for interaction with Fe65.
Carcinogenesis
The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors.
Carcinogenesis
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Carcinogenesis
The role of protein kinase CK2 in glioblastoma development.
Carcinogenesis
The role of the c-Jun N-terminal kinase 2-?-isoform in non-small cell lung carcinoma tumorigenesis.
Carcinogenesis
The scaffold protein IB1/JIP-1 controls the activation of JNK in rat stressed urothelium.
Carcinogenesis
The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-? precursor protein-dependent mechanism.
Carcinogenesis
The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway.
Carcinogenesis
The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer.
Carcinogenesis
The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.
Carcinogenesis
Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes.
Carcinogenesis
Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.
Carcinogenesis
Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2.
Carcinogenesis
Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis.
Carcinogenesis
Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissues.
Carcinogenesis
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy.
Carcinogenesis
Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions.
Carcinogenesis
Tug of War between Survival and Death: Exploring ATM Function in Cancer.
Carcinogenesis
TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma.
Carcinogenesis
Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching.
Carcinogenesis
UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism.
Carcinogenesis
Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma.
Carcinogenesis
Updates on HIPK2: a resourceful oncosuppressor for clearing cancer.
Carcinogenesis
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident.
Carcinogenesis
Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B.
Carcinogenesis
Various AKIP1 expression levels affect its subcellular localization but have no effect on NF-kappaB activation.
Carcinogenesis
Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinogenesis
WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.
Carcinogenesis
Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis.
Carcinogenesis
Wnt/?-catenin activation and macrophage induction during liver cancer development following steatosis.
Carcinogenesis
[Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]
Carcinogenesis
[Change in the protein kinase activity of glandular stomach mucosa in rats during malignant transformation]
Carcinogenesis
[Clinicopathological significance of expressions of DNA dependent protein kinase catalytic subunit and P16 in colorectal carcinoma]
Carcinogenesis
[Correlation of HIPK2 expression with HPV infection and apoptosis in cervical cancer]
Carcinogenesis
[Effect of Aurora A on biological phenotypes of prostate cancer cells]
Carcinogenesis
[Effect of aurora A on carcinogenesis of human prostate cancer]
Carcinogenesis
[Effect of Bmi-1 Silencing on the Proliferation of K562/ADM Cells in vitro and in vivo].
Carcinogenesis
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Carcinogenesis
[Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma].
Carcinogenesis
[Poly(ADP-ribosa)polymerase--the relationships with life span and carcinogenesis]
Carcinogenesis
[Recent progress in the biology of small cell bronchial carcinoma]
Carcinogenesis
[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms]
Carcinogenesis
[The function of Aurora A and its role in the development of liver cancer].
Carcinogenesis
[The over-expression of serine/threonine kinase 15 protein in oral carcinogenesis]
Carcinogenesis
[The underlying mechanisms of overcoming EGFR-TKIs resistance by casein kinase 2 inhibitor].
Carcinoid Tumor
Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation.
Carcinoid Tumor
Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors.
Carcinoid Tumor
Expression of p-AKT and p-mTOR in a large series of bronchopulmonary neuroendocrine tumors.
Carcinoid Tumor
Focal Adhesion Kinase, a Downstream Mediator of Raf-1 Signaling, Suppresses Cellular Adhesion, Migration, and Neuroendocrine Markers in BON Carcinoid Cells.
Carcinoid Tumor
Growth factor receptor expression in human gastroenteropancreatic neuroendocrine tumours.
Carcinoid Tumor
Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth.
Carcinoid Tumor
Lithium inhibits carcinoid cell growth in vitro.
Carcinoid Tumor
MG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine Phenotype.
Carcinoid Tumor
Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion.
Carcinoid Tumor
Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells.
Carcinoid Tumor
Synergistic Effect of Pasireotide and Teriflunomide in Carcinoids in vitro.
Carcinoid Tumor
Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway.
Carcinoid Tumor
ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells.
Carcinoma
(-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor.
Carcinoma
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Carcinoma
14-3-3 protein beta/alpha as a urinary biomarker for renal cell carcinoma: proteomic analysis of cyst fluid.
Carcinoma
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
Carcinoma
14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.
Carcinoma
14-3-3? silencing retards tongue squamous cell carcinoma progression by inhibiting cell survival and migration.
Carcinoma
7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ER?, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway.
Carcinoma
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Carcinoma
A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.
Carcinoma
A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma.
Carcinoma
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.
Carcinoma
A novel p70 S6 kinase-microRNA biogenesis axis mediates multicellular spheroid formation in ovarian cancer progression.
Carcinoma
A p38?-Selective Chemosensor for use in Unfractionated Cell Lysates.
Carcinoma
A-kinase interacting protein 1 high expression correlates with advanced tumor stage and poor overall survival in surgical patients with clear cell renal cell carcinoma.
Carcinoma
Aberrant methylation of the death-associated protein kinase 1 (DAPK1) CpG island in chronic myeloid leukemia.
Carcinoma
Abnormal DNA-PKcs and Ku 70/80 expression may promote malignant pathological processes in gastric carcinoma.
Carcinoma
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Carcinoma
Activation of AKT in feline mammary carcinoma: A new prognostic factor for feline mammary tumours.
Carcinoma
Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxin.
Carcinoma
Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells.
Carcinoma
Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine.
Carcinoma
Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells.
Carcinoma
Activation of signal transduction kinases by tamoxifen.
Carcinoma
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
Carcinoma
Activation of the protein kinase a signal transduction pathway by granulocyte-macrophage colony-stimulating factor or by genetic manipulation reduces cytoskeletal organization in Lewis lung carcinoma variants.
Carcinoma
Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia.
Carcinoma
Adenylate cyclase and protein phosphokinase activities in human thyroid. Comparison of normal glands, hyperfunctional nodules and carcinomas.
Carcinoma
Akt activation correlates with the tumor aggressiveness in Tunisian patients with bladder cancer.
Carcinoma
Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma.
Carcinoma
Alleviating the suppression of glycogen synthase kinase-3beta by Akt leads to the phosphorylation of cAMP-response element-binding protein and its transactivation in intact cell nuclei.
Carcinoma
Aloe-emodin, an anthraquinone, in vitro inhibits proliferation and induces apoptosis in human colon carcinoma cells.
Carcinoma
Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer.
Carcinoma
Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.
Carcinoma
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas.
Carcinoma
An automated image capture and quantitation approach to identify proteins affecting tumor cell proliferation.
Carcinoma
Analysis of Cell-type Specific Expression of CK1{varepsilon} in Various Tissues of Young Adult BALB/c Mice and in Mammary Tumors of SV40 T-Ag Transgenic Mice.
Carcinoma
Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma.
Carcinoma
Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29.
Carcinoma
Antisense oligonucleotides against protein kinase CK2-alpha inhibit growth of squamous cell carcinoma of the head and neck in vitro.
Carcinoma
Antisense raf oligodeoxyribonucleotide is a radiosensitizer in vivo.
Carcinoma
Antitumor effect and potentiation or reduction in cytotoxic drug activity in human colon carcinoma cells by the Raf kinase inhibitor (RKI) BAY 43-9006.
Carcinoma
Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.
Carcinoma
Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro study.
Carcinoma
Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses.
Carcinoma
Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and p21-activated kinase 2.
Carcinoma
ASK1 mediates apoptotic cell death induced by genotoxic stress.
Carcinoma
Association of elevated protein kinase CK2 activity with aggressive behavior of squamous cell carcinoma of the head and neck.
Carcinoma
Associations of ATM Polymorphisms With Survival in Advanced Esophageal Squamous Cell Carcinoma Patients Receiving Radiation Therapy.
Carcinoma
Asymmetric expression of protein kinase CK2 subunits in human kidney tumors.
Carcinoma
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Carcinoma
ATGL promotes the proliferation of hepatocellular carcinoma cells via the p-AKT signaling pathway.
Carcinoma
Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers.
Carcinoma
Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells.
Carcinoma
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis.
Carcinoma
Aurora B expression in metastatic effusions from advanced-stage ovarian serous carcinoma is predictive of intrinsic chemotherapy resistance.
Carcinoma
Aurora kinases as prognostic biomarkers in ovarian carcinoma.
Carcinoma
Author Correction: Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma
B-raf exon 15 mutations are common in primary melanoma resection specimens but not associated with clinical outcome.
Carcinoma
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Carcinoma
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
Carcinoma
BDNF/TrkB/Akt Signaling Pathway Epithelial Odontogenic Tumors and Keratocyst: An Immunohistochemical Study Comparative With Dental Germs.
Carcinoma
beta-Catenin alteration in cancer of the ampulla of Vater.
Carcinoma
Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.
Carcinoma
Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis.
Carcinoma
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets.
Carcinoma
c-erbB-2 oncoprotein expression related to chemoradioresistance in esophageal squamous cell carcinoma.
Carcinoma
c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines.
Carcinoma
Calcium-activated, phospholipid-dependent protein kinase in human gastric mucosa and carcinoma.
Carcinoma
Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation.
Carcinoma
Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines.
Carcinoma
Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines.
Carcinoma
Casein kinase II alpha subunit and C1-inhibitor are independent predictors of outcome in patients with squamous cell carcinoma of the lung.
Carcinoma
Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1).
Carcinoma
Caveolin-1 and 14-3-3 sigma expression in follicular variant of thyroid papillary carcinoma.
Carcinoma
Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma.
Carcinoma
Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis.
Carcinoma
Cell signaling pathways associated with a reduction in mammary cancer burden by dietary common bean (Phaseolus vulgaris L.).
Carcinoma
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Carcinoma
Characterization of casein kinase II in human colonic carcinomas after heterotransplantation into nude mice.
Carcinoma
Checkpoint kinase 1 inhibitors as targeted molecular agents for clear cell carcinoma of the ovary.
Carcinoma
Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding.
Carcinoma
Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c?Raf/MEK/ERK signaling pathway.
Carcinoma
Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma.
Carcinoma
Clinical and biological significance of GSK-3beta inactivation in breast cancer-an immunohistochemical study.
Carcinoma
Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma.
Carcinoma
Clinical implications of BRAF mutation in thyroid carcinoma.
Carcinoma
Clinical significance of 14-3-3 zeta in human esophageal cancer.
Carcinoma
Clinical significance of raf-1 kinase inhibitor protein in oral squamous cell carcinoma and its role in cell metastasis.
Carcinoma
Clinicopathological and biological analysis of PIK3CA mutation and amplification in cervical carcinomas.
Carcinoma
Clinicopathological features and prognostic implications of Raf kinase inhibitor protein downregulation in tongue squamous cell carcinoma.
Carcinoma
Clinicopathological significance of ribosomal protein S6 kinase A6 in lung squamous cell carcinoma: an immunohistochemical and RNA-seq study.
Carcinoma
Close localization of DAP-kinase positive tumour-associated macrophages and apoptotic colorectal cancer cells.
Carcinoma
Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma.
Carcinoma
Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma.
Carcinoma
Comparative analysis of a panel of biomarkers related to protein phosphatase 2A between laryngeal squamous cell carcinoma tissues and adjacent normal tissues.
Carcinoma
Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.
Carcinoma
Constitutive activation of glycogen synthase kinase-3beta correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer.
Carcinoma
Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression.
Carcinoma
Copy-number increase of AURKA in gastric cancers in a Chinese population: a correlation with tumor progression.
Carcinoma
Correlation between STK33 and the pathology and prognosis of lung cancer.
Carcinoma
CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy.
Carcinoma
Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells.
Carcinoma
Cross-signaling among phosphinositide-3 kinase, mitogen-activated protein kinase and sonic hedgehog pathways exists in esophageal cancer.
Carcinoma
CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer.
Carcinoma
Cyclooxygenase 2 in gastric carcinoma is expressed in doublecortin- and CaM kinase-like-1-positive tuft cells.
Carcinoma
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene.
Carcinoma
DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer.
Carcinoma
Decreased expression and aberrant methylation of Raf kinase inhibitory protein gene in esophageal squamous cell carcinoma.
Carcinoma
Decreased expression of 14-3-3 ?, an early event of malignant transformation of respiratory epithelium, also facilitates progression of squamous cell lung cancer.
Carcinoma
Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas.
Carcinoma
Development of an Immunohistochemical Assay to Detect the Ataxia-Telangiectasia Mutated (ATM) Protein in Gastric Carcinoma.
Carcinoma
Different cellular localization, translocation, and insulin-induced phosphorylation of PKBalpha in HepG2 cells and hepatocytes.
Carcinoma
Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma.
Carcinoma
Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.
Carcinoma
Differential expression of ras signal transduction mediators in verrucous and squamous cell carcinomas of the upper aerodigestive tract.
Carcinoma
Differential expression of the subunits of the glucose-6-phosphatase system in the clear cell type of human renal cell carcinoma - no evidence for an overexpression of protein kinase B.
Carcinoma
Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma.
Carcinoma
Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.
Carcinoma
Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features.
Carcinoma
Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.
Carcinoma
DNA Damage Repair and Telomere Length in Normal Breast, Preneoplastic Lesions, and Invasive Cancer.
Carcinoma
DNA-dependent protein kinase catalytic subunit functions in metastasis and influences survival in advanced-stage laryngeal squamous cell carcinoma.
Carcinoma
DNA-dependent protein kinase: effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines.
Carcinoma
DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues.
Carcinoma
DNA-PKcs and Ku70 are predictive markers for poor prognosis of patients with gall bladder malignancies.
Carcinoma
DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery.
Carcinoma
DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-?1/Smad Signaling Pathway.
Carcinoma
Down-regulation of the tumor suppressor protein 14-3-3sigma is a sporadic event in cancer of the breast.
Carcinoma
Downregulation of 14-3-3? inhibits proliferation and migration in osteosarcoma cells.
Carcinoma
Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway.
Carcinoma
Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival.
Carcinoma
Dual inhibition of DNA-PKcs and mTOR by CC-115 potently inhibits human renal cell carcinoma cell growth.
Carcinoma
Dual inhibition of EGFR and mTOR pathways in small cell lung cancer.
Carcinoma
Editorial comment on: Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinoma
Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma.
Carcinoma
Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas.
Carcinoma
Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.
Carcinoma
Effects of siRNA specific to the protein kinase CK2? on apoptosis of laryngeal carcinoma cells.
Carcinoma
EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: Role of c-Jun N-terminal kinase.
Carcinoma
EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma.
Carcinoma
Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.
Carcinoma
Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells.
Carcinoma
Epigenetic inactivation of 14-3-3 sigma in oral carcinoma: association with p16(INK4a) silencing and human papillomavirus negativity.
Carcinoma
ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway.
Carcinoma
Evaluation of Prexasertib, a Checkpoint Kinase 1 Inhibitor, in a Phase Ib Study of Patients with Squamous Cell Carcinoma.
Carcinoma
Evaluation of protein kinase CK2 as a therapeutic target for squamous cell carcinoma of cats.
Carcinoma
Evaluation of the p-AKT, p-JNK and FoxO3a function in oral epithelial dysplasia.
Carcinoma
EWS-Fli1 up-regulates expression of the Aurora A and Aurora B kinases.
Carcinoma
Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma.
Carcinoma
Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression.
Carcinoma
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
Carcinoma
Expression and prognostic significance of pyruvate dehydrogenase kinase 1 in bladder urothelial carcinoma.
Carcinoma
Expression and prognostic significance of the P53-related DNA damage repair proteins checkpoint kinase 1 (CHK1) and growth arrest and DNA-damage-inducible 45 alpha (GADD45A) in human oral squamous cell carcinoma.
Carcinoma
Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma.
Carcinoma
Expression and Significance of RKIP and E-cadherin in Lung Squamous Cell Carcinoma.
Carcinoma
Expression of 14-3-3 sigma and eta proteins is unrelated to survival in metastatic high-grade serous carcinoma.
Carcinoma
Expression of Abl interactor 1 and its prognostic significance in breast cancer: a tissue-array-based investigation.
Carcinoma
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Carcinoma
Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma.
Carcinoma
Expression of Concern: Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration and invasion in human hepatoma carcinoma by upregulating ROCK1.
Carcinoma
Expression of cyclin D1 and GSK-3beta and their predictive value of prognosis in squamous cell carcinomas of the tongue.
Carcinoma
Expression of DNA-dependent protein kinase catalytic subunit in laryngeal squamous cell carcinoma and its importance.
Carcinoma
Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
Carcinoma
Expression of HSP70 and JNK-related proteins in human liver cancer: Potential effects on clinical outcome.
Carcinoma
Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma.
Carcinoma
Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses.
Carcinoma
Expression of p-Akt in ovarian serous carcinoma and its association with proliferation and apoptosis.
Carcinoma
Expression of P-Akt, NFkappaB and their correlation with human papillomavirus infection in cervical carcinoma.
Carcinoma
Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis.
Carcinoma
Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
Carcinoma
Expression of phosphorylated Akt in patients with small cell carcinoma of the lung indicates good prognosis.
Carcinoma
Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma.
Carcinoma
Expression of protein tyrosine kinases in head and neck squamous cell carcinomas.
Carcinoma
Expression of Raf-1 kinase inhibitory protein in carcinoma of the ampulla of Vater.
Carcinoma
Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition.
Carcinoma
Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.
Carcinoma
Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance.
Carcinoma
Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.
Carcinoma
Fibrolamellar Carcinoma: A Concise Review.
Carcinoma
Fibrolamellar carcinoma: A histologically unique tumor with unique molecular findings.
Carcinoma
Fibrolamellar Carcinoma: What Is New and Why It Matters.
Carcinoma
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity.
Carcinoma
Frequent beta-catenin alteration in gallbladder carcinomas.
Carcinoma
Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma.
Carcinoma
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma.
Carcinoma
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Carcinoma
Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation.
Carcinoma
Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition.
Carcinoma
Further studies on the quaternary structure of yeast casein kinase II.
Carcinoma
G Protein Alpha S Subunit Promotes Cell Proliferation of Renal Cell Carcinoma with Involvement of Protein Kinase A Signaling.
Carcinoma
Gene sequencing and expression of Raf-1 in lymphatic metastasis of hypopharyngeal carcinoma.
Carcinoma
Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.
Carcinoma
Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.
Carcinoma
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion.
Carcinoma
Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.
Carcinoma
Glycogen synthase kinase-3 beta (GSK3?)-mediated phosphorylation of ETS1 promotes progression of ovarian carcinoma.
Carcinoma
Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma.
Carcinoma
Granulocyte-macrophage colony-stimulating factor stimulates the metastatic properties of Lewis lung carcinoma cells through a protein kinase A signal-transduction pathway.
Carcinoma
GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.
Carcinoma
GSK-3 inhibition in vitro and in vivo enhances antitumor effect of sorafenib in renal cell carcinoma (RCC).
Carcinoma
GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma.
Carcinoma
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
Carcinoma
HER-2/AKT expression in upper urinary tract urothelial carcinoma: prognostic implications.
Carcinoma
High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder.
Carcinoma
HIPK2 inhibits cell metastasis and improves chemosensitivity in esophageal squamous cell carcinoma.
Carcinoma
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma.
Carcinoma
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Carcinoma
Histamine inhibits the production of interferon-induced protein of 10 kDa in human squamous cell carcinoma and melanoma.
Carcinoma
Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.
Carcinoma
Hypermethylation-mediated partial transcriptional silencing of DAP-kinase gene in bladder cancer.
Carcinoma
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis.
Carcinoma
Identification of HRAS as cancer-promoting gene in gastric carcinoma cell aggressiveness.
Carcinoma
Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes.
Carcinoma
ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway.
Carcinoma
Immunohistochemical and genetic characteristics of HPV-associated endocervical carcinoma with an invasive stratified mucin-producing carcinoma (ISMC) component.
Carcinoma
Immunohistochemical evaluation of ROCK activation in invasive breast cancer.
Carcinoma
Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis.
Carcinoma
Immunohistochemical expression of PDGFR, VEGF-C, and proteins of the mToR pathway before and after androgen deprivation therapy in prostate carcinoma: significant decrease after treatment.
Carcinoma
Immunologically defined subclasses of the protein kinase CK2 beta-subunit in prostate carcinoma cell lines.
Carcinoma
Immunoprofile of c-MET/PI3K signaling in human salivary gland tumors.
Carcinoma
In Silico-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma.
Carcinoma
Inactivation of homeodomain-interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53-dependent E-cadherin expression.
Carcinoma
Increased Activated Akt Expression in Renal Cell Carcinomas and Prognosis.
Carcinoma
Incremental Expression of 14-3-3 Protein Beta/Alpha in Urine Correlates with Advanced Stage and Poor Survival in Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma
Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells.
Carcinoma
Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway.
Carcinoma
Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".
Carcinoma
Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells.
Carcinoma
Inhibition of Ataxia-Telangiectasia Mutated by Antisense Oligonucleotide Nanoparticles Induces Radiosensitization of Head and Neck Squamous-Cell Carcinoma in Mice.
Carcinoma
Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells.
Carcinoma
Inhibition of glycogen synthase kinase 3 beta (GSK3?) suppresses the progression of esophageal squamous cell carcinoma by modifying STAT3 activity.
Carcinoma
Inhibition of glycolysis enhances cisplatin-induced apoptosis in ovarian cancer cells.
Carcinoma
Inhibition of p21-activated kinase 4 expression suppresses the proliferation of Hep-2 laryngeal carcinoma cells via activation of the ATM/Chk1/2/p53 pathway.
Carcinoma
Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells.
Carcinoma
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Carcinoma
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.
Carcinoma
Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stability.
Carcinoma
Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma.
Carcinoma
Interferon-gamma induced cell death: Regulation and contributions of nitric oxide, cJun N-terminal kinase, reactive oxygen species and peroxynitrite.
Carcinoma
Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells.
Carcinoma
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
Carcinoma
Involvement of the Wnt-?-catenin pathway in invasion and migration of oral squamous carcinoma cells.
Carcinoma
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells.
Carcinoma
Irciniastatin A induces potent and sustained activation of extracellular signal-regulated kinase and thereby promotes ectodomain shedding of tumor necrosis factor receptor 1 in human lung carcinoma A549 cells.
Carcinoma
Jatrorrhizine inhibits mammary carcinoma cells by targeting TNIK mediated Wnt/?-catenin signalling and epithelial-mesenchymal transition (EMT).
Carcinoma
K-ras p21 expression and activity in lung and lung tumors.
Carcinoma
Keratin 17 is co-expressed with 14-3-3 sigma in oral carcinoma in situ and squamous cell carcinoma and modulates cell proliferation and size but not cell migration.
Carcinoma
KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
Carcinoma
Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
Carcinoma
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Carcinoma
Landscape of genomic alterations in cervical carcinomas.
Carcinoma
Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells.
Carcinoma
Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma.
Carcinoma
LncRNA EGFR-AS1 Upregulates ROCK1 by Sponging miR-145 to Promote Esophageal Squamous Cell Carcinoma Cell Invasion and Migration.
Carcinoma
lncRNA HAND2-AS1 inhibits cancer cell proliferation, migration and invasion by downregulating ROCK1 in HPV-positive and negative cervical squamous cell carcinoma.
Carcinoma
Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration and invasion in human hepatoma carcinoma by upregulating ROCK1.
Carcinoma
Long noncoding RNA MORT overexpression inhibits cancer cell proliferation in oral squamous cell carcinoma by downregulating ROCK1.
Carcinoma
Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho-associated protein kinase 1.
Carcinoma
Loss of 14-3-3 sigma protein expression and presence of human papillomavirus type 16 E6 in oral squamous cell carcinoma.
Carcinoma
Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma.
Carcinoma
LRRK2 is a candidate prognostic biomarker for clear cell renal cell carcinoma.
Carcinoma
LY294002 enhances inhibitory effect of gemcitabine on proliferation of human pancreatic carcinoma PANC-1 cells.
Carcinoma
MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.
Carcinoma
MCP-1 stimulates spinal microglia via PI3K/Akt pathway in bone cancer pain.
Carcinoma
MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer.
Carcinoma
Melatonin Attenuates Her-2, p38 MAPK, p-AKT, and mTOR Levels in Ovarian Carcinoma of Ethanol-Preferring Rats.
Carcinoma
Metallothionein and p-Akt proteins in oral dysplasia and in oral squamous cell carcinoma: an immunohistochemical study.
Carcinoma
Metformin inhibits the migration and invasion of esophageal squamous cell carcinoma cells by downregulating the protein kinase B signaling pathway.
Carcinoma
Methylation and intratumoural heterogeneity of 14-3-3 sigma in oral cancer.
Carcinoma
Methylation of STK11 promoter is a risk factor for tumor stage and survival in clear cell renal cell carcinoma.
Carcinoma
MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma.
Carcinoma
MicroRNA-140-5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21-activated kinase 4.
Carcinoma
MicroRNA-148b inhibits proliferation and the epithelial-mesenchymal transition and increases radiosensitivity in non-small cell lung carcinomas by regulating ROCK1.
Carcinoma
MicroRNA?122 downregulates Rho?associated protein kinase 2 expression and inhibits the proliferation of prostate carcinoma cells.
Carcinoma
MicroRNA?195 inhibits cell proliferation, migration and invasion in laryngeal squamous cell carcinoma by targeting ROCK1.
Carcinoma
Mixed lineage kinase-4 promotes gastric carcinoma tumorigenesis through suppression of the c-Jun N-terminal kinase signaling pathway.
Carcinoma
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas.
Carcinoma
Molecular foundations for personalized therapy in prostate cancer.
Carcinoma
Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study.
Carcinoma
Mutational analysis of STK11 gene in ovarian carcinomas.
Carcinoma
Mutational analysis of the HIPK2 gene in keratoacanthoma and squamous cell carcinoma of the skin.
Carcinoma
Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
Carcinoma
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
Carcinoma
Mutations of the STK11 gene in sporadic gastric carcinoma.
Carcinoma
Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1.
Carcinoma
Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells.
Carcinoma
Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.
Carcinoma
Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells.
Carcinoma
Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma.
Carcinoma
Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2? expression and cell proliferation.
Carcinoma
Overexpression of glycogen synthase kinase-3 in ovarian carcinoma cells with acquired Paclitaxel resistance.
Carcinoma
Overexpression of Nuclear Protein Kinase CK2 beta Subunit and Prognosis in Human Gastric Carcinoma.
Carcinoma
Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis.
Carcinoma
Overexpression of platelet-derived growth factor-B increases the growth, invasion, and angiogenesis of gastric carcinoma cells through protein kinase B.
Carcinoma
Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis.
Carcinoma
Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.
Carcinoma
Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.
Carcinoma
Overexpression of the centrosomal protein Aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients.
Carcinoma
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Carcinoma
p-Akt and its relationship with clinicopathological features and survival in oral squamous cell carcinoma: an immunohistochemical study.
Carcinoma
p-AKT overexpression in primary renal cell carcinomas and their metastases.
Carcinoma
p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma.
Carcinoma
p21-activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1.
Carcinoma
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Carcinoma
Patterns and Significance of PIM Kinases in Urothelial Carcinoma.
Carcinoma
PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations.
Carcinoma
Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation.
Carcinoma
Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
Carcinoma
Phosphatidylinositol 3'-kinase, mTOR, and Glycogen synthase kinase-3 beta mediated regulation of p21 in human urothelial carcinoma cells.
Carcinoma
Phospho-?Np63?-dependent regulation of autophagic signaling through transcription and micro-RNA modulation.
Carcinoma
Phosphorylated p63 induces transcription of regulatory particle non ATP-ase subunit 13 and nitric oxide synthase-2 protein degradation.
Carcinoma
Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis.
Carcinoma
Phosphorylation of glycogen synthase kinase-3 beta at serine 9 confers cisplatin resistance in ovarian cancer cells.
Carcinoma
Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.
Carcinoma
PI3K/AKT pathway genetic alterations and dysregulation of expression in bladder cancer.
Carcinoma
PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma.
Carcinoma
Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity.
Carcinoma
Pleiotrophin exerts its migration and invasion effect through the neuropilin-1 pathway.
Carcinoma
PLK1 promotes epithelial-mesenchymal transition and metastasis of gastric carcinoma cells.
Carcinoma
Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases.
Carcinoma
Preponderance of the oncogenic V599E and V599K mutations in the B-raf kinase domain is enhanced in melanoma lymph node metastases.
Carcinoma
Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas.
Carcinoma
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Carcinoma
Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expression.
Carcinoma
Prognostic value of phospho-Akt in patients with non-small cell lung carcinoma: A meta-analysis.
Carcinoma
Prognostic Value of Raf Kinase Inhibitor Protein in Esophageal Squamous Cell Carcinoma.
Carcinoma
Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients.
Carcinoma
Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer.
Carcinoma
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinoma
Promoter methylation and expression of Raf kinase inhibitory protein in esophageal squamous cell carcinoma.
Carcinoma
Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas.
Carcinoma
Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin.
Carcinoma
Protein kinase A regulates Lewis lung carcinoma adherence to extracellular matrix components and spontaneous metastasis.
Carcinoma
Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells.
Carcinoma
Protein kinase B promotes radiation-induced regulatory T cell survival in bladder carcinoma.
Carcinoma
Protein kinase C and casein kinase II activities in two human colon carcinoma cell lines, HT-29 and CaCo-2: possible correlation with differentiation.
Carcinoma
Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cells.
Carcinoma
Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management
Carcinoma
Protein kinase D distribution in normal human epidermis, basal cell carcinoma and psoriasis.
Carcinoma
Protein kinase D1 induced epithelial-mesenchymal transition and invasion in salivary adenoid cystic carcinoma via E-cadherin/Snail regulation.
Carcinoma
Protein phosphatases limit tumor motility.
Carcinoma
Protein phosphatases-1 and -2A regulate tumor cell migration, invasion and cytoskeletal organization.
Carcinoma
Proteome analysis in the clinical chemistry laboratory: myth or reality?
Carcinoma
Proteomic differential display analysis shows up-regulation of 14-3-3 sigma protein in human scirrhous-type gastric carcinoma cells.
Carcinoma
Proteomic profiling of differential display analysis for human oral squamous cell carcinoma: 14-3-3 ? Protein is upregulated in human oral squamous cell carcinoma and dependent on the differentiation level.
Carcinoma
PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization.
Carcinoma
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
Carcinoma
Pyrvinium Sensitizes Clear Cell Renal Cell Carcinoma Response to Chemotherapy Via Casein Kinase 1?-Dependent Inhibition of Wnt/?-Catenin.
Carcinoma
Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells.
Carcinoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma
Raf kinase inhibitor protein expression correlates with differentiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma.
Carcinoma
Raf-1 and squamous cell carcinoma: Rok-ing the boat.
Carcinoma
Raf-1 kinase, epidermal growth factor receptors, and mutant Ras proteins in colonic carcinomas.
Carcinoma
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma
Rat mammary carcinogenesis induced by in situ expression of constitutive Raf kinase activity is prevented by tethering Raf to the plasma membrane.
Carcinoma
Recent advances in the research and development of RAF kinase inhibitors.
Carcinoma
Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma.
Carcinoma
Reduced expression of Raf-1 kinase inhibitory protein in renal cell carcinoma: a significant prognostic marker.
Carcinoma
Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
Carcinoma
Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma.
Carcinoma
Reduced LRP6 expression and increase in the interaction of GSK3? with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea.
Carcinoma
Regulation of casein kinase II activity by epidermal growth factor in human A-431 carcinoma cells.
Carcinoma
Regulation of Lewis lung carcinoma invasion and metastasis by protein kinase A.
Carcinoma
Regulation of protein kinase A activation and prostaglandin E2-stimulated migration of Lewis lung carcinoma clones.
Carcinoma
Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins.
Carcinoma
Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a?p-AKT-dependent manner.
Carcinoma
Reversal of P-glycoprotein-mediated multi-drug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocarcinoma cells.
Carcinoma
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma.
Carcinoma
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Thompson JM, Nguyen QH, Singh M, Pavesic MW, Nesterenko I, Nelson LJ, Liao AC, Razorenova OV.
Carcinoma
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
Carcinoma
RIalpha Influences Cellular Proliferation in Cancer Cells by Transporting RFC40 into the Nucleus.
Carcinoma
Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
Carcinoma
Ribosomal s6 protein kinase 4: a prognostic factor for renal cell carcinoma.
Carcinoma
RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma.
Carcinoma
RNA interference (RNAi) mediated stable knockdown of protein casein kinase 2-alpha (CK2?) inhibits migration and invasion and enhances cisplatin-induced apoptosis in HEp-2 laryngeal carcinoma cells.
Carcinoma
ROCK1 as a novel prognostic marker in vulvar cancer.
Carcinoma
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Carcinoma
RUNX3 reverses cisplatin resistance in esophageal squamous cell carcinoma via suppression of the protein kinase B pathway.
Carcinoma
Selective killing of p53-deficient cancer cells by SP600125.
Carcinoma
Selective reovirus killing of bladder cancer in a co-culture spheroid model.
Carcinoma
Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
Carcinoma
Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy.
Carcinoma
Silencing of long non-coding RNA CCAT2 depressed malignancy of oral squamous cell carcinoma via Wnt/?-catenin pathway.
Carcinoma
Silencing of the integrin-linked kinase gene induces the apoptosis in ovarian carcinoma.
Carcinoma
SMAD3 inducing the transcription of ?STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.
Carcinoma
SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia.
Carcinoma
Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.
Carcinoma
Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.
Carcinoma
Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer.
Carcinoma
Sorafenib stimulates human skin type mast cell degranulation and maturation.
Carcinoma
Sorafenib-associated remission of psoriasis in hypernephroma: case report.
Carcinoma
Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury.
Carcinoma
Stabilization of mismatch repair gene PMS2 by glycogen synthase kinase 3beta is implicated in the treatment of cervical carcinoma.
Carcinoma
Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit.
Carcinoma
STK11 Mutation Identified in Thyroid Carcinoma.
Carcinoma
STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.
Carcinoma
STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary-Mucinous Carcinoma of the Transverse Colon.
Carcinoma
STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis.
Carcinoma
STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Carcinoma
STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.
Carcinoma
STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-?1.
Carcinoma
Subcellular immunolocalization of protein kinase CK2 in normal and carcinoma cells.
Carcinoma
Suppression of migratory and metastatic pathways via blocking VEGFR1 and VEGFR2.
Carcinoma
Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.
Carcinoma
Synthesis and biological evaluation of nitroxide labeled pyrimidines as Aurora kinase inhibitors.
Carcinoma
Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.
Carcinoma
Synthetic bile acid derivatives induce apoptosis through a c-Jun N-terminal kinase and NF-kappaB-dependent process in human cervical carcinoma cells.
Carcinoma
Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma.
Carcinoma
T7 Peptide-Conjugated Lipid Nanoparticles for Dual Modulation of Bcl-2 and Akt-1 in Lung and Cervical Carcinomas.
Carcinoma
Targeting 14-3-3?-CDC25A interactions to trigger apoptotic cell death in skin cancer.
Carcinoma
The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas.
Carcinoma
The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.
Carcinoma
The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro.
Carcinoma
The enterocyte-like differentiation of the Caco-2 tumor cell line strongly correlates with responsiveness to cAMP and activation of kinase A pathway.
Carcinoma
The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor.
Carcinoma
The HNF-1?-USP28-Claspin pathway upregulates DNA damage-induced Chk1 activation in ovarian clear cell carcinoma.
Carcinoma
The in vitro effects of H-89, a specific inhibitor of protein kinase A, in the human colonic carcinoma cell line Caco-2.
Carcinoma
The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.
Carcinoma
The Investigational Aurora Kinase A Inhibitor MLN8237 Induces Defects in Cell Viability and Cell-Cycle Progression in Malignant Bladder Cancer Cells In Vitro and In Vivo.
Carcinoma
The Mammalian Target of Rapamycin-70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma.
Carcinoma
The novel cancer-testis antigen A-kinase anchor protein 4 (AKAP4) is a potential target for immunotherapy of ovarian serous carcinoma.
Carcinoma
The oncogenic B-raf V599E mutation occurs more frequently in melanomas at sun-protected body sites.
Carcinoma
The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation.
Carcinoma
The over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.
Carcinoma
The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation.
Carcinoma
The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors.
Carcinoma
The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
Carcinoma
The putative tumour suppressor microRNA-145, repressed by c-jun, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
Carcinoma
The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa.
Carcinoma
The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells.
Carcinoma
The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells.
Carcinoma
The role of Aurora A in hypoxia-inducible factor 1?-promoting malignant phenotypes of hepatocelluar carcinoma.
Carcinoma
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Carcinoma
The Role of Phenethyl Isothiocyanate on Bladder Cancer ADM Resistance Reversal and Its Molecular Mechanism.
Carcinoma
The role of the c-Jun N-terminal kinase 2-?-isoform in non-small cell lung carcinoma tumorigenesis.
Carcinoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Carcinoma
The Ste20 kinase MST4 plays a role in prostate cancer progression.
Carcinoma
The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.
Carcinoma
The two faces of a steroid antagonist: when an antagonist isn't.
Carcinoma
Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XIV. Mutational and non-mutational mechanisms as subsets of a more general mechanism. Part C. A defined cancer mutation.
Carcinoma
Therapeutic targeting of protein kinase CK2 gene expression in feline oral squamous cell carcinoma - a naturally occurring large animal model of head and neck cancer.
Carcinoma
Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma.
Carcinoma
TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma.
Carcinoma
Toxoplasma gondii: effect of infection on expression of 14-3-3 proteins in human epithelial cells.
Carcinoma
Tumor DNA-dependent protein kinase catalytic subunit expression is associated with hepatitis B surface antigen status and tumor progression in patients with hepatocellular carcinoma.
Carcinoma
Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer.
Carcinoma
Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.
Carcinoma
Tumor suppression by LKB1: SIK-ness prevents metastasis.
Carcinoma
Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway.
Carcinoma
TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma.
Carcinoma
Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes.
Carcinoma
Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma.
Carcinoma
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
Carcinoma
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident.
Carcinoma
Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618.
Carcinoma
Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.
Carcinoma
Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer.
Carcinoma
Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A.
Carcinoma
Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinoma
VX680/MK-0457, a potent and selective Aurora kinase inhibitor, targets both tumor and endothelial cells in clear cell renal cell carcinoma.
Carcinoma
Whole Exome Profiling of NSCLC Among African Americans.
Carcinoma
Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells.
Carcinoma
YWHAZ amplification/overexpression defines aggressive bladder cancer and contributes to chemo-/radio-resistance by suppressing caspase-mediated apoptosis.
Carcinoma
[Clinicopathological significance of expressions of DNA dependent protein kinase catalytic subunit and P16 in colorectal carcinoma]
Carcinoma
[Correlation between gene polymorphisms of Wnt signalling pathway related components and risk of gastric carcinoma: a case-control study]
Carcinoma
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines.]
Carcinoma
[Correlations between the p-Akt-mTOR-p70S6K pathway and clinicopathological features or chemoresistance of ovarian cancer].
Carcinoma
[Diagnostic value of protein markers in plasma exosomes of lung squamous cell carcinoma].
Carcinoma
[Effect of casein kinase 2? in esophageal carcinoma and its clinical significance].
Carcinoma
[Expression and clinical significance of epidermal growth factor receptor and protein kinase B in gastric carcinoma.]
Carcinoma
[Expression and clinical significance of phosphatidylinositol 3-kinase and protein kinase B in cervical carcinoma]
Carcinoma
[Expression and clinical significance of serine-threonine kinase/mammalian target of rapamycin/p70 S6K signal path- way in oral squamous cell carcinoma].
Carcinoma
[Expression and significance of p-AKT, p-GSK3? and ?-catenin in epithelial carcinoma of ovary].
Carcinoma
[Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation].
Carcinoma
[Expression of PKB protein in human squamous-cell carcinoma and adenocarcinoma of lung]
Carcinoma
[Expressions of SMG-1, ATM and P53 in laryngeal squamous cell carcinoma and their clinical significance].
Carcinoma
[Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC)-83 and SACC-LM cells]
Carcinoma
[Multiple forms of protein kinase from the cytoplasm of Ehrlich ascites carcinoma cells]
Carcinoma
[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]
Carcinoma
[Protein kinase D1 regulates the growth and metabolism of oral squamous carcinoma cells in tumor microenvironment].
Carcinoma
[Relationship between raf kinase inhibitor protein and metastasis of ovarian carcinoma]
Carcinoma
[Relationship between ROCK2 expression and clinicopathologic characteristics of esophageal squamous cell carcinoma].
Carcinoma
[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms]
Carcinoma
[Study of the expression of Aurora kinases in renal cell carcinoma].
Carcinoma
[The expression and activity of protein kinase A I in oral squamous cell carcinoma.]
Carcinoma
[The expression of PIK3CA in nasopharyngeal carcinoma].
Carcinoma
[The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma]
Carcinoma
[The relationship between PTEN expression and PI3K/AKT signal pathway in colon carcinoma]
Carcinoma
[The study of serine/threonine kinase signaling pathway-mediated inhibition of proliferation and invasion of oral squamous cell carcinoma transfected with p53 gene].
Carcinoma in Situ
Immunohistochemical evaluation of ROCK activation in invasive breast cancer.
Carcinoma in Situ
Keratin 17 is co-expressed with 14-3-3 sigma in oral carcinoma in situ and squamous cell carcinoma and modulates cell proliferation and size but not cell migration.
Carcinoma in Situ
Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
Carcinoma in Situ
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident.
Carcinoma, Adenoid Cystic
Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells.
Carcinoma, Adenoid Cystic
Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses.
Carcinoma, Adenoid Cystic
Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma.
Carcinoma, Adenoid Cystic
Protein kinase D1 induced epithelial-mesenchymal transition and invasion in salivary adenoid cystic carcinoma via E-cadherin/Snail regulation.
Carcinoma, Adenoid Cystic
Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma.
Carcinoma, Adenoid Cystic
[Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC)-83 and SACC-LM cells]
Carcinoma, Adenosquamous
Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.
Carcinoma, Basal Cell
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Carcinoma, Basal Cell
Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
Carcinoma, Basal Cell
Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin.
Carcinoma, Basal Cell
Protein kinase D distribution in normal human epidermis, basal cell carcinoma and psoriasis.
Carcinoma, Basal Cell
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Carcinoma, Basal Cell
Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.
Carcinoma, Basal Cell
Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes.
Carcinoma, Ductal
Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer.
Carcinoma, Ductal
Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis.
Carcinoma, Ductal
Double Heterozygosity of BRCA2 and STK11 in Familial Breast Cancer Detected by Exome Sequencing.
Carcinoma, Ductal
Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells.
Carcinoma, Ductal
Elevated Expression of IRS-1 Associates with p-Akt Expression and Predicts Poor Prognosis of Breast Invasive Ductal Carcinoma.
Carcinoma, Ductal
Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast.
Carcinoma, Ductal
Immunoexpression of HER family, neuregulin, MAPK and AKT in invasive ductal carcinomas of the breast.
Carcinoma, Ductal
Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis.
Carcinoma, Ductal
Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.
Carcinoma, Ductal
Protein kinase D1 inhibits breast cancer cell invasion via regulating matrix metalloproteinase expression.
Carcinoma, Ductal
Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex.
Carcinoma, Ductal
Proteomic Analysis of Urine to Identify Breast Cancer Biomarker Candidates Using a Label-Free LC-MS/MS Approach.
Carcinoma, Ductal
The differential expression of aqueous soluble proteins in breast normal and cancerous tissues in relation to ethnicity of the patients; Chinese, Malay and Indian.
Carcinoma, Ductal, Breast
Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma.
Carcinoma, Ehrlich Tumor
Characterization of highly phosphorylated subcomponents of rat thymus H1 histone.
Carcinoma, Ehrlich Tumor
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Carcinoma, Ehrlich Tumor
Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing.
Carcinoma, Ehrlich Tumor
Phosphorylation is involved in the regulation of the taurine influx via the beta-system in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Purification and characterization of a 400-kDa nonhistone chromatin protein that serves as an effective phosphate acceptor for casein kinase II from Ehrlich ascites tumor cells.
Carcinoma, Embryonal
14-3-3 protein family members have a regulatory role in retinoic acid-mediated induction of cytokeratins in F9 cells.
Carcinoma, Embryonal
Cyclic AMP response element-binding protein and the catalytic subunit of protein kinase A are present in F9 embryonal carcinoma cells but are unable to activate the somatostatin promoter.
Carcinoma, Embryonal
G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation.
Carcinoma, Embryonal
Human testis phosphoproteome reveals kinases as potential targets in spermatogenesis and testicular cancer.
Carcinoma, Embryonal
Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis.
Carcinoma, Embryonal
MEKK4 mediates differentiation in response to retinoic acid via activation of c-Jun N-terminal kinase in rat embryonal carcinoma P19 cells.
Carcinoma, Embryonal
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells.
Carcinoma, Endometrioid
beta-catenin expression pattern in stage I and II ovarian carcinomas : relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome.
Carcinoma, Endometrioid
Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma.
Carcinoma, Endometrioid
[Correlations between the p-Akt-mTOR-p70S6K pathway and clinicopathological features or chemoresistance of ovarian cancer].
Carcinoma, Hepatocellular
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
Carcinoma, Hepatocellular
7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-?B, MMP2, and MMP9 Expression.
Carcinoma, Hepatocellular
8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK.
Carcinoma, Hepatocellular
A ?Raf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures.
Carcinoma, Hepatocellular
A novel anti-cancer substance, MK615, from ume, a variety of Japanese apricot, inhibits growth of hepatocellular carcinoma cells by suppressing Aurora A kinase activity.
Carcinoma, Hepatocellular
A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish.
Carcinoma, Hepatocellular
A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis.
Carcinoma, Hepatocellular
A novel casein kinase 2 alpha-subunit regulates membrane protein traffic in the human hepatoma cell line HuH-7.
Carcinoma, Hepatocellular
A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility.
Carcinoma, Hepatocellular
A novel mechanism of hepatocellular carcinoma cell apoptosis induced by lupeol via Brain-Derived Neurotrophic Factor Inhibition and Glycogen Synthase Kinase 3 beta reactivation.
Carcinoma, Hepatocellular
A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.
Carcinoma, Hepatocellular
A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma.
Carcinoma, Hepatocellular
A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.
Carcinoma, Hepatocellular
A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase.
Carcinoma, Hepatocellular
A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.
Carcinoma, Hepatocellular
A single-center experience of sorafenib monotherapy in patients with advanced intrahepatic cholangiocarcinoma.
Carcinoma, Hepatocellular
A-kinase anchoring protein 12 is downregulated in human hepatocellular carcinoma and its deficiency in mice aggravates thioacetamide-induced liver injury.
Carcinoma, Hepatocellular
A-kinase interacting protein 1 (AKIP1) associates with advanced overall disease condition, tumor properties, and unfavorable prognosis in hepatocellular carcinoma patients.
Carcinoma, Hepatocellular
Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.
Carcinoma, Hepatocellular
Absolute Structures of Wedelolide Derivatives and Structure-Activity Relationships of Protein Tyrosine Phosphatase 1B Inhibitory ent-Kaurene Diterpenes from Aerial Parts of Wedelia spp. Collected in Indonesia and Japan.
Carcinoma, Hepatocellular
Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver.
Carcinoma, Hepatocellular
Activation of AMP-activated Protein Kinase and Phosphorylation of Glycogen Synthase Kinase3 ? Mediate Ursolic Acid Induced Apoptosis in HepG2 Liver Cancer Cells.
Carcinoma, Hepatocellular
Activation of c-Jun N-terminal kinase in non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Activation of casein kinase II in response to insulin and to epidermal growth factor.
Carcinoma, Hepatocellular
Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene.
Carcinoma, Hepatocellular
Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin.
Carcinoma, Hepatocellular
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Carcinoma, Hepatocellular
Adiponectin induces apoptosis in hepatocellular carcinoma through differential modulation of thioredoxin proteins.
Carcinoma, Hepatocellular
Adiponectin modulates C-jun N-terminal kinase and Mammalian target of rapamycin and inhibits hepatocellular carcinoma.
Carcinoma, Hepatocellular
AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma.
Carcinoma, Hepatocellular
AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade.
Carcinoma, Hepatocellular
Alterations of beta-catenin and Tcf-4 instead of GSK-3beta contribute to activation of Wnt pathway in hepatocellular carcinoma.
Carcinoma, Hepatocellular
An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.
Carcinoma, Hepatocellular
Analysis of possible mechanisms accounting for raf-1 kinase inhibitor protein downregulation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Anti-malarial atovaquone exhibits anti-tumor effects by inducing DNA damage in hepatocellular carcinoma.
Carcinoma, Hepatocellular
ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.
Carcinoma, Hepatocellular
Ataxia telangiectasia mutated inhibitor-loaded copper sulfide nanoparticles for low-temperature photothermal therapy of hepatocellular carcinoma.
Carcinoma, Hepatocellular
ATGL promotes the proliferation of hepatocellular carcinoma cells via the p-AKT signaling pathway.
Carcinoma, Hepatocellular
Aurora-A Overexpression in Mouse Liver Causes p53-Dependent Premitotic Arrest during Liver Regeneration.
Carcinoma, Hepatocellular
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer.
Carcinoma, Hepatocellular
Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability.
Carcinoma, Hepatocellular
AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Basic fibroblast growth factor upregulates survivin expression in hepatocellular carcinoma cells via a protein kinase B-dependent pathway.
Carcinoma, Hepatocellular
BAY-43-9006 Bayer/Onyx.
Carcinoma, Hepatocellular
Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling.
Carcinoma, Hepatocellular
c-Jun N-terminal kinase inhibitor favors transforming growth factor?? to antagonize hepatitis B virus X protein?induced cell growth promotion in hepatocellular carcinoma.
Carcinoma, Hepatocellular
C/EBP? is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.
Carcinoma, Hepatocellular
CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1? in Hepatoma Cells.
Carcinoma, Hepatocellular
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Carcinoma, Hepatocellular
Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Clinacanthus nutans (Burm. f.) Lindau Ethanol Extract Inhibits Hepatoma in Mice through Upregulation of the Immune Response.
Carcinoma, Hepatocellular
Clinical significance of serum 14-3-3 beta in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.
Carcinoma, Hepatocellular
Cloning of sgk serine-threonine protein kinase from shark rectal gland - a gene induced by hypertonicity and secretagogues
Carcinoma, Hepatocellular
Co-Upregulation of 14-3-3? and P-Akt is Associated with Oncogenesis and Recurrence of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Combretastatin A-4 disodium phosphate and low dose gamma irradiation suppress hepatocellular carcinoma by downregulating ROCK1 and VEGF gene expression.
Carcinoma, Hepatocellular
Complexes formation between insulin receptor and extracellular signal-regulated kinases ERKs.
Carcinoma, Hepatocellular
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Constancy of expression of the protein kinase A regulatory subunit R1 alpha in hepatoma cell lines of different phenotypes.
Carcinoma, Hepatocellular
Correction to Induction of Apoptosis by the Anthocyanidins through Regulation of Bcl-2 Gene and Activation of c-Jun N-Terminal Kinase Cascade in Hepatoma Cells.
Carcinoma, Hepatocellular
Correlation between loss of PTEN expression and PKB/AKT phosphorylation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Cross-species identification of in silico microsatellite biomarkers for genetic disease.
Carcinoma, Hepatocellular
Cryptotanshinone (Dsh-003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2-induced survival and invasion effects in HA22T hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Death-associated protein kinase 1 suppresses hepatocellular carcinoma cell migration and invasion by upregulation of DEAD-box helicase 20.
Carcinoma, Hepatocellular
Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies.
Carcinoma, Hepatocellular
Differential regulation of AKT1 contributes to survival and proliferation in hepatocellular carcinoma cells by mediating Notch1 expression.
Carcinoma, Hepatocellular
DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-?B pathway.
Carcinoma, Hepatocellular
DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line.
Carcinoma, Hepatocellular
Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway.
Carcinoma, Hepatocellular
Downregulation of Raf-1 kinase inhibitory protein as a sorafenib resistance mechanism in hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Early skin toxicity as a predictive factor for tumor control in hepatocellular carcinoma patients treated with sorafenib.
Carcinoma, Hepatocellular
Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase.
Carcinoma, Hepatocellular
Effect of adenosine 3':5'-cyclic monophosphate and inhibition of protein kinase A on heat sensitivity in H35 hepatoma cells.
Carcinoma, Hepatocellular
Effect of Glucuronidation on the Potential of Kaempferol To Inhibit Serine/Threonine Protein Kinases.
Carcinoma, Hepatocellular
Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
Enhancing the clinical activity of sorafenib through dose escalation: rationale and current experience.
Carcinoma, Hepatocellular
Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation.
Carcinoma, Hepatocellular
Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferator activated receptors.
Carcinoma, Hepatocellular
Expression and prognostic role of pan-Ras, Raf-1, pMEK1 and pERK1/2 in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression of Concern: Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration and invasion in human hepatoma carcinoma by upregulating ROCK1.
Carcinoma, Hepatocellular
Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4.
Carcinoma, Hepatocellular
Expression of Raf kinase inhibitor protein in human hepatoma tissues by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight methods.
Carcinoma, Hepatocellular
FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells.
Carcinoma, Hepatocellular
Fibrolamellar carcinoma: A histologically unique tumor with unique molecular findings.
Carcinoma, Hepatocellular
Focal adhesion kinase affects the sensitivity of human hepatocellular carcinoma cell line SMMC-7721 to tumor necrosis factor-alpha/cycloheximide-induced apoptosis by regulating protein kinase B levels.
Carcinoma, Hepatocellular
Frequent beta-catenin aberration in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation.
Carcinoma, Hepatocellular
Genetic screen identifies suppressor of morphogenesis in genitalia-1 (SMG-1) as a modulator of sorafenib resistance in hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells.
Carcinoma, Hepatocellular
Glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells.
Carcinoma, Hepatocellular
Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation.
Carcinoma, Hepatocellular
Glycogen synthase kinase-3beta negatively regulates group IIA phospholipase A2 expression in human aortic smooth muscle and HepG2 hepatoma cells.
Carcinoma, Hepatocellular
Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
GSK-3beta phosphorylation and alteration of beta-catenin in hepatocellular carcinoma.
Carcinoma, Hepatocellular
GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.
Carcinoma, Hepatocellular
h-sgk serine-threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells.
Carcinoma, Hepatocellular
Heat shock, protein synthesis and ribosomal protein S6 phosphorylation in vitro in Yoshida AH 130 ascites hepatoma cells.
Carcinoma, Hepatocellular
High expression of PFTK1 in cancer cells predicts poor prognosis in colorectal cancer.
Carcinoma, Hepatocellular
Higher expression of A-kinase anchoring-protein 1 predicts poor prognosis in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Higher tumor protein kinase D1 correlates with increased tumor size, BCLC stage, CA199 level, AFP level and worse overall survival in hepatocellular carcinoma patients.
Carcinoma, Hepatocellular
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.
Carcinoma, Hepatocellular
HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1?.
Carcinoma, Hepatocellular
Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.
Carcinoma, Hepatocellular
Human sulfatase-1 inhibits the migration and proliferation of SMMC-7721 hepatocellular carcinoma cells by downregulating the growth factor signaling.
Carcinoma, Hepatocellular
Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation.
Carcinoma, Hepatocellular
IC261 suppresses progression of hepatocellular carcinoma in a casein kinase 1 ?/? independent manner.
Carcinoma, Hepatocellular
Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Identification of the Amino Acids 300-600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573.
Carcinoma, Hepatocellular
Induction of apoptosis by the Anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells.
Carcinoma, Hepatocellular
Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death.
Carcinoma, Hepatocellular
Inhibition of exendin-4-induced steatosis by protein kinase A in cultured HepG2 human hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression.
Carcinoma, Hepatocellular
Inhibition of GSK-3? activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling.
Carcinoma, Hepatocellular
Inhibition of Raf-1 kinase expression abolishes insulin stimulation of DNA synthesis in H4IIE hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of the JNK signaling pathway increases sensitivity of hepatocellular carcinoma cells to cisplatin by down-regulating expression of P-glycoprotein.
Carcinoma, Hepatocellular
Insulin action inhibits insulin-like growth factor-II (IGF-II) receptor phosphorylation in H-35 hepatoma cells. IGF-II receptors isolated from insulin-treated cells exhibit enhanced in vitro phosphorylation by casein kinase II.
Carcinoma, Hepatocellular
Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide.
Carcinoma, Hepatocellular
Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells.
Carcinoma, Hepatocellular
Interleukin-1 regulation of corticotropin-releasing factor (CRF), glucocorticoid receptor, c-fos and c-jun messenger RNA in the NPLC-KC cell line.
Carcinoma, Hepatocellular
Interleukin-33/ST2 Signaling Promotes Hepatocellular Carcinoma Cell Stemness Expansion Through Activating c-Jun N-terminal Kinase Pathway.
Carcinoma, Hepatocellular
Involvement of 14-3-3 Proteins in Regulating Tumor Progression of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Involvement of 3',5'-cyclic adenosine monophosphate regulatory element binding protein (CREB) in both basal and hormone-mediated expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene.
Carcinoma, Hepatocellular
IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation.
Carcinoma, Hepatocellular
Isolation of a complementary DNA encoding the catalytic subunit of protein kinase A and studies on the expression of this sequence in rat hepatomas and regenerating liver.
Carcinoma, Hepatocellular
Knockdown of receptor-interacting serine/threonine protein kinase-2 (RIPK2) affects EMT-associated gene expression in human hepatoma cells.
Carcinoma, Hepatocellular
Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.
Carcinoma, Hepatocellular
LINC00339 regulates ROCK1 by miR-152 to promote cell proliferation and migration in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Lipoprotein lipase expression in undifferentiated hepatoma cells is regulated by progesterone and protein kinase A.
Carcinoma, Hepatocellular
Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
lncRNA TINCR sponges miR-214-5p to upregulate ROCK1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration and invasion in human hepatoma carcinoma by upregulating ROCK1.
Carcinoma, Hepatocellular
Long noncoding RNA AURKAPS1 potentiates malignant hepatocellular carcinoma progression by regulating miR-142, miR-155 and miR-182.
Carcinoma, Hepatocellular
Long Noncoding RNAs Coregulated by Annexin A7 and JNK in Hepatocellular Carcinoma Cells Identified by Whole-Genome Expression Profiling.
Carcinoma, Hepatocellular
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells.
Carcinoma, Hepatocellular
Low cytoplasmic casein kinase 1 epsilon expression predicts poor prognosis in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
MEK/ERK pathway is positively involved in hypoxia-induced vasculogenic mimicry formation in hepatocellular carcinoma which is regulated negatively by protein kinase A.
Carcinoma, Hepatocellular
Methylation of the ataxia telangiectasia mutated gene (ATM) promoter as a radiotherapy outcome biomarker in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
microRNA-148a-3p enhances the effects of sevoflurane on hepatocellular carcinoma cell progression via ROCK1 repression.
Carcinoma, Hepatocellular
MicroRNA-26b-5p enhances T cell responses by targeting PIM-2 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
MiR-145 suppresses cell proliferation and motility by inhibiting ROCK1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
MiR-199a/b-5p inhibits hepatocellular carcinoma progression by post-transcriptionally suppressing ROCK1.
Carcinoma, Hepatocellular
MiR-335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
NAD(P)H Quinone Dehydrogenase 1 Ablation Inhibits Activation of the Phosphoinositide 3-Kinase/Akt Serine/Threonine Kinase and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathways and Blocks Metabolic Adaptation in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Neurotensin as a source of cyclic AMP and co-mitogen in fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
Nickel and copper ion-induced stress signaling in human hepatoma cells: analysis of phosphoinositide 3'-kinase/Akt signaling.
Carcinoma, Hepatocellular
NUCKS1 Acts as a Promising Novel Biomarker for the Prognosis of Patients with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma.
Carcinoma, Hepatocellular
Overexpression of PEMT2 downregulates the PI3K/Akt signaling pathway in rat hepatoma cells.
Carcinoma, Hepatocellular
Participation of a MEK-independent pathway in MAP kinase activation and modulation of cell growth in mouse hepatoma cell lines.
Carcinoma, Hepatocellular
Perfluorooctane sulfonate-induced insulin resistance is mediated by protein kinase B pathway.
Carcinoma, Hepatocellular
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma.
Carcinoma, Hepatocellular
Phosphorylation of hepatic AMP-activated protein kinase and liver kinase B1 is increased after a single oral dose of green tea extract to mice.
Carcinoma, Hepatocellular
Phosphorylation of isolated plasma membranes of AH-66 hepatoma ascites cells by casein kinase 1.
Carcinoma, Hepatocellular
Phosphorylation of the pyruvate dehydrogenase complex precedes HIF-1-mediated effects and pyruvate dehydrogenase kinase 1 upregulation during the first hours of hypoxic treatment in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Pim-2 Activates API-5 to Inhibit the Apoptosis of Hepatocellular Carcinoma Cells Through NF-kappaB Pathway.
Carcinoma, Hepatocellular
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.
Carcinoma, Hepatocellular
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Carcinoma, Hepatocellular
Prognostic significance of death-associated protein-kinase expression in hepatocellular carcinomas.
Carcinoma, Hepatocellular
Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Carcinoma, Hepatocellular
Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo.
Carcinoma, Hepatocellular
Protein kinase D2 contributes to TNF-?-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3?/?-catenin pathway in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Protein synthesis, ribosomal protein S6 phosphorylation in vitro and the effects of amiloride: SDS gel electrophoresis studies in the Yoshida ascites tumor (AH 130) grown in vivo.
Carcinoma, Hepatocellular
Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sativus) seeds.
Carcinoma, Hepatocellular
Quantitative Proteomics Reveals That the Inhibition of Na(+)/K(+)-ATPase Activity Affects S-Phase Progression Leading to a Chromosome Segregation Disorder by Attenuating the Aurora A Function in Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Hepatocellular
Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Raf kinase inhibitor protein mediated signaling inhibits invasion and metastasis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Rat primary hepatocytes and H4 hepatoma cells display differential sensitivity to cyclic AMP at the level of expression of tyrosine aminotransferase.
Carcinoma, Hepatocellular
Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
Carcinoma, Hepatocellular
Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.
Carcinoma, Hepatocellular
Regulation of insulin receptor kinase by multisite phosphorylation.
Carcinoma, Hepatocellular
Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect.
Carcinoma, Hepatocellular
Relationship between functional polymorphism in the Aurora A gene and susceptibility of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Retraction Note: lncRNA TINCR sponges miR-214-5p to upregulate ROCK1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
Carcinoma, Hepatocellular
Rock2 promotes the invasion and metastasis of hepatocellular carcinoma by modifying MMP2 ubiquitination and degradation.
Carcinoma, Hepatocellular
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
Carcinoma, Hepatocellular
Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development.
Carcinoma, Hepatocellular
Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis.
Carcinoma, Hepatocellular
Role of MAP kinases and their cross-talk in TGF-beta1-induced apoptosis in FaO rat hepatoma cell line.
Carcinoma, Hepatocellular
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Carcinoma, Hepatocellular
Role of Raf Kinase Inhibitor Protein in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Selection of patients with hepatocellular carcinoma for sorafenib.
Carcinoma, Hepatocellular
Serine/Threonine Kinase Pim-2 Promotes Liver Tumorigenesis Induction Through Mediating Survival and Preventing Apoptosis of Liver Cell.
Carcinoma, Hepatocellular
SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3?/?-catenin signaling in HCC cells.
Carcinoma, Hepatocellular
Significant and Durable Clinical Response to Sorafenib and Radiation Therapy for a Patient With Stage IV Hepatocellular Carcinoma and LRRK2 Mutation.
Carcinoma, Hepatocellular
Silencing of 14-3-3? over-expression in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium.
Carcinoma, Hepatocellular
Sorafenib in advanced hepatocellular carcinoma: current status and future perspectives.
Carcinoma, Hepatocellular
Sorafenib inhibits migration and invasion of hepatocellular carcinoma cells through suppression of matrix metalloproteinase expression.
Carcinoma, Hepatocellular
Sorafenib inhibits the hepatocyte growth factor-mediated epithelial mesenchymal transition in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/?-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.
Carcinoma, Hepatocellular
Sphingoid bases from sea cucumber induce apoptosis in human hepatoma HepG2 cells through p-AKT and DR5.
Carcinoma, Hepatocellular
Stable knockdown of protein kinase CK2-alpha (CK2?) inhibits migration and invasion and induces inactivation of hedgehog signaling pathway in hepatocellular carcinoma Hep G2 cells.
Carcinoma, Hepatocellular
STAT3 and beta-catenin signaling pathway may affect GSK-3beta expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
STK33 promotes hepatocellular carcinoma through binding to c-Myc.
Carcinoma, Hepatocellular
Structures of the PKA RI? Holoenzyme with the FLHCC Driver J-PKAc? or Wild-Type PKAc?.
Carcinoma, Hepatocellular
STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.
Carcinoma, Hepatocellular
Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer.
Carcinoma, Hepatocellular
Targeted Gene Silencing BRAF Synergized Photothermal Effect Inhibits Hepatoma Cell Growth Using New GAL-GNR-siBRAF Nanosystem.
Carcinoma, Hepatocellular
Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel.
Carcinoma, Hepatocellular
Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells.
Carcinoma, Hepatocellular
The alpha-isoform of the CCAAT/enhancer-binding protein is required for mediating cAMP responsiveness of the phosphoenolpyruvate carboxykinase promoter in hepatoma cells.
Carcinoma, Hepatocellular
The effects of urotensin II on migration and invasion are mediated by NADPH oxidase-derived reactive oxygen species through the c-Jun N-terminal kinase pathway in human hepatoma cells.
Carcinoma, Hepatocellular
The ménage à trois of autophagy, lipid droplets and liver disease.
Carcinoma, Hepatocellular
The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation.
Carcinoma, Hepatocellular
The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells.
Carcinoma, Hepatocellular
Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-?1 /Smad2/3 pathway.
Carcinoma, Hepatocellular
Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
Transforming growth factor-beta1 stimulated protein kinase B serine-473 and focal adhesion kinase tyrosine phosphorylation dependent on cell adhesion in human hepatocellular carcinoma SMMC-7721 cells.
Carcinoma, Hepatocellular
TRB3 reverses chemotherapy resistance and mediates crosstalk between endoplasmic reticulum stress and AKT signaling pathways in MHCC97H human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Tumor DNA-dependent protein kinase catalytic subunit expression is associated with hepatitis B surface antigen status and tumor progression in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Carcinoma, Hepatocellular
Upregulation of 14-3-3 eta in chronic liver fluke infection is a potential diagnostic marker of cholangiocarcinoma.
Carcinoma, Hepatocellular
Upregulation of Stress-Induced Protein Kinase CK1 Delta is associated with a Poor Prognosis for patients with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation.
Carcinoma, Hepatocellular
VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin.
Carcinoma, Hepatocellular
Wogonin inhibits cell cycle progression by activating the glycogen synthase kinase-3 beta in hepatocellular carcinoma.
Carcinoma, Hepatocellular
ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line.
Carcinoma, Hepatocellular
[Expression of Pim-2 in normal liver and hepatocellular carcinoma tissues]
Carcinoma, Hepatocellular
[Expressions of Raf-1 kinase, phosphorylated mitogen extracellular kinase 1, and phosphorylated extracellular signal-regulated protein kinase 1/2 in hepatocellular carcinoma and their relationship with prognosis]
Carcinoma, Hepatocellular
[Knockdown of DNA-PKcs inhibits cell cycle and its mechanism of drug-resistant Bel7402/5-Fu hepatocellular carcinoma cells].
Carcinoma, Hepatocellular
[Preliminary study of dihydroartemisin in inhibiting invasion and metastasis of hepatoma cells].
Carcinoma, Hepatocellular
[Protein kinases and phospholipids in human hepatocellular carcinoma]
Carcinoma, Hepatocellular
[Serum-and-glucocorticoid-inducible-kinase-2 is overexpressed and mediates glycogen synthase kinase-3?/ ?-catenin signal transduction in hepatocellular carcinoma].
Carcinoma, Hepatocellular
[The effect and clinical significance of methylation of 14-3-3 sigma gene in hepatitis B virus-related hepatocellular carcinoma]
Carcinoma, Hepatocellular
[The role and significance of Wnt/beta-catenin signaling pathway regulating the signaling molecules in hepatocellular carcinoma.].
Carcinoma, Intraductal, Noninfiltrating
14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling.
Carcinoma, Intraductal, Noninfiltrating
Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Carcinoma, Intraductal, Noninfiltrating
Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis.
Carcinoma, Intraductal, Noninfiltrating
Promoter hypermethylation in ductal carcinoma in situ of the male breast.
Carcinoma, Large Cell
Correlation between STK33 and the pathology and prognosis of lung cancer.
Carcinoma, Large Cell
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines.]
Carcinoma, Lewis Lung
Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells.
Carcinoma, Lewis Lung
Activation of the protein kinase a signal transduction pathway by granulocyte-macrophage colony-stimulating factor or by genetic manipulation reduces cytoskeletal organization in Lewis lung carcinoma variants.
Carcinoma, Lewis Lung
Granulocyte-macrophage colony-stimulating factor stimulates the metastatic properties of Lewis lung carcinoma cells through a protein kinase A signal-transduction pathway.
Carcinoma, Lewis Lung
Protein kinase A regulates Lewis lung carcinoma adherence to extracellular matrix components and spontaneous metastasis.
Carcinoma, Lewis Lung
Protein phosphatases limit tumor motility.
Carcinoma, Lewis Lung
Protein phosphatases-1 and -2A regulate tumor cell migration, invasion and cytoskeletal organization.
Carcinoma, Lewis Lung
Regulation of Lewis lung carcinoma invasion and metastasis by protein kinase A.
Carcinoma, Lewis Lung
Regulation of protein kinase A activation and prostaglandin E2-stimulated migration of Lewis lung carcinoma clones.
Carcinoma, Lewis Lung
The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor.
Carcinoma, Lewis Lung
Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A.
Carcinoma, Lobular
Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer.
Carcinoma, Lobular
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Carcinoma, Medullary
STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary-Mucinous Carcinoma of the Transverse Colon.
Carcinoma, Mucoepidermoid
EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas.
Carcinoma, Mucoepidermoid
Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma.
Carcinoma, Neuroendocrine
Durable response to combination radiotherapy and immunotherapy in EP-resistant lung large-cell neuroendocrine carcinoma with B2M and STK11 mutations: a case report.
Carcinoma, Non-Small-Cell Lung
?-Catulin drives metastasis by activating ILK and driving an ?v?3 integrin signaling axis.
Carcinoma, Non-Small-Cell Lung
A detailed smoking history and determination of MYC status predict response to checkpoint inhibitors in advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
A p38?-Selective Chemosensor for use in Unfractionated Cell Lysates.
Carcinoma, Non-Small-Cell Lung
A randomized, phase 2 evaluation of the CHK1 inhibitor, LY2603618, administered in combination with pemetrexed and cisplatin in patients with advanced nonsquamous non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens.
Carcinoma, Non-Small-Cell Lung
Advances in anti-BRAF therapies for lung cancer.
Carcinoma, Non-Small-Cell Lung
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
ANXA1-GSK3? interaction and its involvement in NSCLC metastasis.
Carcinoma, Non-Small-Cell Lung
Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Association of EGFR and KRAS mutations with expression of p-AKT, DR5 and DcR1 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy.
Carcinoma, Non-Small-Cell Lung
Association of protein kinase CK2 inhibition with cellular radiosensitivity of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
ATM gene polymorphisms are associated with poor prognosis of non-small cell lung cancer receiving radiation therapy.
Carcinoma, Non-Small-Cell Lung
Aurora A, aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Aurora kinase inhibitors as anti-cancer therapy.
Carcinoma, Non-Small-Cell Lung
cAMP signaling increases histone deacetylase 8 expression via the Epac2-Rap1A-Akt pathway in H1299 lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Characterization of Aurora A and Its Impact on the Effect of Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3.
Carcinoma, Non-Small-Cell Lung
Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPK? signaling in STK11 mutant lung cancer.
Carcinoma, Non-Small-Cell Lung
Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Combinations of laminin 5 with PTEN, p-EGFR and p-Akt define a group of distinct molecular subsets indicative of poor prognosis in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
DNA-dependent protein kinase: effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines.
Carcinoma, Non-Small-Cell Lung
Elevated expression of G3BP1 associates with YB1 and p-AKT and predicts poor prognosis in nonsmall cell lung cancer patients after surgical resection.
Carcinoma, Non-Small-Cell Lung
EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells.
Carcinoma, Non-Small-Cell Lung
Evading the STING: LKB1 Loss Leads to STING Silencing and Immune Escape in KRAS-Mutant Lung Cancers.
Carcinoma, Non-Small-Cell Lung
Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2.
Carcinoma, Non-Small-Cell Lung
Expression of phosphorylated mTOR and its clinical significances in small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases.
Carcinoma, Non-Small-Cell Lung
Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated.
Carcinoma, Non-Small-Cell Lung
Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients.
Carcinoma, Non-Small-Cell Lung
Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.
Carcinoma, Non-Small-Cell Lung
GSK-3? inhibits autophagy and enhances radiosensitivity in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.
Carcinoma, Non-Small-Cell Lung
Inhibition of c-Jun N-terminal kinase signaling increased apoptosis and prevented the emergence of ALK-TKI-tolerant cells in ALK-rearranged non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Inhibition of protein kinase CK2 sensitizes non-small cell lung cancer cells to cisplatin via upregulation of PML.
Carcinoma, Non-Small-Cell Lung
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Interaction of ribosomal protein L22 with casein kinase 2?: a novel mechanism for understanding the biology of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Interleukin-22 (IL-22) Regulates Apoptosis of Paclitaxel-Resistant Non-Small Cell Lung Cancer Cells Through C-Jun N-Terminal Kinase Signaling Pathway.
Carcinoma, Non-Small-Cell Lung
Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells.
Carcinoma, Non-Small-Cell Lung
Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
Carcinoma, Non-Small-Cell Lung
Knocking Down Nucleolin Expression Enhances the Radiosensitivity of Non-Small Cell Lung Cancer by Influencing DNA-PKcs Activity.
Carcinoma, Non-Small-Cell Lung
KRAS: Reasons for optimism in lung cancer.
Carcinoma, Non-Small-Cell Lung
Kruppel-like factor 4 inhibits non-small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-?1-meidated ERK/JNK/NF-?B signaling pathways.
Carcinoma, Non-Small-Cell Lung
LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor.
Carcinoma, Non-Small-Cell Lung
Long duration of immunotherapy in a STK11 mutated/KRAS wild-type non-small cell lung cancer patient.
Carcinoma, Non-Small-Cell Lung
MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
MicroRNA-137-regulated AKT serine/threonine kinase 2 inhibits tumor growth and sensitizes cisplatin in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
MicroRNA-148a suppresses epithelial-to-mesenchymal transition by targeting ROCK1 in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein.
Carcinoma, Non-Small-Cell Lung
miR-193a-3p inhibition of the Slug activator PAK4 suppresses non-small cell lung cancer aggressiveness via the p53/Slug/L1CAM pathway.
Carcinoma, Non-Small-Cell Lung
miR-335-5p inhibits TGF-?1-induced epithelial-mesenchymal transition in non-small cell lung cancer via ROCK1.
Carcinoma, Non-Small-Cell Lung
miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression.
Carcinoma, Non-Small-Cell Lung
Multiple primary malignant neoplasms: A case report and literature review.
Carcinoma, Non-Small-Cell Lung
Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11.
Carcinoma, Non-Small-Cell Lung
Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
Carcinoma, Non-Small-Cell Lung
Nuclear survivin and its relationship to DNA damage repair genes in non-small cell lung cancer investigated using tissue array.
Carcinoma, Non-Small-Cell Lung
Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion.
Carcinoma, Non-Small-Cell Lung
PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
PIM1-activated PRAS40 regulates radioresistance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases.
Carcinoma, Non-Small-Cell Lung
Primary Resistance to Immune Checkpoint Blockade in an STK11/TP53/KRAS-Mutant Lung Adenocarcinoma with High PD-L1 Expression.
Carcinoma, Non-Small-Cell Lung
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of nuclear or cytoplasmic nucleolin expression in human non-small cell lung cancer and its relationship with DNA-PKcs.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic value of phospho-Akt in patients with non-small cell lung carcinoma: A meta-analysis.
Carcinoma, Non-Small-Cell Lung
Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers.
Carcinoma, Non-Small-Cell Lung
Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Protein Kinase D1 Is Increased in Tumor Tissue, Correlates With Advanced Tumor Features and Worse Prognosis of Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Non-Small-Cell Lung
Reduced RKIP expression levels are associated with frequent non-small cell lung cancer metastasis and STAT3 phosphorylation and activation.
Carcinoma, Non-Small-Cell Lung
Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
Carcinoma, Non-Small-Cell Lung
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Carcinoma, Non-Small-Cell Lung
ROCK1 and ROCK2 are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion.
Carcinoma, Non-Small-Cell Lung
Role of next generation sequencing-based liquid biopsy in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: impact of STK11, KRAS and TP53 mutations and co-mutations on outcome.
Carcinoma, Non-Small-Cell Lung
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Carcinoma, Non-Small-Cell Lung
Selective expression and immunogenicity of the cancer/testis antigens SP17, AKAP4 and PTTG1 in non-small cell lung cancer: new candidates for active immunotherapy.
Carcinoma, Non-Small-Cell Lung
STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort.
Carcinoma, Non-Small-Cell Lung
STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling.
Carcinoma, Non-Small-Cell Lung
Survival analysis for non-squamous NSCLC patients harbored STK11 or KEAP1 mutation receiving atezolizumab.
Carcinoma, Non-Small-Cell Lung
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
Carcinoma, Non-Small-Cell Lung
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Carcinoma, Non-Small-Cell Lung
The effect of ionizing radiation on the subcellular localization and kinase activity of protein kinase CK2 in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
The influence of STK11 mutation on acquired resistance to immunotherapy in advanced non-small cell lung cancer with Lynch syndrome: a case report and literature review.
Carcinoma, Non-Small-Cell Lung
The role of the c-Jun N-terminal kinase 2-?-isoform in non-small cell lung carcinoma tumorigenesis.
Carcinoma, Non-Small-Cell Lung
Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
WEE1 Kinase Inhibitor AZD1775 Has Preclinical Efficacy in LKB1-Deficient Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines.]
Carcinoma, Non-Small-Cell Lung
[Correlation of P27 expression and localization to phosphorylated AKT in non-small cell lung cancer]
Carcinoma, Non-Small-Cell Lung
[Current status of Akt in non-small cell lung cancer].
Carcinoma, Non-Small-Cell Lung
[Expression and clinical significance of Ku70, Ku80 and DNA-PKcs proteins in patients with stageI-II non-small cell lung cancer by tissue microarray.]
Carcinoma, Non-Small-Cell Lung
[Prognostic value of combined expression of Aurora A, p53 and p21 WAF1 in patients after curative resection of non-small cell lung cancer].
Carcinoma, Non-Small-Cell Lung
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
Carcinoma, Non-Small-Cell Lung
[The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.]
Carcinoma, Non-Small-Cell Lung
[The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.]
Carcinoma, Ovarian Epithelial
14-3-3 zeta protein secreted by tumor associated monocytes/macrophages from ascites of epithelial ovarian cancer patients.
Carcinoma, Ovarian Epithelial
A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells.
Carcinoma, Ovarian Epithelial
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Carcinoma, Ovarian Epithelial
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
Carcinoma, Ovarian Epithelial
BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers.
Carcinoma, Ovarian Epithelial
Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells.
Carcinoma, Ovarian Epithelial
Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines.
Carcinoma, Ovarian Epithelial
Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma.
Carcinoma, Ovarian Epithelial
Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature.
Carcinoma, Ovarian Epithelial
Clinicopathological and biological significance of aberrant activation of glycogen synthase kinase-3 in ovarian cancer.
Carcinoma, Ovarian Epithelial
Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation.
Carcinoma, Ovarian Epithelial
Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients.
Carcinoma, Ovarian Epithelial
Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.
Carcinoma, Ovarian Epithelial
Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib Via Regulation of Rad-51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells.
Carcinoma, Ovarian Epithelial
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
Carcinoma, Ovarian Epithelial
Gonadotropins activate proteolysis and increase invasion through protein kinase A and phosphatidylinositol 3-kinase pathways in human epithelial ovarian cancer cells.
Carcinoma, Ovarian Epithelial
Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Investigating the clinical potential for 14-3-3 zeta protein to serve as a biomarker for epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
LC-MS/MS Analysis of Ovarian Cancer Metastasis-Related Proteins Using a Nude Mouse Model: 14-3-3 Zeta as a Candidate Biomarker.
Carcinoma, Ovarian Epithelial
Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity.
Carcinoma, Ovarian Epithelial
TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2? as a therapeutic target.
Carcinoma, Ovarian Epithelial
[Expression of phosphorylated protein kinase B and PTEN protein in ovarian epithelial cancer]
Carcinoma, Pancreatic Ductal
Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.
Carcinoma, Papillary
14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.
Carcinoma, Papillary
Caveolin-1 and 14-3-3 sigma expression in follicular variant of thyroid papillary carcinoma.
Carcinoma, Papillary
Expression of down stream molecules of RET (p-ERK, p-p38 MAPK, p-JNK and p-AKT) in papillary thyroid carcinomas.
Carcinoma, Papillary
The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.
Carcinoma, Papillary
[BRAF gene mutation in the natural history of papillary thyroid carcinoma: diagnostic and prognostic implications].
Carcinoma, Renal Cell
14-3-3 protein beta/alpha as a urinary biomarker for renal cell carcinoma: proteomic analysis of cyst fluid.
Carcinoma, Renal Cell
A-kinase interacting protein 1 high expression correlates with advanced tumor stage and poor overall survival in surgical patients with clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Author Correction: Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma, Renal Cell
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer.
Carcinoma, Renal Cell
Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis.
Carcinoma, Renal Cell
Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma.
Carcinoma, Renal Cell
Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Cyclin-Dependent Kinase Inhibitor BMI-1026 Induces Apoptosis by Downregulating Mcl-1 (L) and c-FLIP (L) and Inactivating p-Akt in Human Renal Carcinoma Cells.
Carcinoma, Renal Cell
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene.
Carcinoma, Renal Cell
Differential expression of the subunits of the glucose-6-phosphatase system in the clear cell type of human renal cell carcinoma - no evidence for an overexpression of protein kinase B.
Carcinoma, Renal Cell
Dual inhibition of DNA-PKcs and mTOR by CC-115 potently inhibits human renal cell carcinoma cell growth.
Carcinoma, Renal Cell
Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways.
Carcinoma, Renal Cell
Editorial comment on: Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinoma, Renal Cell
Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma.
Carcinoma, Renal Cell
G Protein Alpha S Subunit Promotes Cell Proliferation of Renal Cell Carcinoma with Involvement of Protein Kinase A Signaling.
Carcinoma, Renal Cell
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion.
Carcinoma, Renal Cell
Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma.
Carcinoma, Renal Cell
GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.
Carcinoma, Renal Cell
GSK-3 inhibition in vitro and in vivo enhances antitumor effect of sorafenib in renal cell carcinoma (RCC).
Carcinoma, Renal Cell
Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3.
Carcinoma, Renal Cell
Increased Activated Akt Expression in Renal Cell Carcinomas and Prognosis.
Carcinoma, Renal Cell
Incremental Expression of 14-3-3 Protein Beta/Alpha in Urine Correlates with Advanced Stage and Poor Survival in Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
LRRK2 is a candidate prognostic biomarker for clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Methylation of STK11 promoter is a risk factor for tumor stage and survival in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma.
Carcinoma, Renal Cell
Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2? expression and cell proliferation.
Carcinoma, Renal Cell
Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis.
Carcinoma, Renal Cell
p-AKT overexpression in primary renal cell carcinomas and their metastases.
Carcinoma, Renal Cell
p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Phase I trial of everolimus plus sorafenib for patients with advanced renal cell cancer.
Carcinoma, Renal Cell
Pyrvinium Sensitizes Clear Cell Renal Cell Carcinoma Response to Chemotherapy Via Casein Kinase 1?-Dependent Inhibition of Wnt/?-Catenin.
Carcinoma, Renal Cell
Quantitative protein expression profiling of 14-3-3 isoforms in human renal carcinoma shows 14-3-3 epsilon is involved in limitedly increasing renal cell proliferation.
Carcinoma, Renal Cell
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Renal Cell
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma, Renal Cell
Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting GSK-3?.
Carcinoma, Renal Cell
Recent advances in the research and development of RAF kinase inhibitors.
Carcinoma, Renal Cell
Reduced expression of Raf-1 kinase inhibitory protein in renal cell carcinoma: a significant prognostic marker.
Carcinoma, Renal Cell
Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a?p-AKT-dependent manner.
Carcinoma, Renal Cell
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Thompson JM, Nguyen QH, Singh M, Pavesic MW, Nesterenko I, Nelson LJ, Liao AC, Razorenova OV.
Carcinoma, Renal Cell
RIalpha Influences Cellular Proliferation in Cancer Cells by Transporting RFC40 into the Nucleus.
Carcinoma, Renal Cell
Ribosomal s6 protein kinase 4: a prognostic factor for renal cell carcinoma.
Carcinoma, Renal Cell
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Carcinoma, Renal Cell
Sorafenib stimulates human skin type mast cell degranulation and maturation.
Carcinoma, Renal Cell
Sorafenib-associated remission of psoriasis in hypernephroma: case report.
Carcinoma, Renal Cell
The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.
Carcinoma, Renal Cell
The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.
Carcinoma, Renal Cell
The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
Carcinoma, Renal Cell
The putative tumour suppressor microRNA-145, repressed by c-jun, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
Carcinoma, Renal Cell
Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinoma, Renal Cell
VX680/MK-0457, a potent and selective Aurora kinase inhibitor, targets both tumor and endothelial cells in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
[Study of the expression of Aurora kinases in renal cell carcinoma].
Carcinoma, Small Cell
Correlation between STK33 and the pathology and prognosis of lung cancer.
Carcinoma, Small Cell
Expression of phosphorylated Akt in patients with small cell carcinoma of the lung indicates good prognosis.
Carcinoma, Small Cell
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinoma, Squamous Cell
14-3-3? silencing retards tongue squamous cell carcinoma progression by inhibiting cell survival and migration.
Carcinoma, Squamous Cell
A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.
Carcinoma, Squamous Cell
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Carcinoma, Squamous Cell
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
Carcinoma, Squamous Cell
Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Antisense oligonucleotides against protein kinase CK2-alpha inhibit growth of squamous cell carcinoma of the head and neck in vitro.
Carcinoma, Squamous Cell
Association of elevated protein kinase CK2 activity with aggressive behavior of squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells.
Carcinoma, Squamous Cell
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Carcinoma, Squamous Cell
Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation.
Carcinoma, Squamous Cell
Casein kinase II alpha subunit and C1-inhibitor are independent predictors of outcome in patients with squamous cell carcinoma of the lung.
Carcinoma, Squamous Cell
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Carcinoma, Squamous Cell
Clinical significance of 14-3-3 zeta in human esophageal cancer.
Carcinoma, Squamous Cell
Clinicopathological features and prognostic implications of Raf kinase inhibitor protein downregulation in tongue squamous cell carcinoma.
Carcinoma, Squamous Cell
Clinicopathological significance of ribosomal protein S6 kinase A6 in lung squamous cell carcinoma: an immunohistochemical and RNA-seq study.
Carcinoma, Squamous Cell
Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia.
Carcinoma, Squamous Cell
Constitutive modulation of Raf-1 protein kinase is associated with differential gene expression of several known and unknown genes.
Carcinoma, Squamous Cell
Correlation between STK33 and the pathology and prognosis of lung cancer.
Carcinoma, Squamous Cell
Correlation of constitutive activation of raf-1 with morphological transformation and abrogation of tyrosine phosphorylation of distinct sets of proteins in human squamous carcinoma cells.
Carcinoma, Squamous Cell
CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer.
Carcinoma, Squamous Cell
Decreased expression of 14-3-3 ?, an early event of malignant transformation of respiratory epithelium, also facilitates progression of squamous cell lung cancer.
Carcinoma, Squamous Cell
Differential expression of ras signal transduction mediators in verrucous and squamous cell carcinomas of the upper aerodigestive tract.
Carcinoma, Squamous Cell
Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-?1/Smad Signaling Pathway.
Carcinoma, Squamous Cell
Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival.
Carcinoma, Squamous Cell
Effect of DJ-1 overexpression on the proliferation, apoptosis, invasion and migration of laryngeal squamous cell carcinoma SNU-46 cells through PI3K/AKT/mTOR.
Carcinoma, Squamous Cell
Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.
Carcinoma, Squamous Cell
Evaluation of Prexasertib, a Checkpoint Kinase 1 Inhibitor, in a Phase Ib Study of Patients with Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Evaluation of protein kinase CK2 as a therapeutic target for squamous cell carcinoma of cats.
Carcinoma, Squamous Cell
Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma.
Carcinoma, Squamous Cell
Expression and Significance of RKIP and E-cadherin in Lung Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Carcinoma, Squamous Cell
Expression of cyclin D1 and GSK-3beta and their predictive value of prognosis in squamous cell carcinomas of the tongue.
Carcinoma, Squamous Cell
Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
Carcinoma, Squamous Cell
Expression of protein tyrosine kinases in head and neck squamous cell carcinomas.
Carcinoma, Squamous Cell
Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition.
Carcinoma, Squamous Cell
Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.
Carcinoma, Squamous Cell
Functional characterization of transforming growth factor beta type II receptor mutants in human cancer.
Carcinoma, Squamous Cell
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Carcinoma, Squamous Cell
Histamine inhibits the production of interferon-induced protein of 10 kDa in human squamous cell carcinoma and melanoma.
Carcinoma, Squamous Cell
Identificating 14-3-3 sigma as a lymph node metastasis-related protein in human lung squamous carcinoma.
Carcinoma, Squamous Cell
Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.
Carcinoma, Squamous Cell
Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes.
Carcinoma, Squamous Cell
Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells.
Carcinoma, Squamous Cell
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Carcinoma, Squamous Cell
Interferon-?-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway.
Carcinoma, Squamous Cell
Keratin 17 is co-expressed with 14-3-3 sigma in oral carcinoma in situ and squamous cell carcinoma and modulates cell proliferation and size but not cell migration.
Carcinoma, Squamous Cell
KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
Carcinoma, Squamous Cell
lncRNA HAND2-AS1 inhibits cancer cell proliferation, migration and invasion by downregulating ROCK1 in HPV-positive and negative cervical squamous cell carcinoma.
Carcinoma, Squamous Cell
Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1.
Carcinoma, Squamous Cell
MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer.
Carcinoma, Squamous Cell
Microvesicles Contribute to the Bystander Effect of DNA Damage.
Carcinoma, Squamous Cell
Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study.
Carcinoma, Squamous Cell
Mutational analysis of the HIPK2 gene in keratoacanthoma and squamous cell carcinoma of the skin.
Carcinoma, Squamous Cell
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
Carcinoma, Squamous Cell
Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells.
Carcinoma, Squamous Cell
Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.
Carcinoma, Squamous Cell
Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis.
Carcinoma, Squamous Cell
p63 regulates growth of esophageal squamous carcinoma cells via the Akt signaling pathway.
Carcinoma, Squamous Cell
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Carcinoma, Squamous Cell
PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations.
Carcinoma, Squamous Cell
Phospho-?Np63?-dependent regulation of autophagic signaling through transcription and micro-RNA modulation.
Carcinoma, Squamous Cell
Phosphorylated p63 induces transcription of regulatory particle non ATP-ase subunit 13 and nitric oxide synthase-2 protein degradation.
Carcinoma, Squamous Cell
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Carcinoma, Squamous Cell
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinoma, Squamous Cell
Protein kinase C deficiency blocks recovery from agonist-induced desensitization.
Carcinoma, Squamous Cell
Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells.
Carcinoma, Squamous Cell
Proteome analysis in the clinical chemistry laboratory: myth or reality?
Carcinoma, Squamous Cell
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Squamous Cell
Raf kinase inhibitor protein expression correlates with differentiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma.
Carcinoma, Squamous Cell
Raf-1 and squamous cell carcinoma: Rok-ing the boat.
Carcinoma, Squamous Cell
Reversal effect of Raf-1/Mdr-1 siRNAs co-transfection on multidrug resistance in KBv200 cell line.
Carcinoma, Squamous Cell
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
Carcinoma, Squamous Cell
ROCK1 as a novel prognostic marker in vulvar cancer.
Carcinoma, Squamous Cell
STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Carcinoma, Squamous Cell
Targeting 14-3-3?-CDC25A interactions to trigger apoptotic cell death in skin cancer.
Carcinoma, Squamous Cell
The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas.
Carcinoma, Squamous Cell
The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro.
Carcinoma, Squamous Cell
The Mammalian Target of Rapamycin-70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors.
Carcinoma, Squamous Cell
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Carcinoma, Squamous Cell
TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Whole Exome Profiling of NSCLC Among African Americans.
Carcinoma, Squamous Cell
[Diagnostic value of protein markers in plasma exosomes of lung squamous cell carcinoma].
Carcinoma, Squamous Cell
[Effects of salinomycin on proliferation and apoptosis of oral squamous cell carcinoma].
Carcinoma, Squamous Cell
[Role of protein kinase D1 in regulating the growth, apoptosis and drug sensitivity of oral squamous carcinoma cells].
Carcinoma, Squamous Cell
[The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma]
Carcinoma, Transitional Cell
Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c?Raf/MEK/ERK signaling pathway.
Carcinoma, Transitional Cell
Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition.
Carcinoma, Transitional Cell
Hypermethylation-mediated partial transcriptional silencing of DAP-kinase gene in bladder cancer.
Carcinoma, Transitional Cell
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis.
Carcinoma, Transitional Cell
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinoma, Transitional Cell
Selective reovirus killing of bladder cancer in a co-culture spheroid model.
Carcinoma, Verrucous
Differential expression of ras signal transduction mediators in verrucous and squamous cell carcinomas of the upper aerodigestive tract.
Cardiac Conduction System Disease
Developmental changes in expression of myotonic dystrophy protein kinase in the rat central nervous system.
Cardiac Conduction System Disease
Enhanced serum immunoglobulin G clearance in myotonic dystrophy-associated hypogammaglobulinemia: a case series and review of the literature.
Cardiomegaly
"Jnking" atherosclerosis.
Cardiomegaly
(-)-Epicatechin induces physiological cardiac growth by activation of the pi3k/akt pathway in mice.
Cardiomegaly
2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation.
Cardiomegaly
A CaMKII/PDE4D negative feedback regulates cAMP signaling.
Cardiomegaly
A novel protein kinase C target site in protein kinase D is phosphorylated in response to signals for cardiac hypertrophy.
Cardiomegaly
A Rare Connection: Fasciculoventricular Pathway in PRKAG2 Disease.
Cardiomegaly
A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy.
Cardiomegaly
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.
Cardiomegaly
Activation of transient receptor potential vanilloid 3 channel (TRPV3) aggravated pathological cardiac hypertrophy via calcineurin/NFATc3 pathway in rats.
Cardiomegaly
Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts.
Cardiomegaly
AKAP signaling complexes: getting to the heart of the matter.
Cardiomegaly
AMPK blunts chronic heart failure by inhibiting autophagy.
Cardiomegaly
AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1.
Cardiomegaly
AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol.
Cardiomegaly
Angiotensin II mediates mechanical stress-induced cardiac hypertrophy.
Cardiomegaly
Angiotensin II-induced cardiac hypertrophy is associated with different mitogen-activated protein kinase activation in normotensive and hypertensive mice.
Cardiomegaly
Angiotensin-(1-7) stimulates high atrial pacing-induced ANP secretion via Mas/PI3-kinase/Akt axis and Na+/H+ exchanger.
Cardiomegaly
Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.
Cardiomegaly
Arrhythmogenic ?-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII.
Cardiomegaly
Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population.
Cardiomegaly
Astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing Ca²?-mediated calcineurin/NFATc3 and CaMKII signaling cascades.
Cardiomegaly
Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli.
Cardiomegaly
Atorvastatin reverses cardiac remodeling possibly through regulation of Protein Kinase D/Myocyte Enhancer Factor 2D activation in spontaneously hypertensive rats.
Cardiomegaly
Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males.
Cardiomegaly
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart.
Cardiomegaly
Ca2+/calmodulin-dependent protein kinase II increases the susceptibility to the arrhythmogenic action potential alternans in spontaneously hypertensive rats.
Cardiomegaly
Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.
Cardiomegaly
Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.
Cardiomegaly
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.
Cardiomegaly
CaMKII exacerbates heart failure progression by activating class I HDACs.
Cardiomegaly
CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice.
Cardiomegaly
CaMKII: The molecular villain that aggravates cardiovascular disease.
Cardiomegaly
CaMKIIdelta orchestrates G protein coupled receptor and electric field stimulation-induced cardiomyocyte hypertrophy.
Cardiomegaly
Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras, and Ca2+/Calmodulin-Dependent Protein Kinase II Signaling.
Cardiomegaly
Carboxyl-Terminal Modulator Protein Ameliorates Pathological Cardiac Hypertrophy by Suppressing the Protein Kinase B Signaling Pathway.
Cardiomegaly
Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription.
Cardiomegaly
Cardioprotection of an IK1 channel agonist on L-thyroxine induced rat ventricular remodeling.
Cardiomegaly
Carvedilol reverses cardiac insufficiency in AKAP5 knockout mice by normalizing the activities of calcineurin and CaMKII.
Cardiomegaly
Casein Kinase-2 Interacting Protein-1 Regulates Physiological Cardiac Hypertrophy via Inhibition of Histone Deacetylase 4 Phosphorylation.
Cardiomegaly
Caspase recruitment domain 6 protects against cardiac hypertrophy in response to pressure overload.
Cardiomegaly
Caveolae-specific activation loop between CaMKII and L-type Ca(2+) channel aggravates cardiac hypertrophy in ?1-adrenergic stimulation.
Cardiomegaly
Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy.
Cardiomegaly
Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins.
Cardiomegaly
Control of histone H3 phosphorylation by CaMKII? in response to haemodynamic cardiac stress.
Cardiomegaly
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
Cardiomegaly
Decoding the cardiac actions of protein kinase D isoforms.
Cardiomegaly
Decreased glycogen synthase kinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages.
Cardiomegaly
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
Cardiomegaly
Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy.
Cardiomegaly
Disparate Regulation of Signaling Proteins after Exercise and Myocardial Infarction.
Cardiomegaly
Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy.
Cardiomegaly
Distinct roles of calmodulin and Ca2+/calmodulin-dependent protein kinase II in isopreterenol-induced cardiac hypertrophy.
Cardiomegaly
Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.
Cardiomegaly
DOCA-induced phosphorylation of glycogen synthase kinase 3beta.
Cardiomegaly
DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities.
Cardiomegaly
Early apoptosis in different models of cardiac hypertrophy induced by high renin-angiotensin system activity involves CaMKII.
Cardiomegaly
Effect of inhibition of glycogen synthase kinase-3 on cardiac hypertrophy during acute pressure overload.
Cardiomegaly
Egr-1 mediated cardiac miR-99 family expression diverges physiological hypertrophy from pathological hypertrophy.
Cardiomegaly
Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.
Cardiomegaly
Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload
Cardiomegaly
Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload.
Cardiomegaly
Experimental antiarrhythmic targets: CaMKII inhibition - Ready for clinical evaluation?
Cardiomegaly
Expression of Ca2+/calmodulin-dependent protein kinase II delta-subunit isoforms in rats with hypertensive cardiac hypertrophy.
Cardiomegaly
Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis.
Cardiomegaly
Fas receptor signaling inhibits glycogen synthase kinase 3 beta and induces cardiac hypertrophy following pressure overload.
Cardiomegaly
Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes.
Cardiomegaly
Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol.
Cardiomegaly
Glycogen synthase kinase-3beta is involved in the process of myocardial hypertrophy stimulated by insulin-like growth factor-1.
Cardiomegaly
Glycogen synthase kinase-3beta negatively regulates TGF-beta1 and Angiotensin II-mediated cellular activity through interaction with Smad3.
Cardiomegaly
Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins.
Cardiomegaly
Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.
Cardiomegaly
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Cardiomegaly
Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats.
Cardiomegaly
ILK induces cardiomyogenesis in the human heart.
Cardiomegaly
Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes.
Cardiomegaly
Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor.
Cardiomegaly
Inhibition of nitric oxide synthesis induces coronary vascular remodeling and cardiac hypertrophy associated with the activation of p70 S6 kinase in rats.
Cardiomegaly
Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid.
Cardiomegaly
Integrated mechanisms of CaMKII-dependent ventricular remodeling.
Cardiomegaly
Intermedin alleviates pathological cardiac remodeling by upregulating klotho.
Cardiomegaly
Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy.
Cardiomegaly
Is CaMKII a link between inflammation and hypertrophy in heart?
Cardiomegaly
JIP3 deficiency attenuates cardiac hypertrophy by suppression of JNK pathway.
Cardiomegaly
Knockout of p21-activated kinase-1 attenuates exercise-induced cardiac remodelling through altered calcineurin signalling.
Cardiomegaly
Kv4.3 expression abrogates and reverses norepinephrine-induced myocyte hypertrophy by CaMKII inhibition.
Cardiomegaly
LncRNA TINCR attenuates cardiac hypertrophy by epigenetically silencing CaMKII.
Cardiomegaly
mAKAP? signalosomes - A nodal regulator of gene transcription associated with pathological cardiac remodeling.
Cardiomegaly
MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.
Cardiomegaly
miR-337-5p promotes the development of cardiac hypertrophy by targeting Ubiquilin-1 (UBQLN1).
Cardiomegaly
MiR-625-5p Inhibits Cardiac Hypertrophy Through Targeting STAT3 and CaMKII.
Cardiomegaly
Molecular aspects of mechanical stress-induced cardiac hypertrophy.
Cardiomegaly
MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction.
Cardiomegaly
Myofibroblast ?2 adrenergic signaling amplifies cardiac hypertrophy in mice.
Cardiomegaly
Na+/H+ exchanger isoform 1 induced cardiomyocyte hypertrophy involves activation of p90 ribosomal s6 kinase.
Cardiomegaly
Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy.
Cardiomegaly
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
Cardiomegaly
Novel regulators and drug targets of cardiac hypertrophy.
Cardiomegaly
Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.
Cardiomegaly
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.
Cardiomegaly
Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.
Cardiomegaly
Phosphoinositide 3-kinase ? inhibits cardiac GSK-3 independently of Akt.
Cardiomegaly
Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.
Cardiomegaly
PKD deletion promotes autophagy and inhibits hypertrophy in cardiomyocyte.
Cardiomegaly
PKD knockdown inhibits pressure overload-induced cardiac hypertrophy by promoting autophagy via AKT/mTOR pathway.
Cardiomegaly
Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.
Cardiomegaly
Promotion and inhibition of cardiac hypertrophy by A-kinase anchor proteins.
Cardiomegaly
Protein Kinases as Drug Development Targets for Heart Disease Therapy.
Cardiomegaly
Quercetin prevents cardiac hypertrophy induced by pressure overload in rats.
Cardiomegaly
Rad GTPase deficiency leads to cardiac hypertrophy.
Cardiomegaly
Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload.
Cardiomegaly
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes.
Cardiomegaly
Repolarizing cardiac potassium channels: Multiple sites and mechanisms for CaMKII-mediated regulation.
Cardiomegaly
ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice.
Cardiomegaly
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure.
Cardiomegaly
Role of CaMKII for signaling and regulation in the heart.
Cardiomegaly
Roles of cyclooxygenase-2 and phosphorylated Akt (Thr308) in cardiac hypertrophy regression mediated by left-ventricular unloading.
Cardiomegaly
Roles of Glycogen Synthase Kinase-3 (GSK-3) in Cardiac Development and Heart Disease.
Cardiomegaly
Simvastatin Protects Heart from Pressure Overload Injury by Inhibiting Excessive Autophagy.
Cardiomegaly
Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy.
Cardiomegaly
Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy.
Cardiomegaly
Small-conductance Ca2+-activated K+ current is upregulated via the phosphorylation of CaMKII in cardiac hypertrophy from spontaneously hypertensive rats.
Cardiomegaly
Structural and Mechanistic Bases of Nuclear Calcium Signaling in Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes.
Cardiomegaly
Sustained increased CaMKII phosphorylation is involved in the impaired regression of isoproterenol-induced cardiac hypertrophy in rats.
Cardiomegaly
Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.
Cardiomegaly
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis.
Cardiomegaly
Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis.
Cardiomegaly
Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy.
Cardiomegaly
TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells.
Cardiomegaly
The ?A isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway.
Cardiomegaly
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
Cardiomegaly
The combined inhibition of the CaMKII? and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
Cardiomegaly
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.
Cardiomegaly
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease.
Cardiomegaly
The Mammalian Ste20-like Kinase 2 (Mst2) Modulates Stress-induced Cardiac Hypertrophy.
Cardiomegaly
The potential role of Kv4.3 K(+) channel in heart hypertrophy.
Cardiomegaly
The role of protein kinase D (PKD) in intracellular nutrient sensing and regulation of adaptive responses to the obese environment.
Cardiomegaly
The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism.
Cardiomegaly
The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-Lbc.
Cardiomegaly
The Wnt/frizzled/GSK-3beta pathway: a novel therapeutic target for cardiac hypertrophy.
Cardiomegaly
Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation.
Cardiomegaly
Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes.
Cardiomegaly
Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation.
Cardiomegaly
Transient outward potassium channel: a heart failure mediator.
Cardiomegaly
TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice.
Cardiomegaly
Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.
Cardiomegaly
Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.
Cardiomegaly
Upregulation of IGF-IIR? intensifies doxorubicin-induced cardiac damage.
Cardiomegaly
Urotensin II induction of adult cardiomyocytes hypertrophy involves the Akt/GSK-3beta signaling pathway.
Cardiomegaly
Vitexin protects against cardiac hypertrophy via inhibiting calcineurin and CaMKII signaling pathways.
Cardiomegaly
ZAK? antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAK?.
Cardiomegaly
[Oxidative stress and calcium/calmodulin-dependent protein kinase II contribute to the development of sustained ? adrenergic receptor-stimulated cardiac hypertrophy in rats].
Cardiomegaly
[Role of glycogen synthase kinase-3beta in cardiac hypertrophy and cardiocyte apoptosis]
Cardiomyopathies
Alterations in protein kinase A and protein kinase C levels in heart failure due to genetic cardiomyopathy.
Cardiomyopathies
Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-?B pathway.
Cardiomyopathies
Ca(2+) /calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy.
Cardiomyopathies
Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.
Cardiomyopathies
Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.
Cardiomyopathies
Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein.
Cardiomyopathies
CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression.
Cardiomyopathies
CaMKII-?9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair.
Cardiomyopathies
Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine.
Cardiomyopathies
Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase Signaling.
Cardiomyopathies
Cardioprotective role of GTS-21 by attenuating the TLR4/NF-?B pathway in streptozotocin-induced diabetic cardiomyopathy in rats.
Cardiomyopathies
Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy.
Cardiomyopathies
Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies.
Cardiomyopathies
Crosstalk between GSK-3?-actuated molecular cascades and myocardial physiology.
Cardiomyopathies
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
Cardiomyopathies
Diminished Cardiac Fibrosis in Heart Failure is Associated with Altered Ventricular Arrhythmia Phenotype.
Cardiomyopathies
Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy.
Cardiomyopathies
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Cardiomyopathies
GRK5 Controls SAP97-Dependent Cardiotoxic ?1 Adrenergic Receptor-CaMKII Signaling in Heart Failure.
Cardiomyopathies
Huoxue Wentong Formula ameliorates myocardial infarction in rats through inhibiting CaMKII oxidation and phosphorylation.
Cardiomyopathies
Impaired angiotensin II-extracellular signal-regulated kinase signaling in failing human ventricular myocytes.
Cardiomyopathies
Inactivation of GSK-3{beta} by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage and remodeling.
Cardiomyopathies
Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.
Cardiomyopathies
Interaction of ?1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling.
Cardiomyopathies
Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.
Cardiomyopathies
MiR-141 attenuates sepsis-induced cardiomyopathy by targeting DAPK1.
Cardiomyopathies
Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice.
Cardiomyopathies
Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
Cardiomyopathies
Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.
Cardiomyopathies
PCP4 regulates Purkinje cell excitability and cardiac rhythmicity.
Cardiomyopathies
Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene.
Cardiomyopathies
Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.
Cardiomyopathies
Quantitative proteomic analysis reveals high interference on protein expression of H9c2 cells activated with glucose and cardiotonic steroids.
Cardiomyopathies
Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.
Cardiomyopathies
The combined inhibition of the CaMKII? and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
Cardiomyopathies
The GSK-3 family as therapeutic target for myocardial diseases.
Cardiomyopathy, Alcoholic
Valsartan inhibits RhoA-ROCK2-MYL pathway in rat model of alcoholic cardiomyopathy.
Cardiomyopathy, Dilated
2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.
Cardiomyopathy, Dilated
2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation.
Cardiomyopathy, Dilated
Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy.
Cardiomyopathy, Dilated
Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.
Cardiomyopathy, Dilated
All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation.
Cardiomyopathy, Dilated
Ca(2+) /calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy.
Cardiomyopathy, Dilated
Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.
Cardiomyopathy, Dilated
Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation.
Cardiomyopathy, Dilated
Emerging Role for RBM20 and Its Splicing Substrates in Cardiac Function and Heart Failure.
Cardiomyopathy, Dilated
Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.
Cardiomyopathy, Dilated
Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy.
Cardiomyopathy, Dilated
Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.
Cardiomyopathy, Dilated
Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.
Cardiomyopathy, Dilated
NMR solution structure and topological orientation of monomeric phospholamban in dodecylphosphocholine micelles.
Cardiomyopathy, Dilated
Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene.
Cardiomyopathy, Dilated
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1.
Cardiomyopathy, Dilated
Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy.
Cardiomyopathy, Dilated
Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation.
Cardiomyopathy, Dilated
The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity.
Cardiomyopathy, Dilated
The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics.
Cardiomyopathy, Dilated
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.
Cardiomyopathy, Hypertrophic
Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C.
Cardiomyopathy, Hypertrophic
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation.
Cardiomyopathy, Hypertrophic
Exploring miRNA-mRNA regulatory network in cardiac pathology in Na+/H+ exchanger isoform 1 transgenic mice.
Cardiomyopathy, Hypertrophic
Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic
Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D.
Cardiomyopathy, Hypertrophic
Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
Cardiomyopathy, Hypertrophic
Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.
Cardiomyopathy, Hypertrophic
Selective phosphorylation of PKA targets after ?-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.
Cardiomyopathy, Restrictive
Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.
Cardiomyopathy, Restrictive
Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.
Cardiomyopathy, Restrictive
Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.
Cardiotoxicity
Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity.
Cardiotoxicity
CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression.
Cardiotoxicity
CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes.
Cardiotoxicity
Cardiotoxicity of sorafenib is mediated through elevation of ROS level and CaMKII activity and dysregulation of calcium homeostasis.
Cardiotoxicity
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy.
Cardiotoxicity
Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity.
Cardiotoxicity
Effects of acute and chronic sunitinib treatment on cardiac function and calcium/calmodulin-dependent protein kinase II.
Cardiotoxicity
Investigation of the mechanism of the reduction of anthracycline-induced cardiotoxicity by Qishen Huanwu Capsule based on network pharmacology.
Cardiotoxicity
Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II.
Cardiovascular Diseases
A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases.
Cardiovascular Diseases
AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease.
Cardiovascular Diseases
An Overview of the Role of Calcium/Calmodulin-Dependent Protein Kinase in Cardiorenal Syndrome.
Cardiovascular Diseases
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.
Cardiovascular Diseases
Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3/CamKII dependent pathway.
Cardiovascular Diseases
c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.
Cardiovascular Diseases
CaMKII in the cardiovascular system: sensing redox states.
Cardiovascular Diseases
CaMKII: The molecular villain that aggravates cardiovascular disease.
Cardiovascular Diseases
CaMKII? post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes.
Cardiovascular Diseases
Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis.
Cardiovascular Diseases
Designing of the N-ethyl-4-(pyridin-4-yl)benzamide based potent ROCK1 inhibitors using docking, molecular dynamics, and 3D-QSAR.
Cardiovascular Diseases
DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis.
Cardiovascular Diseases
Effects of heterologous expression of human cyclic nucleotide Phosphodiesterase 3A (hPDE3A) on redox regulation in yeast.
Cardiovascular Diseases
Elaborate ligand-based modeling reveal new submicromolar Rho kinase inhibitors.
Cardiovascular Diseases
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.
Cardiovascular Diseases
Human muscle-specific A-kinase anchoring protein (mAKAP) polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/ PKA signaling.
Cardiovascular Diseases
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3?.
Cardiovascular Diseases
IGF-2R-G?q signalling and cardiac hypertrophy in the low birth weight lamb.
Cardiovascular Diseases
Inhibition of Rho-kinase stimulates nitric oxide-independent vasorelaxation.
Cardiovascular Diseases
Interaction of ?1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling.
Cardiovascular Diseases
Intervention Mechanisms of Xinmailong Injection, a Periplaneta Americana Extract, on Cardiovascular Disease: A Systematic Review of Basic Researches.
Cardiovascular Diseases
Mechanisms of CaMKII Activation in the Heart.
Cardiovascular Diseases
Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II.
Cardiovascular Diseases
Na(+)/K(+)-ATPase inhibition by ouabain induces CaMKII-dependent apoptosis in adult rat cardiac myocytes.
Cardiovascular Diseases
Oxidative CaMKII as a potential target for inflammatory disease (Review).
Cardiovascular Diseases
Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.
Cardiovascular Diseases
p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus.
Cardiovascular Diseases
Peptide Substrates for Rho-Associated Kinase 2 (Rho-Kinase 2/ROCK2).
Cardiovascular Diseases
Physiological role of ROCKs in the cardiovascular system.
Cardiovascular Diseases
Receptor-interacting protein 2 (RIP2) gene polymorphisms are associated with increased risk of subclinical atherosclerosis and clinical and metabolic parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican study.
Cardiovascular Diseases
Regulation of CaMKII signaling in cardiovascular disease.
Cardiovascular Diseases
Role of CaMKII in cardiac arrhythmias.
Cardiovascular Diseases
Role of CaMKII in free fatty acid/hyperlipidemia-induced cardiac remodeling both in vitro and in vivo.
Cardiovascular Diseases
Scutellarin exerts its anti-hypertrophic effects via suppressing the Ca2+-mediated calcineurin and CaMKII signaling pathways.
Cardiovascular Diseases
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Cardiovascular Diseases
The 14-3-3 proteins in regulation of cellular metabolism.
Cardiovascular Diseases
The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study.
Cardiovascular Diseases
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Cardiovascular Diseases
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease.
Cardiovascular Diseases
Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway.
Cardiovascular Diseases
Transcriptome and Functional Profile of Cardiac Myocytes Is Influenced by Biological Sex.
Cardiovascular Diseases
ZYZ-803, a novel hydrogen sulfide-nitric oxide conjugated donor, promotes angiogenesis via cross-talk between STAT3 and CaMKII.
Carney Complex
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia.
Carney Complex
8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors.
Carney Complex
A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.
Carney Complex
A Novel PRKAR1A Mutation Identified in a Patient with Isolated Primary Pigmented Nodular Adrenocortical Disease.
Carney Complex
A pleiomorphic GH pituitary adenoma from a Carney complex patient displays universal allelic loss at the protein kinase A regulatory subunit 1A (PRKARIA) locus.
Carney Complex
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Carney Complex
Anesthetic experiences of myxoma removal surgery in two patients with Carney complex -A report of two cases-.
Carney Complex
Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog.
Carney Complex
Carney complex and McCune Albright syndrome: An overview of clinical manifestations and human molecular genetics.
Carney Complex
Carney Complex.
Carney Complex
Carney complex: Clinical and genetic 2010 update.
Carney Complex
Carney complex: the first 20 years.
Carney Complex
Clinical and molecular genetic studies of bilateral adrenal hyperplasias.
Carney Complex
Clinical genetics of multiple endocrine neoplasias, Carney complex and related syndromes.
Carney Complex
Clinical phenotypes and molecular genetic mechanisms of Carney complex.
Carney Complex
Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease.
Carney Complex
Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.
Carney Complex
Familial pituitary tumors.
Carney Complex
Frequent Phosphodiesterase 11A Gene (PDE11A) Defects in Patients with Carney Complex (CNC) Caused by PRKAR1A Mutations: PDE11A May Contribute to Adrenal and Testicular Tumors in CNC as a Modifier of the Phenotype.
Carney Complex
Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex.
Carney Complex
G-protein and signalling in pituitary tumours.
Carney Complex
Gastrointestinal polyps in McCune Albright syndrome.
Carney Complex
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
Carney Complex
Germline deletion and a somatic mutation of the PRKAR1A gene in a Carney complex-related pituitary adenoma.
Carney Complex
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
Carney Complex
Human tumors associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease!
Carney Complex
In Vitro Studies of Novel PRKAR1A Mutants that Extend the Predicted RI? Protein Sequence into the 3'-Untranslated Open Reading Frame: Proteasomal Degradation Leads to RI? Haploinsufficiency and Carney Complex.
Carney Complex
Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters.
Carney Complex
Inherited disposition to cardiac myxoma development.
Carney Complex
Knockdown of PRKAR1A, the Gene Responsible for Carney Complex, Interferes With Differentiation in Osteoblastic Cells.
Carney Complex
Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.
Carney Complex
Maxillary sinus melanoma as the presenting feature of Carney complex.
Carney Complex
Melanotic nonpsammomatous trigeminal schwannoma as the first manifestation of Carney complex: case report.
Carney Complex
Melanotic Schwannoma of the Vulva: A Case Report and Review of the Literature.
Carney Complex
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Carney Complex
MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling.
Carney Complex
Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas.
Carney Complex
Molecular genetic advances in pituitary tumor development.
Carney Complex
Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A.
Carney Complex
Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex.
Carney Complex
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.
Carney Complex
Myxoma of the ear lobe in a 23-month-old girl with Carney complex.
Carney Complex
New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors.
Carney Complex
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Carney Complex
Pathology of the adrenal cortex: a reappraisal of the past 25 years focusing on adrenal cortical tumors.
Carney Complex
Primary pigmented nodular adrenocortical disease reveals insulin-like growth factor binding protein-2 regulation by protein kinase A.
Carney Complex
PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.
Carney Complex
PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes.
Carney Complex
PRKAR1A mutation causing pituitary-dependent Cushing disease in a patient with Carney complex.
Carney Complex
Protein kinase A and its role in human neoplasia: the Carney complex paradigm.
Carney Complex
Protein kinase A and tumorigenicity: the example of micronodular adrenocortical hyperplasia and Carney complex.
Carney Complex
Protein kinase A in Carney complex: a new example of cAMP pathway alteration in endocrine tumors.
Carney Complex
Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.
Carney Complex
Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.
Carney Complex
Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.
Carney Complex
Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.
Carney Complex
The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.
Carney Complex
The genetics of pituitary adenomas.
Carney Complex
The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis.
Carney Complex
[Familial pituitary adenomas: clinical and genetic aspects].
Carney Complex
[PRKAR1A gene mutations in two patients with myxoma syndrome (Carney complex)]
Carotid Artery Injuries
Tumor Suppressor Serine/Threonine Kinase LKB1 Expression, Not Kinase Activity, Increased in the Vascular Smooth Muscle Cells and Neointima in the Rat Carotid Artery Injury Model.
caspase-9 deficiency
Caspase-9 acts as a regulator of necroptotic cell death.
Cataract
Enhanced serum immunoglobulin G clearance in myotonic dystrophy-associated hypogammaglobulinemia: a case series and review of the literature.
Cataract
High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene.
Cataract
Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A.
Cell Transformation, Neoplastic
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Cell Transformation, Neoplastic
Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.
Cell Transformation, Neoplastic
Long-term culture of human gingival keratinocyte progenitor cells by down-regulation of 14-3-3 sigma.
Cell Transformation, Neoplastic
Raf and RhoA cooperate to transform intestinal epithelial cells and induce growth resistance to transforming growth factor beta.
Cell Transformation, Neoplastic
Relationship between functional polymorphism in the Aurora A gene and susceptibility of hepatocellular carcinoma.
Central Nervous System Diseases
14-3-3 adaptor protein-protein interactions as therapeutic targets for CNS diseases.
Central Nervous System Diseases
14-3-3 protein in CSF: an early predictor of SIV CNS disease.
Central Nervous System Diseases
A unique type of GSK-3 inhibitor brings new opportunities to the clinic.
Central Nervous System Diseases
Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants.
Central Nervous System Diseases
Control of JNK for an activation of NADPH oxidase in LPS-stimulated BV2 microglia.
Central Nervous System Diseases
Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.
Central Nervous System Diseases
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Central Nervous System Diseases
Laboratory diagnosis of central nervous system infections.
Central Nervous System Diseases
Mechanism of delayed encephalopathy after acute carbon monoxide poisoning.
Central Nervous System Diseases
Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Central Nervous System Diseases
Potential involvement of glycogen synthase kinase (GSK)-3? in a rat model of multiple sclerosis: evidenced by lithium treatment.
Central Nervous System Diseases
Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases.
Central Nervous System Diseases
RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L.
Central Nervous System Diseases
The Possible Involvement of Glycogen Synthase Kinase-3 (GSK-3) in Diabetes, Cancer and Central Nervous System Diseases.
Central Nervous System Infections
Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase.
Central Nervous System Infections
Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease.
Cerebellar Ataxia
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Cerebellar Ataxia
Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease.
Cerebellar Ataxia
Cutaneous Granulomatosis and Class Switching Defect as a Presenting Sign in Ataxia-Telangiectasia: First Case from the National Iranian Registry and Review of the Literature.
Cerebellar Ataxia
Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1.
Cerebellar Ataxia
Late-onset autosomal recessive cerebellar ataxia and neuropathy with a novel splicing mutation in the ATM gene.
Cerebellar Diseases
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Cerebellar Diseases
A practical approach to avoiding iatrogenic Creutzfeldt-Jakob disease (CJD) from invasive instruments.
Cerebellar Diseases
Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.
Cerebellar Diseases
Role of magnetic resonance imaging, cerebrospinal fluid, and electroencephalogram in diagnosis of sporadic Creutzfeldt-Jakob disease.
Cerebral Amyloid Angiopathy
Cerebrovascular damage after midlife transient hypertension in non-transgenic and Alzheimer's disease rats.
Cerebral Amyloid Angiopathy
Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer's disease and cerebral amyloid angiopathy.
Cerebral Hemorrhage
c-Jun N-Terminal Kinase Pathway Inhibition in Intracerebral Hemorrhage.
Cerebral Hemorrhage
Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage.
Cerebral Hemorrhage
Discovery of Rho-kinase inhibitors by docking-based virtual screening.
Cerebral Hemorrhage
Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway.
Cerebral Hemorrhage
MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4/AKT Pathway in Intracerebral Hemorrhage Mice.
Cerebral Hemorrhage
Platelet-Derived Growth Factor Receptor-? Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice.
Cerebral Hemorrhage
RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats.
Cerebral Hemorrhage
RIP3 facilitates necroptosis through CaMKII and AIF after intracerebral hemorrhage in mice.
Cerebral Infarction
Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats.
Cerebral Infarction
Baicalin protects neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1
Cerebral Infarction
Butylphthalide inhibits nerve cell apoptosis in cerebral infarction rats via the JNK/p38 MAPK signaling pathway.
Cerebral Infarction
Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3?.
Cerebral Infarction
Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis.
Cerebral Infarction
Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation.
Cerebral Infarction
LncRNA SNHG1 inhibits neuronal apoptosis in cerebral infarction rats through PI3K/Akt signaling pathway.
Cerebral Infarction
MiR-29 inhibits neuronal apoptosis in rats with cerebral infarction through regulating Akt signaling pathway.
Cerebral Infarction
Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats.
Cerebral Infarction
Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.
Cerebral Infarction
Sevoflurane postconditioning attenuates cerebral ischemia-reperfusion injury via protein kinase B/nuclear factor-erythroid 2-related factor 2 pathway activation.
Cerebral Infarction
Sevoflurane postconditioning involves an up-regulation of HIF-1? and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia.
Cerebral Infarction
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Cerebral Infarction
[Effect of Schisandra chinensis lignans on neuronal apoptosis and p-AKT expression of rats in cerebral ischemia injury model].
Cerebrovascular Disorders
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Cerebrovascular Disorders
CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading.
Cervical Intraepithelial Neoplasia
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
cgmp-dependent protein kinase deficiency
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.
Chagas Disease
Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection.
Charcot-Marie-Tooth Disease
A stress-free strategy to correct point mutations in patient iPS cells.
Charcot-Marie-Tooth Disease
Combination of myotonic dystrophy and hereditary motor and sensory neuropathy.
Chemical and Drug Induced Liver Injury
Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling Pathway.
Cherubism
Point mutations of 3BP2 identified in human-inherited disease cherubism result in the loss of function.
Chickenpox
Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cells.
Chickenpox
Histone Deacetylase 1 and 2 are Phosphorylated at Novel Sites During Varicella Zoster Virus Infection.
Chickenpox
Phosphorylation of the Nuclear Form of Varicella Zoster Virus Immediate-Early Protein 63 by Casein Kinase II at Serine 186.
Cholangiocarcinoma
Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism.
Cholangiocarcinoma
Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
Cholangiocarcinoma
CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism.
Cholangiocarcinoma
Depletion of STYK1 inhibits intrahepatic cholangiocarcinoma development both in vitro and in vivo.
Cholangiocarcinoma
Immunohistochemical analysis of the mTOR pathway in intrahepatic cholangiocarcinoma.
Cholangiocarcinoma
Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.
Cholangiocarcinoma
JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction.
Cholangiocarcinoma
LRRK2 Is Associated with Recurrence-Free Survival in Intrahepatic Cholangiocarcinoma and Downregulation of LRRK2 Suppresses Tumor Progress In Vitro.
Cholangiocarcinoma
Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.
Cholangiocarcinoma
NOTCH1 regulates the viability of cholangiocarcinoma cells via 14-3-3 theta.
Cholangiocarcinoma
Overexpressions of CK2? and XIAP are Associated with Poor Prognosis of Patients with Cholangiocarcinoma.
Cholangiocarcinoma
Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells.
Cholangiocarcinoma
Preclinical In Vitro and In Vivo Evidence of an Antitumor Effect of CX-4945, a Casein Kinase II Inhibitor, in Cholangiocarcinoma.
Cholangiocarcinoma
PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma.
Cholangiocarcinoma
Raf kinase inhibitor protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix metalloproteinase 9 and upregulating tissue inhibitor of metalloproteinase 4 expression.
Cholangiocarcinoma
Role of stratifin (14-3-3 sigma) in adenocarcinoma of gallbladder: A novel prognostic biomarker.
Cholangiocarcinoma
Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities.
Cholangiocarcinoma
Suppression of 14-3-3? in cholangiocarcinoma cells inhibits proliferation through attenuated Akt activity, enhancing chemosensitivity to gemcitabine.
Cholangiocarcinoma
Suppression of PRKAR1A Expression Enhances Anti- proliferative and Apoptotic Effects of Protein Kinase Inhibitors and Chemotherapeutic Drugs on Cholangiocarcinoma Cells.
Cholangiocarcinoma
The antiproliferative effects of ataxia-telangiectasia mutated and ATM- and Rad3-related inhibitions and their enhancements with the cytotoxicity of DNA damaging agents in cholangiocarcinoma cells.
Cholangiocarcinoma
The clinicopathological and prognostic impact of 14-3-3 protein isoforms expression in human cholangiocarcinoma by immunohistochemistry.
Cholangiocarcinoma
The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.
Cholangiocarcinoma
The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas.
Cholangiocarcinoma
The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells.
Cholangiocarcinoma
The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.
Cholangiocarcinoma
Up-regulation of 14-3-3? expression in intrahepatic cholangiocarcinoma and its clinical implications.
Cholangiocarcinoma
Upregulation of 14-3-3 eta in chronic liver fluke infection is a potential diagnostic marker of cholangiocarcinoma.
Cholangiocarcinoma
Yin Yang 1-induced LINC00667 up-regulates pyruvate dehydrogenase kinase 1 to promote proliferation, migration and invasion of cholangiocarcinoma cells by sponging miR-200c-3p.
Cholangiocarcinoma
[Activated serine/threonine kinase AKT enhances the radioresistancy in human cholangiocarcinoma]
Cholangitis, Sclerosing
Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.
Cholecystitis
Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
Cholera
Action of cAMP on expression and release of adhesion molecules in human endothelial cells.
Cholera
Activation of G-protein-coupled receptor 30 increases T-type calcium currents in trigeminal ganglion neurons via the cholera toxin-sensitive protein kinase A pathway.
Cholera
Acute and chronic regulation of Na+/K+-ATPase transport activity in the RN22 Schwann cell line in response to stimulation of cyclic AMP production.
Cholera
Antiproliferative effect of brief exposure to cholera toxin in vascular smooth muscle cells: role of cAMP and protein kinase A.
Cholera
ATP-induced inhibition of Na+, K+, Cl- cotransport in Madin-Darby canine kidney cells: lack of involvement of known purinoceptor-coupled signaling pathways.
Cholera
Basic fibroblast growth factor stimulates repair of wounded hepatocyte monolayer: modulatory role of protein kinase A and extracellular matrix.
Cholera
Calcium-independent and cAMP-dependent modulation of soluble guanylyl cyclase activity by G protein-coupled receptors in pituitary cells.
Cholera
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Cholera
Characterization of parathyroid hormone/parathyroid hormone-related protein receptor and signaling in hypercalcemic Walker 256 tumor cells.
Cholera
Cholera toxin stimulates type II pneumocyte proliferation by a cyclic AMP-independent mechanism.
Cholera
Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c?Raf/MEK/ERK signaling pathway.
Cholera
Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A.
Cholera
Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol.
Cholera
Dual signalling by the adenosine A2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals.
Cholera
Gastric GATA-6 DNA-binding protein: proteolysis induced by cAMP.
Cholera
Glycogen synthase kinases-3beta controls differentiation of malignant glioma cells.
Cholera
Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene.
Cholera
Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line.
Cholera
Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.
Cholera
Inhibition of oxytocin-stimulated phosphoinositide turnover in rat myometrium by pertussis and cholera toxins may involve protein kinase A activation.
Cholera
Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP.
Cholera
Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
Cholera
Mechanisms mediating pituitary adenylate cyclase-activating polypeptide depolarization of rat sympathetic neurons.
Cholera
Molecular modulation of inward and outward apical transporters of L-dopa in LLC-PK(1) cells.
Cholera
Molecular Regulation of Human Placental Growth Factor (PlGF) Gene Expression in Placental Villi and Trophoblast Cells is Mediated via the Protein Kinase A Pathway.
Cholera
Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.
Cholera
Physiological evidence of integrin-antibody reactive proteins influencing the innate cellular immune responses of larval Galleria mellonella hemocytes.
Cholera
Pituitary adenylate cyclase-activating polypeptide and cyclic adenosine 3',5'-monophosphate stimulate the promoter activity of the rat gonadotropin-releasing hormone receptor gene via a bipartite response element in gonadotrope-derived cells.
Cholera
Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.
Cholera
Rat granulosa cell apolipoprotein E secretion. Regulation by cell cholesterol.
Cholera
Regulation of apical transporter of L-DOPA in human intestinal Caco-2 cells.
Cholera
Regulation of Bcl-2 protein expression in human neuroblastoma SH-SY5Y cells: positive and negative effects of protein kinases C and A, respectively.
Cholera
Regulation of extracellular calcium sensing in rat osteoclasts by femtomolar calcitonin concentrations.
Cholera
Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells.
Cholera
Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na(+)-K(+)-ATPase activity.
Cholera
Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells.
Cholera
Signaling pathway triggered by a short immunomodulating peptide on human monocytes.
Cholera
Stable guanosine 5'-triphosphate-analogues inhibit specific (+)-[3H]isradipine binding in rat hearts by a Ca(2+)-lowering, G protein-independent mechanism.
Cholera
Stepwise activation of the gonadotropic signal transduction pathway, and the ability of prostaglandin F2alpha to inhibit this activated pathway.
Cholera
Stimulation or endothelin-1 secretion by human breast cancer cells through protein kinase A activation: a possible novel paracrine loop involving breast fibroblast-derived prostaglandin E2.
Cholera
Suppression of voltage-dependent K+ currents in retinal bipolar cells by ascorbate.
Cholera
The cross-regulation of Gi-protein by cholera toxin involves a phosphorylation by protein kinase A.
Cholera
TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements.
Cholera
Two separate mechanisms for ligand-independent activation of the estrogen receptor.
Cholestasis
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver.
Cholesteatoma
Activation of the EGFR/Akt/NF-?B/cyclinD1 survival signaling pathway in human cholesteatoma epithelium.
Cholesteatoma
Autophagy Is Deficient and May be Negatively Regulated by SERPINB3 in Middle Ear Cholesteatoma.
Cholesteatoma
Expression of PTEN and phosphorylated Akt in human cholesteatoma epithelium.
Cholesteatoma
The role of EGFR/PI3K/Akt/cyclinD1 signaling pathway in acquired middle ear cholesteatoma.
Cholesteatoma
[Expression and significance of PTEN, P-ERK and P-AKT in the middle ear cholesteatoma].
Cholesteatoma, Middle Ear
[Expression and significance of PTEN, P-ERK and P-AKT in the middle ear cholesteatoma].
Chondroma
IDH1 immunohistochemistry reactivity and mosaic IDH1 or IDH2 somatic mutations in pediatric sporadic enchondroma and enchondromatosis.
Chondrosarcoma
CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK/ERK/NF-?B signaling pathway.
Chondrosarcoma
p38 kinase and c-Jun N-terminal kinase oppositely regulates tumor necrosis factor alpha-induced vascular cell adhesion molecule-1 expression and cell adhesion in chondrosarcoma cells.
Chondrosarcoma
Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells.
Chordoma
Inhibition Of Glycogen Synthase Kinase 3 Beta Suppresses The Growth And Survival Of Skull Base Chordoma Cells By Downregulating Brachyury Expression.
Chordoma
Overexpression of Raf-1 and ERK1/2 in sacral chordoma and association with tumor recurrence.
Chordoma
Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway.
Chordoma
The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.
Chorea
The nigrostriatal pathway in Creutzfeldt-Jakob disease.
Choriocarcinoma
Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line.
Choriocarcinoma
Cyclic AMP and phorbol esters interact synergistically to regulate expression of the chorionic gonadotropin genes.
Choriocarcinoma
Effect of 14-3-3 tau protein on differentiation in BeWo choriocarcinoma cells.
Choriocarcinoma
Human colony stimulating factor-1 receptor activates the C-raf-1 proto-oncogene kinase.
Choriocarcinoma
Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line.
Choriocarcinoma
Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma.
Choriocarcinoma
Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells.
Choriocarcinoma
Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells.
Chronic Periodontitis
ASC-dependent RIP2 Kinase Regulates Reduced PGE2 Production in Chronic Periodontitis.
Ciliary Motility Disorders
Mutation of serine/threonine protein kinase 36 (STK36) causes primary ciliary dyskinesia with a central pair defect.
Ciliopathies
Accumulation of the Raf-1 Kinase Inhibitory Protein (Rkip) Is Associated with Cep290-mediated Photoreceptor Degeneration in Ciliopathies.
Ciliopathies
Loss of Raf-1 kinase inhibitory protein delays early-onset severe retinal ciliopathy in Cep290rd16 mouse.
Ciliopathies
STK11 is required for the normal program of ciliated cell differentiation in airways.
Classical Lissencephalies and Subcortical Band Heterotopias
14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region.
Classical Lissencephalies and Subcortical Band Heterotopias
14-3-3? gene variants in a Japanese patient with left ventricular noncompaction and hypoplasia of the corpus callosum.
Classical Swine Fever
Viral strategies for triggering and manipulating mitophagy.
Cleft Palate
Alterations in protein kinase A signalling and cleft palate: a review.
Cleft Palate
Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.
Cleft Palate
Relevance of the palatal protein kinase A pathway to the pathogenesis of cleft palate by secalonic acid D in mice.
Cleft Palate
ROCK1 is associated with non-syndromic cleft palate.
Cleidocranial Dysplasia
GSK-3beta controls osteogenesis through regulating Runx2 activity.
Clonorchiasis
Identification and molecular characterization of a novel signaling molecule 14-3-3 epsilon in Clonorchis sinensis excretory/secretory products.
Clonorchiasis
The identification of antigenic proteins: 14-3-3 protein and propionyl-CoA carboxylase in Clonorchis sinensis.
Cockayne Syndrome
Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits.
Coffin-Lowry Syndrome
An Xp22.12 microduplication including RPS6KA3 identified in a family with variably affected intellectual and behavioral disabilities.
Coffin-Lowry Syndrome
Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome.
Coffin-Lowry Syndrome
Expression of the RSK2 gene during early human development.
Coffin-Lowry Syndrome
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.
Coffin-Lowry Syndrome
Intronic L1 insertion and F268S, novel mutations in RPS6KA3 (RSK2) causing Coffin-Lowry syndrome.
Coffin-Lowry Syndrome
P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
Coffin-Lowry Syndrome
Prenatal diagnosis in Coffin-Lowry syndrome demonstrates germinal mosaicism confirmed by mutation analysis.
Coffin-Lowry Syndrome
RSK2 enzymatic assay as a second level diagnostic tool in Coffin-Lowry syndrome.
Coffin-Lowry Syndrome
The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid.
Coffin-Lowry Syndrome
Transcriptome profile reveals AMPA receptor dysfunction in the hippocampus of the Rsk2-knockout mice, an animal model of Coffin-Lowry syndrome.
Coffin-Lowry Syndrome
Unreported RSK2 missense mutation in two male sibs with an unusually mild form of Coffin-Lowry syndrome.
Coinfection
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
Coinfection
Coinfection of insect cells with recombinant baculovirus expressing pp60v-src results in the activation of a serine-specific protein kinase pp90rsk.
Coinfection
Differential gel electrophoresis (DIGE) to quantitatively monitor early symbiosis- and pathogenesis-induced changes of the Medicago truncatula root proteome.
Coinfection
Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases.
Coinfection
Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation.
Coinfection
The role of annexin A1 in Candida albicans and Candida auris infections in murine neutrophils.
Colitis
Amelioration of dextran sulfate sodium-induced colitis by neuropeptide Y antisense oligodeoxynucleotide.
Colitis
An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.
Colitis
CARD3 Deficiency Protects Against Colitis Through Reduced Epithelial Cell Apoptosis.
Colitis
CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing.
Colitis
Cilostazol protects against acetic acid-induced colitis in rats: Possible role for cAMP/SIRT1 pathway.
Colitis
Claudin-2 pore causes leak that breaches the dam in intestinal inflammation.
Colitis
COX-1/PGE2/EP4 alleviates mucosal injury by upregulating ?-arr1-mediated Akt signaling in colitis.
Colitis
Effects of curcumin on apoptosis and oxidoinflammatory regulation in a rat model of acetic acid-induced colitis: the roles of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.
Colitis
ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction.
Colitis
EXPRESS: Phospholipase C gamma mediates endogenous brain-derived neurotrophic factor - regulated calcitonin gene-related peptide expression in colitis - induced visceral pain.
Colitis
Expression of A-kinase anchor protein 13 and Rho-associated coiled-coil containing protein kinase in restituted and regenerated mucosal epithelial cells following mucosal injury and colorectal cancer cells in mouse models.
Colitis
Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-?/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study.
Colitis
Lactobacillus casei protects dextran sodium sulfate- or rapamycin-induced colonic inflammation in the mouse.
Colitis
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Colitis
LRRK2 as a negative regulator of NFAT: implications for the pathogenesis of inflammatory bowel disease.
Colitis
PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis.
Colitis
Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.
Colitis
Protective effects of panax notoginseng saponin on dextran sulfate sodium-induced colitis in rats through phosphoinositide-3-kinase protein kinase B signaling pathway inhibition.
Colitis
Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis.
Colitis
Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice.
Colitis
Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta.
Colitis
RICK/RIP2 is a NOD2-independent nodal point of gut inflammation.
Colitis
RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases.
Colitis
Suppression of epithelial restitution using an inhibitor against Rho-associated coiled-coil containing protein kinase aggravates colitis through reduced epithelial expression of A-kinase anchor protein 13.
Colitis
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Colitis, Ulcerative
An Inhibitor of Casein Kinase 1?/? (PF670462) Prevents the Deterioration of Dextran Sodium Sulfate-induced Ulcerative Colitis Caused by UVB Eye Irradiation.
Colitis, Ulcerative
Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding.
Colitis, Ulcerative
Emerging views of mitophagy in immunity and autoimmune diseases.
Colitis, Ulcerative
Fusobacterium nucleatum facilitates ulcerative colitis through activating IL-17F signaling to NF-?B via the upregulation of CARD3 expression.
Colitis, Ulcerative
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.
Colitis, Ulcerative
How autophagy controls the intestinal epithelial barrier.
Colitis, Ulcerative
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Colitis, Ulcerative
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Colitis, Ulcerative
Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis.
Colitis, Ulcerative
TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patients with longstanding ulcerative colitis.
Colonic Neoplasms
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.
Colonic Neoplasms
5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.
Colonic Neoplasms
?-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths.
Colonic Neoplasms
A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma.
Colonic Neoplasms
A novel cancer testis antigen target A-kinase anchor protein (AKAP4) for the early diagnosis and immunotherapy of colon cancer.
Colonic Neoplasms
A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Colonic Neoplasms
A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells.
Colonic Neoplasms
A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.
Colonic Neoplasms
A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.
Colonic Neoplasms
Activation of PERK Contributes to Apoptosis and G2/M Arrest by Microtubule Disruptors in Human Colorectal Carcinoma Cells .
Colonic Neoplasms
Activity of glycogen synthase kinase-3beta is down-regulated during transient differentiation of human colon cancer HT-29 cells.
Colonic Neoplasms
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells.
Colonic Neoplasms
Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3.
Colonic Neoplasms
Association between the expression levels of TAZ, AXL and CTGF and clinicopathological parameters in patients with colon cancer.
Colonic Neoplasms
Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer.
Colonic Neoplasms
beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.
Colonic Neoplasms
Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer.
Colonic Neoplasms
Binding between ROCK1 and DCTN2 triggers diabetes?associated centrosome amplification in colon cancer cells.
Colonic Neoplasms
Ca(2+)/calmodulin-dependent protein kinase II promotes cell cycle progression by directly activating MEK1 and subsequently modulating p27 phosphorylation.
Colonic Neoplasms
Calotropin: A Cardenolide from Calotropis gigantea that Inhibits Wnt Signaling by Increasing Casein Kinase 1? in Colon Cancer Cells.
Colonic Neoplasms
CaMKII Mediates TGF?1-Induced Fibroblasts Activation and Its Cross Talk with Colon Cancer Cells.
Colonic Neoplasms
Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls.
Colonic Neoplasms
Cancer selective metallocenedicarboxylates of the fungal cytotoxin illudin M.
Colonic Neoplasms
Casein kinase 2 regulates the mRNA-destabilizing activity of tristetraprolin.
Colonic Neoplasms
Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex.
Colonic Neoplasms
Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line.
Colonic Neoplasms
Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819.
Colonic Neoplasms
Chemotherapy Regimen GOLF Induces Apoptosis in Colon Cancer Cells through Multi-Chaperone Complex Inactivation and Increased Raf-1 Ubiquitin-Dependent Degradation.
Colonic Neoplasms
Chibby suppresses growth of human SW480 colon adenocarcinoma cells through inhibition of beta-catenin signaling.
Colonic Neoplasms
Clearing the TRAIL for Cancer Therapy.
Colonic Neoplasms
Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro.
Colonic Neoplasms
Colchicine induces apoptosis in HT?29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways.
Colonic Neoplasms
Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability.
Colonic Neoplasms
Colon cancer-associated transcript-1 enhances glucose metabolism and colon cancer cell activity in a high-glucose environment in vitro and in vivo.
Colonic Neoplasms
Colon Cancer: A Clinician's Perspective in 2019.
Colonic Neoplasms
Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells.
Colonic Neoplasms
Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.
Colonic Neoplasms
Comparative mutational analysis of distal colon cancer with rectal cancer.
Colonic Neoplasms
Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.
Colonic Neoplasms
Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.
Colonic Neoplasms
Development and biological evaluation of a novel aurora A kinase inhibitor.
Colonic Neoplasms
Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and ?-catenin proteins.
Colonic Neoplasms
Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling.
Colonic Neoplasms
Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells.
Colonic Neoplasms
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.
Colonic Neoplasms
Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth.
Colonic Neoplasms
Effects of epidermal growth factor and mitogenic pathway inhibitors on rat colon cancer proliferation in vitro.
Colonic Neoplasms
Erlotinib inhibits colon cancer metastasis through inactivation of TrkB-dependent ERK signaling pathway.
Colonic Neoplasms
Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase.
Colonic Neoplasms
Experimental gene therapy of human colon cancer.
Colonic Neoplasms
Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues.
Colonic Neoplasms
Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane.
Colonic Neoplasms
Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
Colonic Neoplasms
Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity.
Colonic Neoplasms
Garcinone C suppresses colon tumorigenesis through the Gli1-dependent hedgehog signaling pathway.
Colonic Neoplasms
Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy.
Colonic Neoplasms
Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase.
Colonic Neoplasms
Growth-regulatory effect of gastrin on human colon cancer cell lines is determined by protein kinase a isoform content.
Colonic Neoplasms
GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma.
Colonic Neoplasms
GSK-3: An important kinase in colon and pancreatic cancers.
Colonic Neoplasms
Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway.
Colonic Neoplasms
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.
Colonic Neoplasms
HSP70 interacts with TRAF2 and differentially regulates TNFalpha signalling in human colon cancer cells.
Colonic Neoplasms
Hydroxychavicol, a polyphenol from Piper betle leaf extract, induces cell cycle arrest and apoptosis in TP53-resistant HT-29 colon cancer cells.
Colonic Neoplasms
Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1.
Colonic Neoplasms
IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas.
Colonic Neoplasms
Immuno-Affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance.
Colonic Neoplasms
In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.
Colonic Neoplasms
Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity.
Colonic Neoplasms
Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer.
Colonic Neoplasms
Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents.
Colonic Neoplasms
Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells.
Colonic Neoplasms
Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues.
Colonic Neoplasms
Intratumoral heterogeneity of CSNK1G3 mutations, a casein kinase 1, in colon cancers.
Colonic Neoplasms
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Colonic Neoplasms
Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma.
Colonic Neoplasms
Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells.
Colonic Neoplasms
Kinase signaling pathways as targets for intervention in pancreatic cancer.
Colonic Neoplasms
Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway.
Colonic Neoplasms
Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling.
Colonic Neoplasms
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Colonic Neoplasms
Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer.
Colonic Neoplasms
Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation.
Colonic Neoplasms
Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648.
Colonic Neoplasms
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer.
Colonic Neoplasms
MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells.
Colonic Neoplasms
MicroRNA-27a Promotes the Proliferation and Invasiveness of Colon Cancer Cells by Targeting SFRP1 through the Wnt/?-Catenin Signaling Pathway.
Colonic Neoplasms
MiR-566 mediates cell migration and invasion in colon cancer cells by direct targeting of PSKH1.
Colonic Neoplasms
Mirk regulates the exit of colon cancer cells from quiescence.
Colonic Neoplasms
Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells.
Colonic Neoplasms
MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth.
Colonic Neoplasms
Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example.
Colonic Neoplasms
Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection.
Colonic Neoplasms
Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta.
Colonic Neoplasms
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA.
Colonic Neoplasms
Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.
Colonic Neoplasms
p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells.
Colonic Neoplasms
Pharmacological Inhibition of Casein Kinase 2 Enhances the Effectiveness of PI3K Inhibition in Colon Cancer Cells.
Colonic Neoplasms
Phenotypic Profiling of Raf Inhibitors and Mitochondrial Toxicity in 3D Tissue Using Biodynamic Imaging.
Colonic Neoplasms
Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.
Colonic Neoplasms
Polymerase synthesis and potential interference of a small-interfering RNA targeting hPim-2.
Colonic Neoplasms
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Colonic Neoplasms
Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells.
Colonic Neoplasms
Protein kinase A regulatory subunits in colon cancer.
Colonic Neoplasms
Protein kinase D1 attenuates tumorigenesis in colon cancer by modulating ?-catenin/T cell factor activity.
Colonic Neoplasms
Proteomic analysis of differentially expressed proteins in peripheral cholangiocarcinoma.
Colonic Neoplasms
Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.
Colonic Neoplasms
PRP4 Kinase Domain Loss Nullifies Drug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells.
Colonic Neoplasms
Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice.
Colonic Neoplasms
RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Colonic Neoplasms
Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.
Colonic Neoplasms
Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial? mesenchymal transition via the AKT/GSK?3?/Snail signaling pathway.
Colonic Neoplasms
Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown.
Colonic Neoplasms
RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line LoVo.
Colonic Neoplasms
RNA sequencing identified novel target genes for Adansonia digitata in breast and colon cancer cells.
Colonic Neoplasms
Selective growth inhibition by glycogen synthase kinase-3 inhibitors in tumorigenic HeLa hybrid cells is mediated through NF-?B-dependent GLUT3 expression.
Colonic Neoplasms
Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D.
Colonic Neoplasms
Serine/threonine kinase 31 promotes PDCD5-mediated apoptosis in p53-dependent human colon cancer cells.
Colonic Neoplasms
Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3beta activity and increases levels of both membrane-bound and Apc/axin/GSK-3beta complex-associated pools of beta-catenin.
Colonic Neoplasms
Stability of phosphoprotein as a biological marker of tumor signaling.
Colonic Neoplasms
STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.
Colonic Neoplasms
Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone.
Colonic Neoplasms
Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy.
Colonic Neoplasms
The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines.
Colonic Neoplasms
The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta.
Colonic Neoplasms
The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling.
Colonic Neoplasms
Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function.
Colonic Neoplasms
Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon.
Colonic Neoplasms
Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation.
Colonic Neoplasms
Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.
Colonic Neoplasms
TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor.
Colonic Neoplasms
Ubiquitin Ligase, Fbw7, Targets CDX2 for Degradation via Two Phosphodegron Motifs in a GSK3beta-dependent Manner.
Colonic Neoplasms
Understanding h-prune biology in the fight against cancer.
Colonic Neoplasms
Up-regulation of CIT promotes the growth of colon cancer cells.
Colonic Neoplasms
Upregulation of miR-542-3p inhibits the growth and invasion of human colon cancer cells through PI3K/AKT/survivin signaling.
Colonic Neoplasms
Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells.
Colonic Neoplasms
Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent.
Colonic Neoplasms
[Study on the Effect of Overexpression of miR-18a on Cellular Proliferation and Migration by Targeting ATM in Human Colorectal Cancer Cells].
Colonic Neoplasms
[The anti-tumor activity and molecular mechanisms of an Aurora kinase inhibitor ZLJ213 in suppressing colon cancer growth].
Colorectal Neoplasms
15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity.
Colorectal Neoplasms
3'-hydroxy-4'-methoxy-?-methyl-?-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction.
Colorectal Neoplasms
A Meta-Regression Method for Studying Etiological Heterogeneity Across Disease Subtypes Classified by Multiple Biomarkers.
Colorectal Neoplasms
A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer.
Colorectal Neoplasms
A novel mechanism of keratin cytoskeleton organization through casein kinase I? and FAM83H in colorectal cancer.
Colorectal Neoplasms
A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.
Colorectal Neoplasms
A-Kinase Anchoring Proteins 10 Expression in Relation to 2073A/G Polymorphism and Tumor Progression in Patients with Colorectal Cancer.
Colorectal Neoplasms
Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia.
Colorectal Neoplasms
Activation of AKT signaling promotes epithelial-mesenchymal transition and tumor growth in colorectal cancer cells.
Colorectal Neoplasms
Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells.
Colorectal Neoplasms
Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.
Colorectal Neoplasms
Altered cardiac muscle mTOR regulation during the progression of cancer cachexia in the ApcMin/+ mouse.
Colorectal Neoplasms
Analysis of RIN1 gene expression in colorectal cancer.
Colorectal Neoplasms
Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.
Colorectal Neoplasms
Apical membrane localization of glycogen synthase kinase 3beta protein in normal colon epithelium and aberrant distribution in colorectal cancer.
Colorectal Neoplasms
Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-?e8 isoform.
Colorectal Neoplasms
Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer.
Colorectal Neoplasms
ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer.
Colorectal Neoplasms
Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers.
Colorectal Neoplasms
Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53.
Colorectal Neoplasms
Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.
Colorectal Neoplasms
AZ32 Reverses ABCG2-Mediated Multidrug Resistance in Colorectal Cancer.
Colorectal Neoplasms
Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.
Colorectal Neoplasms
BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Colorectal Neoplasms
BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma.
Colorectal Neoplasms
Case-control, kin-cohort and meta-analyses provide no support for STK15 F31I as a low penetrance colorectal cancer allele.
Colorectal Neoplasms
Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON.
Colorectal Neoplasms
Casein Kinase 2? Enhances 5-Fluorouracil Resistance in Colorectal Cancer Cells by Inhibiting Endoplasmic Reticulum Stress.
Colorectal Neoplasms
Casein Kinase-1-Alpha Inhibitor (D4476) Sensitizes Microsatellite Instable Colorectal Cancer Cells to 5-Fluorouracil via Authophagy Flux Inhibition.
Colorectal Neoplasms
Cell surface integrin ?5ß1 clustering negatively regulates receptor tyrosine kinase signaling in colorectal cancer cells via glycogen synthase kinase 3.
Colorectal Neoplasms
Characterization of casein kinase II in human colonic carcinomas after heterotransplantation into nude mice.
Colorectal Neoplasms
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.
Colorectal Neoplasms
CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Colorectal Neoplasms
Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
Colorectal Neoplasms
Close localization of DAP-kinase positive tumour-associated macrophages and apoptotic colorectal cancer cells.
Colorectal Neoplasms
Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis.
Colorectal Neoplasms
Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.
Colorectal Neoplasms
Combined Short-Term Glucose Starvation and Chemotherapy in 3D Colorectal Cancer Cell Culture Decreases 14-3-3 Family Protein Expression and Phenotypic Response to Therapy.
Colorectal Neoplasms
Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.
Colorectal Neoplasms
Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.
Colorectal Neoplasms
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Colorectal Neoplasms
Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression.
Colorectal Neoplasms
CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer.
Colorectal Neoplasms
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Colorectal Neoplasms
Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.
Colorectal Neoplasms
Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay.
Colorectal Neoplasms
Development of small-molecule therapeutics and strategies for targeting RAF kinase in BRAF-mutant colorectal cancer.
Colorectal Neoplasms
Diagnostic relevance of overexpressed serine threonine tyrosine kinase/novel oncogene with kinase domain (STYK1/ NOK) mRNA in colorectal cancer.
Colorectal Neoplasms
Differences in symptom occurrence, severity, and distress ratings between patients with gastrointestinal cancers who received chemotherapy alone or chemotherapy with targeted therapy.
Colorectal Neoplasms
DNA-PKcs interference sensitizes colorectal cancer cells to a mTOR kinase inhibitor WAY-600.
Colorectal Neoplasms
Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.
Colorectal Neoplasms
Effect of casein kinase 1? inhibition on autophagy flux and the AKT/phospho-?-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line.
Colorectal Neoplasms
Effect of Raf kinase inhibitor protein expression on malignant biological behavior and progression of colorectal cancer.
Colorectal Neoplasms
Effect of RSK4 on biological characteristics of colorectal cancer.
Colorectal Neoplasms
Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells.
Colorectal Neoplasms
Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer.
Colorectal Neoplasms
Emodin suppresses growth and invasion of colorectal cancer cells by inhibiting VEGFR2.
Colorectal Neoplasms
Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells.
Colorectal Neoplasms
Evi-1 Influence on Clinical Progress of Colorectal Cancer Patients.
Colorectal Neoplasms
Exosomal miR-1229 derived from colorectal cancer cells promotes angiogenesis by targeting HIPK2.
Colorectal Neoplasms
Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer.
Colorectal Neoplasms
Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue.
Colorectal Neoplasms
Expression of A-kinase anchor protein 13 and Rho-associated coiled-coil containing protein kinase in restituted and regenerated mucosal epithelial cells following mucosal injury and colorectal cancer cells in mouse models.
Colorectal Neoplasms
Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues.
Colorectal Neoplasms
Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression.
Colorectal Neoplasms
Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases.
Colorectal Neoplasms
Expression of phosphorylated extracellular signal-regulated kinase at the invasive front of hepatic colorectal metastasis.
Colorectal Neoplasms
Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability.
Colorectal Neoplasms
Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
Colorectal Neoplasms
Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression.
Colorectal Neoplasms
Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.
Colorectal Neoplasms
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Colorectal Neoplasms
Genetic Variations in STK11, PRKAA1, and TSC1 Associated with Prognosis for Patients with Colorectal Cancer.
Colorectal Neoplasms
Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer.
Colorectal Neoplasms
Germline Genetic Variants in the Wnt/?-Catenin Pathway as Predictors of Colorectal Cancer Risk.
Colorectal Neoplasms
Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase.
Colorectal Neoplasms
GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.
Colorectal Neoplasms
High frequency of DAP-kinase gene promoter methylation in colorectal cancer specimens and its identification in serum.
Colorectal Neoplasms
HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer.
Colorectal Neoplasms
HIPK2 phosphorylates HDAC3 for NF-?B acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.
Colorectal Neoplasms
HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation.
Colorectal Neoplasms
Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
Colorectal Neoplasms
How autophagy controls the intestinal epithelial barrier.
Colorectal Neoplasms
Hunk/Mak-v is a negative regulator of intestinal cell proliferation.
Colorectal Neoplasms
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay.
Colorectal Neoplasms
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3?.
Colorectal Neoplasms
Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway.
Colorectal Neoplasms
IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells.
Colorectal Neoplasms
IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF-1 degradation by miR-195.
Colorectal Neoplasms
Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy.
Colorectal Neoplasms
Increased expression of beta-catenin, phosphorylated glycogen synthase kinase 3beta, cyclin D1, and c-myc in laterally spreading colorectal tumors.
Colorectal Neoplasms
Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related (ATR) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer.
Colorectal Neoplasms
Interleukin-17 promotes the development of cisplatin resistance in colorectal cancer.
Colorectal Neoplasms
Intramedullary solitary fibrous tumor of dorsal spinal cord.
Colorectal Neoplasms
Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.
Colorectal Neoplasms
KNOCKDOWN OF CASEIN KINASE 1e INHIBITS CELL PROLIFERATION AND INVASION OF COLORECTAL CANCER CELLS VIA INHIBITION OF THE Wnt/?-CATENIN SIGNALING.
Colorectal Neoplasms
Knockin of mutant PIK3CA activates multiple oncogenic pathways.
Colorectal Neoplasms
KRAS and BRAF mutations in serum exosomes from patients with colorectal cancer in a Chinese population.
Colorectal Neoplasms
Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer.
Colorectal Neoplasms
Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer.
Colorectal Neoplasms
Matrix-Bound PAI-1 Supports Cell Blebbing via RhoA/ROCK1 Signaling.
Colorectal Neoplasms
Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells.
Colorectal Neoplasms
Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation.
Colorectal Neoplasms
MicroRNA-124 (MiR-124) Inhibits Cell Proliferation, Metastasis and Invasion in Colorectal Cancer by Downregulating Rho-Associated Protein Kinase 1(ROCK1).
Colorectal Neoplasms
MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer.
Colorectal Neoplasms
MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer.
Colorectal Neoplasms
MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase.
Colorectal Neoplasms
MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1.
Colorectal Neoplasms
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Colorectal Neoplasms
Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer.
Colorectal Neoplasms
Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma.
Colorectal Neoplasms
New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.
Colorectal Neoplasms
Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression.
Colorectal Neoplasms
Nondysplastic Ulcerative Colitis Has High Levels of the Homologous Recombination Repair Protein NUCKS1 and Low Levels of the DNA Damage Marker Gamma-H2AX.
Colorectal Neoplasms
Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon.
Colorectal Neoplasms
Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors.
Colorectal Neoplasms
NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3.
Colorectal Neoplasms
Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition.
Colorectal Neoplasms
Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/?-Catenin Signaling.
Colorectal Neoplasms
Optimization of the diagnosis of inherited colorectal cancer using NGS and capture of exonic and intronic sequences of panel genes.
Colorectal Neoplasms
Overexpression of integrin-linked kinase (ILK) is associated with tumor progression and an unfavorable prognosis in patients with colorectal cancer.
Colorectal Neoplasms
Overexpression of integrin-linked kinase (ILK) promotes migration and invasion of colorectal cancer cells by inducing epithelial-mesenchymal transition via NF-?B signaling.
Colorectal Neoplasms
Overexpression of nuclear protein kinase CK2 ? catalytic subunit (CK2?) as a poor prognosticator in human colorectal cancer.
Colorectal Neoplasms
p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells.
Colorectal Neoplasms
PAK1 promotes intestinal tumor initiation.
Colorectal Neoplasms
PB-10, a thiazolo[4,5-d] pyrimidine derivative, targets p21-activated kinase 4 in human colorectal cancer cells.
Colorectal Neoplasms
Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells.
Colorectal Neoplasms
Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.
Colorectal Neoplasms
Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells.
Colorectal Neoplasms
Phosphorylation of p70 Ribosomal Protein S6 Kinase ?-1 is an Independent Prognostic Parameter in Metastatic Colorectal Cancer.
Colorectal Neoplasms
Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer.
Colorectal Neoplasms
Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.
Colorectal Neoplasms
PI3K/Akt and GSK-3beta prevents in a differential fashion the malignant phenotype of colorectal cancer cells.
Colorectal Neoplasms
PIK3CA mutation is predictive of poor survival in patients with colorectal cancer.
Colorectal Neoplasms
Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors.
Colorectal Neoplasms
Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma.
Colorectal Neoplasms
Possible Gender-Related Modulation by the ROCK1 Gene in Colorectal Cancer Susceptibility.
Colorectal Neoplasms
Preliminary Study on the Identification of BRAFV600E Mutation in Colorectal Cancer by Near-Infrared Spectroscopy.
Colorectal Neoplasms
Prevalence and prognostic relevance of BrafV600E mutation in colorectal carcinomas from Kashmir (North India) valley.
Colorectal Neoplasms
Probiotic Lactobacillus salivarius Ren prevent dimethylhydrazine-induced colorectal cancer through protein kinase B inhibition.
Colorectal Neoplasms
Protein kinase A (PK-A) regulatory subunit expression in colorectal cancer and related mucosa.
Colorectal Neoplasms
Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer.
Colorectal Neoplasms
Protein Kinase D as a Potential Chemotherapeutic Target for Colorectal Cancer.
Colorectal Neoplasms
PRP4 Kinase Domain Loss Nullifies Drug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells.
Colorectal Neoplasms
Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4? in Colorectal Cancer Cells.
Colorectal Neoplasms
Rab23 contributes to the progression of colorectal cancer via protein kinase B and extracellular signal-regulated kinase signaling pathways.
Colorectal Neoplasms
Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients.
Colorectal Neoplasms
Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients.
Colorectal Neoplasms
Raf-1 kinase, epidermal growth factor receptors, and mutant Ras proteins in colonic carcinomas.
Colorectal Neoplasms
Receptor-Interacting Serine/Threonine-Protein Kinase-2 as a Potential Prognostic Factor in Colorectal Cancer.
Colorectal Neoplasms
Reduced Raf-1 kinase inhibitor protein expression predicts less favorable outcomes in patients with hepatic colorectal metastasis.
Colorectal Neoplasms
Reduction of beta-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated beta-catenin.
Colorectal Neoplasms
Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3? (GSK-3?) and microtubule-associated protein 1B.
Colorectal Neoplasms
Role of serine/threonine kinase 33 methylation in colorectal cancer and its clinical significance.
Colorectal Neoplasms
Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer.
Colorectal Neoplasms
Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
Colorectal Neoplasms
Silencing NOB1 Can Affect Cell Proliferation and Apoptosis Via the C-Jun N-Terminal Kinase Pathway in Colorectal Cancer.
Colorectal Neoplasms
Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/?-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.
Colorectal Neoplasms
STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.
Colorectal Neoplasms
STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1?/VEGF signaling pathway.
Colorectal Neoplasms
Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers.
Colorectal Neoplasms
Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer.
Colorectal Neoplasms
Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library.
Colorectal Neoplasms
Targeting BRAF in metastatic colorectal cancer: Maximizing molecular approaches.
Colorectal Neoplasms
Targeting cytosolic phospholipase A2 ? in colorectal cancer cells inhibits constitutively activated protein kinase B (AKT) and cell proliferation.
Colorectal Neoplasms
Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
Colorectal Neoplasms
TGF? and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells.
Colorectal Neoplasms
The clinical implication of 14-3-3 sigma expression in primary gastrointestinal malignancy.
Colorectal Neoplasms
The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells.
Colorectal Neoplasms
The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer.
Colorectal Neoplasms
The Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 and the risk of colorectal cancer.
Colorectal Neoplasms
The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
Colorectal Neoplasms
The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer.
Colorectal Neoplasms
The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas.
Colorectal Neoplasms
The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines.
Colorectal Neoplasms
The Role of p53 Signaling in Colorectal Cancer.
Colorectal Neoplasms
The roles of microbial products in the development of colorectal cancer: a review.
Colorectal Neoplasms
Treatment options in BRAF-mutant metastatic colorectal cancer.
Colorectal Neoplasms
TRIM27 functions as an oncogene by activating epithelial-mesenchymal transition and p-AKT in colorectal cancer.
Colorectal Neoplasms
Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.
Colorectal Neoplasms
Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer.
Colorectal Neoplasms
[Clinicopathological significance of expression and amplification of P21-activated kinase 1 gene in colorectal carcinoma]
Colorectal Neoplasms
[Clinicopathological significance of expressions of DNA dependent protein kinase catalytic subunit and P16 in colorectal carcinoma]
Colorectal Neoplasms
[Correlation of casein kinase 2? overexpression to the metastatic ability of colorectal cancer cells in vitro].
Colorectal Neoplasms
[Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome].
Colorectal Neoplasms
[Effect of p21-activated kinase-1 on the invasiveness of colorectal carcinoma cells in vitro]
Colorectal Neoplasms
[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer]
Colorectal Neoplasms, Hereditary Nonpolyposis
Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.
Colorectal Neoplasms, Hereditary Nonpolyposis
Genetic testing by cancer site: stomach.
Colorectal Neoplasms, Hereditary Nonpolyposis
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Colorectal Neoplasms, Hereditary Nonpolyposis
Outcomes of endoscopic ultrasound as a one-off pancreatic cancer screening tool for 122 high- and moderate-risk patients.
Colorectal Neoplasms, Hereditary Nonpolyposis
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Colorectal Neoplasms, Hereditary Nonpolyposis
Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA.
Colorectal Neoplasms, Hereditary Nonpolyposis
Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes.
Colorectal Neoplasms, Hereditary Nonpolyposis
The influence of STK11 mutation on acquired resistance to immunotherapy in advanced non-small cell lung cancer with Lynch syndrome: a case report and literature review.
Colorectal Neoplasms, Hereditary Nonpolyposis
Time to incorporate germline multigene panel testing into breast and ovarian cancer patient care.
Coma
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma.
Coma
Persistent translocation and inhibition of Ca2+/calmodulin-dependent protein kinase II in the crude synaptosomal fraction of the vulnerable hippocampus following hypoglycemia.
Common Variable Immunodeficiency
Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency.
Communicable Diseases
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.
Communicable Diseases
Glycogen synthase 3 (GSK-3) regulation of PD-1 expression and and its therapeutic implications.
Communicable Diseases
LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.
Communicable Diseases
Regulatory Role of GSK-3 ? on NF- ? B, Nitric Oxide, and TNF- ? in Group A Streptococcal Infection.
Communicable Diseases
The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases.
Communicable Diseases
Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice.
Communicable Diseases
Transcriptomic and Network Analysis Highlight the Association of Diabetes at Different Stages of Alzheimer's Disease.
Confusion
Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies.
Congenital Abnormalities
miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1.
Congenital Disorders of Glycosylation
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Congenital Hyperinsulinism
Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Contracture
CaMKII mediates myocardial ischemia/reperfusion injury?induced contracture in isolated rat heart.
Contracture
Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae.
Corneal Injuries
Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization.
Corneal Injuries
The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea.
Coronary Artery Disease
Association between a gene variant near ataxia telangiectasia mutated and coronary artery disease in men.
Coronary Artery Disease
Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China.
Coronary Artery Disease
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Coronary Artery Disease
Delayed re-endothelialization with rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3beta inhibitor.
Coronary Artery Disease
Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease.
Coronary Artery Disease
GSK-3beta, a therapeutic target for cardiomyocyte protection.
Coronary Artery Disease
Optimisation of methods for quantifying plasma mRNA levels from genes responsible for coronary artery plaque development and destabilization.
Coronary Disease
Klotho overexpression suppresses apoptosis by regulating the Hsp70/Akt/Bad pathway in H9c2(2-1) cells.
Coronary Occlusion
Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion.
Coronary Stenosis
Functional polymorphism rs189037 in the promoter region of ATM gene is associated with angiographically characterized coronary stenosis.
Coronavirus Infections
Coronavirus interactions with the cellular autophagy machinery.
Coronavirus Infections
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection.
Coronavirus Infections
Lithium and Therapeutic Targeting of GSK-3.
Corticobasal Degeneration
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Corticobasal Degeneration
Corticobasal syndrome and primary progressive aphasia as manifestations of lrrk2 gene mutations.
Corticobasal Degeneration
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.
Corticobasal Degeneration
LRRK2 and neurodegeneration.
Corticobasal Degeneration
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Corticobasal Degeneration
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration.
COVID-19
Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection.
COVID-19
Computational assessment of saikosaponins as adjuvant treatment for COVID-19: molecular docking, dynamics, and network pharmacology analysis.
COVID-19
Coronavirus interactions with the cellular autophagy machinery.
COVID-19
Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins.
COVID-19
Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
COVID-19
Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition.
COVID-19
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Craniocerebral Trauma
Age at Onset of Parkinson's Disease Among Ashkenazi Jewish Patients: Contribution of Environmental Factors, LRRK2 p.G2019S and GBA p.N370S Mutations.
Craniocerebral Trauma
Glycogen synthase kinase 3: an emerging therapeutic target.
Creutzfeldt-Jakob Syndrome
14-3-3 cerebrospinal fluid protein and Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
14-3-3 CSF levels in sporadic Creutzfeldt-Jakob disease differ across molecular subtypes.
Creutzfeldt-Jakob Syndrome
14-3-3 in the cerebrospinal fluid of patients with variant and sporadic Creutzfeldt-Jakob disease measured using capture assay able to detect low levels of 14-3-3 protein.
Creutzfeldt-Jakob Syndrome
14-3-3 protein cerebrospinal fluid detection in human growth hormone-treated Creutzfeldt-Jakob disease patients.
Creutzfeldt-Jakob Syndrome
14-3-3 protein in the CSF of patients with rapidly progressive dementia.
Creutzfeldt-Jakob Syndrome
14-3-3 Protein isoforms and atypical patterns of the 14-3-3 assay in the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
14-3-3 protein levels and isoform patterns in the cerebrospinal fluid of Creutzfeldt-Jakob disease patients in the progressive and terminal stages.
Creutzfeldt-Jakob Syndrome
14-3-3 protein, neuron-specific enolase, and S-100 protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
14-3-3 protein, total tau and phosphorylated tau in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease and neurodegenerative disease in Japan.
Creutzfeldt-Jakob Syndrome
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Creutzfeldt-Jakob Syndrome
14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients.
Creutzfeldt-Jakob Syndrome
14-3-3 {gamma}-isoform detection distinguishes sporadic Creutzfeldt-Jakob disease from other dementias.
Creutzfeldt-Jakob Syndrome
A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
A novel binding assay for detection of 14-3-3 protein in cerebrospinal fluid from Creutzfeldt-Jakob patients.
Creutzfeldt-Jakob Syndrome
A polymorphism in the YWHAH gene encoding 14-3-3 eta that is not associated with sporadic Creutzfeldt-Jakob disease (CJD).
Creutzfeldt-Jakob Syndrome
A systematic review comparing the diagnostic value of 14-3-3 protein in the cerebrospinal fluid, RT-QuIC and RT-QuIC on nasal brushing in sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009.
Creutzfeldt-Jakob Syndrome
Advances in diagnosing Creutzfeldt-Jakob disease with MRI and CSF 14-3-3 protein analysis.
Creutzfeldt-Jakob Syndrome
Alternative application of Tau protein in Creutzfeldt-Jakob disease diagnosis: Improvement for weakly positive 14-3-3 protein in the laboratory.
Creutzfeldt-Jakob Syndrome
An enzyme-linked immunosorbent assay to quantify 14-3-3 proteins in the cerebrospinal fluid of suspected Creutzfeldt-Jakob disease patients.
Creutzfeldt-Jakob Syndrome
An unusual case of sporadic Creutzfeldt-Jakob disease (CJD).
Creutzfeldt-Jakob Syndrome
Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Applicability of long-term electroencephalography in pre-mortem diagnosis of Creutzfeldt-Jakob disease: A case report.
Creutzfeldt-Jakob Syndrome
Autopsy-proven Creutzfeldt-Jakob disease in a patient with a negative 14-3-3 assay and nonspecific EEG and MRI.
Creutzfeldt-Jakob Syndrome
Biochemical investigations in patients with dementia.
Creutzfeldt-Jakob Syndrome
Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid 14-3-3 protein: variability of sporadic Creutzfeldt-Jakob disease, laboratory standards, and quantitation.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid biomarkers in clinically isolated syndromes and multiple sclerosis.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies.
Creutzfeldt-Jakob Syndrome
Cerebrospinal Fluid Biomarkers in the Diagnosis of Creutzfeldt-Jakob Disease in Slovak Patients: over 10-Year Period Review.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid brain-derived proteins in the diagnosis of Alzheimer's disease and Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Cerebrospinal Fluid Levels of 14-3-3 Gamma: What Does It Tell Us About Sporadic Creutzfeldt-Jakob Disease?
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid markers in Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid non-phosphorylated tau in the differential diagnosis of Creutzfeldt-Jakob disease: a comparative prospective study with 14-3-3.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Characteristics of Korean patients with suspected Creutzfeldt-Jakob disease with 14-3-3 protein in cerebrospinal fluid: Preliminary study of the Korean Creutzfeldt-Jakob disease active surveillance program.
Creutzfeldt-Jakob Syndrome
Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis.
Creutzfeldt-Jakob Syndrome
Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type 2.
Creutzfeldt-Jakob Syndrome
Comatose within 6 weeks, but still alive after 3 years, Creutzfeldt-Jakob disease with unusual progression.
Creutzfeldt-Jakob Syndrome
Conduction aphasia as an initial symptom in a patient with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob disease mimicking autoimmune encephalitis with CASPR2 antibodies.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob Disease Presenting as Posterior Reversible Encephalopathy Syndrome.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob disease with initial right hemiparesis masquerading as a stroke.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob disease: diagnostic utility of 14-3-3 protein immunodetection in cerebrospinal fluid.
Creutzfeldt-Jakob Syndrome
CSF nonphosphorylated Tau as a biomarker for the discrimination of AD from CJD.
Creutzfeldt-Jakob Syndrome
CSF Tau proteins reduce misdiagnosis of sporadic Creutzfeldt-Jakob disease suspected cases with inconclusive 14-3-3 result.
Creutzfeldt-Jakob Syndrome
CSF Tau supplements 14-3-3 protein detection for sporadic Creutzfeldt-Jakob disease diagnosis while transitioning to next generation diagnostics.
Creutzfeldt-Jakob Syndrome
Desmoplakin as a Potential Candidate for Cerebrospinal Fluid Marker to Rule Out 14-3-3 False Positive Rates in Sporadic Creutzfeldt-Jakob Disease Differential Diagnosis.
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders.
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3 protein in the CSF of genetic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3zeta in cerebrospinal fluid following experimentally evoked seizures.
Creutzfeldt-Jakob Syndrome
Detection of CSF 14-3-3 Protein in Sporadic Creutzfeldt-Jakob Disease Patients Using a New Automated Capillary Western Assay.
Creutzfeldt-Jakob Syndrome
Determination of 14-3-3 protein levels in cerebrospinal fluid from Creutzfeldt-Jakob patients by a highly sensitive capture assay.
Creutzfeldt-Jakob Syndrome
Development of a dot blot assay with antibodies to recombinant "core" 14-3-3 protein: Evaluation of its usefulness in diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Diagnosis of Creutzfeldt-Jakob disease: effect of clinical criteria on incidence estimates. Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Discrepancies in the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Drug-induced Creutzfeldt-Jakob disease-like syndrome: early CSF analysis as useful tool for differential diagnosis.
Creutzfeldt-Jakob Syndrome
Elevated total tau/phospho-tau ratio in autopsy-proven Creutzfeldt-Jakob disease with negative 14-3-3 test results.
Creutzfeldt-Jakob Syndrome
Enhanced expression of 14-3-3 proteins in reactive astrocytes in Creutzfeldt-Jakob disease brains.
Creutzfeldt-Jakob Syndrome
ERK2 is increased in cerebrospinal fluid of Creutzfeldt-Jakob disease patients.
Creutzfeldt-Jakob Syndrome
Establishment of a standard 14-3-3 protein assay of cerebrospinal fluid as a diagnostic tool for Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology.
Creutzfeldt-Jakob Syndrome
Extreme loss of neurons in sporadic Creutzfeldt-Jakob disease with 14-3-3 protein in cerebrospinal fluid.
Creutzfeldt-Jakob Syndrome
Hashimoto's encephalitis as a differential diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
How many biomarkers to discriminate neurodegenerative dementia?
Creutzfeldt-Jakob Syndrome
How to improve the clinical diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain.
Creutzfeldt-Jakob Syndrome
Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD.
Creutzfeldt-Jakob Syndrome
Increased 14-3-3? and ? protein isoform expressions in parasitic eosinophilic meningitis caused by Angiostrongylus cantonensis infection in mice.
Creutzfeldt-Jakob Syndrome
Increased detection of 14-3-3 protein in cerebrospinal fluid in Sporadic Creutzfeldt-Jakob Disease during the disease course.
Creutzfeldt-Jakob Syndrome
Increased levels of epsilon and gamma isoforms of 14-3-3 proteins in cerebrospinal fluid in patients with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Infection of Prions and Treatment of PrP106-126 Alter the Endogenous Status of Protein 14-3-3 and Trigger the Mitochondrial Apoptosis Possibly via Activating Bax Pathway.
Creutzfeldt-Jakob Syndrome
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Lack of association between 14-3-3 beta gene (YWHAB) polymorphisms and sporadic Creutzfeldt-Jakob disease (CJD).
Creutzfeldt-Jakob Syndrome
Magnetic resonance spectroscopy and measurement of tau epitopes of autopsy proven sporadic Creutzfeldt-Jakob disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 immunoblot.
Creutzfeldt-Jakob Syndrome
Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease: a study on inter-observer agreement.
Creutzfeldt-Jakob Syndrome
Normalization of 14-3-3 in CJD.
Creutzfeldt-Jakob Syndrome
Novel prion protein gene mutation presenting with subacute PSP-like syndrome.
Creutzfeldt-Jakob Syndrome
Phosphorylated 14-3-3zeta protein in the CSF of neuroleptic-treated patients.
Creutzfeldt-Jakob Syndrome
Positive 14-3-3 and tau proteins in a sporadic Creutzfeldt-Jakob disease case and a brief perspective of prion diseases in Colombia.
Creutzfeldt-Jakob Syndrome
Profiles of 14-3-3 and Total Tau in CSF Samples of Chinese Patients of Different Genetic Prion Diseases.
Creutzfeldt-Jakob Syndrome
Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea.
Creutzfeldt-Jakob Syndrome
Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Signs of rapidly progressive dementia in a case of intravascular lymphomatosis.
Creutzfeldt-Jakob Syndrome
Sporadic Creutzfeldt-Jakob disease diagnostic accuracy is improved by a new CSF ELISA 14-3-3? assay.
Creutzfeldt-Jakob Syndrome
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Creutzfeldt-Jakob Syndrome
Tau and 14-3-3 of genetic and sporadic Creutzfeldt-Jakob disease patients in Israel.
Creutzfeldt-Jakob Syndrome
Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.
Creutzfeldt-Jakob Syndrome
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
Creutzfeldt-Jakob Syndrome
The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein.
Creutzfeldt-Jakob Syndrome
The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions.
Creutzfeldt-Jakob Syndrome
The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease.
Creutzfeldt-Jakob Syndrome
The impact of the introduction of the 14-3-3 protein assay in the surveillance of sporadic Creutzfeldt-Jakob disease in Catalonia.
Creutzfeldt-Jakob Syndrome
The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review.
Creutzfeldt-Jakob Syndrome
The role of cerebrospinal fluid proteins as early diagnostic markers for sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Total tau protein in cerebrospinal fluid and diffusion-weighted MRI as an early diagnostic marker for Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein.
Creutzfeldt-Jakob Syndrome
Use of 14-3-3 and other brain-specific proteins in CSF in the diagnosis of variant Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Use of 14-3-3 in the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Validation of 14-3-3 Protein as a Marker in Sporadic Creutzfeldt-Jakob Disease Diagnostic.
Creutzfeldt-Jakob Syndrome
Visual symptoms in the presentation of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
[Analyses of 14-3-3 protein in the cerebrospinal fluid in Creutzfeldt-Jakob disease. Preliminary report]
Creutzfeldt-Jakob Syndrome
[Bacillus anthracis, prions, Coxiella burnetii]
Creutzfeldt-Jakob Syndrome
[Cerebrospinal fluid diagnosis of Creutzfeldt-Jakob disease]
Creutzfeldt-Jakob Syndrome
[Cerebrospinal fluid examination in the infectious meningitis and encephalitis]
Creutzfeldt-Jakob Syndrome
[Clinical algorithm for cerebrospinal fluid test of 14-3-3 protein in diagnosis of Creutzfeldt-Jacob disease]
Creutzfeldt-Jakob Syndrome
[Creutzfeldt-Jakob disease: diagnostic value of protein 14-3-3 and neuronal specific enolase assay in cerebrospinal fluid]
Creutzfeldt-Jakob Syndrome
[Diagnosis of transmissible spongiform encephalopathies in Spain. Population perspective]
Creutzfeldt-Jakob Syndrome
[MM1 variant of sporadic Creutzfeldt-Jakob disease with long duration akinetic mutism state]
Creutzfeldt-Jakob Syndrome
[New investigations in suspected Creutzfeldt-Jakob disease. Analysis of 14-3-3 protein and T-tau in cerebrospinal fluid for safer diagnosis]
Creutzfeldt-Jakob Syndrome
[Proportion of tau protein to phosphorylated tau protein CSF levels in differential diagnosis of dementia]
Creutzfeldt-Jakob Syndrome
[Study on the characteristic of Surveillant Creutzfeldt-Jakob disease patients from January to August in 2006 in China.]
Creutzfeldt-Jakob Syndrome
[Use and validity of the 14-3-3 protein test in the diagnosis of prion diseases: a 4-year prospective study]
Creutzfeldt-Jakob Syndrome
[Usefulness of the 14-3-3 test for the diagnosis of sCJD evaluated by a Spanish reference center.]
Crohn Disease
A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-? Release in Human Lymphoblasts.
Crohn Disease
A new avenue to investigate: the autophagic process. From Crohn's disease to Chlamydia.
Crohn Disease
An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.
Crohn Disease
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
Crohn Disease
Corrigendum: Fusobacterium nucleatum Activates Endoplasmic Reticulum Stress to Promote Crohn's Disease Development via the Upregulation of CARD3 Expression.
Crohn Disease
Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness.
Crohn Disease
Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo.
Crohn Disease
Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response.
Crohn Disease
Dysfunctional Crohn's Disease-Associated NOD2 Polymorphisms Cannot be Reliably Predicted on the Basis of RIPK2 Binding or Membrane Association.
Crohn Disease
Emerging views of mitophagy in immunity and autoimmune diseases.
Crohn Disease
Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus.
Crohn Disease
Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond.
Crohn Disease
Fusobacterium nucleatum Activates Endoplasmic Reticulum Stress to Promote Crohn's Disease Development via the Upregulation of CARD3 Expression.
Crohn Disease
Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.
Crohn Disease
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.
Crohn Disease
How autophagy controls the intestinal epithelial barrier.
Crohn Disease
Inflammatory bowel disease and Parkinson's disease: common pathophysiological links.
Crohn Disease
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
Crohn Disease
Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery.
Crohn Disease
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Crohn Disease
Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).
Crohn Disease
LRRK2 and autophagy: a common pathway for disease.
Crohn Disease
LRRK2 and human disease: a complicated question or a question of complexes?
Crohn Disease
LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
Crohn Disease
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
Crohn Disease
LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.
Crohn Disease
LRRK2 as a negative regulator of NFAT: implications for the pathogenesis of inflammatory bowel disease.
Crohn Disease
LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.
Crohn Disease
LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.
Crohn Disease
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.
Crohn Disease
LRRK2 inhibition attenuates microglial inflammatory responses.
Crohn Disease
LRRK2 is involved in the IFN-gamma response and host response to pathogens.
Crohn Disease
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Crohn Disease
Malassezia and Parkinson's Disease.
Crohn Disease
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Crohn Disease
Number and brightness analysis of LRRK2 oligomerization in live cells.
Crohn Disease
Occurrence of Crohn's disease with Parkinson's disease.
Crohn Disease
Parkinson disease: LRRK2 variants linked to PD and Crohn's disease.
Crohn Disease
Parkinson's disease and immune system: is the culprit LRRKing in the periphery?
Crohn Disease
Parkinson's disease-associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages.
Crohn Disease
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Crohn Disease
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Crohn Disease
Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis.
Crohn Disease
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Crohn Disease
The Neurobiology of LRRK2 and its Role in the Pathogenesis of Parkinson's Disease.
Crohn Disease
Withaferin A Regulates LRRK2 Levels by Interfering with the Hsp90- Cdc37 Chaperone Complex.
Cryptogenic Organizing Pneumonia
Post-Breast Cancer Radiotherapy Bronchiolitis Obliterans Organizing Pneumonia.
Cryptosporidiosis
5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum.
Cryptosporidiosis
7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.
Cryptosporidiosis
A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis.
Cryptosporidiosis
Bumped-Kinase Inhibitors for Therapy of Cryptosporidiosis.
Cryptosporidiosis
Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis.
Cushing Syndrome
A genetic and molecular update on adrenocortical causes of Cushing syndrome.
Cushing Syndrome
A Novel Mutation in the type I? Regulatory Subunit of Protein Kinase A (PRKAR1A) in a Cushing's Syndrome Patient with Primary Pigmented Nodular Adrenocortical Disease.
Cushing Syndrome
A Novel PRKAR1A Mutation Identified in a Patient with Isolated Primary Pigmented Nodular Adrenocortical Disease.
Cushing Syndrome
Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.
Cushing Syndrome
ARMC5 variants in PRKAR1A-mutated patients modify cortisol levels and Cushing's syndrome.
Cushing Syndrome
cAMP signaling in cortisol-producing adrenal adenoma.
Cushing Syndrome
Correction: Genomic and sequence variants of protein kinase A regulatory subunit type 1? (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.
Cushing Syndrome
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
Cushing Syndrome
Expression of serotonin7 receptor and coupling of ectopic receptors to protein kinase A and ionic currents in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome.
Cushing Syndrome
Genomic and sequence variants of protein kinase A regulatory subunit type 1? (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.
Cushing Syndrome
Germline PRKACA amplification causes variable phenotypes that may depend on the extent of the genomic defect: molecular mechanisms and clinical presentations.
Cushing Syndrome
Mechanisms of Aberrant PKA Activation by C? Subunit Mutations.
Cushing Syndrome
Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.
Cushing Syndrome
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Cushing Syndrome
Protein kinase A defects and cortisol-producing adrenal tumors.
Cutis Laxa
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
cyclin-dependent kinase deficiency
CDKL5 Deficiency Disorder-A Complex Epileptic Encephalopathy.
cyclin-dependent kinase deficiency
Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons.
cyclin-dependent kinase deficiency
Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder?
Cystadenocarcinoma, Serous
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
Cystadenocarcinoma, Serous
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Cystadenoma, Serous
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Cystic Fibrosis
A cluster of negative charges at the amino terminal tail of CFTR regulates ATP-dependent channel gating.
Cystic Fibrosis
A SAXS-based ensemble model of the native and phosphorylated regulatory domain of the CFTR.
Cystic Fibrosis
Alternate stimulation of apical CFTR by genistein in epithelia.
Cystic Fibrosis
Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity.
Cystic Fibrosis
Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Cardiomyocytes with disrupted CFTR function require CaMKII and Ca2+-activated Cl- channel activity to maintain contraction rate.
Cystic Fibrosis
Cellular mechanism for potentiation of Ca2+-mediated Cl- secretion by the flavonoid baicalein in intestinal epithelia.
Cystic Fibrosis
CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells.
Cystic Fibrosis
Characterization and localization of the rabbit ocular calcitonin gene-related peptide (CGRP)-receptor component protein (RCP).
Cystic Fibrosis
Chenodeoxycholic Acid Requires Activation of EGFR, EPAC and Ca2+ to Stimulate CFTR-dependent Cl- Secretion in Human Colonic T84 Cells.
Cystic Fibrosis
Chloride secretory response to extracellular ATP in human normal and cystic fibrosis nasal epithelia.
Cystic Fibrosis
Cl- interference with the epithelial Na+ channel ENaC.
Cystic Fibrosis
Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.
Cystic Fibrosis
Cloning and expression of a 5HT7 receptor from Xenopus laevis.
Cystic Fibrosis
Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.
Cystic Fibrosis
Coupling of CFTR Cl- channel gating to an ATP hydrolysis cycle.
Cystic Fibrosis
Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants.
Cystic Fibrosis
Cyclic AMP-related and cation-affected human platelet chloride transport regulation.
Cystic Fibrosis
Cystic fibrosis transmembrane conductance regulator inhibits epithelial Na+ channels carrying Liddle's syndrome mutations.
Cystic Fibrosis
Cystic fibrosis transmembrane conductance regulator is required for protein kinase A activation of an outwardly rectified anion channel purified from bovine tracheal epithelia.
Cystic Fibrosis
Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel.
Cystic Fibrosis
Differential interactions of nucleotides at the two nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells.
Cystic Fibrosis
Effect of anion transport blockers on CFTR in the human sweat duct.
Cystic Fibrosis
Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating.
Cystic Fibrosis
Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis.
Cystic Fibrosis
Epithelial Chloride Transport by CFTR Requires TMEM16A.
Cystic Fibrosis
External ATP and its analogs activate the cystic fibrosis transmembrane conductance regulator by a cyclic AMP-independent mechanism.
Cystic Fibrosis
Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP.
Cystic Fibrosis
G protein G alpha i-2 inhibits outwardly rectifying chloride channels in human airway epithelial cells.
Cystic Fibrosis
How autophagy controls the intestinal epithelial barrier.
Cystic Fibrosis
Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by
Cystic Fibrosis
Hydrogen sulfide: A novel signaling molecule in the central nervous system.
Cystic Fibrosis
Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR.
Cystic Fibrosis
Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectified chloride channels.
Cystic Fibrosis
Lactobacillus casei protects dextran sodium sulfate- or rapamycin-induced colonic inflammation in the mouse.
Cystic Fibrosis
Liquid movement across the surface epithelium of large airways.
Cystic Fibrosis
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Cystic Fibrosis
Lysosomal Reacidification Ameliorates Vinyl Carbamate-Induced Toxicity and Disruption on Lysosomal pH.
Cystic Fibrosis
Mechanistic insight into control of CFTR by AMPK.
Cystic Fibrosis
Modulation of CFTR gating by permeant ions.
Cystic Fibrosis
Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesis.
Cystic Fibrosis
On the mechanism of genistein-induced activation of protein kinase A-dependent Cl- conductance in cardiac myocytes.
Cystic Fibrosis
Opiates inhibit ion conductances elicited by cell swelling and cAMP in cultured cells.
Cystic Fibrosis
Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.
Cystic Fibrosis
Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A.
Cystic Fibrosis
Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA.
Cystic Fibrosis
PKA holoenzyme is functionally coupled to CFTR by AKAPs.
Cystic Fibrosis
PKC regulation of cardiac CFTR Cl- channel function in guinea pig ventricular myocytes.
Cystic Fibrosis
Potent inhibition of the CFTR chloride channel by suramin.
Cystic Fibrosis
Properties of chloride-conductive pathways in rat kidney cortical and outer-medulla brush-border membranes--inhibition by anti-(cystic fibrosis transmembrane regulator) mAbs.
Cystic Fibrosis
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel.
Cystic Fibrosis
Prostaglandin E2 induces chloride secretion through crosstalk between cAMP and calcium signaling in mouse inner medullary collecting duct cells.
Cystic Fibrosis
Prostaglandin F2alpha stimulates CFTR activity by PKA- and PKC-dependent phosphorylation.
Cystic Fibrosis
Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin.
Cystic Fibrosis
Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene.
Cystic Fibrosis
Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the deltaF508 mutation: F508 deletion disrupts a kinase-binding site.
Cystic Fibrosis
Protein phosphorylation responses in normal and cystic fibrosis airway epithelial cell lines.
Cystic Fibrosis
R-Domain Phosphorylation by Protein Kinase A Stimulates Dissociation of Unhydrolyzed ATP from the First Nucleotide-Binding Site of the Cystic Fibrosis Transmembrane Conductance Regulator.
Cystic Fibrosis
Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi.
Cystic Fibrosis
Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model.
Cystic Fibrosis
Rectal epithelial expression of protein kinase A phosphorylation of cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Regulation of CFTR channel gating.
Cystic Fibrosis
Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis.
Cystic Fibrosis
Regulation of the ROMK channel: interaction of the ROMK with associate proteins.
Cystic Fibrosis
Removal of the Fe(iii) site promotes activation of the human cystic fibrosis transmembrane conductance regulator by high-affinity Zn(ii) binding.
Cystic Fibrosis
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.
Cystic Fibrosis
Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A.
Cystic Fibrosis
Role of the actin cytoskeleton in the regulation of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Small interfering peptide (siP) for in vivo examination of the developing lung interactonome.
Cystic Fibrosis
Stimulation of cystic fibrosis transmembrane conductance regulator-dependent short-circuit currents across DeltaF508 murine intestines.
Cystic Fibrosis
Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Structural features of Escherichia coli heat-stable enterotoxin that activates membrane-associated guanylyl cyclase.
Cystic Fibrosis
Targeted inactivation of cystic fibrosis transmembrane conductance regulator chloride channel gene prevents ischemic preconditioning in isolated mouse heart.
Cystic Fibrosis
The phorbol ester PMA and cyclic AMP activate different Cl(-) and HCO3(-) fluxes in C127 cells expressing CFTR.
Cystic Fibrosis
THE SHARK RECTAL GLAND MODEL: A CHAMPION OF RECEPTOR MEDIATED CHLORIDE SECRETION THROUGH CFTR.
Cystic Fibrosis
Tolbutamide causes open channel blockade of cystic fibrosis transmembrane conductance regulator Cl- channels.
Cystic Fibrosis
Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.
Cystic Fibrosis
Type II protein kinase A regulates CFTR in airway, pancreatic, and intestinal cells.
Cystic Fibrosis
Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes.
Cystic Fibrosis
Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells.
Cysticercosis
Immunodiagnosis of porcine cysticercosis: identification of candidate antigens through immunoproteomics.
Cystitis
Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis.
Cystitis
Role of c-Jun N-Terminal Kinase (JNK) Activation in Micturition Reflexes in Cyclophosphamide (CYP)-Induced Cystitis in Female Rats.
Cystitis
The c-Jun N-terminal kinase (JNK) pathway is activated in human interstitial cystitis (IC) and rat protamine sulfate induced cystitis.
Cystitis, Interstitial
The c-Jun N-terminal kinase (JNK) pathway is activated in human interstitial cystitis (IC) and rat protamine sulfate induced cystitis.
Cysts
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Cysts
14-3-3 protein beta/alpha as a urinary biomarker for renal cell carcinoma: proteomic analysis of cyst fluid.
Cysts
A Pak-regulated cell intercalation event leading to a novel radial cell polarity is involved in positioning of the follicle stem cell niche in the Drosophila ovary.
Cysts
A Systematic Review of In vitro and In vivo Activities of Anti-Toxoplasma Drugs and Compounds (2006-2016).
Cysts
Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes.
Cysts
Cold-induced cysts of the photosynthetic dinoflagellate Lingulodinium polyedrum have an arrested circadian bioluminescence rhythm and lower levels of protein phosphorylation.
Cysts
cut interacts with Notch and protein kinase A to regulate egg chamber formation and to maintain germline cyst integrity during Drosophila oogenesis.
Cysts
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys.
Cysts
Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.
Cysts
Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts.
Cysts
Enhanced resistance to soybean cyst nematode Heterodera glycines in transgenic soybean by silencing putative CLE receptors.
Cysts
Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease.
Cysts
Immune responses and protection after DNA vaccination against Toxoplasma gondii calcium-dependent protein kinase 2 (TgCDPK2).
Cysts
Interaction network of the 14-3-3 protein in the ancient protozoan parasite Giardia duodenalis.
Cysts
Nematotoxicity of Paeonia spp. Extracts and Camellia oleifera Tea Seed Cake and Extracts to Heterodera glycines and Meloidogyne incognita.
Cysts
Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring.
Cysts
Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model.
Cysts
pVHL and GSK3beta are components of a primary cilium-maintenance signalling network.
Cysts
Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model.
Cysts
Relative expression of the 14-3-3 gene in different morphotypes of cysts of Echinococcus granulosus isolated from the Indian buffalo.
Cysts
Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.
Cysts
Synergistic Interaction of CLAVATA1, CLAVATA2, and RECEPTOR-LIKE PROTEIN KINASE 2 in Cyst Nematode Parasitism of Arabidopsis.
Cysts
The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.
Cysts
Yield and Clinical Utility of Next-Generation Sequencing in Selected Patients With Lung Adenocarcinoma.
Cytomegalovirus Infections
Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection.
De Lange Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Death, Sudden, Cardiac
A molecular formula for heart failure and sudden cardiac death. Focus on "Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice".
Death, Sudden, Cardiac
Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators.
Death, Sudden, Cardiac
Novel therapy for heart failure and exercise-induced ventricular tachycardia based on 'fixing' the leak in ryanodine receptors.
Death, Sudden, Cardiac
Synergy between CaMKII substrates and ?-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
Death, Sudden, Cardiac
The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias.
Dehydration
14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: transcriptomic and proteomic studies.
Dehydration
A gene expression analysis of syncytia laser microdissected from the roots of the Glycine max (soybean) genotype PI 548402 (Peking) undergoing a resistant reaction after infection by Heterodera glycines (soybean cyst nematode).
Dehydration
AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts.
Dehydration
Autophosphorylation and subcellular localization dynamics of a salt- and water deficit-induced calcium-dependent protein kinase from ice plant.
Dehydration
Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments.
Dehydration
Effect of water stress on cell division and cell-division-cycle 2-like cell-cycle kinase activity in wheat leaves
Dehydration
Gene expression in two contrasting hybrid clones of Eucalyptus camaldulensis x Eucalyptus urophylla grown under water deficit conditions.
Dehydration
Involvement of 14-3-3 protein GRF9 in root growth and response under polyethylene glycol-induced water stress.
Dehydration
Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus.
Dehydration
Microbes in Cahoots with Plants: MIST to Hit the Jackpot of Agricultural Productivity during Drought.
Dehydration
Physiological and molecular responses for long term salinity stress in common fig (Ficus carica L.).
Dehydration
Second messenger and cAMP-dependent protein kinase responses to dehydration and anoxia stresses in frogs.
Dementia
14-3-3 protein cerebrospinal fluid detection in human growth hormone-treated Creutzfeldt-Jakob disease patients.
Dementia
14-3-3 protein in the CSF of patients with rapidly progressive dementia.
Dementia
14-3-3 protein, total tau and phosphorylated tau in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease and neurodegenerative disease in Japan.
Dementia
14-3-3 {gamma}-isoform detection distinguishes sporadic Creutzfeldt-Jakob disease from other dementias.
Dementia
A practical approach to avoiding iatrogenic Creutzfeldt-Jakob disease (CJD) from invasive instruments.
Dementia
A rare case of rapidly progressive dementia with elevated RT-QuIC and negative 14-3-3 and tau proteins.
Dementia
A specific group of patients with diagnostic conversion from depression to bipolar disorder and finally to dementia as a mental GSK-3 disease: A hypothesis.
Dementia
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Dementia
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.
Dementia
Additional value of tau protein measurement in the diagnosis of Creutzfeldt-Jakob disease.
Dementia
Alzheimer's and Hyperglycemia: Role of the Insulin Signaling Pathway and GSK-3 Inhibition in Paving a Path to Dementia.
Dementia
Analysis of 50 Neurodegenerative Genes in Clinically Diagnosed Early-Onset Alzheimer's Disease.
Dementia
Anti-N-methyl-D-Aspartate Receptor Encephalitis Mimicking Sporadic Creutzfeldt-Jakob Disease.
Dementia
Applicability of long-term electroencephalography in pre-mortem diagnosis of Creutzfeldt-Jakob disease: A case report.
Dementia
Association of cerebrospinal fluid prion protein levels and the distinction between Alzheimer disease and creutzfeldt-jakob disease.
Dementia
Autoimmune Encephalitis Resembling Dementia Syndromes.
Dementia
Autonomic dysfunction in genetic forms of synucleinopathies.
Dementia
Autopsy-diagnosed neurodegenerative dementia cases support the use of cerebrospinal fluid protein biomarkers in the diagnostic work-up.
Dementia
Biochemical investigations in patients with dementia.
Dementia
Calcineurin Inhibition and Protein Kinase A Activation Limits Cognitive Dysfunction and Histopathological Damage in a Model of Dementia of the Alzheimer's Type.
Dementia
Calcium/calmodulin-dependent kinase II and Alzheimer's disease.
Dementia
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Dementia
Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years.
Dementia
Cerebrospinal Fluid Biomarker-Based Diagnosis of Sporadic Creutzfeldt-Jakob Disease: A Validation Study for Previously Established Cutoffs.
Dementia
Cerebrospinal fluid biomarkers in clinically isolated syndromes and multiple sclerosis.
Dementia
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.
Dementia
Clinical and Pathological Characteristics of LRRK2 G2019S Patients with PD.
Dementia
Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease.
Dementia
Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type 2.
Dementia
Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.
Dementia
Comatose within 6 weeks, but still alive after 3 years, Creutzfeldt-Jakob disease with unusual progression.
Dementia
Comparison between plasma and cerebrospinal fluid biomarkers for the early diagnosis and association with survival in prion disease.
Dementia
CSF detection of the 14-3-3 protein in unselected patients with dementia.
Dementia
Determination of 14-3-3 protein levels in cerebrospinal fluid from Creutzfeldt-Jakob patients by a highly sensitive capture assay.
Dementia
Development of a dot blot assay with antibodies to recombinant "core" 14-3-3 protein: Evaluation of its usefulness in diagnosis of Creutzfeldt-Jakob disease.
Dementia
Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients.
Dementia
Diagnostic value of surrogate CSF biomarkers for Creutzfeldt-Jakob disease in the era of RT-QuIC.
Dementia
Differential diagnosis of 201 possible Creutzfeldt-Jakob disease patients.
Dementia
Diffusion-weighted MRI in Creutzfeldt-Jakob disease: a better diagnostic marker than CSF protein 14-3-3?
Dementia
Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.
Dementia
Effect of Huannao Yicong Prescription () extract on ?-Amyloid precursor protein metabolic signal transduction-related protein in brain tissue of dementia model transgenic mouse.
Dementia
Ginkgo biloba leaf extract improves the cognitive abilities of rats with D-galactose induced dementia.
Dementia
Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.
Dementia
Glycogen synthase kinase-3 inhibition as a potential pharmacological target for vascular dementia: In silico and in vivo evidence.
Dementia
Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.
Dementia
High Diagnostic Accuracy of RT-QuIC Assay in a Prospective Study of Patients with Suspected sCJD.
Dementia
Highlighting the protective or degenerative role of AMPK activators in dementia experimental models.
Dementia
How many biomarkers to discriminate neurodegenerative dementia?
Dementia
How to improve the clinical diagnosis of Creutzfeldt-Jakob disease.
Dementia
Identification of Somatic Mutations in Dementia-related Genes in Cancer Patients.
Dementia
Identification of Three Novel LRRK2 Mutations associated with Parkinson's Disease in a Calabrian Population.
Dementia
Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction.
Dementia
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
Dementia
Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases.
Dementia
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Dementia
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Dementia
Lithium treatment and risk for dementia in adults with bipolar disorder: population-based cohort study.
Dementia
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.
Dementia
LRRK2 and neurodegeneration.
Dementia
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Dementia
LRRK2 in Parkinson's disease and dementia with Lewy bodies.
Dementia
LRRK2 mutations are not common in Alzheimer's disease.
Dementia
LRRK2 variation and dementia with Lewy bodies.
Dementia
Lymphomatosis cerebri presenting as rapidly progressive dementia.
Dementia
Magnetic resonance spectroscopy and measurement of tau epitopes of autopsy proven sporadic Creutzfeldt-Jakob disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 immunoblot.
Dementia
microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.
Dementia
Mutation Analysis of the Genes Associated with Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia.
Dementia
N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells.
Dementia
Novel prion protein gene mutation in an octogenarian with Creutzfeldt-Jakob disease.
Dementia
Pharmacological activation of protein kinase A improves memory loss and neuropathological changes in a mouse model of dementia of Alzheimer's type.
Dementia
Phosphorylated 14-3-3zeta protein in the CSF of neuroleptic-treated patients.
Dementia
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
Dementia
Proteome analysis in the clinical chemistry laboratory: myth or reality?
Dementia
PTEN? Modulates CaMKII Signaling and Controls Contextual Fear Memory and Spatial Learning.
Dementia
Recent advances in the genetics of dementia with lewy bodies.
Dementia
Role of LRRK2 variant p.Gly2019Ser in patients with Parkinsonism.
Dementia
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Dementia
T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model.
Dementia
The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.
Dementia
The complex relationship between genotype, pathology and phenotype in familial dementia.
Dementia
The genetic landscape of Parkinson's disease.
Dementia
The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.
Dementia
What genetics tells us about the causes and mechanisms of Parkinson's disease.
Dementia
Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice.
Dementia
[Analysis for clinical and genetic characteristics of a sporadic FFI case]
Dementia
[CSF analysis of patients with prion disease by biomarkers and real-time qucking-induced conversion (RT-QUIC) method].
Dementia
[Roles of Mammalian Target of Rapamycin Signaling and Autophagy Pathway in Alzheimer's Disease].
Dementia, Vascular
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Dementia, Vascular
Effects of electroacupuncture on the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of rats with vascular dementia.
Dementia, Vascular
Glycogen synthase kinase-3 inhibition as a potential pharmacological target for vascular dementia: In silico and in vivo evidence.
Dementia, Vascular
LRRK2 G2019S and I2020T mutations are not common in Alzheimer's disease and vascular dementia.
Dementia, Vascular
Signs of rapidly progressive dementia in a case of intravascular lymphomatosis.
Dementia, Vascular
Upregulated expression of 14-3-3 proteins in astrocytes from human cerebrovascular ischemic lesions.
Dementia, Vascular
[Eleven years of autopsy on account of Creutzfeldt-Jakob disease in the Netherlands]
Demyelinating Diseases
Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate.
Demyelinating Diseases
Biochemical markers of damage of the central nervous system in multiple sclerosis.
Demyelinating Diseases
Increased 14-3-3 immunoreactivity in glial elements in patients with multiple sclerosis.
Demyelinating Diseases
Increased activation of the epidermal growth factor receptor in transgenic mice overexpressing epigen causes peripheral neuropathy.
Demyelinating Diseases
Role of glial 14-3-3 gamma protein in autoimmune demyelination.
Demyelinating Diseases
The 14-3-3 protein in multiple sclerosis: a marker of disease severity.
Dengue
Cell death gene expression profile: role of RIPK2 in dengue virus-mediated apoptosis.
Dengue
Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation.
Dengue
Identification and characterization of the role of c-terminal Src kinase in dengue virus replication.
Dengue
IDENTIFICATION AND EXPRESSION ANALYSIS OF TWO 14-3-3 PROTEINS IN THE MOSQUITO Aedes aegypti, AN IMPORTANT ARBOVIRUSES VECTOR.
Dengue
Single-Nucleotide Polymorphisms in NOD1, RIPK2, MICB, PLCE1, TNF, and IKBKE Genes Associated with Symptomatic Dengue in Children from Colombia.
Dengue
Viral strategies for triggering and manipulating mitophagy.
Dermatitis
Anti-inflammatory and immune response regulation of Si-Ni-San in 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin dysfunction.
Dermatitis
Extract of Polygala tenuifolia Alleviates Stress-Exacerbated Atopy-Like Skin Dermatitis through the Modulation of Protein Kinase A and p38 Mitogen-Activated Protein Kinase Signaling Pathway.
Dermatitis, Allergic Contact
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Dermatitis, Atopic
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Dermatitis, Atopic
Functional study of 14-3-3 protein epsilon (YWHAE) in keratinocytes: microarray integrating bioinformatics approaches.
Dermatitis, Atopic
Intracellular 3',5'-adenosine cyclic monophosphate level regulates house dust mite-induced interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis.
Dermatitis, Atopic
Red ginseng extracts attenuate skin inflammation in atopic dermatitis through p70 ribosomal protein S6 kinase activation.
Dermatitis, Contact
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Dermatofibrosarcoma
Alteration of PDGFR?-Akt-mTOR Pathway Signaling in Fibrosarcomatous Transformation of Dermatofibrosarcoma Protuberans.
Diabetes Complications
Cutaneous expression of calcium/calmodulin-dependent protein kinase II in rats with type 1 and type 2 diabetes.
Diabetes Complications
Protein kinase C? activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation.
Diabetes Insipidus
Expression of a dominant negative Protein Kinase A (PKA) mutation in kidney elicits a diabetes insipidus phenotype.
Diabetes Insipidus, Nephrogenic
Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus.
Diabetes Insipidus, Nephrogenic
GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity.
Diabetes Insipidus, Nephrogenic
Lithium and nephrotoxicity: Unravelling the complex pathophysiological threads of the lightest metal.
Diabetes Mellitus
3D-QSAR and Molecular Docking Studies on 3-Anilino-4-Arylmaleimide Derivatives as Glycogen Synthase Kinase-3? Inhibitors.
Diabetes Mellitus
3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3beta inhibitors.
Diabetes Mellitus
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Diabetes Mellitus
A proteoglycan extract from Ganoderma Lucidum protects pancreatic beta-cells against STZ-induced apoptosis.
Diabetes Mellitus
Activation of CaMKII as a key regulator of reactive oxygen species production in diabetic rat heart.
Diabetes Mellitus
Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy.
Diabetes Mellitus
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Diabetes Mellitus
Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3? inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance.
Diabetes Mellitus
Atypical protein kinase C in glucose metabolism.
Diabetes Mellitus
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus
Changes of calcium/calmodulin-dependent protein kinase II expression in dorsal root ganglia during maturation in long-term diabetes.
Diabetes Mellitus
Curcumin anti-diabetic effect mainly correlates with its anti-apoptotic actions and PI3K/Akt signal pathway regulation in the liver.
Diabetes Mellitus
Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-?B signaling pathways after streptozotocin-induced diabetes mellitus.
Diabetes Mellitus
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation.
Diabetes Mellitus
Dietary Methionine Restriction Alleviates Hyperglycemia in Pigs with Intrauterine Growth Restriction by Enhancing Hepatic Protein Kinase B Signaling and Glycogen Synthesis.
Diabetes Mellitus
Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors.
Diabetes Mellitus
DL-3-n-butylphthalide (NBP) ameliorates cognitive deficits and CaMKII-mediated long-term potentiation impairment in the hippocampus of diabetic db/db mice.
Diabetes Mellitus
Dominant negative 14-3-3 promotes cardiomyocyte apoptosis in early stage of type I diabetes mellitus through activation of JNK.
Diabetes Mellitus
Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
Diabetes Mellitus
Effects of Selenium and Exendin-4 on Glucagon-Like Peptide-1 Receptor, IRS-1, and Raf-1 in the Liver of Diabetic Rats.
Diabetes Mellitus
Enhanced CaMKII-Dependent Late INa Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.
Diabetes Mellitus
Expression characteristics of proteins of IGF-1R, p-Akt, and survivin in papillary thyroid carcinoma patients with type 2 diabetes mellitus.
Diabetes Mellitus
GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.
Diabetes Mellitus
Glucose variability aggravates cardiac fibrosis by altering AKT signalling path.
Diabetes Mellitus
Glycogen synthase kinase 3 in Wnt signaling pathway and cancer.
Diabetes Mellitus
Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review.
Diabetes Mellitus
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
Diabetes Mellitus
GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics.
Diabetes Mellitus
Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.
Diabetes Mellitus
Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus.
Diabetes Mellitus
Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from Type II diabetic subjects.
Diabetes Mellitus
Inhibition of glycogen synthase kinase-3.
Diabetes Mellitus
Insulin Signaling, GSK-3, Heat Shock Proteins and the Natural History of Type 2 Diabetes Mellitus: A Hypothesis.
Diabetes Mellitus
Kalpaamruthaa modulates oxidative stress in cardiovascular complication associated with type 2 diabetes mellitus through PKC-?/Akt signaling.
Diabetes Mellitus
Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice.
Diabetes Mellitus
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
Diabetes Mellitus
LncRNA NONRATT021972 siRNA normalized the dysfunction of hepatic glucokinase through AKT signaling in T2DM rats.
Diabetes Mellitus
Mechanism of improving effect of losartan on insulin sensitivity of non-insulin-dependent diabetes mellitus rats.
Diabetes Mellitus
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.
Diabetes Mellitus
New leads for selective GSK-3 inhibition: pharmacophore mapping and virtual screening studies.
Diabetes Mellitus
O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure.
Diabetes Mellitus
Oxidative CaMKII as a potential target for inflammatory disease (Review).
Diabetes Mellitus
p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus.
Diabetes Mellitus
PLS and shape-based similarity analysis of maleimides - GSK-3 inhibitors.
Diabetes Mellitus
Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.
Diabetes Mellitus
RNA-Seq Analysis of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the Zucker Diabetic Fatty Rats.
Diabetes Mellitus
Role of Glycogen synthase kinase-3 in the etiology of Type 2 Diabetes Mellitus: A review.
Diabetes Mellitus
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
Diabetes Mellitus
Selectivity criterion for pyrazolo[3,4-b]pyrid[az]ine derivatives as GSK-3 inhibitors: CoMFA and molecular docking studies.
Diabetes Mellitus
Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats.
Diabetes Mellitus
Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models.
Diabetes Mellitus
STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus.
Diabetes Mellitus
Structure-based approaches in the design of GSK-3 selective inhibitors.
Diabetes Mellitus
The expression of calcium/calmodulin-dependent protein kinase II in the dorsal horns of rats with type 1 and type 2 diabetes.
Diabetes Mellitus
The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus.
Diabetes Mellitus
The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus.
Diabetes Mellitus
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.
Diabetes Mellitus
Valsartan improves cardiac function in mice with diabetes mellitus by CaMKII/AngII.
Diabetes Mellitus
[Genes and molecular mechanisms affecting the correlation between liver cancer and diabetes mellitus].
Diabetes Mellitus
[Modulating effects of protein kinase A on intracellular signal systems in the course of skin wound healing in patients with diabetes mellitus]
Diabetes Mellitus, Type 1
Alzheimer-like changes in rat models of spontaneous diabetes.
Diabetes Mellitus, Type 1
Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetes.
Diabetes Mellitus, Type 1
GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.
Diabetes Mellitus, Type 1
In vivo effects of insulin and bis(maltolato)oxovanadium (IV) on PKB activity in the skeletal muscle and liver of diabetic rats.
Diabetes Mellitus, Type 1
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.
Diabetes Mellitus, Type 2
?-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells.
Diabetes Mellitus, Type 2
A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes.
Diabetes Mellitus, Type 2
A proteoglycan extract from Ganoderma Lucidum protects pancreatic beta-cells against STZ-induced apoptosis.
Diabetes Mellitus, Type 2
Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy.
Diabetes Mellitus, Type 2
AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes.
Diabetes Mellitus, Type 2
AMPK in the small intestine in normal and pathophysiological conditions.
Diabetes Mellitus, Type 2
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Diabetes Mellitus, Type 2
Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology.
Diabetes Mellitus, Type 2
Anti-obesity effects of 3-hydroxychromone derivative, a novel small-molecule inhibitor of glycogen synthase kinase-3.
Diabetes Mellitus, Type 2
Antisense inhibition of S6 kinase 1 produces improved glucose tolerance and is well tolerated for 4 weeks of treatment in rats.
Diabetes Mellitus, Type 2
Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape.
Diabetes Mellitus, Type 2
Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China.
Diabetes Mellitus, Type 2
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus, Type 2
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus, Type 2
Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases.
Diabetes Mellitus, Type 2
c-Jun N-terminal kinase pathways in diabetes.
Diabetes Mellitus, Type 2
Calmodulin dependent protein kinase II activation by exercise regulates saturated & unsaturated fatty acids and improves some metabolic syndrome markers.
Diabetes Mellitus, Type 2
CARD3 deficiency exacerbates diet-induced obesity, hepatosteatosis, and insulin resistance in male mice.
Diabetes Mellitus, Type 2
Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment.
Diabetes Mellitus, Type 2
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM.
Diabetes Mellitus, Type 2
Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.
Diabetes Mellitus, Type 2
Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.
Diabetes Mellitus, Type 2
Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.
Diabetes Mellitus, Type 2
Curcumin anti-diabetic effect mainly correlates with its anti-apoptotic actions and PI3K/Akt signal pathway regulation in the liver.
Diabetes Mellitus, Type 2
Depletion of PAK1 enhances Ubiquitin-mediated Survivin degradation in pancreatic ?-cells.
Diabetes Mellitus, Type 2
Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay.
Diabetes Mellitus, Type 2
Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.
Diabetes Mellitus, Type 2
Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.
Diabetes Mellitus, Type 2
Dietary Methionine Restriction Alleviates Hyperglycemia in Pigs with Intrauterine Growth Restriction by Enhancing Hepatic Protein Kinase B Signaling and Glycogen Synthesis.
Diabetes Mellitus, Type 2
DL-3-n-butylphthalide (NBP) ameliorates cognitive deficits and CaMKII-mediated long-term potentiation impairment in the hippocampus of diabetic db/db mice.
Diabetes Mellitus, Type 2
Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetes.
Diabetes Mellitus, Type 2
Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats.
Diabetes Mellitus, Type 2
Effects of CaMKII-Mediated Phosphorylation of Ryanodine Receptor Type 2 on Islet Calcium Handling, Insulin Secretion, and Glucose Tolerance.
Diabetes Mellitus, Type 2
Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
Diabetes Mellitus, Type 2
Effects of pomegranate aril juice and its punicalagin on some key regulators of insulin resistance and oxidative liver injury in streptozotocin-nicotinamide type 2 diabetic rats.
Diabetes Mellitus, Type 2
Exendin-4 stimulates autophagy in pancreatic ?-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis.
Diabetes Mellitus, Type 2
Exercise, CaMKII, and type 2 diabetes.
Diabetes Mellitus, Type 2
Expression characteristics of proteins of IGF-1R, p-Akt, and survivin in papillary thyroid carcinoma patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
Diabetes Mellitus, Type 2
Glycogen synthase kinase 3: a key regulator of cellular fate.
Diabetes Mellitus, Type 2
Glycogen synthase kinase 3: an emerging therapeutic target.
Diabetes Mellitus, Type 2
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.
Diabetes Mellitus, Type 2
Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells.
Diabetes Mellitus, Type 2
Glycogen synthase kinase-3 - a promising therapeutic target: Dr Hagit Eldar-Finkelman interviewed by Emma Quigley.
Diabetes Mellitus, Type 2
Glycogen synthase kinase-3 as drug target: from wallflower to center of attention.
Diabetes Mellitus, Type 2
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
Diabetes Mellitus, Type 2
Glycogen synthase kinase-3: The missing link to aberrant circuit function in disorders of cognitive dysfunction?
Diabetes Mellitus, Type 2
GSK-3 as potential target for therapeutic intervention in cancer.
Diabetes Mellitus, Type 2
GSK-3 Inhibitors: A new class of drugs for Alzheimer's Disease Treatment.
Diabetes Mellitus, Type 2
GSK-3: tricks of the trade for a multi-tasking kinase.
Diabetes Mellitus, Type 2
High glucose and insulin in combination cause insulin receptor substrate-1 and -2 depletion and protein kinase B desensitisation in primary cultured rat adipocytes: possible implications for insulin resistance in type 2 diabetes.
Diabetes Mellitus, Type 2
Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment.
Diabetes Mellitus, Type 2
In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity.
Diabetes Mellitus, Type 2
In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes.
Diabetes Mellitus, Type 2
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.
Diabetes Mellitus, Type 2
Individual Radiosensitivity Assessment of the Families of Ataxia-Telangiectasia Patients by G2-Checkpoint Abrogation.
Diabetes Mellitus, Type 2
Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.
Diabetes Mellitus, Type 2
Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc.
Diabetes Mellitus, Type 2
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression.
Diabetes Mellitus, Type 2
Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.
Diabetes Mellitus, Type 2
Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review.
Diabetes Mellitus, Type 2
Insulin Signaling, GSK-3, Heat Shock Proteins and the Natural History of Type 2 Diabetes Mellitus: A Hypothesis.
Diabetes Mellitus, Type 2
Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.
Diabetes Mellitus, Type 2
Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.
Diabetes Mellitus, Type 2
Interactive Association Between Intronic Polymorphism (rs10506151) of the LRRK2 Gene and Type 2 Diabetes on Neurodegenerative Diseases.
Diabetes Mellitus, Type 2
Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model.
Diabetes Mellitus, Type 2
Kalpaamruthaa modulates oxidative stress in cardiovascular complication associated with type 2 diabetes mellitus through PKC-?/Akt signaling.
Diabetes Mellitus, Type 2
LncRNA NONRATT021972 siRNA normalized the dysfunction of hepatic glucokinase through AKT signaling in T2DM rats.
Diabetes Mellitus, Type 2
Long-Term Treatment with Novel Glycogen Synthase Kinase-3 Inhibitor Improves Glucose Homeostasis in ob/ob Mice: Molecular Characterization in Liver and Muscle.
Diabetes Mellitus, Type 2
Mapping and association studies of diabetes related genes in the pig.
Diabetes Mellitus, Type 2
Mechanism of improving effect of losartan on insulin sensitivity of non-insulin-dependent diabetes mellitus rats.
Diabetes Mellitus, Type 2
Mitochondria and GSK-3beta in cardioprotection against ischemia/reperfusion injury.
Diabetes Mellitus, Type 2
p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet ?-cells.
Diabetes Mellitus, Type 2
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Diabetes Mellitus, Type 2
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
Diabetes Mellitus, Type 2
Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders.
Diabetes Mellitus, Type 2
PLS and shape-based similarity analysis of maleimides - GSK-3 inhibitors.
Diabetes Mellitus, Type 2
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
Diabetes Mellitus, Type 2
PPAR? promotes diabetes-associated centrosome amplification via increasing the expression of SKA1 directly at the transcriptional level.
Diabetes Mellitus, Type 2
PRAS40: target or modulator of mTORC1 signalling and insulin action?
Diabetes Mellitus, Type 2
Prevention of fat-induced insulin resistance by salicylate.
Diabetes Mellitus, Type 2
Protection of INS-1 cells from free fatty acid-induced apoptosis by inhibiting the glycogen synthase kinase-3.
Diabetes Mellitus, Type 2
Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo.
Diabetes Mellitus, Type 2
Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes.
Diabetes Mellitus, Type 2
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
Diabetes Mellitus, Type 2
Restraining PI3K: mTOR signalling goes back to the membrane.
Diabetes Mellitus, Type 2
RNA-Seq Analysis of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the Zucker Diabetic Fatty Rats.
Diabetes Mellitus, Type 2
Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes.
Diabetes Mellitus, Type 2
Role of CaMKII in the regulation of fatty acids and lipid metabolism.
Diabetes Mellitus, Type 2
Role of exercise-induced calmodulin protein kinase (CAMK)II activation in the regulation of omega-6 fatty acids and lipid metabolism genes in rat skeletal muscle.
Diabetes Mellitus, Type 2
Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.
Diabetes Mellitus, Type 2
Role of glycogen synthase kinase-3 in skeletal muscle insulin resistance in Type 2 diabetes.
Diabetes Mellitus, Type 2
Role of Glycogen synthase kinase-3 in the etiology of Type 2 Diabetes Mellitus: A review.
Diabetes Mellitus, Type 2
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance.
Diabetes Mellitus, Type 2
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
Diabetes Mellitus, Type 2
Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
Diabetes Mellitus, Type 2
Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.
Diabetes Mellitus, Type 2
Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats.
Diabetes Mellitus, Type 2
Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply.
Diabetes Mellitus, Type 2
Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes.
Diabetes Mellitus, Type 2
STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome.
Diabetes Mellitus, Type 2
Structural basis for compound C inhibition of the human AMP-activated protein kinase ?2 subunit kinase domain.
Diabetes Mellitus, Type 2
Targeted disruption of ROCK1 causes insulin resistance in vivo.
Diabetes Mellitus, Type 2
Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes.
Diabetes Mellitus, Type 2
Targeting glycogen synthase kinase-3 in insulin signalling.
Diabetes Mellitus, Type 2
The C Allele of ATM rs11212617 Associates With Higher Pathological Complete Remission Rate in Breast Cancer Patients Treated With Neoadjuvant Metformin.
Diabetes Mellitus, Type 2
The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1? signalling pathway.
Diabetes Mellitus, Type 2
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.
Diabetes Mellitus, Type 2
The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.
Diabetes Mellitus, Type 2
Tissue-specific analysis of glycogen synthase kinase-3? (GSK-3?) in glucose metabolism: effect of strain variation.
Diabetes Mellitus, Type 2
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.
Diabetes Mellitus, Type 2
Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes.
Diabetes Mellitus, Type 2
Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3?.
Diabetes Mellitus, Type 2
[Modulating effects of protein kinase A on intracellular signal systems in the course of skin wound healing in patients with diabetes mellitus]
Diabetes, Gestational
A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation.
Diabetes, Gestational
Effects of insulin intervention on the expression of VE-cadherin, ?-catenin, Annexin A2, Annexin A5, and 14-3-3 protein in the placentas of patients with gestational diabetes mellitus.
Diabetes, Gestational
Expression of PI3-K, PKB and GSK-3 ? in the skeletal muscle tissue of gestational diabetes mellitus.
Diabetes, Gestational
The genetic polymorphism in the STK11 does not affect gestational diabetes.
Diabetes, Gestational
Vanadate enhances but does not normalize glucose transport and insulin receptor phosphorylation in skeletal muscle from obese women with gestational diabetes mellitus.
Diabetic Angiopathies
Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis.
Diabetic Cardiomyopathies
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Activation of HIF-1 by metallothionein contributes to cardiac protection in the diabetic heart.
Diabetic Cardiomyopathies
Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
Diabetic Cardiomyopathies
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.
Diabetic Cardiomyopathies
CaMKII Inhibition is a Novel Therapeutic Strategy to Prevent Diabetic Cardiomyopathy.
Diabetic Cardiomyopathies
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol.
Diabetic Cardiomyopathies
Inactivation of GSK-3{beta} by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage and remodeling.
Diabetic Cardiomyopathies
Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression.
Diabetic Cardiomyopathies
Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model.
Diabetic Cardiomyopathies
Protein Kinases as Drug Development Targets for Heart Disease Therapy.
Diabetic Cardiomyopathies
RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation.
Diabetic Cardiomyopathies
Role of 14-3-3 protein and oxidative stress in diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3? and p38?/MAPK in a rat model of diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Transplanted bone marrow mesenchymal stem cells protects myocardium by regulating 14-3-3 protein in a rat model of diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Valsartan improves cardiac function in mice with diabetes mellitus by CaMKII/AngII.
Diabetic Foot
[State of intracellular signaling systems in endothelial dysfunction]
Diabetic Nephropathies
Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease.
Diabetic Nephropathies
Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology.
Diabetic Nephropathies
Apoptosis occurs differentially according to glomerular size in diabetic kidney disease.
Diabetic Nephropathies
Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K/AKT pathway.
Diabetic Nephropathies
CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.
Diabetic Nephropathies
Gallic acid ameliorates renal functions by inhibiting the activation of p38 MAPK in experimentally induced type 2 diabetic rats and cultured rat proximal tubular epithelial cells.
Diabetic Nephropathies
Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system.
Diabetic Nephropathies
Lycopene ameliorates renal function in rats with streptozotocin-induced diabetes.
Diabetic Nephropathies
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.
Diabetic Nephropathies
Protein kinase B/Akt regulation in diabetic kidney disease.
Diabetic Nephropathies
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Diabetic Nephropathies
Resveratrol attenuates renal hypertrophy in early-stage diabetes by activating AMPK.
Diabetic Nephropathies
RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose.
Diabetic Nephropathies
Rituximab regulates the expression of the Raf kinase inhibitor protein via NF-?B in renal tissue of rats with diabetic nephropathy.
Diabetic Nephropathies
ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy.
Diabetic Nephropathies
Role of HIPK2 in kidney fibrosis.
Diabetic Nephropathies
SP600125 suppresses
Diabetic Nephropathies
Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway.
Diabetic Nephropathies
Targeting mammalian serine/threonine-protein kinase 4 through Yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis.
Diabetic Nephropathies
The effects of microRNA-126 reduced inflammation and apoptosis of diabetic nephropathy through PI3K/AKT signalling pathway by VEGF.
Diabetic Neuropathies
Diabetes-Induced Mechanical Hyperalgesia Involves Spinal Mitogen-Activated Protein Kinase Activation in Neurons and Microglia via N-Methyl-D-aspartate-Dependent Mechanisms.
Diabetic Neuropathies
Intrathecal inhibition of calcium/calmodulin-dependent protein kinase II in diabetic neuropathy adversely affects pain-related behavior.
Diabetic Neuropathies
Metabolic effect of PGE1 analogue 01206.alpha CD on nerve Na(+)-K(+)-ATPase activity of rats with streptozocin-induced diabetes is mediated via cAMP: possible role of cAMP in diabetic neuropathy.
Diabetic Neuropathies
Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model.
Diabetic Neuropathies
Real-Time Translocation and Function of PKC?II Isoform in Response to Nociceptive Signaling via the TRPV1 Pain Receptor.
Diabetic Neuropathies
The effects of intraganglionic injection of calcium/calmodulin-dependent protein kinase II inhibitors on pain-related behavior in diabetic neuropathy.
Diabetic Neuropathies
The expression of calcium/calmodulin-dependent protein kinase II in the dorsal horns of rats with type 1 and type 2 diabetes.
Diabetic Retinopathy
Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy.
Diabetic Retinopathy
Glycogen synthase kinase-3: a key kinase in retinal neuron apoptosis in early diabetic retinopathy.
Diabetic Retinopathy
RKIP negatively regulates the glucose induced angiogenesis and endothelial-mesenchymal transition in retinal endothelial cells.
Diabetic Retinopathy
Role of raf-1 kinase in diabetes-induced accelerated apoptosis of retinal capillary cells.
Diabetic Retinopathy
The role of Raf-1 kinase in diabetic retinopathy.
Diffuse Intrinsic Pontine Glioma
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.
DiGeorge Syndrome
Circadian rhythm genes in cancer: insight into their functions and regulation involving noncoding RNAs.
Digestive System Neoplasms
Serine/threonine kinase 15 gene polymorphism and risk of digestive system cancers: A meta-analysis.
Disorders of Excessive Somnolence
Clustering of motor and nonmotor traits in leucine-rich repeat kinase 2 G2019S Parkinson's disease nonparkinsonian relatives: A multicenter family study.
Disorders of Excessive Somnolence
Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease.
Distemper
Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II.
DNA Repair-Deficiency Disorders
BCR-ABL down-regulates the DNA repair protein DNA-PKcs.
DNA Repair-Deficiency Disorders
Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells.
DNA Repair-Deficiency Disorders
Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma.
DNA Virus Infections
A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus.
DNA Virus Infections
Roles of GSK-3 and ?-Catenin in Antiviral Innate Immune Sensing of Nucleic Acids.
DNA Virus Infections
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway.
Down Syndrome
Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21).
Down Syndrome
Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase.
Down Syndrome
Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.
Down Syndrome
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Down Syndrome
Decreased cyclin dependent kinase in brain of patients with Down syndrome.
Down Syndrome
Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
Down Syndrome
Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein.
Down Syndrome
DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.
Down Syndrome
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.
Down Syndrome
Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF-kappaB in brains of patients with Down syndrome.
Down Syndrome
Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes of down syndrome patients.
Down Syndrome
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Down Syndrome
Hybridization signatures during thymus ontogeny reveals modulation of genes coding for T-cell signaling proteins.
Down Syndrome
Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down syndrome.
Down Syndrome
Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.
Down Syndrome
Kinetic Properties of a MNB/DYRK1A Mutant Suitable for the Elucidation of Biochemical Pathways.
Down Syndrome
Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain.
Down Syndrome
Mnb/Dyrk1A phosphorylation regulates the interaction of dynamin 1 with SH3 domain-containing proteins.
Down Syndrome
MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins.
Down Syndrome
Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins.
Down Syndrome
Negative-feedback inhibition of NFATc1 by DYRK1A regulates bone homeostasis.
Down Syndrome
Overexpression of Dyrk1A, a Down Syndrome Candidate, Decreases Excitability and Impairs Gamma Oscillations in the Prefrontal Cortex.
Down Syndrome
Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome.
Down Syndrome
Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1).
Down Syndrome
Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry.
Down Syndrome
Regulation of Dyrk1A kinase activity by 14-3-3.
Down Syndrome
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Down Syndrome
Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.
Drug Resistant Epilepsy
The Putative Role of mTOR Inhibitors in Non-tuberous Sclerosis Complex-Related Epilepsy.
Drug Resistant Epilepsy
What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.
Drug-Related Side Effects and Adverse Reactions
A role for survivin in chemoresistance of endothelial cells mediated by VEGF.
Ductus Arteriosus, Patent
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Duodenal Neoplasms
Duodenal cancer in a young patient with Peuts-Jeghers syndrome harboring an entire deletion of the STK11 gene.
Dwarfism
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.
Dyskinesias
A common leucine-rich repeat kinase 2 gene mutation in familial and sporadic Parkinson's disease in Russia.
Dyskinesias
A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson disease.
Dyskinesias
CaMKII inhibition ameliorated levodopa-induced dyskinesia by downregulating tyrosine hydroxylase activity in an experimental model of Parkinson's disease.
Dyskinesias
Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia.
Dyskinesias
Dyskinesias in patients with Parkinson's disease: Effect of the leucine-rich repeat kinase 2 (LRRK2) G2019S mutation.
Dyskinesias
Greater improvement in LRRK2 G2019S patients undergoing Subthalamic Nucleus Deep Brain Stimulation compared to non-mutation carriers.
Dyskinesias
Interactions of CaMKII with dopamine D2 receptors: roles in levodopa-induced dyskinesia in 6-hydroxydopamine lesioned Parkinson's rats.
Dyskinesias
Is the common LRRK2 G2019S mutation related to dyskinesias in North African Parkinson disease?
Dyskinesias
LRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesias.
Dyskinesias
Olfactory heterogeneity in LRRK2 related Parkinsonism.
Dyskinesias
Parkinson's disease in the Western Pacific Region.
Dyskinesias
Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys.
Dyskinesias
Striatal leucine-rich repeat kinase 2 mRNA is increased in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned common marmosets (Callithrix jacchus) with L-3, 4-dihydroxyphenylalanine methyl ester-induced dyskinesia.
Dyskinesias
Understanding the role of glycogen synthase kinase-3 in L-DOPA-induced dyskinesia in Parkinson's disease.
Dyslipidemias
Ameliorative effect of low-dose spironolactone on obesity and insulin resistance is through replenishment of estrogen in ovariectomized rats.
Dyslipidemias
Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy.
Dyslipidemias
AMPK in the small intestine in normal and pathophysiological conditions.
Dyslipidemias
Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in prediabetic obese Zucker rats.
Dyslipidemias
Effects and potential mechanism of atorvastatin treatment on Lp-PLA2 in rats with dyslipidemia.
Dyslipidemias
Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.
Dyslipidemias
Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice.
Dysplastic Nevus Syndrome
Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas).
Dysplastic Nevus Syndrome
Outcomes of endoscopic ultrasound as a one-off pancreatic cancer screening tool for 122 high- and moderate-risk patients.
Dysplastic Nevus Syndrome
Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases.
Dystonia
A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation.
Dystonia
Clinical heterogeneity of LRRK2 p.I2012T mutation.
Dystonia
Diagnostic delay in Parkinson's disease caused by PRKN mutations.
Dystonia
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Dystonic Disorders
Analysis of the LRRK2 Gly2385Arg variant in primary dystonia and multiple system atrophy in Taiwan.
e2 ubiquitin-conjugating enzyme deficiency
Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase.
Echinococcosis
Characterization of 14-3-3 isoforms expressed in the Echinococcus granulosus pathogenic larval stage.
Echinococcosis
The Echinococcus multilocularis 14-3-3 protein protects mice against primary but not secondary alveolar echinococcosis.
Encephalitis
14-3-3 protein in CSF: an early predictor of SIV CNS disease.
Encephalitis
Anti-SARS-CoV-2 antibodies in the CSF, blood-brain barrier dysfunction, and neurological outcome: Studies in 8 stuporous and comatose patients.
Encephalitis
Differential activation of the c-Jun N-terminal kinase/stress-activated protein kinase and p38 mitogen-activated protein kinase signal transduction pathways in the mouse brain upon infection with neurovirulent influenza A virus.
Encephalitis
Effects of isoflurane on brain inflammation after subarachnoid hemorrhage in mice.
Encephalitis
Fas-mediated apoptotic signaling in the mouse brain following reovirus infection.
Encephalitis
Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection.
Encephalitis
Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase.
Encephalitis
Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction.
Encephalitis
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.
Encephalitis
Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase.
Encephalitis
Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis.
Encephalitis, Japanese
Antisense Oligonucleotides Targeting Raf-1 Block Japanese Encephalitis Virus In Vitro and In Vivo.
Encephalitis, Japanese
p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammation in Astrocytes.
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalitis, Viral
Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease.
Encephalomyelitis
Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.
Encephalomyelitis
c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis
Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis.
Encephalomyelitis
Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.
Encephalomyelitis
Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
Encephalomyelitis
RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling.
Encephalomyelitis
Role of glial 14-3-3 gamma protein in autoimmune demyelination.
Encephalomyelitis
Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.
Encephalomyelitis
Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.
Encephalomyelitis, Autoimmune, Experimental
c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.
Encephalomyelitis, Autoimmune, Experimental
Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
Encephalomyelitis, Autoimmune, Experimental
RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling.
Encephalomyelitis, Autoimmune, Experimental
Role of glial 14-3-3 gamma protein in autoimmune demyelination.
Encephalomyelitis, Autoimmune, Experimental
Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis.
Encephalopathy, Bovine Spongiform
Rationale for diagnosing human prion disease.
Encephalopathy, Bovine Spongiform
Time-course studies of 14-3-3 protein isoforms in cerebrospinal fluid and brain of primates after oral or intracerebral infection with bovine spongiform encephalopathy agent.
Encephalopathy, Bovine Spongiform
Yeast 14-3-3 proteins.
Enchondromatosis
IDH1 immunohistochemistry reactivity and mosaic IDH1 or IDH2 somatic mutations in pediatric sporadic enchondroma and enchondromatosis.
Endocrine Gland Neoplasms
Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target.
Endometrial Hyperplasia
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Hyperplasia
High level of visfatin and the activation of Akt and ERK1/2 signaling pathways are associated with endometrium malignant transformation in polycystic ovary syndrome.
Endometrial Hyperplasia
Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group.
Endometrial Neoplasms
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol.
Endometrial Neoplasms
ATM mutations as an independent prognostic factor and potential biomarker for immune checkpoint therapy in endometrial cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.
Endometrial Neoplasms
c-Jun N-terminal kinase regulates apoptosis in endometrial cancer cells.
Endometrial Neoplasms
CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells.
Endometrial Neoplasms
Cross-talk between p21-activated kinase 4 and ER? signaling triggers endometrial cancer cell proliferation.
Endometrial Neoplasms
Crosstalk between NF-kappaB/p65 and beta-catenin/TCF4/p300 signalling pathways through alterations in GSK-3beta expression during trans-differentiation of endometrial carcinoma cells.
Endometrial Neoplasms
Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma.
Endometrial Neoplasms
Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer.
Endometrial Neoplasms
Expression of phosphorylated Akt, mTOR and MAPK in type I endometrial carcinoma: clinical significance.
Endometrial Neoplasms
Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma.
Endometrial Neoplasms
Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells.
Endometrial Neoplasms
Luteinizing hormone increases human endometrial cancer cells invasiveness through activation of protein kinase A.
Endometrial Neoplasms
Metformin is associated with reduced cell proliferation in human endometrial cancer by inbibiting PI3K/AKT/mTOR signaling.
Endometrial Neoplasms
MicroRNA-135a promotes proliferation, migration, invasion and induces chemoresistance of endometrial cancer cells.
Endometrial Neoplasms
MicroRNA-200c Inhibits Epithelial-Mesenchymal Transition by Targeting the BMI-1 Gene Through the Phospho-AKT Pathway in Endometrial Carcinoma Cells In Vitro.
Endometrial Neoplasms
MiR-200a and miR-200b target PTEN to regulate the endometrial cancer cell growth in vitro.
Endometrial Neoplasms
Morphoproteomic analysis reveals an overexpressed and constitutively activated phospholipase D1-mTORC2 pathway in endometrial carcinoma.
Endometrial Neoplasms
p21-activated kinase 4 regulation of endometrial cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion.
Endometrial Neoplasms
Protein kinase C-independent stimulation of activator protein-1 and c-Jun N-terminal kinase activity in human endometrial cancer cells by the LHRH agonist triptorelin.
Endometrial Neoplasms
PTEN is involved in the signal transduction pathway of contact inhibition in endometrial cells.
Endometrial Neoplasms
PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma.
Endometrial Neoplasms
Relevance of lipogenesis and AMPK/Akt/mTOR signaling pathway in endometrial cancer.
Endometrial Neoplasms
Requirement of the Akt/{beta}-Catenin Pathway for Uterine Carcinosarcoma Genesis, Modulating E-Cadherin Expression Through the Transactivation of Slug.
Endometrial Neoplasms
[Correlations of p-AKT with PTEN, P53, HER-2 expressions in endometrial carcinoma and their relationship with patient survival].
Endometrial Neoplasms
[Effect of phorbol ester on tissue-type plasminogen activator (t-PA) secretion in endometrial carcinoma cell line in vitro]
Endometrial Neoplasms
[Effects of PD98059 and LY294002 on subcutaneous xenograft of human endometrial carcinoma in nude mice].
Endometrial Neoplasms
[shRNA-Mediated Suppression of ?-Synuclein Leading to Downregulation of p38/ERK/JNK Phosphorylation and Cell Cycle Arrest in Endometrial Cancer Cells].
Endometriosis
Analysis of the oncogene BRAF mutation and the correlation of the expression of wild-type BRAF and CREB1 in endometriosis.
Endometriosis
Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models.
Endometriosis
Dysregulation of miR-202-3p Affects Migration and Invasion of Endometrial Stromal Cells in Endometriosis via Targeting ROCK1.
Endometriosis
Effects of inhibiting the PI3K/Akt/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model.
Endometriosis
Endometrial fluid is a specific and non-invasive biological sample for protein biomarker identification in endometriosis.
Endometriosis
Expression patterns of Aurora A and B kinases, Ki-67 and the estrogen and progesterone receptors determined using an endometriosis tissue microarray model.
Endometriosis
Indoleamine 2,3-dioxygenase-1 (IDO1) enhances survival and invasiveness of endometrial stromal cells via the activation of JNK signaling pathway.
Endometriosis
Inducing malignant transformation of endometriosis in rats by long-term sustaining hyperestrogenemia and type II diabetes.
Endometriosis
Inhibition of MAPK and VEGFR by Sorafenib Controls the Progression of Endometriosis.
Endometriosis
MicroRNA-regulated pathways associated with endometriosis.
Endometriosis
Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women.
Endometriosis
Panel of Autoimmune Markers for Noninvasive Diagnosis of Minimal-Mild Endometriosis: A Multicenter Study.
Endometriosis
PI3K/AKT pathway is altered in the endometriosis patient's endometrium and presents differences according to severity stage.
Endometriosis
Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway.
Endometriosis
Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis.
Endometriosis
Protein kinase CK2 participates in estrogen-mediated endothelial progenitor cell homing to endometriotic lesions through stromal cells in a stromal cell-derived factor-1- CXCR4-dependent manner.
Endometriosis
Raf-1 levels determine the migration rate of primary endometrial stromal cells of patients with endometriosis.
Endometriosis
Raf-1, a potential therapeutic target, mediates early steps in endometriosis lesion development by endometrial epithelial and stromal cells.
Endometriosis
Regulation of P21-activated kinase-4 by progesterone and tumor necrosis factor-? in human endometrium and its increased expression in advanced-stage endometriosis.
Endometriosis
RNAi-mediated blocking of ezrin reduces migration of ectopic endometrial cells in endometriosis.
Endometriosis
The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis.
Endometriosis
Unremitting cell proliferation in the secretory phase of eutopic endometriosis: involvement of pAkt and pGSK3?.
Endotoxemia
Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia.
Endotoxemia
GSK-3?-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock.
Endotoxemia
GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat.
Endotoxemia
HIPK2 phosphorylates HDAC3 for NF-?B acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.
Endotoxemia
Human endotoxemia activates p38 MAP kinase and p42/44 MAP kinase, but not c-Jun N-terminal kinase.
Endotoxemia
LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes.
Endotoxemia
Protein kinase C delta (PKC?)-extracellular-signal regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia.
Enteritis
Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis.
Enteritis
Dietary iron deficiency impaired intestinal immune function of on-growing grass carp under the infection of Aeromonas hydrophila: Regulation of NF-?B and TOR signaling.
Enteritis
Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis.
Enteritis
The duck enteritis virus early protein, UL13, found in both nucleus and cytoplasm, influences viral replication in cell culture.
Enterocolitis, Necrotizing
A Role for cAMP and Protein Kinase A in Experimental Necrotizing Enterocolitis.
Enterocolitis, Necrotizing
ROCK1 Inhibitor Stabilizes E-cadherin and Improves Barrier Function in Experimental Necrotizing Enterocolitis.
Eosinophilia
NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKK? activation.
Ependymoma
Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.
Ependymoma
IDH1 immunohistochemistry reactivity and mosaic IDH1 or IDH2 somatic mutations in pediatric sporadic enchondroma and enchondromatosis.
Ependymoma
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Epilepsy
A novel interaction between kinase activities in regulation of cilia formation.
Epilepsy
Altered patterns of Ca2+/calmodulin-dependent protein kinase II and calcineurin immunoreactivity in the hippocampus of patients with temporal lobe epilepsy.
Epilepsy
Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.
Epilepsy
Analysis of pThr286-CaMKII and CaMKII immunohistochemistry in the hippocampus of patients with temporal lobe epilepsy.
Epilepsy
Antiepileptic action of c-Jun N-terminal kinase (JNK) inhibition in an animal model of temporal lobe epilepsy.
Epilepsy
Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target.
Epilepsy
Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.
Epilepsy
Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.
Epilepsy
Aurora-A site specificity: a study with synthetic peptide substrates.
Epilepsy
Bi-directional genetic modulation of GSK-3? exacerbates hippocampal neuropathology in experimental status epilepticus.
Epilepsy
Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability.
Epilepsy
Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.
Epilepsy
CK2 Inhibition Prior to Status Epilepticus Persistently Enhances KCa2 Function in CA1 Which Slows Down Disease Progression.
Epilepsy
Control of neuronal excitability by GSK-3beta: Epilepsy and beyond.
Epilepsy
Emerging role of CaMKII in neuropsychiatric disease.
Epilepsy
Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats.
Epilepsy
Glucosamine promotes seizure activity via activation of the PI3K/Akt pathway in epileptic rats.
Epilepsy
GSK3? and Tau Protein in Alzheimer's Disease and Epilepsy.
Epilepsy
Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy.
Epilepsy
Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons.
Epilepsy
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy.
Epilepsy
Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
Epilepsy
Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy.
Epilepsy
microRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy.
Epilepsy
Mitotic DNA damage targets the Aurora A/TPX2 complex.
Epilepsy
mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy.
Epilepsy
Oral administration of the casein kinase 2 inhibitor TBB leads to persistent KCa2.2 channel up-regulation in the epileptic CA1 area and cortex, but lacks anti-seizure efficacy in the pilocarpine epilepsy model.
Epilepsy
Pathogenic MAST3 Variants in the STK Domain Are Associated with Epilepsy.
Epilepsy
Pathological tau tangles localize to focal cortical dysplasia in older patients.
Epilepsy
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy.
Epilepsy
PI3K, mTOR and GSK3 modulate cytokines' production in peripheral leukocyte in temporal lobe epilepsy.
Epilepsy
Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination.
Epilepsy
Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis.
Epilepsy
Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
Epilepsy
Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy.
Epilepsy
Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders.
Epilepsy
The c-Jun N-terminal kinase signaling pathway in epilepsy: activation, regulation, and therapeutics.
Epilepsy
The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis.
Epilepsy
The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.
Epilepsy
The Putative Role of mTOR Inhibitors in Non-tuberous Sclerosis Complex-Related Epilepsy.
Epilepsy
Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.
Epilepsy
Uncovering the Pharmacological Mechanism of Chaibei Zhixian Decoction on Epilepsy by Network Pharmacology Analysis.
Epilepsy
Unravelling the Role of Glycogen Synthase Kinase-3 in Alzheimer's Disease-Related Epileptic Seizures.
Epilepsy, Generalized
Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes.
Epilepsy, Temporal Lobe
Altered patterns of Ca2+/calmodulin-dependent protein kinase II and calcineurin immunoreactivity in the hippocampus of patients with temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Analysis of pThr286-CaMKII and CaMKII immunohistochemistry in the hippocampus of patients with temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Antiepileptic action of c-Jun N-terminal kinase (JNK) inhibition in an animal model of temporal lobe epilepsy.
Epilepsy, Temporal Lobe
GSK3? and Tau Protein in Alzheimer's Disease and Epilepsy.
Epilepsy, Temporal Lobe
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy.
Epiretinal Membrane
MicroRNA-29b participates in the epithelial-mesenchymal transition of retinal pigment epithelial cells through p-p65.
Epstein-Barr Virus Infections
Characterization of Epstein-Barr virus (EBV) BZLF1 gene promoter variants and comparison of cellular gene expression profiles in Japanese patients with infectious mononucleosis, chronic active EBV infection, and EBV-associated hemophagocytic lymphohistiocytosis.
Epstein-Barr Virus Infections
Latent membrane protein 1 of Epstein-Barr virus regulates death-associated protein kinase 1 in lymphoblastoid cell line.
Epstein-Barr Virus Infections
Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity.
Epstein-Barr Virus Infections
Post-transplant lymphoproliferative disorders. Molecular analysis of histogenesis and pathogenesis.
Escherichia coli Infections
cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis.
Esophageal Neoplasms
APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model.
Esophageal Neoplasms
Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines.
Esophageal Neoplasms
Clinical significance of 14-3-3 zeta in human esophageal cancer.
Esophageal Neoplasms
Correlation between the protein expression levels of A-kinase anchor protein95, p-retinoblastoma (Ser780), cyclin D2/3, and cyclin E2 in esophageal cancer tissues.
Esophageal Neoplasms
Cross-signaling among phosphinositide-3 kinase, mitogen-activated protein kinase and sonic hedgehog pathways exists in esophageal cancer.
Esophageal Neoplasms
CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer.
Esophageal Neoplasms
DNA-PKcs expression in esophageal cancer as a predictor for chemoradiation therapeutic sensitivity.
Esophageal Neoplasms
Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase.
Esophageal Neoplasms
Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.
Esophageal Neoplasms
High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis.
Esophageal Neoplasms
Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells.
Esophageal Neoplasms
Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer.
Esophageal Neoplasms
Lithium inhibits proliferation of human esophageal cancer cell line Eca-109 by inducing a G2/M cell cycle arrest.
Esophageal Neoplasms
Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-?-inducible protein 10 in a casein kinase 2-dependent manner.
Esophageal Neoplasms
Phorbol 12,13 dibutyrate behaves in a tumor-inhibitory manner in esophageal adenocarcinoma cell lines.
Esophageal Neoplasms
Raf kinase inhibitor protein inhibits esophageal cancer cell invasion through downregulation of matrix metalloproteinase expression.
Esophageal Neoplasms
Role of Human papilloma virus Infection and Altered Methylation of Specific Genes in Esophageal Cancer.
Esophageal Neoplasms
Silencing of ribosomal protein L34 (RPL34) inhibits the proliferation and invasion of esophageal cancer cells.
Esophageal Neoplasms
Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway.
Esophageal Neoplasms
The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development.
Esophageal Squamous Cell Carcinoma
Associations of ATM Polymorphisms With Survival in Advanced Esophageal Squamous Cell Carcinoma Patients Receiving Radiation Therapy.
Esophageal Squamous Cell Carcinoma
c-erbB-2 oncoprotein expression related to chemoradioresistance in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Decreased expression and aberrant methylation of Raf kinase inhibitory protein gene in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.
Esophageal Squamous Cell Carcinoma
Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis.
Esophageal Squamous Cell Carcinoma
Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance.
Esophageal Squamous Cell Carcinoma
HIPK2 inhibits cell metastasis and improves chemosensitivity in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Inhibition of glycogen synthase kinase 3 beta (GSK3?) suppresses the progression of esophageal squamous cell carcinoma by modifying STAT3 activity.
Esophageal Squamous Cell Carcinoma
Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells.
Esophageal Squamous Cell Carcinoma
LncRNA EGFR-AS1 Upregulates ROCK1 by Sponging miR-145 to Promote Esophageal Squamous Cell Carcinoma Cell Invasion and Migration.
Esophageal Squamous Cell Carcinoma
Metformin inhibits the migration and invasion of esophageal squamous cell carcinoma cells by downregulating the protein kinase B signaling pathway.
Esophageal Squamous Cell Carcinoma
Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
p21-activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1.
Esophageal Squamous Cell Carcinoma
Prognostic Value of Raf Kinase Inhibitor Protein in Esophageal Squamous Cell Carcinoma.
Esophageal Squamous Cell Carcinoma
Promoter methylation and expression of Raf kinase inhibitory protein in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
RUNX3 reverses cisplatin resistance in esophageal squamous cell carcinoma via suppression of the protein kinase B pathway.
Esophageal Squamous Cell Carcinoma
Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma.
Esophageal Squamous Cell Carcinoma
[Relationship between ROCK2 expression and clinicopathologic characteristics of esophageal squamous cell carcinoma].
Esophagitis
Role of Human papilloma virus Infection and Altered Methylation of Specific Genes in Esophageal Cancer.
Essential Hypertension
Association of Ala589Ser polymorphism of WNK4 gene with essential hypertension in a high-risk Chinese population.
Essential Hypertension
Association of with-no-lysine kinase 1 and Serine/Threonine kinase 39 gene polymorphisms and haplotypes with essential hypertension in Tibetans.
Essential Hypertension
Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.
Essential Hypertension
WNK4 intron 10 polymorphism is not associated with hypertension.
Essential Hypertension
[Protein kinase A and C activity of erythrocytes in patients with essential hypertension]
Essential Tremor
Analysis of LRRK2 functional domains in nondominant Parkinson disease.
Essential Tremor
Case-control analysis of LRRK2 protective variants in Essential Tremor.
Essential Tremor
Common mutations in the LRRK2 exon 41 are not responsible for essential tremor in Italian patients.
Essential Tremor
Essential tremor and the common LRRK2 G2385R variant.
Essential Tremor
Genetic Analysis of LRRK1 and LRRK2 Variants in Essential Tremor Patients.
Essential Tremor
Genetic analysis of LRRK2 P755L variant in Caucasian patients with Parkinson's disease.
Essential Tremor
Genome-wide association study in essential tremor identifies three new loci.
Essential Tremor
Lrrk2 R1628P variant is a risk factor for essential tremor.
Essential Tremor
The LRRK2 I2012T, G2019S and I2020T mutations are not common in patients with essential tremor.
Extranodal Extension
Cytoplasmic accumulation of glycogen synthase kinase-3beta is associated with aggressive clinicopathological features in human prostate cancer.
Eye Diseases
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Eye Diseases
MiR-2964a-5p binding site SNP regulates
Eye Diseases
Phosphoinositide-3-kinase ? inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells.
Familial Mediterranean Fever
A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.
Fanconi Anemia
A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA.
Fanconi Anemia
Aurora A kinase is required for activation of the Fanconi anemia/BRCA pathway upon DNA damage.
Fanconi Anemia
Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.
Fanconi Anemia
FANCM-FAAP24 and HCLK2: roles in ATR signalling and the Fanconi anemia pathway.
Fanconi Anemia
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
Fanconi Anemia
Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion.
Fanconi Anemia
Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes.
Fanconi Anemia
The p38 pathway partially mediates caspase-3 activation induced by reactive oxygen species in Fanconi anemia C cells.
Fatty Liver
Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis.
Fatty Liver
Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease.
Fatty Liver
CKIP-1 augments autophagy in steatotic hepatocytes by inhibiting Akt/mTOR signal pathway.
Fatty Liver
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance.
Fatty Liver
Effects of different therapeutic methods and typical recipes of Chinese medicine on activation of c-Jun N-terminal Kinase in Kupffer cells of rats with fatty liver disease.
Fatty Liver
Efficacy of Cigu Xiaozhi pill on non-alcoholic steatohepatitis-associated lipoapoptosis through stress-activated c-Jun N-terminal kinase signalling pathway.
Fatty Liver
Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
Fatty Liver
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver.
Fatty Liver
JNK signaling pathway in metabolic disorders: An emerging therapeutic target.
Fatty Liver
JNK1 but not JNK2 promotes the development of steatohepatitis in mice.
Fatty Liver
LRRK2 Regulates CPT1A to Promote ?-Oxidation in HepG2 Cells.
Fatty Liver
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Fatty Liver
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle.
Fatty Liver
p38? MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure.
Fatty Liver
Protective effects of SP600125 in a diet-induced rat model of non-alcoholic steatohepatitis.
Fatty Liver
Protein kinase A regulatory subunits in human adipose tissue: decreased R2B expression and activity in adipocytes from obese subjects.
Fatty Liver
Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans.
Fatty Liver
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.
Fatty Liver
The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome.
Fatty Liver
The ménage à trois of autophagy, lipid droplets and liver disease.
Fetal Alcohol Spectrum Disorders
Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginyl-beta-hydroxylase expression.
Fetal Alcohol Spectrum Disorders
Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain.
Fetal Diseases
A developmental role for ataxia-telangiectasia mutated in protecting the embryo from spontaneous and phenytoin-enhanced embryopathies in culture.
Fetal Growth Retardation
Antenatal Taurine Improves Intrauterine Growth-Restricted Fetal Rat Brain Development Which Is Associated with Increasing the Activity of PKA-CaMKII/c-fos Signal Pathway.
Fetal Growth Retardation
Dietary Methionine Restriction Alleviates Hyperglycemia in Pigs with Intrauterine Growth Restriction by Enhancing Hepatic Protein Kinase B Signaling and Glycogen Synthesis.
Fetal Growth Retardation
Inhibition of decidual IGF-1 signaling in response to hypoxia and leucine deprivation is mediated by mTOR and AAR pathways and increased IGFBP-1 phosphorylation.
Fetal Growth Retardation
Liver mTOR Controls IGF-I Bioavailability by Regulation of Protein Kinase CK2 and IGFBP-1 Phosphorylation in Fetal Growth Restriction.
Fetal Growth Retardation
[Effects of prenatal taurine on mRNA expression of PKA CREB signal pathway and glial cell line derived neurotrophic factor in fetal rat brains of intrauterine growth restriction]
Fibroma
14-3-3 sigma is a useful immunohistochemical marker for diagnosing ovarian granulosa cell tumors and steroid cell tumors.
Fibroma
Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors?
Fibroma
Superficial fibromatoses are genetically distinct from deep fibromatoses.
Fibromatosis, Aggressive
Clinical significance of midkine expression in sporadic desmoid tumors.
Fibromatosis, Aggressive
Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis.
Fibromatosis, Aggressive
Signal transduction pathway analysis in fibromatosis: receptor and nonreceptor tyrosine kinases.
Fibrosarcoma
A quantitative single-cell assay for protein kinase B reveals important insights into the biochemical behavior of an intracellular substrate peptide.
Fibrosarcoma
Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults.
Fibrosarcoma
Alpinia officinarum Stimulates Osteoblast Mineralization and Inhibits Osteoclast Differentiation.
Fibrosarcoma
Anthocyanins Promote Learning through Modulation of Synaptic Plasticity Related Proteins in an Animal Model of Ageing.
Fibrosarcoma
Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway.
Fibrosarcoma
BRAF and MEK Inhibitors: Use and Resistance in BRAF-Mutated Cancers.
Fibrosarcoma
Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers.
Fibrosarcoma
Decoding the Role of CD271 in Melanoma.
Fibrosarcoma
Dimerization-induced allostery in protein kinase regulation.
Fibrosarcoma
Epidermal growth factor regulates protein kinase A activity in murine fibrosarcoma cells: differences between metastatic and nonmetastatic tumor cell variants.
Fibrosarcoma
Establishment of an induced pluripotent stem cell line from a Noonan syndrome patient with the heterozygote mutation p.S257L (c.770C > T) in RAF1 gene.
Fibrosarcoma
Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.
Fibrosarcoma
Human Epidermal Growth Factor Receptor-2 Promotes Invasion and Metastasis in Gastric Cancer by Activating Mitogen-activated Protein Kinase Signaling.
Fibrosarcoma
Hyaluronidase activation of c-Jun N-terminal kinase is necessary for protection of L929 fibrosarcoma cells from staurosporine-mediated cell death.
Fibrosarcoma
Identification of genes responsible for cell migration by a library of randomized ribozymes.
Fibrosarcoma
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.
Fibrosarcoma
Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent.
Fibrosarcoma
S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo.
Fibrosarcoma
Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways.
Fibrosarcoma
Tenascin-C signaling through induction of 14-3-3 tau.
Fibrosarcoma
TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway.
Fibrous Dysplasia, Polyostotic
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
Fibrous Dysplasia, Polyostotic
Molecular genetic advances in pituitary tumor development.
Fibrous Dysplasia, Polyostotic
Molecular genetics of adrenocortical tumor formation and potential pharmacologic targets.
Fragile X Syndrome
Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.
Fragile X Syndrome
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Fragile X Syndrome
Glycogen synthase kinase-3: a promising therapeutic target for fragile x syndrome.
Fragile X Syndrome
Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome.
Fragile X Syndrome
Selective inhibition of glycogen synthase kinase 3? corrects pathophysiology in a mouse model of fragile X syndrome.
Fragile X Syndrome
Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice.
Fragile X Syndrome
The role of glycogen synthase kinase-3 signaling in neurodevelopment and fragile X syndrome.
Friedreich Ataxia
Up-regulation of c-Jun N-terminal kinase pathway in Friedreich's ataxia cells.
Frontotemporal Dementia
A mouse model to study tau pathology related with tau phosphorylation and assembly.
Frontotemporal Dementia
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Frontotemporal Dementia
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.
Frontotemporal Dementia
Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease.
Frontotemporal Dementia
Clinical heterogeneity of LRRK2 p.I2012T mutation.
Frontotemporal Dementia
Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration.
Frontotemporal Dementia
DAPK1 is Associated with FTD and not with Alzheimer's Disease.
Frontotemporal Dementia
Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3beta identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes.
Frontotemporal Dementia
Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.
Frontotemporal Dementia
How many biomarkers to discriminate neurodegenerative dementia?
Frontotemporal Dementia
Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation.
Frontotemporal Dementia
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Frontotemporal Dementia
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Frontotemporal Dementia
Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.
Frontotemporal Dementia
Serine-409 phosphorylation and oxidative damage define aggregation of human protein tau in yeast.
Frontotemporal Dementia
Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.
Frontotemporal Dementia
[Alzheimer disease and tau protein].
Frontotemporal Lobar Degeneration
Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures.
Frontotemporal Lobar Degeneration
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Frontotemporal Lobar Degeneration
Investigation of C9orf72 in 4 Neurodegenerative Disorders.
Frontotemporal Lobar Degeneration
LRRK2 and neurodegeneration.
Frontotemporal Lobar Degeneration
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Frontotemporal Lobar Degeneration
PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies.
Frontotemporal Lobar Degeneration
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Frontotemporal Lobar Degeneration
SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation.
Gallbladder Neoplasms
Circular RNA HIPK3 promotes gallbladder cancer cell growth by sponging microRNA-124.
Gallbladder Neoplasms
Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes.
Gallstones
Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes.
Ganglioglioma
Molecular genetic analysis in a case of ganglioglioma: identification of a new mutation.
Ganglion Cysts
Activation of the RAS/B-RAF-MEK-ERK pathway in satellite glial cells contributes to substance p-mediated orofacial pain.
Ganglion Cysts
The role of Efr3a in age-related hearing loss.
Ganglion Cysts
[Role of transient receptor potential melastatin 8 channels in migraine mechanism in rats].
Ganglioneuroma
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Ganglioneuroma
Targeting ganglioneuromas with mTOR inhibitors.
Gastritis
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
Gastritis
Inhibition of phosphoinositide 3-kinase/Akt pathway decreases hypoxia inducible factor-1? expression and increases therapeutic efficacy of paclitaxel in human hypoxic gastric cancer cells.
Gastroenteritis
Viral strategies for triggering and manipulating mitophagy.
Gastrointestinal Neoplasms
c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer.
Gastrointestinal Neoplasms
Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.
Gastrointestinal Neoplasms
Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay.
Gastrointestinal Neoplasms
Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis.
Gastrointestinal Neoplasms
Emerging Therapeutic Implications of STK11 Mutation: Case Series.
Gastrointestinal Neoplasms
Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability.
Gastrointestinal Neoplasms
Glycogen synthase kinase-3 beta regulates Snail and ?-catenin expression during Fas-induced epithelial-mesenchymal transition in gastrointestinal cancer.
Gastrointestinal Neoplasms
Identification of XAF1 as a novel cell cycle regulator through modulating G(2)/M checkpoint and interaction with checkpoint kinase 1 in gastrointestinal cancer.
Gastrointestinal Neoplasms
Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.
Gastrointestinal Neoplasms
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Gastrointestinal Neoplasms
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Gastrointestinal Neoplasms
Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold.
Gastrointestinal Neoplasms
The clinical implication of 14-3-3 sigma expression in primary gastrointestinal malignancy.
Gastrointestinal Neoplasms
The MK2 pathway is linked to G-CSF, cytokine production and metastasis in gastric cancer: a novel intercorrelation analysis approach.
Gastrointestinal Stromal Tumors
Clinical and prognostic significance of Raf kinase inhibitory protein expression in gastrointestinal stromal tumors.
Gastrointestinal Stromal Tumors
Common genetic changes in leiomyosarcoma and gastrointestinal stromal tumour: implication for ataxia telangiectasia mutated involvement.
Gastrointestinal Stromal Tumors
Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients.
Gastrointestinal Stromal Tumors
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Gastrointestinal Stromal Tumors
Multiple primary malignant neoplasms: A case report and literature review.
Gastrointestinal Stromal Tumors
Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines.
Gastroparesis
Reactive oxygen species overproduction and MAP kinase phosphatase-1 degradation are associated with gastroparesis in a streptozotocin-induced male diabetic rat model.
Gaucher Disease
Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature.
Genetic Diseases, Inborn
24 targeted disruption of ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer.
Genetic Diseases, Inborn
A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.
Genetic Diseases, Inborn
A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes.
Genetic Diseases, Inborn
Alteration of the ATM gene occurs in gastric cancer cell lines and primary tumors associated with cellular response to DNA damage.
Genetic Diseases, Inborn
Analysis of trinucleotide repeats in myotonic dystrophy.
Genetic Diseases, Inborn
Assaying for Radioresistant DNA Synthesis, the Hallmark Feature of the Intra-S-Phase Checkpoint Using a DNA Fiber Technique.
Genetic Diseases, Inborn
Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra.
Genetic Diseases, Inborn
ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence?
Genetic Diseases, Inborn
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.
Genetic Diseases, Inborn
ATM: the product of the gene mutated in ataxia-telangiectasia.
Genetic Diseases, Inborn
Brain and induced pluripotent stem cell-derived neural stem cells as an in vitro model of neurodegeneration in ataxia-telangiectasia.
Genetic Diseases, Inborn
Detecting ATM-dependent chromatin modification in DNA damage response.
Genetic Diseases, Inborn
Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.
Genetic Diseases, Inborn
Effect of age and affection status on blood pressure, serum potassium and stature in familial hyperkalaemia and hypertension.
Genetic Diseases, Inborn
Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex.
Genetic Diseases, Inborn
Genetic risks and familial associations of small bowel carcinoma.
Genetic Diseases, Inborn
Human microcephaly.
Genetic Diseases, Inborn
Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype.
Genetic Diseases, Inborn
Non-Hodgkin B-cell Lymphoma of the Ovary in a Child with Ataxia-Telangiectasia.
Genetic Diseases, Inborn
Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity.
Genetic Diseases, Inborn
Rapid screen for truncating ATM mutations by PTT-ELISA.
Genetic Diseases, Inborn
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.
Genetic Diseases, Inborn
Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia.
Gestational Trophoblastic Disease
Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma.
Gestational Trophoblastic Disease
p21-Activated Kinase-1 Promotes Aggressive Phenotype, Cell Proliferation, and Invasion in Gestational Trophoblastic Disease.
Giant Cell Arteritis
Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.
Glaucoma
Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma.
Glaucoma
c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis.
Glaucoma
Expression of 14-3-3 Zeta Protein in Dexamethasone-Treated Mice and Human TM-1 Cells.
Glaucoma
Expression of phosphorylated c-Jun N-terminal protein kinase (JNK) in experimental glaucoma in rats.
Glaucoma
GLC1A mutations point to regions of potential functional importance on the TIGR/MYOC protein.
Glaucoma
Increased DNA breaks and up-regulation of both G(1) and G(2) checkpoint genes p21(WAF1/CIP1) and 14-3-3 sigma in circulating leukocytes of glaucoma patients and vasospastic individuals.
Glaucoma
Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma.
Glaucoma
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells.
Glaucoma
Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathway.
Glaucoma
Protective effect of a JNK inhibitor against retinal ganglion cell loss induced by acute moderate ocular hypertension.
Glaucoma
Ripasudil alleviated the inflammation of RPE cells by targeting the miR-136-5p/ROCK/NLRP3 pathway.
Glaucoma
Structure-based design of small molecule and peptide inhibitors for selective targeting of ROCK1: an integrative computational approach.
Glaucoma
The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling.
Glioblastoma
14-3-3 eta depletion sensitizes glioblastoma cells to irradiation due to enhanced mitotic cell death.
Glioblastoma
2-Aminophenoxazine-3-one-induced apoptosis via generation of reactive oxygen species followed by c-jun N-terminal kinase activation in the human glioblastoma cell line LN229.
Glioblastoma
5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
Glioblastoma
?-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells.
Glioblastoma
A case of an epithelioid glioblastoma with the BRAF V600E mutation colocalized with BRAF intact low-grade diffuse astrocytoma.
Glioblastoma
A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications.
Glioblastoma
A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes.
Glioblastoma
A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.
Glioblastoma
A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status.
Glioblastoma
Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells.
Glioblastoma
Activation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) with Lidocaine Provokes Pyroptosis of Glioblastoma Cells.
Glioblastoma
Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells.
Glioblastoma
Advanced Molecular Characterization Using Digital Spatial Profiling Technology on Immunooncology Targets in Methylated Compared with Unmethylated IDH-Wildtype Glioblastoma.
Glioblastoma
Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma.
Glioblastoma
AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastoma.
Glioblastoma
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Glioblastoma
An Experimenter's Guide to Glioblastoma Invasion Pathways.
Glioblastoma
AnvirzelTMregulates cell death through inhibiting GSK-3 activity in human U87 glioma cells.
Glioblastoma
AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors.
Glioblastoma
Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.
Glioblastoma
Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.
Glioblastoma
Aurora kinase inhibitors as anti-cancer therapy.
Glioblastoma
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Glioblastoma
Bifunctional effects of a protein kinase inhibitor (H-7) on heat-induced p53-dependent WAF1 accumulation.
Glioblastoma
BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells.
Glioblastoma
c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells.
Glioblastoma
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Glioblastoma
Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival.
Glioblastoma
Casein Kinase 2: a novel player in glioblastoma therapy and cancer stem cells.
Glioblastoma
Casein kinase 2? regulates glioblastoma brain tumor-initiating cell growth through the ?-catenin pathway.
Glioblastoma
Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells.
Glioblastoma
Combination Treatment with PPAR? Ligand and Its Specific Inhibitor GW9662 Downregulates BIS and 14-3-3 Gamma, Inhibiting Stem-Like Properties in Glioblastoma Cells.
Glioblastoma
Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models.
Glioblastoma
Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells.
Glioblastoma
Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models.
Glioblastoma
Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential.
Glioblastoma
Constitutive CHK1 expression drives a pSTAT3-CIP2A circuit that promotes glioblastoma cell survival and growth.
Glioblastoma
Correction to: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.
Glioblastoma
CREB regulates AChE-R-induced proliferation of human glioblastoma cells.
Glioblastoma
CRM197 in Combination With shRNA Interference of VCAM-1 Displays Enhanced Inhibitory Effects on Human Glioblastoma Cells.
Glioblastoma
CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.
Glioblastoma
CRN2 enhances the invasiveness of glioblastoma cells.
Glioblastoma
D11-Mediated Inhibition of Protein Kinase CK2 Impairs HIF-1?-Mediated Signaling in Human Glioblastoma Cells.
Glioblastoma
DDR1 (discoidin domain receptor tyrosine kinase 1) drives glioblastoma therapy resistance by modulating autophagy.
Glioblastoma
Differential sensitivity of human glioblastoma LN18 (PTEN-positive) and A172 (PTEN-negative) cells to Taxol for apoptosis.
Glioblastoma
DMC is not better than TMZ on intracranial anti-glioma effects.
Glioblastoma
DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation.
Glioblastoma
DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR1.
Glioblastoma
Down-regulation of 14-3-3 zeta sensitizes human glioblastoma cells to apoptosis induction.
Glioblastoma
Downregulation of protein kinase CK2 induces autophagic cell death through modulation of the mTOR and MAPK signaling pathways in human glioblastoma cells.
Glioblastoma
Effects of Glycogen Synthase Kinase Inhibitor on Glioblastoma Multiforme Cell Line via Apoptosis and Cell Signaling Pathways.
Glioblastoma
Effects of protein kinase inhibitors on heat-induced hsp72 gene expression in a human glioblastoma cell line.
Glioblastoma
Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis.
Glioblastoma
ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status.
Glioblastoma
Enhancement of DNA double-strand break induction and cell killing by K-shell absorption of phosphorus in human cell lines.
Glioblastoma
Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation.
Glioblastoma
Expression of the zinc importer protein ZIP9/SLC39A9 in glioblastoma cells affects phosphorylation states of p53 and GSK-3? and causes increased cell migration.
Glioblastoma
Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas.
Glioblastoma
Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation.
Glioblastoma
Genistein sensitizes glioblastoma cells to carbon ions via inhibiting DNA-PKcs phosphorylation and subsequently repressing NHEJ and delaying HR repair pathways.
Glioblastoma
Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution.
Glioblastoma
Glioblastoma multiforme: the role of DSB repair between genotype and phenotype.
Glioblastoma
Glycogen synthase kinase 3? inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling.
Glioblastoma
Glycogen synthase kinase-3 inhibition in glioblastoma multiforme cells induces apoptosis, cell cycle arrest and changing biomolecular structure.
Glioblastoma
Glycogen synthase kinase-3beta regulates astrocytic differentiation of U87-MG human glioblastoma cells.
Glioblastoma
GSK3beta regulates differentiation and growth arrest in glioblastoma.
Glioblastoma
High resistance to X-rays and therapeutic carbon ions in glioblastoma cells bearing dysfunctional ATM associates with intrinsic chromosomal instability.
Glioblastoma
Histone deacetylase 1 promotes glioblastoma cell proliferation and invasion via activation of PI3K/AKT and MEK/ERK signaling pathways.
Glioblastoma
Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1.
Glioblastoma
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
Glioblastoma
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay.
Glioblastoma
ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1.
Glioblastoma
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Glioblastoma
Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy.
Glioblastoma
Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice.
Glioblastoma
Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells.
Glioblastoma
Inhibition of Casein Kinase II by CX-4945, But Not Yes-associated protein (YAP) by Verteporfin, Enhances the Antitumor Efficacy of Temozolomide in Glioblastoma.
Glioblastoma
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
Glioblastoma
Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma.
Glioblastoma
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy.
Glioblastoma
Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs.
Glioblastoma
Interplay of VEGFa and MMP2 regulates invasion of glioblastoma.
Glioblastoma
Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels.
Glioblastoma
Knockdown of checkpoint kinase 1 is associated with the increased radiosensitivity of glioblastoma stem-like cells.
Glioblastoma
Lensoside A? as an Adjuvant to the Anti-Glioma Potential of Sorafenib.
Glioblastoma
LncRNA RP11-390F4.3 inhibits invasion and migration of glioblastoma cells by downregulating ROCK1.
Glioblastoma
LncRNA XIST regulates cell proliferation, migration and invasion of glioblastoma via regulating miR-448 and ROCK1.
Glioblastoma
LY294002 induces differentiation and inhibits invasion of glioblastoma cells by targeting GSK-3beta and MMP.
Glioblastoma
Macrophage migration inhibitory factor enhances autophagy by regulating ROCK1 activity and contributes to the escape of dendritic cell surveillance in glioblastoma.
Glioblastoma
Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells.
Glioblastoma
Mesenchymal subtype of glioblastomas with high DNA-PKcs expression is associated with better response to radiotherapy and temozolomide.
Glioblastoma
MicroRNA-149 inhibits proliferation and invasion of glioma cells via blockade of AKT1 signaling.
Glioblastoma
MicroRNA-300 inhibited glioblastoma progression through ROCK1.
Glioblastoma
MiR-10b decreases sensitivity of glioblastoma cells to radiation by targeting AKT.
Glioblastoma
miR-19a/b promote EMT and proliferation in glioma cells via SEPT7-AKT-NF-?B pathway.
Glioblastoma
MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated.
Glioblastoma
Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma.
Glioblastoma
Multiple forms of protein kinase from normal human brain and glioblastoma.
Glioblastoma
Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas.
Glioblastoma
Novel alternatives to extracellular vesicle-based immunotherapy - exosome mimetics derived from natural killer cells.
Glioblastoma
Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example.
Glioblastoma
Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter.
Glioblastoma
Opposing Signaling of ROCK1 and ROCK2 Determines the Switching of Substrate Specificity and the Mode of Migration of Glioblastoma Cells.
Glioblastoma
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Glioblastoma
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
Glioblastoma
p27Kip1 is required for PTEN-induced G1 growth arrest.
Glioblastoma
Participation of DNA-PKcs in DSB repair after exposure to high- and low-LET radiation.
Glioblastoma
Phase 1/2 trial of temsirolimus and sorafenib in the treatment of patients with recurrent glioblastoma: North Central Cancer Treatment Group Study/Alliance N0572.
Glioblastoma
Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme.
Glioblastoma
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways.
Glioblastoma
Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma.
Glioblastoma
Phosphorylation of AKT induced by phosphorylated Hsp27 confers the apoptosis-resistance in t-AUCB-treated glioblastoma cells in vitro.
Glioblastoma
Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells.
Glioblastoma
Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma.
Glioblastoma
Protein Kinase A Distribution Differentiates Human Glioblastoma from Brain Tissue.
Glioblastoma
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Glioblastoma
Protein Kinase CK2 Content in GL261 Mouse Glioblastoma.
Glioblastoma
Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells.
Glioblastoma
Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage.
Glioblastoma
Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation.
Glioblastoma
Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro.
Glioblastoma
Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration.
Glioblastoma
Proximal promoter of the rat brain creatine kinase gene lacks a consensus CRE element but is essential for the cAMP-mediated increased transcription in glioblastoma cells.
Glioblastoma
PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an mTORC1/2 inhibitor.
Glioblastoma
PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3? and PTP1B in situ.
Glioblastoma
Puerarin inhibits proliferation and induces apoptosis in human glioblastoma cell lines.
Glioblastoma
Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma.
Glioblastoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Glioblastoma
Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme.
Glioblastoma
Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells.
Glioblastoma
Retinoic acid-induced apoptotic pathway in T-cell lymphoma: Identification of four groups of genes with differential biological functions.
Glioblastoma
RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death.
Glioblastoma
RNA Interference-Mediated Aurora Kinase A Gene Silencing Inhibits Human Glioma Cells Proliferation and Tumor Growth in Mice.
Glioblastoma
Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism.
Glioblastoma
Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma.
Glioblastoma
Serine/threonine kinase BUB1 promotes proliferation and radio-resistance in glioblastoma.
Glioblastoma
Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma.
Glioblastoma
Sorafenib tosylate as a radiosensitizer in malignant astrocytoma.
Glioblastoma
Sortilin promotes glioblastoma invasion and mesenchymal transition through GSK-3?/?-catenin/twist pathway.
Glioblastoma
Structure-based grafting and identification of kinase-inhibitors to target mTOR signaling pathway as potential therapeutics for glioblastoma.
Glioblastoma
Suppression of CaMKII? Inhibits ANO1-Mediated Glioblastoma Progression.
Glioblastoma
Targeting Protein Kinase CK2 Suppresses Pro-survival Signaling Pathways and Growth of Glioblastoma.
Glioblastoma
Targeting Protein Kinase CK2: Evaluating CX-4945 Potential for GL261 Glioblastoma Therapy in Immunocompetent Mice.
Glioblastoma
Targeting the Regulatory Subunit R2Alpha of Protein Kinase A in Human Glioblastoma through shRNA-Expressing Lentiviral Vectors.
Glioblastoma
Tenascin-C signaling through induction of 14-3-3 tau.
Glioblastoma
The Aurora A F31I polymorphism is not a risk factor for glioblastoma.
Glioblastoma
The Critical Role of SRPK1 in EMT of Human Glioblastoma in the Spinal Cord.
Glioblastoma
The efficacy and toxicity of ATM inhibition in glioblastoma initiating cells-driven tumor models.
Glioblastoma
The Role of Protein Kinase B Signaling Pathway in Anti-Cancer Effect of Rolipram on Glioblastoma Multiforme: An In Vitro Study.
Glioblastoma
The role of protein kinase CK2 in glioblastoma development.
Glioblastoma
Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells.
Glioblastoma
Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.
Glioblastoma
Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling.
Glioblastoma
Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-? receptor I kinase inhibitor LY2109761.
Glioblastoma
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.
Glioblastoma
WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.
Glioblastoma
Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells.
Glioma
2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1).
Glioma
A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.
Glioma
A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma.
Glioma
A-kinase interacting protein 1 is sufficiently expressed and positively associates with WHO grade, meanwhile predicts unfavorable overall survival independently in glioma patients.
Glioma
Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells.
Glioma
Activation of Ca2+/calmodulin-dependent protein kinase II by stimulation with bradykinin in neuroblastoma x glioma hybrid NG108-15 cells.
Glioma
Activation of the anti-apoptotic Akt/protein kinase B pathway in human malignant gliomas in vivo.
Glioma
Additive effect on survival of Raf kinase inhibitor protein and signal transducer and activator of transcription 3 in high-grade glioma.
Glioma
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Glioma
AKT Axis, miR-21, and RECK Play Pivotal Roles in Dihydroartemisinin Killing Malignant Glioma Cells.
Glioma
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.
Glioma
AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastoma.
Glioma
An E3 Ubiquitin Ligase RNF139 Serves as a Tumor-Suppressor in Glioma.
Glioma
AnvirzelTMregulates cell death through inhibiting GSK-3 activity in human U87 glioma cells.
Glioma
Apoptosis-inducing effect of myxoma virus on human neuroglioma cell lines.
Glioma
AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors.
Glioma
Association between ATM polymorphisms and cancer risk: a meta-analysis.
Glioma
Association of increased phosphatidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas.
Glioma
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
Glioma
ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data.
Glioma
Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.
Glioma
Autophagy flux inhibition, G2/M cell cycle arrest and apoptosis induction by ubenimex in glioma cell lines.
Glioma
Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner.
Glioma
c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells.
Glioma
Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells.
Glioma
CAAT/enhancer-binding protein delta and cAMP-response element-binding protein mediate inducible expression of the nerve growth factor gene in the central nervous system.
Glioma
CacyBP/SIP protein is important for the proliferation of human glioma cells.
Glioma
CAMTA1, a novel antitumor gene, regulates proliferation and the cell cycle in glioma by inhibiting AKT phosphorylation.
Glioma
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Glioma
Casein kinase 1 (CK1) promotes the proliferation and metastasis of glioma cells via the phosphatidylinositol 3 kinase-matrix metalloproteinase 2 (AKT-MMP2) pathway.
Glioma
Casein kinase 2 inhibition modulates the DNA damage response but fails to radiosensitize malignant glioma cells.
Glioma
Casein Kinase 2 Interacting Protein-1 Suppresses Glioma Cell Proliferation via Regulating the AKT/GSK3?/?-Catenin Pathway.
Glioma
Casein kinase ii (protein kinase ck2) regulates serotonin 5-ht(3) receptor channel function in ng108-15 cells.
Glioma
CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2.
Glioma
CD163, a novel therapeutic target, regulates the proliferation and stemness of glioma cells via casein kinase 2.
Glioma
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Glioma
Characterization of Glioma Stem Cells Through Multiple Stem Cell Markers and Their Specific Sensitization to Double-Strand Break-Inducing Agents by Pharmacological Inhibition of Ataxia Telangiectasia Mutated Protein.
Glioma
Combination of lithium chloride and pEGFP-N1-BmK CT effectively decreases proliferation and migration of C6 glioma cells.
Glioma
Connexin 30 mediated rewiring of glucose metabolism in rat C6 xenograft and grades of glioma.
Glioma
Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas.
Glioma
Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential.
Glioma
Constitutive activation of Raf-1 induces glioma formation in mice.
Glioma
Creation of an apoptin-derived peptide that interacts with SH3 domains and inhibits glioma cell migration and invasion.
Glioma
Cyclic AMP and AKAP-mediated targeting of protein kinase A regulates lactate dehydrogenase subunit A mRNA stability.
Glioma
Cyclic AMP-mediated induction of the glial fibrillary acidic protein is independent of protein kinase A activation in rat C6 glioma.
Glioma
Decreased MiR-17 in glioma cells increased cell viability and migration by increasing the expression of Cyclin D1, p-Akt and Akt.
Glioma
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.
Glioma
Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-kappaB signaling.
Glioma
Demethoxycurcumin analogue DMC-BH exhibits potent anticancer effects on orthotopic glioblastomas.
Glioma
Differential expression of centrosomal proteins at different stages of human glioma.
Glioma
Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics.
Glioma
Differentiation antagonizing non-protein coding RNA modulates the proliferation, migration, and angiogenesis of glioma cells by targeting the miR-216a/LGR5 axis and the PI3K/AKT signaling pathway.
Glioma
Disrupted in schizophrenia 1 (DISC1) inhibits glioblastoma development by regulating mitochondria dynamics.
Glioma
DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein.
Glioma
DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation.
Glioma
Down-regulation of 14-3-3? exerts anti-cancer effects through inducing ER stress in human glioma U87 cells: Involvement of CHOP-Wnt pathway.
Glioma
Downregulation of 14-3-3? inhibits proliferation and migration in osteosarcoma cells.
Glioma
Drak/STK17A drives neoplastic glial proliferation through modulation of MRLC signaling.
Glioma
Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival.
Glioma
Effect of inhibition of the ROCK isoform on RT2 malignant glioma cells.
Glioma
Effects of insulin on protein phosphorylation and protein kinase C activity in human malignant gliomas.
Glioma
Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis.
Glioma
EGFR inhibitor enhances cisplatin sensitivity of human glioma cells.
Glioma
EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma.
Glioma
EGFRvIII promotes glioma angiogenesis and growth through the NF-?B, interleukin-8 pathway.
Glioma
EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.
Glioma
Endoplasmic Reticulum Stress Contributes to Gefitinib-Induced Apoptosis in Glioma.
Glioma
Endosomal mTORC2 Is Required for Phosphoinositide-Dependent AKT Activation in Platelet-Derived Growth Factor-Stimulated Glioma Cells.
Glioma
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib.
Glioma
Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth.
Glioma
Eps8 promotes cellular growth of human malignant gliomas.
Glioma
Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo.
Glioma
Expression of pERK and pAKT in pediatric high grade astrocytomas: Correlation with YKL40 and prognostic significance.
Glioma
Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation.
Glioma
Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells.
Glioma
FKBP10 promotes proliferation of glioma cells via activating AKT-CREB-PCNA axis.
Glioma
Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma.
Glioma
Ganglioside GM1 activates the mitogen-activated protein kinase Erk2 and p70 S6 kinase in U-1242 MG human glioma cells.
Glioma
GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 and AKT Signaling Pathways.
Glioma
Ghrelin induces cell migration through GHS-R, CaMKII, AMPK and NF-kappaB signaling pathway in glioma cells.
Glioma
Ginkgo biloba extract regulates differentially the cell death induced by hydrogen peroxide and simvastatin.
Glioma
Glioma: Tryptophan Catabolite and Melatoninergic Pathways Link microRNA, 14-3- 3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes.
Glioma
GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population.
Glioma
Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner.
Glioma
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation.
Glioma
Glycogen synthase kinase-3? (GSK-3?) and its dysregulation in glioblastoma multiforme.
Glioma
Glycogen synthase kinases-3beta controls differentiation of malignant glioma cells.
Glioma
High expression of PFTK1 in cancer cells predicts poor prognosis in colorectal cancer.
Glioma
High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.
Glioma
Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c-Jun signaling pathway.
Glioma
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
Glioma
Identification of WHO II/III gliomas by 16 prognostic-related gene signatures using machine learning methods.
Glioma
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Glioma
Improved ataxia telangiectasia mutated kinase inhibitor KU60019 provides a promising treatment strategy for non-invasive breast cancer.
Glioma
Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells.
Glioma
Increased expression of platelet-derived growth factor associated protein-1 is associated with PDGF-B mediated glioma progression.
Glioma
Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments.
Glioma
Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells.
Glioma
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
Glioma
Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1.
Glioma
Inhibition of MAPK/ERK, PKC and CaMKII signaling blocks cytolysin-induced human glioma cell death.
Glioma
Inhibition of Metabolic Shift can Decrease Therapy Resistance in Human High-Grade Glioma Cells.
Glioma
Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and ?-catenin signaling pathways.
Glioma
Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy.
Glioma
Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
Glioma
Isoform-specific expression and characterization of 14-3-3 proteins in human glioma tissues discovered by stable isotope labeling with amino acids in cell culture-based proteomic analysis.
Glioma
Isoform-specific expression of 14-3-3 proteins in human astrocytoma.
Glioma
ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
Glioma
Knockdown lncRNA DLEU1 Inhibits Gliomas Progression and Promotes Temozolomide Chemosensitivity by Regulating Autophagy.
Glioma
Knockdown of Rho-associated protein kinase 1 suppresses proliferation and invasion of glioma cells.
Glioma
Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells.
Glioma
Lactate dehydrogenase A subunit messenger RNA stability is synergistically regulated via the protein kinase A and C signal transduction pathways.
Glioma
LATS2 Inhibits Malignant Behaviors of Glioma Cells via Inactivating YAP.
Glioma
Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signalling.
Glioma
Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3.
Glioma
Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas.
Glioma
Long noncoding RNA LINC00346 promotes glioma cell migration, invasion and proliferation by up-regulating ROCK1.
Glioma
Mechanisms of resistance of human glioma cells to Apo2 ligand/TNF-related apoptosis-inducing ligand.
Glioma
microRNA-124 inhibits migration and invasion by down-regulating ROCK1 in glioma.
Glioma
microRNA-153 Targets mTORC2 Component Rictor to Inhibit Glioma Cells.
Glioma
MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway.
Glioma
MicroRNA-361-5p slows down gliomas development through regulating UBR5 to elevate ATMIN protein expression.
Glioma
MicroRNA-379 inhibits cell proliferation and invasion in glioma via targeting metadherin and regulating PTEN/AKT pathway.
Glioma
MicroRNA-505-3p inhibits development of glioma by targeting HMGB1 and regulating AKT expression.
Glioma
MicroRNA-584-3p reduces the vasculogenic mimicry of human glioma cells by regulating hypoxia-induced ROCK1 dependent stress fiber formation.
Glioma
MicroRNA-584-3p, a novel tumor suppressor and prognostic marker, reduces the migration and invasion of human glioma cells by targeting hypoxia-induced ROCK1.
Glioma
MicroRNA-7 directly targets insulin-like growth factor 1 receptor to inhibit cellular growth and glucose metabolism in gliomas.
Glioma
Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis.
Glioma
miR-128-3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1.
Glioma
miR-128-3p inhibits glioma cell proliferation and differentiation by targeting NPTX1 through IRS-1/PI3K/AKT signaling pathway.
Glioma
MiR-130b can suppress proliferation of glioma cells through targeting PTEN to regulate AKT pathway.
Glioma
miR-221/222 promote malignant progression of glioma through activation of the Akt pathway.
Glioma
MiR-592 suppresses the development of glioma by regulating Rho-associated protein kinase.
Glioma
miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathways.
Glioma
MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.
Glioma
Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma.
Glioma
MutL homolog 1 contributes to temozolomide-induced autophagy via ataxia-telangiectasia mutated in glioma.
Glioma
Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).
Glioma
Norepinephrine increases I kappa B alpha expression in astrocytes.
Glioma
Opposing Signaling of ROCK1 and ROCK2 Determines the Switching of Substrate Specificity and the Mode of Migration of Glioblastoma Cells.
Glioma
Over-expression of Rap2a inhibits glioma migration and invasion by down-regulating p-AKT.
Glioma
Overexpression of FBXO17 Promotes the Proliferation, Migration and Invasion of Glioma Cells Through the Akt/GSK-3?/Snail Pathway.
Glioma
Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways.
Glioma
Overexpression of Protease Serine 8 Inhibits Glioma Cell Proliferation, Migration, and Invasion via Suppressing the Akt/mTOR Signaling Pathway.
Glioma
P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B.
Glioma
PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.
Glioma
pERK, pAkt and pBad: A Possible Role in Cell Proliferation and Sustained Cellular Survival During Tumorigenesis and Tumor Progression in ENU Induced Transplacental Glioma Rat Model.
Glioma
Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors.
Glioma
Plausible role of naringenin against cerebrally implanted C6 glioma cells in rats.
Glioma
Polarized regulation of glycogen synthase kinase-3? is important for glioma cell invasion.
Glioma
Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.
Glioma
Prolongation of life in rats with malignant glioma by intranasal siRNA/drug co-delivery to the brain with cell-penetrating peptide-modified micelles.
Glioma
Propofol Inhibits the Migration and Invasion of Glioma Cells by Blocking the PI3K/AKT Pathway Through miR-206/ROCK1 Axis.
Glioma
Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK.
Glioma
Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin.
Glioma
Protein kinase D2 promotes the proliferation of glioma cells by regulating Golgi phosphoprotein 3.
Glioma
Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.
Glioma
Radiomics of Pediatric Low-Grade Gliomas: Toward a Pretherapeutic Differentiation of BRAF-Mutated and BRAF-Fused Tumors.
Glioma
Raf kinase inhibitor protein (RKIP) inhibits the cell migration and invasion in human glioma cell lines in vitro.
Glioma
Reduced phosphorylation of Stat3 at Ser-727 mediated by Casein Kinase 2 - Protein Phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells.
Glioma
Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma.
Glioma
Regulation of connexin 43 and microRNA expression via ?2-adrenoceptor signaling in 1321N1 astrocytoma cells.
Glioma
Regulation of glycogen synthase kinase-3 beta (GSK-3?) by the Akt pathway in gliomas.
Glioma
RNA Interference-Mediated Aurora Kinase A Gene Silencing Inhibits Human Glioma Cells Proliferation and Tumor Growth in Mice.
Glioma
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Glioma
ROCK1, a novel target of miR-145, promotes glioma cell invasion.
Glioma
Rocks are expressed in brain tumors and are required for glioma-cell migration on myelinated axons.
Glioma
Role of cAMP-Dependent Protein Kinase A Activity in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood-Tumor Barrier.
Glioma
RSK4: a new prognostic factor in glioma.
Glioma
s-Myc acts as a transcriptional activator and its sequence-specific DNA binding is required for induction of programmed cell death in glioma cells.
Glioma
Second messenger-dependent protein kinases and protein synthesis regulate endogenous secretin receptor responsiveness.
Glioma
Selection of suitable reference genes for expression analysis in human glioma using RT-qPCR.
Glioma
Selective distribution of protein kinase A regulatory subunit RII{alpha} in rodent gliomas.
Glioma
Sensitization of cerebral tissue in nude mice with photodynamic therapy induces ADAM17/TACE and promotes glioma cell invasion.
Glioma
Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-?B-dependent Manner.
Glioma
Serum ROCK1 mRNA is of great diagnostic value for glioma patients.
Glioma
Sevoflurane Inhibits Glioma Cells Proliferation and Metastasis through miRNA-124-3p/ROCK1 Axis.
Glioma
Sevoflurane suppresses glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis.
Glioma
Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.
Glioma
Silencing Drp1 inhibits glioma cells proliferation and invasion by RHOA/ ROCK1 pathway.
Glioma
Silencing of ataxia-telangiectasia mutated by siRNA enhances the in vitro and in vivo radiosensitivity of glioma.
Glioma
Silencing of ATM expression by siRNA technique contributes to glioma stem cell radiosensitivity in vitro and in vivo.
Glioma
Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.
Glioma
Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme.
Glioma
Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase.
Glioma
Ste20-like kinase is upregulated in glioma and induces glioma invasion.
Glioma
Structural determinants for post-transcriptional stabilization of lactate dehydrogenase A mRNA by the protein kinase C signal pathway.
Glioma
T11TS immunotherapy repairs PI3K-AKT signaling in T-cells: Clues toward enhanced T-cell survival in rat glioma model.
Glioma
T11TS inhibits Angiopoietin-1/Tie-2 signaling, EGFR activation and Raf/MEK/ERK pathway in brain endothelial cells restraining angiogenesis in glioma model.
Glioma
Targeted activation of PKA and Epac promotes glioblastoma regression in vitro.
Glioma
Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice.
Glioma
Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling.
Glioma
Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Glioma
Targeting the mitogen?activated protein kinase kinase and protein kinase A pathways overcomes acquired resistance to Selumetinib in low?grade glioma cells.
Glioma
Tetraarsenic oxide-induced inhibition of malignant glioma cell invasion in vitro via a decrease in matrix metalloproteinase secretion and protein kinase B phosphorylation.
Glioma
The binding of lncRNA RP11-732M18.3 with 14-3-3 ?/? accelerates p21 degradation and promotes glioma growth.
Glioma
The effect of miR-21 on SWOZ2 glioma cells and its biological mechanism.
Glioma
The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells.
Glioma
The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling.
Glioma
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
Glioma
The NRG3/ERBB4 signaling cascade as a novel therapeutic target for canine glioma.
Glioma
The positive correlation between DJ-1 and ?-catenin expression shows prognostic value for patients with glioma.
Glioma
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas.
Glioma
The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas.
Glioma
The role of glycogen synthase kinase-3beta in glioma cell apoptosis induced by remifentanil.
Glioma
The SIAH1-HIPK2-p53ser46 damage response pathway is involved in temozolomide-induced glioblastoma cell death.
Glioma
TP53 modulates radiotherapy fraction size sensitivity in normal and malignant cells.
Glioma
Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells.
Glioma
Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathways.
Glioma
Up-regulation of HCRP1 inhibits proliferation and invasion in glioma cells via suppressing the ERK and AKT signaling pathways.
Glioma
Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase A signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes.
Glioma
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.
Glioma
Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells.
Glioma
Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells.
Glioma
[Cellular reactions after stimulation of receptors: research model for evaluation of effects and action mechanisms of drugs for discovery of innovative drugs]
Glioma
[RNA interference targeting DNA-PKcs inhibits glioma cells malignancies and enhances temozolomide sensitivity].
Glomerulonephritis
A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase.
Glomerulonephritis
A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1.
Glomerulonephritis
Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.
Glomerulonephritis
Involvement of prostaglandin E2 in clearance of aggregated protein via protein kinase A in glomeruli.
Glomerulonephritis
[Induction of monocyte chemoattractant protein-1 expression in human mesangial cells by angiotensin II: role of c-Jun N-terminal kinase-c-Jun/activator protein-1 signal pathway]
Glomerulonephritis, IGA
Activation of the interleukin-4/signal transducer and activator of transcription 6 signaling pathway and homeodomain-interacting protein kinase 2 production by tonsillar mononuclear cells in IgA nephropathy.
Glomerulonephritis, IGA
Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy.
Glomerulonephritis, IGA
Role of HIPK2 in kidney fibrosis.
Glomerulonephritis, IGA
The family of 14-3-3 proteins and specifically 14-3-3? are up-regulated during the development of renal pathologies.
Glomerulonephritis, Membranous
Complement activates the c-Jun N-terminal kinase/stress-activated protein kinase in glomerular epithelial cells.
Glomerulonephritis, Membranous
The family of 14-3-3 proteins and specifically 14-3-3? are up-regulated during the development of renal pathologies.
Glomerulonephritis, Membranous
Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.
Glomerulosclerosis, Focal Segmental
Role of HIPK2 in kidney fibrosis.
Glucagonoma
Expression, intracellular localization, and gene transcription regulation of the secretory protein 7B2 in endocrine pancreatic cell lines and human insulinomas.
Glucose Intolerance
Acute inhibition of central c-Jun N-terminal kinase restores hypothalamic insulin signalling and alleviates glucose intolerance in diabetic mice.
Glucose Intolerance
Ameliorative effect of low-dose spironolactone on obesity and insulin resistance is through replenishment of estrogen in ovariectomized rats.
Glucose Intolerance
Blockade of mineralocorticoid receptor ameliorates oral contraceptive-induced insulin resistance by suppressing elevated uric acid and glycogen synthase kinase-3 instead of circulating mineralocorticoid.
Glucose Intolerance
Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.
Glucose Intolerance
Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.
Glucose Intolerance
Differentially regulated protein kinase A (PKA) activity in adipose tissue and liver is associated with resistance to diet-induced obesity and glucose intolerance in mice that lack PKA regulatory subunit type II?.
Glucose Intolerance
Double-Stranded RNA-Activated Protein Kinase Is a Key Modulator of Insulin Sensitivity in Physiological Conditions and in Obesity in Mice.
Glucose Intolerance
Ginsenoside Mc1 improves liver steatosis and insulin resistance by attenuating ER stress.
Glucose Intolerance
Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise.
Glucose Intolerance
Inhibition of pancreatic beta-cell CaMKII reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.
Glucose Intolerance
Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.
Glucose Intolerance
LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance via Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes.
Glucose Intolerance
Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein.
Glucose Intolerance
Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle.
Glucose Intolerance
Novel roles for JNK1 in metabolism.
Glucose Intolerance
Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus.
Glucose Intolerance
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.
Glucose Intolerance
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity.
Glucose Intolerance
STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3 beta.
Glucose Intolerance
The expression of CCN2, IQSEC, RSPO1, DNAJC15, RIPK2, IL13RA2, IRS1, and IRS2 genes in blood of obese boys with insulin resistance.
Glucose Intolerance
The mammalian target of rapamycin signaling network and gene regulation.
glutamate-5-semialdehyde dehydrogenase deficiency
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Glycosuria
Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in streptozotocin-induced diabetic rats.
Goiter
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Gonadal Dysgenesis
Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene.
Gout
Cell lineage-specific methylome and genome alterations in gout.
Graft vs Host Disease
Aurora A controls CD8+ T cell cytotoxic activity and antiviral response.
Graft vs Host Disease
Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and its Pharmacokinetic Application.
Graft vs Host Disease
PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.
Granuloma
Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon ?-activated murine macrophages and animal models of inflammation.
Granulosa Cell Tumor
14-3-3 sigma is a useful immunohistochemical marker for diagnosing ovarian granulosa cell tumors and steroid cell tumors.
Graves Disease
[Effect of Jiakangning Capsule on Thyroid Function and Akt/mTOR Signal Pathway of Graves' Disease Mice: an Experimental Study].
Guillain-Barre Syndrome
Detection of CSF 14-3-3 protein in Guillain-Barré syndrome.
Gynecomastia
Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for prepubertal gynecomastia in boys with Peutz Jeghers Syndrome.
Hallucinations
An unusual case of sporadic Creutzfeldt-Jakob disease (CJD).
Hallucinations
LRRK2 G2019S mutation in Parkinson's disease: A neuropsychological and neuropsychiatric study in a large Algerian cohort.
Hamartoma
A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.
Hamartoma
Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis.
Hamartoma
Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability.
Hamartoma
Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.
Hamartoma
Intestinal renin-angiotensin system is stimulated after deletion of Lkb1.
Hamartoma
LKB1 modulates lung cancer differentiation and metastasis.
Hamartoma
Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.
Hamartoma
Peutz-Jeghers syndrome.
Hamartoma
Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.
Hamartoma
Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient.
Hamartoma Syndrome, Multiple
Hereditary breast cancer: the era of new susceptibility genes.
Hamartoma Syndrome, Multiple
Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA.
Hashimoto Disease
PD-L1, PDK-1 and p-Akt are correlated in patients with papillary thyroid carcinoma.
Head and Neck Neoplasms
14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells.
Head and Neck Neoplasms
Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer.
Head and Neck Neoplasms
Ataxia-telangiectasia mutated interactor regulates head and neck cancer metastasis via KRas expression.
Head and Neck Neoplasms
Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer.
Head and Neck Neoplasms
DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery.
Head and Neck Neoplasms
Expression and significance of CD44 and p-AKT in pancreatic head cancer.
Head and Neck Neoplasms
IL-6 stabilizes Twist and enhances tumor cell motility in head and neck cancer cells through activation of casein kinase 2.
Head and Neck Neoplasms
Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in saudi arabia.
Head and Neck Neoplasms
Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer.
Head and Neck Neoplasms
Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer.
Head and Neck Neoplasms
The immunohistochemical expression of DNA-PKCS and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity.
Head and Neck Neoplasms
The Mechanistic Role of the Calcium-Activated Chloride Channel ANO1 in Tumor Growth and Signaling.
Head and Neck Neoplasms
Therapeutic targeting of protein kinase CK2 gene expression in feline oral squamous cell carcinoma - a naturally occurring large animal model of head and neck cancer.
Hearing Loss
A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss.
Hearing Loss
A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.
Hearing Loss
Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity.
Hearing Loss
D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma.
Hearing Loss
Gene-BIT Life Sciences' third annual world congress. Anti-neurodegenerative and anti-inflammation biotherapeutics.
Hearing Loss, Noise-Induced
A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.
Hearing Loss, Noise-Induced
Activated protein C rescues the cochlea from noise-induced hearing loss.
Hearing Loss, Noise-Induced
The expression of mitogen-activated protein kinases and brain-derived neurotrophic factor in inferior colliculi after acoustic trauma.
Hearing Loss, Sensorineural
Efficacy and safety of AM-111 in the treatment of acute sensorineural hearing loss: a double-blind, randomized, placebo-controlled phase II study.
Hearing Loss, Sensorineural
Efficacy and Safety of AM-111 in the Treatment of Acute Unilateral Sudden Deafness-A Double-blind, Randomized, Placebo-controlled Phase 3 Study.
Heart Arrest
Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia.
Heart Arrest
Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma.
Heart Arrest
Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest.
Heart Arrest
Calcium/Calmodulin-Dependent Kinase (CaMKII) Inhibition Protects Against Purkinje Cell Damage Following CA/CPR in Mice.
Heart Arrest
CaMKII versus DAPK1 Binding to GluN2B in Ischemic Neuronal Cell Death after Resuscitation from Cardiac Arrest.
Heart Arrest
Effects of NaHS and hydroxylamine on the expressions of brain-derived neurotrophic factor and its receptors in rats after cardiac arrest and cardiopulmonary resuscitation.
Heart Arrest
Isoflurane pretreatment ameliorates postischemic neurologic dysfunction and preserves hippocampal Ca2+/calmodulin-dependent protein kinase in a canine cardiac arrest model.
Heart Arrest
[Tea polyphenols down-regulate JNK phosphorylation to inhibit neuron apoptosis in rats with cardiac arrest].
Heart Defects, Congenital
Akap12beta supports asymmetric heart development via modulating the Kupffer's vesicle formation in zebrafish.
Heart Defects, Congenital
Combined effects of AKT serine/threonine kinase 1 polymorphisms and environment on congenital heart disease risk: A case-control study.
Heart Defects, Congenital
Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca
Heart Defects, Congenital
Isoforms of troponin in normal and diseased myocardium.
Heart Defects, Congenital
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Defects, Congenital
The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry.
Heart Diseases
A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.
Heart Diseases
A targeted library screen reveals a new inhibitor scaffold for protein kinase D.
Heart Diseases
Assessment of PIM-2 performance among surgical patients with heart disease and correlation of results with RACHS-1.
Heart Diseases
Astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing Ca²?-mediated calcineurin/NFATc3 and CaMKII signaling cascades.
Heart Diseases
Calm down when the heart is stressed: Inhibiting calmodulin-dependent protein kinase II for antiarrhythmias.
Heart Diseases
Calmodulin kinase II inhibition protects against structural heart disease.
Heart Diseases
Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias.
Heart Diseases
CaMKII Activity in the Inflammatory Response of Cardiac Diseases.
Heart Diseases
CaMKII and its role in cardiac arrhythmia.
Heart Diseases
CaMKII and stress mix it up in mitochondria.
Heart Diseases
CaMKII confirms its promise in ischaemic heart disease.
Heart Diseases
CaMKII inhibitors: from research tools to therapeutic agents.
Heart Diseases
CaMKII oxidative activation and the pathogenesis of cardiac disease.
Heart Diseases
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Heart Diseases
CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction.
Heart Diseases
CaMKII: The molecular villain that aggravates cardiovascular disease.
Heart Diseases
Chasing cardiac physiology and pathology down the CaMKII cascade.
Heart Diseases
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy.
Heart Diseases
Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.
Heart Diseases
Glycogen synthase kinase-3? inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction.
Heart Diseases
Heart failure-specific changes in protein kinase signalling.
Heart Diseases
Inflammation in non-ischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling.
Heart Diseases
Modeling CaMKII in cardiac physiology: from molecule to tissue.
Heart Diseases
Multiple downstream proarrhythmic targets for calmodulin kinase II: moving beyond an ion channel-centric focus.
Heart Diseases
NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII.
Heart Diseases
Nuclear Ca2+/calmodulin-dependent protein kinase II in the murine heart.
Heart Diseases
Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.
Heart Diseases
Research progress on the role of CaMKII in heart disease.
Heart Diseases
Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.
Heart Diseases
Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: insights from mathematical modeling.
Heart Diseases
Role of CaMKII for signaling and regulation in the heart.
Heart Diseases
Role of CaMKII in cardiac arrhythmias.
Heart Diseases
Roles of Glycogen Synthase Kinase-3 (GSK-3) in Cardiac Development and Heart Disease.
Heart Diseases
Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca(2+) release events in a rodent model of early stage diabetes: The arrhythmogenic substrate.
Heart Diseases
The cardiac CaMKII-Nav1.5 relationship: From physiology to pathology.
Heart Diseases
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Heart Diseases
The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias.
Heart Diseases
The role of CaMKII regulation of phospholamban activity in heart disease.
Heart Diseases
The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart.
Heart Diseases
Troponin I-interacting protein kinase: a novel cardiac-specific kinase, emerging as a molecular target for the treatment of cardiac disease.
Heart Failure
2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.
Heart Failure
2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation.
Heart Failure
?IIPKC and ?PKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure.
Heart Failure
A CaMKII/PDE4D negative feedback regulates cAMP signaling.
Heart Failure
A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation.
Heart Failure
A molecular formula for heart failure and sudden cardiac death. Focus on "Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice".
Heart Failure
A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.
Heart Failure
A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.
Heart Failure
A-kinase anchoring proteins that regulate cardiac remodeling.
Heart Failure
Abnormal ryanodine receptor function in heart failure.
Heart Failure
Activation of CaMKII?A promotes Ca2+ leak from the sarcoplasmic reticulum in cardiomyocytes of chronic heart failure rats.
Heart Failure
All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation.
Heart Failure
Alterations in protein kinase A and protein kinase C levels in heart failure due to genetic cardiomyopathy.
Heart Failure
Altered function and regulation of cardiac ryanodine receptors in cardiac disease.
Heart Failure
Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II.
Heart Failure
AMPK blunts chronic heart failure by inhibiting autophagy.
Heart Failure
Astragalus Granule Prevents Ca(2+) Current Remodeling in Heart Failure by the Downregulation of CaMKII.
Heart Failure
Ataxia telangiectasia mutated kinase is an autophagic balancer at the onset of heart failure.
Heart Failure
beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure.
Heart Failure
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
Heart Failure
c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.
Heart Failure
Ca(2+)-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling.
Heart Failure
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart.
Heart Failure
Ca2+/calmodulin-dependent protein kinase II is essential in hyperacute pressure overload.
Heart Failure
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.
Heart Failure
Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure.
Heart Failure
Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.
Heart Failure
Calcium/Calmodulin-dependent Kinase II Regulation of Cardiac Ion Channels.
Heart Failure
Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.
Heart Failure
Calcium/calmodulin-dependent protein kinase II regulation of I
Heart Failure
Calm down when the heart is stressed: Inhibiting calmodulin-dependent protein kinase II for antiarrhythmias.
Heart Failure
CaMKII and GLUT1 in heart failure and the role of gliflozins.
Heart Failure
CaMKII determines mitochondrial stress responses in heart.
Heart Failure
CaMKII exacerbates heart failure progression by activating class I HDACs.
Heart Failure
CaMKII in myocardial hypertrophy and heart failure.
Heart Failure
CaMKII in sinoatrial node physiology and dysfunction.
Heart Failure
CaMKII in the cardiovascular system: sensing redox states.
Heart Failure
CaMKII inhibition in heart failure makes jump to human.
Heart Failure
CaMKII Inhibition in Heart Failure, Beneficial, Harmful or Both.
Heart Failure
CaMKII Inhibition is a Novel Therapeutic Strategy to Prevent Diabetic Cardiomyopathy.
Heart Failure
CaMKII inhibitors: from research tools to therapeutic agents.
Heart Failure
CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis.
Heart Failure
CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure.
Heart Failure
CaMKII regulation of voltage-gated Na channels and cell excitability.
Heart Failure
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Heart Failure
CaMKII-?9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair.
Heart Failure
CaMKII-dependent regulation of cardiac Na(+) homeostasis.
Heart Failure
CaMKII? post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes.
Heart Failure
CaMKIIdelta orchestrates G protein coupled receptor and electric field stimulation-induced cardiomyocyte hypertrophy.
Heart Failure
CaMKIIdelta overexpression in hypertrophy and heart failure: cellular consequences for excitation-contraction coupling.
Heart Failure
Cardiac CaM Kinase II genes ? and ? contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.
Heart Failure
Cardiac Hypertrophy and Heart Failure Development Through Gq and CaM Kinase II Signaling.
Heart Failure
Cardiac Protection of Valsartan on Juvenile Rats with Heart Failure by Inhibiting Activity of CaMKII via Attenuating Phosphorylation.
Heart Failure
Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right.
Heart Failure
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.
Heart Failure
Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase Signaling.
Heart Failure
Carvedilol restore cardiac calcium release channel structure and function in heart failure.
Heart Failure
Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.
Heart Failure
Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition Rescues Advanced Heart Failure.
Heart Failure
Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure.
Heart Failure
Circ-Zfp644 acts as a pro-hypertrophic mediator in an Ang-II induced in vitro myocardial hypertrophy model.
Heart Failure
Crosstalk between GSK-3?-actuated molecular cascades and myocardial physiology.
Heart Failure
Cyclic AMP-dependent protein kinase a regulates the alternative splicing of CaMKII?.
Heart Failure
Decoding the cardiac actions of protein kinase D isoforms.
Heart Failure
Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart.
Heart Failure
Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice.
Heart Failure
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation.
Heart Failure
Downregulation of survival signaling pathways and increased apoptosis in the transition of pressure overload-induced cardiac Hypertrophy towards to heart failure.
Heart Failure
Dysfunctional ryanodine receptors in the heart: New insights into complex cardiovascular diseases.
Heart Failure
Effect of metoprolol on sarcoplasmic reticulum Ca2+ leak in a rabbit model of heart failure.
Heart Failure
Effects on recovery during acidosis in cardiac myocytes overexpressing CaMKII.
Heart Failure
Emerging Role for RBM20 and Its Splicing Substrates in Cardiac Function and Heart Failure.
Heart Failure
Enhanced CaMKII-Dependent Late INa Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.
Heart Failure
Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets.
Heart Failure
Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure.
Heart Failure
Exendin-4 therapy still offered an additional benefit on reducing transverse aortic constriction-induced cardiac hypertrophy-caused myocardial damage in DPP-4 deficient rats.
Heart Failure
Experimental antiarrhythmic targets: CaMKII inhibition - Ready for clinical evaluation?
Heart Failure
Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.
Heart Failure
Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca2+-dependent cardiomyopathy by exacerbating diastolic Ca2+ release.
Heart Failure
Glioblastoma following treatment with fingolimod for relapsing-remitting multiple sclerosis.
Heart Failure
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
Heart Failure
GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1.
Heart Failure
GSK-3beta, a therapeutic target for cardiomyocyte protection.
Heart Failure
Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction.
Heart Failure
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Heart Failure
Heart failure-specific changes in protein kinase signalling.
Heart Failure
Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP-PKA Interactions.
Heart Failure
Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state.
Heart Failure
Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure.
Heart Failure
Inhibition of CaMKII Attenuates Progressing Disruption of Ca(2+) Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure.
Heart Failure
Inhibition of cardiac CaMKII to cure heart failure: step by step towards translation?
Heart Failure
Inhibition of glycogen synthase kinase 3beta during heart failure is protective.
Heart Failure
Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor.
Heart Failure
Integrated mechanisms of CaMKII-dependent ventricular remodeling.
Heart Failure
Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart.
Heart Failure
Kallikrein teams up with GSK-3beta in heart failure prevention.
Heart Failure
Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure.
Heart Failure
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.
Heart Failure
Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury.
Heart Failure
Maximum phosphorylation of the cardiac ryanodine receptor at serine-2809 by protein kinase a produces unique modifications to channel gating and conductance not observed at lower levels of phosphorylation.
Heart Failure
MicroRNA and receptor mediated signaling pathways as potential therapeutic targets in heart failure.
Heart Failure
Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal s6 kinase 2 inhibitors.
Heart Failure
Modulation of HERG K+ channels by chronic exposure to activators and inhibitors of PKA and PKC: actions independent of PKA and PKC phosphorylation.
Heart Failure
More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.
Heart Failure
NMR solution structure and topological orientation of monomeric phospholamban in dodecylphosphocholine micelles.
Heart Failure
Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use?
Heart Failure
Novel function of cardiac protein kinase D as a dynamic regulator of CA2+ sensitivity of contraction.
Heart Failure
p38 mitogen-activated protein kinase: a future target for heart failure therapy?
Heart Failure
Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice.
Heart Failure
Phospholamban phosphorylation by CaMKII under pathophysiological conditions.
Heart Failure
Phosphoproteomics Study Based on In Vivo Inhibition Reveals Sites of Calmodulin-Dependent Protein Kinase II Regulation in the Heart.
Heart Failure
Phosphorylation of phospholamban at threonine-17 reduces cardiac adrenergic contractile responsiveness in chronic pressure overload-induced hypertrophy.
Heart Failure
PINCH Proteins Regulate Cardiac Contractility by Modulating Integrin-Linked Kinase-Protein Kinase B Signaling.
Heart Failure
Plasma concentration of receptor-interacting protein kinase-3 as a potential biomarker for diagnosis and prognosis in heart failure.
Heart Failure
Polyphenols from Arctium lappa L ameliorate doxorubicin-induced heart failure and improve gut microbiota composition in mice.
Heart Failure
Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor?
Heart Failure
Protein Kinase A as a Promising Target for Heart Failure Drug Development.
Heart Failure
Protein kinase A phosphorylation at serine-2808 of the cardiac Ca2+-release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6).
Heart Failure
Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol.
Heart Failure
Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes.
Heart Failure
Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca(2+) leak in mouse heart.
Heart Failure
Protein Kinases as Drug Development Targets for Heart Disease Therapy.
Heart Failure
Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology.
Heart Failure
Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation.
Heart Failure
Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity.
Heart Failure
Regulation of the cardiac repolarizing HERG potassium channel by protein kinase A.
Heart Failure
Regulatory role of CARD3 in left ventricular remodelling and dysfunction after myocardial infarction.
Heart Failure
Remodeling of excitation-contraction coupling in the heart: inhibition of sarcoplasmic reticulum Ca(2+) leak as a novel therapeutic approach.
Heart Failure
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Heart Failure
Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats.
Heart Failure
Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.
Heart Failure
ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice.
Heart Failure
Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.
Heart Failure
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart.
Heart Failure
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure.
Heart Failure
Role of CaMKII for signaling and regulation in the heart.
Heart Failure
Role of CaMKII in cardiac arrhythmias.
Heart Failure
Role of CaVbeta subunits, and lack of functional reserve, in protein kinase a modulation of cardiac CaV1.2 channels.
Heart Failure
Role of GSK-3 in Cardiac Health: Focusing on Cardiac Remodeling and Heart Failure.
Heart Failure
Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias: Protein Kinase A-Mediated Hyperphosphorylation of the Ryanodine Receptor at Serine 2808 Does Not Alter Cardiac Contractility or Cause Heart Failure and Arrhythmias.
Heart Failure
Rosuvastatin-attenuated heart failure in aged spontaneously hypertensive rats via PKC?/?2 signal pathway.
Heart Failure
Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca(2+) release events in a rodent model of early stage diabetes: The arrhythmogenic substrate.
Heart Failure
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.
Heart Failure
Signalling pathways in cardiac failure.
Heart Failure
Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials.
Heart Failure
Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch.
Heart Failure
Stretch Current-Induced Abnormal Impulses in CaMKII? Knockout Mouse Ventricular Myocytes.
Heart Failure
Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.
Heart Failure
The ?A isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway.
Heart Failure
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
Heart Failure
The Cardiac Ryanodine Receptor Phosphorylation Hotspot Embraces PKA in a Phosphorylation-Dependent Manner.
Heart Failure
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.
Heart Failure
The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on ?-adrenoceptors.
Heart Failure
The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity.
Heart Failure
The potential role of Kv4.3 K(+) channel in heart hypertrophy.
Heart Failure
The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias.
Heart Failure
The role of calmodulin kinase II in myocardial physiology and disease.
Heart Failure
The scaffold protein muscle A-kinase anchoring protein ? orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure.
Heart Failure
The signaling interplay of GSK-3? in myocardial disorders.
Heart Failure
Theoretical investigation of the mechanism of heart failure using a canine ventricular cell model: especially the role of up-regulated CaMKII and SR Ca(2+) leak.
Heart Failure
Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction.
Heart Failure
While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKII?-KO mice.
Heart Failure
YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways.
Heart Failure
[Abnormal calcium re-uptake in myocardium sarcoplasmic reticulum in rabbits with heart failure and the influencing factors].
Heart Failure
[Effect of Fuxin Mixture on The 01-AR-cAMP-PKA Pathway of Rats with Heart Failure].
Heart Failure
[Effects of ErbB signal and protein kinase B on monkey cardiocyte apoptosis induced by rapid pacing]
Heart Failure
[Effects of valsartan on sarcoplasmic reticulum calcium adenodine triphosphatase, protein kinase A and protein phosphatase 1 alpha in a rabbit model of heart failure]
Heart Failure
[Ranolazine in the prevention of anthracycline-related cardiotoxicity].
Heart Neoplasms
Tumors and the heart: molecular genetic advances.
Heart Rupture
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Heart Septal Defects, Atrial
Surgical repair for atrial septal defect associated with myotonic dystrophy.
Heart Septal Defects, Atrial
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Septal Defects, Ventricular
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Hemangioendothelioma
Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.
Hemangioma
Propranolol inhibits the activity of PI3K, AKT, and HIF-1? in infantile hemangiomas.
Hemangioma
Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.
Hemangioma, Cavernous, Central Nervous System
CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading.
Hemangiopericytoma
Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.
Hemangiosarcoma
Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: A pattern distinct from other sarcomas with complex genomics.
Hemangiosarcoma
Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.
Hemangiosarcoma
ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.
Hematologic Diseases
Effect of the conditional knockout of bone marrow specific RIPK3 gene on bone marrow hematopoiesis in mice.
Hematologic Neoplasms
A novel class of selective CK2 inhibitors targeting its open hinge conformation.
Hematologic Neoplasms
Analysis of Aurora kinase A expression in CD34(+) blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia.
Hematologic Neoplasms
Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias.
Hematologic Neoplasms
Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.
Hematologic Neoplasms
Casein Kinase II (CK2) as a Therapeutic Target for Hematological Malignancies.
Hematologic Neoplasms
CIGB-300: A peptide-based drug that impairs the Protein Kinase CK2-mediated phosphorylation.
Hematologic Neoplasms
CX-4945, a selective inhibitor of casein kinase 2, synergizes with B cell receptor signaling inhibitors in inducing diffuse large B cell lymphoma cell death.
Hematologic Neoplasms
CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway.
Hematologic Neoplasms
Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases.
Hematologic Neoplasms
Expression of Akt (protein kinase B) and its isoforms in malignant lymphomas.
Hematologic Neoplasms
Hyaluronan oligosaccharides sensitize lymphoma resistant cell lines to vincristine by modulating P-glycoprotein activity and PI3K/Akt pathway.
Hematologic Neoplasms
Insights from Pim1 structure for anti-cancer drug design.
Hematologic Neoplasms
Kinase signaling pathways as targets for intervention in pancreatic cancer.
Hematologic Neoplasms
Molecular pathways: Beta-adrenergic signaling in cancer.
Hematologic Neoplasms
Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells.
Hematologic Neoplasms
mTOR Regulation of Metabolism in Hematologic Malignancies.
Hematologic Neoplasms
Pim-3 is a Critical Risk Factor in Development and Prognosis of Prostate Cancer.
Hematologic Neoplasms
Potent antitumor effect of combination therapy with sub-optimal doses of Akt inhibitors and pomalidomide plus dexamethasone in multiple myeloma.
Hematologic Neoplasms
Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-Analysis.
Hematologic Neoplasms
Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways.
Hematologic Neoplasms
Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070.
Hematologic Neoplasms
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Hematologic Neoplasms
The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies.
Hematologic Neoplasms
The role of exosomes and MYC in therapy resistance of acute myeloid leukemia: Challenges and opportunities.
Hematologic Neoplasms
Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation.
Hematologic Neoplasms
Tumorigenesis and neurodegeneration: two sides of the same coin?
Hemimegalencephaly
Molecular pathogenesis of focal cortical dysplasia and hemimegalencephaly.
Hemorrhagic Stroke
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Hepatic Encephalopathy
Transport of AMPA receptors during long-term potentiation is impaired in rats with hepatic encephalopathy.
Hepatitis
Assembly of hepatitis delta virus particles: package of multimeric hepatitis delta virus genomic RNA and role of phosphorylation.
Hepatitis
Casein kinase II and protein kinase C modulate hepatitis delta virus RNA replication but not empty viral particle assembly.
Hepatitis
Coronavirus interactions with the cellular autophagy machinery.
Hepatitis
Expression of the serine/threonine kinase hSGK1 in chronic viral hepatitis.
Hepatitis
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Hepatitis
Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication.
Hepatitis
Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase.
Hepatitis
Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.
Hepatitis
Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells.
Hepatitis
Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?
Hepatitis B
A ?Raf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures.
Hepatitis B
Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability.
Hepatitis B
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod.
Hepatitis B
Detection of the human hepatitis B virus X-protein in transgenic mice after radioactive labelling at a newly introduced phosphorylation site.
Hepatitis B
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Hepatitis B
Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome.
Hepatitis B
Hepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3beta kinase pathways.
Hepatitis B
Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress.
Hepatitis B
Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase.
Hepatitis B
lncRNA HAND2?AS1 mediates the downregulation of ROCK2 in hepatocellular carcinoma and inhibits cancer cell proliferation, migration and invasion.
Hepatitis B
MicroRNA-520a suppresses HBV replication in HepG2.2.15 cells by inactivating AKT.
Hepatitis B
Molecular mechanism of hepatitis B virus (HBV) on suppression of raf kinase inhibitor protein (RKIP) expression.
Hepatitis B
Phosphorylation of human La protein at Ser 366 by casein kinase II contributes to hepatitis B virus replication and expression in vitro.
Hepatitis B
Phosphorylation of the core protein of hepatitis B virus by a 46-kilodalton serine kinase.
Hepatitis B
Properties of hepatitis B e antigen synthesized by rat cells transfected with circular viral DNA.
Hepatitis B
Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma.
Hepatitis B
Raf-1 and protein kinase B regulate cell survival through the activation of NF-kappaB in hepatitis B virus X-expressing cells.
Hepatitis B
Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression.
Hepatitis B
The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinase.
Hepatitis B
Tumor DNA-dependent protein kinase catalytic subunit expression is associated with hepatitis B surface antigen status and tumor progression in patients with hepatocellular carcinoma.
Hepatitis B
[Expressions of Raf-1 kinase, phosphorylated mitogen extracellular kinase 1, and phosphorylated extracellular signal-regulated protein kinase 1/2 in hepatocellular carcinoma and their relationship with prognosis]
Hepatitis B
[The effect and clinical significance of methylation of 14-3-3 sigma gene in hepatitis B virus-related hepatocellular carcinoma]
Hepatitis B, Chronic
[Activation of the interferon system enzymes by recombinant alpha2-interferon in patients with chronic hepatitis B]
Hepatitis C
A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.
Hepatitis C
Casein kinase II inhibitor enhances production of infectious genotype 1a hepatitis C virus (H77S).
Hepatitis C
Contrasting Roles of Mitogen-Activated Protein Kinases in Cellular Entry and Replication of Hepatitis C Virus: MKNK1 Facilitates Cell Entry.
Hepatitis C
Critical role of Casein kinase 2 in hepatitis C NS5A-mediated inhibition of Kv2.1 K(+) channel function.
Hepatitis C
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod.
Hepatitis C
Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein.
Hepatitis C
Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.
Hepatitis C
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.
Hepatitis C
Hepatitis C virus core protein potentiates c-Jun N-terminal kinase activation through a signaling complex involving TRADD and TRAF2.
Hepatitis C
Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis.
Hepatitis C
Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasome.
Hepatitis C
Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors.
Hepatitis C
Hepatitis C virus NS5A protein is phosphorylated by casein kinase II.
Hepatitis C
Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription.
Hepatitis C
Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes.
Hepatitis C
Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321.
Hepatitis C
Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-? in infectious virus production.
Hepatitis C
p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells.
Hepatitis C
Phosphorylated AKT expression in tumor-adjacent normal tissue is associated with poor prognosis in patients with hepatocellular carcinoma.
Hepatitis C
Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C.
Hepatitis C
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity.
Hepatitis C
Protein kinase C recognizes the protein kinase A-binding motif of nonstructural protein 3 of hepatitis C virus.
Hepatitis C
Protein Kinase D Negatively Regulates Hepatitis C Virus Secretion through Phosphorylation of Oxysterol-binding Protein and Ceramide Transfer Protein.
Hepatitis C
Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication.
Hepatitis C
Serine 235 Is the Primary NS5A Hyperphosphorylation Site Responsible for Hepatitis C Virus Replication.
Hepatitis C
Structural and molecular basis of interaction of HCV non-structural protein 5A with human casein kinase 1? and PKR.
Hepatitis C
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Hepatitis C
The flaviviral methyltransferase is a substrate of Casein Kinase 1.
Hepatitis C, Chronic
Hepatic Expression of Phosphorylated Kinase Akt and Glycogen Synthase Kinase-3 Isoforms in Patients with Chronic Hepatitis C.
Hepatitis C, Chronic
Lymphomagenesis-related gene expression in B cells from sustained virological responders with occult hepatitis C virus infection.
Hepatitis, Chronic
Clinical significance of serum 14-3-3 beta in patients with hepatocellular carcinoma.
Hepatitis, Chronic
Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4.
Hepatitis, Chronic
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma.
Hepatoblastoma
20(S)-Protopanaxadiol induces apoptosis in human hepatoblastoma HepG2 cells by downregulating the protein kinase B signaling pathway.
Hepatoblastoma
Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival.
Hepatoblastoma
Lycorine Induces Mitochondria-Dependent Apoptosis in Hepatoblastoma HepG2 Cells Through ROCK1 Activation.
Hepatoblastoma
Phosphorylation of c-Jun N-terminal kinase in human hepatoblastoma cells is transiently increased by cold exposure and further enhanced by subsequent warm incubation of the cells.
Hepatoblastoma
Pim-2 Activates API-5 to Inhibit the Apoptosis of Hepatocellular Carcinoma Cells Through NF-kappaB Pathway.
Hepatoblastoma
Rapamycin blocks hepatoblastoma growth in vitro and in vivo implicating new treatment options in high-risk patients.
Hepatoblastoma
Targeting Aurora A kinase with Alisertib (ALS) Induces Autophagy and Cell Cycle Arrest and Increases Chemosensitivity in Hepatoblastoma HepG2 Cells.
Hepatolenticular Degeneration
Creutzfeldt-Jakob disease masked by head trauma and features of Wilson's disease.
Hereditary Breast and Ovarian Cancer Syndrome
Genetic testing by cancer site: stomach.
Herpes Simplex
A novel gene expressed in human keratinocytes with long-term in vitro growth potential is required for cell growth.
Herpes Simplex
A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells.
Herpes Simplex
A truncated protein kinase domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) expressed in Escherichia coli.
Herpes Simplex
An HSV-2-based oncolytic virus deleted in the PK domain of the ICP10 gene is a potent inducer of apoptotic death in tumor cells.
Herpes Simplex
Casein kinase II specifically nucleotidylylates in vitro the amino acid sequence of the protein encoded by the alpha 22 gene of herpes simplex virus 1.
Herpes Simplex
Cellular Protein Kinase D Modulators Play a Role during Multiple Steps of Herpes Simplex Virus Type 1 Egress.
Herpes Simplex
Coronavirus interactions with the cellular autophagy machinery.
Herpes Simplex
Effects of lamin A/C, lamin B1, and viral US3 kinase activity on viral infectivity, virion egress, and the targeting of herpes simplex virus U(L)34-encoded protein to the inner nuclear membrane.
Herpes Simplex
Effects of Phosphorylation of Herpes Simplex Virus 1 Envelope Glycoprotein B by Us3 Kinase In Vivo and In Vitro.
Herpes Simplex
Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation.
Herpes Simplex
Expression of the cyclic AMP-dependent protein kinase (PKA) catalytic subunit from a herpes simplex virus vector extends the survival of rat sympathetic neurons in the absence of NGF.
Herpes Simplex
Herpes Simplex Virus 1 Protein Kinase Us3 and Major Tegument Protein UL47 Reciprocally Regulate Their Subcellular Localization in Infected Cells.
Herpes Simplex
Herpes simplex virus 1 protein kinase Us3 phosphorylates viral dUTPase and regulates its catalytic activity in infected cells.
Herpes Simplex
Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface.
Herpes Simplex
Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis.
Herpes Simplex
Herpes simplex virus type 1 latency-associated transcript inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels.
Herpes Simplex
Herpes simplex virus type 1 primary envelopment: UL34 protein modification and the US3-UL34 catalytic relationship.
Herpes Simplex
Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase.
Herpes Simplex
Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-? protein accumulation.
Herpes Simplex
Histone Deacetylase 1 and 2 are Phosphorylated at Novel Sites During Varicella Zoster Virus Infection.
Herpes Simplex
HSV-1 Hijacks the Host DNA Damage Response in Corneal Epithelial Cells through ICP4-Mediated Activation of ATM.
Herpes Simplex
HSV-1 Serine/Threonine Kinase US3 Hyperphosphorylates IRF3 and Inhibits the IFN-? production.
Herpes Simplex
HSV-I and the cellular DNA damage response.
Herpes Simplex
Identification of a physiological phosphorylation site of the herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells.
Herpes Simplex
Identification of a target protein of US3 protein kinase of herpes simplex virus type 2.
Herpes Simplex
Induction of strong antitumor immunity by an HSV-2-based oncolytic virus in a murine mammary tumor model.
Herpes Simplex
Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis.
Herpes Simplex
Interaction With 14-3-3 Correlates With Inactivation of the RIG-I Signalosome by Herpesvirus Ubiquitin Deconjugases.
Herpes Simplex
Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: Relevance to pathological-signalling cascades.
Herpes Simplex
Nuclear envelope impairment is facilitated by the herpes simplex virus 1 Us3 kinase.
Herpes Simplex
Persistent reversal of enhanced amphetamine intake by transient CaMKII inhibition.
Herpes Simplex
Protein kinase activities associated with the virions of pseudorabies and herpes simplex virus.
Herpes Simplex
Protein Kinase B/Akt Is Present in Activated Form throughout the Entire Replicative Cycle of {Delta}US3 Mutant Virus but Only at Early Times after Infection with Wild-Type Herpes Simplex Virus 1.
Herpes Simplex
Protein kinase D-dependent trafficking of the large Herpes simplex virus type 1 capsids from the TGN to plasma membrane.
Herpes Simplex
Regulation of the catalytic activity of herpes simplex virus 1 protein kinase Us3 by autophosphorylation and its role in pathogenesis.
Herpes Simplex
Role of herpes simplex virus 1 Us3 in viral neuroinvasiveness.
Herpes Simplex
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
Herpes Simplex
Role of the Herpes Simplex Virus 1 Us3 Kinase Phosphorylation Site and Endocytosis Motifs in Envelope Glycoprotein B in Its Intracellular Transport and Neurovirulence.
Herpes Simplex
Role of tyrosine kinases, protein kinase C, and protein kinase A in the regulation of interferon-alpha production induced by herpes simplex virus type 1.
Herpes Simplex
Specific interactions with TBP and TFIIB in vitro suggest that 14-3-3 proteins may participate in the regulation of transcription when part of a DNA binding complex.
Herpes Simplex
Subcellular localization of the US3 protein kinase of herpes simplex virus type 2.
Herpes Simplex
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Herpes Simplex
Targeted integration of functional human ATM cDNA into genome mediated by HSV/AAV hybrid amplicon vector.
Herpes Simplex
The 140-kDa RR1 protein from both HSV-1 and HSV-2 contains an intrinsic protein kinase activity capable of autophosphorylation but it is transphosphorylation defective.
Herpes Simplex
The herpes simplex virus 1 Us3 kinase is involved in assembly of membranes needed for viral envelopment and in distribution of glycoprotein K.
Herpes Simplex
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT).
Herpes Simplex
The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B.
Herpes Simplex
The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2.
Herpes Simplex
The nucleotidylylation of herpes simplex virus 1 regulatory protein alpha22 by human casein kinase II.
Herpes Simplex
The PK domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for immediate-early gene expression and virus growth.
Herpes Simplex
The transmembrane domain of the large subunit of HSV-2 ribonucleotide reductase (ICP10) is required for protein kinase activity and transformation-related signaling pathways that result in ras activation.
Herpes Simplex
The transmembrane helical segment but not the invariant lysine is required for the kinase activity of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10).
Herpes Simplex
The unique N terminus of herpes simplex virus type 1 ribonucleotide reductase large subunit is phosphorylated by casein kinase 2, which may have a homologue in Escherichia coli.
Herpes Simplex
The Us3 protein kinase of herpes simplex virus 1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad.
Herpes Simplex
The US3 protein kinase of herpes simplex virus type 2 is associated with phosphorylation of the UL12 alkaline nuclease in vitro.
Herpes Simplex
UL31 of herpes simplex virus 1 is necessary for optimal NF{kappa}B activation and expression of viral gene products.
Herpes Simplex
US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest.
Herpes Simplex
Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8(+) T cells.
Herpes Simplex
US3 of herpes simplex virus type 1 encodes a promiscuous protein kinase that phosphorylates and alters localization of lamin A/C in infected cells.
Herpes Simplex
US3 protein kinase of herpes simplex virus type 2 is required for the stability of the UL46-encoded tegument protein and its association with virus particles.
Herpes Simplex
Varicella-zoster virus ORF47 protein serine kinase: characterization of a cloned, biologically active phosphotransferase and two viral substrates, ORF62 and ORF63.
Herpes Simplex
Viral strategies for triggering and manipulating mitophagy.
Herpes Simplex
VZV ORF47 Serine Protein Kinase and Its Viral Substrates.
Herpes Simplex
[The role of cyclin-dependent protein kinase 2 in the replication of herpes simplex virus]
Herpes Zoster
A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding.
Herpes Zoster
Adrenocortical development: Lessons from mouse models.
Herpes Zoster
Baclofen inhibition of the hyperpolarization-activated cation current, Ih, in rat substantia nigra zona compacta neurons may be secondary to potassium current activation.
Herpes Zoster
Battle of the kinases: integration of adrenal responses to cAMP, DG and Ca2+ at the level of steroidogenic cytochromes P450 and 3betaHSD expression in H295R cells.
Herpes Zoster
Defective protein kinase A and C pathways are common causes of disordered zona pellucida (ZP)-induced acrosome reaction in normozoospermic infertile men with normal sperm-ZP binding.
Herpes Zoster
Histone Deacetylase 1 and 2 are Phosphorylated at Novel Sites During Varicella Zoster Virus Infection.
Herpes Zoster
Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II.
Herpes Zoster
Phosphorylation of the Nuclear Form of Varicella Zoster Virus Immediate-Early Protein 63 by Casein Kinase II at Serine 186.
Herpes Zoster
Quantitative proteomic reveals the dynamic of protein profile during final oocyte maturation in zebrafish.
Herpes Zoster
Selective Toll-Like Receptor 4 Antagonists Prevent Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice.
Herpesviridae Infections
Interaction With 14-3-3 Correlates With Inactivation of the RIG-I Signalosome by Herpesvirus Ubiquitin Deconjugases.
Hirschsprung Disease
Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity.
Histiocytoma, Malignant Fibrous
GTP binding controls complex formation by the human ROCO protein MASL1.
Histiocytosis
Clonal evolution of chronic lymphocytic leukemia to Langerhans cell histiocytosis: a case report.
Histiocytosis, Langerhans-Cell
Clonal evolution of chronic lymphocytic leukemia to Langerhans cell histiocytosis: a case report.
HIV Infections
A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.
HIV Infections
Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1.
HIV Infections
PknE, a serine/threonine protein kinase of Mycobacterium tuberculosis initiates survival crosstalk that also impacts HIV coinfection.
HIV Infections
Retraction: PknE, a Serine/Threonine Protein Kinase of Mycobacterium tuberculosis Initiates Survival Crosstalk That Also Impacts HIV Coinfection.
HIV Infections
Soluble Factors Secreted by Endothelial Cells Allow for Productive and Latent HIV-1 Infection in Resting CD4+ T cells.
HIV Infections
The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice.
Hodgkin Disease
c-JUN N-terminal kinase (JNK) is activated and contributes to tumor cell proliferation in classical Hodgkin lymphoma.
Hodgkin Disease
Epigenetic changes in the DAP-kinase CpG island in pediatric lymphoma.
Hodgkin Disease
Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease.
Holoprosencephaly
Fetal ethanol exposure activates protein kinase A and impairs Shh expression in prechordal mesendoderm cells in the pathogenesis of holoprosencephaly.
Huntington Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Huntington Disease
Architecture of population-differentiated polymorphisms in the human genome.
Huntington Disease
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.
Huntington Disease
Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.
Huntington Disease
Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.
Huntington Disease
Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation.
Huntington Disease
Increased oxidative stress and CaMKII activity contribute to electro-mechanical defects in cardiomyocytes from a murine model of Huntington's disease.
Huntington Disease
Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease.
Huntington Disease
Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.
Huntington Disease
Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease.
Huntington Disease
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention.
Huntington Disease
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Huntington Disease
Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders.
Huntington Disease
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
Hydrocephalus
Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus.
Hydrocephalus
Thrombin disrupts vascular endothelial-cadherin and leads to hydrocephalus via protease-activated receptors-1 pathway.
Hyperaldosteronism
Genomic structure of the human gene for protein kinase A regulatory subunit R1-beta (PRKAR1B) on 7p22: no evidence for mutations in familial hyperaldosteronism type II in a large affected kindred.
Hyperalgesia
A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.
Hyperalgesia
A role for adrenomedullin as a pain-related peptide in the rat.
Hyperalgesia
A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators.
Hyperalgesia
A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1.
Hyperalgesia
Acidosis Mediates the Switching of Gs-PKA and Gi-PKC? Dependence in Prolonged Hyperalgesia Induced by Inflammation.
Hyperalgesia
Activation of ATF3/AP-1 signaling pathway is required for P2X3-induced endometriosis pain.
Hyperalgesia
Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury.
Hyperalgesia
Activation of NMDA receptors leads to phosphorylation of TRPV1 S800 by protein kinase C and A-Kinase anchoring protein 150 in rat trigeminal ganglia.
Hyperalgesia
Activation of spinal Extacellular Signal-Regulated Kinases and c-jun N-terminal kinase signaling pathways contributes to morphine-induced acute and chronic hyperalgesia in mice.
Hyperalgesia
Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice.
Hyperalgesia
AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP (4) receptor/cyclic AMP pathway mediates prostaglandin E (2) -induced mechanical hyperalgesia.
Hyperalgesia
Astrocyte contributes to pain development via MMP2-JNK1/2 signaling in a mouse model of complex regional pain syndrome.
Hyperalgesia
c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity.
Hyperalgesia
Ca(2+) /calmodulin-dependent protein kinase II in spinal dorsal horn contributes to the pain hypersensitivity induced by ?-aminobutyric acid type a receptor inhibition.
Hyperalgesia
Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia.
Hyperalgesia
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy.
Hyperalgesia
Calcitonin gene-related peptide receptor activation produces PKA- and PKC-dependent mechanical hyperalgesia and central sensitization.
Hyperalgesia
Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury.
Hyperalgesia
CaMKII Phosphorylation in Primary Somatosensory Cortical Neurons is Involved in the Inhibition of Remifentanil-induced Hyperalgesia by Lidocaine in Male Sprague-Dawley Rats.
Hyperalgesia
CaMKII? underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice.
Hyperalgesia
Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways.
Hyperalgesia
CFTR mediates noradrenaline-induced ATP efflux from DRG neurons.
Hyperalgesia
Change in prostaglandin signaling during sickness syndrome hyperalgesia after ovariectomy in female rats.
Hyperalgesia
Changes of calcium/calmodulin-dependent protein kinase II expression in dorsal root ganglia during maturation in long-term diabetes.
Hyperalgesia
Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2.
Hyperalgesia
Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways.
Hyperalgesia
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.
Hyperalgesia
Contribution of Ca(2+) -dependent protein kinase C in the spinal cord to the development of mechanical allodynia in diabetic mice.
Hyperalgesia
Diabetes-Induced Mechanical Hyperalgesia Involves Spinal Mitogen-Activated Protein Kinase Activation in Neurons and Microglia via N-Methyl-D-aspartate-Dependent Mechanisms.
Hyperalgesia
Different peripheral mechanisms mediate enhanced nociception in metabolic/toxic and traumatic painful peripheral neuropathies in the rat.
Hyperalgesia
Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors.
Hyperalgesia
Differential involvement of spinal protein kinase C and protein kinase A in neuropathic and inflammatory pain in mice.
Hyperalgesia
Differential regulation of peripheral IL-1?-induced mechanical allodynia and thermal hyperalgesia in rats.
Hyperalgesia
Down-regulation of HTR1A-modulated ACC activation contributes to stress-induced visceral hyperalgesia in rats.
Hyperalgesia
Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt.
Hyperalgesia
Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats.
Hyperalgesia
ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.
Hyperalgesia
Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation.
Hyperalgesia
Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia.
Hyperalgesia
Functional interactions between NMDA receptors and TRPV1 in trigeminal sensory neurons mediate mechanical hyperalgesia in the rat masseter muscle.
Hyperalgesia
Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming.
Hyperalgesia
GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia.
Hyperalgesia
Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel.
Hyperalgesia
In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons.
Hyperalgesia
Inhibition of Ca2+/calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in rats.
Hyperalgesia
Inhibition of protein phosphatases alters the expression of morphine tolerance in mice.
Hyperalgesia
Inhibition of the cyclic adenosine monophosphate pathway attenuates neuropathic pain and reduces phosphorylation of cyclic adenosine monophosphate response element-binding in the spinal cord after partial sciatic nerve ligation in rats.
Hyperalgesia
Interleukin-17A Acts to Maintain Neuropathic Pain Through Activation of CaMKII/CREB Signaling in Spinal Neurons.
Hyperalgesia
Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1.
Hyperalgesia
Intrathecal injection of KN93 attenuates paradoxical remifentanil-induced postoperative hyperalgesia by inhibiting spinal CaMKII phosphorylation in rats.
Hyperalgesia
Intrathecal Raf-1-selective siRNA attenuates sustained morphine-mediated thermal hyperalgesia.
Hyperalgesia
Involvement of spinal phosphorylation cascade of Tyr1472-NR2B, Thr286-CaMKII, and Ser831-GluR1 in neuropathic pain.
Hyperalgesia
Is there more than one prostaglandin E receptor subtype mediating hyperalgesia in the rat hindpaw?
Hyperalgesia
Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats.
Hyperalgesia
Marked sexual dimorphism in 5-HT1 receptors mediating pronociceptive effects of sumatriptan.
Hyperalgesia
MCP-1 stimulates spinal microglia via PI3K/Akt pathway in bone cancer pain.
Hyperalgesia
Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice.
Hyperalgesia
Mechanosensitive ion channels in cultured sensory neurons of neonatal rats.
Hyperalgesia
Multiple second messenger systems act sequentially to mediate rolipram-induced prolongation of prostaglandin E2-induced mechanical hyperalgesia in the rat.
Hyperalgesia
NF-?B, ERK, p38 MAPK and JNK contribute to the initiation and/or maintenance of mechanical allodynia induced by tumor necrosis factor-alpha in the red nucleus.
Hyperalgesia
Perturbing NR2B-PSD-95 interaction relieves neuropathic pain by inactivating CaMKII-CREB signaling.
Hyperalgesia
Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia.
Hyperalgesia
Phosphorylated CaMKII levels increase in rat central nervous system after large-dose intravenous remifentanil.
Hyperalgesia
Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections.
Hyperalgesia
Prevention of Remifentanil Induced Postoperative Hyperalgesia by Dexmedetomidine via Regulating the Trafficking and Function of Spinal NMDA Receptors as well as PKC and CaMKII Level In Vivo and In Vitro.
Hyperalgesia
Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia.
Hyperalgesia
Pulsed radiofrequency reduced complete Freund's adjuvant-induced mechanical hyperalgesia via the spinal c-Jun N-terminal kinase pathway.
Hyperalgesia
Real-Time Translocation and Function of PKC?II Isoform in Response to Nociceptive Signaling via the TRPV1 Pain Receptor.
Hyperalgesia
Repeated intrathecal administration of ropivacaine causes neurotoxicity in rats.
Hyperalgesia
Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain.
Hyperalgesia
Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II.
Hyperalgesia
Role of protein kinase A in the maintenance of inflammatory pain.
Hyperalgesia
Role of the sensory neuron cytoskeleton in second messenger signaling for inflammatory pain.
Hyperalgesia
Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia.
Hyperalgesia
Severity of alcohol-induced painful peripheral neuropathy in female rats: role of estrogen and protein kinase (A and Cepsilon).
Hyperalgesia
Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat.
Hyperalgesia
Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy.
Hyperalgesia
Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat.
Hyperalgesia
Silencing of spinal Trpv1 attenuates neuropathic pain in rats by inhibiting CAMKII expression and ERK2 phosphorylation.
Hyperalgesia
Sonic Hedgehog Signaling Contributes to Chronic Post-Thoracotomy Pain via Activating BDNF/TrkB Pathway in Rats.
Hyperalgesia
Spinal injection of TNF-?-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1.
Hyperalgesia
Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming.
Hyperalgesia
Suppressed Ca2+/CaM/CaMKII-dependent KATP channel activity in primary afferent neurons mediates hyperalgesia after axotomy.
Hyperalgesia
Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA.
Hyperalgesia
Sympathetic-independent bradykinin mechanical hyperalgesia induced by subdiaphragmatic vagotomy in the rat.
Hyperalgesia
The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin.
Hyperalgesia
The Mechanism of Hyperalgesia and Anxiety Induced by Remifentanil: Phosphorylation of GluR1 Receptors in the Anterior Cingulate Cortex.
Hyperalgesia
trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder.
Hyperalgesia
Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain.
Hyperalgesia
TRPV1 channel contributes to remifentanil-induced postoperative hyperalgesia via regulation of NMDA receptor trafficking in dorsal root ganglion.
Hyperalgesia
[EXPRESS] Enhancement of spinal dorsal horn neuron NMDA receptor phosphorylation as the mechanism of remifentanil induced hyperalgesia: Roles of PKC and CaMKII.
Hyperandrogenism
A Single Nucleotide Polymorphism in STK11 Influences Insulin Sensitivity and Metformin Efficacy in Hyperinsulinemic Girls with Androgen Excess.
Hyperandrogenism
Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome.
Hyperandrogenism
Nonhuman primates as models for human adrenal androgen production: Function and dysfunction.
Hyperandrogenism
The regulation of human p450c17 activity: relationship to premature adrenarche, insulin resistance and the polycystic ovary syndrome.
Hypercholesterolemia
Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice.
Hyperglycemia
Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia.
Hyperglycemia
Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles.
Hyperglycemia
Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.
Hyperglycemia
Altered expression of O-GlcNAc-modified proteins in a mouse model whose glycemic status is controlled by a low carbohydrate ketogenic diet.
Hyperglycemia
Alzheimer's and Hyperglycemia: Role of the Insulin Signaling Pathway and GSK-3 Inhibition in Paving a Path to Dementia.
Hyperglycemia
Antagonist of thromboxane A2 receptor by SQ29548 lowers DOCA-induced hypertension in diabetic rats.
Hyperglycemia
Anti-inflammatory Potential of GSK-3 Inhibitors.
Hyperglycemia
Antioxidant Effects of Oral Ang-(1-7) Restore Insulin Pathway and RAS Components Ameliorating Cardiometabolic Disturbances in Rats.
Hyperglycemia
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.
Hyperglycemia
Bamboo leaf extract ameliorates diabetic nephropathy through activating the AKT signaling pathway in rats.
Hyperglycemia
Beta Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes.
Hyperglycemia
Blockade of c-Jun N-terminal kinase activation abrogates hyperglycemia-induced yolk sac vasculopathy in vitro.
Hyperglycemia
CaMKII in sinoatrial node physiology and dysfunction.
Hyperglycemia
CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia.
Hyperglycemia
CHIP-overexpressing Wharton's jelly-derived mesenchymal stem cells attenuate hyperglycemia-induced oxidative stress-mediated kidney injuries in diabetic rats.
Hyperglycemia
Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic ?-cells via protein kinase A.
Hyperglycemia
Dietary Methionine Restriction Alleviates Hyperglycemia in Pigs with Intrauterine Growth Restriction by Enhancing Hepatic Protein Kinase B Signaling and Glycogen Synthesis.
Hyperglycemia
Differential early mitogen-activated protein kinase activation in hyperglycemic ischemic brain injury in the rat.
Hyperglycemia
Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis.
Hyperglycemia
Effect of Imipramine, Paroxetine, and Lithium Carbonate on Neurobehavioral Changes of Streptozotocin in Rats: Impact on Glycogen Synthase Kinase-3 and Blood Glucose Level.
Hyperglycemia
Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro.
Hyperglycemia
Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats.
Hyperglycemia
Effects of pomegranate aril juice and its punicalagin on some key regulators of insulin resistance and oxidative liver injury in streptozotocin-nicotinamide type 2 diabetic rats.
Hyperglycemia
Effects of PPAR-gamma knock-down and hyperglycemia on insulin signaling in vascular smooth muscle cells from hypertensive rats.
Hyperglycemia
Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells.
Hyperglycemia
Enhancement of Cellular Antioxidant-Defence Preserves Diastolic Dysfunction via Regulation of Both Diastolic Zn(2+) and Ca(2+) and Prevention of RyR2-Leak in Hyperglycemic Cardiomyocytes.
Hyperglycemia
Epigallocatechin-3-gallate ameliorates hyperglycemia-induced embryonic vasculopathy and malformation by inhibition of Foxo3a activation.
Hyperglycemia
Exaggerated activities of TRPM7 underlie bupivacaine-induced neurotoxicity in the SH-SY5Y cells preconditioned with high glucose.
Hyperglycemia
Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance.
Hyperglycemia
Gallic acid ameliorates renal functions by inhibiting the activation of p38 MAPK in experimentally induced type 2 diabetic rats and cultured rat proximal tubular epithelial cells.
Hyperglycemia
HIPK2 role in the tumor-host interaction: Impact on fibroblasts transdifferentiation CAF-like.
Hyperglycemia
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes.
Hyperglycemia
Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex.
Hyperglycemia
Hyperglycemia decreases expression of 14-3-3 proteins in an animal model of stroke.
Hyperglycemia
Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the Akt survival pathway.
Hyperglycemia
Hyperglycemia induces inducible nitric oxide synthase gene expression and consequent nitrosative stress via c-Jun N-terminal kinase activation.
Hyperglycemia
Hyperglycemia Induces Osteoclastogenesis and Bone Destruction Through the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II.
Hyperglycemia
Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways.
Hyperglycemia
Hyperglycemia triggers HIPK2 protein degradation.
Hyperglycemia
Hyperglycemia via activation of thromboxane A2 receptor impairs the integrity and function of blood-brain barrier in microvascular endothelial cells.
Hyperglycemia
Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.
Hyperglycemia
JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis.
Hyperglycemia
Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.
Hyperglycemia
MicroRNA 375 modulates hyperglycemia-induced enteric glial cell apoptosis and Diabetes-induced gastrointestinal dysfunction by targeting Pdk1 and repressing PI3K/Akt pathway.
Hyperglycemia
miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle.
Hyperglycemia
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells.
Hyperglycemia
Mizoribine-induced severe hyperglycemia in a patient with microscopic polyangiitis.
Hyperglycemia
Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity.
Hyperglycemia
Photobiomodulation therapy ameliorates hyperglycemia and insulin resistance by activating cytochrome c oxidase-mediated protein kinase B in muscle.
Hyperglycemia
Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetic rats.
Hyperglycemia
Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power.
Hyperglycemia
Rho kinase/AMPK axis regulates hepatic lipogenesis during overnutrition.
Hyperglycemia
RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose.
Hyperglycemia
Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes.
Hyperglycemia
Second messenger and cAMP-dependent protein kinase responses to dehydration and anoxia stresses in frogs.
Hyperglycemia
Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet-fed mice.
Hyperglycemia
The Role of Acute Hyperglycemia on the Risk of Malignant Arrhythmia in Acute Myocardial Infarction Patients: A Study of Myocardial Damage, Ion Channel Changes and Inflammatory Factors.
Hyperglycemia
Time-dependent impairments in learning and memory in Streptozotocin-induced hyperglycemic rats.
Hyperglycemia
Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis.
Hyperglycemia
[Kinetic studies of protein kinase A in rat liver during early sepsis]
Hyperhomocysteinemia
Beneficial effect of insulin in hyperhomocysteinemia and diabetes mellitus-induced vascular endothelium dysfunction: role of phosphoinositide dependent kinase and protein kinase B.
Hyperhomocysteinemia
Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia.
Hyperhomocysteinemia
Dyrk1A, a Serine/Threonine Kinase, is Involved in ERK and Akt Activation in the Brain of Hyperhomocysteinemic Mice.
Hyperhomocysteinemia
Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice.
Hyperhomocysteinemia
Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats.
Hyperinsulinism
Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin.
Hyperinsulinism
Crosstalk of Diabetic Conditions with Static Versus Dynamic Flow Environment-Impact on Aortic Valve Remodeling.
Hyperinsulinism
Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders.
Hyperinsulinism
Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.
Hyperinsulinism
Effects of hyperinsulinemia on acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor via the PI3K/AKT pathway in non-small cell lung cancer cells in vitro.
Hyperinsulinism
Estrogen-progestin oral contraceptive and nicotine exposure synergistically confers cardio-renoprotection in female Wistar rats.
Hyperinsulinism
Impact of insulin and glucocorticoid signalling on hepatic glucose homeostasis in the rat exposed to high-fructose diet and chronic stress.
Hyperinsulinism
Insulin resistance and Alzheimer's disease: molecular links & clinical implications.
Hyperinsulinism
Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition.
Hyperinsulinism
Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.
Hyperinsulinism
Mechanism for the synergistic effect of rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B.
Hyperinsulinism
Physiological hyperinsulinemia stimulates p70(S6k) phosphorylation in human skeletal muscle.
Hyperinsulinism
Regulation of glycogen synthase kinase-3 in human skeletal muscle: effects of food intake and bicycle exercise.
Hyperinsulinism
Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet-fed mice.
Hyperinsulinism
Targeted disruption of ROCK1 causes insulin resistance in vivo.
Hyperinsulinism
The high-fat-fed lean Zucker rat: a spontaneous isocaloric model of fat-induced insulin resistance associated with muscle GSK-3 overactivity.
Hyperinsulinism
Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle.
Hyperkalemia
Dietary salt modulates the sodium chloride cotransporter expression likely through an aldosterone-mediated WNK4-ERK1/2 signaling pathway.
Hyperkalemia
Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
Hyperkalemia
Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF.
Hyperkalemia
Effect of age and affection status on blood pressure, serum potassium and stature in familial hyperkalaemia and hypertension.
Hyperkalemia
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.
Hyperkalemia
Resolution of hypertension during pregnancy in familial hyperkalemia and hypertension with the WNK4 Q565E mutation.
Hyperkalemia
WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.
Hyperkalemia
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.
Hyperkinesis
Protein kinase A signalling in Schistosoma mansoni cercariae and schistosomules.
Hyperlipidemias
Berberine up-regulates hepatic low-density lipoprotein receptor through Ras-independent but AMP-activated protein kinase-dependent Raf-1 activation.
Hyperlipidemias
Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia.
Hyperlipidemias
CaMKII activation promotes cardiac electrical remodeling and increases the susceptibility to arrhythmia induction in high fat diet-fed mice with hyperlipidemia conditions.
Hyperlipidemias
CaMKII Activation Promotes Cardiac Electrical Remodeling and Increases the Susceptibility to Arrhythmia Induction in High-fat Diet-Fed Mice With Hyperlipidemia Conditions: Erratum.
Hyperlipidemias
Effect of methanol extract of Schisandrae Fructus on high fat diet induced hyperlipidemic mice.
Hyperlipidemias
Guduchi Sawras (Tinospora cordifolia): An Ayurvedic drug treatment modulates the impaired lipid metabolism in alcoholics through dopaminergic neurotransmission and anti-oxidant defense system.
Hyperlipidemias
Role of CaMKII in free fatty acid/hyperlipidemia-induced cardiac remodeling both in vitro and in vivo.
Hyperlipidemias
Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic ?-cell survival and function via CREB.
Hyperparathyroidism
The OPG/RANKL/RANK system in metabolic bone diseases.
Hyperparathyroidism, Primary
Calmodulin and calmodulin-dependent protein kinase II (CaMKII) inhibit hormone secretion in human parathyroid adenoma.
Hyperparathyroidism, Primary
Increased protein kinase A type I? regulatory subunit expression in parathyroid gland adenomas of patients with primary hyperparathyroidism.
Hyperpigmentation
Mechanisms of melanogenesis inhibition by 2,5-dimethyl-4-hydroxy-3(2H)-furanone.
Hyperpigmentation
The regulation of protein kinase casein kinase II by apigenin is involved in the inhibition of ultraviolet B-induced macrophage migration inhibitory factor-mediated hyperpigmentation.
Hyperprolactinemia
Efficacy and Mechanism of Action of Yiru Tiaojing Granule Against Hyperprolactinemia In Vitro and In Vivo.
Hyperprolactinemia
Stimulatory effects of hyperprolactinemia on aldosterone secretion in ovariectomized rats.
Hypersensitivity
ABI1 and PP2CA phosphatases are negative regulators of Snf1-related protein kinase1 signaling in Arabidopsis.
Hypersensitivity
Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin.
Hypersensitivity
Activation of the RAS/B-RAF-MEK-ERK pathway in satellite glial cells contributes to substance p-mediated orofacial pain.
Hypersensitivity
Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.
Hypersensitivity
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.
Hypersensitivity
ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions.
Hypersensitivity
Biochemical and genetic analyses of the role of yeast casein kinase 2 in salt tolerance.
Hypersensitivity
Budding yeast 14-3-3 proteins contribute to the robustness of the DNA damage and spindle checkpoints.
Hypersensitivity
c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity.
Hypersensitivity
Cancer risk from low dose radiation in Ptch1+/- mice with inactive DNA repair systems: Therapeutic implications for medulloblastoma.
Hypersensitivity
Casein Kinase II Inhibition Reverses Pain Hypersensitivity and Potentiated Spinal N-Methyl-D-aspartate Receptor Activity Caused by Calcineurin Inhibitor.
Hypersensitivity
Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury.
Hypersensitivity
Characterization of the promoter region, first ten exons and nine intron-exon boundaries of the DNA-dependent protein kinase catalytic subunit gene, DNA-PKcs (XRCC7).
Hypersensitivity
Chemokine receptor CXCR4 regulates CaMKII/CREB pathway in spinal neurons that underlies cancer-induced bone pain.
Hypersensitivity
Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.
Hypersensitivity
Different Roles of Peripheral Mitogen-Activated Protein Kinases in Carrageenan-Induced Arthritic Pain and Arthritis in Rats.
Hypersensitivity
Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors.
Hypersensitivity
Differential roles of spinal protein kinases C and a in development of primary heat and mechanical hypersensitivity induced by subcutaneous bee venom chemical injury in the rat.
Hypersensitivity
Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice.
Hypersensitivity
Extracellular signal-regulated kinases mediate melittin-induced hypersensitivity of spinal neurons to chemical and thermal but not mechanical stimuli.
Hypersensitivity
Functions of Saccharomyces cerevisiae 14-3-3 proteins in response to DNA damage and to DNA replication stress.
Hypersensitivity
HUS1 regulates in vivo responses to genotoxic chemotherapies.
Hypersensitivity
Identification and Characterization of a Small Inhibitory Peptide That Can Target DNA-PKcs Autophosphorylation and Increase Tumor Radiosensitivity.
Hypersensitivity
Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.
Hypersensitivity
Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock.
Hypersensitivity
Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3beta constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines.
Hypersensitivity
Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity.
Hypersensitivity
Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling.
Hypersensitivity
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Hypersensitivity
Loss of ypk1 function causes rapamycin sensitivity, inhibition of translation initiation and synthetic lethality in 14-3-3-deficient yeast.
Hypersensitivity
Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.
Hypersensitivity
Nerve growth factor mediates a switch in intracellular signaling for PGE2-induced sensitization of sensory neurons from protein kinase A to Epac.
Hypersensitivity
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Hypersensitivity
Overexpression of glycogen synthase kinase 3beta sensitizes neuronal cells to ethanol toxicity.
Hypersensitivity
Overexpression of the RI alpha subunit of protein kinase A confers hypersensitivity to topoisomerase II inhibitors and 8-chloro-cyclic adenosine 3'5'-monophosphate in Chinese hamster ovary cells.
Hypersensitivity
Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach.
Hypersensitivity
Protein kinase D1 is essential for the proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic actinomycetes Saccharopolyspora rectivirgula.
Hypersensitivity
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
Hypersensitivity
Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling.
Hypersensitivity
Regulation of Glucose Transport by ROCK1 Differs from That of ROCK2 and Is Controlled by Actin Polymerization.
Hypersensitivity
Regulation of the firing activity by PKA-PKC-Src family kinases in cultured neurons of hypothalamic arcuate nucleus.
Hypersensitivity
Spinal IL-36?/IL-36R participates in the maintenance of chronic inflammatory pain through astroglial JNK pathway.
Hypersensitivity
Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity.
Hypersensitivity
Stimulation of spinal dorsal horn ?2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase.
Hypersensitivity
Targeting Raf-1 gene expression by a DNA enzyme inhibits juvenile myelomonocytic leukemia cell growth.
Hypersensitivity
The Arabidopsis MERISTEM DISORGANIZATION1 gene is required for maintenance of stem cells through reduction of the DNA damage level.
Hypersensitivity
The Arabidopsis SR45 Splicing Factor, a Negative Regulator of Sugar Signaling, Modulates SNF1-Related Protein Kinase 1 Stability.
Hypersensitivity
The Immuno-Enhancement Effects of Tubiechong (Eupolyphaga sinensis) Lyophilized Powder in Cyclophosphamide-Induced Immunosuppressed Mice.
Hypersensitivity
The p38 pathway partially mediates caspase-3 activation induced by reactive oxygen species in Fanconi anemia C cells.
Hypersensitivity
Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
Hypersensitivity
Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population.
Hypersensitivity
Wnt5b/Ryk-mediated membrane trafficking of P2X3 receptors contributes to bone cancer pain.
Hypertension
A functional variant in the serine-threonine kinase coding gene is associated with hypertension: a case-control study in a Finnish population, the Tampere adult population cardiovascular risk study.
Hypertension
A new methodology for quantification of alternatively spliced exons reveals a highly tissue-specific expression pattern of WNK1 isoforms.
Hypertension
A novel protein kinase signaling pathway essential for blood pressure regulation in humans.
Hypertension
Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
Hypertension
Association between Serine/Threonine Kinase 39 Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans.
Hypertension
Association of with-no-lysine kinase 1 and Serine/Threonine kinase 39 gene polymorphisms and haplotypes with essential hypertension in Tibetans.
Hypertension
Ataxia-Telangiectasia Mutated (ATM) Protein Signaling Participates in Development of Pulmonary Arterial Hypertension in Rats.
Hypertension
Baicalin prevents pulmonary arterial remodeling in vivo via the AKT/ERK/NF-?B signaling pathways.
Hypertension
Beneficial Effect of a Multistrain Synbiotic Prodefen® Plus on the Systemic and Vascular Alterations Associated with Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide Synthase and Protein Kinase A.
Hypertension
Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3/CamKII dependent pathway.
Hypertension
Calcium- and protein kinase C-dependent basal tone in the aorta of hypertensive rats.
Hypertension
Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function.
Hypertension
Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy.
Hypertension
CaMKII Regulates Synaptic NMDA Receptor Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension.
Hypertension
Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension.
Hypertension
Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule.
Hypertension
Cerebrovascular damage after midlife transient hypertension in non-transgenic and Alzheimer's disease rats.
Hypertension
Checkpoint Kinase 1 Promotes the Development of Pulmonary Arterial Hypertension.
Hypertension
Chloride sensing by WNK1 involves inhibition of autophosphorylation.
Hypertension
Common variants of ROCKs and the risk of hypertension, and stroke: Two case-control studies and a follow-up study in Chinese Han population.
Hypertension
Concerted actions of NHERF2 and WNK4 in regulating TRPV5.
Hypertension
Crosstalk between phosphorylation and ubiquitination is involved in high salt-induced WNK4 expression.
Hypertension
Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension.
Hypertension
Dietary salt modulates the sodium chloride cotransporter expression likely through an aldosterone-mediated WNK4-ERK1/2 signaling pathway.
Hypertension
Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
Hypertension
Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF.
Hypertension
Dysfunction of paracellin-1 by dephosphorylation in Dahl salt-sensitive hypertensive rats.
Hypertension
Effect of age and affection status on blood pressure, serum potassium and stature in familial hyperkalaemia and hypertension.
Hypertension
Effects of p38 MAPK Inhibitor on angiotensin II-dependent hypertension, organ damage, and superoxide anion production.
Hypertension
Endogenous casein kinase-1 modulates NMDA receptor activity of hypothalamic presympathetic neurons and sympathetic outflow in hypertension.
Hypertension
eNOS, NO, and the activation of ERK and AKT signaling at mid-gestation and near-term in an ovine model of intrauterine growth restriction.
Hypertension
G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese.
Hypertension
Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways.
Hypertension
Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice.
Hypertension
High glucose promotes vascular smooth muscle cell proliferation by upregulating proto-oncogene serine/threonine-protein kinase Pim-1 expression.
Hypertension
Human with-no-lysine kinase-4 3'-UTR acting as the enhancer and being targeted by miR-296.
Hypertension
Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.
Hypertension
Insulin Signaling, GSK-3, Heat Shock Proteins and the Natural History of Type 2 Diabetes Mellitus: A Hypothesis.
Hypertension
Interactive contribution of serine/threonine kinase 39 gene multiple polymorphisms to hypertension among northeastern Han Chinese.
Hypertension
Is renal ß-adrenergic-WNK4-NCC pathway important in salt hypertension of Dahl rats?
Hypertension
Kinase drug discovery--what's next in the field?
Hypertension
Lack of association between STK39 and hypertension in the Chinese population.
Hypertension
Local angiotensin II aggravates cardiac remodeling in hypertension.
Hypertension
Lower cardiovagal tone and baroreflex sensitivity associated with hepatic insulin resistance and promote cardiovascular disorders in Tibetan minipigs induced by a high fat and high cholesterol diet.
Hypertension
Metabolic syndrome does not influence the phenotype of LRRK2 and GBA related Parkinson's disease.
Hypertension
Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress.
Hypertension
MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats.
Hypertension
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform.
Hypertension
OS 15-01 ASSOCIATION OF CARDIAC (P) RR AND PLC-b3 EXPRESSION IN RATS WITH AORTIC CONSTRICTION.
Hypertension
OS 32-07 LEVOROTATORY-AMLODIPINE PLUS FLUVASTATIN CONFER ADDITIVE EFFECTS ON RETARDING ENDOTHELIUM-MESENCHYMAL TRANSITION THROUGH SUPPRESSING ROCK1 EXPRESSION.
Hypertension
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.
Hypertension
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
Hypertension
PI3-kinase-induced hyperreactivity in DOCA-salt hypertension is independent of GSK-3 activity.
Hypertension
Protein kinase CK2 contributes to diminished small conductance Ca2+-activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension.
Hypertension
Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension.
Hypertension
Redox-sensitive calcium/calmodulin-dependent protein kinase II? in angiotensin II intra-neuronal signaling and hypertension.
Hypertension
Resolution of hypertension during pregnancy in familial hyperkalemia and hypertension with the WNK4 Q565E mutation.
Hypertension
Resveratrol Regulates Blood Pressure by Enhancing AMPK Signaling to Downregulate a Rac1-Derived NADPH Oxidase in the Central Nervous System.
Hypertension
Rice WNK1 is regulated by abiotic stress and involved in internal circadian rhythm.
Hypertension
ROCK1 feedback regulation of the upstream small GTPase RhoA.
Hypertension
ROCK2 allelic variants are not associated with preeclampsia susceptibility in the Finnish population.
Hypertension
Role of alpha2-adrenergic receptors and cyclic adenosine monophosphate-dependent protein kinase in the regulation of norepinephrine release in the central nervous system of spontaneously hypertensive rats.
Hypertension
Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension.
Hypertension
Role of CaMKII in Ang-II-dependent small artery remodeling.
Hypertension
Sequencing of mutations in the serine/threonine kinase domain of the bone morphogenetic protein receptor type 2 gene causing pulmonary arterial hypertension.
Hypertension
Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.
Hypertension
Serine/threonine kinase 39 is a candidate gene for primary hypertension especially in women: results from two cohort studies in Swedes.
Hypertension
Solution Structure of the WNK1 Autoinhibitory Domain, a WNK-Specific PF2 Domain.
Hypertension
STK39, overexpressed in osteosarcoma, regulates osteosarcoma cell invasion and proliferation.
Hypertension
Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.
Hypertension
Whole transcriptome analysis of adrenal glands from prenatal glucocorticoid programmed hypertensive rodents.
Hypertension
WNK Protein Kinases Modulate Cellular Cl- Flux by Altering the Phosphorylation State of the Na-K-Cl and K-Cl Cotransporters.
Hypertension
WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.
Hypertension
WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.
Hypertension
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.
Hypertension
WNK4-mediated regulation of renal ion transport proteins.
Hypertension
[Lentiviral vectors carrying siRNA inhibit S1PR3 gene expression in the corpus cavernosum smooth muscle cells of rats with spontaneous hypertension].
Hypertension, Pulmonary
Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.
Hypertension, Pulmonary
Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice.
Hypertension, Pulmonary
Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 ? in neonatal rats.
Hypertension, Pulmonary
Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension.
Hypertension, Pulmonary
Inhibition of Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 (MK2) is Protective in Pulmonary Hypertension.
Hypertension, Pulmonary
Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension.
Hypertension, Pulmonary
Retracted: Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension, by I Morecroft, B Doyle, M Nilsen, W Kolch, K Mair and MR MacLean. British Journal of Pharmacology, volume 163(5): 948-963, published in June 2011; DOI 10.1111/j.1476-5381.2011.01305.x.
Hypertension, Pulmonary
The level of ROCK1 and ROCK2 in patients with pulmonary hypertension in plateau area.
Hyperthyroidism
Mechanism of hyperthyroidism-induced modulation of the L-type Ca2+ current in guinea pig ventricular myocytes.
Hyperthyroidism
Redox status and pro-survival/pro-apoptotic protein expression in the early cardiac hypertrophy induced by experimental hyperthyroidism.
Hyperthyroidism
The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism.
Hyperthyroidism
Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation.
Hyperthyroidism
Thyroid hormones increase the contractility but suppress the effects of beta-adrenergic agonist by decreasing phospholamban expression in rat atria.
Hypertrophy, Left Ventricular
2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.
Hypertrophy, Left Ventricular
IGF-2R-G?q signalling and cardiac hypertrophy in the low birth weight lamb.
Hypertrophy, Left Ventricular
Na+ channel regulation by Ca2+/Calmodulin and Ca2+/Calmodulin-dependent Protein Kinase II in Guinea-pig Ventricular Myocytes.
Hypertrophy, Left Ventricular
[Effects of simvastatin on the left ventricular hypertrophy in spontaneously hypertensive rats and its relationship with the expression of protein kinase B]
Hypertrophy, Right Ventricular
Galectin-3 aggravates pulmonary arterial hypertension via immunomodulation in congenital heart disease.
Hypertrophy, Right Ventricular
[The role of endoplasmic reticulum stress in pulmonary hypertension in rat induced by chronic hypoxia and hypercapnia].
Hypocalcemia
Neonatal hypocalcemic seizures in siblings exposed to topiramate in utero.
Hypoglossal Nerve Injuries
Enhanced expression of 14-3-3 family members in injured motoneurons.
Hypoglossal Nerve Injuries
Morphological changes and expression of protein kinase CK2 beta subunit in the microglia after hypoglossal nerve transection.
Hypoglycemia
Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.
Hypoglycemia
Hypoglycemia enhances the expression of prion protein and heat-shock protein 70 in a mouse neuroblastoma cell line.
Hypoglycemia
Persistent translocation and inhibition of Ca2+/calmodulin-dependent protein kinase II in the crude synaptosomal fraction of the vulnerable hippocampus following hypoglycemia.
Hypoglycemia
Signaling pathways involved in thrombin-induced cell protection.
Hypogonadism
Male hypogonadism in myotonic dystrophy is related to (CTG)n triplet mutation.
Hypokalemia
Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation.
Hypokinesia
Identification of Three Novel LRRK2 Mutations associated with Parkinson's Disease in a Calabrian Population.
Hypokinesia
Parkinsonian phenotype in Machado-Joseph disease (MJD/SCA3): a two-case report.
Hypokinesia
Targeting the cannabinoid CB2 receptor to attenuate the progression of motor deficits in LRRK2-transgenic mice.
Hypokinesia
The discovery of LRRK2 p.R1441S, a novel mutation for Parkinson's disease, adds to the complexity of a mutational hotspot.
Hypoparathyroidism
Neonatal hypocalcemic seizures in siblings exposed to topiramate in utero.
Hypopigmentation
A derivative of imidazobenzimidazole, ML106, inhibits melanin synthesis via p38 MAPK activation.
Hypopigmentation
Nobiletin, a Polymethoxy Flavonoid, Reduced Endothelin-1 Plus SCF-Induced Pigmentation in Human Melanocytes.
Hypospadias
c-Jun N-terminal kinase is upregulated in patients with hypospadias.
Hypotension
A selective Akt inhibitor produces hypotension and bradycardia in conscious rats due to inhibition of the autonomic nervous system.
Hypotension
Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats.
Hypotension
B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension.
Hypotension
Glucagon Protects Against Impaired NMDA-Mediated Cerebrovasodilation and Cerebral Autoregulation during Hypotension after Brain Injury by Activating cAMP Protein Kinase A and Inhibiting Upregulation of tPA.
Hypotension
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase b/akt inhibitors with reduced hypotension.
Hypothyroidism
Comparison of Effects of Spatial and Non-Spatial Memory Acquisition on the CaMKII Pathway During Hypothyroidism and Nicotine Treatment.
Hypothyroidism
Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression.
Hypothyroidism
Developmental Iodine Deficiency and Hypothyroidism Impair Spatial Memory in Adolescent Rat Hippocampus: Involvement of CaMKII, Calmodulin and Calcineurin.
Hypothyroidism
Developmental Iodine Deficiency and Hypothyroidism Reduce Phosphorylation of Calcium/Calmodulin-Dependent Kinase II in the Rat Entorhinal Cortex.
Hypothyroidism
Effect of hypothyroidism and thyroid hormone replacement on the level of protein kinase C and protein kinase A in rat liver.
Hypothyroidism
Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats.
Hypothyroidism
Molecular studies on the protective effect of nicotine in adult-onset hypothyroidism-induced impairment of long-term potentiation.
Hypothyroidism
Role of phosphorylated CaMKII and calcineurin in the differential effect of hypothyroidism on LTP of CA1 and dentate gyrus.
Hypoxia, Brain
Binding studies and biological evaluation of ?-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV.
Hypoxia, Brain
Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Hypoxia, Brain
Suppression of PDGF induces neuronal apoptosis after neonatal cerebral hypoxia and ischemia by inhibiting P-PI3K and P-AKT signaling pathways.
Hypoxia, Brain
Synthesis and biological evaluation of novel 5,6-dihydropyrimido[4,5-f]quinazoline derivatives as potent CDK2 inhibitors.
Hypoxia-Ischemia, Brain
Limited role of the c-Jun N-terminal kinase pathway in a neonatal rat model of cerebral hypoxia-ischemia.
Hypoxia-Ischemia, Brain
Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats are associated with increased expression of GDNF-RET and protein kinase B.
Idiopathic Pulmonary Fibrosis
Clinical significance of mTOR, ZEB1, ROCK1 expression in lung tissues of pulmonary fibrosis patients.
Idiopathic Pulmonary Fibrosis
Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and its Pharmacokinetic Application.
Idiopathic Pulmonary Fibrosis
DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis.
Idiopathic Pulmonary Fibrosis
Protein kinase D is increased and activated in lung epithelial cells and macrophages in idiopathic pulmonary fibrosis.
Ileitis
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
Immune System Diseases
Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2016-2019).
Immune System Diseases
Inhibition of GSK-3? Alleviates Collagen II-Induced Rheumatoid Arthritis in Rats.
Immune System Diseases
Inter-chromosomal variation in the pattern of human population genetic structure.
Immune System Diseases
LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.
Infarction, Middle Cerebral Artery
14-3-3 Isoforms Differentially Regulate NF?B Signaling in the Brain After Ischemia-Reperfusion.
Infarction, Middle Cerebral Artery
AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.
Infarction, Middle Cerebral Artery
Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats.
Infarction, Middle Cerebral Artery
Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection.
Infarction, Middle Cerebral Artery
c-Jun N-terminal kinase (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusion.
Infarction, Middle Cerebral Artery
Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO.
Infarction, Middle Cerebral Artery
Different expression of glycogen synthase kinase-3beta between young and old rat brains after transient middle cerebral artery occlusion.
Infarction, Middle Cerebral Artery
Immunoreactive Akt, PI3-K and ERK protein kinase expression in ischemic rat brain.
Infarction, Middle Cerebral Artery
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase II? Suppresses Oxidative Stress in Cerebral Ischemic Rats Through Targeting Glucose 6-Phosphate Dehydrogenase.
Infarction, Middle Cerebral Artery
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Infarction, Middle Cerebral Artery
MiR-124 affects the apoptosis of brain vascular endothelial cells and ROS production through regulating PI3K/AKT signaling pathway.
Infarction, Middle Cerebral Artery
Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain.
Infarction, Middle Cerebral Artery
Pien-Tze-Huang protects cerebral ischemic injury by inhibiting neuronal apoptosis in acute ischemic stroke rats.
Infarction, Middle Cerebral Artery
Polyamine analogue QMA attenuated ischemic injury in MCAO rats via ERK and Akt activated Nrf2/HO-1 signaling pathway.
Infarction, Middle Cerebral Artery
SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury.
Infarction, Middle Cerebral Artery
Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke.
Infarction, Middle Cerebral Artery
The CD40/CD40L system regulates rat cerebral microvasculature after focal ischemia/reperfusion via the mTOR/S6K signaling pathway.
Infarction, Middle Cerebral Artery
The effect of cyclosporin a on ischemia-reperfusion damage in a mouse model of ischemic stroke.
Infarction, Middle Cerebral Artery
The JNK inhibitor XG-102 protects from ischemic damage with delayed intravenous administration also in the presence of recombinant tissue plasminogen activator.
Infarction, Middle Cerebral Artery
Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo.
Infections
14-3-3 and enolase abundances in the CSF of Prion diseased rats.
Infections
14-3-3 and erlin proteins differentially interact with RIPK2 complexes.
Infections
14-3-3 Protein in CSF Reflects SIV-Mediated Pre-Synaptic Damage.
Infections
14-3-3 protein in CSF: an early predictor of SIV CNS disease.
Infections
14-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoform.
Infections
14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr.
Infections
14-3-3?/?-A interacts with glycoprotein of spring viremia of carp virus and positively affects viral entry.
Infections
14-3-3{epsilon} and 14-3-3? inhibit TLR-mediated pro-inflammatory cytokine induction.
Infections
A defect in nir1, a nirA-like transcription factor, confers morphological abnormalities and loss of pathogenicity in Colletotrichum acutatum.
Infections
A Eukaryotic-like Serine/Threonine Kinase Protects Staphylococci against Phages.
Infections
A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis.
Infections
A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response.
Infections
A loss-of-function screen reveals Ras- and Raf-independent MEK-ERK signaling during Chlamydia trachomatis infection.
Infections
A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons.
Infections
A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic mice.
Infections
A plant kinase plays roles in defense response against geminivirus by phosphorylation of a viral pathogenesis protein.
Infections
A Plasmodium berghei putative serine-threonine kinase 2 (PBANKA_0311400) is required for late liver stage development and timely initiation of blood stage infection.
Infections
A practical approach to avoiding iatrogenic Creutzfeldt-Jakob disease (CJD) from invasive instruments.
Infections
A protein kinase A-dependent mechanism by which rotavirus affects the distribution and mRNA level of the functional tight junction-associated protein, occludin, in human differentiated intestinal Caco-2 cells.
Infections
A Raf kinase inhibitor demonstrates antiviral activities both in vitro and in vivo against different genotypes of virulent Newcastle disease virus.
Infections
A role for the tfs3 ICE-encoded type IV secretion system in pro-inflammatory signalling by the Helicobacter pylori Ser/Thr kinase, CtkA.
Infections
Absence of mitogen-activated protein kinase family member c-Jun N-terminal kinase-2 enhances resistance to Toxoplasma gondii.
Infections
Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling.
Infections
Activation of a ribosomal protein S6 kinase in mouse fibroblasts during infection with herpesvirus.
Infections
Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1.
Infections
Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis.
Infections
Active c-jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3beta is required for tau aggregation.
Infections
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
Infections
Allogeneic Stem Cell Transplantation after Fanconi Anemia Conditioning in Children with Ataxia-Telangiectasia Results in Stable T Cell Engraftment and Lack of Infections despite Mixed Chimerism.
Infections
An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice.
Infections
An Artificial Neural Network-Based Pediatric Mortality Risk Score: Development and Performance Evaluation Using Data From a Large North American Registry.
Infections
An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.
Infections
Analysis of correlation between HP infection and activation of PI3K/Akt pathway in mucosal tissues of gastric cancer and precancerous lesions.
Infections
Analysis of the potato calcium-dependent protein kinase family and characterization of StCDPK7, a member induced upon infection with Phytophthora infestans.
Infections
Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection.
Infections
Anti-malarial and cytokine-modulating effects of andrographolide in a murine model of malarial infection.
Infections
Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cells.
Infections
Antisense Oligonucleotides Targeting Raf-1 Block Japanese Encephalitis Virus In Vitro and In Vivo.
Infections
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses.
Infections
ASC-deficiency impairs host defense against Aeromonas hydrophila infection in Japanese medaka, Oryzias latipes.
Infections
Association of mitogen-activated protein kinase pathways with gingival epithelial cell responses to Porphyromonas gingivalis infection.
Infections
Ataxia telangiectasia mutated kinase controls chronic gammaherpesvirus infection.
Infections
Ataxia Telangiectasia Mutated Kinase Mediates NF-?B Serine 276 Phosphorylation and Interferon Expression via the IRF7-RIG-I Amplification Loop in Paramyxovirus Infection.
Infections
ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection.
Infections
ATM kinase is activated by sindbis viral vector infection.
Infections
B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection.
Infections
Bacteriophage T7 protein kinase: Site of inhibitory autophosphorylation, and use of dephosphorylated enzyme for efficient modification of protein in vitro.
Infections
Baculovirus-mediated gene transfer and recombinant protein expression do not interfere with insulin dependent phosphorylation of PKB/Akt in human SHSY-5Y and C3A cells.
Infections
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.
Infections
Bioinformatic analysis reveals new determinants of antigenic 14-3-3 proteins and a novel antifungal strategy.
Infections
Bovine herpesvirus 1 can efficiently infect the human (SH-SY5Y) but not the mouse neuroblastoma cell line (Neuro-2A).
Infections
Broad-Spectrum Inhibition of Respiratory Virus Infection by MicroRNA Mimics Targeting p38 MAPK Signaling.
Infections
c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production.
Infections
c-Jun N-terminal Kinase is a critical node in the death of CD4,(+) CD8(+) thymocytes during Salmonella enterica serovar Typhimurium infection.
Infections
c-Jun N-terminal kinase negatively regulates dsRNA and RSV induction of tumor necrosis factor- alpha transcription in human epithelial cells.
Infections
Ca(2+) /calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation in Helicobacter pylori infection.
Infections
Ca2+ -dependent release of ATP from astrocytes affects herpes simplex virus type 1 infection of neurons.
Infections
CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy.
Infections
cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis.
Infections
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle.
Infections
Catechins containing a galloyl moiety as potential anti-HIV-1 compounds.
Infections
Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection.
Infections
Cellular Protein Kinase D Modulators Play a Role during Multiple Steps of Herpes Simplex Virus Type 1 Egress.
Infections
Cellular signals involved in cyclooxygenase-2 expression induced by human cytomegalovirus.
Infections
Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.
Infections
Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02.
Infections
Chronic nonsteroidal anti-inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa.
Infections
clk1, a serine/threonine protein kinase-encoding gene, is involved in pathogenicity of Colletotrichum lindemuthianum on common bean.
Infections
Co-administration of interleukins 7 and 15 with DNA vaccine improves protective immunity against Toxoplasma gondii.
Infections
Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing.
Infections
Computational assessment of saikosaponins as adjuvant treatment for COVID-19: molecular docking, dynamics, and network pharmacology analysis.
Infections
Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes.
Infections
Correction: Paracoccidoides brasiliensis 30 kDa Adhesin: Identification as a 14-3-3 Protein, Cloning and Subcellular Localization in Infection Models.
Infections
Cross-talk between STAT1 and PI3K/AKT signaling in HIV-1-induced blood-brain barrier dysfunction: Role of CCR5 and implications for viral neuropathogenesis.
Infections
Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III.
Infections
Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.
Infections
Dexamethasone Downregulates Expressions of 14-3-3? and ?-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection.
Infections
Dietary iron deficiency impaired intestinal immune function of on-growing grass carp under the infection of Aeromonas hydrophila: Regulation of NF-?B and TOR signaling.
Infections
Dietary vitamin C deficiency depressed the gill physical barriers and immune barriers referring to Nrf2, apoptosis, MLCK, NF-?B and TOR signaling in grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare.
Infections
Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori.
Infections
Differential Effects of Human SP-A1 and SP-A2 on the BAL Proteome and Signaling Pathways in Response to Klebsiella pneumoniae and Ozone Exposure.
Infections
Differential roles of Yersinia outer protein P-mediated inhibition of nuclear factor-kappa B in the induction of cell death in dendritic cells and macrophages.
Infections
Differentiation of varicella-zoster virus ORF47 protein kinase and IE62 protein binding domains and their contributions to replication in human skin xenografts in the SCID-hu mouse.
Infections
DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells.
Infections
Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells.
Infections
DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1? Signaling.
Infections
Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease.
Infections
Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus.
Infections
EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency.
Infections
Ectopic expression of a novel Ser/Thr protein kinase from cotton (Gossypium barbadense), enhances resistance to Verticillium dahliae infection and oxidative stress in Arabidopsis.
Infections
Effects of silencing 14-3-3 protein in Paracoccidiodes brasiliensis infection.
Infections
Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection.
Infections
Effects of the PI3K/Akt signaling pathway on the apoptosis of early host cells infected with Eimeria tenella.
Infections
Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins.
Infections
Equine herpesvirus 1 enters cells by two different pathways, and infection requires the activation of the cellular kinase ROCK1.
Infections
ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells.
Infections
Excretory/secretory products from in vitro-cultured Echinococcus granulosus protoscoleces.
Infections
Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt.
Infections
Expression of P-Akt, NFkappaB and their correlation with human papillomavirus infection in cervical carcinoma.
Infections
Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection.
Infections
Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway.
Infections
Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection.
Infections
Foot-and-Mouth Disease Virus Structural Protein VP1 Destroys the Stability of TPL2 Trimer by Degradation TPL2 to Evade Host Antiviral Immunity.
Infections
FOXO regulates the expression of antimicrobial peptides and promotes phagocytosis of hemocytes in shrimp antibacterial immunity.
Infections
Functional Interaction between Apolipophorins and Complement Regulate the Mosquito Immune Response to Systemic Infections.
Infections
Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression.
Infections
Gene expression of Paracoccidioides virulence factors after interaction with macrophages and fibroblasts.
Infections
Genetic mapping and development of co-segregating markers of RpsQ, which provides resistance to Phytophthora sojae in soybean.
Infections
Gerbu adjuvant modulates the immune response and thus the course of infection in C56BL/6 mice immunised with Echinococcus multilocularis rec14-3-3 protein.
Infections
Glia maturation factor overexpression in neuroblastoma cells activates glycogen synthase kinase-3beta and caspase-3.
Infections
Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism.
Infections
Glycogen Synthase Kinase-3 Modulates Neurite Outgrowth in Cultured Neurons: Possible Implications for Neurite Pathology in Alzheimer's Disease.
Infections
Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice.
Infections
Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins.
Infections
Glycogen synthetase kinase 3 inhibition drives MIC-A/B to promote cytokine production by human natural killer cells in Dengue virus type 2 infection.
Infections
GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response.
Infections
GSK3?: A plausible molecular target in the cytokinemodulating effect of exogenous insulin in a murine model of malarial infection.
Infections
Guava flavonoid glycosides prevent influenza A virus infection via rescue of P53 activity.
Infections
Helicobacter pylori activate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3beta phosphorylation.
Infections
Helicobacter pylori in a Korean Isolate Expressed Proteins Differentially in Human Gastric Epithelial Cells.
Infections
Helicobacter pylori induces cell migration and invasion through casein kinase 2 in gastric epithelial cells.
Infections
Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo(-/-) mice.
Infections
Helicobacter pylori infection of gastric cancer cells elevates the level of expression and activation of protein kinase d2.
Infections
Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1).
Infections
Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.
Infections
Helicobacter pylori-induced cell death is counteracted by NF-?B-mediated transcription of DARPP-32.
Infections
Hepatitis B virus e antigen physically associates with receptor-interacting serine/threonine protein kinase 2 and regulates IL-6 gene expression.
Infections
Hepatitis C virus infection downregulates the ligands of the activating receptor NKG2D.
Infections
Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway.
Infections
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
Infections
Hepatitis C Virus Regulates Transforming Growth Factor beta1 Production Through the Generation of Reactive Oxygen Species in a Nuclear Factor kappaB-Dependent Manner.
Infections
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.
Infections
Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-? protein accumulation.
Infections
Herpes simplex virus-1 specifically targets human CD1d antigen presentation to enhance its pathogenicity.
Infections
HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
Infections
HIPK2 is necessary for type I interferon-mediated antiviral immunity.
Infections
HIV-1 Nef-Induced Secretion of the Proinflammatory Protease TACE into Extracellular Vesicles Is Mediated by Raf-1 and Can Be Suppressed by Clinical Protein Kinase Inhibitors.
Infections
Host DNA damage response facilitates African swine fever virus infection.
Infections
Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerization.
Infections
HSV-1 Hijacks the Host DNA Damage Response in Corneal Epithelial Cells through ICP4-Mediated Activation of ATM.
Infections
HSV-I and the cellular DNA damage response.
Infections
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection.
Infections
Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response.
Infections
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins.
Infections
Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death.
Infections
Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis.
Infections
Human herpesvirus 6B induces cell cycle arrest concomitant with p53 phosphorylation and accumulation in T cells.
Infections
Human immunodeficiency virus type 1 (HIV-1) infection and expression in intestinal epithelial cells: role of protein kinase A and C pathways in HIV-1 transcription.
Infections
Human Immunodeficiency Virus Type 1 Induces Lytic Cycle Replication of Kaposi's-Sarcoma-Associated Herpesvirus: Role of Ras/c-Raf/MEK1/2, PI3K/AKT, and NF-?B Signaling Pathways.
Infections
Human immunodeficiency virus type 1 replication in dendritic cell-T-cell cocultures is increased upon incorporation of host LFA-1 due to higher levels of virus production in immature dendritic cells.
Infections
Identification and characterization of the role of c-terminal Src kinase in dengue virus replication.
Infections
Identification and expression analysis of two splice variants of the 14-3-3 epsilon from Litopenaeus Vannamei during WSSV infections.
Infections
Identification of novel human kinases that suppress hepatitis C virus infection.
Infections
Identification of the differential expression of genes and upstream microRNAs in small cell lung cancer compared with normal lung based on bioinformatics analysis.
Infections
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
Infections
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain.
Infections
Impaired hyperphosphorylation of rotavirus NSP5 in cells depleted of casein kinase 1alpha is associated with the formation of viroplasms with altered morphology and a moderate decrease in virus replication.
Infections
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.
Infections
Increased 14-3-3? and ? protein isoform expressions in parasitic eosinophilic meningitis caused by Angiostrongylus cantonensis infection in mice.
Infections
Increased number of CpG island hypermethylation in tumor suppressor genes of non-neoplastic gastric mucosa correlates with higher risk of gastric cancer.
Infections
Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer.
Infections
Induction of Central Host Signaling Kinases during Pneumococcal Infection of Human THP-1 Cells.
Infections
Induction of DNA Damage Signaling upon Rift Valley Fever Virus Infection Results in Cell Cycle Arrest and Increased Viral Replication.
Infections
Induction of host gene expression following infection of chicken embryo fibroblasts with oncogenic Marek's disease virus.
Infections
Inductive expression of the NOD1 signalling pathway in chickens infected with Salmonella pullorum.
Infections
Infection of a Single Cell Line with Distinct Strains of Human Cytomegalovirus Can Result in Large Variations in Virion Production and Facilitate Efficient Screening of Virus Protein Function.
Infections
Infection of Prions and Treatment of PrP106-126 Alter the Endogenous Status of Protein 14-3-3 and Trigger the Mitochondrial Apoptosis Possibly via Activating Bax Pathway.
Infections
Inflammation kinase PKR phosphorylates ?-synuclein and causes ?-synuclein-dependent cell death.
Infections
Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome.
Infections
Influenza Induces ER Stress, Caspase-12- Dependent Apoptosis and JNK Mediated TGF-{beta} Release in Lung Epithelial Cells.
Infections
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Infections
Inhibition of Akt/GSK3beta signalling pathway by Legionella pneumophila is involved in induction of T-cell apoptosis.
Infections
Inhibition of glycogen synthase kinase 3beta suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of beta-catenin.
Infections
Inhibition of Glycogen Synthase Kinase-3{beta} Is Sufficient for Airway Smooth Muscle Hypertrophy.
Infections
Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells.
Infections
Interferon gamma induces cellular protein alteration and increases replication of porcine circovirus type 2 in PK-15 cells.
Infections
Interferon-? signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells.
Infections
Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis.
Infections
Invasion of HeLa cells by group B streptococcus requires the phosphoinositide-3-kinase signalling pathway and modulates phosphorylation of host-cell Akt and glycogen synthase kinase-3.
Infections
Involvement of the mitogen-activated protein kinase pathway in soft-shelled turtle iridovirus-induced apoptosis.
Infections
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Infections
iTRAQ protein profile analysis provides integrated insight into mechanisms of tolerance to TMV in tobacco (Nicotiana tabacum).
Infections
Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response.
Infections
JNK1 Derived from Orange-Spotted Grouper, Epinephelus coioides, Involving in the Evasion and Infection of Singapore Grouper Iridovirus (SGIV).
Infections
Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and autophagy.
Infections
Kinome analysis of host response to mycobacterial infection: a novel technique in proteomics.
Infections
Laodelphax striatellus Atg8 facilitates Rice stripe virus infection in an autophagy-independent manner.
Infections
Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophages.
Infections
Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: role of protein kinase Czeta and phosphatase.
Infections
Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome.
Infections
Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis.
Infections
Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors.
Infections
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.
Infections
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
Infections
LRRK2 in Infection: Friend or Foe?
Infections
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
Infections
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.
Infections
LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.
Infections
Lymphomagenesis-related gene expression in B cells from sustained virological responders with occult hepatitis C virus infection.
Infections
Lysophosphatidylcholine Promotes Phagosome Maturation and Regulates Inflammatory Mediator Production Through the Protein Kinase A-Phosphatidylinositol 3?Kinase-p38 Mitogen-Activated Protein Kinase Signaling Pathway During Mycobacterium tuberculosis Infection in Mouse Macrophages.
Infections
M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival.
Infections
Macrophage Polarization Modulated by Porcine Circovirus Type 2 Facilitates Bacterial Coinfection.
Infections
Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35.
Infections
Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2.
Infections
MAPK activation is involved in posttranscriptional regulation of RSV-induced RANTES gene expression.
Infections
Meeting of conventional and unconventional pathways at the TGN.
Infections
Mitogen-activated protein kinases regulate Mycobacterium avium-induced tumor necrosis factor-alpha release from macrophages.
Infections
Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection.
Infections
Molecular features of interleukin-1 receptor-associated kinase-b and a in Mytilus coruscus, regulating their function by infection of aquatic pathogens and the expression of their serine/threonine protein kinase functional domains.
Infections
mTOR-independent autophagy counteracts apoptosis in herpes simplex virus type 1-infected U251 glioma cells.
Infections
Multifaceted Role of AMPK in Viral Infections.
Infections
Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication.
Infections
Mycobacterium bovis bacillus Calmette-Guerin induces CCL5 secretion via the Toll-like receptor 2-NF-kappaB and -Jun N-terminal kinase signaling pathways.
Infections
Mycobacterium massiliense induces inflammatory responses in macrophages through Toll-like receptor 2 and c-Jun N-terminal kinase.
Infections
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity.
Infections
N-terminal interaction domain implicates PAK4 in translational regulation and reveals novel cellular localization signals.
Infections
New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth.
Infections
NKG2D Signaling: The Immune Subversive Side of HDAC3.
Infections
NMDA receptor subunit and CaMKII changes in rat hippocampus by congenital HCMV infection: a mechanism for learning and memory impairment.
Infections
NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-?B, and also MDA5, RIG-I and MAVS.
Infections
Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase.
Infections
Optimizing Small Molecule Inhibitors of Calcium-Dependent Protein Kinase 1 to Prevent Infection by Toxoplasma gondii.
Infections
OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism.
Infections
ORF9p phosphorylation by ORF47p is crucial for the formation and egress of varicella-zoster virus viral particles.
Infections
P27Kip1, regulated by glycogen synthase kinase-3beta, results in HMBA-induced differentiation of human gastric cancer cells.
Infections
p38(MAPK)/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection.
Infections
Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model.
Infections
Paracoccidoides brasiliensis 30 kDa adhesin: identification as a 14-3-3 protein, cloning and subcellular localization in infection models.
Infections
Parkinson's disease-associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages.
Infections
Parvovirus B19 Infection of Human Primary Erythroid Progenitor Cells Triggers ATR-Chk1 Signaling, Which Promotes B19 Virus Replication.
Infections
Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells.
Infections
Pathogen-regulated genes in wheat isogenic lines differing in resistance to brown rust Puccinia triticina.
Infections
PDPK1 regulates autophagosome biogenesis by binding to PIK3C3.
Infections
Peroxiredoxin 1 Interacts with TBK1/IKK? and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.
Infections
Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.
Infections
Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells.
Infections
Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.
Infections
Phosphoproteomic analysis reveals the importance of kinase regulation during orbivirus infection.
Infections
Phosphorylated AKT expression in tumor-adjacent normal tissue is associated with poor prognosis in patients with hepatocellular carcinoma.
Infections
Phosphorylated baculovirus p10 is a heat-stable microtubule-associated protein associated with process formation in Sf9 cells.
Infections
Phosphorylation of chromosomal proteins during the transition of a normal plant cell to a crown gall tumor cell.
Infections
Phosphorylation of elongation factor G and ribosomal protein S6 in bacteriophage T7-infected Escherichia coli.
Infections
Phosphorylation of the herpes simplex virus type 1 tegument protein VP22.
Infections
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Infections
PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction.
Infections
PKA-dependent dynein switching from lysosomes to adenovirus: a novel form of host-virus competition.
Infections
PKA/KIN-1 mediates innate immune responses to bacterial pathogens in Caenorhabditis elegans.
Infections
Plus-end tracking proteins, CLASPs, and a viral Akt mimic regulate herpesvirus-induced stable microtubule formation and virus spread.
Infections
Protective effects of SP600125 on mice infected with H1N1 influenza A virus.
Infections
Protective Immunity Against Neospora caninum Infection Induced by 14-3-3 Protein in Mice.
Infections
Protective role for interferon-beta in coxsackievirus B3 infection.
Infections
Protective role of Raf-1 in Salmonella-induced macrophage apoptosis.
Infections
Protein Kinase A phosphorylation activates Vpr-induced cell cycle arrest during Human Immunodeficiency Virus Type-1 infection.
Infections
Protein kinase A-mediated inhibition of gamma interferon-induced tyrosine phosphorylation of Janus kinases and latent cytoplasmic transcription factors in human monocytes by Ehrlichia chaffeensis.
Infections
Protein Kinase B/Akt Is Present in Activated Form throughout the Entire Replicative Cycle of {Delta}US3 Mutant Virus but Only at Early Times after Infection with Wild-Type Herpes Simplex Virus 1.
Infections
Protein kinase D-dependent trafficking of the large Herpes simplex virus type 1 capsids from the TGN to plasma membrane.
Infections
Protein kinase of bacteriophage T7. 1. Purification.
Infections
Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma.
Infections
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
Infections
Proteomic analysis of differentially expressed proteins in Penaeus monodon hemocytes after Vibrio harveyi infection.
Infections
Proteomic profiles of mouse neuro N2a cells infected with variant virulence of rabies viruses.
Infections
Purification and characterization of the protein kinase encoded by the UL13 gene of herpes simplex virus type 2.
Infections
Rabies virus-induced activation of mitogen-activated protein kinase and NF-kappaB signaling pathways regulates expression of CXC and CC chemokine ligands in microglia.
Infections
Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis.
Infections
Ras effector pathway activation by epidermal growth factor is inhibited in vivo by exoenzyme S ADP-ribosylation of Ras.
Infections
Receptor-Interacting Protein Kinase-2 Inhibition by CYLD Impairs Antibacterial Immune Responses in Macrophages.
Infections
Redox Status, JA and ET Signaling Pathway Regulating Responses to Botrytis cinerea Infection Between the Resistant Cucumber Genotype and Its Susceptible Mutant.
Infections
Reduced Parasite Motility and Micronemal Protein Secretion by a p38 MAPK Inhibitor Leads to a Severe Impairment of Cell Invasion by the Apicomplexan Parasite Eimeria tenella.
Infections
Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells.
Infections
Regulation of gene expression in lymphocytes and antigen-presenting cells by measles virus: consequences for immunomodulation.
Infections
Regulation of protein kinase CKII by direct interaction with the C-terminal region of p47(phox).
Infections
Regulation of taurine transport by Escherichia coli heat-stable enterotoxin and guanylin in human intestinal cell lines.
Infections
Regulation of TBK1 activity by Optineurin contributes to cell cycle-dependent expression of the interferon pathway.
Infections
Regulation of viral intermediate gene expression by the vaccinia virus B1 protein kinase.
Infections
Regulatory Role of GSK-3 ? on NF- ? B, Nitric Oxide, and TNF- ? in Group A Streptococcal Infection.
Infections
Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease.
Infections
Requirement of p21-activated kinase (PAK) for Salmonella typhimurium-induced nuclear responses.
Infections
Resistance of ribosomal protein mRNA translation to protein synthesis shutoff induced by poliovirus.
Infections
Respiratory syncytial virus induces insensitivity to beta-adrenergic agonists in mouse lung epithelium in vivo.
Infections
Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway.
Infections
Revisiting Ehrlichia ruminantium Replication Cycle Using Proteomics: The Host and the Bacterium Perspectives.
Infections
Rhabdovirus Infection Is Dependent on Serine/Threonine Kinase AP2-Associated Kinase 1.
Infections
Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor ?B and c-Jun N-terminal kinase activation.
Infections
Rho-Associated Coiled-Coil Kinase 1 Translocates to the Nucleus and Inhibits Human Cytomegalovirus Propagation.
Infections
RhoA/ROCK1 regulates Avian Reovirus S1133-induced switch from autophagy to apoptosis.
Infections
RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases.
Infections
RIPK3 Facilitates Host Resistance to Oral Toxoplasma gondii Infection.
Infections
Role of Glycogen Synthase Kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus.
Infections
Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer.
Infections
Role of the JNK Pathway in Varicella-Zoster Virus Lytic Infection and Reactivation.
Infections
Role of the serine-threonine kinase PAK-1 in myxoma virus replication.
Infections
Roles of ATM and ATR-Mediated DNA Damage Responses during Lytic BK Polyomavirus Infection.
Infections
Roles of Stress-Activated Protein Kinases in the replication of Singapore grouper iridovirus and regulation of the inflammatory responses in grouper cells.
Infections
Rotavirus activates a noncanonical ATM-Chk2 branch of DNA damage response during infection to positively regulate viroplasm dynamics.
Infections
Screening of PI3K-Akt-targeting Drugs for Silkworm against Bombyx mori Nucleopolyhedrovirus.
Infections
Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.
Infections
Signal transduction pathways and apoptosis in bacteria infected chondrocytes.
Infections
Simian virus 40 infection triggers a balanced network that includes apoptotic, survival, and stress pathways.
Infections
SnRK1 phosphorylation of AL2 delays Cabbage leaf curl virus infection in Arabidopsis.
Infections
SnRK1: a versatile plant protein kinase that limits geminivirus infection.
Infections
Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.
Infections
Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response.
Infections
Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution.
Infections
Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens.
Infections
Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection.
Infections
Suppression of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor.
Infections
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia.
Infections
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection.
Infections
Testosterone attenuates p38 MAPK pathway during Leishmania donovani infection of macrophages.
Infections
The 14-3-3 protein as a vaccine candidate against schistosomiasis.
Infections
The 14-3-3 protein is secreted by the adult worm of Echinococcus granulosus.
Infections
The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication.
Infections
The Autophagy-Initiating Protein Kinase ULK1 Phosphorylates Human Cytomegalovirus Tegument Protein pp28 and Regulates Efficient Virus Release.
Infections
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.
Infections
The Echinococcus multilocularis 14-3-3 protein protects mice against primary but not secondary alveolar echinococcosis.
Infections
The effect of human immunodeficiency virus-1 on monocyte-derived dendritic cell maturation and function.
Infections
The future of RIP2/RICK/CARDIAK as a biomarker of the inflammatory response to infection.
Infections
The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins.
Infections
The Mechanism of SARS-CoV-2 Nucleocapsid Protein Recognition by the Human 14-3-3 Proteins.
Infections
The Multifarious Role of 14-3-3 Family of Proteins in Viral Replication.
Infections
The persistent effects of maternal infection on the offspring's cognitive performance and rates of hippocampal neurogenesis.
Infections
The Protein Dredd Is an Essential Component of the c-Jun N-terminal Kinase Pathway in the Drosophila Immune Response.
Infections
The regenerating family member 3 ? instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.
Infections
The Sb14-3-3zeta recombinant protein protects against Schistosoma bovis in BALB/c mice.
Infections
The Schistosoma bovis Sb14-3-3zeta recombinant protein cross-protects against Schistosoma mansoni in BALB/c mice.
Infections
The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection.
Infections
Time-course studies of 14-3-3 protein isoforms in cerebrospinal fluid and brain of primates after oral or intracerebral infection with bovine spongiform encephalopathy agent.
Infections
Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice.
Infections
Toxoplasma gondii: effect of infection on expression of 14-3-3 proteins in human epithelial cells.
Infections
Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination.
Infections
TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation.
Infections
Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages.
Infections
Transcriptional activation of a maize calcium-dependent protein kinase gene in response to fungal elicitors and infection.
Infections
Transcriptional response of bean bug (Riptortus pedestris) upon infection with entomopathogenic fungus, Beauveria bassiana JEF-007.
Infections
Transient overexpression of alpha-Ca2+/calmodulin-dependent protein kinase II in the nucleus accumbens shell enhances behavioral responding to amphetamine.
Infections
Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells.
Infections
Type I Interferons, Autophagy and Host Metabolism in Leprosy.
Infections
Upregulation of 14-3-3 eta in chronic liver fluke infection is a potential diagnostic marker of cholangiocarcinoma.
Infections
Viral oncolysis that targets Raf-1 signaling control of nuclear transport.
Infections
XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures.
Infections
Yersinia enterocolitica Exploits Signal Crosstalk between Complement 5a Receptor and Toll-like Receptor 1/2 and 4 to Avoid the Bacterial Clearance in M cells.
Infections
YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathway.
Infections
[Correlation of HIPK2 expression with HPV infection and apoptosis in cervical cancer]
Infections
[Lentiviral vectors carrying siRNA inhibit S1PR3 gene expression in the corpus cavernosum smooth muscle cells of rats with spontaneous hypertension].
Infertility
A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans.
Infertility
AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice.
Infertility
Construction and analysis of a human testis/sperm-enriched interaction network: Unraveling the PPP1CC2 interactome.
Infertility
Effects of Radiofrequency Electromagnetic Wave Exposure from Cellular Phones on the Reproductive Pattern in Male Wistar Rats.
Infertility
FRET-based sensor for CaMKII activity (FRESCA): A useful tool for assessing CaMKII activity in response to Ca2+ oscillations in live cells.
Infertility
Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases.
Infertility
Some Single Nucleotide Polymorphisms of the TSSK2 Gene May Be Associated with Human Spermatogenesis Impairment.
Infertility
Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency.
Infertility
The octopamine receptor Oct?2R regulates ovulation in Drosophila melanogaster.
Infertility
TSKS concentrates in spermatid centrioles during flagellogenesis.
Infertility
[Effects of phosphatidylinositol-3 kinase/protein kinase b/bone morphogenetic protein-15 pathway on the follicular development in the mammalian ovary].
Infertility, Female
Dysregulation of the anti-Müllerian hormone system by steroids in women with polycystic ovary syndrome.
Infertility, Female
Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice.
Infertility, Male
Expression of antisense SnRK1 protein kinase sequence causes abnormal pollen development and male sterility in transgenic barley.
Infertility, Male
Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.
Infertility, Male
Mapping of cis-regulatory sites in the promoter of testis-specific stellate genes of Drosophila melanogaster.
Infertility, Male
Mutation screening and association study of the TSSK4 Gene in Chinese infertile men with impaired spermatogenesis.
Infertility, Male
Overexpression of the lily p70(s6k) gene in Arabidopsis affects elongation of flower organs and indicates TOR-dependent regulation of AP3, PI and SUP translation.
Infertility, Male
Oxidative stress and sperm function: A systematic review on evaluation and management.
Infertility, Male
Rapid Detection of Glycogen Synthase Kinase-3 Activity in Mouse Sperm Using Fluorescent Gel Shift Electrophoresis.
Infertility, Male
RNAi-Mediated Knockdown of Tssk1 and Tektin1 Genes Impair Male Fertility in Bactrocera dorsalis.
Infertility, Male
Searching for candidate genes for male infertility.
Infertility, Male
Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency.
Infertility, Male
Transcriptomic Analysis Reveals Insights on Male Infertility in Octopus maya Under Chronic Thermal Stress.
Inflammatory Bowel Diseases
6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) from Wasabia japonica alleviates inflammatory bowel disease (IBD) by potential inhibition of glycogen synthase kinase 3 beta (GSK-3?).
Inflammatory Bowel Diseases
ATG16L1 negatively regulates RICK/RIP2-mediated innate immune responses.
Inflammatory Bowel Diseases
CARD3 Deficiency Protects Against Colitis Through Reduced Epithelial Cell Apoptosis.
Inflammatory Bowel Diseases
Commensal bacteria direct selective cargo sorting to promote symbiosis.
Inflammatory Bowel Diseases
Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review).
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
Inflammatory Bowel Diseases
How autophagy controls the intestinal epithelial barrier.
Inflammatory Bowel Diseases
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
Inflammatory Bowel Diseases
Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2.
Inflammatory Bowel Diseases
Is LRRK2 the missing link between inflammatory bowel disease and Parkinson's disease?
Inflammatory Bowel Diseases
Leucine Rich Repeat Kinase 2 and Innate Immunity.
Inflammatory Bowel Diseases
LRRK2 and the Immune System.
Inflammatory Bowel Diseases
LRRK2 as a negative regulator of NFAT: implications for the pathogenesis of inflammatory bowel disease.
Inflammatory Bowel Diseases
Metformin protects against intestinal barrier dysfunction via AMPK?1-dependent inhibition of JNK signalling activation.
Inflammatory Bowel Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Inflammatory Bowel Diseases
Novel Thienopyridines as RIPK2 Inhibitors for Treating Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Inflammatory Bowel Diseases
RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases.
Inflammatory Bowel Diseases
RIPK2 NODs to XIAP and IBD.
Inflammatory Bowel Diseases
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Inflammatory Bowel Diseases
The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
The role of LRRK2 in inflammatory bowel disease.
Inflammatory Bowel Diseases
The roles of microbial products in the development of colorectal cancer: a review.
Inflammatory Breast Neoplasms
Erratum: Zare, A. et al. RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis. Cancers, 2018, 10, 184.
Inflammatory Breast Neoplasms
Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer.
Inflammatory Breast Neoplasms
RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis.
Influenza, Human
14-3-3 protein detection in the cerebrospinal fluid of patients with influenza-associated encephalopathy.
Influenza, Human
Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1.
Influenza, Human
Activators of protein kinase A stimulate apical but not basolateral transport in epithelial Madin-Darby canine kidney cells.
Influenza, Human
Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.
Influenza, Human
Broad-Spectrum Inhibition of Respiratory Virus Infection by MicroRNA Mimics Targeting p38 MAPK Signaling.
Influenza, Human
Casein Kinase 1? Mediates the Degradation of Receptors for Type I and Type II Interferons Caused by Hemagglutinin of Influenza A Virus.
Influenza, Human
Characterisation of the influenza virus associated protein kinase and its resemblance to casein kinase II.
Influenza, Human
Continuous Blood purification on Influenza-Associated Neurological Disease in children: a retrospective cohort study.
Influenza, Human
Differential activation of the c-Jun N-terminal kinase/stress-activated protein kinase and p38 mitogen-activated protein kinase signal transduction pathways in the mouse brain upon infection with neurovirulent influenza A virus.
Influenza, Human
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Influenza, Human
Human host factors required for influenza virus replication.
Influenza, Human
Identification of a casein kinase II phosphorylation domain in NS1 protein of H5N1 influenza virus.
Influenza, Human
Influenza A virus induces Interleukin-27 through cyclooxygenase-2 and protein kinase A signaling.
Influenza, Human
Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked.
Influenza, Human
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Influenza, Human
Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis.
Influenza, Human
Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection.
Influenza, Human
Inhibition of c-Jun N-terminal kinase rescues influenza epitope-specific human cytolytic T lymphocytes from activation-induced cell death.
Influenza, Human
Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis.
Influenza, Human
Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice.
Influenza, Human
Mitogen-activated protein kinase-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection.
Influenza, Human
Mycobacterial immunomodulation and viral manipulation of neuronal copper efflux in the setting of sporadic Parkinson's disease: A multi - hit, outside - in hypothesis of its pathogenesis.
Influenza, Human
p38MAPK, Rho/ROCK and PKC pathways are involved in influenza-induced cytoskeletal rearrangement and hyperpermeability in PMVEC via phosphorylating ERM.
Influenza, Human
Role of G protein and protein kinase signalling in influenza virus budding in MDCK cells.
Influenza, Human
Role of the p21-activated kinases (PAKs) in influenza A virus replication.
Influenza, Human
Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses.
Influenza, Human
Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.
Influenza, Human
Structure and Activities of the NS1 Influenza Protein and Progress in the Development of Small-Molecule Drugs.
Influenza, Human
Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers.
Influenza, Human
The c-Jun N-terminal kinase (JNK) is involved in H5N1 influenza A virus RNA and protein synthesis.
Influenza, Human
Viral strategies for triggering and manipulating mitophagy.
Insulin Resistance
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
Insulin Resistance
17?-estradiol ameliorates lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance.
Insulin Resistance
A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression.
Insulin Resistance
A high sucrose and high fat diet induced the development of insulin resistance in the skeletal muscle of Bama miniature pigs through the Akt/GLUT4 pathway.
Insulin Resistance
A low-protein, high-carbohydrate diet increases de novo fatty acid synthesis from glycerol and glycerokinase content in the liver of growing rats.
Insulin Resistance
A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury.
Insulin Resistance
A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle.
Insulin Resistance
A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response.
Insulin Resistance
A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans.
Insulin Resistance
A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus.
Insulin Resistance
A Single Nucleotide Polymorphism in STK11 Influences Insulin Sensitivity and Metformin Efficacy in Hyperinsulinemic Girls with Androgen Excess.
Insulin Resistance
A?-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and A? Secretion in Neural Cells.
Insulin Resistance
Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes.
Insulin Resistance
Abnormal regulation of ribosomal protein S6 kinase by insulin in skeletal muscle of insulin-resistant humans.
Insulin Resistance
Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response.
Insulin Resistance
Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin.
Insulin Resistance
Activation of skeletal muscle casein kinase II by insulin is not diminished in subjects with insulin resistance.
Insulin Resistance
Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle.
Insulin Resistance
Adipocytes from women with polycystic ovary syndrome demonstrate altered phosphorylation and activity of glycogen synthase kinase 3.
Insulin Resistance
Adlay Bran Oil Suppresses Hepatic Gluconeogenesis and Attenuates Hyperlipidemia in Type 2 Diabetes Rats.
Insulin Resistance
Aging is associated with increased TRB3, ER stress, and hepatic glucose production in the liver of rats.
Insulin Resistance
Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet.
Insulin Resistance
Amelioration of Insulin Resistance by Scopoletin in High-Glucose-Induced, Insulin-Resistant HepG2 Cells.
Insulin Resistance
Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy.
Insulin Resistance
Ampelopsin Improves Insulin Resistance by Activating PPAR? and Subsequently Up-Regulating FGF21-AMPK Signaling Pathway.
Insulin Resistance
AMPK in the small intestine in normal and pathophysiological conditions.
Insulin Resistance
An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice.
Insulin Resistance
Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces.
Insulin Resistance
Antidiabetic effects of Tangnaikang on obese Zucker rats and the mechanism.
Insulin Resistance
Antisense inhibition of S6 kinase 1 produces improved glucose tolerance and is well tolerated for 4 weeks of treatment in rats.
Insulin Resistance
Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance.
Insulin Resistance
Application of microRNAs in diabetes mellitus.
Insulin Resistance
Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt.
Insulin Resistance
Astragalus polysaccharide improves insulin sensitivity in KKAy mice: regulation of PKB/GLUT4 signaling in skeletal muscle.
Insulin Resistance
Asymmetric dimethylarginine targets MAPK pathway to regulate insulin resistance in liver by activating inflammation factors.
Insulin Resistance
Atrial fibrillation and its arrhythmogenesis associated with insulin resistance.
Insulin Resistance
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Insulin Resistance
Based on network pharmacology to explore the molecular mechanisms of astragalus membranaceus for treating T2 diabetes mellitus.
Insulin Resistance
Berberine attenuates fructose-induced insulin resistance by stimulating the hepatic LKB1/AMPK/PGC1? pathway in mice.
Insulin Resistance
Berberine improves insulin resistance in cardiomyocytes via activation of 5'-adenosine monophosphate-activated protein kinase.
Insulin Resistance
Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease.
Insulin Resistance
Biochemical mechanisms of insulin resistance.
Insulin Resistance
Blockade of mineralocorticoid receptor ameliorates oral contraceptive-induced insulin resistance by suppressing elevated uric acid and glycogen synthase kinase-3 instead of circulating mineralocorticoid.
Insulin Resistance
Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats.
Insulin Resistance
c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists.
Insulin Resistance
Calorie restriction prevents the development of insulin resistance and impaired lipid metabolism in gestational diabetes offspring.
Insulin Resistance
Camk2n1 Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity.
Insulin Resistance
Carbenoxolone ameliorates insulin sensitivity in obese mice induced by high fat diet via regulating the I?B-?/NF-?B pathway and NLRP3 inflammasome.
Insulin Resistance
CARD3 deficiency exacerbates diet-induced obesity, hepatosteatosis, and insulin resistance in male mice.
Insulin Resistance
Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation.
Insulin Resistance
Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.
Insulin Resistance
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.
Insulin Resistance
Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment.
Insulin Resistance
Changes in Brain 14-3-3 Proteins in Response to Insulin Resistance Induced by a High Palatable Diet.
Insulin Resistance
Chlorogenic acid alleviates autophagy and insulin resistance by suppressing JNK pathway in a rat model of nonalcoholic fatty liver disease.
Insulin Resistance
Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues.
Insulin Resistance
Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in prediabetic obese Zucker rats.
Insulin Resistance
Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues.
Insulin Resistance
Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats.
Insulin Resistance
Conditional ablation of Gsk-3beta in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice.
Insulin Resistance
Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle.
Insulin Resistance
Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake.
Insulin Resistance
Crosstalk of Diabetic Conditions with Static Versus Dynamic Flow Environment-Impact on Aortic Valve Remodeling.
Insulin Resistance
CtBP2 ameliorates palmitate-induced insulin resistance in HepG2 cells through ROS mediated JNK pathway.
Insulin Resistance
Cudrania tricuspidata water extract improved obesity-induced hepatic insulin resistance in db/db mice by suppressing ER stress and inflammation.
Insulin Resistance
Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress.
Insulin Resistance
CYP2J3 Gene Delivery Up-regulated Adiponectin Expression via Reduced Endoplasmic Reticulum Stress in Adipocytes.
Insulin Resistance
Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.
Insulin Resistance
Decreased muscle-derived musclin by chronic resistance exercise is associated with improved insulin resistance in rats with type 2 diabetes.
Insulin Resistance
Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance.
Insulin Resistance
Deficiency in the short-chain acyl-CoA dehydrogenase protects mice against diet-induced obesity and insulin resistance.
Insulin Resistance
Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.
Insulin Resistance
Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.
Insulin Resistance
Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors.
Insulin Resistance
Dietary leucine improves whole-body insulin sensitivity independent of body fat in diet-induced obese Sprague-Dawley rats.
Insulin Resistance
Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance.
Insulin Resistance
Dissociation of inositol-requiring enzyme (IRE1?)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.
Insulin Resistance
Double-Stranded RNA-Activated Protein Kinase Is a Key Modulator of Insulin Sensitivity in Physiological Conditions and in Obesity in Mice.
Insulin Resistance
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: the role of GSK-3beta in the maintenance of steady-state levels of insulin receptor signaling molecules and Na(v)1.7 sodium channel in adrenal chromaffin cells.
Insulin Resistance
Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetes.
Insulin Resistance
Early effect of Roux-en-Y gastric bypass on insulin sensitivity and signaling.
Insulin Resistance
Effect of chromium citrate on the mechanism of glucose transport and insulin resistance in Buffalo rat liver cells.
Insulin Resistance
Effect of combination of chlorella intake and aerobic exercise training on glycemic control in type 2 diabetic rats.
Insulin Resistance
Effect of vanadate on glycogen synthesis in dexamethasone-treated 3T3 adipocytes: evidence for a novel insulin sensitizing action.
Insulin Resistance
Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts.
Insulin Resistance
Effects of Bushen Tongmai Recipe on protein kinase Balpha expression in polycystic ovary rats with insulin resistance.
Insulin Resistance
Effects of dexamethasone administration on insulin resistance and components of insulin signaling and glucose metabolism in equine skeletal muscle.
Insulin Resistance
Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice.
Insulin Resistance
Effects of pomegranate aril juice and its punicalagin on some key regulators of insulin resistance and oxidative liver injury in streptozotocin-nicotinamide type 2 diabetic rats.
Insulin Resistance
Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes.
Insulin Resistance
Effects of seasonal adiposity on ovarian activity of Vespertilionid bat, Scotophilus heathi: proteomics analysis.
Insulin Resistance
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.
Insulin Resistance
Emerging role of JNK in insulin resistance.
Insulin Resistance
Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes.
Insulin Resistance
Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscle.
Insulin Resistance
Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome.
Insulin Resistance
Evidence for altered insulin signalling in the brains of genetic absence epilepsy rats from Strasbourg.
Insulin Resistance
Evidence for tuning adipocytes ICER levels for obesity care.
Insulin Resistance
Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression.
Insulin Resistance
Exercise Intensity, Inflammatory Signaling and Insulin Resistance in Obese Rats.
Insulin Resistance
Exercise training-induced improvements in insulin action.
Insulin Resistance
Expression of S6K1 in human visceral adipose tissue is upregulated in obesity and related to insulin resistance and inflammation.
Insulin Resistance
Fas-Associated Factor 1 Promotes Hepatic Insulin Resistance via JNK Signaling Pathway.
Insulin Resistance
Fibroblast Growth Factor-1 Improves Insulin Resistance via Repression of JNK-Mediated Inflammation.
Insulin Resistance
Flaxseed Oil Attenuates Hepatic Steatosis and Insulin Resistance in Mice by Rescuing the Adaption to ER Stress.
Insulin Resistance
Free fatty acid-induced H2O2 activates TRPM2 to aggravate endothelial insulin resistance via Ca2+-dependent PERK/ATF4/TRB3 cascade in obese mice.
Insulin Resistance
Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment.
Insulin Resistance
Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression.
Insulin Resistance
Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes.
Insulin Resistance
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
Insulin Resistance
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Insulin Resistance
Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet.
Insulin Resistance
Gestational glucocorticoid exposure disrupts glucose homeostasis that is accompanied by increased endoglin and DPP-4 activity instead of GSK-3 in rats.
Insulin Resistance
Gestational Protein Restriction impairs Glucose Disposal in the Gastrocnemius muscles of Female Rats.
Insulin Resistance
Ginsenoside Mc1 improves liver steatosis and insulin resistance by attenuating ER stress.
Insulin Resistance
Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signalling and the effects of a selective glycogen synthase kinase-3 inhibitor.
Insulin Resistance
Glucocorticoid-induced insulin resistance of protein synthesis is independent of the rapamycin-sensitive pathways in rat skeletal muscle.
Insulin Resistance
Glucocorticoids antagonize tumor necrosis factor-?-stimulated lipolysis and resistance to the antilipolytic effect of insulin in human adipocytes.
Insulin Resistance
Glutaredoxin 2 (GRX2) deficiency exacerbates high fat diet (HFD)-induced insulin resistance, inflammation and mitochondrial dysfunction in brain injury: A mechanism involving GSK-3?.
Insulin Resistance
Glycemic index differences of high-fat diets modulate primarily lipid metabolism in murine adipose tissue.
Insulin Resistance
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.
Insulin Resistance
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism.
Insulin Resistance
Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review.
Insulin Resistance
Glycogen synthase kinase-3 - a promising therapeutic target: Dr Hagit Eldar-Finkelman interviewed by Emma Quigley.
Insulin Resistance
GSK3 involvement in amylin signaling in isolated rat soleus muscle.
Insulin Resistance
Gut Microbiota Regulates the Interaction between Diet and Genetics to Influence Glucose Tolerance.
Insulin Resistance
Hepatic Expression of Phosphorylated Kinase Akt and Glycogen Synthase Kinase-3 Isoforms in Patients with Chronic Hepatitis C.
Insulin Resistance
Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
Insulin Resistance
Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance.
Insulin Resistance
Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3ß signaling in hepatocytes.
Insulin Resistance
Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance.
Insulin Resistance
High glucose and insulin in combination cause insulin receptor substrate-1 and -2 depletion and protein kinase B desensitisation in primary cultured rat adipocytes: possible implications for insulin resistance in type 2 diabetes.
Insulin Resistance
High glucose impairs insulin signaling via activation of PKR pathway in L6 muscle cells.
Insulin Resistance
High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates.
Insulin Resistance
High-Efficacy ?,?-Dehydromonacolin S Improves Hepatic Steatosis and Suppresses Gluconeogenesis Pathway in High-Fat Diet-Induced Obese Rats.
Insulin Resistance
High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle.
Insulin Resistance
High-fat diet induced adiposity and insulin resistance in mice lacking the myotonic dystrophy protein kinase.
Insulin Resistance
Higher insulin sensitivity in EDL muscle of rats fed a low-protein, high-carbohydrate diet inhibits the caspase-3 and ubiquitin-proteasome proteolytic systems but does not increase protein synthesis.
Insulin Resistance
Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1.
Insulin Resistance
HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients.
Insulin Resistance
Hot topic: Ceramide inhibits insulin sensitivity in primary bovine adipocytes.
Insulin Resistance
Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue.
Insulin Resistance
Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle.
Insulin Resistance
Hypoglycemic Activity and Antioxidative Stress of Extracts and Corymbiferin from Swertia bimaculata In Vitro and In Vivo.
Insulin Resistance
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism.
Insulin Resistance
Identification of enhanced serine kinase activity in insulin resistance.
Insulin Resistance
Identification of Hipk2 as an essential regulator of white fat development.
Insulin Resistance
IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNF? expression in human subcutaneous preadipocytes.
Insulin Resistance
Imoxin attenuates high fructose-induced oxidative stress and apoptosis in renal epithelial cells via downregulation of protein kinase R pathway.
Insulin Resistance
Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment.
Insulin Resistance
Impaired overload-induced hypertrophy is associated with diminished mTOR signaling in insulin resistant skeletal muscle of the obese Zucker rat.
Insulin Resistance
Improved insulin-stimulated glucose uptake and glycogen synthase activation in rat skeletal muscles after adrenaline infusion: role of glycogen content and PKB phosphorylation.
Insulin Resistance
In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity.
Insulin Resistance
In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes.
Insulin Resistance
In vivo effects of insulin and bis(maltolato)oxovanadium (IV) on PKB activity in the skeletal muscle and liver of diabetic rats.
Insulin Resistance
In vivo JNK activation in pancreatic ?-cells leads to glucose intolerance caused by insulin resistance in pancreas.
Insulin Resistance
In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.
Insulin Resistance
Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation.
Insulin Resistance
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.
Insulin Resistance
Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit.
Insulin Resistance
Inflammation and endoplasmic reticulum stress in obesity and diabetes.
Insulin Resistance
Inhibition of Aurora-A improves insulin resistance by ameliorating islet inflammation and controlling interleukin-6 in a diabetic mouse model.
Insulin Resistance
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes.
Insulin Resistance
Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc.
Insulin Resistance
Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells.
Insulin Resistance
Inhibition of protein kinase B by palmitate in the insulin signaling of HepG2 cells and the preventive effect of arachidonic acid on insulin resistance.
Insulin Resistance
Inhibitory effects of dioscorea polysaccharide on TNF-? induced insulin resistance in the mouse FL83B cells.
Insulin Resistance
Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.
Insulin Resistance
Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.
Insulin Resistance
Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.
Insulin Resistance
Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review.
Insulin Resistance
Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4.
Insulin Resistance
Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the level of phosphorylation of IRS1 in type 2 diabetes.
Insulin Resistance
Insulin resistance, microbiota and fat distribution changes by a new model of vertical sleeve gastrectomy in obese rats.
Insulin Resistance
Insulin sensitization of MAP kinase signaling by fibroin in insulin-resistant Hirc-B cells.
Insulin Resistance
Insulin Signaling, GSK-3, Heat Shock Proteins and the Natural History of Type 2 Diabetes Mellitus: A Hypothesis.
Insulin Resistance
Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.
Insulin Resistance
Interleukin-1? inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts.
Insulin Resistance
Intramuscular Injection of miR-1 Reduces Insulin Resistance in Obese Mice.
Insulin Resistance
Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice.
Insulin Resistance
Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition.
Insulin Resistance
JNK activity in subcutaneous adipose tissue but not NF{kappa}B activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals.
Insulin Resistance
JNK signaling pathway in metabolic disorders: An emerging therapeutic target.
Insulin Resistance
JNK/PI3K/Akt signaling pathway is involved in myocardial ischemia/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention.
Insulin Resistance
JNK1 but not JNK2 promotes the development of steatohepatitis in mice.
Insulin Resistance
Knockout of CNR1 prevents metabolic stress-induced cardiac injury through improving insulin resistance (IR) injury and endoplasmic reticulum (ER) stress by promoting AMPK-alpha activation.
Insulin Resistance
LECT2 induces atherosclerotic inflammatory reaction via CD209 receptor-mediated JNK phosphorylation in human endothelial cells.
Insulin Resistance
LECT2 promotes inflammation and insulin resistance in adipocytes via P38 pathways.
Insulin Resistance
Leptin, skeletal muscle lipids, and lipid-induced insulin resistance.
Insulin Resistance
Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure.
Insulin Resistance
Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance.
Insulin Resistance
Long noncoding RNA MALAT1 regulates generation of reactive oxygen species and the insulin responses in male mice.
Insulin Resistance
Long-Term Treatment with Novel Glycogen Synthase Kinase-3 Inhibitor Improves Glucose Homeostasis in ob/ob Mice: Molecular Characterization in Liver and Muscle.
Insulin Resistance
Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity.
Insulin Resistance
Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.
Insulin Resistance
Low salt intake modulates insulin signaling, JNK activity and IRS-1ser307 phosphorylation in rat tissues.
Insulin Resistance
LPS-induced biomarkers in mice: a potential model for identifying insulin sensitizers.
Insulin Resistance
LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes.
Insulin Resistance
Maintenance of metabolic homeostasis by sestrin2 and sestrin3.
Insulin Resistance
Maternal exercise modifies body composition and energy substrates handling in male offspring fed a high-fat/high-sucrose diet.
Insulin Resistance
Maternal hypoxia increases the susceptibility of adult rat male offspring to high-fat diet-induced non-alcoholic fatty liver disease.
Insulin Resistance
Maternal periodontitis decreases plasma membrane GLUT4 content in skeletal muscle of adult offspring.
Insulin Resistance
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.
Insulin Resistance
Mechanism of attenuation of skeletal muscle atrophy by zinc-alpha2-glycoprotein.
Insulin Resistance
Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings.
Insulin Resistance
Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein.
Insulin Resistance
Metformin: a cheap and well-tolerated drug that provides benefits for viral infections.
Insulin Resistance
Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice.
Insulin Resistance
Mizoribine-induced severe hyperglycemia in a patient with microscopic polyangiitis.
Insulin Resistance
Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty rats.
Insulin Resistance
Modulation of the JNK pathway in liver affects insulin resistance status.
Insulin Resistance
Molecular and cellular mechanisms linking inflammation to insulin resistance and ?-cell dysfunction.
Insulin Resistance
Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome.
Insulin Resistance
Molecular mechanisms of insulin resistance in chronic kidney disease.
Insulin Resistance
Molecular mechanisms of insulin resistance in type 2 diabetes mellitus.
Insulin Resistance
Molecular mechanisms of insulin resistance.
Insulin Resistance
Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions.
Insulin Resistance
mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes.
Insulin Resistance
Mulberry leaf extract displays antidiabetic activity in db/db mice via Akt and AMP-activated protein kinase phosphorylation.
Insulin Resistance
Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity.
Insulin Resistance
Muscle adaptation to short-term fasting in healthy lean humans.
Insulin Resistance
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Insulin Resistance
Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice.
Insulin Resistance
Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway.
Insulin Resistance
Nitrate attenuates high fat diet-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission.
Insulin Resistance
NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance.
Insulin Resistance
Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.
Insulin Resistance
Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR.
Insulin Resistance
Novel roles for JNK1 in metabolism.
Insulin Resistance
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.
Insulin Resistance
Omega-3 polyunsaturated fatty acids prevent obesity by improving tricarboxylic acid cycle homeostasis.
Insulin Resistance
Oral hormonal therapy with ethinylestradiol/levonorgestrel improves insulin resistance, obesity and glycogen synthase kinase-3 independent of circulating mineralocorticoid in estrogen-deficient rats.
Insulin Resistance
Oral treatment with vanadium of Zucker fatty rats activates muscle glycogen synthesis and insulin-stimulated protein phosphatase-1 activity.
Insulin Resistance
Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.
Insulin Resistance
Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation.
Insulin Resistance
Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3.
Insulin Resistance
Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation.
Insulin Resistance
p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus.
Insulin Resistance
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.
Insulin Resistance
P7C3-A20, a neuroprotective agent, alleviates fatty liver by inducing FGF21/FGF1 in a LKB1/AMPK/CRTC2-dependent manner and shaping gut microbiota.
Insulin Resistance
Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells.
Insulin Resistance
Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus.
Insulin Resistance
Pathogenic Role of Scavenger Receptor CD36 in the Metabolic Syndrome and Diabetes.
Insulin Resistance
Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review.
Insulin Resistance
PCBP2 regulates hepatic insulin sensitivity via HIF-1? and STAT3 pathway in HepG2 cells.
Insulin Resistance
Perfluorooctane sulfonate-induced insulin resistance is mediated by protein kinase B pathway.
Insulin Resistance
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice.
Insulin Resistance
Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRbeta/IRS-1 and Akt.
Insulin Resistance
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.
Insulin Resistance
Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action.
Insulin Resistance
Photobiomodulation therapy ameliorates hyperglycemia and insulin resistance by activating cytochrome c oxidase-mediated protein kinase B in muscle.
Insulin Resistance
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Insulin Resistance
Potent anti-diabetic effects of MHY908, a newly synthesized PPAR ?/? dual agonist in db/db mice.
Insulin Resistance
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
Insulin Resistance
PPTR-1 counterAkts insulin signaling.
Insulin Resistance
PRDX1 is involved in palmitate induced insulin resistance via regulating the activity of p38MAPK in HepG2 cells.
Insulin Resistance
Prevention of fat-induced insulin resistance by salicylate.
Insulin Resistance
Propranolol Improves Impaired Hepatic PI3K/Akt Signaling Post Burn Injury.
Insulin Resistance
Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans.
Insulin Resistance
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.
Insulin Resistance
Psoralea corylifolia L. Seed Extract Attenuates Methylglyoxal-Induced Insulin Resistance by Inhibition of Advanced Glycation End Product Formation.
Insulin Resistance
Purple sweet potato color improves hippocampal insulin resistance via down-regulating SOCS3 and galectin-3 in high-fat diet mice.
Insulin Resistance
Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance.
Insulin Resistance
Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance.
Insulin Resistance
Reducing hepatic endoplasmic reticulum stress ameliorates the impairment in insulin signaling induced by high levels of ?-hydroxybutyrate in bovine hepatocytes.
Insulin Resistance
Regulation of insulin receptor substrate-2 tyrosine phosphorylation in animal models of insulin resistance.
Insulin Resistance
Regulation of IRS-2 tyrosine phosphorylation in fasting and diabetes.
Insulin Resistance
Regulatory effects of hawthorn polyphenols on hyperglycemic, inflammatory, insulin resistance responses, and alleviation of aortic injury in type 2 diabetic rats.
Insulin Resistance
Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance.
Insulin Resistance
Resveratrol regulates neuronal glucose uptake and insulin sensitivity via P21-activated kinase 2 (PAK2).
Insulin Resistance
Rho kinase/AMPK axis regulates hepatic lipogenesis during overnutrition.
Insulin Resistance
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Insulin Resistance
ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance.
Insulin Resistance
ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity.
Insulin Resistance
Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.
Insulin Resistance
Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells.
Insulin Resistance
Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.
Insulin Resistance
Role of glycogen synthase kinase-3 in skeletal muscle insulin resistance in Type 2 diabetes.
Insulin Resistance
Role of Glycogen synthase kinase-3 in the etiology of Type 2 Diabetes Mellitus: A review.
Insulin Resistance
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance.
Insulin Resistance
Roles of p38-MAPK in insulin resistant heart: evidence from bench for future bedside application.
Insulin Resistance
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance.
Insulin Resistance
Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
Insulin Resistance
Selective impairment in glycogen synthase kinase-3 and mitogen-activated protein kinase phosphorylation: comparisons with the hyperandrogenic and the hyperinsulinemic rats.
Insulin Resistance
Sensing the insulin signaling pathway with an antibody array.
Insulin Resistance
Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.
Insulin Resistance
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.
Insulin Resistance
Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in people with newly diagnosed T2DM.
Insulin Resistance
Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats.
Insulin Resistance
Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply.
Insulin Resistance
Skeletal muscle insulin resistance induced by adipocyte-conditioned medium: underlying mechanisms and reversibility.
Insulin Resistance
Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice.
Insulin Resistance
Sonchus oleraceus Linn extract enhanced glucose homeostasis through the AMPK/Akt/ GSK-3? signaling pathway in diabetic liver and HepG2 cell culture.
Insulin Resistance
Sterol O-acyltransferase 1 deficiency improves defective insulin signaling in the brains of mice fed a high-fat diet.
Insulin Resistance
STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue.
Insulin Resistance
Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet-fed mice.
Insulin Resistance
Suppression of Rho-kinase 1 is responsible for insulin regulation of the AMPK/SREBP-1c pathway in skeletal muscle cells exposed to palmitate.
Insulin Resistance
Sustained ?AR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner.
Insulin Resistance
Targeted disruption of ROCK1 causes insulin resistance in vivo.
Insulin Resistance
Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes.
Insulin Resistance
Targeting glycogen synthase kinase-3 in insulin signalling.
Insulin Resistance
Temporal Relationship between Diet-Induced Steatosis and Onset of Insulin/Leptin Resistance in Male Wistar Rats.
Insulin Resistance
The ABCG5 ABCG8 Sterol Transporter Opposes the Development of Fatty Liver Disease and Loss of Glycemic Control Independently of Phytosterol Accumulation.
Insulin Resistance
The c-Jun N-Terminal Kinase Mediates the Induction of Oxidative Stress and Insulin Resistance by Palmitate and Toll-like Receptor 2 and 4 Ligands in 3T3-L1 Adipocytes.
Insulin Resistance
The consequences of long-term glycogen synthase kinase-3 inhibition on normal and insulin resistant rat hearts.
Insulin Resistance
The expression of CCN2, IQSEC, RSPO1, DNAJC15, RIPK2, IL13RA2, IRS1, and IRS2 genes in blood of obese boys with insulin resistance.
Insulin Resistance
The high-fat-fed lean Zucker rat: a spontaneous isocaloric model of fat-induced insulin resistance associated with muscle GSK-3 overactivity.
Insulin Resistance
The hypothalamus bridges the gap between physiology and biochemistry in high-fat diet-induced hepatic insulin resistance.
Insulin Resistance
The Impact of Differentiation on Cytotoxicity and Insulin Sensitivity in Streptozotocin Treated SH-SY5Y Cells.
Insulin Resistance
The Impact of Substance P on the Pathogenesis of Insulin Resistance Leading to Gestational Diabetes.
Insulin Resistance
The JNK pathway as a therapeutic target for diabetes.
Insulin Resistance
The key role of Akt protein kinase in metabolic-inflammatory pathways cross-talk: TNF-? down-regulation and improving of insulin resistance in HepG2 cell line.
Insulin Resistance
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Insulin Resistance
The regulation of human p450c17 activity: relationship to premature adrenarche, insulin resistance and the polycystic ovary syndrome.
Insulin Resistance
The Role of Bone Morphogenetic Proteins in Diabetic Complications.
Insulin Resistance
The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.
Insulin Resistance
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.
Insulin Resistance
Therapeutic potential of dithiolethiones for hepatic diseases.
Insulin Resistance
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Insulin Resistance
Therapeutic Strategies to Increase Human ?-Cell Growth and Proliferation by Regulating mTOR and GSK-3/?-Catenin Pathways.
Insulin Resistance
Tissue-specific analysis of glycogen synthase kinase-3? (GSK-3?) in glucose metabolism: effect of strain variation.
Insulin Resistance
Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury.
Insulin Resistance
Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes.
Insulin Resistance
Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue.
Insulin Resistance
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.
Insulin Resistance
Trilobatin ameliorates insulin resistance through IRS-AKT-GLUT4 signaling pathway in C2C12 myotubes and ob/ob mice.
Insulin Resistance
Tumor Necrosis Factor-Induced Cerebral Insulin Resistance in Alzheimer's Disease Links Numerous Treatment Rationales.
Insulin Resistance
Up-regulation of Toll-like receptor 4/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation.
Insulin Resistance
Upregulation of IL-4 signaling contributes to aerobic exercise-induced insulin sensitivity.
Insulin Resistance
Vitamin C deficiency aggravates tumor necrosis factor ?-induced insulin resistance.
Insulin Resistance
Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion.
Insulin Resistance
Xenobiotic mediated diabetogenesis: Developmental exposure to dichlorvos or atrazine leads to type 1 or type 2 diabetes in Drosophila.
Insulin Resistance
Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice.
Insulin Resistance
[A new target for diabetes therapy: advances in the research of glycogen synthase kinase-3 inhibitors]
Insulin Resistance
[Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease].
Insulin Resistance
[Amelioration of insulin resistance after scald by c-Jun N-terminal kinase inhibitor in rat]
Insulin Resistance
[Effect of Acupuncture on Reproductive Endocrine and p-Akt Protein Expression in Polycystic Ovary Syndrome Rats with Insulin Resistance].
Insulin Resistance
[Effects of L-Arg on expression of PI3K and PKB in liver among low-birth-weight newborn rats].
Insulin Resistance
[Genetic testing of constitutive sensitivity to metformin in cancer patients with and without diabetes].
Insulinoma
Akt/p27kip1 Pathway Is Not Involved in Human Insulinoma Tumorigenesis.
Insulinoma
Ca2+/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells.
Insulinoma
Ca2+/calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells.
Insulinoma
Calpain inhibitor and ibudilast rescue ? cell functions in a cellular model of Wolfram syndrome.
Insulinoma
Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells.
Insulinoma
Expression, intracellular localization, and gene transcription regulation of the secretory protein 7B2 in endocrine pancreatic cell lines and human insulinomas.
Insulinoma
Growth factor receptor expression in human gastroenteropancreatic neuroendocrine tumours.
Insulinoma
Inhibition of SH2-domain containing inositol phosphatase 2 (SHIP2) in insulin producing INS1E cells improves insulin signal transduction and induces proliferation.
Insulinoma
Insulinoma Cells Contain an Isoform of Ca2+/Calmodulin-Dependent Protein Kinase II ? Associated with Insulin Secretion Vesicles.
Insulinoma
Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles.
Insulinoma
Mesenchymal stem cell (MSC)-mediated survival of insulin producing pancreatic ?-cells during cellular stress involves signalling via Akt and ERK1/2.
Insulinoma
Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation.
Insulinoma
New aspects of neurotransmitter release and exocytosis: involvement of Ca2+/calmodulin-dependent phosphorylation of synapsin I in insulin exocytosis.
Insulinoma
Regulation of insulin secretion by overexpression of Ca2+/calmodulin-dependent protein kinase II in insulinoma MIN6 cells.
Insulinoma
The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition.
Intellectual Disability
A protein implicated in non-syndromic mental retardation regulates the protein kinase a (PKA) activity.
Intellectual Disability
An Xp22.12 microduplication including RPS6KA3 identified in a family with variably affected intellectual and behavioral disabilities.
Intellectual Disability
Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties.
Intellectual Disability
CASK and CaMKII function in Drosophila memory.
Intellectual Disability
CNKSR1 gene defect can cause syndromic autosomal recessive intellectual disability.
Intellectual Disability
Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31.
Intellectual Disability
De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features.
Intellectual Disability
Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome.
Intellectual Disability
Developmental changes in expression of myotonic dystrophy protein kinase in the rat central nervous system.
Intellectual Disability
Disruption of the serine/threonine kinase 9 gene causes severe X-linked infantile spasms and mental retardation.
Intellectual Disability
Evaluating the Role of MAST1 as an Intellectual Disability Disease Gene: Identification of a Novel De Novo Variant in a Patient with Developmental Disabilities.
Intellectual Disability
Expression of the RSK2 gene during early human development.
Intellectual Disability
Extending the phenotype associated with the CSNK2A1-related Okur-Chung syndrome-A clinical study of 11 individuals.
Intellectual Disability
FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control.
Intellectual Disability
Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes of down syndrome patients.
Intellectual Disability
Identification of a New Mutation in RSK2, the Gene for Coffin-Lowry Syndrome (CLS), in Two Related Patients with Mild and Atypical Phenotypes.
Intellectual Disability
Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons.
Intellectual Disability
Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1.
Intellectual Disability
Missense mutations in CASK, coding for the calcium-/calmodulin-dependent serine protein kinase, interfere with neurexin binding and neurexin-induced oligomerization.
Intellectual Disability
Missense substitutions at a conserved 14-3-3 binding site in HDAC4 cause a novel intellectual disability syndrome.
Intellectual Disability
Negative-feedback inhibition of NFATc1 by DYRK1A regulates bone homeostasis.
Intellectual Disability
Prenatal diagnosis in Coffin-Lowry syndrome demonstrates germinal mosaicism confirmed by mutation analysis.
Intellectual Disability
Regulation of Dyrk1A kinase activity by 14-3-3.
Intellectual Disability
TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene.
Intellectual Disability
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Intellectual Disability
The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A.
Intellectual Disability
Transcriptome profile reveals AMPA receptor dysfunction in the hippocampus of the Rsk2-knockout mice, an animal model of Coffin-Lowry syndrome.
Intellectual Disability
Ulk4 regulates GABAergic signaling and anxiety-related behavior.
Intervertebral Disc Degeneration
Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration.
Intervertebral Disc Degeneration
Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration.
Intervertebral Disc Degeneration
RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs.
Intervertebral Disc Degeneration
Sparstolonin B prevents lumbar intervertebral disc degeneration through toll like receptor 4, NADPH oxidase activation and the protein kinase B signaling pathway.
Intestinal Diseases
AMP-activated protein kinase: a therapeutic target in intestinal diseases.
Intestinal Obstruction
Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease.
Intestinal Polyposis
Findings from the Peutz-Jeghers syndrome registry of uruguay.
Intestinal Pseudo-Obstruction
Inhibition of protein kinase A in murine enteric neurons causes lethal intestinal pseudo-obstruction.
Intestinal Pseudo-Obstruction
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Intracranial Aneurysm
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Intracranial Aneurysm
MicroRNA-29b targeting of cell division cycle 7-related protein kinase (CDC7) regulated vascular smooth muscle cell (VSMC) proliferation and migration.
Intracranial Aneurysm
Particularly interesting Cys-His-rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture.
Intracranial Aneurysm
Regulatory mechanism of MiR-21 in formation and rupture of intracranial aneurysm through JNK signaling pathway-mediated inflammatory response.
Intracranial Hemorrhages
Association of the TLR4-MyD88-JNK signaling pathway with inflammatory response in intracranial hemorrhage rats and its effect on neuronal apoptosis.
Intracranial Hemorrhages
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Intussusception
Extremely young case of small bowel intussusception due to Peutz-Jeghers syndrome with nonsense mutation of STK11.
Intussusception
Peutz-Jeghers syndrome with germline mutation of STK11.
Intussusception
STK11 status and intussusception risk in Peutz-Jeghers syndrome.
Intussusception
[Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome].
Iron Deficiencies
Dietary iron deficiency impaired intestinal immune function of on-growing grass carp under the infection of Aeromonas hydrophila: Regulation of NF-?B and TOR signaling.
Iron Deficiencies
Expression profiling of the 14-3-3 gene family in response to salt stress and potassium and iron deficiencies in young tomato (Solanum lycopersicum) roots: analysis by real-time RT-PCR.
Iron Deficiencies
Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus.
Iron Deficiencies
pkn22 (alr2502) encoding a putative Ser/Thr kinase in the cyanobacterium Anabaena sp. PCC 7120 is induced by both iron starvation and oxidative stress and regulates the expression of isiA.
Iron Deficiencies
The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-?B, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngodon idella).
Iron Deficiencies
The impaired immune function and structural integrity by dietary iron deficiency or excess in gill of fish after infection with Flavobacterium columnare: Regulation of NF-?B, TOR, JNK, p38MAPK, Nrf2 and MLCK signalling.
Iron Overload
Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis.
Ischemic Attack, Transient
Alterations of Ca2+/calmodulin-dependent protein kinase II and its messenger RNA in the rat hippocampus following normo- and hypothermic ischemia.
Ischemic Attack, Transient
Increased phosphorylation of the NR1 subunit of the NMDA receptor following cerebral ischemia.
Ischemic Stroke
14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients.
Ischemic Stroke
c-Jun N-Terminal Kinase Pathway Inhibition in Intracerebral Hemorrhage.
Ischemic Stroke
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Ischemic Stroke
cPKC?-Modulated Autophagy in Neurons Alleviates Ischemic Injury in Brain of Mice with Ischemic Stroke Through Akt-mTOR Pathway.
Ischemic Stroke
Cyclin-dependent kinase-5 targeting for ischaemic stroke.
Ischemic Stroke
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Ischemic Stroke
Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor.
Ischemic Stroke
Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production.
Ischemic Stroke
GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke.
Ischemic Stroke
H2S attenuates injury after ischemic stroke by diminishing the assembly of CaMKII with ASK1-MKK3-p38 signaling module.
Ischemic Stroke
Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening.
Ischemic Stroke
Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.
Ischemic Stroke
Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions.
Ischemic Stroke
Investigating the Protective Effect of Gross Saponins of Tribulus terrestris Fruit against Ischemic Stroke in Rat Using Metabolomics and Network Pharmacology.
Ischemic Stroke
JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke.
Ischemic Stroke
miR?335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke.
Ischemic Stroke
Oxidative CaMKII as a potential target for inflammatory disease (Review).
Ischemic Stroke
Pien-Tze-Huang protects cerebral ischemic injury by inhibiting neuronal apoptosis in acute ischemic stroke rats.
Ischemic Stroke
Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models.
Ischemic Stroke
Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke.
Ischemic Stroke
Protective Effect of Aliskiren in Experimental Ischemic Stroke: Up-Regulated p-PI3K, p-AKT, Bcl-2 Expression, Attenuated Bax Expression.
Ischemic Stroke
Serial Magnetic Resonance Imaging in Creutzfeldt-Jakob Disease: a Case Report and Literature Review.
Ischemic Stroke
Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke.
Ischemic Stroke
The pathophysiological mechanism of ischemic stroke after hypobaric hypoxia simulation at high altitude.
Ischemic Stroke
The protective effect of bone marrow mesenchymal stem cells in a rat model of ischemic stroke via reducing the C-Jun N-terminal kinase expression.
Ischemic Stroke
Therapeutic effects of JLX-001 on ischemic stroke by inducing autophagy via AMPK-ULK1 signaling pathway in rats.
Joint Diseases
Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis.
Joint Diseases
Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation.
Kallmann Syndrome
The breakpoint identified in a balanced de novo translocation t(7;9)(p14.1;q31.3) disrupts the A-kinase (PRKA) anchor protein 2 gene (AKAP2) on chromosome 9 in a patient with Kallmann syndrome and bone anomalies.
Kashin-Beck Disease
Effects of sodium selenite on c-Jun N-terminal kinase signalling pathway induced by oxidative stress in human chondrocytes and c-Jun N-terminal kinase expression in patients with Kashin-Beck disease, an endemic osteoarthritis.
Keloid
Activation of ERK and p38 kinase mediated keloid fibroblast apoptosis after flashlamp pulsed-dye laser treatment.
Keloid
Chondroitin Sulfate Promotes the Proliferation of Keloid Fibroblasts Through Activation of the Integrin and Protein Kinase B Pathways.
Keloid
Differential Expression of Hedgehog and Snail in Cutaneous Fibrosing Disorders: Implications for Targeted Inhibition.
Keloid
Downregulation of ?-catenin blocks fibrosis via Wnt2 signaling in human keloid fibroblasts.
Keloid
Improving the anti-keloid outcomes through liposomes loading paclitaxel-cholesterol complexes.
Keloid
Inhibition of microRNA-21-5p reduces keloid fibroblast autophagy and migration by targeting PTEN after electron beam irradiation.
Keloid
Mechanisms of MAPK pathway mediating TGF-beta(1)/Smad signal in keloid fibroblasts.
Keloid
MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.
Keloid
Role of Homeodomain-Interacting Protein Kinase 2 in the Pathogenesis of Tissue Fibrosis in Keloid-Derived Keratinocytes.
Keloid
Wnt Signaling Pathway Proteins in Scar, Hypertrophic Scar, and Keloid: Evidence for a Continuum?
Keloid
Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway.
Keloid
[Expressions of the related genes in fibroblasts of human keloid and the effect of artesunate].
Keratitis
Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis.
Keratitis
Mammalian Ste20-like kinase 4 inhibits the inflammatory response in Aspergillus fumigatus keratitis.
Keratitis
Regulation of the catalytic activity of herpes simplex virus 1 protein kinase Us3 by autophosphorylation and its role in pathogenesis.
Keratoacanthoma
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
Keratoacanthoma
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity.
Keratoacanthoma
Multiple squamous cell carcinomas of the skin after therapy with sorafenib combined with tipifarnib.
Keratoacanthoma
Mutational analysis of the HIPK2 gene in keratoacanthoma and squamous cell carcinoma of the skin.
Keratosis
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
Keratosis
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity.
Keratosis, Actinic
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
Keratosis, Actinic
Multiple squamous cell carcinomas of the skin after therapy with sorafenib combined with tipifarnib.
Ketosis
Diet-Induced Ketosis Protects Against Focal Cerebral Ischemia in Mouse.
Ketosis
Phenotypic and genetic relationships of common health disorders with milk and fat yield persistencies from producer-recorded health data and test-day yields.
Kidney Calculi
HIPK2 polymorphisms rs2058265, rs6464214, and rs7456421 were associated with kidney stone disease in Chinese males not females.
Kidney Diseases
A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-?1/Smad3 Pathway.
Kidney Diseases
A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.
Kidney Diseases
Glycogen synthase kinase 3beta: a novel marker and modulator of inflammatory injury in chronic renal allograft disease.
Kidney Diseases
Hepatocyte Growth Factor Suppresses Proinflammatory NF{kappa}B Activation through GSK3{beta} Inactivation in Renal Tubular Epithelial Cells.
Kidney Diseases
HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease.
Kidney Diseases
Inhibition of apoptosis signal-regulating kinase 1 mitigates the pathogenesis of human immunodeficiency virus-associated nephropathy.
Kidney Diseases
Interconnected network motifs control podocyte morphology and kidney function.
Kidney Diseases
Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
Kidney Diseases
No associations between rs2030712 and rs7456421 single nucleotide polymorphisms of HIPK2 gene and prevalence of chronic kidney disease. Results of a family-based study.
Kidney Diseases
Renoprotective Effects of a Novel Receptor-Interacting Protein Kinase 2 Inhibitor, AS3334034, in Uninephrectomized Adriamycin-Induced Chronic Kidney Disease Rats.
Kidney Diseases
Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice.
Kidney Diseases
Targeting mammalian serine/threonine-protein kinase 4 through Yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis.
Kidney Diseases
Tubular HIPK2 is a key contributor to renal fibrosis.
Kidney Diseases, Cystic
CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis.
Kidney Diseases, Cystic
High-resolution genetic localization of a modifying locus affecting disease severity in the juvenile cystic kidneys (jck) mouse model of polycystic kidney disease.
Kidney Diseases, Cystic
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.
Kidney Diseases, Cystic
Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease.
Kidney Failure, Chronic
Renoprotective Effects of a Novel Receptor-Interacting Protein Kinase 2 Inhibitor, AS3334034, in Uninephrectomized Adriamycin-Induced Chronic Kidney Disease Rats.
Kidney Failure, Chronic
Up-regulation of the gene encoding protein kinase A type I alpha regulatory subunit in nodular hyperplasia of parathyroid glands in patients with chronic renal failure.
Kidney Neoplasms
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis.
Kidney Neoplasms
CAV2 promotes the growth of renal cell carcinoma through the EGFR/PI3K/Akt pathway.
Kidney Neoplasms
Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide.
Kidney Neoplasms
Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells.
Kidney Neoplasms
Dual degradation of aurora A and B kinases by the histone deacetylase inhibitor LBH589 induces G2-M arrest and apoptosis of renal cancer cells.
Kidney Neoplasms
Effect of Target Therapy on the Content of Transcription and Growth Factors, Protein Kinase TOR, and Activity of Intracellular Proteases in Patients with Metastatic Renal Cell Carcinoma.
Kidney Neoplasms
Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma.
Kidney Neoplasms
Glycogen Synthase Kinase-3{beta}: A Prognostic Marker and a Potential Therapeutic Target in Human Bladder Cancer.
Kidney Neoplasms
Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer.
Kidney Neoplasms
MicroRNA-124 (MiR-124) Inhibits Cell Proliferation, Metastasis and Invasion in Colorectal Cancer by Downregulating Rho-Associated Protein Kinase 1(ROCK1).
Kidney Neoplasms
Multiple roles and therapeutic implications of Akt signaling in cancer.
Kidney Neoplasms
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Kidney Neoplasms
Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a?p-AKT-dependent manner.
Kidney Neoplasms
RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma.
Kidney Neoplasms
Safety and Efficacy of Sorafenib Therapy in Patients With Metastatic Kidney Cancer With Impaired Renal Function.
Kidney Neoplasms
SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.
Kidney Neoplasms
Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation.
Labyrinth Diseases
Proto-oncogene Raf-1 as an autoantigen in Meniere's disease.
Lacrimal Apparatus Diseases
?-adrenoceptor activation increased VAMP-2 and syntaxin-4 in secretory granules are involved in protein secretion of submandibular gland through the PKA/F-actin pathway.
Lacrimal Apparatus Diseases
Decreased interaction between ZO-1 and occludin is involved in alteration of tight junctions in transplanted epiphora submandibular glands.
Laminopathies
The Cutting Edge: The Role of mTOR Signaling in Laminopathies.
Language Development Disorders
Ulk4 regulates GABAergic signaling and anxiety-related behavior.
Laryngeal Neoplasms
[Effect of miR-340-5p on proliferation of laryngeal cancer Hep2 cells and its intrinsic molecular mechanism].
Learning Disabilities
Decreased calcium/calmodulin-dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long-term potentiation in the olfactory bulbectomized mice.
Learning Disabilities
Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.
Learning Disabilities
Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice.
Learning Disabilities
[Dysfunction of Na+/Ca2+ exchangers is associated with cognitive decline in Alzheimer's disease].
Leiomyoma
7q deletion mapping and expression profiling in uterine fibroids.
Leiomyoma
A-Kinase Anchoring Protein 13 (AKAP13) Augments Progesterone Signaling in Uterine Fibroid Cells.
Leiomyoma
Aberrant Akt Activation During Implantation Window in Infertile Women With Intramural Uterine Fibroids.
Leiomyoma
Activation of protein kinase B by WNT4 as a regulator of uterine leiomyoma stem cell function.
Leiomyoma
Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology.
Leiomyoma
Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice.
Leiomyoma
Differential expression of Akt/protein kinase B, Bcl-2 and Bax proteins in human leiomyoma and myometrium.
Leiomyoma
Down-regulation and gene hypermethylation of the 14-3-3 gamma in uterine leiomyoma.
Leiomyoma
Evaluation of 14-3-3 protein family levels and associated receptor expression of estrogen and progesterone in Human Uterine Leiomyomas.
Leiomyoma
Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas.
Leiomyoma
Involvement of FKHR (FOXO1) transcription factor in human uterus leiomyoma growth.
Leiomyoma
Locostatin, a disrupter of Raf kinase inhibitor protein, inhibits extracellular matrix production, proliferation, and migration in human uterine leiomyoma and myometrial cells.
Leiomyoma
Reduced expression of 14-3-3 gamma in uterine leiomyoma as identified by proteomics.
Leiomyoma
The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development.
Leiomyosarcoma
Common genetic changes in leiomyosarcoma and gastrointestinal stromal tumour: implication for ataxia telangiectasia mutated involvement.
Leiomyosarcoma
Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice.
Leishmaniasis
6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis.
Leishmaniasis
An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3.
Leishmaniasis
Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.
Lentigo
Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.
Lentivirus Infections
Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.
LEOPARD Syndrome
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
LEOPARD Syndrome
[New findings in Noonan syndrome and Leopard syndrome: activating mutations in RAF-1 and SOS-1]
Leprosy
A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-? Release in Human Lymphoblasts.
Leprosy
A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy.
Leprosy
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
Leprosy
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.
Leprosy
Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China.
Leprosy
Crohn's Disease susceptibility genes are associated with leprosy in the Vietnamese population.
Leprosy
Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease1.
Leprosy
Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response.
Leprosy
Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus.
Leprosy
Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond.
Leprosy
Is there an antagonistic pleiotropic effect of a LRRK2 mutation on leprosy and Parkinson's disease?
Leprosy
Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
Leprosy
Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).
Leprosy
LRRK2 and autophagy: a common pathway for disease.
Leprosy
LRRK2 and human disease: a complicated question or a question of complexes?
Leprosy
LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.
Leprosy
LRRK2 and RIPK2 Variants in the NOD 2-Mediated Signaling Pathway Are Associated with Susceptibility to Mycobacterium leprae in Indian Populations.
Leprosy
LRRK2 and the Immune System.
Leprosy
LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.
Leprosy
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.
Leprosy
LRRK2 inhibition attenuates microglial inflammatory responses.
Leprosy
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Leprosy
Number and brightness analysis of LRRK2 oligomerization in live cells.
Leprosy
Parkinson's disease and immune system: is the culprit LRRKing in the periphery?
Leprosy
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Leprosy
Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson's disease.
Leprosy
Reply to Zhang et al.: The differential role of LRRK2 variants in nested leprosy phenotypes.
Leprosy
Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis.
Leprosy, Multibacillary
Genomewide association study of leprosy.
Leprosy, Paucibacillary
Genomewide association study of leprosy.
Leukemia
15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity.
Leukemia
2-Deoxyglucose inhibits chemotherapeutic drug-induced apoptosis in human monocytic leukemia U937 cells with inhibition of c-Jun N-terminal kinase 1/stress-activated protein kinase activation.
Leukemia
3D QSAR studies, molecular docking and ADMET evaluation, using thiazolidine derivatives as template to obtain new inhibitors of PIM1 kinase.
Leukemia
53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope.
Leukemia
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors.
Leukemia
A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ER?-positive breast cancer cells.
Leukemia
A murine sarcoma virus-associated protein kinase: interaction with actin and microtubular protein.
Leukemia
A Novel Aurora Kinase Inhibitor Attenuates Leukemic Cell Proliferation Induced by Mesenchymal Stem Cells.
Leukemia
A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.
Leukemia
A Phase I Trial and Pharmacokinetic Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib in Children with Refractory Solid Tumors or Refractory Leukemias.
Leukemia
A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation.
Leukemia
A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas.
Leukemia
A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis.
Leukemia
Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes.
Leukemia
Absence of the mutation of serine/threonine kinase genes AKT2 and MYLK2 in acute leukemias.
Leukemia
Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells.
Leukemia
Activation of Both Protein Kinase A (PKA) Type I and PKA Type II Isozymes Is Required for Retinoid-Induced Maturation of Acute Promyelocytic Leukemia Cells.
Leukemia
Activation of casein kinase II in ML-1 human myeloblastic leukemia cells requires IGF-1 and transferrin.
Leukemia
Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.
Leukemia
Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells.
Leukemia
Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis.
Leukemia
AMPK activators contribute to maintain naïve pluripotency in mouse embryonic stem cells.
Leukemia
An agonistic monoclonal antibody against DR5 induces ROS production, sustained JNK activation and Endo G release in Jurkat leukemia cells.
Leukemia
An open-label phase 2 study of glycogen synthase kinase-3 inhibitor LY2090314 in patients with acute leukemia.
Leukemia
Anti-ganglioside monoclonal antibody AA4 selectively inhibits IgE-induced signal transduction pathways in rat basophilic leukemia cells.
Leukemia
Antiapoptotic action of 1,25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c.
Leukemia
Apoptosis induced by genipin in human leukemia K562 cells: involvement of c-Jun N-terminal kinase in G(2)/M arrest.
Leukemia
Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway.
Leukemia
Association between Ataxia Telangiectasia Mutated gene polymorphisms and childhood leukemia in Taiwan.
Leukemia
ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks.
Leukemia
Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells.
Leukemia
Aurora kinases in childhood acute leukemia: the promise of Aurora B as therapeutic target.
Leukemia
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
Leukemia
Bacterial proteins as potential drugs in the treatment of leukemia.
Leukemia
Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells.
Leukemia
Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor.
Leukemia
Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer.
Leukemia
BRAF inhibition in hairy cell leukemia with low-dose vemurafenib.
Leukemia
Ca2+/calmodulin-dependent protein kinase II and cytosolic phospholipase A2 contribute to mitogenic signaling in myeloblastic leukemia U-937 cells.
Leukemia
Ca2+/calmodulin-dependent Protein Kinases in Leukemia Development.
Leukemia
CaMKII ?, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine.
Leukemia
Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls.
Leukemia
Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia.
Leukemia
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle.
Leukemia
Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy.
Leukemia
Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation.
Leukemia
Cellular signaling and epigenetic regulation of gene expression in leukemia.
Leukemia
CK2 inhibitors increase the sensitivity of HSV-1 to interferon-?.
Leukemia
Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation.
Leukemia
Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia.
Leukemia
Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.
Leukemia
Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation.
Leukemia
Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
Leukemia
Cyclic adenosine 3':5'-monophosphate-dependent and -independent protein kinase in acute myeloblastic leukemia.
Leukemia
Cysteinyl Leukotrienes Induce Monocyte Chemoattractant Protein-1 in Human Monocyte/Macrophages via Mitogen-Activated Protein Kinase and Nuclear Factor-kappaB Pathways.
Leukemia
Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.
Leukemia
Deguelin blocks cells survival signal pathways and induces apoptosis of HL-60 cells in vitro.
Leukemia
Derivation of Embryonic Stem Cell Lines From Parthenogenetically Developing Rat Blastocysts.
Leukemia
Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.
Leukemia
Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL.
Leukemia
EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferation.
Leukemia
EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer.
Leukemia
Effect of resveratrol on high glucose-induced stress in human leukemia K562 cells.
Leukemia
Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells.
Leukemia
Effects of endoplasmic reticulum stress on autophagy and apoptosis of human leukemia cells via inhibition of the PI3K/AKT/mTOR signaling pathway.
Leukemia
Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia.
Leukemia
Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.
Leukemia
Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia.
Leukemia
Expression of Proviral Integration Site for Moloney Murine Leukemia Virus 1 (Pim-1) Is Post-transcriptionally Regulated by Tristetraprolin in Cancer Cells.
Leukemia
Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1.
Leukemia
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia.
Leukemia
Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair.
Leukemia
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Leukemia
Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.
Leukemia
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation.
Leukemia
Glycogen synthase kinase-3 and alternative splicing.
Leukemia
Glycogen synthase kinase-3 and cancer: good cop, bad cop?
Leukemia
Glycogen synthase kinase-3 and leukemia: restoring the balance.
Leukemia
Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia.
Leukemia
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.
Leukemia
GSK-3 as a novel prognostic indicator in leukemia.
Leukemia
GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.
Leukemia
GSK-3: a multifaceted player in acute leukemias.
Leukemia
GSK-3beta, a therapeutic target for cardiomyocyte protection.
Leukemia
HA14-1 sensitizes TNF-alpha-induced apoptosis via inhibition of the NF-kappaB signaling pathway: involvement of reactive oxygen species and JNK.
Leukemia
Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.
Leukemia
High glucose promotes vascular smooth muscle cell proliferation by upregulating proto-oncogene serine/threonine-protein kinase Pim-1 expression.
Leukemia
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.
Leukemia
Human and Mouse Induced Pluripotent Stem Cells Are Differentially Reprogrammed in Response to Kinase Inhibitors.
Leukemia
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.
Leukemia
Identification and characterization of BRDT: A testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh.
Leukemia
IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia.
Leukemia
Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion.
Leukemia
Induction of apoptosis by cordycepin in ADA-inhibited TdT-positive leukemia cells.
Leukemia
Inhibition by dexamethasone of antigen-induced c-Jun N-terminal kinase activation in rat basophilic leukemia cells.
Leukemia
Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells.
Leukemia
Inhibition of Bcr serine kinase by tyrosine phosphorylation.
Leukemia
Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress.
Leukemia
Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells.
Leukemia
Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis.
Leukemia
Inhibition of Pim1 kinase prevents peanut allergy by enhancing Runx3 expression and suppressing T(H)2 and T(H)17 T-cell differentiation.
Leukemia
Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products--berberine, curcumin and picroliv.
Leukemia
Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation.
Leukemia
Inverse association between Bmi-1 and RKIP affecting clinical outcome of gastric cancer and revealing the potential molecular mechanisms underlying tumor metastasis and chemotherapy resistance.
Leukemia
Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells.
Leukemia
Involvement of c-Jun N-terminal Kinase in the Reversal of Multidrug Resistance Human Leukemia Cells in Hypoxia by 5-bromotetrandrine.
Leukemia
Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides.
Leukemia
JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells.
Leukemia
KAT8 Regulates Androgen Signaling in Prostate Cancer Cells.
Leukemia
Kinase-Addiction and Bi-Phasic Sensitivity-Resistance of Bcr-Abl-and Raf-1-Expressing Cells to Imatinib and Geldanamycin.
Leukemia
Knockdown of Pim-3 suppresses the tumorigenicity of glioblastoma by regulating cell cycle and apoptosis.
Leukemia
Leukemia inhibitory factor induces an antiapoptotic response in oligodendrocytes through Akt-phosphorylation and up-regulation of 14-3-3.
Leukemia
LiCl induces apoptosis via CHOP/NOXA/Mcl-1 axis in human choroidal melanoma cells.
Leukemia
Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent.
Leukemia
Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta.
Leukemia
Lithium, a classic drug in psychiatry, improves nilotinib-mediated antileukemic effects.
Leukemia
Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells.
Leukemia
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation.
Leukemia
Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin. Differential inhibition of protein kinase C, Ca2+/calmodulin-dependent protein kinase II and synaptosomal membrane Na,K-ATPase, and Na+ pump and differentiation of HL60 cells.
Leukemia
Methylglyoxal induces apoptosis in Jurkat leukemia T cells by activating c-Jun N-terminal kinase.
Leukemia
Microarray and proteomics analyses of human intestinal epithelial cells treated with the Aeromonas hydrophila cytotoxic enterotoxin.
Leukemia
MicroRNA-1246 by Targeting AXIN2 and GSK-3? Overcomes Drug Resistance and Induces Apoptosis in Chemo-resistant Leukemia Cells.
Leukemia
Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement.
Leukemia
Multifaceted roles of GSK-3 and Wnt/?-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.
Leukemia
Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription.
Leukemia
Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens.
Leukemia
New perspective on the dual functions of indirubins in cancer therapy and neuroprotection.
Leukemia
OCT4 supports extended LIF-independent self-renewal and maintenance of transcriptional and epigenetic networks in embryonic stem cells.
Leukemia
Overexpression of Serine Threonine Tyrosine Kinase 1/Novel Oncogene with Kinase Domain mRNA in Patients with Acute Leukemia.
Leukemia
Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.
Leukemia
Patterns and Significance of PIM Kinases in Urothelial Carcinoma.
Leukemia
Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia.
Leukemia
Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines.
Leukemia
Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma.
Leukemia
Pim-1 kinase as cancer drug target: An update.
Leukemia
PIM-1 kinase inhibitor SMI-4a exerts antitumor effects in chronic myeloid leukemia cells by enhancing the activity of glycogen synthase kinase 3?.
Leukemia
PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia.
Leukemia
PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.
Leukemia
Pim1 Kinase Inhibitors Exert Anti-Cancer Activity Against HER2-Positive Breast Cancer Cells Through Downregulation of HER2.
Leukemia
Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation.
Leukemia
PKR activity is required for acute leukemic cell maintenance and growth: a role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation.
Leukemia
PLK-1 Expression is Associated with Histopathological Response to Neoadjuvant Therapy of Hepatic Metastasis of Colorectal Carcinoma.
Leukemia
Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.
Leukemia
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Leukemia
Protein kinase A activation by retinoic acid in the nuclei of HL60 cells.
Leukemia
Protein kinase B/Akt regulation in diabetic kidney disease.
Leukemia
Protein kinase CK2 regulates AKT, NF-?B and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia.
Leukemia
Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias.
Leukemia
Protein signaling and regulation of gene transcription in leukemia: role of the Casein Kinase II-Ikaros axis.
Leukemia
Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.
Leukemia
Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt.
Leukemia
Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.
Leukemia
Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells.
Leukemia
Raf-1 independent stimulation of mitogen-activated protein kinase by leukemia inhibitory factor in 3T3-L1 cells.
Leukemia
Raf-1 is a necessary component of the mitogenic response of the human megakaryoblastic leukemia cell line MO7 to human stem cell factor, granulocyte-macrophage colony-stimulating factor, interleukin 3, and interleukin 9.
Leukemia
Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells.
Leukemia
Raf-1, a potential therapeutic target, mediates early steps in endometriosis lesion development by endometrial epithelial and stromal cells.
Leukemia
Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic myeloid leukemia K562 cells.
Leukemia
Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.
Leukemia
Relation of protein kinase A and protein kinase C to signaling pathways of hematopoietic factors in leukemia cell lines.
Leukemia
RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F.
Leukemia
RKTG overexpression inhibits proliferation and induces apoptosis of human leukemia cells via suppression of the ERK and PI3K/AKT signaling pathways.
Leukemia
Role of PIM2 in allergic asthma.
Leukemia
Roles of Pim-3, a novel survival kinase, in tumorigenesis.
Leukemia
Section 1. Antibiotics and Chemotherapeutics Apigenin induces DNA damage through the PKC?-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.
Leukemia
Selective treatment of mixed-lineage leukemia leukemic stem cells through targeting glycogen synthase kinase 3 and the canonical Wnt/?-catenin pathway.
Leukemia
Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia.
Leukemia
Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1.
Leukemia
Sp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7.
Leukemia
Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression.
Leukemia
Src family tyrosine kinase p53/56lyn, a serine kinase and Fc epsilon RI associate with alpha-galactosyl derivatives of ganglioside GD1b in rat basophilic leukemia RBL-2H3 cells.
Leukemia
Stable generation of serum- and feeder-free embryonic stem cell-derived mice with full germline-competency by using a GSK3 specific inhibitor.
Leukemia
STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells.
Leukemia
Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation.
Leukemia
Structure of a Moloney murine leukemia virus-virus-like 30 recombinant: implications for transduction of the c-Ha-ras proto-oncogene.
Leukemia
Studies of perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts.
Leukemia
Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal.
Leukemia
Surface immunoglobulin-mediated signal transduction involves rapid phosphorylation and activation of the protooncogene product Raf-1 in human B-cells.
Leukemia
Switching leukemia cell phenotype between life and death.
Leukemia
Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51.
Leukemia
Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.
Leukemia
Targeting heat shock protein 90 with non-quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma.
Leukemia
Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.
Leukemia
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Leukemia
Targeting Raf-1 gene expression by a DNA enzyme inhibits juvenile myelomonocytic leukemia cell growth.
Leukemia
Tetrahydroxyquinone induces apoptosis of leukemia cells through diminished survival signaling.
Leukemia
The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling.
Leukemia
The combination of UCN-01 and ATRA triggers differentiation in ATRA resistant acute promyelocytic leukemia cell lines via RAF-1 independent activation of MEK/ERK.
Leukemia
The Current State of Naïve Human Pluripotency.
Leukemia
The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells.
Leukemia
The novel anti-adipogenic effect and mechanisms of action of SGI-1776, a Pim-specific inhibitor, in 3T3-L1 adipocytes.
Leukemia
The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression.
Leukemia
The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 kinase via pyrimidine depletion.
Leukemia
The role of autophagy in targeted therapy for acute myeloid leukemia.
Leukemia
The role of exosomes and MYC in therapy resistance of acute myeloid leukemia: Challenges and opportunities.
Leukemia
The serine-threonine kinase PIM3 is an aldosterone-regulated protein in the distal nephron.
Leukemia
The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage.
Leukemia
Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.
Leukemia
Treatment of U937 cells with bufalin induces the translocation of casein kinase 2 and modulates the activity of topoisomerase II prior to the induction of apoptosis.
Leukemia
Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation.
Leukemia
Up-regulation of HO-1 promotes resistance of B-cell acute lymphocytic leukemia cells to HDAC4/5 inhibitor LMK-235 via the Smad7 pathway.
Leukemia
Update on developmental therapeutics for acute lymphoblastic leukemia.
Leukemia
Using insights into Pim1 structure to design new anticancer drugs.
Leukemia
Wei Zhang, Bao-an Chen, Jun-fei Jin, You-ji He, and Yi-qi Niu, Involvement of c-Jun N-terminal kinase in reversal of multidrug resistance of human leukemia cells in hypoxia by 5-bromotetrandrine. November 2013;54(11):2506-2516. http://dx.doi.org/10.3109/10428194.2013.776681.
Leukemia
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.
Leukemia
[Correlation of expression of PTEN with AKT phosphorylation level in leukemia cells].
Leukemia
[Detecting phospho-signaling protein of bone marrow leukemia cells by phospho-signaling flow cytometry].
Leukemia
[Effect of SHIP-1 on Invasion, Migration and PI3K-AKT Signaling Pathway of Leukemic Cells].
Leukemia
[Effects of mitoxantrone on the activity of human protein kinase CK2 holoenzyme]
Leukemia
[Expression and kinase activity of B-Raf and Raf-1 in leukemia cell lines]
Leukemia
[Expression of DNA-dependent protein kinase catalylic subunit in adult acute leukemia and its significance].
Leukemia
[Expression of ILK and PKB/Akt in Acute Leukemia and Its Significance].
Leukemia
[Expression of PTEN mRNA, hTERT and DNA-PKcs in bone marrow cells of children with acute leukemia]
Leukemia
[The mechanism for SHIP gene to induce the apoptosis of human leukemia cell line K562.]
Leukemia L1210
Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.
Leukemia L1210
Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.
Leukemia, B-Cell
Regulation of brain cell death and survival after cardiopulmonary bypass.
Leukemia, Erythroblastic, Acute
Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-beta isoform.
Leukemia, Erythroblastic, Acute
Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases.
Leukemia, Erythroblastic, Acute
Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents.
Leukemia, Erythroblastic, Acute
Effect of protein kinase A on inositide metabolism and rap 1 G-protein in human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Hexamethylene bisacetamide-induced differentiation of Friend virus-transformed murine erythroleukemia cells is associated with parallel changes in casein kinase II and guanine nucleotide exchange factor activities.
Leukemia, Erythroblastic, Acute
Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia.
Leukemia, Erythroblastic, Acute
Phosphorylation of ornithine decarboxylase in intact erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Regulation of the erythroid transcription factor NF-E2 by cyclic adenosine monophosphate-dependent protein kinase.
Leukemia, Hairy Cell
BRAF inhibition in hairy cell leukemia with low-dose vemurafenib.
Leukemia, Hairy Cell
Surface immunoglobulin-mediated signal transduction involves rapid phosphorylation and activation of the protooncogene product Raf-1 in human B-cells.
Leukemia, Large Granular Lymphocytic
Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway.
Leukemia, Lymphocytic, Chronic, B-Cell
Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Clonal evolution of chronic lymphocytic leukemia to Langerhans cell histiocytosis: a case report.
Leukemia, Lymphocytic, Chronic, B-Cell
CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway.
Leukemia, Lymphocytic, Chronic, B-Cell
DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Genetic counseling for DAPK1 mutation in a chronic lymphocytic leukemia family.
Leukemia, Lymphocytic, Chronic, B-Cell
Germline allele-specific expression of DAPK1 in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma.
Leukemia, Lymphocytic, Chronic, B-Cell
Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Inhibition of the Raf-1 kinase inhibitory protein (RKIP) by locostatin induces cell death and reduces the CXCR4-mediated migration of chronic lymphocytic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
MicroRNA-155 regulates casein kinase 1 gamma 2: a potential pathogenetic role in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.
Leukemia, Lymphocytic, Chronic, B-Cell
Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth.
Leukemia, Lymphocytic, Chronic, B-Cell
Quantitative analyses of DAPK1 methylation in AML and MDS.
Leukemia, Lymphocytic, Chronic, B-Cell
Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.
Leukemia, Lymphocytic, Chronic, B-Cell
Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants.
Leukemia, Lymphocytic, Chronic, B-Cell
The Aurora A and B kinases are upregulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets.
Leukemia, Lymphocytic, Chronic, B-Cell
The p53 pathway induction is not primarily dependent on Ataxia Telangiectasia Mutated (ATM) gene activity after fludarabine treatment in chronic lymphocytic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration.
Leukemia, Lymphocytic, Chronic, B-Cell
USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status.
Leukemia, Lymphocytic, Chronic, B-Cell
Vincristine activates c-Jun N-terminal kinase in chronic lymphocytic leukemia in vivo.
Leukemia, Lymphoid
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells.
Leukemia, Megakaryoblastic, Acute
[SP600125-induced polyploidization of megakaryocytic leukemia cell lines by ribosomal protein S6 kinase 1 depends on the degree of cell differentiation].
Leukemia, Monocytic, Acute
Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
14-3-3 Binding and Sumoylation Concur to the Down-Modulation of ?-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
14-3-3 LIGAND PREVENTS NUCLEAR IMPORT OF C-ABL PROTEIN IN CHRONIC MYELOID LEUKEMIA.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A NEW NON-PEPTIDIC INHIBITOR OF THE 14-3-3 DOCKING SITE INDUCES APOPTOTIC CELL DEATH IN CHRONIC MYELOID LEUKEMIA SENSITIVE OR RESISTANT TO IMATINIB.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A novel e8a2 BCR-ABL1 fusion with insertion of MAST2 exon 2 in a four-way translocation t (1;17;9;22) (p35;q24;q44;q11) in a patient with chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Aberrant methylation of the death-associated protein kinase 1 (DAPK1) CpG island in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Activation of c-Jun N-terminal kinase mediates tanshinone IIA-induced apoptosis in KBM-5 chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Anticancer therapeutics: "Addictive" targets, multi-targeted drugs, new drug combinations.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor?sensitive and ?resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Multiplexed Quantitative MALDI MS Approach for Assessing Activity and Inhibition of Protein Kinases Based on Postenrichment Dephosphorylation of Phosphopeptides by Metal-Organic Framework-Templated Porous CeO2.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein kinases in human leukemic cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic myeloid leukemia K562 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Reduction of Raf kinase inhibitor protein expression by Bcr-Abl contributes to chronic myelogenous leukemia proliferation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Significance of ATM Gene Polymorphisms in Chronic Myeloid Leukemia - a Case Control Study from India.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukemia and significantly increases the efficacy of nilotinib.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Effect of Meisoindigo on Wnt signal pathway in K562 and HL-60 cells]
Leukemia, Myeloid
A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.
Leukemia, Myeloid
Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells.
Leukemia, Myeloid
Activation of the pp90rsk and mitogen-activated serine/threonine protein kinases by ionizing radiation.
Leukemia, Myeloid
Ca2+/calmodulin-dependent Protein Kinases in Leukemia Development.
Leukemia, Myeloid
CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells.
Leukemia, Myeloid
Chronic Deletion and Acute Knockdown of Parkin have Differential Responses to Acetaminophen-Induced Mitophagy and Liver Injury in Mice.
Leukemia, Myeloid
Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT.
Leukemia, Myeloid
Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells.
Leukemia, Myeloid
Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1.
Leukemia, Myeloid
Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.
Leukemia, Myeloid
Inhibition of CHK1 kinase by Gö6976 converts 8-chloro-adenosine-induced G2/M arrest into S arrest in human myelocytic leukemia K562 cells.
Leukemia, Myeloid
Kaempferia parviflora extract inhibits TNF-?-induced release of MCP-1 in ovarian cancer cells through the suppression of NF-?B signaling.
Leukemia, Myeloid
MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.
Leukemia, Myeloid
Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3.
Leukemia, Myeloid
Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia.
Leukemia, Myeloid
Polo-like kinase-1 as novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of siRNA and the Polo-like kinase-1 targeting drug BI 2536.
Leukemia, Myeloid
Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells.
Leukemia, Myeloid
Raf-1 signaling is required for the later stages of 1,25-dihydroxyvitamin D(3)-induced differentiation of HL60 cells but is not mediated by the MEK/ERK module.
Leukemia, Myeloid
Resistance to phorbol ester-induced differentiation of a U-937 myeloid leukemia cell variant with a signaling defect upstream to Raf-1 kinase.
Leukemia, Myeloid
Retraction notice to "The retinoic acid receptor/CaMKII interaction: Pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells" [Blood Cells Mol. Dis. 39 (2007) 307-315].
Leukemia, Myeloid
RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines.
Leukemia, Myeloid
Subcellular localization of full-length human myeloid leukemia factor 1 (MLF1) is independent of 14-3-3 proteins.
Leukemia, Myeloid
The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.
Leukemia, Myeloid
The Requirement for and Changing Composition of the Activating Protein-1 Transcription Factor during Differentiation of Human Leukemia HL60 Cells Induced by 1,25-Dihydroxyvitamin D3.
Leukemia, Myeloid
The retinoic acid receptor/CaMKII interaction: Pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells.
Leukemia, Myeloid, Acute
A Case of Therapy-Related Acute Myeloid Leukemia in a Patient With Heterozygous Mutations in the Ataxia Telangiectasia Mutated Gene.
Leukemia, Myeloid, Acute
A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.
Leukemia, Myeloid, Acute
A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity.
Leukemia, Myeloid, Acute
A-kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C-X-C motif) ligand 1/chemokine (C-X-C motif) ligand 2 in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes.
Leukemia, Myeloid, Acute
Activation of the Intracellular Pattern-Recognition Receptor NOD2 Promotes Acute Myeloid Leukemia (AML) Cell Apoptosis and Provides a Survival Advantage in an Animal Model of AML.
Leukemia, Myeloid, Acute
All-trans retinoic acid exerts selective anti-FLT3-ITD acute myeloid leukemia efficacy through downregulating Chk1 kinase.
Leukemia, Myeloid, Acute
An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes.
Leukemia, Myeloid, Acute
Analysis of Aurora kinase A expression in CD34(+) blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia.
Leukemia, Myeloid, Acute
Aurora A and NF-?B Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.
Leukemia, Myeloid, Acute
Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes.
Leukemia, Myeloid, Acute
Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells.
Leukemia, Myeloid, Acute
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
Leukemia, Myeloid, Acute
BAY-43-9006 Bayer/Onyx.
Leukemia, Myeloid, Acute
c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Casein kinase 1? inhibits p53 downstream of MDM2?mediated autophagy and apoptosis in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Combined inhibition of the phosphoinosityl-3-kinase (PI3Kinase) P110d subunit and mitogen-extracellular activated protein kinase (MEKinase) shows synergistic cytotoxicity against human acute myeloid leukemia progenitors.
Leukemia, Myeloid, Acute
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation.
Leukemia, Myeloid, Acute
Cyclic adenosine 3':5'-monophosphate-dependent and -independent protein kinase in acute myeloblastic leukemia.
Leukemia, Myeloid, Acute
Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia.
Leukemia, Myeloid, Acute
DAP-kinase CpG island methylation in acute myeloid leukemia: methodology versus biology?
Leukemia, Myeloid, Acute
Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL.
Leukemia, Myeloid, Acute
Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro.
Leukemia, Myeloid, Acute
Erlotinib antagonizes constitutive activation of SRC family kinases and mTOR in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Expression of PIM-2 and NF-?B genes is increased in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and is associated with complete remission rate and overall survival.
Leukemia, Myeloid, Acute
Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1.
Leukemia, Myeloid, Acute
FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1.
Leukemia, Myeloid, Acute
Fms-like tyrosine kinase 3-internal tandem duplications epigenetically activates checkpoint kinase 1 in acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
Forskolin Sensitizes Human Acute Myeloid Leukemia Cells to H3K27me2/3 Demethylases GSKJ4 Inhibitor via Protein Kinase A.
Leukemia, Myeloid, Acute
Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients.
Leukemia, Myeloid, Acute
Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Glycogen Synthase Kinase-3 and phospholipase C-beta signalling: Roles and possible interactions in myelodysplastic syndromes and acute myeloid leukemia.
Leukemia, Myeloid, Acute
GSK-3 inhibition sensitizes acute myeloid leukemia cells to 1,25D-mediated differentiation.
Leukemia, Myeloid, Acute
GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.
Leukemia, Myeloid, Acute
High expression of long intergenic non-coding RNA LINC00662 contributes to malignant growth of acute myeloid leukemia cells by upregulating ROCK1 via sponging microRNA-340-5p.
Leukemia, Myeloid, Acute
Identification of A-kinase interacting protein 1 as a potential biomarker for risk and prognosis of acute myeloid leukemia.
Leukemia, Myeloid, Acute
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3?.
Leukemia, Myeloid, Acute
Inhibition of Casein Kinase 1 Alpha in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity.
Leukemia, Myeloid, Acute
Inhibition of raf kinase in the treatment of acute myeloid leukemia.
Leukemia, Myeloid, Acute
Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis.
Leukemia, Myeloid, Acute
Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations.
Leukemia, Myeloid, Acute
MiR-592 functions as a tumor suppressor in acute myeloid leukemia by targeting ROCK1 and predicts patients' prognosis.
Leukemia, Myeloid, Acute
Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription.
Leukemia, Myeloid, Acute
Novel B55?-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest.
Leukemia, Myeloid, Acute
Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia.
Leukemia, Myeloid, Acute
Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies.
Leukemia, Myeloid, Acute
Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
Phase I Trial of Lithium and Tretinoin for Treatment of Relapsed and Refractory Non-promyelocytic Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells.
Leukemia, Myeloid, Acute
Protein kinase CK2 regulates AKT, NF-?B and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Protein kinases in human leukemic cells.
Leukemia, Myeloid, Acute
Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation.
Leukemia, Myeloid, Acute
Selective inhibition of Aurora A and B kinases effectively induces cell cycle arrest in t(8;21) acute myeloid leukemia.
Leukemia, Myeloid, Acute
Targeting of Protein Kinase CK2 in Acute Myeloid Leukemia Cells Using the Clinical-Grade Synthetic-Peptide CIGB-300.
Leukemia, Myeloid, Acute
Targeting on glycosylation of mutant FLT3 in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Targeting the Akt, GSK-3, Bcl-2 axis in acute myeloid leukemia.
Leukemia, Myeloid, Acute
The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.
Leukemia, Myeloid, Acute
The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells.
Leukemia, Myeloid, Acute
The role of autophagy in targeted therapy for acute myeloid leukemia.
Leukemia, Myeloid, Acute
[Correlation of NK cell RIPK1 with Prognosis of Acute Myeloid Leukemia Patients with FLT3-ITD Mutation].
Leukemia, Myeloid, Acute
[The correlation study of PTEN gene expression and Akt phosphorylation in myelodysplastic syndrome]
Leukemia, Myeloid, Acute
[Treatment outcome of multidrug resistance related mRNA expression and c-jun-N-terminal kinase activity in patients with acute myeloid leukemia]
Leukemia, Myelomonocytic, Juvenile
Targeting Raf-1 gene expression by a DNA enzyme inhibits juvenile myelomonocytic leukemia cell growth.
Leukemia, Prolymphocytic, T-Cell
T-cell prolymphocytic leukemia with der(11)t(1;11)(q21;q23) and ATM deficiency.
Leukemia, Promyelocytic, Acute
Activation of Both Protein Kinase A (PKA) Type I and PKA Type II Isozymes Is Required for Retinoid-Induced Maturation of Acute Promyelocytic Leukemia Cells.
Leukemia, Promyelocytic, Acute
Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells.
Leukemia, Promyelocytic, Acute
Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL.
Leukemia, Promyelocytic, Acute
Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells.
Leukemia, Promyelocytic, Acute
JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells.
Leukemia, Promyelocytic, Acute
Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent.
Leukemia, Promyelocytic, Acute
Sp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7.
Leukemia, Promyelocytic, Acute
The combination of UCN-01 and ATRA triggers differentiation in ATRA resistant acute promyelocytic leukemia cell lines via RAF-1 independent activation of MEK/ERK.
Leukemia, Promyelocytic, Acute
The role of autophagy in targeted therapy for acute myeloid leukemia.
Leukemia, T-Cell
Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV-1-infected T-cells in vitro.
Leukemia, T-Cell
Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.
Leukemia, T-Cell
Evidence that protein kinase A activity is required for the basal and tax-stimulated transcriptional activity of human T-cell leukemia virus type-I long terminal repeat.
Leukemia, T-Cell
Protein kinase C theta cooperates with Vav1 to induce JNK activity in T-cells.
Leukemia, T-Cell
Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia.
Leukemia, T-Cell
Role of protein kinase A in tax transactivation of the human T-cell leukemia virus type I long terminal repeat.
Leukemia, T-Cell
Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins.
Leukemia, T-Cell
T-cell prolymphocytic leukemia with der(11)t(1;11)(q21;q23) and ATM deficiency.
Leukemia-Lymphoma, Adult T-Cell
Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV-1-infected T-cells in vitro.
Leukemia-Lymphoma, Adult T-Cell
Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma.
Leukocytosis
Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis.
Leukoencephalopathies
Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism.
Leukoencephalopathies
Increased 14-3-3 immunoreactivity in glial elements in patients with multiple sclerosis.
Leukoencephalopathies
Reversible posterior leukoencephalopathy syndrome induced by RAF kinase inhibitor BAY 43-9006.
Leukoencephalopathies
Yield and Clinical Utility of Next-Generation Sequencing in Selected Patients With Lung Adenocarcinoma.
Leukoencephalopathy, Progressive Multifocal
Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism.
Leukoencephalopathy, Progressive Multifocal
Increased 14-3-3 immunoreactivity in glial elements in patients with multiple sclerosis.
Leukoplakia, Oral
Expression of DNA doublestrand repair proteins in oral leukoplakia and the risk of malignant transformation.
Leukoplakia, Oral
Immunohistochemical Analysis of the Activation Status of the Akt/mTOR/pS6 Signaling Pathway in Oral Lichen Planus.
Leukoplakia, Oral
TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma.
Lewy Body Disease
14-3-3 protein sigma isoform co-localizes with phosphorylated ?-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease.
Lewy Body Disease
14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains.
Lewy Body Disease
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
Lewy Body Disease
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Lewy Body Disease
Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model.
Lewy Body Disease
Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.
Lewy Body Disease
Lrrk2 and Lewy body disease.
Lewy Body Disease
LRRK2 and neurodegeneration.
Lewy Body Disease
Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease.
Lewy Body Disease
T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model.
Lewy Body Disease
The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.
Lewy Body Disease
[Clinical molecular genetics for PARK8 (LRRK2)]
Li-Fraumeni Syndrome
Aberrations of the CHK2 gene are rare in pediatric solid tumors.
Li-Fraumeni Syndrome
Genetic testing by cancer site: stomach.
Li-Fraumeni Syndrome
Hereditary breast cancer: the era of new susceptibility genes.
Li-Fraumeni Syndrome
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Li-Fraumeni Syndrome
Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA.
Limbic Encephalitis
BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis.
Lipid Metabolism Disorders
Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.
Lipid Metabolism Disorders
Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt.
Lipodystrophy
Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.
Liposarcoma, Myxoid
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
Lissencephaly
Characterization of a Drosophila melanogaster orthologue of muskelin.
Lissencephaly
De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features.
Lissencephaly
Lissencephaly and the molecular basis of neuronal migration.
Lissencephaly
Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.
Liver Cirrhosis
Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution.
Liver Cirrhosis
Clinical significance of serum 14-3-3 beta in patients with hepatocellular carcinoma.
Liver Cirrhosis
Development of liver fibrosis during aging: effects of caloric restriction.
Liver Cirrhosis
Increased protein kinase A regulatory subunit content and cGMP binding in erythrocyte membranes in liver cirrhosis.
Liver Cirrhosis
Knockdown of HIPK2 attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-?1.
Liver Cirrhosis
Modulation of TGF-beta signaling during progression of chronic liver diseases.
Liver Cirrhosis
p70 ribosomal protein S6 kinase is a checkpoint of human hepatic stellate cell activation and liver fibrosis in mice.
Liver Cirrhosis
P7C3-A20, a neuroprotective agent, alleviates fatty liver by inducing FGF21/FGF1 in a LKB1/AMPK/CRTC2-dependent manner and shaping gut microbiota.
Liver Cirrhosis
RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1-TLR4-NF-?B pathway in macrophages.
Liver Cirrhosis
Survivin overexpression in HCC and liver cirrhosis differentially correlates with p-STAT3 and E-cadherin.
Liver Cirrhosis
Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
Liver Cirrhosis
Yu Gan Long Ameliorates Hepatic Fibrosis by Inhibiting PI3K/AKT, Ras/ERK and JAK1/STAT3 Signaling Pathways in CCl4-induced Liver Fibrosis Rats.
Liver Cirrhosis
[Expressions of Raf-1 kinase, phosphorylated mitogen extracellular kinase 1, and phosphorylated extracellular signal-regulated protein kinase 1/2 in hepatocellular carcinoma and their relationship with prognosis]
Liver Cirrhosis, Biliary
Emerging views of mitophagy in immunity and autoimmune diseases.
Liver Diseases
Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease.
Liver Diseases
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Liver Diseases
BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of ?-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis.
Liver Diseases
c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps.
Liver Diseases
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice.
Liver Diseases
Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.
Liver Diseases
DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy.
Liver Diseases
Effects of different therapeutic methods and typical recipes of Chinese medicine on activation of c-Jun N-terminal Kinase in Kupffer cells of rats with fatty liver disease.
Liver Diseases
Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4.
Liver Diseases
Fibrolamellar carcinoma: A histologically unique tumor with unique molecular findings.
Liver Diseases
Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
Liver Diseases
GSK-3 in liver diseases: Friend or foe?
Liver Diseases
Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase.
Liver Diseases
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver.
Liver Diseases
JNK signaling pathway in metabolic disorders: An emerging therapeutic target.
Liver Diseases
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liver Diseases
LRRK2 Regulates CPT1A to Promote ?-Oxidation in HepG2 Cells.
Liver Diseases
Modulation of TGF-beta signaling during progression of chronic liver diseases.
Liver Diseases
Regulation of organic anion transport in the liver.
Liver Diseases
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.
Liver Diseases
The ménage à trois of autophagy, lipid droplets and liver disease.
Liver Diseases
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Liver Diseases
[Activation of Kupffer cell and related signal pathway proteins in the liver of high fat and high fructose diet induced NAFLD mice].
Liver Diseases
[Role of JNK signal transduction pathway in nonalcoholic fatty liver disease]
Liver Failure
Mitogen-activated Protein Kinase Phosphatase (Mkp)-1 Protects Mice against Acetaminophen-induced Hepatic Injury.
Liver Failure, Acute
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Liver Failure, Acute
Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y2 receptor-mediated JNK activation.
Liver Failure, Acute
Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury.
Liver Neoplasms
15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
Liver Neoplasms
A novel AKT inhibitor, AZD5363, inhibits phosphorylation of AKT downstream molecules, and activates phosphorylation of mTOR and SMG-1 dependent on the liver cancer cell type.
Liver Neoplasms
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Liver Neoplasms
Anticancer Effect of ERM210 on Liver Cancer Cells Through ROS/Mitochondria-dependent Apoptosis Signaling Pathways.
Liver Neoplasms
Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II.
Liver Neoplasms
c-Myc is a major determinant for antitumor activity of Aurora A kinase inhibitor MLN8237 in thyroid cancer.
Liver Neoplasms
Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
Liver Neoplasms
Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling.
Liver Neoplasms
Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.
Liver Neoplasms
Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay.
Liver Neoplasms
DNA-PKcs: A promising therapeutic target in human hepatocellular carcinoma?
Liver Neoplasms
Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase.
Liver Neoplasms
Evaluation of pro-apoptotic potential of taxifolin against liver cancer.
Liver Neoplasms
Genetic ablation of TAZ induces HepG2 liver cancer cell apoptosis through activating the CaMKII/MIEF1 signaling pathway.
Liver Neoplasms
Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines.
Liver Neoplasms
HIF-2? phosphorylation by CK1? promotes erythropoietin secretion in liver cancer cells under hypoxia.
Liver Neoplasms
High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer.
Liver Neoplasms
Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma.
Liver Neoplasms
Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma.
Liver Neoplasms
Impaired phosphorylation and ubiquitination by P70 S6 kinase (P70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promotes Tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer.
Liver Neoplasms
MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.
Liver Neoplasms
MicroRNA-101 modulates cisplatin chemoresistance in liver cancer cells via the DNA-PKcs signaling pathway.
Liver Neoplasms
mTOR and P70 S6 kinase expression in primary liver neoplasms.
Liver Neoplasms
Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer.
Liver Neoplasms
New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.
Liver Neoplasms
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Liver Neoplasms
Phenformin and ataxia-telangiectasia mutated inhibitors synergistically co-suppress liver cancer cell growth by damaging mitochondria.
Liver Neoplasms
Protein kinase N1 promotes proliferation and invasion of liver cancer.
Liver Neoplasms
Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events.
Liver Neoplasms
Rapamycin blocks hepatoblastoma growth in vitro and in vivo implicating new treatment options in high-risk patients.
Liver Neoplasms
Ras signaling and therapies.
Liver Neoplasms
Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic myeloid leukemia K562 cells.
Liver Neoplasms
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.
Liver Neoplasms
Serine/Threonine Kinase Pim-2 Promotes Liver Tumorigenesis Induction Through Mediating Survival and Preventing Apoptosis of Liver Cell.
Liver Neoplasms
Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling.
Liver Neoplasms
Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells.
Liver Neoplasms
Targeting the Ca2+/Calmodulin-dependent protein kinase II by Tetrandrine in human liver cancer cells.
Liver Neoplasms
The expressions of Hedgehog and PI3K-AKT pathway components correlate with invasion and metastasis in hepatocellular carcinoma.
Liver Neoplasms
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2.
Liver Neoplasms
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
Liver Neoplasms
Upregulation of Stress-Induced Protein Kinase CK1 Delta is associated with a Poor Prognosis for patients with Hepatocellular Carcinoma.
Liver Neoplasms
[Expression of DNA-PK in hepato- and cholangio-neoplasms and its significance.]
Liver Neoplasms
[Genes and molecular mechanisms affecting the correlation between liver cancer and diabetes mellitus].
Liver Neoplasms
[The function of Aurora A and its role in the development of liver cancer].
Liver Neoplasms, Experimental
Characterization of highly phosphorylated subcomponents of rat thymus H1 histone.
Liver Neoplasms, Experimental
Maturation-promoting factor and the regulation of the cell cycle.
Liver Neoplasms, Experimental
Purification and characterization of growth-associated H1 histone kinase from Novikoff hepatoma cells.
Liver Neoplasms, Experimental
Regulation of polyamine-responsive protein kinase by certain highly specific polyamines and charged carbohydrates.
Liver Neoplasms, Experimental
Topoisomerase I phosphorylation in vitro and in rapidly growing Novikoff hepatoma cells.
Loeys-Dietz Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Long QT Syndrome
Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region.
Lordosis
In the ventral tegmental area, progestins' membrane-mediated actions for lordosis of hamsters and rats involve protein kinase A.
Lordosis
Lordosis facilitation by leptin in ovariectomized, estrogen-primed rats requires simultaneous or sequential activation of several protein kinase pathways.
Lung Diseases
Glycogen synthase kinase-3 (GSK-3) regulates TGF-?(1) -induced differentiation of pulmonary fibroblasts.
Lung Diseases
Interactive Roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases.
Lung Diseases
Oxidant stress promotes disease by activating CaMKII.
Lung Diseases
Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.
Lung Diseases
[Correlation of P27 expression and localization to phosphorylated AKT in non-small cell lung cancer]
Lung Diseases, Interstitial
Strain background determines lymphoma incidence in atm knockout mice.
Lung Diseases, Obstructive
A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.
Lung Diseases, Obstructive
Distinct PKA and Epac compartmentalization in airway function and plasticity.
Lung Injury
3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
Lung Injury
3-O-trans-caffeoyloleanolic acid improves acute lung injury via anti-inflammation and antioxidative stress-involved PI3K/AKT pathway.
Lung Injury
?-Opioid receptor signalling via PI3K/Akt pathway ameliorates lipopolysaccharide-induced acute respiratory distress syndrome.
Lung Injury
Bleomycin-induced nuclear factor-kappaB activation in human bronchial epithelial cells involves the phosphorylation of glycogen synthase kinase 3beta.
Lung Injury
Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1? signaling pathway.
Lung Injury
Effects of c-Jun N-Terminal Kinase Signaling Pathway on Severe Acute Pancreatitis-Associated Lung Injury.
Lung Injury
Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1?-related lung injury.
Lung Injury
Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 ? in neonatal rats.
Lung Injury
Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice.
Lung Injury
Glycogen synthase kinase-3beta inhibition attenuates the development of bleomycin-induced lung injury.
Lung Injury
Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice.
Lung Injury
Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats.
Lung Injury
Mechanism of Yifei Decoction Combined with MitoQ on Inhibition of TGF?1/NOX4 and PDGF/ROCK Signal Pathway in Idiopathic Pulmonary Fibrosis.
Lung Injury
Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury.
Lung Injury
Non?canonical Wnt signaling contributes to ventilator?induced lung injury through upregulation of WISP1 expression.
Lung Injury
Role of GADD45a in Akt Phosphorylation and Ubiquitination Following Mechanical Stress-Induced Vascular Injury.
Lung Injury
Role of PI3K/Akt/NF-?B and GSK-3? pathways in the rat model of cardiopulmonary bypass-related lung injury.
Lung Injury
Stress-activated protein kinase inhibition to ameliorate lung ischemia reperfusion injury.
Lung Injury
Tanshinone IIA suppresses lung injury and apoptosis, and modulates protein kinase B and extracellular signal-regulated protein kinase pathways in rats challenged with seawater exposure.
Lung Injury
[Dexamethasone on alleviating lung ischemia/reperfusion injury in rats by regulating PI3K/AKT pathway].
Lung Injury
[Effects of phosphorylated mitogen-activated protein kinases on phosgene inhalation-induced lung injury in rats and its relationship with matrix metalloproteinase].
Lung Injury
[Total flavonoids from astragalus complanatus attenuates lung injury following paraquat poisoning in rats through inhibiting excessive endoplasmic reticulum stress and c-Jun N-terminal kinase pathway].
Lung Neoplasms
?-Catulin drives metastasis by activating ILK and driving an ?v?3 integrin signaling axis.
Lung Neoplasms
A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells.
Lung Neoplasms
A detailed smoking history and determination of MYC status predict response to checkpoint inhibitors in advanced non-small cell lung cancer.
Lung Neoplasms
A meta-analysis and bioinformatics exploration of the diagnostic value and molecular mechanism of miR-193a-5p in lung cancer.
Lung Neoplasms
A meta-analysis of the relationship between ataxia-telangiectasia mutated gene polymorphisms and lung cancer susceptibility.
Lung Neoplasms
A novel synthetic analog of Militarin, MA-1 induces mitochondrial dependent apoptosis by ROS generation in human lung cancer cells.
Lung Neoplasms
A Phase II Trial of Prexasertib (LY2606368) in Patients With Extensive-Stage Small-Cell Lung Cancer.
Lung Neoplasms
A randomized, phase 2 evaluation of the CHK1 inhibitor, LY2603618, administered in combination with pemetrexed and cisplatin in patients with advanced nonsquamous non-small cell lung cancer.
Lung Neoplasms
Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens.
Lung Neoplasms
Actionable driver DNA variants and fusion genes can be detected in archived cytological specimens with the Oncomine Dx Target Test Multi-CDx system in lung cancer.
Lung Neoplasms
Activated Raf-1 causes growth arrest in human small cell lung cancer cells.
Lung Neoplasms
Activation of Aurora A kinase increases YAP stability via blockage of autophagy.
Lung Neoplasms
Activation of protein kinase B (PKB/Akt) and risk of lung cancer among rural women in India who cook with biomass fuel.
Lung Neoplasms
Adequacy of small biopsy and cytology specimens for comprehensive genomic profiling of patients with non-small-cell lung cancer to determine eligibility for immune checkpoint inhibitor and targeted therapy.
Lung Neoplasms
Advances in anti-BRAF therapies for lung cancer.
Lung Neoplasms
Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.
Lung Neoplasms
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer.
Lung Neoplasms
AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.
Lung Neoplasms
AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression.
Lung Neoplasms
Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway.
Lung Neoplasms
An approach to studying lung cancer-related proteins in human blood.
Lung Neoplasms
An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.
Lung Neoplasms
Anti-apoptotic brain and reproductive organ-expressed proteins enhance cisplatin resistance in lung cancer cells via the protein kinase B signaling pathway.
Lung Neoplasms
Anticancer activity of the Aurora A kinase inhibitor MK-5108 in non-small-cell lung cancer (NSCLC) in vitro as monotherapy and in combination with chemotherapies.
Lung Neoplasms
Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer.
Lung Neoplasms
ANXA1-GSK3? interaction and its involvement in NSCLC metastasis.
Lung Neoplasms
Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.
Lung Neoplasms
Assays for raf-1 kinase phosphorylation and activity in human small cell lung cancer cells.
Lung Neoplasms
Assessment of clonal expansion using CarcSeq measurement of lung cancer driver mutations and correlation with mouse strain- and sex-related incidence of spontaneous lung neoplasia.
Lung Neoplasms
Association between ATM polymorphisms and cancer risk: a meta-analysis.
Lung Neoplasms
Association of EGFR and KRAS mutations with expression of p-AKT, DR5 and DcR1 in non-small cell lung cancer.
Lung Neoplasms
Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy.
Lung Neoplasms
Association of protein kinase CK2 inhibition with cellular radiosensitivity of non-small cell lung cancer.
Lung Neoplasms
Association of ribosomal protein S6 kinase 1 with cellular radiosensitivity of non-small lung cancer.
Lung Neoplasms
Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non-Small Cell Lung Cancer.
Lung Neoplasms
Ataxia-telangiectasia mutated (ATM) participates in the regulation of ionizing radiation-induced cell death via MAPK14 in lung cancer H1299 cells.
Lung Neoplasms
Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
Lung Neoplasms
Atezolizumab prolongs overall survival over docetaxel in advanced non-small-cell lung cancer patients harboring STK11 or KEAP1 mutation.
Lung Neoplasms
ATM gene polymorphisms are associated with poor prognosis of non-small cell lung cancer receiving radiation therapy.
Lung Neoplasms
Aurora A, aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.
Lung Neoplasms
Aurora kinase inhibitors as anti-cancer therapy.
Lung Neoplasms
Aurora kinase targeting in lung cancer reduces KRAS-induced transformation.
Lung Neoplasms
Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3.
Lung Neoplasms
Baicalin attenuates DDP (cisplatin) resistance in lung cancer by downregulating MARK2 and p-Akt.
Lung Neoplasms
BAY-43-9006 Bayer/Onyx.
Lung Neoplasms
Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function.
Lung Neoplasms
Bmi-1 expression modulates non-small cell lung cancer progression.
Lung Neoplasms
BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas.
Lung Neoplasms
BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis.
Lung Neoplasms
Brief Report: Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients.
Lung Neoplasms
c-FLIP Downregulation Contributes to Apoptosis Induction by the Novel Synthetic Triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in Human Lung Cancer Cells.
Lung Neoplasms
c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.
Lung Neoplasms
c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha.
Lung Neoplasms
c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells.
Lung Neoplasms
cAMP signaling increases histone deacetylase 8 expression via the Epac2-Rap1A-Akt pathway in H1299 lung cancer cells.
Lung Neoplasms
Cancer-associated fibroblasts contribute to cisplatin resistance by modulating ANXA3 in lung cancer cells.
Lung Neoplasms
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.
Lung Neoplasms
Caveolin-1 knockdown increases the therapeutic sensitivity of lung cancer to cisplatin-induced apoptosis by repressing Parkin-related mitophagy and activating the ROCK1 pathway.
Lung Neoplasms
Cell-type-specific Modulation of Non-homologous End Joining of Gamma Ray-induced DNA Double-strand Breaks by cAMP Signaling in Human Cancer Cells.
Lung Neoplasms
Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.
Lung Neoplasms
Characterization of Aurora A and Its Impact on the Effect of Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer.
Lung Neoplasms
Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer.
Lung Neoplasms
Chimeric mouse models for lung adenocarcinomas.
Lung Neoplasms
Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism.
Lung Neoplasms
CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3.
Lung Neoplasms
Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPK? signaling in STK11 mutant lung cancer.
Lung Neoplasms
Circular RNA hsa_circ_0012673 facilitates lung cancer cell proliferation and invasion via miR-320a/LIMK18521 axis.
Lung Neoplasms
Cisplatin induces expression of drug resistance-related genes through c-jun N-terminal kinase pathway in human lung cancer cells.
Lung Neoplasms
Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer.
Lung Neoplasms
Combinations of laminin 5 with PTEN, p-EGFR and p-Akt define a group of distinct molecular subsets indicative of poor prognosis in patients with non-small cell lung cancer.
Lung Neoplasms
Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9.
Lung Neoplasms
Comparative Study of Autoantibody Responses between Lung Adenocarcinoma and Benign Pulmonary Nodules.
Lung Neoplasms
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.
Lung Neoplasms
Consistency and reproducibility of next-generation sequencing and other multigene mutational assays: A worldwide ring trial study on quantitative cytological molecular reference specimens.
Lung Neoplasms
Construction of a reference material panel for detecting KRAS/NRAS/EGFR/BRAF/MET mutations in plasma ctDNA.
Lung Neoplasms
Correction to: Wang Y et al., Association of ribosomal protein S6 kinase 1 with cellular radiosensitivity of non-small lung cancer.
Lung Neoplasms
Correlation between quantitative perfusion histogram parameters of DCE-MRI and PTEN, P-Akt and m-TOR in different pathological types of lung cancer.
Lung Neoplasms
Correlation between STK33 and the pathology and prognosis of lung cancer.
Lung Neoplasms
Correlation between the protein expression of A-kinase anchor protein 95, cyclin D3 and AKT and pathological indicators in lung cancer tissues.
Lung Neoplasms
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
Lung Neoplasms
Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad.
Lung Neoplasms
Current Status of Raf Kinase Inhibitor Protein (RKIP) in Lung Cancer: Behind RTK Signaling.
Lung Neoplasms
Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cells.
Lung Neoplasms
Death associated protein kinase: from regulation of apoptosis to tumor suppressive functions and B cell malignancies.
Lung Neoplasms
Decreased expression of 14-3-3 ?, an early event of malignant transformation of respiratory epithelium, also facilitates progression of squamous cell lung cancer.
Lung Neoplasms
Deep and Prolonged Response to Aurora A Kinase Inhibitor and Subsequently to Nivolumab in MYCL1-Driven Small-Cell Lung Cancer: Case Report and Literature Review.
Lung Neoplasms
DIAPH3 promotes the tumorigenesis of lung adenocarcinoma.
Lung Neoplasms
Different prognostic impact of STK11 mutations in non-squamous non-small-cell lung cancer.
Lung Neoplasms
Differential Kinase Activation in Peripheral Blood Mononuclear Cells from Non-Small-Cell Lung Cancer Patients Treated with Nivolumab.
Lung Neoplasms
Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.
Lung Neoplasms
Discovery of Rho-kinase inhibitors by docking-based virtual screening.
Lung Neoplasms
Disrupting the Rb-Raf-1 interaction: A potential therapeutic target for cancer.
Lung Neoplasms
DNA-PKc deficiency drives pre-malignant transformation by reducing DNA repair capacity in concert with reprogramming the epigenome in human bronchial epithelial cells.
Lung Neoplasms
Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1.
Lung Neoplasms
Downregulation of Pim-2 induces cell cycle arrest in the G
Lung Neoplasms
Doxorubicin induces expression of multidrug resistance-associated protein 1 in human small cell lung cancer cell lines by the c-jun N-terminal kinase pathway.
Lung Neoplasms
Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells.
Lung Neoplasms
Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study.
Lung Neoplasms
Effects of Ataxia Telangiectasia Mutated (ATM) Genotypes and Smoking Habits on Lung Cancer Risk in Taiwan.
Lung Neoplasms
Elevated expression levels of the 14-3-3 family of proteins in lung cancer tissues.
Lung Neoplasms
Elevated expression of G3BP1 associates with YB1 and p-AKT and predicts poor prognosis in nonsmall cell lung cancer patients after surgical resection.
Lung Neoplasms
Emerging Therapeutic Implications of STK11 Mutation: Case Series.
Lung Neoplasms
Endostatin sensitizes p53-deficient non-small-cell lung cancer to genotoxic chemotherapy by targeting DNA-dependent protein kinase catalytic subunit.
Lung Neoplasms
Enolase 1 differentially contributes to cell transformation in lung cancer but not in esophageal cancer.
Lung Neoplasms
Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer.
Lung Neoplasms
EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells.
Lung Neoplasms
Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors.
Lung Neoplasms
ERK Activation-Mediated Autophagy Induction Resists Licochalcone A-Induced Anticancer Activities in Lung Cancer Cells in vitro.
Lung Neoplasms
Establishment and Validation of Quantitative Real-time PCR Assay for Aberrant Methylation of 14-3-3? Gene in Breast and Lung Carcinoma.
Lung Neoplasms
Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase.
Lung Neoplasms
Evading the STING: LKB1 Loss Leads to STING Silencing and Immune Escape in KRAS-Mutant Lung Cancers.
Lung Neoplasms
Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors.
Lung Neoplasms
Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2.
Lung Neoplasms
Expression and prognostic significance of kit, protein kinase B, and mitogen-activated protein kinase in patients with small cell lung cancer.
Lung Neoplasms
Expression of phosphorylated mTOR and its clinical significances in small cell lung cancer.
Lung Neoplasms
Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival.
Lung Neoplasms
Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer.
Lung Neoplasms
FCH domain only 1 (FCHo1), a potential new biomarker for lung cancer.
Lung Neoplasms
FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin ?5 subunit and ROCK1.
Lung Neoplasms
Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors.
Lung Neoplasms
Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases.
Lung Neoplasms
Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma.
Lung Neoplasms
Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated.
Lung Neoplasms
GEM 231, a second-generation antisense agent complementary to protein kinase A RIalpha subunit, potentiates antitumor activity of irinotecan in human colon, pancreas, prostate and lung cancer xenografts.
Lung Neoplasms
Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients.
Lung Neoplasms
Gene of the month: STK11.
Lung Neoplasms
Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.
Lung Neoplasms
Genetic Ancestry Correlations with Driver Mutations Suggest Complex Interactions between Somatic and Germline Variation in Cancer.
Lung Neoplasms
Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk.
Lung Neoplasms
Germline mutations causing familial lung cancer.
Lung Neoplasms
Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization.
Lung Neoplasms
Glycogen synthase kinase-3 inhibition overcomes epithelial-mesenchymal transition-associated resistance to osimertinib in EGFR-mutant lung cancer.
Lung Neoplasms
GSK-3? inhibits autophagy and enhances radiosensitivity in non-small cell lung cancer.
Lung Neoplasms
Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model.
Lung Neoplasms
Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells.
Lung Neoplasms
Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer.
Lung Neoplasms
Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer.
Lung Neoplasms
Identification of Key Genes and Pathways in Female Lung Cancer Patients Who Never Smoked by a Bioinformatics Analysis.
Lung Neoplasms
Immunocytochemical detection of lung cancer cells with monoclonal antibodies to 14-3-3 proteins.
Lung Neoplasms
Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage.
Lung Neoplasms
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy.
Lung Neoplasms
Impact of KRAS and TP53 Co-Mutations on Outcomes After First-Line Systemic Therapy Among Patients With STK11-Mutated Advanced Non-Small-Cell Lung Cancer.
Lung Neoplasms
In silico and invitro approaches to evaluate the bioactivity of Cassia auriculata L extracts.
Lung Neoplasms
Inactivation of AKT/NF??B signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin.
Lung Neoplasms
Increased phospho-AKT (Ser(473)) expression in bronchial dysplasia: implications for lung cancer prevention studies.
Lung Neoplasms
Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.
Lung Neoplasms
Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer.
Lung Neoplasms
Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway.
Lung Neoplasms
Inhibition of Aurora A enhances radiosensitivity in selected lung cancer cell lines.
Lung Neoplasms
Inhibition of c-Jun N-terminal kinase signaling increased apoptosis and prevented the emergence of ALK-TKI-tolerant cells in ALK-rearranged non-small cell lung cancer.
Lung Neoplasms
Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer.
Lung Neoplasms
Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy.
Lung Neoplasms
Inhibition of CK2 enhances UV-triggered apoptotic cell death in lung cancer cell lines.
Lung Neoplasms
Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation.
Lung Neoplasms
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Lung Neoplasms
Inhibition of protein kinase CK2 sensitizes non-small cell lung cancer cells to cisplatin via upregulation of PML.
Lung Neoplasms
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer.
Lung Neoplasms
Integrated analysis of transcriptomes of cancer cell lines and patient samples reveals STK11/LKB1-driven regulation of cAMP phosphodiesterase-4D.
Lung Neoplasms
Interaction of ribosomal protein L22 with casein kinase 2?: a novel mechanism for understanding the biology of non-small cell lung cancer.
Lung Neoplasms
Interleukin 6 trigged ataxia-telangiectasia mutated activation facilitates lung cancer metastasis via MMP-3/MMP-13 up-regulation.
Lung Neoplasms
Interleukin 6-triggered ataxia-telangiectasia mutated kinase activation facilitates epithelial-to-mesenchymal transition in lung cancer by upregulating vimentin expression.
Lung Neoplasms
Interleukin-22 (IL-22) Regulates Apoptosis of Paclitaxel-Resistant Non-Small Cell Lung Cancer Cells Through C-Jun N-Terminal Kinase Signaling Pathway.
Lung Neoplasms
Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells.
Lung Neoplasms
Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues.
Lung Neoplasms
Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
Lung Neoplasms
Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancer cell line harboring T790M mutation.
Lung Neoplasms
Knocking Down Nucleolin Expression Enhances the Radiosensitivity of Non-Small Cell Lung Cancer by Influencing DNA-PKcs Activity.
Lung Neoplasms
KRAS: Reasons for optimism in lung cancer.
Lung Neoplasms
Kruppel-like factor 4 inhibits non-small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-?1-meidated ERK/JNK/NF-?B signaling pathways.
Lung Neoplasms
Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.
Lung Neoplasms
LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells.
Lung Neoplasms
LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor.
Lung Neoplasms
LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
Lung Neoplasms
LKB1/STK11 Suppresses Cyclooxygenase-2 Induction and Cellular Invasion through PEA3 in Lung Cancer.
Lung Neoplasms
LKB1: cancer, polarity, metabolism, and now fertility.
Lung Neoplasms
lncRNA SLC16A1-AS1 as a novel prognostic biomarker in non-small cell lung cancer.
Lung Neoplasms
Long duration of immunotherapy in a STK11 mutated/KRAS wild-type non-small cell lung cancer patient.
Lung Neoplasms
Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non-Small-Cell Lung Cancer.
Lung Neoplasms
Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Lung Neoplasms
Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism.
Lung Neoplasms
Lung but not brain cancer cell malignancy inhibited by commonly used anesthetic propofol during surgery: Implication of reducing cancer recurrence risk.
Lung Neoplasms
Lung cancer-reacting human recombinant antibody AE6F4: potential usefulness in the sputum cytodiagnosis.
Lung Neoplasms
MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer.
Lung Neoplasms
MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1.
Lung Neoplasms
MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines.
Lung Neoplasms
Metformin induces apoptotic cytotoxicity depending on AMPK/PKA/GSK-3?-mediated c-FLIPL degradation in non-small cell lung cancer.
Lung Neoplasms
Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation.
Lung Neoplasms
Methylseleninic acid overcomes programmed death-ligand 1-mediated resistance of prostate cancer and lung cancer.
Lung Neoplasms
MicroRNA-137-regulated AKT serine/threonine kinase 2 inhibits tumor growth and sensitizes cisplatin in patients with non-small cell lung cancer.
Lung Neoplasms
MicroRNA-148a suppresses epithelial-to-mesenchymal transition by targeting ROCK1 in non-small cell lung cancer cells.
Lung Neoplasms
MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells.
Lung Neoplasms
Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer.
Lung Neoplasms
miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK.
Lung Neoplasms
miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein.
Lung Neoplasms
miR-193a-3p inhibition of the Slug activator PAK4 suppresses non-small cell lung cancer aggressiveness via the p53/Slug/L1CAM pathway.
Lung Neoplasms
miR-335-5p inhibits TGF-?1-induced epithelial-mesenchymal transition in non-small cell lung cancer via ROCK1.
Lung Neoplasms
MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells.
Lung Neoplasms
miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression.
Lung Neoplasms
Modulating Tumor Microenvironment: A Review on STK11 Immune Properties and Predictive vs Prognostic Role for Non-small-cell Lung Cancer Immunotherapy.
Lung Neoplasms
Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228.
Lung Neoplasms
Multiple primary malignant neoplasms: A case report and literature review.
Lung Neoplasms
Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11.
Lung Neoplasms
Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers.
Lung Neoplasms
No Association between Promoter Polymorphism of STK11 Gene and Lung Cancer Risk in the Korean Population.
Lung Neoplasms
Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
Lung Neoplasms
Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors.
Lung Neoplasms
Nuclear survivin and its relationship to DNA damage repair genes in non-small cell lung cancer investigated using tissue array.
Lung Neoplasms
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Lung Neoplasms
Overexpression and Selective Anticancer Efficacy of ENO3 in STK11 Mutant Lung Cancers.
Lung Neoplasms
Overexpression of 14-3-3gamma causes polyploidization in H322 lung cancer cells.
Lung Neoplasms
Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer.
Lung Neoplasms
Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion.
Lung Neoplasms
Overexpression of T-LAK cell-originated protein kinase predicts poor prognosis in patients with stage I lung adenocarcinoma.
Lung Neoplasms
Overexpression of the LKB1 gene inhibits lung carcinoma cell proliferation partly through degradation of c-myc protein.
Lung Neoplasms
p53 regulates cellular responses to environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide in human lung cancer cells.
Lung Neoplasms
P53 suppresses expression of the 14-3-3gamma oncogene.
Lung Neoplasms
p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer.
Lung Neoplasms
Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells.
Lung Neoplasms
Parathyroid hormone-related protein regulates apoptosis in lung cancer cells through protein kinase A.
Lung Neoplasms
PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.
Lung Neoplasms
PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer.
Lung Neoplasms
PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-?B, and ?-catenin signalings.
Lung Neoplasms
Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.
Lung Neoplasms
Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer.
Lung Neoplasms
Phosphorylated-Akt overexpression is associated with a higher risk of brain metastasis in patients with non-small cell lung cancer.
Lung Neoplasms
PIM1-activated PRAS40 regulates radioresistance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases.
Lung Neoplasms
Placenta growth factor, PLGF, influences the motility of lung cancer cells, the role of Rho associated kinase, Rock1.
Lung Neoplasms
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells.
Lung Neoplasms
Primary Resistance to Immune Checkpoint Blockade in an STK11/TP53/KRAS-Mutant Lung Adenocarcinoma with High PD-L1 Expression.
Lung Neoplasms
Profiling Oncogenic Germline Mutations in Unselected Chinese Lung Cancer Patients.
Lung Neoplasms
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
Lung Neoplasms
Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer.
Lung Neoplasms
Prognostic significance of nuclear or cytoplasmic nucleolin expression in human non-small cell lung cancer and its relationship with DNA-PKcs.
Lung Neoplasms
Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer.
Lung Neoplasms
Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers.
Lung Neoplasms
Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.
Lung Neoplasms
Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C.
Lung Neoplasms
Protein Kinase D1 Is Increased in Tumor Tissue, Correlates With Advanced Tumor Features and Worse Prognosis of Non-Small Cell Lung Cancer.
Lung Neoplasms
Proteomic analysis of media from lung cancer cells reveals role of 14-3-3 proteins in cachexia.
Lung Neoplasms
Proteomic Analysis of Proteins Related to Prognosis of Lung Adenocarcinoma.
Lung Neoplasms
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Lung Neoplasms
Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells.
Lung Neoplasms
Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells.
Lung Neoplasms
RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Lung Neoplasms
Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis.
Lung Neoplasms
Recurrent inactivating mutations of ARID2 in non-small cell lung carcinoma.
Lung Neoplasms
Reduced RKIP expression levels are associated with frequent non-small cell lung cancer metastasis and STAT3 phosphorylation and activation.
Lung Neoplasms
Reduction of 14-3-3 proteins correlates with increased sensitivity to killing of human lung cancer cells by ionizing radiation.
Lung Neoplasms
Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer.
Lung Neoplasms
Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells.
Lung Neoplasms
Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1alpha in non-small cell lung cancers.
Lung Neoplasms
Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
Lung Neoplasms
Repression of PDK1- and LncRNA HOTAIR-Mediated EZH2 Gene Expression Contributes to the Enhancement of Atractylenolide 1 and Erlotinib in the Inhibition of Human Lung Cancer Cells.
Lung Neoplasms
Resistance to durvalumab and durvalumab plus tremelimumab is associated with functional STK11 mutations in non-small-cell lung cancer patients and is reversed by STAT3 knockdown.
Lung Neoplasms
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Lung Neoplasms
ROCK1 and ROCK2 are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion.
Lung Neoplasms
ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating the LATS2-JNK signaling pathway.
Lung Neoplasms
ROCK1 promotes migration and invasion of non?small?cell lung cancer cells through the PTEN/PI3K/FAK pathway.
Lung Neoplasms
Role of next generation sequencing-based liquid biopsy in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: impact of STK11, KRAS and TP53 mutations and co-mutations on outcome.
Lung Neoplasms
Role of p27Kip1 and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer.
Lung Neoplasms
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Lung Neoplasms
Roles of protein kinase B/Akt in lung cancer.
Lung Neoplasms
Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer.
Lung Neoplasms
Selective expression and immunogenicity of the cancer/testis antigens SP17, AKAP4 and PTTG1 in non-small cell lung cancer: new candidates for active immunotherapy.
Lung Neoplasms
Silencing of KCNK15-AS1 inhibits lung cancer cell proliferation via upregulation of miR-202 and miR-370.
Lung Neoplasms
STK11 alterations in the pan-cancer setting: prognostic and therapeutic implications.
Lung Neoplasms
STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort.
Lung Neoplasms
STK11 p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors.
Lung Neoplasms
STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential.
Lung Neoplasms
STK33-dependent transcriptional regulation of SFTA3 induces Cisplatin-resistance in lung adenocarcinoma.
Lung Neoplasms
Study of EGCG induced apoptosis in lung cancer cells by inhibiting PI3K/Akt signaling pathway.
Lung Neoplasms
STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.
Lung Neoplasms
STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma.
Lung Neoplasms
STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling.
Lung Neoplasms
Suppression of AKT expression by miR-153 produced anti-tumor activity in lung cancer.
Lung Neoplasms
Suppression of cyclooxygenase 2 increases chemosensitivity to sesamin through the Akt?PI3K signaling pathway in lung cancer cells.
Lung Neoplasms
Survival analysis for non-squamous NSCLC patients harbored STK11 or KEAP1 mutation receiving atezolizumab.
Lung Neoplasms
Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.
Lung Neoplasms
Targeted Lung Cancer Treatments and Eye Metastasis.
Lung Neoplasms
Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.
Lung Neoplasms
Targeting LUNX Inhibits Non-Small Cell Lung Cancer Growth and Metastasis.
Lung Neoplasms
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
Lung Neoplasms
Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products.
Lung Neoplasms
TGF?-induced Lung Cancer Cell Migration Is NR4A1-dependent.
Lung Neoplasms
The 14-3-3 protein as the antigen for lung cancer-associated human monoclonal antibody AE6F4.
Lung Neoplasms
The Akt/mTOR and mitogen-activated protein kinase pathways in lung cancer therapy.
Lung Neoplasms
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Lung Neoplasms
The apoptotic effect of GSK-3 inhibitors: BIO and CHIR 98014 on H1975 lung cancer cells through ROS generation and mitochondrial dysfunction.
Lung Neoplasms
The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation.
Lung Neoplasms
The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells.
Lung Neoplasms
The effect of ionizing radiation on the subcellular localization and kinase activity of protein kinase CK2 in human non-small cell lung cancer cells.
Lung Neoplasms
The functional significance of 14-3-3 proteins in cancer: focus on lung cancer.
Lung Neoplasms
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.
Lung Neoplasms
The influence of STK11 mutation on acquired resistance to immunotherapy in advanced non-small cell lung cancer with Lynch syndrome: a case report and literature review.
Lung Neoplasms
The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway.
Lung Neoplasms
The promoter region of the human BUBR1 gene and its expression analysis in lung cancer.
Lung Neoplasms
The Role and Mechanism of ATM-Mediated Autophagy in the Transition From Hyper-Radiosensitivity to Induced Radioresistance in Lung Cancer Under Low-Dose Radiation.
Lung Neoplasms
The role of the ataxia telangiectasia mutated gene in lung cancer: recent advances in research.
Lung Neoplasms
The synthetic peptide CIGB-300 modulates CK2-dependent signaling pathways affecting the survival and chemoresistance of non-small cell lung cancer cell lines.
Lung Neoplasms
TM4SF4 and LRRK2 are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis.
Lung Neoplasms
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.
Lung Neoplasms
Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.
Lung Neoplasms
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Lung Neoplasms
WEE1 Kinase Inhibitor AZD1775 Has Preclinical Efficacy in LKB1-Deficient Non-Small Cell Lung Cancer.
Lung Neoplasms
Wilms' tumour suppressor gene 1 (WT1) is involved in the carcinogenesis of Lung cancer through interaction with PI3K/Akt pathway.
Lung Neoplasms
[Analyzed the molecular interaction network of tumor suppressor gene 14-3-3 sigma in lung cancer cell based on stable isotope labeling by amino acids in cell culture technology].
Lung Neoplasms
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines.]
Lung Neoplasms
[Correlation of P27 expression and localization to phosphorylated AKT in non-small cell lung cancer]
Lung Neoplasms
[Current status of Akt in non-small cell lung cancer].
Lung Neoplasms
[Effect of basic fibroblast growth factor antibody combined with irinotecan on proliferation and apoptosis of small cell lung cancer H223 cells in vitro].
Lung Neoplasms
[Effect of inhibiting the expression of hSMG-1 on chemosensitivity of human non-small cell lung cancer H1299 cells.]
Lung Neoplasms
[Epidermal growth factor receptor aberrations in malignant mesotheliomas]
Lung Neoplasms
[Expression and clinical significance of Ku70, Ku80 and DNA-PKcs proteins in patients with stageI-II non-small cell lung cancer by tissue microarray.]
Lung Neoplasms
[Expression of A-kinase anchor protein 95, cyclin E2, and connexin 43 in lung cancer tissue, clinical significance of their expression, and their expression correlation].
Lung Neoplasms
[Medical treatment of small cell lung cancer: Can we leave the area of cisplatin-etoposide?]
Lung Neoplasms
[Prognostic value of combined expression of Aurora A, p53 and p21 WAF1 in patients after curative resection of non-small cell lung cancer].
Lung Neoplasms
[Relationship between AKAP95, cyclin E1, cyclin D1, and clinicopathological parameters in lung cancer tissue].
Lung Neoplasms
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
Lung Neoplasms
[The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.]
Lung Neoplasms
[The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.]
Lupus Erythematosus, Systemic
Alterations in C3 activation and binding caused by phosphorylation by a casein kinase released from activated human platelets.
Lupus Erythematosus, Systemic
Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.
Lupus Erythematosus, Systemic
Autophagy-related gene LRRK2 is likely a susceptibility gene for systemic lupus erythematosus in northern Han Chinese.
Lupus Erythematosus, Systemic
Deficient protein kinase a in systemic lupus erythematosus: a disorder of T lymphocyte signal transduction.
Lupus Erythematosus, Systemic
Differential expression of serine-threonine kinase receptor-associated protein in patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Lupus Erythematosus, Systemic
Glucocorticoid receptor, nuclear factor kappaB, activator protein-1 and C-jun N-terminal kinase in systemic lupus erythematosus patients.
Lupus Erythematosus, Systemic
High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Identifying Crosstalk between Raf Kinase Inhibitor Protein and Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
Podocytes and autophagy: a potential therapeutic target in lupus nephritis.
Lupus Erythematosus, Systemic
Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells.
Lupus Erythematosus, Systemic
The effect of circulating serum factors from patients with systemic lupus erythematosus on protein kinase A (PKA) activity and PKA-dependent protein phosphorylation in T lymphocytes.
Lupus Nephritis
Exploring new territory: considering the future.
Lupus Nephritis
Podocytes and autophagy: a potential therapeutic target in lupus nephritis.
Lymphangioleiomyomatosis
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM).
Lymphatic Metastasis
A meta-analysis evaluating the relationship between B-type Raf kinase mutation and cervical lymphatic metastasis in papillary thyroid cancer.
Lymphatic Metastasis
A three gene-based risk score predicts prognosis of resected non-small-cell lung cancer.
Lymphatic Metastasis
Aberrant expression of STYK1 and E-cadherin confer a poor prognosis for pancreatic cancer patients.
Lymphatic Metastasis
Aberrant methylation profile of 14-3-3 sigma and its reduced transcription/expression levels in Chinese sporadic female breast carcinogenesis.
Lymphatic Metastasis
Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma.
Lymphatic Metastasis
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
Lymphatic Metastasis
Assessment of the methods used to detect HER2-positive advanced extramammary Paget's disease.
Lymphatic Metastasis
Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer.
Lymphatic Metastasis
Association of EGFR and KRAS mutations with expression of p-AKT, DR5 and DcR1 in non-small cell lung cancer.
Lymphatic Metastasis
Blocking PI3K/Akt signaling attenuates metastasis of nasopharyngeal carcinoma cells through induction of mesenchymal-epithelial reverting transition.
Lymphatic Metastasis
BRAF V600E Mutation Independently Predicts Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Cancer.
Lymphatic Metastasis
Breast Carcinoma-associated Fibroblasts Share Similar Biomarker Profiles in Matched Lymph Node Metastasis.
Lymphatic Metastasis
Characterization of Aurora A and Its Impact on the Effect of Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer.
Lymphatic Metastasis
Cytoplasmic accumulation of glycogen synthase kinase-3beta is associated with aggressive clinicopathological features in human prostate cancer.
Lymphatic Metastasis
DCAMKL1 is associated with the malignant status and poor outcome in bladder cancer.
Lymphatic Metastasis
Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas.
Lymphatic Metastasis
Differential expression of HER2 and downstream proteins in prediction of advanced tumor phenotypes and overall survival of patients with Epstein-Barr virus-positive vs. negative gastric cancers.
Lymphatic Metastasis
Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas.
Lymphatic Metastasis
DNA-PKcs and Ku70 are predictive markers for poor prognosis of patients with gall bladder malignancies.
Lymphatic Metastasis
Expression and clinical significance of the phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway in non-small cell lung carcinoma.
Lymphatic Metastasis
Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma.
Lymphatic Metastasis
Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.
Lymphatic Metastasis
Expression of p-Akt in ovarian serous carcinoma and its association with proliferation and apoptosis.
Lymphatic Metastasis
Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis.
Lymphatic Metastasis
Gene sequencing and expression of Raf-1 in lymphatic metastasis of hypopharyngeal carcinoma.
Lymphatic Metastasis
Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.
Lymphatic Metastasis
Head-to-head comparison of the impact of Aurora A, Aurora B, Repp86, CDK1, CDK2 and Ki67 expression in two of the most relevant gynaecological tumor entities.
Lymphatic Metastasis
HIPK2 inhibits cell metastasis and improves chemosensitivity in esophageal squamous cell carcinoma.
Lymphatic Metastasis
Identification of Aurora Kinase A as a Biomarker for Prognosis in Obesity Patients with Early Breast Cancer.
Lymphatic Metastasis
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis.
Lymphatic Metastasis
ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway.
Lymphatic Metastasis
Inactivation of homeodomain-interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53-dependent E-cadherin expression.
Lymphatic Metastasis
Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma.
Lymphatic Metastasis
Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer.
Lymphatic Metastasis
Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma.
Lymphatic Metastasis
Inhibition of phosphoinositide 3-kinase/Akt pathway decreases hypoxia inducible factor-1? expression and increases therapeutic efficacy of paclitaxel in human hypoxic gastric cancer cells.
Lymphatic Metastasis
Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway.
Lymphatic Metastasis
Long Noncoding RNAs Coregulated by Annexin A7 and JNK in Hepatocellular Carcinoma Cells Identified by Whole-Genome Expression Profiling.
Lymphatic Metastasis
Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers.
Lymphatic Metastasis
Loss of Raf-1 kinase inhibitor protein expression is associated with lymph node metastasis in papillary thyroid cancer.
Lymphatic Metastasis
MicroRNA 135a Suppresses Lymph Node Metastasis through Down-Regulation of ROCK1 in Early Gastric Cancer.
Lymphatic Metastasis
miR-335-5p inhibits TGF-?1-induced epithelial-mesenchymal transition in non-small cell lung cancer via ROCK1.
Lymphatic Metastasis
NEAT1/miR-101-dependent Up-regulation of DNA-PKcs Enhances Malignant Behaviors of Pancreatic Ductal Adenocarcinoma Cells.
Lymphatic Metastasis
Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer.
Lymphatic Metastasis
Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis.
Lymphatic Metastasis
Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.
Lymphatic Metastasis
p-Akt and its relationship with clinicopathological features and survival in oral squamous cell carcinoma: an immunohistochemical study.
Lymphatic Metastasis
Patterns of gene promoter methylation in squamous cell cancer of the head and neck.
Lymphatic Metastasis
PD-L1, PDK-1 and p-Akt are correlated in patients with papillary thyroid carcinoma.
Lymphatic Metastasis
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Lymphatic Metastasis
Prognostic value of activated Akt expression in oral squamous cell carcinoma.
Lymphatic Metastasis
Protein Kinase D1 Is Increased in Tumor Tissue, Correlates With Advanced Tumor Features and Worse Prognosis of Non-Small Cell Lung Cancer.
Lymphatic Metastasis
Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma.
Lymphatic Metastasis
Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer.
Lymphatic Metastasis
RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma.
Lymphatic Metastasis
Role of serine/threonine kinase 33 methylation in colorectal cancer and its clinical significance.
Lymphatic Metastasis
Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy.
Lymphatic Metastasis
STK33 promotes the growth and progression of human pancreatic neuroendocrine tumour via activation of the PI3K/AKT/mTOR pathway.
Lymphatic Metastasis
Stratifin accelerates progression of lung adenocarcinoma at an early stage.
Lymphatic Metastasis
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
Lymphatic Metastasis
The clinicopathological and prognostic impact of 14-3-3 protein isoforms expression in human cholangiocarcinoma by immunohistochemistry.
Lymphatic Metastasis
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance.
Lymphatic Metastasis
Up-regulation of LIMK1 expression in prostate cancer is correlated with poor pathological features, lymph node metastases and biochemical recurrence.
Lymphatic Metastasis
Upregulation of Stress-Induced Protein Kinase CK1 Delta is associated with a Poor Prognosis for patients with Hepatocellular Carcinoma.
Lymphatic Metastasis
[Correlation of p38 mitogen-activated protein kinase signal transduction pathway to uPA expression in breast cancer]
Lymphatic Metastasis
[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer]
Lymphatic Metastasis
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Lymphatic Metastasis
[Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]
Lymphatic Metastasis
[The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.]
Lymphatic Metastasis
[The relationship between PTEN expression and PI3K/AKT signal pathway in colon carcinoma]
Lymphocytic Choriomeningitis
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.
Lymphocytic Choriomeningitis
Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3.
Lymphoma
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors.
Lymphoma
A key role for protein kinase A in homologous desensitization of the beta 2-adrenergic receptor pathway in S49 lymphoma cells.
Lymphoma
Actionable driver DNA variants and fusion genes can be detected in archived cytological specimens with the Oncomine Dx Target Test Multi-CDx system in lung cancer.
Lymphoma
Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.
Lymphoma
Adequacy of small biopsy and cytology specimens for comprehensive genomic profiling of patients with non-small-cell lung cancer to determine eligibility for immune checkpoint inhibitor and targeted therapy.
Lymphoma
Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2.
Lymphoma
ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells.
Lymphoma
Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line.
Lymphoma
Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition.
Lymphoma
Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats.
Lymphoma
Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a d-Galactose-Induced Aging Heart.
Lymphoma
Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Lymphoma
Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra.
Lymphoma
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
Lymphoma
ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence?
Lymphoma
ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.
Lymphoma
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
Lymphoma
Autocrine motility factor receptor promotes the proliferation of human acute monocytic leukemia THP-1 cells.
Lymphoma
B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase.
Lymphoma
Beta(3)-mediated engulfment of apoptotic tumor cells by dendritic cells is dependent on CAMKII: inhibition by HIV-1 Tat.
Lymphoma
Biological and clinical significance of GSK-3beta in mantle cell lymphoma--an immunohistochemical study.
Lymphoma
c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells.
Lymphoma
Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling.
Lymphoma
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
Lymphoma
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle.
Lymphoma
CD30 Induces Heat Shock Protein 90 and Signal Integration in Classic Hodgkin Lymphoma Cells.
Lymphoma
CD5(-) diffuse large B-cell lymphoma with peculiar cyclin D1+ phenotype. Pathologic and molecular characterization of a single case.
Lymphoma
Characterization of TAE684 as a potent LRRK2 kinase inhibitor.
Lymphoma
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells.
Lymphoma
Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis.
Lymphoma
Complex Effects of Putative DRP-1 Inhibitors on Stress Responses in Mouse Heart and Rat Cardiomyoblasts.
Lymphoma
Computational algorithms for in silico profiling of activating mutations in cancer.
Lymphoma
Convergence of CpG DNA- and BCR-mediated signals at the c-Jun N-terminal kinase and NF-kappaB activation pathways: regulation by mitogen-activated protein kinases.
Lymphoma
Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
Lymphoma
CX-4945, a selective inhibitor of casein kinase 2, synergizes with B cell receptor signaling inhibitors in inducing diffuse large B cell lymphoma cell death.
Lymphoma
Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger.
Lymphoma
Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA.
Lymphoma
Death associated protein kinase: from regulation of apoptosis to tumor suppressive functions and B cell malignancies.
Lymphoma
Diagnostic Accuracy of Next Generation Sequencing Panel using Circulating Tumor DNA in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Lymphoma
Dietary n-3 PUFA Deficiency Increases Vulnerability to Scopolamine-Induced Cognitive Impairment in Male C57BL/6 Mice.
Lymphoma
Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-SY5Y cells.
Lymphoma
Diosmetin inhibits cell proliferation and induces apoptosis by regulating autophagy via the mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells.
Lymphoma
DIXDC1 promotes tumor proliferation and cell adhesion mediated drug resistance (CAM-DR) via enhancing p-Akt in Non-Hodgkin's lymphomas.
Lymphoma
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
Lymphoma
Drug resistance to targeted therapeutic strategies in non-small cell lung cancer.
Lymphoma
Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas.
Lymphoma
Effect of docetaxel on the regulation of proliferation and apoptosis of human prostate cancer cells.
Lymphoma
Effects of CDC7 gene silencing and Rituximab on apoptosis in diffuse large B cell lymphoma cells.
Lymphoma
EGFR, ALK, RET, KRAS and BRAF alterations in never-smokers with non-small cell lung cancer.
Lymphoma
Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.
Lymphoma
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment.
Lymphoma
Epigenetic changes in the DAP-kinase CpG island in pediatric lymphoma.
Lymphoma
Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas.
Lymphoma
Expression of Akt (protein kinase B) and its isoforms in malignant lymphomas.
Lymphoma
Expression of PIM-2 and NF-?B genes is increased in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and is associated with complete remission rate and overall survival.
Lymphoma
Familial lymphoid neoplasms in patients with mantle cell lymphoma Familial lymphoid neoplasms in patients with mantle cell lymphoma.
Lymphoma
Ganetespib: research and clinical development.
Lymphoma
GSK-3beta inhibition: at the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma.
Lymphoma
HA1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Ca2+-mediated apoptosis through a protein kinase A-independent mechanism.
Lymphoma
Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4/ROS-MAPK pathway.
Lymphoma
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Lymphoma
Hipk2 cooperates with p53 to suppress ?-ray radiation-induced mouse thymic lymphoma.
Lymphoma
Human trypsin inhibitor reduces the apoptosis of lipopolysaccharide?induced human kidney?2 cells by promoting mitochondrial fusion.
Lymphoma
Hyaluronan oligosaccharides sensitize lymphoma resistant cell lines to vincristine by modulating P-glycoprotein activity and PI3K/Akt pathway.
Lymphoma
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.
Lymphoma
Identification of a novel crosstalk between casein kinase 2? and NPM-ALK in ALK-positive anaplastic large cell lymphoma.
Lymphoma
Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1.
Lymphoma
Immunohistochemical studies of protein kinase D (PKD) 2 expression in malignant human lymphomas.
Lymphoma
Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma.
Lymphoma
Induction of oxidative stress and the transcription of genes related to apoptosis in rare minnow (Gobiocypris rarus) larvae with Aroclor 1254 exposure.
Lymphoma
Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma.
Lymphoma
Inhibition of MEK induces fas expression and apoptosis in lymphomas overexpressing Ras.
Lymphoma
Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.
Lymphoma
Inhibition of the PI3K/AKT-NF-?B pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt's lymphoma.
Lymphoma
Intravascular large B-cell lymphoma: report of three cases and analysis of the mTOR pathway.
Lymphoma
Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells.
Lymphoma
Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation.
Lymphoma
Knockdown of the Hippo transducer YAP reduces proliferation and promotes apoptosis in the Jurkat leukemia cell.
Lymphoma
KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.
Lymphoma
Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth.
Lymphoma
Losartan improves erectile function through suppression of corporal apoptosis and oxidative stress in rats with cavernous nerve injury.
Lymphoma
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.
Lymphoma
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
Lymphoma
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation.
Lymphoma
Lymphomagenesis-related gene expression in B cells from sustained virological responders with occult hepatitis C virus infection.
Lymphoma
Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-?B and JNK activation.
Lymphoma
Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism.
Lymphoma
Management of relapses after hematopoietic cell transplantation in T-cell non-Hodgkin lymphomas.
Lymphoma
Molecular alterations in non-small cell lung carcinomas of the young.
Lymphoma
Molecular characterization of common variable immunodeficiency-related lymphomas.
Lymphoma
MOP-dependent enhancement of methadone on the effectiveness of ALA-PDT for A172 cells by upregulating phosphorylated JNK and BCL2.
Lymphoma
Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter.
Lymphoma
Multiplex Diagnosis of Oncogenic Fusion and MET Exon Skipping by Molecular Counting Using Formalin-Fixed Paraffin Embedded Lung Adenocarcinoma Tissues.
Lymphoma
Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma.
Lymphoma
Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma.
Lymphoma
Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens.
Lymphoma
Nek2 is a novel regulator of B cell development and immunological response.
Lymphoma
Novel Therapeutic Targets in Non-small Cell Lung Cancer.
Lymphoma
On the spontaneous mutability of CpG sites in cultured S49 mouse lymphoma cells.
Lymphoma
PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.
Lymphoma
Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib in Adult Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Dysfunction.
Lymphoma
Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose.
Lymphoma
Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma.
Lymphoma
Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
Lymphoma
Phase II Study of Alisertib, a Selective Aurora A Kinase Inhibitor, in Relapsed and Refractory Aggressive B- and T-Cell Non-Hodgkin Lymphomas.
Lymphoma
Physiological phosphorylation of protein kinase A at Thr-197 is by a protein kinase A kinase.
Lymphoma
Pim kinase-dependent inhibition of c-Myc degradation.
Lymphoma
Pim kinases in hematological malignancies: where are we now and where are we going?
Lymphoma
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.
Lymphoma
Pim-1 associates with protein complexes necessary for mitosis.
Lymphoma
Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway.
Lymphoma
Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects.
Lymphoma
PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas.
Lymphoma
Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity.
Lymphoma
Possible role for protein kinase B in the anti-apoptotic effect of prolactin in rat Nb2 lymphoma cells.
Lymphoma
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Lymphoma
Pretreatment 14-3-3 epsilon level is predictive for advanced extranodal NK/T cell lymphoma therapeutic response to asparaginase-based chemotherapy.
Lymphoma
Primary Central Nervous System Lymphoma Presenting as Parkinsonism with Atypical MRI Findings and Elevated 14-3-3 Protein.
Lymphoma
Primary malignant lymphoma of the brain: analysis of MMAC1 (PTEN) tumor suppressor gene.
Lymphoma
Profiling Oncogenic Germline Mutations in Unselected Chinese Lung Cancer Patients.
Lymphoma
Protein Kinase CK2 Inhibition Down Modulates the NF-?B and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells.
Lymphoma
Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth.
Lymphoma
Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A.
Lymphoma
Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway.
Lymphoma
RAF-1 over-expression does condition survival of patients affected by aggressive mantle cell lymphoma.
Lymphoma
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.
Lymphoma
Redundant and nonredundant functions of ATM and H2AX in ?? T-lineage lymphocytes.
Lymphoma
Regulation of apoptosis by cyclic nucleotides in human erythroleukemia (HEL) cells and human myelogenous leukemia (K-562) cells.
Lymphoma
Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen.
Lymphoma
Role of hypermethylation of DAP-kinase CpG island in the development of thyroid lymphoma.
Lymphoma
Serine-227 in the N-terminal kinase domain of RSK2 is a potential therapeutic target for mantle cell lymphoma.
Lymphoma
Serine/Threonine Kinase Pim-2 Promotes Liver Tumorigenesis Induction Through Mediating Survival and Preventing Apoptosis of Liver Cell.
Lymphoma
Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.
Lymphoma
Silencing of RHEB inhibits cell proliferation and promotes apoptosis in colorectal cancer cells via inhibition of the mTOR signaling pathway.
Lymphoma
Statins as the Controlling Agents for Non-Hodgkin's Lymphomas via Increasing the Casein Kinase 2 Interacting Protein-1: A Hypothesis.
Lymphoma
STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma.
Lymphoma
Stra8 may inhibit apoptosis during mouse spermatogenesis via the AKT signaling pathway.
Lymphoma
Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.
Lymphoma
Targeted Lung Cancer Treatments and Eye Metastasis.
Lymphoma
Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma.
Lymphoma
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Lymphoma
The effects of high glucose levels on reactive oxygen species-induced apoptosis and involved signaling in human vascular endothelial cells.
Lymphoma
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta.
Lymphoma
The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors.
Lymphoma
The PARP inhibitor olaparib induces significant killing of ATM deficient lymphoid tumour cells in vitro and in vivo.
Lymphoma
The protective effects of exogenous spermine on renal ischemia-reperfusion injury in rats.
Lymphoma
The role of aurora A and polo-like kinases in high-risk lymphomas.
Lymphoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Lymphoma
Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in vitro.
Lymphoma
Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors.
Lymphoma
Tumor necrosis factor ? sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner.
Lymphoma
Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma.
Lymphoma
Ubiquitous expression and cell cycle regulation of the protein kinase PIM-1.
Lymphoma
Understanding and targeting resistance mechanisms in NSCLC.
Lymphoma
[Effects of AKT protein kinase activation on biologic behavior of diffuse large B cell lymphoma cells]
Lymphoma
[Hypermethylation of DAP-kinase gene CpG Island in malignant lymphoma with B-cell phenotype]
Lymphoma
[Mechanism of apoptin-induced apoptosis of human lymphoma cells U937.]
Lymphoma
[Study on activation of AKT/mTOR pathway in anaplastic large cell lymphoma]
Lymphoma, B-Cell
A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma.
Lymphoma, B-Cell
Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells.
Lymphoma, B-Cell
Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway.
Lymphoma, B-Cell
An enzymatically fortified ginseng extract inhibits proliferation and induces apoptosis of KATO3 human gastric cancer cells via modulation of Bax, mTOR, PKB and I?B?.
Lymphoma, B-Cell
Androgen depletion alters the diurnal patterns to signals that regulate autophagy in the limb skeletal muscle.
Lymphoma, B-Cell
Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats.
Lymphoma, B-Cell
Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line.
Lymphoma, B-Cell
Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion.
Lymphoma, B-Cell
Apatinib suppresses the Proliferation and Apoptosis of Gastric Cancer Cells via the PI3K/Akt Signaling Pathway.
Lymphoma, B-Cell
Apoptosis in human compressive myelopathy due to metastatic neoplasia.
Lymphoma, B-Cell
Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway.
Lymphoma, B-Cell
Are GLP-1 receptor agonists useful against traumatic brain injury?
Lymphoma, B-Cell
Arsenic trioxide induces apoptosis in the THP1 cell line by downregulating EVI-1.
Lymphoma, B-Cell
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.
Lymphoma, B-Cell
AXIN1 protects against testicular germ cell tumors via the PI3K/AKT/mTOR signaling pathway.
Lymphoma, B-Cell
Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling.
Lymphoma, B-Cell
Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity.
Lymphoma, B-Cell
CB2R induces a protective response for epileptic seizure via the PI3K 110?-AKT signaling pathway.
Lymphoma, B-Cell
Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing
Lymphoma, B-Cell
Characterization of the novel indolylmaleimides' PDA-66 and PDA-377 effect on canine lymphoma cells.
Lymphoma, B-Cell
Chronic type-I diabetes could not impede the anti-inflammatory and anti-apoptotic effects of combined postconditioning with ischemia and cyclosporine A in myocardial reperfusion injury.
Lymphoma, B-Cell
Cinobufagin Induces Cell Cycle Arrest at the G2/M Phase and Promotes Apoptosis in Malignant Melanoma Cells.
Lymphoma, B-Cell
Circadian rhythm genes in cancer: insight into their functions and regulation involving noncoding RNAs.
Lymphoma, B-Cell
Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1/PD-L1 axis activating intracellular AKT/mTOR pathway in tumor cells.
Lymphoma, B-Cell
Colony stimulating factor-1 receptor promotes proliferation, migration and invasion in the human nasopharyngeal carcinoma 6-10B cell line via the phosphoinositide 3-kinase/Akt pathway.
Lymphoma, B-Cell
Comparison of ataxia-telangiectasia mutated protein expression in diffuse large B-cell lymphomas of primary central nervous system and non-central nervous system origin.
Lymphoma, B-Cell
Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells.
Lymphoma, B-Cell
CX-4945, a selective inhibitor of casein kinase 2, synergizes with B cell receptor signaling inhibitors in inducing diffuse large B cell lymphoma cell death.
Lymphoma, B-Cell
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene.
Lymphoma, B-Cell
Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice.
Lymphoma, B-Cell
Dietary supplementation with free methionine or methionine dipeptide improves environment intestinal of broilers challenged with Eimeria spp.
Lymphoma, B-Cell
Dietary vitamin C deficiency depressed the gill physical barriers and immune barriers referring to Nrf2, apoptosis, MLCK, NF-?B and TOR signaling in grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare.
Lymphoma, B-Cell
Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-SY5Y cells.
Lymphoma, B-Cell
Dihydroartemisinin-induced apoptosis in human acute monocytic leukemia cells.
Lymphoma, B-Cell
Does the BCL-2 family member BIK control lung carcinogenesis?
Lymphoma, B-Cell
Edaravone Improves Intermittent Hypoxia-Induced Cognitive Impairment and Hippocampal Damage in Rats.
Lymphoma, B-Cell
Effect of Chrysanthemum zawadskii Extract on Dermal Papilla Cell Proliferation and Hair Growth.
Lymphoma, B-Cell
Effects of acute and chronic treatment elicited by lamotrigine on behavior, energy metabolism, neurotrophins and signaling cascades in rats.
Lymphoma, B-Cell
Effects of CDC7 gene silencing and Rituximab on apoptosis in diffuse large B cell lymphoma cells.
Lymphoma, B-Cell
Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure.
Lymphoma, B-Cell
ERK and p38 upregulation versus Bcl-6 downregulation in rat kidney epithelial cells exposed to prolonged hypoxia.
Lymphoma, B-Cell
Estrogen Receptor-? Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma.
Lymphoma, B-Cell
Expression and significance of leptin receptor, p-STAT3 and p-AKT in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Expression of glucose transporter-1, hypoxia-inducible factor-1?, phosphatidylinositol 3-kinase and protein kinase B (Akt) in relation to [(18)F]fluorodeoxyglucose uptake in nasopharyngeal diffuse large B-cell lymphoma: a case report and literature review.
Lymphoma, B-Cell
Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases.
Lymphoma, B-Cell
Ganetespib: research and clinical development.
Lymphoma, B-Cell
Germacrone protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy processes in PC12 cells.
Lymphoma, B-Cell
Ginkgetin aglycone attenuates neuroinflammation and neuronal injury in the rats with ischemic stroke by modulating STAT3/JAK2/SIRT1.
Lymphoma, B-Cell
Graphene Oxide Induces Apoptotic Cell Death in Endothelial Cells by Activating Autophagy via Calcium-dependent Phosphorylation of c-Jun N-terminal kinases.
Lymphoma, B-Cell
Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.
Lymphoma, B-Cell
High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy.
Lymphoma, B-Cell
Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses.
Lymphoma, B-Cell
Hypoglycemic Effect of Acidic Polysaccharide from Schisandra chinensis on T2D Rats Induced by High-Fat Diet Combined with STZ.
Lymphoma, B-Cell
Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.
Lymphoma, B-Cell
Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3.
Lymphoma, B-Cell
Investigation of Olea ferruginea Roylebark extracts for potential in vitroantidiabetic and anticancer effects.
Lymphoma, B-Cell
Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells.
Lymphoma, B-Cell
Knockdown of lncRNA-HOTAIR downregulates the drug-resistance of breast cancer cells to doxorubicin via the PI3K/AKT/mTOR signaling pathway.
Lymphoma, B-Cell
Light-emitting diode irradiation induces AKT/mTOR-mediated apoptosis in human pancreatic cancer cells and xenograft mouse model.
Lymphoma, B-Cell
Lupalbigenin from Derris scandens Sensitizes Detachment-induced Cell Death in Human Lung Cancer Cells.
Lymphoma, B-Cell
Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats.
Lymphoma, B-Cell
Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer.
Lymphoma, B-Cell
Melatonin attenuates cisplatin-induced acute kidney injury in rats via induction of anti-aging protein, Klotho.
Lymphoma, B-Cell
Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood-brain barrier integrity.
Lymphoma, B-Cell
Metformin reduces pancreatic cancer cell proliferation and increases apoptosis through MTOR signaling pathway and its dose-effect relationship.
Lymphoma, B-Cell
Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma.
Lymphoma, B-Cell
MMP-1 is overexpressed in triple-negative breast cancer tissues and the knockdown of MMP-1 expression inhibits tumor cell malignant behaviors in vitro.
Lymphoma, B-Cell
MOP-dependent enhancement of methadone on the effectiveness of ALA-PDT for A172 cells by upregulating phosphorylated JNK and BCL2.
Lymphoma, B-Cell
Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma.
Lymphoma, B-Cell
Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens.
Lymphoma, B-Cell
Nek2 is a novel regulator of B cell development and immunological response.
Lymphoma, B-Cell
NEK2 Promotes Cell Proliferation and Glycolysis by Regulating PKM2 Abundance via Phosphorylation in Diffuse Large B-Cell Lymphoma.
Lymphoma, B-Cell
Neonatal hyperglycemia induces cell death in the rat brain.
Lymphoma, B-Cell
NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway.
Lymphoma, B-Cell
Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects.
Lymphoma, B-Cell
Oxycodone inhibits myocardial cell apoptosis after myocardial ischemia-reperfusion injury in rats via RhoA/ROCK1 signaling pathway.
Lymphoma, B-Cell
Paired box gene 5 may modulate Proviral Integration of Moloney virus2gene and protein expression in mature B-cells.
Lymphoma, B-Cell
Paricalcitol attenuates indoxyl sulfate-induced apoptosis through the inhibition of MAPK, Akt, and NF-kB activation in HK-2 cells.
Lymphoma, B-Cell
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Lymphoma, B-Cell
PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.
Lymphoma, B-Cell
Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/vincristine in Relapsed/refractory Aggressive B-cell Lymphoma.
Lymphoma, B-Cell
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Lymphoma, B-Cell
PI3K/Akt Signaling Pathway Ameliorates Oxidative Stress-Induced Apoptosis upon Manganese Exposure in PC12 Cells.
Lymphoma, B-Cell
PI3K/Akt signaling pathway and Hsp70 activate in hippocampus of rats with chronic manganese sulfate exposure.
Lymphoma, B-Cell
Polydeoxyribonucleotide Ameliorates Inflammation and Apoptosis in Achilles Tendon-Injury Rats.
Lymphoma, B-Cell
Potential mechanisms of action of lithium in bipolar disorder. Current understanding.
Lymphoma, B-Cell
Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
Lymphoma, B-Cell
Protective Effect of Polydeoxyribonucleotide Against Renal Ischemia-Reperfusion Injury in Mice.
Lymphoma, B-Cell
Protective effect of vascular endothelial growth factor against cardiopulmonary bypass-associated acute kidney injury in beagles.
Lymphoma, B-Cell
Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth.
Lymphoma, B-Cell
Puerarin induces cell apoptosis in human chondrosarcoma cell line SW1353 via inhibition of the PI3K/Akt signaling pathway.
Lymphoma, B-Cell
PVT1 Mediates Cell Proliferation, Apoptosis and Radioresistance in Nasopharyngeal Carcinoma Through Regulating miR-515-5p/PIK3CA Axis.
Lymphoma, B-Cell
Quantitative mRNA expression analysis of selected genes in patients with early-stage hypothyroidism induced by treatment with iodine-131.
Lymphoma, B-Cell
Quercetin prevents alcohol-induced liver injury through targeting of PI3K/Akt/nuclear factor-?B and STAT3 signaling pathway.
Lymphoma, B-Cell
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Lymphoma, B-Cell
Reverse translational strategies for developing animal models of bipolar disorder.
Lymphoma, B-Cell
ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis.
Lymphoma, B-Cell
Rosiglitazone improves learning and memory ability in rats with type 2 diabetes through the insulin signaling pathway.
Lymphoma, B-Cell
Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.
Lymphoma, B-Cell
RyRs mediate lead-induced neurodegenerative disorders through calcium signaling pathways.
Lymphoma, B-Cell
Sensitisation of c-MYC-induced B-lymphoma cells to apoptosis by ATF2.
Lymphoma, B-Cell
Silencing of RHEB inhibits cell proliferation and promotes apoptosis in colorectal cancer cells via inhibition of the mTOR signaling pathway.
Lymphoma, B-Cell
Sinomenine can promote the proliferation and differentiation of osteoblasts by regulating the Akt/Runx2 signaling pathway in MC3T3-E1 cells.
Lymphoma, B-Cell
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
St. John's Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway.
Lymphoma, B-Cell
STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma.
Lymphoma, B-Cell
Streptozotocin-Induced Autophagy Reduces Intracellular Insulin in Insulinoma INS-1E Cells.
Lymphoma, B-Cell
Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis.
Lymphoma, B-Cell
Targeting beta2-microglobulin mediated signaling as a novel therapeutic approach for human renal cell carcinoma.
Lymphoma, B-Cell
The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain.
Lymphoma, B-Cell
The Coffee Diterpene, Kahweol, Ameliorates Pancreatic ?-Cell Function in Streptozotocin (STZ)-Treated Rat INS-1 Cells through NF-kB and p-AKT/Bcl-2 Pathways.
Lymphoma, B-Cell
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Lymphoma, B-Cell
The impact of activated p-AKT expression on clinical outcomes in diffuse large B-cell lymphoma: a clinicopathological study of 262 cases.
Lymphoma, B-Cell
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Lymphoma, B-Cell
The neurotrophic and neuroprotective effects of psychotropic agents.
Lymphoma, B-Cell
The protective effects of exogenous spermine on renal ischemia-reperfusion injury in rats.
Lymphoma, B-Cell
The role of E3 ubiquitin ligase Cbl proteins in interleukin-2-induced Jurkat T-cell activation.
Lymphoma, B-Cell
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Lymphoma, B-Cell
Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells.
Lymphoma, B-Cell
Tumor necrosis factor ? sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner.
Lymphoma, B-Cell
Ulinastatin inhibits high glucose-induced cardiomyocyte apoptosis through activating Akt signaling.
Lymphoma, B-Cell
[Effects of AKT protein kinase activation on biologic behavior of diffuse large B cell lymphoma cells]
Lymphoma, B-Cell
[Effects of AS1411 on the apoptosis of taxol-resistant lung adenocarcinoma A549 cell].
Lymphoma, B-Cell, Marginal Zone
Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-?B and JNK activation.
Lymphoma, Follicular
DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.
Lymphoma, Follicular
Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens.
Lymphoma, Follicular
Phase I/II study of dasatinib and exploratory genomic analysis in relapsed or refractory non-Hodgkin lymphoma.
Lymphoma, Follicular
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Lymphoma, Follicular
PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma.
Lymphoma, Large B-Cell, Diffuse
Cellular resistance to vincristine suppresses NF-kappa B activation and apoptosis but enhances c-Jun-NH2-terminal protein kinase activation by tumor necrosis.
Lymphoma, Large B-Cell, Diffuse
Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1/PD-L1 axis activating intracellular AKT/mTOR pathway in tumor cells.
Lymphoma, Large B-Cell, Diffuse
CX-4945, a selective inhibitor of casein kinase 2, synergizes with B cell receptor signaling inhibitors in inducing diffuse large B cell lymphoma cell death.
Lymphoma, Large B-Cell, Diffuse
Effects of CDC7 gene silencing and Rituximab on apoptosis in diffuse large B cell lymphoma cells.
Lymphoma, Large B-Cell, Diffuse
Expression and significance of leptin receptor, p-STAT3 and p-AKT in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Expression of glucose transporter-1, hypoxia-inducible factor-1?, phosphatidylinositol 3-kinase and protein kinase B (Akt) in relation to [(18)F]fluorodeoxyglucose uptake in nasopharyngeal diffuse large B-cell lymphoma: a case report and literature review.
Lymphoma, Large B-Cell, Diffuse
High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy.
Lymphoma, Large B-Cell, Diffuse
Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3.
Lymphoma, Large B-Cell, Diffuse
Nek2 is a novel regulator of B cell development and immunological response.
Lymphoma, Large B-Cell, Diffuse
NEK2 Promotes Cell Proliferation and Glycolysis by Regulating PKM2 Abundance via Phosphorylation in Diffuse Large B-Cell Lymphoma.
Lymphoma, Large B-Cell, Diffuse
NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells.
Lymphoma, Large B-Cell, Diffuse
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
The impact of activated p-AKT expression on clinical outcomes in diffuse large B-cell lymphoma: a clinicopathological study of 262 cases.
Lymphoma, Large B-Cell, Diffuse
[Effects of AKT protein kinase activation on biologic behavior of diffuse large B cell lymphoma cells]
Lymphoma, Large-Cell, Anaplastic
CD30 Induces Heat Shock Protein 90 and Signal Integration in Classic Hodgkin Lymphoma Cells.
Lymphoma, Large-Cell, Anaplastic
Epigenetic changes in the DAP-kinase CpG island in pediatric lymphoma.
Lymphoma, Large-Cell, Anaplastic
Identification of a novel crosstalk between casein kinase 2? and NPM-ALK in ALK-positive anaplastic large cell lymphoma.
Lymphoma, Large-Cell, Anaplastic
[Study on activation of AKT/mTOR pathway in anaplastic large cell lymphoma]
Lymphoma, Mantle-Cell
Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2.
Lymphoma, Mantle-Cell
Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Lymphoma, Mantle-Cell
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
Lymphoma, Mantle-Cell
Biological and clinical significance of GSK-3beta in mantle cell lymphoma--an immunohistochemical study.
Lymphoma, Mantle-Cell
CD5(-) diffuse large B-cell lymphoma with peculiar cyclin D1+ phenotype. Pathologic and molecular characterization of a single case.
Lymphoma, Mantle-Cell
Familial lymphoid neoplasms in patients with mantle cell lymphoma Familial lymphoid neoplasms in patients with mantle cell lymphoma.
Lymphoma, Mantle-Cell
GSK-3beta inhibition: at the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma.
Lymphoma, Mantle-Cell
Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.
Lymphoma, Mantle-Cell
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
Lymphoma, Mantle-Cell
Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma.
Lymphoma, Mantle-Cell
Protein Kinase CK2 Inhibition Down Modulates the NF-?B and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells.
Lymphoma, Mantle-Cell
Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth.
Lymphoma, Mantle-Cell
RAF-1 over-expression does condition survival of patients affected by aggressive mantle cell lymphoma.
Lymphoma, Mantle-Cell
Serine-227 in the N-terminal kinase domain of RSK2 is a potential therapeutic target for mantle cell lymphoma.
Lymphoma, Mantle-Cell
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Lymphoma, Mantle-Cell
The PARP inhibitor olaparib induces significant killing of ATM deficient lymphoid tumour cells in vitro and in vivo.
Lymphoma, Non-Hodgkin
A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
Aurora A inhibitor (MLN8237) plus Vincristine synergizes with Rituximab as a potential curative therapy in aggressive B-cell non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas.
Lymphoma, Non-Hodgkin
Correction: Aurora A Inhibitor (MLN8237) plus Vincristine plus Rituximab Is Synthetic Lethal and a Potential Curative Therapy in Aggressive B-cell Non-Hodgkin Lymphoma.
Lymphoma, Non-Hodgkin
Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
Effect of dexamethasone on nucleolar casein kinase II activity and phosphorylation of nucleolin in lymphosarcoma P1798 cells.
Lymphoma, Non-Hodgkin
Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies.
Lymphoma, Non-Hodgkin
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.
Lymphoma, Non-Hodgkin
Non-canonical NF-?B Plays a Pivotal Role in Non-Hodgkin's Lymphoma.
Lymphoma, Non-Hodgkin
Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Lymphoma, Non-Hodgkin
Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/vincristine in Relapsed/refractory Aggressive B-cell Lymphoma.
Lymphoma, Non-Hodgkin
Resolution and characterization of calcium/phospholipid-dependent protein kinase and H4 protease-activated protein kinase activities in lymphoid cells.
Lymphoma, Non-Hodgkin
Serine-227 in the N-terminal kinase domain of RSK2 is a potential therapeutic target for mantle cell lymphoma.
Lymphoma, Non-Hodgkin
Transforming growth factor beta type II receptor (TGF beta RII) mutation in gastric lymphoma without mutator phenotype.
Lymphoma, Primary Effusion
Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation.
Lymphoma, Primary Effusion
Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen.
Lymphoma, Primary Effusion
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta.
Lymphoma, T-Cell
13-methyltetradecanoic acid exhibits anti-tumor activity on T-cell lymphomas in vitro and in vivo by down-regulating p-AKT and activating caspase-3.
Lymphoma, T-Cell
Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.
Lymphoma, T-Cell
Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts.
Lymphoma, T-Cell
Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment.
Lymphoma, T-Cell
Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma.
Lymphoma, T-Cell
Dihydroartemisinin triggers c-Myc proteolysis and inhibits protein kinase B/glycogen synthase kinase 3? pathway in T-cell lymphoma cells.
Lymphoma, T-Cell
GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity.
Lymphoma, T-Cell
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.
Lymphoma, T-Cell
Pim-1 activation of cell motility induces the malignant phenotype of tongue carcinoma.
Lymphoma, T-Cell
Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.
Lymphoma, T-Cell
Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma.
Lymphoma, T-Cell
Structure of a Moloney murine leukemia virus-virus-like 30 recombinant: implications for transduction of the c-Ha-ras proto-oncogene.
Lymphoma, T-Cell, Peripheral
Randomized Phase III Study of Alisertib or Investigator's Choice (Selected Single Agent) in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma.
Lymphoma, T-Cell, Peripheral
The clinical significance of activated p-AKT expression in peripheral T-cell lymphoma.
Lymphopenia
A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient.
Lymphopenia
EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency.
Lymphoproliferative Disorders
Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease.
Lymphoproliferative Disorders
The role of aurora A and polo-like kinases in high-risk lymphomas.
Machado-Joseph Disease
CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.
Macular Degeneration
17?-estradiol ameliorates oxidative stress and blue light-emitting diode-induced retinal degeneration by decreasing apoptosis and enhancing autophagy.
Macular Degeneration
Insensitivity of PI3K/Akt/GSK3 signaling in peripheral blood mononuclear cells of age-related macular degeneration patients.
Macular Edema
The role of Raf-1 kinase in diabetic retinopathy.
Malaria
A Plasmodium berghei putative serine-threonine kinase 2 (PBANKA_0311400) is required for late liver stage development and timely initiation of blood stage infection.
Malaria
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
Malaria
Biophysical characterization of the calmodulin-like domain of Plasmodium falciparum calcium dependent protein kinase 3.
Malaria
Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite.
Malaria
Dematin, a component of the erythrocyte membrane skeleton, is internalized by the malaria parasite and associates with Plasmodium 14-3-3.
Malaria
Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.
Malaria
Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors.
Malaria
Expression, purification and biochemical characterization of recombinant Ca-dependent protein kinase 2 of the malaria parasite Plasmodium falciparum.
Malaria
FIKK Kinase, a Ser/Thr Kinase Important to Malaria Parasites, Is Inhibited by Tyrosine Kinase Inhibitors.
Malaria
Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum.
Malaria
Generation and evaluation of a homology model of PfGSK-3.
Malaria
Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking.
Malaria
High levels of IgE autoantibody to 14-3-3 epsilon protein correlate with protection against severe Plasmodium falciparum malaria.
Malaria
Identification, cloning, and mutational analysis of the casein kinase 1 cDNA of the malaria parasite, Plasmodium falciparum. Stage-specific expression of the gene.
Malaria
In silico analysis of plasmodium falciparum CDPK5 protein through molecular modeling, docking and dynamics.
Malaria
Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome.
Malaria
Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1.
Malaria
Malaria Protein Kinase CK2 (PfCK2) Shows Novel Mechanisms of Regulation.
Malaria
Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite.
Malaria
Selective inhibitors of Plasmodium falciparum glycogen synthase-3 (PfGSK-3): New antimalarial agents?
Malaria
Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum.
Malaria
The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition.
Malaria
The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism.
Malaria
Topological polar surface area: a useful descriptor in 2D-QSAR.
Malaria, Falciparum
High levels of IgE autoantibody to 14-3-3 epsilon protein correlate with protection against severe Plasmodium falciparum malaria.
Malformations of Cortical Development
Pathological tau tangles localize to focal cortical dysplasia in older patients.
Malnutrition
Effect of restricted food intake on production, catabolism, and effects of IGF-I and cyclic nucleotides in cultured ovarian tissue of domestic nutria (Myocastor coypus).
Malnutrition
Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition.
Malnutrition
Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis.
Mammary Neoplasms, Animal
Expression of 14-3-3 ? protein in normal and neoplastic canine mammary gland.
Mania
Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.
Mania
Forebrain-specific ablation of phospholipase C?1 causes manic-like behavior.
Mania
Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application.
Mania
Hyperactivity and enhanced curiosity of mice expressing PKB/SGK-resistant glycogen synthase kinase-3 (GSK-3).
Mania
Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and In Vivo Activity in a Mood Disorder Model.
Mania
Regulation of glycogen synthase kinase-3 during bipolar mania treatment.
Mania
Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.
Mania
Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania.
Mania
Why is lithium effective in alleviating bipolar disorder?
Marek Disease
Role of Marek's Disease Virus (MDV)-Encoded US3 Serine/Threonine Protein Kinase in Regulating MDV Meq and Cellular CREB Phosphorylation.
Marfan Syndrome
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Marfan Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Mastitis
Acremonium terricola culture plays anti-inflammatory and antioxidant roles by modulating MAPK signaling pathways in rats with lipopolysaccharide-induced mastitis.
Mastitis
Farrerol Relieve Lipopolysaccharide (LPS)-Induced Mastitis by Inhibiting AKT/NF-?B p65, ERK1/2 and P38 Signaling Pathway.
Mastitis
Genome-Wide Association Study for Susceptibility to and Recoverability From Mastitis in Danish Holstein Cows.
Mastocytoma
Changes in cyclic AMP-dependent protein kinases during inhibition of mastocytoma cell growth by dibutyryl cyclic AMP.
Mastocytoma
Enhanced anti-proliferative effects of combinatorial treatment of delta-tocopherol and resveratrol in human HMC-1 cells.
Mastocytoma
Regulation of topoisomerase II by murine mastocytoma cells.
Measles
Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy.
Measles
Involvement of cellular casein kinase II in the phosphorylation of measles virus P protein: identification of phosphorylation sites.
Measles
Optimising measles virus-guided radiovirotherapy with external beam radiotherapy and specific checkpoint kinase 1 inhibition.
Measles
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling.
Measles
Viral strategies for triggering and manipulating mitophagy.
Medulloblastoma
Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide.
Medulloblastoma
Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity.
Medulloblastoma
Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma.
Medulloblastoma
Control of beta-catenin/Tcf-directed transcription in medulloblastoma.
Medulloblastoma
Correction: Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide.
Medulloblastoma
GSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma.
Medulloblastoma
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Medulloblastoma
Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3beta constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines.
Medulloblastoma
Lithium induces mortality in medulloblastoma cell lines.
Medulloblastoma
Overcoming resistance to sonic hedgehog inhibition by targeting p90 ribosomal S6 kinase in pediatric medulloblastoma.
Medulloblastoma
Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN.
Medulloblastoma
Protein kinase A regulatory subunit distribution in medulloblastoma.
Medulloblastoma
Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth.
Medulloblastoma
Sporadic medulloblastomas contain oncogenic beta-catenin mutations.
Medulloblastoma
Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.
Medulloblastoma
The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma.
Megalencephaly
A de novo mutation in the X-linked PAK3 gene is the underlying cause of intellectual disability and macrocephaly in monozygotic twins.
Megalencephaly
Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity.
Megalencephaly
Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Megalencephaly
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Melanoma
1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation.
Melanoma
6-Bromoindirubin-3'oxime (BIO) decreases proliferation and migration of canine melanoma cell lines.
Melanoma
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.
Melanoma
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib.
Melanoma
A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma.
Melanoma
A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors.
Melanoma
A phase 2 study of glembatumumab vedotin, an antibody-drug conjugate targeting glycoprotein NMB, in patients with advanced melanoma.
Melanoma
A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status.
Melanoma
A Transcriptome-Wide Isoform Landscape of Melanocytic Nevi and Primary Melanomas Identifies Gene Isoforms Associated with Malignancy.
Melanoma
A(nother) RAF mutation in LCH.
Melanoma
A3 adenosine receptor activation in melanoma cells: association between receptor fate and tumor growth inhibition.
Melanoma
Absence of mutations in the pleckstrin homology (PH) domain of protein kinase B (PKB/Akt) in malignant melanoma.
Melanoma
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Melanoma
Acquisition of resistance to vemurafenib leads to interleukin-10 production through an aberrant activation of Akt in a melanoma cell line.
Melanoma
Acriflavine, a Potent Inhibitor of HIF-1?, Disturbs Glucose Metabolism and Suppresses ATF4-Protective Pathways in Melanoma under Non-Hypoxic Conditions.
Melanoma
Activation of c-jun N-terminal kinase is associated with cell proliferation and shorter relapse-free period in superficial spreading malignant melanoma.
Melanoma
Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells.
Melanoma
Activation of cGMP-Dependent Protein Kinase Restricts Melanoma Growth and Invasion by Interfering with the EGF/EGFR Pathway.
Melanoma
Activation of the AKT and mammalian target of rapamycin pathways and the inhibitory effects of rapamycin on those pathways in canine malignant melanoma cell lines.
Melanoma
Activation of Wnt/?-catenin signaling increases apoptosis in melanoma cells treated with trail.
Melanoma
Alisertib promotes apoptosis and autophagy in melanoma through p38 MAPK-mediated aurora a signaling.
Melanoma
Alleviation of LPS-Induced Inflammation and Septic Shock by Lactiplantibacillus plantarum K8 Lysates.
Melanoma
alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells.
Melanoma
Alterations in the expression of MHC class I glycoproteins by B16BL6 melanoma cells modulate insulin receptor-regulated signal transduction and augment [correction of augments] resistance to apoptosis.
Melanoma
An automated image capture and quantitation approach to identify proteins affecting tumor cell proliferation.
Melanoma
An extract of Melia toosendan attenuates endothelin-1-stimulated pigmentation in human epidermal equivalents through the interruption of PKC activity within melanocytes.
Melanoma
An Extract of Withania somnifera Attenuates Endothelin-1-stimulated Pigmentation in Human Epidermal Equivalents through the Interruption of PKC Activity Within Melanocytes.
Melanoma
An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.
Melanoma
Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion.
Melanoma
Anticancer effects of combinational treatment with BRAFV600E siRNA and PI3K pathway inhibitors in melanoma cell lines harboring BRAFV600E.
Melanoma
Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.
Melanoma
ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis.
Melanoma
Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers.
Melanoma
B-raf exon 15 mutations are common in primary melanoma resection specimens but not associated with clinical outcome.
Melanoma
B-RAF inhibitors: an evolving role in the therapy of malignant melanoma.
Melanoma
B-RAF is a therapeutic target in melanoma.
Melanoma
Bacterial type III effector protein HopQ inhibits melanoma motility through autophagic degradation of vimentin.
Melanoma
BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition.
Melanoma
Bench to bedside: mechanistic principles of targeting the RAF kinase in melanoma.
Melanoma
Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance.
Melanoma
Biophysical characterization of melanoma cell phenotype markers during metastatic progression.
Melanoma
BRAF and endocrine tumors: mutations are frequent in papillary thyroid carcinomas, rare in endocrine tumors of the gastrointestinal tract and not detected in other endocrine tumors.
Melanoma
BRAF inhibition causes resilience of melanoma cell lines by inducing the secretion of FGF1.
Melanoma
BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis.
Melanoma
BRAF inhibitors: resistance and the promise of combination treatments for melanoma.
Melanoma
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.
Melanoma
BRAF V600 mutation detection in melanoma: a comparison of two laboratory testing methods.
Melanoma
BRAF, a target in melanoma: implications for solid tumor drug development.
Melanoma
Cancer drug addiction is relayed by an ERK2-dependent phenotype switch.
Melanoma
Casein kinase 1? has a non-redundant and dominant role within the CK1 family in melanoma progression.
Melanoma
CD133? melanoma subpopulation acquired resistance to caffeic acid phenethyl ester-induced apoptosis is attributed to the elevated expression of ABCB5: significance for melanoma treatment.
Melanoma
Cdc7 expression in melanomas, Spitz tumors and melanocytic nevi.
Melanoma
Cell-type-specific Modulation of Non-homologous End Joining of Gamma Ray-induced DNA Double-strand Breaks by cAMP Signaling in Human Cancer Cells.
Melanoma
Cellular pathways leading to melanoma differentiation: therapeutic implications.
Melanoma
Cepharanthine exerts antitumor activity on choroidal melanoma by reactive oxygen species production and c-Jun N-terminal kinase activation.
Melanoma
Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor ?2.
Melanoma
Circular RNA has circ 0001591 promoted cell proliferation and metastasis of human melanoma via ROCK1/PI3K/AKT by targeting miR-431-5p.
Melanoma
Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
Melanoma
Cobimetinib: inhibiting MEK1/2 in BRAF V600-mutant melanoma.
Melanoma
Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma.
Melanoma
Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first-line therapy for BRAF-mutated metastatic melanoma.
Melanoma
Complex Formation Between S100B and the p90 Ribosomal S6 Kinase (RSK) in Malignant Melanoma is Ca2+-dependent and inhibits ERK-mediated Phosphorylation of RSK.
Melanoma
Computational algorithms for in silico profiling of activating mutations in cancer.
Melanoma
Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.
Melanoma
Cordycepin (3'-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression.
Melanoma
Costunolide suppresses melanoma growth via the AKT/mTOR pathway in vitro and in vivo.
Melanoma
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
Melanoma
Coupling of mitochondria to store-operated Ca(2+)-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells.
Melanoma
CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma.
Melanoma
Curcumol inhibits the proliferation and metastasis of melanoma via the miR-152-3p/PI3K/AKT and ERK/NF-?B signaling pathways.
Melanoma
Dabrafenib in the treatment of advanced melanoma.
Melanoma
Data on left ventricular expression of STAT3 and AKT in transgenic mouse models with B16F10 melanoma.
Melanoma
Decoding the Role of CD271 in Melanoma.
Melanoma
Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes.
Melanoma
Design, synthesis and biological evaluation of novel (E)-?-benzylsulfonyl chalcone derivatives as potential BRAF inhibitors.
Melanoma
Determinants of BRAF mutations in primary melanomas.
Melanoma
Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients.
Melanoma
Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying vemurafenib in human plasma.
Melanoma
Development of a novel chemical class of BRAF inhibitors offers new hope for melanoma treatment.
Melanoma
Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization.
Melanoma
Development of [11C]vemurafenib employing a carbon-11 carbonylative Stille coupling and preliminary evaluation in mice bearing melanoma tumor xenografts.
Melanoma
Differential effects of phosphorylation on DNA binding properties of N Oct-3 are dictated by protein/DNA complex structures.
Melanoma
Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell lines.
Melanoma
Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.
Melanoma
Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure.
Melanoma
DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion.
Melanoma
Dual c-Jun N-terminal kinase-cyclin D1 and extracellular signal-related kinase-c-Jun disjunction in human melanoma.
Melanoma
Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer.
Melanoma
Emerging views of mitophagy in immunity and autoimmune diseases.
Melanoma
Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.
Melanoma
Enhanced casein kinase II activity in metastatic melanoma.
Melanoma
EPAC-RAP1 Axis-mediated Switch in the Response of Primary and Metastatic Melanoma to cyclic AMP.
Melanoma
ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa.
Melanoma
Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.
Melanoma
Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells.
Melanoma
Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome.
Melanoma
Expression of activated Akt in benign nevi, Spitz nevi and melanomas.
Melanoma
Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas).
Melanoma
Expression of Raf Kinase Inhibitor Protein (RKIP) is a predictor of uveal melanoma metastasis.
Melanoma
Expression of type A and B tumor necrosis factor (TNF) receptors on melanoma cells can be regulated by dbc-AMP and IFN gamma.
Melanoma
Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness.
Melanoma
Fertility preservation and management of pregnancy in melanoma patients requiring systemic therapy.
Melanoma
Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells.
Melanoma
Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NF?B Signaling Pathways.
Melanoma
Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models.
Melanoma
Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland.
Melanoma
FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells.
Melanoma
Genetic alterations in signaling pathways in melanoma.
Melanoma
GSK-3 Promotes Cell Survival, Growth, and PAX3 Levels in Human Melanoma Cells.
Melanoma
GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines.
Melanoma
GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes.
Melanoma
Heavily Pigmented Epithelioid Melanoma With Loss of Protein Kinase A Regulatory Subunit-? Expression.
Melanoma
HER3-Receptor-Mediated STAT3 Activation Plays a Central Role in Adaptive Resistance toward Vemurafenib in Melanoma.
Melanoma
High cytotoxic T-lymphocyte-associated antigen 4 and phospho-Akt expression in tumor samples predicts poor clinical outcomes in ipilimumab-treated melanoma patients.
Melanoma
High lithium levels in tobacco may account for reduced incidences of both Parkinson's disease and melanoma in smokers through enhanced ?-catenin-mediated activity.
Melanoma
Histamine inhibits the production of interferon-induced protein of 10 kDa in human squamous cell carcinoma and melanoma.
Melanoma
Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity.
Melanoma
Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.
Melanoma
How to make a melanoma: what do we know of the primary clonal events?
Melanoma
Human malignant melanoma: detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis.
Melanoma
Human melanoma cells resistant to MAPK inhibitors can be effectively targeted by inhibition of the p90 ribosomal S6 kinase.
Melanoma
Human sulfatase 1 exerts anti-tumor activity by inhibiting the AKT/ CDK4 signaling pathway in melanoma.
Melanoma
Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells.
Melanoma
Implication of integrin ?2?1 in anoikis of SK-Mel-147 human melanoma cells: a non-canonical function of Akt protein kinase.
Melanoma
Implication of Integrin ?2?1 in Proliferation and Invasion of Human Breast Carcinoma and Melanoma Cells: Noncanonical Function of Akt Protein Kinase.
Melanoma
Implication of integrins ?3?1 and ?5?1 in invasion and anoikis of SK-Mel-147 human melanoma cells: non-canonical functions of protein kinase Akt.
Melanoma
Improved survival with MEK inhibition in BRAF-mutated melanoma.
Melanoma
Improving classification of melanocytic nevi: Association of BRAF V600E expression with distinct histomorphologic features.
Melanoma
Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma.
Melanoma
Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation.
Melanoma
Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells.
Melanoma
Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis.
Melanoma
Inhibition of DNA-PKcs activity re-sensitizes uveal melanoma cells to radio- and chemotherapy.
Melanoma
Inhibition of mutated, activated BRAF in metastatic melanoma.
Melanoma
Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells.
Melanoma
Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing.
Melanoma
Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues.
Melanoma
Involvement of HIF-1 in invasion of Mum2B uveal melanoma cells.
Melanoma
Kinase signaling pathways as targets for intervention in pancreatic cancer.
Melanoma
Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth.
Melanoma
LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.
Melanoma
LncRNA HAND2-AS1 overexpression inhibits cancer cell proliferation in melanoma by downregulating ROCK1.
Melanoma
Long-term Survival of Stage IV Melanoma Patients Treated with BOLD Combination Chemotherapy and Intermediate-dose Subcutaneous Interferon-alpha.
Melanoma
Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.
Melanoma
Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions.
Melanoma
Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
Melanoma
Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2.
Melanoma
Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies.
Melanoma
Lymph node metastases of melanoma: challenges for BRAF mutation detection.
Melanoma
MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation.
Melanoma
MAPK and Hippo signaling pathways crosstalk via the RAF-1/MST-2 interaction in malignant melanoma.
Melanoma
Mcl-1 is required for melanoma cell resistance to anoikis.
Melanoma
Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases.
Melanoma
Mechanisms of Resistance to Mitogen-Activated Protein Kinase Pathway Inhibition in BRAF-Mutant Melanoma.
Melanoma
MED27 promotes melanoma growth by targeting AKT/MAPK and NF-?B/iNOS signaling pathways.
Melanoma
Melanoma cells express elevated levels of phosphorylated histone H2AX foci.
Melanoma
Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance.
Melanoma
Melanoma metastases caught in the AKT.
Melanoma
Melanoma Single-Cell Biology in Experimental and Clinical Settings.
Melanoma
Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways.
Melanoma
Melanoma-expressed CD70 is involved in invasion and metastasis.
Melanoma
Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species.
Melanoma
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Melanoma
MicroRNA-15a inhibits the growth and invasiveness of malignant melanoma and directly targets on CDCA4 gene.
Melanoma
MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies.
Melanoma
miR-146a Exerts Differential Effects on Melanoma Growth and Metastatization.
Melanoma
MiR-30a-5p confers cisplatin resistance by regulating IGF1R expression in melanoma cells.
Melanoma
miR-335 Acts as a Tumor Suppressor and Enhances Ionizing Radiation-Induced Tumor Regression by Targeting ROCK1.
Melanoma
MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma.
Melanoma
miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma.
Melanoma
MiR-9-5p Inhibits the Proliferation, Migration and Invasion of Choroidal Melanoma by Targeting BRAF.
Melanoma
miRNA-7-5p inhibits melanoma cell migration and invasion.
Melanoma
Mitochondrial biogenesis meets chemoresistance in BRAF-mutant melanoma.
Melanoma
MMP2 expression is a prognostic marker for primary melanoma patients.
Melanoma
Molecular Profiling of Merkel Cell Polyomavirus-Associated Merkel Cell Carcinoma and Cutaneous Melanoma.
Melanoma
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Melanoma
Muc1 promotes migration and lung metastasis of melanoma cells.
Melanoma
Mutant B-RAF mediates resistance to anoikis via Bad and Bim.
Melanoma
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.
Melanoma
Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma.
Melanoma
Mutations in BRAF codons 594 and 596 predict good prognosis in melanoma.
Melanoma
Mutations of the activation-associated phosphorylation sites at codons 308 and 473 of protein kinase B are absent in human melanoma.
Melanoma
Mutations of the BRAF gene in human cancer.
Melanoma
NAMPT Over-Expression Recapitulates the BRAF Inhibitor Resistant Phenotype Plasticity in Melanoma.
Melanoma
NF-?B as potential target in the treatment of melanoma.
Melanoma
Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma.
Melanoma
Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors.
Melanoma
Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead.
Melanoma
Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold.
Melanoma
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.
Melanoma
NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.
Melanoma
Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells.
Melanoma
Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability.
Melanoma
Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma.
Melanoma
Opposite long-term regulation of c-Myc and p27Kip1 through overactivation of Raf-1 and the MEK/ERK module in proliferating human choroidal melanoma cells.
Melanoma
Outcomes of endoscopic ultrasound as a one-off pancreatic cancer screening tool for 122 high- and moderate-risk patients.
Melanoma
Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells.
Melanoma
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
Melanoma
Oxidative phosphorylation promotes primary melanoma invasion.
Melanoma
P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma.
Melanoma
Pathologic Characteristics of Spitz Melanoma With MAP3K8 Fusion or Truncation in a Pediatric Cohort.
Melanoma
Pembrolizumab for metastatic melanoma in a renal allograft recipient with subsequent graft rejection and treatment response failure: a case report.
Melanoma
Perturbation biology: inferring signaling networks in cellular systems.
Melanoma
Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.
Melanoma
Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.
Melanoma
Phosphoproteomics of MAPK inhibition in BRAF-mutated cells and a role for the lethal synergism of dual BRAF and CK2 inhibition.
Melanoma
Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation.
Melanoma
PIN1 facilitates ubiquitin-mediated degradation of serine/threonine kinase 3 and promotes melanoma development via TAZ activation.
Melanoma
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Melanoma
PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways.
Melanoma
Polymorphisms at site 469 of B-RAF protein associated with skin melanoma may be correlated with dabrafenib resistance: An in silico study.
Melanoma
Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP?2 and MMP?9 via downregulation of NF-?B signaling pathway.
Melanoma
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.
Melanoma
Potentially useful markers for desmoplastic melanoma: an analysis of KBA.62, p-AKT, and ezrin.
Melanoma
PP6C Hotspot Mutations in Melanoma Display Sensitivity to Aurora Kinase Inhibition.
Melanoma
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.
Melanoma
Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases.
Melanoma
Preponderance of the oncogenic V599E and V599K mutations in the B-raf kinase domain is enhanced in melanoma lymph node metastases.
Melanoma
Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade.
Melanoma
Prognostic relevance of ATM protein in uveal melanoma and its association with clinicopathological factors.
Melanoma
Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases.
Melanoma
Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway.
Melanoma
Protein expression of KIT, BRAF, GNA11, GNAQ and RASSF1 in feline diffuse iris melanomas.
Melanoma
Protein kinase activity is associated with CD63 in melanoma cells.
Melanoma
Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1.
Melanoma
Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling.
Melanoma
Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1.
Melanoma
Proteomic analysis and the antimetastatic effect of N-(4-methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-induced apoptosis in human melanoma SK-MEL-28 cells.
Melanoma
Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF).
Melanoma
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.
Melanoma
Raf kinase inhibitor protein (RKIP) and phospho-RKIP expression in melanomas.
Melanoma
Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.
Melanoma
Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.
Melanoma
Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines.
Melanoma
Response of experimental malignant melanoma models to the pan-Aurora kinase inhibitor VE-465.
Melanoma
Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells.
Melanoma
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Melanoma
RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells.
Melanoma
RNA-interference-mediated downregulation of Pin1 suppresses tumorigenicity of malignant melanoma A375 cells.
Melanoma
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions.
Melanoma
ROCK1 and ROCK2 Are Down-regulated in Aggressive and Advanced Skin Melanomas - A Clinicopathological Perspective.
Melanoma
ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma.
Melanoma
Role of activated protein kinase B in melanoma.
Melanoma
Role of c-Jun N-terminal kinase isoforms in the cellular activity of melanoma cell lines.
Melanoma
Role of p53 Up-regulated Modulator of Apoptosis and Phosphorylated Akt in Melanoma Cell Growth, Apoptosis, and Patient Survival.
Melanoma
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Melanoma
RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.
Melanoma
RSK1 Activation Promotes Invasion in Nodular Melanoma.
Melanoma
Serum 5-S-cysteinyl-dopa levels as a predictive marker for the efficacy of nivolumab in advanced malignant melanoma.
Melanoma
Silymarin Targets ?-Catenin Signaling in Blocking Migration/Invasion of Human Melanoma Cells.
Melanoma
Similar biological activities of two isostructural ruthenium and osmium complexes.
Melanoma
Small Molecule Inhibition of Glycogen Synthase Kinase-3 in Cancer Immunotherapy.
Melanoma
Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas.
Melanoma
STAT3-induced ZBED3-AS1 promotes the malignant phenotypes of melanoma cells by activating PI3K/AKT signaling pathway.
Melanoma
Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells.
Melanoma
Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation.
Melanoma
Suppression of BRAF(V599E) in human melanoma abrogates transformation.
Melanoma
Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis.
Melanoma
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.
Melanoma
Targeted molecular therapy in melanoma.
Melanoma
Targeting BRAF in multiple myeloma.
Melanoma
Targeting BRAF-Mutant Non-Small Cell Lung Cancer: From Molecular Profiling to Rationally Designed Therapy.
Melanoma
Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel.
Melanoma
Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases.
Melanoma
Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells.
Melanoma
Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression.
Melanoma
Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2.
Melanoma
Temporal activation of WNT/?-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth.
Melanoma
The association between Parkinson's disease and melanoma.
Melanoma
The current state of targeted therapy in melanoma: this time it's personal.
Melanoma
The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.
Melanoma
The double life of RIPK1.
Melanoma
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.
Melanoma
The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma.
Melanoma
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.
Melanoma
The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells.
Melanoma
The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma.
Melanoma
The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.
Melanoma
The oncogenic B-raf V599E mutation occurs more frequently in melanomas at sun-protected body sites.
Melanoma
The pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapy.
Melanoma
The role of mitogen- and stress-activated protein kinase pathways in melanoma.
Melanoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Melanoma
The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis.
Melanoma
The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway.
Melanoma
The use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients.
Melanoma
Therapeutic Implications of Targeting AKT Signaling in Melanoma.
Melanoma
Therapeutic strategies for targeting ras proteins.
Melanoma
Tissue microarray analysis of ezrin, KBA.62, CD166, nestin, and p-Akt in melanoma versus banal and atypical nevi, and nonmelanocytic lesions.
Melanoma
Tracking of Glycans Structure and Metallomics Profiles in BRAF Mutated Melanoma Cells Treated with Vemurafenib.
Melanoma
Trametinib for the treatment of melanoma.
Melanoma
Translating Nanomedicine to Comparative Oncology-the Case for Combining Zinc Oxide Nanomaterials with Nucleic Acid Therapeutic and Protein Delivery for Treating Metastatic Cancer.
Melanoma
Tumor adaptation and resistance to RAF inhibitors.
Melanoma
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Melanoma
Vemurafenib Induces Senescence Features in Melanoma Cells.
Melanoma
Vemurafenib: the road to personalized medicine in melanoma.
Melanoma
Who's Driving? Switch of Drivers in Immunotherapy-Treated Progressing Sinonasal Melanoma.
Melanoma
Withania somnifera extract attenuates stem cell factor-stimulated pigmentation in human epidermal equivalents through interruption of ERK phosphorylation within melanocytes.
Melanoma
WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial - mesenchymal transition.
Melanoma
[Clinicopathological significance of expression of IGF-1R in uveal melanoma and its association with expression of p-AKT Thr308].
Melanoma
[Melanoma: from molecular studies to the treatment breakthrough].
Melanoma
[Treatment of patients with brain metastases from a melanoma].
Melanoma, Amelanotic
Coriolus versicolor-derived protein-bound polysaccharides trigger the caspase-independent cell death pathway in amelanotic but not melanotic melanoma cells.
Melanoma, Experimental
Aglycone of Rh4 inhibits melanin synthesis in B16 melanoma cells: possible involvement of the protein kinase A pathway.
Melanoma, Experimental
GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes.
Melanoma, Experimental
Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
MELAS Syndrome
Detection of 14-3-3 protein in the cerebrospinal fluid in mitochondrial encephalopathy with lactic acidosis and stroke-like episodes.
Memory Disorders
A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.
Memory Disorders
Activation of calcium/calmodulin-dependent protein kinases after traumatic brain injury.
Memory Disorders
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.
Memory Disorders
Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments.
Memory Disorders
AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation.
Memory Disorders
Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.
Memory Disorders
Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin.
Memory Disorders
Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats.
Memory Disorders
Domoic acid induces a long-lasting enhancement of CA1 field responses and impairs tetanus-induced long-term potentiation in rat hippocampal slices.
Memory Disorders
Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.
Memory Disorders
Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease.
Memory Disorders
Effects of Ginsenoside Rb1 on Expressions of Phosphorylation Akt/Phosphorylation mTOR/Phosphorylation PTEN in Artificial Abnormal Hippocampal Microenvironment in Rats.
Memory Disorders
Endoplasmic reticulum stress induces spatial memory deficits by activating GSK-3.
Memory Disorders
Endothelial ErbB4 deficit induces alterations in exploratory behavior and brain energy metabolism in mice.
Memory Disorders
Escitalopram Ameliorates Tau Hyperphosphorylation and Spatial Memory Deficits Induced by Protein Kinase A Activation in Sprague Dawley Rats.
Memory Disorders
Glycogen synthase kinase-3 inhibition rescues sex-dependent contextual fear memory deficit in human immunodeficiency virus-1 transgenic mice.
Memory Disorders
GSK-3 is essential in the pathogenesis of Alzheimer's disease.
Memory Disorders
Inhibition of PKA attenuates memory deficits induced by ?-amyloid (1-42), and decreases oxidative stress and NF-?B transcription factors.
Memory Disorders
Lithium Attenuates Scopolamine-Induced Memory Deficits with Inhibition of GSK-3? and Preservation of Postsynaptic Components.
Memory Disorders
Loss of activated CaMKII at the synapse underlies Alzheimer's disease memory loss.
Memory Disorders
Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment.
Memory Disorders
Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.
Memory Disorders
O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease.
Memory Disorders
Pharmacological activation of protein kinase A improves memory loss and neuropathological changes in a mouse model of dementia of Alzheimer's type.
Memory Disorders
Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor.
Memory Disorders
Protection from amyloid ? peptide-induced memory, biochemical and morphological deficits by a phosphodiesterase-4D (PDE4D) allosteric inhibitor.
Memory Disorders
Protein kinase A as a therapeutic target for memory disorders: rationale and challenges.
Memory Disorders
Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure.
Memory Disorders
Rolipram rescues memory consolidation deficits caused by sleep deprivation: Implication of the cAMP/PKA and cAMP/Epac pathways.
Memory Disorders
Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice.
Memory Disorders
Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3.
Memory Disorders
The first Chinese case of Creutzfeldt-Jakob disease with mutation of E200K in PRNP.
Meniere Disease
Proto-oncogene Raf-1 as an autoantigen in Meniere's disease.
Meningioma
A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/?-catenin signaling pathway.
Meningioma
Aberrant CpG island hypermethylation profile is associated with atypical and anaplastic meningiomas.
Meningioma
Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development.
Meningioma
Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression.
Meningioma
Expression of astrocyte elevated gene-1 (AEG-1) in human meningiomas and its roles in cell proliferation and survival.
Meningioma
Fibroblast growth factor receptor-3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase-Akt pathway.
Meningioma
Next generation sequencing identifies novel potential actionable mutations for grade I meningioma treatment.
Meningioma
Pathological classification and molecular genetics of meningiomas.
Meningioma
Protein Kinase A Distribution in Meningioma.
Meningioma
STK11 mutation status is associated with decreased survival in meningiomas.
Meningioma
The expression of seven 14-3-3 isoforms in human meningioma.
Meningitis
Dexamethasone Downregulates Expressions of 14-3-3? and ?-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection.
Meningitis
Increased 14-3-3? and ? protein isoform expressions in parasitic eosinophilic meningitis caused by Angiostrongylus cantonensis infection in mice.
Meningitis
Pharmacological targets and mechanisms of calycosin against meningitis.
Meningitis
[Cerebrospinal fluid diagnosis of Creutzfeldt-Jakob disease]
Meningitis, Aseptic
The value of serial cerebrospinal fluid 14-3-3 protein levels in adult community-acquired bacterial meningitis.
Meningitis, Bacterial
Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis.
Meningitis, Bacterial
The value of serial cerebrospinal fluid 14-3-3 protein levels in adult community-acquired bacterial meningitis.
Meningoencephalitis
14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients.
Meningoencephalitis
Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis.
Meningoencephalitis
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
Menkes Kinky Hair Syndrome
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Menorrhagia
RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis.
Mental Retardation, X-Linked
CASK phosphorylation by PKA regulates the protein-protein interactions of CASK and expression of the NMDAR2b gene.
Mental Retardation, X-Linked
The nucleosome assembly protein TSPYL2 regulates the expression of NMDA receptor subunits GluN2A and GluN2B.
Mental Retardation, X-Linked
X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth.
Mesothelioma
Baicalin Regulates Proliferation, Apoptosis, Migration, and Invasion in Mesothelioma.
Mesothelioma
c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells.
Mesothelioma
CK2¿, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells.
Mesothelioma
Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer.
Mesothelioma
mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.
Mesothelioma
Novel LRRK2 mutations and other rare, non-BAP1-related candidate tumor predisposition gene variants in high-risk cancer families with mesothelioma and other tumors.
Mesothelioma
Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation.
Mesothelioma
Ras pathway activation in malignant mesothelioma.
Mesothelioma
The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma.
Mesothelioma, Malignant
A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma.
Mesothelioma, Malignant
[Epidermal growth factor receptor aberrations in malignant mesotheliomas]
Metabolic Diseases
Activation of mTOR/I?B-?/NF-?B pathway contributes to LPS-induced hypotension and inflammation in rats.
Metabolic Diseases
Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?
Metabolic Diseases
Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3?) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity.
Metabolic Diseases
GLUT4 exocytosis.
Metabolic Diseases
Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner.
Metabolic Diseases
Phenotypic relationships of common health disorders in dairy cows to lactation persistency estimated from daily milk weights.
Metabolic Diseases
Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor.
Metabolic Diseases
Role of CaMKII in the regulation of fatty acids and lipid metabolism.
Metabolic Diseases
Targeting mammalian serine/threonine-protein kinase 4 through Yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis.
Metabolic Diseases
Tissue-Specific Approaches Reveal Diverse Metabolic Functions of Rho-Kinase 1.
Metabolic Syndrome
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.
Metabolic Syndrome
Beneficial Effect of a Multistrain Synbiotic Prodefen® Plus on the Systemic and Vascular Alterations Associated with Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide Synthase and Protein Kinase A.
Metabolic Syndrome
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice.
Metabolic Syndrome
Cardioprotection by postconditioning is lost in WOKW rats with metabolic syndrome: role of glycogen synthase kinase 3beta.
Metabolic Syndrome
Enhanced peripheral blood miR-324-5p is associated with the risk of metabolic syndrome by suppressing ROCK1.
Metabolic Syndrome
Glibenclamide restores dopaminergic reward circuitry in obese mice through interscauplar brown adipose tissue.
Metabolic Syndrome
Insulin Signaling, GSK-3, Heat Shock Proteins and the Natural History of Type 2 Diabetes Mellitus: A Hypothesis.
Metabolic Syndrome
Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.
Metabolic Syndrome
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Metabolic Syndrome
Metabolic syndrome does not influence the phenotype of LRRK2 and GBA related Parkinson's disease.
Metabolic Syndrome
mTOR coordinates protein synthesis, mitochondrial activity and proliferation.
Metabolic Syndrome
Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.
Metabolic Syndrome
Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome.
Metabolic Syndrome
Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy.
Metabolic Syndrome
Structural basis for compound C inhibition of the human AMP-activated protein kinase ?2 subunit kinase domain.
Metabolic Syndrome
The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice.
Metabolic Syndrome
[Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease].
Metabolic Syndrome
[Potential impact of carbohydrate and fat intake on cardiac hypertrophy]
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure.
Metrorrhagia
Enzyme activity dot blots: a rapid and convenient assay for acetyltransferase or protein kinase activity immobilized on nitrocellulose.
Microcephaly
De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features.
Microcephaly
Evaluating the Role of MAST1 as an Intellectual Disability Disease Gene: Identification of a Novel De Novo Variant in a Patient with Developmental Disabilities.
Microcephaly
Human microcephaly.
Microcephaly
Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum.
Microcephaly
Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size.
Microcephaly
Missense mutations in CASK, coding for the calcium-/calmodulin-dependent serine protein kinase, interfere with neurexin binding and neurexin-induced oligomerization.
Microcephaly
Mutations in CIT, encoding citron rho-interacting serine/threonine kinase, cause severe primary microcephaly in humans.
Microcephaly
Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Microcephaly
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling.
Microphthalmos
Cyclic AMP a key messenger in the regulation of skin pigmentation.
Microphthalmos
Inhibition of melanogenic activity by 4,4'-dihydroxybiphenyl in melanoma cells.
Microphthalmos
Isolation and mapping of a polymorphic CA repeat sequence at the human VRK1 locus.
Microphthalmos
Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway.
Microphthalmos
Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway.
Migraine Disorders
CaMKII-dependent endoplasmic reticulum fission by whisker stimulation and during cortical spreading depolarization.
Migraine Disorders
Casein kinase i? mutations in familial migraine and advanced sleep phase.
Migraine Disorders
Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders.
Miosis
Combined effects of H7 and pilocarpine on anterior segment physiology in monkey eyes.
Mitochondrial Diseases
Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy.
Mitochondrial Myopathies
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
mitochondrial protein-transporting atpase deficiency
HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis.
Mixed Connective Tissue Disease
Antibodies to casein kinase II in sera of patients with mixed connective tissue disease: evaluation with recombinant proteins.
Molluscum Contagiosum
Sequence analysis of a Molluscum contagiosum virus DNA region which includes the gene encoding protein kinase 2 and other genes with unique organization.
Molluscum Contagiosum
Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase.
Mononeuropathies
Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice.
Mononeuropathies
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy.
Mononeuropathies
Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy.
Mononeuropathies
Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy.
Motor Neuron Disease
Cerebrospinal fluid biomarkers in clinically isolated syndromes and multiple sclerosis.
Motor Neuron Disease
In Vitro Modelling of Nerve-Muscle Connectivity in a Compartmentalised Tissue Culture Device.
Motor Neuron Disease
LRRK2 and neurodegeneration.
Motor Neuron Disease
Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy.
Motor Neuron Disease
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
Mouth Neoplasms
AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells.
Mouth Neoplasms
Akt2 and p-Akt overexpression in oral cancer cells is due to a reduced rate of protein degradation.
Mouth Neoplasms
Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression.
Mouth Neoplasms
Casein kinase 1 epsilon expression predicts poorer prognosis in low T-stage oral cancer patients.
Mouth Neoplasms
Combination of Taxol® and dichloroacetate results in synergistically inhibitory effects on Taxol-resistant oral cancer cells under hypoxia.
Mouth Neoplasms
Correlation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer.
Mouth Neoplasms
Costunolide Induces Apoptosis via the Reactive Oxygen Species and Protein Kinase B Pathway in Oral Cancer Cells.
Mouth Neoplasms
Cytoplasmic accumulation of activated leukocyte cell adhesion molecule is a predictor of disease progression and reduced survival in oral cancer patients.
Mouth Neoplasms
Effects of miR-34b/miR-892a Upregulation and Inhibition of ABCB1/ABCB4 on Melatonin-Induced Apoptosis in VCR-Resistant Oral Cancer Cells.
Mouth Neoplasms
Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer.
Mouth Neoplasms
Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression.
Mouth Neoplasms
Glycogen synthase kinase 3 beta: can it be a target for oral cancer.
Mouth Neoplasms
Identification of 14-3-3zeta associated protein networks in oral cancer.
Mouth Neoplasms
Identification of a six-gene prognostic signature for oral squamous cell carcinoma.
Mouth Neoplasms
Impact of Polymorphisms in Casein Kinase 1 Epsilon and Environmental Factors in Oral Cancer Susceptibility.
Mouth Neoplasms
Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma.
Mouth Neoplasms
Methylation and intratumoural heterogeneity of 14-3-3 sigma in oral cancer.
Mouth Neoplasms
Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3.
Mouth Neoplasms
Overexpression and activation of Akt2 protein in oral squamous cell carcinoma.
Mouth Neoplasms
RAF Kinase Inhibitory Protein Expression and Phosphorylation Profiles in Oral Cancers.
Mouth Neoplasms
Reversion-inducing cysteine-rich protein with Kazal motifs and its regulation by glycogen synthase kinase 3 signaling in oral cancer.
Movement Disorders
A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation.
Movement Disorders
A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson's Disease in Participants With Leucine-Rich Repeat Kinase 2 Mutation.
Movement Disorders
A Possible Modifying Effect of the G2019S Mutation in the LRRK2 Gene on GBA Parkinson's Disease.
Movement Disorders
Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease.
Movement Disorders
Anti-N-methyl-D-Aspartate Receptor Encephalitis Mimicking Sporadic Creutzfeldt-Jakob Disease.
Movement Disorders
Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression.
Movement Disorders
Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls.
Movement Disorders
Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers.
Movement Disorders
Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study.
Movement Disorders
Clustering of motor and nonmotor traits in leucine-rich repeat kinase 2 G2019S Parkinson's disease nonparkinsonian relatives: A multicenter family study.
Movement Disorders
Crystal structure of the WD40 domain dimer of LRRK2.
Movement Disorders
Evaluating the Role of SNCA, LRRK2, and GBA in Chinese Patients With Early-Onset Parkinson's Disease.
Movement Disorders
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.
Movement Disorders
Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.
Movement Disorders
Genetic testing for Parkinson disease: current practice, knowledge, and attitudes among US and Canadian movement disorders specialists.
Movement Disorders
Genetics of Parkinson's disease in the Polish population.
Movement Disorders
Genotype-Phenotype Relations for the Atypical Parkinsonism Genes: MDSGene Systematic Review.
Movement Disorders
Genotype-phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review.
Movement Disorders
Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease.
Movement Disorders
LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease.
Movement Disorders
LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies.
Movement Disorders
LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.
Movement Disorders
LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease.
Movement Disorders
LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
Movement Disorders
LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients.
Movement Disorders
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin.
Movement Disorders
Movement disorders rounds: A case of missing pathology in a patient with LRRK2 Parkinson's disease.
Movement Disorders
New synaptic and molecular targets for neuroprotection in Parkinson's disease.
Movement Disorders
Olfactory deficits and cardiac (123) I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations.
Movement Disorders
Olfactory Dysfunction in Parkinson's Disease Patients with the LRRK2 G2385R Variant.
Movement Disorders
Olfactory heterogeneity in LRRK2 related Parkinsonism.
Movement Disorders
Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics.
Movement Disorders
Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.
Movement Disorders
Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry.
Movement Disorders
PRKN, DJ-1, and PINK1 screening identifies novel splice site mutation in PRKN and two novel DJ-1 mutations.
Movement Disorders
Rab GTPases as Physiological Substrates of LRRK2 Kinase.
Movement Disorders
Recurrent LRRK2 (Park8) mutations in early-onset Parkinson's disease.
Movement Disorders
Rho kinase II interference by small hairpin RNA ameliorates 1?methyl?4?phenyl?1,2,3,6?tetrahydropyridine?induced parkinsonism in mice.
Movement Disorders
Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease.
Movement Disorders
Sleep aspects on video-polysomnography in LRRK2 mutation carriers.
Movement Disorders
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration.
Movement Disorders
Understanding the role of genetic variability in LRRK2 in Indian population.
MPTP Poisoning
Mechanism of Nanotization-Mediated Improvement in the Efficacy of Caffeine Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinsonism.
Mucocutaneous Lymph Node Syndrome
Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease.
Multiple Endocrine Neoplasia
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia.
Multiple Endocrine Neoplasia
Carney Complex.
Multiple Endocrine Neoplasia
In Vitro Studies of Novel PRKAR1A Mutants that Extend the Predicted RI? Protein Sequence into the 3'-Untranslated Open Reading Frame: Proteasomal Degradation Leads to RI? Haploinsufficiency and Carney Complex.
Multiple Endocrine Neoplasia
Molecular genetic advances in pituitary tumor development.
Multiple Endocrine Neoplasia
The genetics of pituitary adenomas.
Multiple Endocrine Neoplasia Type 1
Molecular genetic advances in pituitary tumor development.
Multiple Endocrine Neoplasia Type 1
The genetics of pituitary adenomas.
Multiple Endocrine Neoplasia Type 2a
Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.
Multiple Myeloma
A Multicenter Phase II Study of Single-agent Enzastaurin in Previously Treated Multiple Myeloma.
Multiple Myeloma
AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.
Multiple Myeloma
Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells.
Multiple Myeloma
Binding of B-cell maturation antigen to B-cell activating factor induces survival of multiple myeloma cells by activating Akt and JNK signaling pathways.
Multiple Myeloma
Bone marrow stromal cell-fueled multiple myeloma growth and osteoclastogenesis are sustained by protein kinase CK2.
Multiple Myeloma
CK2-An Emerging Target for Neurological and Psychiatric Disorders.
Multiple Myeloma
Combining the mammalian target of rapamycin inhibitor, rapamycin, with resveratrol has a synergistic effect in multiple myeloma.
Multiple Myeloma
Correlation of A-Kinase Interacting Protein 1 With Clinical Features, Treatment Response, and Survival Profiles in Patients With Multiple Myeloma.
Multiple Myeloma
Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
Multiple Myeloma
CSNK1?1 mediates malignant plasma cell survival.
Multiple Myeloma
Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells in vitro and in vivo by modulating multiple cellular pathways.
Multiple Myeloma
Delineating the mTOR kinase pathway using a dual TORC1/2 inhibitor, AZD8055, in multiple myeloma.
Multiple Myeloma
Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors.
Multiple Myeloma
Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors.
Multiple Myeloma
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.
Multiple Myeloma
Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo.
Multiple Myeloma
Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.
Multiple Myeloma
Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia.
Multiple Myeloma
EphA4 promotes cell proliferation and cell adhesion-mediated drug resistance via the AKT pathway in multiple myeloma.
Multiple Myeloma
Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies.
Multiple Myeloma
Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer.
Multiple Myeloma
Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma.
Multiple Myeloma
Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death.
Multiple Myeloma
Growth control of multiple myeloma cells through inhibition of glycogen synthase kinase-3.
Multiple Myeloma
How wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow.
Multiple Myeloma
Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.
Multiple Myeloma
Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3.
Multiple Myeloma
Inhibition of Pim-2 kinase by LT-171-861 promotes DNA damage and exhibits enhanced lethal effects with PARP inhibitor in multiple myeloma.
Multiple Myeloma
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation.
Multiple Myeloma
MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4.
Multiple Myeloma
Multiple myeloma cell survival relies on high activity of protein kinase CK2.
Multiple Myeloma
Nek2 is a novel regulator of B cell development and immunological response.
Multiple Myeloma
New insights into RSK activation and hematopoietic cancer.
Multiple Myeloma
p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.
Multiple Myeloma
Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Multiple Myeloma
PI3K? and PI3K? isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment.
Multiple Myeloma
Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.
Multiple Myeloma
Potent antitumor effect of combination therapy with sub-optimal doses of Akt inhibitors and pomalidomide plus dexamethasone in multiple myeloma.
Multiple Myeloma
Protein Kinase CK2 Inhibition Down Modulates the NF-?B and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells.
Multiple Myeloma
Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth.
Multiple Myeloma
Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.
Multiple Myeloma
Protein Kinase D 1 Predicts Poor Treatment Response and Unfavorable Survival of Bortezomib-Based Treatment, and Its Knockdown Enhances Drug Sensitivity to Bortezomib in Multiple Myeloma.
Multiple Myeloma
Reactive Oxygen Species-Mediated Activation of AMP-Activated Protein Kinase and c-Jun N-terminal Kinase Plays a Critical Role in Beta-Sitosterol-Induced Apoptosis in Multiple Myeloma U266 cells.
Multiple Myeloma
Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs.
Multiple Myeloma
Structural basis of lenalidomide-induced CK1? degradation by the CRL4(CRBN) ubiquitin ligase.
Multiple Myeloma
The Effect of Ras Homolog C/Rho-Associated Coiled-Protein Kinase (Rho/ROCK) Signaling Pathways on Proliferation and Apoptosis of Human Myeloma Cells.
Multiple Myeloma
The mTOR Signaling Pathway is an Emerging Therapeutic Target in Multiple Myeloma.
Multiple Myeloma
The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma.
Multiple Myeloma
Unique Pattern of Overexpression of Raf-1 Kinase Inhibitory Protein in Its Inactivated Phosphorylated Form in Human Multiple Myeloma.
Multiple Myeloma
Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1.
Multiple Myeloma
[Inhibitory effect of phenylhexyl isothiocyanate on notch signaling of multiple myeloma cells in vitro].
Multiple Myeloma
[Targeting Notch1 Gene Inhibits the Proliferation of Multiple Myeloma Cells].
Multiple Sclerosis
14-3-3 Protein in the cerebrospinal fluid of patients with acute transverse myelitis and multiple sclerosis.
Multiple Sclerosis
14-3-3 protein in the CSF as prognostic marker in early multiple sclerosis.
Multiple Sclerosis
A single-nucleotide polymorphism in serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor for multiple sclerosis.
Multiple Sclerosis
Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.
Multiple Sclerosis
Anti-Inflammatory Effect of KW-2449 on Autoimmune Encephalomyelitis: An Experimental Study on Mice.
Multiple Sclerosis
Biochemical markers of damage of the central nervous system in multiple sclerosis.
Multiple Sclerosis
c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis.
Multiple Sclerosis
Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers.
Multiple Sclerosis
Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis.
Multiple Sclerosis
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Multiple Sclerosis
GD1a overcomes inhibition of myelination by fibronectin via activation of protein kinase A. Implications for multiple sclerosis.
Multiple Sclerosis
Increased 14-3-3 immunoreactivity in glial elements in patients with multiple sclerosis.
Multiple Sclerosis
Inflammatory Diseases Among Norwegian LRRK2 Mutation Carriers. A 15-Years Follow-Up of a Cohort.
Multiple Sclerosis
Role of glial 14-3-3 gamma protein in autoimmune demyelination.
Multiple Sclerosis
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.
Multiple Sclerosis
Tau protein and 14-3-3 are elevated in the cerebrospinal fluid of patients with multiple sclerosis and correlate with intrathecal synthesis of IgG.
Multiple Sclerosis
Tau protein: a possible prognostic factor in optic neuritis and multiple sclerosis.
Multiple Sclerosis
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
Multiple Sclerosis
The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes.
Multiple Sclerosis
The 14-3-3 protein in multiple sclerosis: a marker of disease severity.
Multiple Sclerosis
The role of glycogen synthase kinase 3 beta in multiple sclerosis.
Multiple Sclerosis, Relapsing-Remitting
Glioblastoma following treatment with fingolimod for relapsing-remitting multiple sclerosis.
Multiple System Atrophy
A patient clinically diagnosed as multiple system atrophy harboring LRRK2 p.G2019S.
Multiple System Atrophy
Accumulation of 14-3-3 proteins in glial cytoplasmic inclusions in multiple system atrophy.
Multiple System Atrophy
An association analysis of the R1628P and G2385R polymorphisms of the LRRK2 gene in multiple system atrophy in a Chinese population.
Multiple System Atrophy
Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease.
Multiple System Atrophy
Analysis of the LRRK2 Gly2385Arg variant in primary dystonia and multiple system atrophy in Taiwan.
Multiple System Atrophy
Early-onset pathologically proven multiple system atrophy with LRRK2 G2019S mutation.
Multiple System Atrophy
G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy.
Multiple System Atrophy
Glycogen synthase kinase-3beta is associated with Parkinson's disease.
Multiple System Atrophy
Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy.
Multiple System Atrophy
Inflammation kinase PKR phosphorylates ?-synuclein and causes ?-synuclein-dependent cell death.
Multiple System Atrophy
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.
Multiple System Atrophy
LRRK2 exonic variants and risk of multiple system atrophy.
Multiple System Atrophy
LRRK2 p.Ile1371Val Mutation in a Case with Neuropathologically Confirmed Multi-System Atrophy.
Multiple System Atrophy
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Multiple System Atrophy
Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy.
Multiple System Atrophy
The G2019S LRRK2 Mutation is Rare in Korean Patients with Parkinson's Disease and Multiple System Atrophy.
Multiple System Atrophy
[Clinical molecular genetics for PARK8 (LRRK2)]
Multiple System Atrophy
[Parkinson's disease associated to mutation of the LRRK2 gene, mimicking multisystemic atrophy due to the combination of parkinsonism, early-onset dysautonomia and normal cardiac scintigraphy].
Muscle Hypotonia
De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features.
Muscle Hypotonia
What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.
Muscle Spasticity
Role of endothelial NO synthase phosphorylation in cerebrovascular protective effect of recombinant erythropoietin during subarachnoid hemorrhage-induced cerebral vasospasm.
Muscle Weakness
Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.
Muscle Weakness
Enhanced serum immunoglobulin G clearance in myotonic dystrophy-associated hypogammaglobulinemia: a case series and review of the literature.
Muscular Atrophy
Absence of morphological and molecular correlates of sarcopenia in the macaque tongue muscle styloglossus.
Muscular Atrophy
Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy.
Muscular Atrophy
Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression.
Muscular Atrophy
Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.
Muscular Atrophy
Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase ?, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge.
Muscular Atrophy
Association of spinal and bulbar muscular atrophy with myotonic dystrophy type 1.
Muscular Atrophy
Down-regulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia.
Muscular Atrophy
Effect of branched-chain amino acid supplementation during unloading on regulatory components of protein synthesis in atrophied soleus muscles.
Muscular Atrophy
Effects of insulin-like growth factor 1 on muscle atrophy and motor function in rats with brain ischemia.
Muscular Atrophy
Electrostimulation during hindlimb unloading modulates PI3K-AKT downstream targets without preventing soleus atrophy and restores slow phenotype through ERK.
Muscular Atrophy
Glycogen synthase kinase 3 suppresses myogenic differentiation through negative regulation of NFATc3.
Muscular Atrophy
GSK-3beta activity is increased in skeletal muscle after burn injury in rats.
Muscular Atrophy
GSK3? inhibitor promotes myelination and mitigates muscle atrophy after peripheral nerve injury.
Muscular Atrophy
Heat stress alters muscle protein and amino acid metabolism and accelerates liver gluconeogenesis for energy supply in broilers.
Muscular Atrophy
Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs.
Muscular Atrophy
iTRAQ-coupled 2D LC-MS/MS analysis on differentially expressed proteins in denervated tibialis anterior muscle of Rattus norvegicus.
Muscular Atrophy
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) in skeletal muscle atrophy and hypertrophy.
Muscular Atrophy
Mountain ginseng inhibits skeletal muscle atrophy by decreasing muscle RING ?nger protein-1 and atrogin1 through forkhead box O3 in L6 myotubes.
Muscular Atrophy
Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Muscular Atrophy
Myostatin and Related Factors Are Involved in Skeletal Muscle Protein Breakdown in Growing Broilers Exposed to Constant Heat Stress.
Muscular Atrophy
Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy.
Muscular Atrophy
PI3 Kinase Regulation of Skeletal Muscle Hypertrophy and Atrophy.
Muscular Atrophy
Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats.
Muscular Atrophy
Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity.
Muscular Atrophy
The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans.
Muscular Atrophy
The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis.
Muscular Atrophy
TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling.
Muscular Atrophy
[Effects of electroacupuncture on proangiogenesis process and protein turnover in a mouse model of sarcopenia].
Muscular Atrophy
{beta}2-Integrins contribute to skeletal muscle hypertrophy in mice.
Muscular Atrophy, Spinal
Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy.
Muscular Atrophy, Spinal
Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of ?7 SMA KO Mouse Model of Spinal Muscular Atrophy.
Muscular Diseases
Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice.
Muscular Diseases
Apoptosis of skeletal muscle on steroid-induced myopathy in rats.
Muscular Diseases
Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.
Muscular Diseases
Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells.
Muscular Diseases
Increased amyloid ?-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy.
Muscular Diseases
Mechanical-stretch of C2C12 myoblasts inhibits expression of Toll-like receptor 3 (TLR3) and of autoantigens associated with inflammatory myopathies.
Muscular Diseases
Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy.
Muscular Diseases
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.
Muscular Diseases
Overexpression of Staufen1 in DM1 mouse skeletal muscle exacerbates dystrophic and atrophic features.
Muscular Diseases
Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility.
Muscular Diseases
Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of MMP-9 in myopathy.
Muscular Dystrophies
Abnormal Na channel gating in murine cardiac myocytes deficient in myotonic dystrophy protein kinase.
Muscular Dystrophies
Altered activity of signaling pathways in diaphragm and tibialis anterior muscle of dystrophic mice.
Muscular Dystrophies
An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type I.
Muscular Dystrophies
Deregulated protein kinase a signaling and myospryn expression in muscular dystrophy.
Muscular Dystrophies
Effects of age and gene dose on skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase.
Muscular Dystrophies
Molecular and clinical characteristics of myotonic dystrophy type 1 in koreans.
Muscular Dystrophies
Molecular genetics of myotonic dystrophy.
Muscular Dystrophies
Phospholemman is a substrate for myotonic dystrophy protein kinase.
Muscular Dystrophies
PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle.
Muscular Dystrophies
Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy.
Muscular Dystrophies
Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of ullrich disease fibroblasts.
Muscular Dystrophies
[Specific inhibition of nonsense-mediated mRNA decay has the potential to rescue the phenotype of muscular dystrophy]
Muscular Dystrophy, Duchenne
Altered protein kinase C and protein kinase A activities in erythrocyte membrane, platelets and lymphocytes of Duchenne muscular dystrophy (DMD) patients.
Muscular Dystrophy, Duchenne
Emerging strategies for cell and gene therapy of the muscular dystrophies.
Muscular Dystrophy, Duchenne
Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies.
Muscular Dystrophy, Duchenne
Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.
Muscular Dystrophy, Emery-Dreifuss
The Cutting Edge: The Role of mTOR Signaling in Laminopathies.
Muscular Dystrophy, Emery-Dreifuss
The Emery-Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A.
Muscular Dystrophy, Facioscapulohumeral
Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy.
Mutism
The associations of two SNPs in miRNA-146a and one SNP in ZBTB38-RASA2 with the disease susceptibility and the clinical features of the Chinese patients of sCJD and FFI.
Mycoses
Enhancing blast disease resistance by overexpression of the calcium-dependent protein kinase OsCPK4 in rice.
Myelitis
Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis.
Myelitis
Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma.
Myelitis, Transverse
14-3-3 Protein in the cerebrospinal fluid of patients with acute transverse myelitis and multiple sclerosis.
Myelitis, Transverse
14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis.
Myelitis, Transverse
Elevated 14-3-3 protein and axonal loss in immunoglobulin-responsive, idiopathic acute transverse myelitis.
Myelitis, Transverse
Inflammatory transverse myelitis: evolving concepts.
Myelodysplastic Syndromes
Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes.
Myelodysplastic Syndromes
Aberrant Methylation of Death-Associated Protein Kinase 1 CpG Islands in Myelodysplastic Syndromes.
Myelodysplastic Syndromes
An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes.
Myelodysplastic Syndromes
Analysis of Aurora kinase A expression in CD34(+) blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia.
Myelodysplastic Syndromes
BAY-43-9006 Bayer/Onyx.
Myelodysplastic Syndromes
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia.
Myelodysplastic Syndromes
Glycogen Synthase Kinase-3 and phospholipase C-beta signalling: Roles and possible interactions in myelodysplastic syndromes and acute myeloid leukemia.
Myelodysplastic Syndromes
Low level of DAP-kinase DNA methylation in myelodysplastic syndrome.
Myelodysplastic Syndromes
Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription.
Myelodysplastic Syndromes
Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.
Myelodysplastic Syndromes
Structural basis of lenalidomide-induced CK1? degradation by the CRL4(CRBN) ubiquitin ligase.
Myelodysplastic Syndromes
The role of autophagy in targeted therapy for acute myeloid leukemia.
Myelodysplastic Syndromes
Tumor-derived CK1? mutations enhance MDMX inhibition of p53.
Myeloproliferative Disorders
American Chemical Society - 240th national meeting - chemistry for preventing and combating disease: part 2.
Myocardial Infarction
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.
Myocardial Infarction
Activation of Peroxisome Proliferator-Activated Receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat.
Myocardial Infarction
Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1 signaling.
Myocardial Infarction
Ataxia telangiectasia mutated kinase deficiency impairs the autophagic response early during myocardial infarction.
Myocardial Infarction
Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.
Myocardial Infarction
Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits.
Myocardial Infarction
C-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction.
Myocardial Infarction
Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart.
Myocardial Infarction
Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by Inhibitor 1 of Protein Phosphatase 1 Protects Against Myocardial Ischemia-Reperfusion Injury.
Myocardial Infarction
Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo.
Myocardial Infarction
Calmodulin kinase II inhibition protects against structural heart disease.
Myocardial Infarction
CaMKII Activity in the Inflammatory Response of Cardiac Diseases.
Myocardial Infarction
CaMKII and stress mix it up in mitochondria.
Myocardial Infarction
CaMKII determines mitochondrial stress responses in heart.
Myocardial Infarction
CaMKII exacerbates heart failure progression by activating class I HDACs.
Myocardial Infarction
CaMKII-?9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair.
Myocardial Infarction
Cardioprotective effect of erythropoietin in rats with acute myocardial infarction through JNK pathway.
Myocardial Infarction
Clinical heterogeneity of the LRRK2 G2019S mutation.
Myocardial Infarction
Compatibility of Astragalus and Salvia extract inhibits myocardial fibrosis and ventricular remodeling by regulation of protein kinase D1 protein.
Myocardial Infarction
Deficiency of ataxia telangiectasia mutated kinase delays inflammatory response in the heart following myocardial infarction.
Myocardial Infarction
Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis.
Myocardial Infarction
Deficiency of ataxia-telangiectasia mutated kinase modulates functional and biochemical parameters of the heart in response to Western-type diet.
Myocardial Infarction
Dexmedetomidine alleviates cardiomyocyte apoptosis and cardiac dysfunction may be associated with inhibition of RhoA/ROCK pathway in mice with myocardial infarction.
Myocardial Infarction
Diabetes abolishes morphine-induced cardioprotection via multiple pathways upstream of glycogen synthase kinase-3beta.
Myocardial Infarction
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.
Myocardial Infarction
Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction.
Myocardial Infarction
Effect of disruption of Akt-1 of lin-c-kit+ stem cells on myocardial performance in infarcted heart.
Myocardial Infarction
Endoplasmic reticulum stress confers 5-fluorouracil resistance in breast cancer cell via the GRP78/OCT4/lncRNA MIAT/AKT pathway.
Myocardial Infarction
Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial Infarction by Activating ?-Arrestin-2, Protein Phosphatase 2A, and Glycogen Synthase Kinase-3 and Inhibiting ?-Catenin.
Myocardial Infarction
Glycogen Synthase Kinase-3{beta} Regulates Post-Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo.
Myocardial Infarction
Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction.
Myocardial Infarction
HSP20-mediated cardiomyocyte exosomes improve cardiac function in mice with myocardial infarction by activating Akt signaling pathway.
Myocardial Infarction
Huoxue Wentong Formula ameliorates myocardial infarction in rats through inhibiting CaMKII oxidation and phosphorylation.
Myocardial Infarction
Hydrogen sulfide protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by preventing GSK-3beta-dependent opening of mPTP.
Myocardial Infarction
Inhibition of glycogen synthase kinase-3? prevents sympathetic hyperinnervation in infarcted rats.
Myocardial Infarction
Interaction of ?1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling.
Myocardial Infarction
Involvement of HSP90 in ischemic postconditioning-induced cardioprotection by inhibition of the complement system, JNK and inflammation.
Myocardial Infarction
Methyl palmitate protects heart against ischemia/reperfusion-induced injury through G-protein coupled receptor 40-mediated activation of the PI3K/AKT pathway.
Myocardial Infarction
MicroRNA-147 inhibits myocardial inflammation and apoptosis following myocardial infarction via targeting HIPK2.
Myocardial Infarction
MicroRNA-325-3p protects the heart after myocardial infarction by inhibiting RIPK3 and programmed necrosis in mice.
Myocardial Infarction
miR-26a attenuates cardiac apoptosis and fibrosis by targeting ataxia-telangiectasia mutated in myocardial infarction.
Myocardial Infarction
MiR-26a inhibits myocardial cell apoptosis in rats with acute myocardial infarction through GSK-3? pathway.
Myocardial Infarction
MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction.
Myocardial Infarction
Over-expression of Kv4.3 gene reverses cardiac remodeling and transient-outward K+ current (Ito) reduction via CaMKII inhibition in myocardial infarction.
Myocardial Infarction
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Myocardial Infarction
Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.
Myocardial Infarction
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.
Myocardial Infarction
Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-?-independent manner.
Myocardial Infarction
Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.
Myocardial Infarction
Protein Kinases as Drug Development Targets for Heart Disease Therapy.
Myocardial Infarction
Regulatory role of CARD3 in left ventricular remodelling and dysfunction after myocardial infarction.
Myocardial Infarction
Repeated Non-Invasive Limb Ischemic Preconditioning Confers Cardioprotection Through PKC-?/STAT3 Signaling in Diabetic Rats.
Myocardial Infarction
Research on protective mechanism of ibuprofen in myocardial ischemia-reperfusion injury in rats through the PI3K/Akt/mTOR signaling pathway.
Myocardial Infarction
Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: insights from mathematical modeling.
Myocardial Infarction
Role of adiponectin in diabetes myocardial ischemia-reperfusion injury and ischemic postconditioning.
Myocardial Infarction
Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway.
Myocardial Infarction
Suppression of Ventricular Arrhythmias After Myocardial Infarction by AT1 Receptor Blockade: Role of the AT2 Receptor and Casein Kinase 2/Kir2.1 Pathway. Editorial to: "Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction Via Casein Kinase 2" by Xinran Li et al.
Myocardial Infarction
Targeting Glycogen Synthase Kinase 3 Beta Regulates CD47 Expression After Myocardial Infarction in Rats via the NF-?B Signaling Pathway.
Myocardial Infarction
The allosteric glycogen synthase kinase-3 inhibitor NP12 limits myocardial remodeling and promotes angiogenesis in an acute myocardial infarction model.
Myocardial Infarction
The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction.
Myocardial Infarction
The PI3K/Akt pathway mediates the protection of SO2 preconditioning against myocardial ischemia/reperfusion injury in rats.
Myocardial Infarction
The potential effects of anti-diabetic medications on myocardial ischemia-reperfusion injury.
Myocardial Infarction
The Protective Effect of Total Flavones from
Myocardial Infarction
The Role of Casein Kinase 2 in Ion Channel Remodeling After Myocardial Infarction. Editorial to: "Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction via Casein Kinase 2" by Xinran Li et al.
Myocardial Infarction
Tissue kallikrein infusion prevents cardiomyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction.
Myocardial Infarction
Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction via Casein Kinase 2.
Myocardial Infarction
Xenon preconditioning: the role of prosurvival signaling, mitochondrial permeability transition and bioenergetics in rats.
Myocardial Infarction
ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation.
Myocardial Infarction
[Ischemic preconditioning attenuates myocardial no-reflow and reperfusion injury after revascularization of acute myocardial infarction by reducing myocardial edema via the protein kinase A pathway].
Myocardial Infarction
[Structural and functional modifications of phospholamban and regulation of calcium transport in the sarcoplasmic reticulum under conditions of metabolic cardiac insufficiency.]
Myocardial Ischemia
A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580.
Myocardial Ischemia
A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.
Myocardial Ischemia
Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia.
Myocardial Ischemia
Deficiency of ataxia-telangiectasia mutated kinase modulates functional and biochemical parameters of the heart in response to Western-type diet.
Myocardial Ischemia
Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.
Myocardial Ischemia
Dynamic Alterations in the CaV1.2/CaM/CaMKII Signaling Pathway in the Left Ventricular Myocardium of Ischemic Rat Hearts.
Myocardial Ischemia
Dynamics of Ca(2+)/calmodulin-dependent protein kinase II following acute myocardial ischemia-translocation and autophosphorylation.
Myocardial Ischemia
HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1.
Myocardial Ischemia
Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice.
Myocardial Ischemia
Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats.
Myocardial Ischemia
MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia.
Myocardial Ischemia
Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity.
Myocardial Ischemia
p38 mitogen activated protein kinase mediates both death signaling and functional depression in the heart.
Myocardial Ischemia
Repetitive Transient Ischemia-Induced Cardiac Angiogenesis is Mediated by Camkii Activation.
Myocardial Ischemia
Role of GSK-3 in Cardiac Health: Focusing on Cardiac Remodeling and Heart Failure.
Myocardial Ischemia
[Effects of Electroacupuncture at Neiguan (PC6) on Protein Expressions of Raf-1, ERK 1/2, and p-ERK 1/2 of Rats with Myocardial Hypertrophy].
Myocardial Ischemia
[Endogenous nocciceptin/orphanin FQ affect ischemic arrhythmias in rats through Raf kinase inhibitor protein].
Myocardial Reperfusion Injury
CaMKII in Regulation of Cell Death During Myocardial Reperfusion Injury.
Myocardial Reperfusion Injury
Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3beta and mitochondrial permeability transition pore.
Myocardial Reperfusion Injury
N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3 beta.
Myocardial Reperfusion Injury
Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2.
Myocardial Stunning
Ca(2+) /calmodulin dependent kinase II: a critical mediator in determining reperfusion outcomes in the heart?
Myocarditis
Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis.
Myocarditis
Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies.
Myocarditis
Haploinsufficient Rock1+/- and Rock2+/- Mice Are Not Protected from Cardiac Inflammation and Postinflammatory Fibrosis in Experimental Autoimmune Myocarditis.
Myocarditis
Increased phosphorylation of Ca(2+) handling proteins as a proarrhythmic mechanism in myocarditis.
Myocarditis
Mimicry and antibody-mediated cell signaling in autoimmune myocarditis.
Myoclonic Epilepsies, Progressive
Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy.
Myoclonus
Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type 2.
Myoclonus
Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses: a clinicopathological study.
Myoclonus
Predictive Factors for Early Initiation of Artificial Feeding in Patients With Sporadic Creutzfeldt-Jakob Disease.
Myoclonus
The associations of two SNPs in miRNA-146a and one SNP in ZBTB38-RASA2 with the disease susceptibility and the clinical features of the Chinese patients of sCJD and FFI.
Myoclonus
Wernicke encephalopathy and Creutzfeldt-Jakob disease.
Myoepithelioma
Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein.
Myositis
Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis.
Myositis
In AbetaPP-overexpressing cultured human muscle fibers proteasome inhibition enhances phosphorylation of AbetaPP751 and GSK3beta activation: effects mitigated by lithium and apparently relevant to sporadic inclusion-body myositis.
Myositis
Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta.
Myositis, Inclusion Body
Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis.
Myositis, Inclusion Body
Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta.
Myotonia
Enhanced serum immunoglobulin G clearance in myotonic dystrophy-associated hypogammaglobulinemia: a case series and review of the literature.
Myotonia
Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy.
Myotonia
Myotonia congenita and myotonic dystrophy in the same family: coexistence of a CLCN1 mutation and expansion in the CNBP (ZNF9) gene.
Myotonic Dystrophy
(CTG)n expansion at DMPK locus seen only in muscle tissue: a novel case.
Myotonic Dystrophy
A 3.7kb fragment from the myotonic dystrophy protein kinase promoter directs neural-specific expression in vivo.
Myotonic Dystrophy
A case of myotonic dystrophy (MD) associated with glucose-induced hyperinsulinemia followed by reactive hypoglycemia and increased number of cytosine-thymine-guanine (CTG) trinucleotide repeats in MD gene.
Myotonic Dystrophy
A DM1 family with interruptions associated with atypical symptoms and late onset but not with a milder phenotype.
Myotonic Dystrophy
A new non-radioactive method for the screening and prenatal diagnosis of myotonic dystrophy patients.
Myotonic Dystrophy
A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes.
Myotonic Dystrophy
A rapid polymerase chain reaction-based test for screening Steinert's disease (DM1).
Myotonic Dystrophy
A role for myotonic dystrophy protein kinase in synaptic plasticity.
Myotonic Dystrophy
A study of DNA methylation in myotonic dystrophy.
Myotonic Dystrophy
A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis.
Myotonic Dystrophy
Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice.
Myotonic Dystrophy
Abnormal Na channel gating in murine cardiac myocytes deficient in myotonic dystrophy protein kinase.
Myotonic Dystrophy
Absence of myotonic dystrophy protein kinase (DMPK) mRNA as a result of a triplet repeat expansion in myotonic dystrophy.
Myotonic Dystrophy
Additive influence of maternal and offspring DM-kinase gene CTG repeat lengths in the genesis of congenital myotonic dystrophy.
Myotonic Dystrophy
Altered ?-adrenergic response in mice lacking myotonic dystrophy protein kinase.
Myotonic Dystrophy
Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localization.
Myotonic Dystrophy
An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type I.
Myotonic Dystrophy
Analysis of repetitive regions in myotonic dystrophy type 1 and 2.
Myotonic Dystrophy
Analysis of trinucleotide repeats in myotonic dystrophy.
Myotonic Dystrophy
Anticipation in myotonic dystrophy. II. Complex relationships between clinical findings and structure of the GCT repeat.
Myotonic Dystrophy
Application of FTA sample collection and DNA purification system on the determination of CTG trinucleotide repeat size by PCR-based Southern blotting.
Myotonic Dystrophy
Artificial mirtron-mediated gene knockdown: functional DMPK silencing in mammalian cells.
Myotonic Dystrophy
Association of spinal and bulbar muscular atrophy with myotonic dystrophy type 1.
Myotonic Dystrophy
Brain-specific change in alternative splicing of Tau exon 6 in myotonic dystrophy type 1.
Myotonic Dystrophy
Changes in myotonic dystrophy protein kinase levels and muscle development in congenital myotonic dystrophy.
Myotonic Dystrophy
Characteristics of intergenerational contractions of the CTG repeat in myotonic dystrophy.
Myotonic Dystrophy
Characterization and polymerase chain reaction (PCR) detection of an Alu deletion polymorphism in total linkage disequilibrium with myotonic dystrophy.
Myotonic Dystrophy
Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart.
Myotonic Dystrophy
Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene.
Myotonic Dystrophy
Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy.
Myotonic Dystrophy
Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron.
Myotonic Dystrophy
Clinical characteristics of pregnancies complicated by congenital myotonic dystrophy.
Myotonic Dystrophy
Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases.
Myotonic Dystrophy
Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization.
Myotonic Dystrophy
Coiled-coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms.
Myotonic Dystrophy
Combination of myotonic dystrophy and hereditary motor and sensory neuropathy.
Myotonic Dystrophy
Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties.
Myotonic Dystrophy
CTG repeat lengths of the DMPK gene in myotonic dystrophy patients compared to healthy controls in Thailand.
Myotonic Dystrophy
CTG repeat polymorphism in DMPK gene in healthy Yugoslav population.
Myotonic Dystrophy
CTG repeats at the myotonic protein kinase gene in a healthy Chilean population sample.
Myotonic Dystrophy
Cytoplasmic and nuclear retained DMPK mRNAs are targets for RNA interference in myotonic dystrophy cells.
Myotonic Dystrophy
De novo myotonic dystrophy mutation in a Nigerian kindred.
Myotonic Dystrophy
Decreased DMPK transcript levels in myotonic dystrophy 1 type IIA muscle fibers.
Myotonic Dystrophy
Decreased expression of DMPK: correlation with CTG repeat expansion and fibre type composition in myotonic dystrophy type 1.
Myotonic Dystrophy
Decreased expression of myotonic dystrophy protein kinase and disorganization of sarcoplasmic reticulum in skeletal muscle of myotonic dystrophy.
Myotonic Dystrophy
Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy.
Myotonic Dystrophy
Decreased levels of myotonic dystrophy protein kinase (DMPK) and delayed differentiation in human myotonic dystrophy myoblasts.
Myotonic Dystrophy
Decreased myotonin-protein kinase in the skeletal and cardiac muscles in myotonic dystrophy.
Myotonic Dystrophy
Definition of regulatory sequence elements in the promoter region and the first intron of the myotonic dystrophy protein kinase gene.
Myotonic Dystrophy
Detection of the CTG repeat expansion in congenital myotonic dystrophy.
Myotonic Dystrophy
Development of a genomic DNA reference material panel for myotonic dystrophy type 1 (DM1) genetic testing.
Myotonic Dystrophy
Developmental changes in expression of myotonic dystrophy protein kinase in the rat central nervous system.
Myotonic Dystrophy
Developmental expression of myotonic dystrophy protein kinase in brain and its relevance to clinical phenotype.
Myotonic Dystrophy
Developmental expression of serum response factor in the rat central nervous system.
Myotonic Dystrophy
Developmental regulation of myotonic dystrophy protein kinase in human muscle cells in vitro.
Myotonic Dystrophy
Differences in splicing defects between the grey and white matter in myotonic dystrophy type 1 patients.
Myotonic Dystrophy
Direct detection of expanded (CAG/CTG) repeats in the myotonin-protein kinase genes of myotonic dystrophy patients using a high-stringency hybridization method.
Myotonic Dystrophy
Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors.
Myotonic Dystrophy
DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model.
Myotonic Dystrophy
DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death.
Myotonic Dystrophy
DMPK mRNA Expression in Human Brain Tissue Throughout the Lifespan.
Myotonic Dystrophy
DMPK protein isoforms are differentially expressed in myogenic and neural cell lineages.
Myotonic Dystrophy
Drosophila warts--tumor suppressor and member of the myotonic dystrophy protein kinase family.
Myotonic Dystrophy
Effect of the myotonic dystrophy (DM) mutation on mRNA levels of the DM gene.
Myotonic Dystrophy
Effects of age and gene dose on skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase.
Myotonic Dystrophy
Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells.
Myotonic Dystrophy
Elongation of (CTG)n repeats in myotonic dystrophy protein kinase gene in tumors associated with myotonic dystrophy patients.
Myotonic Dystrophy
Emerging strategies for cell and gene therapy of the muscular dystrophies.
Myotonic Dystrophy
Endocrine Dysfunction in Patients with Myotonic Dystrophy.
Myotonic Dystrophy
Enhanced serum immunoglobulin G clearance in myotonic dystrophy-associated hypogammaglobulinemia: a case series and review of the literature.
Myotonic Dystrophy
Environmental suppression of Neurospora crassa cot-1 hyperbranching: a link between COT1 kinase and stress sensing.
Myotonic Dystrophy
ETR-1, a homologue of a protein linked to myotonic dystrophy, is essential for muscle development in Caenorhabditis elegans.
Myotonic Dystrophy
Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.
Myotonic Dystrophy
Evidence for localization of the myotonic dystrophy protein kinase to the terminal cisternae of the sarcoplasmic reticulum.
Myotonic Dystrophy
Expanding complexity in myotonic dystrophy.
Myotonic Dystrophy
Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.
Myotonic Dystrophy
Expansion of the myotonic dystrophy gene in Italian and Spanish patients.
Myotonic Dystrophy
Expression and localization of myotonic dystrophy protein kinase in human skeletal muscle cells determined with a novel antibody: possible role of the protein in cytoskeleton rearrangements during differentiation.
Myotonic Dystrophy
Expression of myotonic dystrophy protein kinase gene during in vivo and in vitro mouse myogenesis.
Myotonic Dystrophy
Expression of myotonic dystrophy protein kinase in biopsied muscles.
Myotonic Dystrophy
Failure in detecting mRNA transcripts from the mutated allele in myotonic dystrophy muscle.
Myotonic Dystrophy
Familial left ventricular hypertrabeculation in myotonic dystrophy type 1.
Myotonic Dystrophy
Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle.
Myotonic Dystrophy
Fluorescence in situ hybridization analysis of the replication properties of the myotonic dystrophy protein kinase (DMPK) gene region.
Myotonic Dystrophy
Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.
Myotonic Dystrophy
Genomic organization and transcriptional units at the myotonic dystrophy locus.
Myotonic Dystrophy
Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity.
Myotonic Dystrophy
Hammerhead ribozyme-mediated destruction of nuclear foci in myotonic dystrophy myoblasts.
Myotonic Dystrophy
High-fat diet induced adiposity and insulin resistance in mice lacking the myotonic dystrophy protein kinase.
Myotonic Dystrophy
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.
Myotonic Dystrophy
Homodimerization through coiled-coil regions enhances activity of the myotonic dystrophy protein kinase.
Myotonic Dystrophy
Homozygous myotonic dystrophy with craniosynostosis.
Myotonic Dystrophy
HspB2/myotonic dystrophy protein kinase binding protein (MKBP) as a novel molecular chaperone: structural and functional aspects.
Myotonic Dystrophy
Human genome--chromosome no. 19.
Myotonic Dystrophy
Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake.
Myotonic Dystrophy
Human myotonic dystrophy protein kinase effect in S. cerevisiae.
Myotonic Dystrophy
Identification of a novel protein, DMAP, which interacts with the myotonic dystrophy protein kinase and shows strong homology to D1 snRNP.
Myotonic Dystrophy
Identification of intracellular signaling pathways that induce myotonic dystrophy protein kinase expression during myogenesis.
Myotonic Dystrophy
Identification of Intracellular Signaling Pathways that Induce Myotonic Dystrophy Protein Kinase Expression during Myogenesis.
Myotonic Dystrophy
Identification, tissue-specific expression, and subcellular localization of the 80- and 71-kDa forms of myotonic dystrophy kinase protein.
Myotonic Dystrophy
Immunocytochemical localization of myotonin protein kinase on muscle from patients with congenital myotonic dystrophy.
Myotonic Dystrophy
Immunolocalization of myotonic dystrophy protein kinase in corbular and junctional sarcoplasmic reticulum of human cardiac muscle.
Myotonic Dystrophy
Improved method for molecular diagnosis of myotonic dystrophy type 1 (DM1).
Myotonic Dystrophy
Independent regulation of the myotonic dystrophy 1 locus genes postnatally and during adult skeletal muscle regeneration.
Myotonic Dystrophy
Instability of normal (CTG)n alleles in the DM kinase gene.
Myotonic Dystrophy
Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha.
Myotonic Dystrophy
Investigation of molecular diagnosis in Chinese patients with myotonic dystrophy type 1.
Myotonic Dystrophy
Iraqi-Jewish kindreds with optic atrophy plus (3-methylglutaconic aciduria type 3) demonstrate linkage disequilibrium with the CTG repeat in the 3' untranslated region of the myotonic dystrophy protein kinase gene.
Myotonic Dystrophy
Lens epithelial changes and mutated gene expression in patients with myotonic dystrophy.
Myotonic Dystrophy
Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies.
Myotonic Dystrophy
Localization of myotonic dystrophy protein kinase in skeletal muscle and its alteration with disease.
Myotonic Dystrophy
Localization of the sites of conduction abnormalities in a mouse model of myotonic dystrophy.
Myotonic Dystrophy
Male hypogonadism in myotonic dystrophy is related to (CTG)n triplet mutation.
Myotonic Dystrophy
Mass spectrometry analysis of complexes formed by myotonic dystrophy protein kinase (DMPK).
Myotonic Dystrophy
Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy.
Myotonic Dystrophy
miR-322/miR-503 clusters regulate defective myoblast differentiation in myotonic dystrophy RNA-toxic by targeting Celf1.
Myotonic Dystrophy
MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase.
Myotonic Dystrophy
Molecular and clinical characteristics of myotonic dystrophy type 1 in koreans.
Myotonic Dystrophy
Molecular genetics of cardiomyopathies.
Myotonic Dystrophy
Molecular mechanisms of muscle atrophy in myotonic dystrophies.
Myotonic Dystrophy
Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1.
Myotonic Dystrophy
Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy.
Myotonic Dystrophy
Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation.
Myotonic Dystrophy
Myotonia congenita and myotonic dystrophy in the same family: coexistence of a CLCN1 mutation and expansion in the CNBP (ZNF9) gene.
Myotonic Dystrophy
Myotonic dystrophy (DM) protein kinase levels in congenital and adult DM patients.
Myotonic Dystrophy
Myotonic dystrophy and myotonic dystrophy protein kinase.
Myotonic Dystrophy
Myotonic dystrophy patients have larger CTG expansions in skeletal muscle than in leukocytes.
Myotonic Dystrophy
Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1.
Myotonic Dystrophy
Myotonic dystrophy protein kinase (DMPK) gene expression in lymphocytes of patients with myotonic dystrophy.
Myotonic Dystrophy
Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells.
Myotonic Dystrophy
Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface.
Myotonic Dystrophy
Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition.
Myotonic Dystrophy
Myotonic dystrophy protein kinase expressed in rat cardiac muscle is associated with sarcoplasmic reticulum and gap junctions.
Myotonic Dystrophy
Myotonic dystrophy protein kinase gene expression in skeletal muscle from congenitally affected infants.
Myotonic Dystrophy
Myotonic dystrophy protein kinase is critical for nuclear envelope integrity.
Myotonic Dystrophy
Myotonic dystrophy protein kinase is expressed in embryonic myocytes and is required for myotube formation.
Myotonic Dystrophy
Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells.
Myotonic Dystrophy
Myotonic dystrophy protein kinase monoclonal antibody generation from a coiled-coil template.
Myotonic Dystrophy
Myotonic dystrophy protein kinase of the cardiac muscle: evaluation using an immunochemical approach.
Myotonic Dystrophy
Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
Myotonic Dystrophy
Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.
Myotonic Dystrophy
Myotonic dystrophy: evidence for a possible dominant-negative RNA mutation.
Myotonic Dystrophy
Myotonic dystrophy: molecular and cellular consequences of expanded DNA repeats are elusive.
Myotonic Dystrophy
Myotonic dystrophy: molecular windows on a complex etiology.
Myotonic Dystrophy
Myotonic dystrophy: over-expression or/and under-expression? A critical review on a controversial point.
Myotonic Dystrophy
Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription.
Myotonic Dystrophy
Over expression of the murine myotonic dystrophy protein kinase in the mouse myogenic C2C12 cell line leads to inhibition of terminal differentiation.
Myotonic Dystrophy
Overexpression of 3'-untranslated region of the myotonic dystrophy kinase cDNA inhibits myoblast differentiation in vitro.
Myotonic Dystrophy
Overexpression of human myotonic dystrophy protein kinase in Schizosaccharomyces pombe induces an abnormal polarized and swollen cell morphology.
Myotonic Dystrophy
Overexpression of myotonic dystrophy kinase in BC3H1 cells induces the skeletal muscle phenotype.
Myotonic Dystrophy
Overexpression of myotonic dystrophy protein kinase in C2C12 myogenic culture involved in the expression of ferritin heavy chain and interleukin-1alpha mRNAs.
Myotonic Dystrophy
PDK1-mediated activation of MRCK? regulates directional cell migration and lamellipodia retraction.
Myotonic Dystrophy
Phospholemman is a substrate for myotonic dystrophy protein kinase.
Myotonic Dystrophy
Phosphorylation reactions of recombinant human myotonic dystrophy protein kinase and their inhibition.
Myotonic Dystrophy
Polymorphic CUG repeats in human mRNAs and their effects on gene expression.
Myotonic Dystrophy
Possible de novo CTG repeat expansion in the DMPK gene of a patient with cardiomyopathy.
Myotonic Dystrophy
Presence of palmar xanthomas in myotonic dystrophy identifies different patterns of linkage disequilibrium between the apolipoprotein E and myotonic dystrophy protein kinase loci.
Myotonic Dystrophy
Progressive atrioventricular conduction block in a mouse myotonic dystrophy model.
Myotonic Dystrophy
Progressive conduction disturbance in myotonic dystrophy.
Myotonic Dystrophy
Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase.
Myotonic Dystrophy
RARE POMC MUTATION IN A PATIENT WITH MYOTONIC DYSTROPHY TYPE 1 AND ADRENOCORTICOTROPIN HYPERRESPONSE TO CORTICOTROPIN-RELEASING HORMONE.
Myotonic Dystrophy
Re-entry circuit in ventricular tachycardia due to focal fatty-fibrosis in a patient with myotonic dystrophy.
Myotonic Dystrophy
Real-time RT-PCR for CTG repeat-containing genes.
Myotonic Dystrophy
Repair of myotonic dystrophy protein kinase (DMPK) transcripts by trans-splicing ribozymes.
Myotonic Dystrophy
Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy.
Myotonic Dystrophy
Ribozyme-catalyzed excision of targeted sequences from within RNAs.
Myotonic Dystrophy
Ribozyme-mediated trans-splicing of a trinucleotide repeat.
Myotonic Dystrophy
RNA metabolism in myotonic dystrophy: patient muscle shows decreased insulin receptor RNA and protein consistent with abnormal insulin resistance.
Myotonic Dystrophy
Role of Myotonic Dystrophy Protein Kinase (DMPK) in Glucose Homeostasis and Muscle Insulin Action.
Myotonic Dystrophy
Searching for candidate genes for male infertility.
Myotonic Dystrophy
Serum response factor regulates smooth muscle contractility via myotonic dystrophy protein kinases and L-type calcium channels.
Myotonic Dystrophy
Skeletal muscle Na currents in mice heterozygous for Six5 deficiency.
Myotonic Dystrophy
Skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase.
Myotonic Dystrophy
Somatic cell heterogeneity between DNA extracted from lymphocytes and skeletal muscle in congenital myotonic dystrophy.
Myotonic Dystrophy
Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.
Myotonic Dystrophy
Specific tau variants in the brains of patients with myotonic dystrophy.
Myotonic Dystrophy
Structural organization and developmental expression pattern of the mouse WD-repeat gene DMR-N9 immediately upstream of the myotonic dystrophy locus.
Myotonic Dystrophy
Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene.
Myotonic Dystrophy
Structure of dystrophia myotonica protein kinase.
Myotonic Dystrophy
Surgical repair for atrial septal defect associated with myotonic dystrophy.
Myotonic Dystrophy
Technical standards and guidelines for myotonic dystrophy type 1 testing.
Myotonic Dystrophy
The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy.
Myotonic Dystrophy
The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions.
Myotonic Dystrophy
The pleiotropic expression of the myotonic dystrophy protein kinase gene illustrates the complex relationships between genetic, biological and clinical covariates of male aging.
Myotonic Dystrophy
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
Myotonic Dystrophy
The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway.
Myotonic Dystrophy
Transcriptional properties of RNA polymerase II within triplet repeat-containing DNA from the human myotonic dystrophy and fragile X loci.
Myotonic Dystrophy
Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy.
Myotonic Dystrophy
Transient up-regulation of myotonic dystrophy protein kinase-binding protein, MKBP, and HSP27 in the neonatal myocardium.
Myotonic Dystrophy
Transmission ratio distortion and maternal effects confound the analysis of modulators of cystic fibrosis disease severity on 19q13.
Myotonic Dystrophy
Triplet-primed PCR is more sensitive than southern blotting-long PCR for the diagnosis of myotonic dystrophy type1.
Myotonic Dystrophy
Viral vector producing antisense RNA restores myotonic dystrophy myoblast functions.
Myotonic Dystrophy
Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein.
Myotonic Dystrophy
Woodchuck post-transcriptional element induces nuclear export of myotonic dystrophy 3' untranslated region transcripts.
Myotonic Dystrophy
[A case of dystrophia myotonica with homozygous DM kinase abnormalities]
Myotonic Dystrophy
[A genetic systemic disease: Clinical description of type 1 myotonic dystrophy in adults.]
Myotonic Dystrophy
[Clinical features and care of patients with congenital and childhood-onset myotonic dystrophy].
Myotonic Dystrophy
[Correlation between gene analysis and endocrine abnormalities in the patients with myotonic dystrophy]
Myotonic Dystrophy
[DNA diagnosis in myotonic dystrophy]
Myotonic Dystrophy
[Myotonic dystrophy - a new insight into a well-known disease]
Myotonic Dystrophy
[Oligosaccharide abnormalities and expansion of the CTG repeat of MT-PK gene in patients with myotonic dystrophy]
Myotonic Dystrophy
[The relationship between muscle pathology and DM kinase abnormalities in patients with dystrophia myotonica]
Myxoma
Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog.
Myxoma
Carney complex and McCune Albright syndrome: An overview of clinical manifestations and human molecular genetics.
Myxoma
Genetic testing of the family with a Carney-complex member leads to successful early removal of an asymptomatic atrial myxoma in the mother of the patient.
Myxoma
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
Myxoma
Identification of a PRKAR1A mutation (c.491_492delTG) in familial cardiac myxoma: A case report.
Myxoma
MEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics.
Myxoma
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Myxoma
Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas.
Myxoma
Multiple Recurrent Cardiac Myxomas with Protein Kinase A regulatory Subunit 1? Gene Mutation.
Myxoma
Mutation Analysis of PRKAR1A Gene in a Patient with Atrial Myxoma.
Myxoma
Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex.
Myxoma
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas" (Carney complex).
Myxoma
Oncolysis of canine tumor cells by myxoma virus lacking the serp2 gene.
Myxoma
Role of the serine-threonine kinase PAK-1 in myxoma virus replication.
Myxoma
Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report.
Myxoma
Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.
Myxoma
The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.
Myxoma
Tumors and the heart: molecular genetic advances.
nadh:ubiquinone reductase (h+-translocating) deficiency
Unregulated mitochondrial GSK3beta activity results in NADH: ubiquinone oxidoreductase deficiency.
nadph dehydrogenase (quinone) deficiency
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Nasal Polyps
1,8-cineol inhibits the Wnt/?-catenin signaling pathway through GSK-3 dephosphorylation in nasal polyps of chronic rhinosinusitis patients.
Nasal Polyps
Oxidative CaMKII as a potential target for inflammatory disease (Review).
Nasal Polyps
The kinase LRRK2 is differently expressed in chronic rhinosinusitis with and without nasal polyps.
Nasopharyngeal Carcinoma
Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Casein kinase 1?-dependent inhibition of Wnt/?-catenin selectively targets nasopharyngeal carcinoma and increases chemosensitivity.
Nasopharyngeal Carcinoma
Chronic cadmium exposure aggravates malignant phenotypes of nasopharyngeal carcinoma by activating the Wnt/?-catenin signaling pathway via hypermethylation of the casein kinase 1? promoter.
Nasopharyngeal Carcinoma
Circ-ABCB10 promotes growth and metastasis of nasopharyngeal carcinoma by upregulating ROCK1.
Nasopharyngeal Carcinoma
CircPSMC3 inhibits cell proliferation and induces cell apoptosis in nasopharyngeal carcinoma by downregulating ROCK1.
Nasopharyngeal Carcinoma
Circular RNA_LARP4 inhibits cell proliferation and invasion of nasopharyngeal carcinoma by repressing ROCK1.
Nasopharyngeal Carcinoma
Clinicopathological significance of ROCK1 and PIK3CA expression in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product.
Nasopharyngeal Carcinoma
Down-regulation of succinate dehydrogenase subunit B and up-regulation of pyruvate dehydrogenase kinase 1 predicts poor prognosis in recurrent nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Downregulation of lncRNA SNHG7 inhibits proliferation and invasion of nasopharyngeal carcinoma cells through repressing ROCK1.
Nasopharyngeal Carcinoma
EBV-LMP1 regulating AKT/mTOR signaling pathway and WWOX in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo.
Nasopharyngeal Carcinoma
Elevated HSP90 associates with expression of HIF-1? and p-AKT and is predictive of poor prognosis in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Expression of 14-3-3 sigma, cyclin-dependent kinases 2 and 4, p16, and Epstein-Barr nuclear antigen 1 in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Expression of DNA-PKcs and BRCA1 as prognostic indicators in nasopharyngeal carcinoma following intensity-modulated radiation therapy.
Nasopharyngeal Carcinoma
Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells.
Nasopharyngeal Carcinoma
High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients.
Nasopharyngeal Carcinoma
In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells.
Nasopharyngeal Carcinoma
Inactivation of 14-3-3 sigma by promoter methylation correlates with metastasis in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
miR-331-3p Inhibits Proliferation and Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Targeting elf4B-PI3K-AKT Pathway.
Nasopharyngeal Carcinoma
Positive effect of high RKIP expression on reduced distant metastasis by chemotherapy when combined with radiotherapy in locoregionally advanced nasopharyngeal carcinoma: a prospective study.
Nasopharyngeal Carcinoma
Prognostic value of phosphorylated Raf kinase inhibitory protein at serine 153 and its predictive effect on the clinical response to radiotherapy in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Prospective study of prognostic value of Raf kinase inhibitory protein and pretreatment plasma Epstein-Barr virus DNA for distant metastasis in locoregionally advanced nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Nasopharyngeal Carcinoma
Raf kinase inhibitor protein correlates with sensitivity of nasopharyngeal carcinoma to radiotherapy.
Nasopharyngeal Carcinoma
Reduction of RKIP expression promotes nasopharyngeal carcinoma invasion and metastasis by activating Stat3 signaling.
Nasopharyngeal Carcinoma
SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
STYK1 promotes Warburg effect through PI3K/AKT signaling and predicts a poor prognosis in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Targeted proteomic analysis of 14-3-3 sigma in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines.
Nasopharyngeal Carcinoma
The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
The effect of functional MAPKAPK2 copy number variation CNV-30450 on elevating nasopharyngeal carcinoma risk is modulated by EBV infection.
Nasopharyngeal Carcinoma
TNF-? up-regulates cellular inhibitor of apoptosis protein 2 (c-IAP2) via c-Jun N-terminal kinase (JNK) pathway in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle, c-Jun N-terminal kinase and the cyclin D1 promoter.
Nasopharyngeal Carcinoma
[Association between single nucleotide polymorphism locus rs189037 in the promoter of ATM gene and nasopharyngeal carcinoma susceptibility in Cantonese].
Nasopharyngeal Carcinoma
[Effect of DNA-PKcs Antisense Oligodeoxynucleotides on Radiosensitivity of Nasopharyngeal Carcinoma Cell Lines with Different p53 Function Statuses.]
Nasopharyngeal Carcinoma
[Effect of protein kinase CK2 gene silencing on radiosensitization in human nasopharyngeal carcinoma cells]
Nasopharyngeal Carcinoma
[Effects of basic fibroblast growth factor on protein kinase B activity and c-fos expression in CNE- I nasopharyngeal carcinoma cell line]
Nasopharyngeal Carcinoma
[Effects of Honokiol on proliferation, migration and invasion in nasopharyngeal carcinoma cells].
Nasopharyngeal Carcinoma
[Expression and Clinical Significance of DNA-PKcs in Nasopharyngeal Carcinoma.]
Nasopharyngeal Carcinoma
[Relationship between PTEN mutations and protein kinase B phosphorylation caused by insulin or recombinant human epidermal growth factor stimulation].
Nasopharyngeal Carcinoma
[The expression of PIK3CA in nasopharyngeal carcinoma].
Nasopharyngeal Neoplasms
A functional variant in CHK1 contributes to increased risk of nasopharyngeal carcinoma in a Han Chinese population.
Nasopharyngeal Neoplasms
A G-quadruplex ligand SYUIQ-5 induces autophagy by inhibiting the Akt-FOXO3a pathway in nasopharyngeal cancer cells.
Nasopharyngeal Neoplasms
LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer.
Nasopharyngitis
Blocking PI3K/Akt signaling attenuates metastasis of nasopharyngeal carcinoma cells through induction of mesenchymal-epithelial reverting transition.
Neoplasm Metastasis
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Neoplasm Metastasis
14-3-3 ? expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.
Neoplasm Metastasis
2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer.
Neoplasm Metastasis
?-Catulin drives metastasis by activating ILK and driving an ?v?3 integrin signaling axis.
Neoplasm Metastasis
A combination of tumor and molecular markers predicts a poor prognosis in lung adenocarcinoma.
Neoplasm Metastasis
A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ER?-positive breast cancer cells.
Neoplasm Metastasis
A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics.
Neoplasm Metastasis
A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.
Neoplasm Metastasis
A three gene-based risk score predicts prognosis of resected non-small-cell lung cancer.
Neoplasm Metastasis
Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.
Neoplasm Metastasis
Aberrant expression of STYK1 and E-cadherin confer a poor prognosis for pancreatic cancer patients.
Neoplasm Metastasis
Aberrant methylation profile of 14-3-3 sigma and its reduced transcription/expression levels in Chinese sporadic female breast carcinogenesis.
Neoplasm Metastasis
Activation of AKT signaling promotes epithelial-mesenchymal transition and tumor growth in colorectal cancer cells.
Neoplasm Metastasis
Activation of c-jun N-terminal kinase is associated with cell proliferation and shorter relapse-free period in superficial spreading malignant melanoma.
Neoplasm Metastasis
Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma.
Neoplasm Metastasis
AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.
Neoplasm Metastasis
AKIP1 promoted epithelial-mesenchymal transition of non-small-cell lung cancer via transactivating ZEB1.
Neoplasm Metastasis
AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review.
Neoplasm Metastasis
Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.
Neoplasm Metastasis
Alpha-enolase promotes gastric cancer cell proliferation and metastasis via regulating AKT signaling pathway.
Neoplasm Metastasis
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
Neoplasm Metastasis
AMPK-Independent LKB1 Activity Is Required for Efficient Epithelial Ovarian Cancer Metastasis.
Neoplasm Metastasis
Amplification of Thymosin Beta 10 and AKAP13 Genes in Metastatic and Aggressive Papillary Thyroid Carcinomas.
Neoplasm Metastasis
An IFN-?-stimulated ATF6-C/EBP-?-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy.
Neoplasm Metastasis
Analysis of possible mechanisms accounting for raf-1 kinase inhibitor protein downregulation in hepatocellular carcinoma.
Neoplasm Metastasis
Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway.
Neoplasm Metastasis
Anti-metastasis effect of fucoidan from Undaria pinnatifida sporophylls in mouse hepatocarcinoma Hca-F cells.
Neoplasm Metastasis
Anti-metastatic Effects of Cationic KT2 Peptide (a Lysine/Tryptophan-rich Peptide) on Human Melanoma A375.S2 Cells.
Neoplasm Metastasis
Antiproliferative effect of the methanol extract from the roots of Petasites japonicus on Hep3B hepatocellular carcinoma cells in vitro and in vivo.
Neoplasm Metastasis
ANXA1-GSK3? interaction and its involvement in NSCLC metastasis.
Neoplasm Metastasis
ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.
Neoplasm Metastasis
ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis.
Neoplasm Metastasis
Assessment of the methods used to detect HER2-positive advanced extramammary Paget's disease.
Neoplasm Metastasis
Association between ATM rs1801516 polymorphism and cancer susceptibility: a meta-analysis involving 12,879 cases and 18,054 controls.
Neoplasm Metastasis
Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer.
Neoplasm Metastasis
Association between raf kinase inhibitor protein loss and prognosis in cancers of the digestive system: a meta-analysis.
Neoplasm Metastasis
Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients.
Neoplasm Metastasis
Association of chromosome 19 to lung cancer genotypes and phenotypes.
Neoplasm Metastasis
Association of EGFR and KRAS mutations with expression of p-AKT, DR5 and DcR1 in non-small cell lung cancer.
Neoplasm Metastasis
Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
Neoplasm Metastasis
Ataxia-telangiectasia mutated interactor regulates head and neck cancer metastasis via KRas expression.
Neoplasm Metastasis
Aurora B expression in metastatic effusions from advanced-stage ovarian serous carcinoma is predictive of intrinsic chemotherapy resistance.
Neoplasm Metastasis
Autophagy flux inhibition, G2/M cell cycle arrest and apoptosis induction by ubenimex in glioma cell lines.
Neoplasm Metastasis
Beyond DNA Repair: DNA-PKcs in Tumor Metastasis, Metabolism and Immunity.
Neoplasm Metastasis
Biomarker-based treatment selection in early-stage rectal cancer to promote organ preservation.
Neoplasm Metastasis
Blocking PI3K/Akt signaling attenuates metastasis of nasopharyngeal carcinoma cells through induction of mesenchymal-epithelial reverting transition.
Neoplasm Metastasis
BRAF V600E Mutation Independently Predicts Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Cancer.
Neoplasm Metastasis
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis.
Neoplasm Metastasis
Breast Carcinoma-associated Fibroblasts Share Similar Biomarker Profiles in Matched Lymph Node Metastasis.
Neoplasm Metastasis
C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer.
Neoplasm Metastasis
c-Jun N-Terminal Kinases Mediate a Wide Range of Targets in the Metastatic Cascade.
Neoplasm Metastasis
C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits.
Neoplasm Metastasis
Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells.
Neoplasm Metastasis
Calcium/calmodulin?dependent protein kinase II enhances metastasis of human gastric cancer by upregulating nuclear factor??B and Akt?mediated matrix metalloproteinase?9 production.
Neoplasm Metastasis
Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors.
Neoplasm Metastasis
Casein kinase 1 (CK1) promotes the proliferation and metastasis of glioma cells via the phosphatidylinositol 3 kinase-matrix metalloproteinase 2 (AKT-MMP2) pathway.
Neoplasm Metastasis
Characterization of Aurora A and Its Impact on the Effect of Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer.
Neoplasm Metastasis
Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer.
Neoplasm Metastasis
Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity.
Neoplasm Metastasis
Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis.
Neoplasm Metastasis
Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor ?2.
Neoplasm Metastasis
Chk1 suppression leads to a reduction in the enhanced radiation-induced invasive capability on breast cancer cells.
Neoplasm Metastasis
Circ-ABCB10 promotes growth and metastasis of nasopharyngeal carcinoma by upregulating ROCK1.
Neoplasm Metastasis
Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblastoma by regulating ROCK1 expression.
Neoplasm Metastasis
Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3?.
Neoplasm Metastasis
Circular RNA_LARP4 inhibits cell proliferation and invasion of nasopharyngeal carcinoma by repressing ROCK1.
Neoplasm Metastasis
Circ_0009910 promotes proliferation and metastasis of hepatocellular carcinoma cells through miR-335-5p/ROCK1 axis.
Neoplasm Metastasis
CK2 Inhibitor CX-4945 Blocks TGF-?1-Induced Epithelial-to-Mesenchymal Transition in A549 Human Lung Adenocarcinoma Cells.
Neoplasm Metastasis
Clinical implication of Sox9 and activated Akt expression in pancreatic ductal adenocarcinoma.
Neoplasm Metastasis
Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer.
Neoplasm Metastasis
Clinical significance of raf-1 kinase inhibitor protein in oral squamous cell carcinoma and its role in cell metastasis.
Neoplasm Metastasis
Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
Neoplasm Metastasis
Clinical significance of serum 14-3-3 beta in patients with hepatocellular carcinoma.
Neoplasm Metastasis
Clinicopathological features and prognostic implications of Raf kinase inhibitor protein downregulation in tongue squamous cell carcinoma.
Neoplasm Metastasis
Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer.
Neoplasm Metastasis
cMET promotes metastasis and epithelial-mesenchymal transition in colorectal carcinoma by repressing RKIP.
Neoplasm Metastasis
Combined microRNA-340 and ROCK1 mRNA profiling predicts tumor progression and prognosis in pediatric osteosarcoma.
Neoplasm Metastasis
Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells.
Neoplasm Metastasis
Comparative proteome analysis of three mouse lung adenocarcinoma CMT cell lines with different metastatic potential by two-dimensional gel electrophoresis and mass spectrometry.
Neoplasm Metastasis
Complete Pathologic Response of Multiple Liver Metastases and Clinical Complete Response of Rectal Cancer in a Patient with Ataxia-Telangiectasia Mutated Gene Mutations After XELOXIRI Plus Bevacizumab: A Case Report.
Neoplasm Metastasis
Correlation of PRL3 expression with colorectal cancer progression.
Neoplasm Metastasis
CX-F9, a novel RSK2 inhibitor, suppresses cutaneous melanoma cells proliferation and metastasis through regulating autophagy.
Neoplasm Metastasis
Cyclic AMP responsive element-binding protein induces metastatic renal cell carcinoma by mediating the expression of matrix metallopeptidase-2/9 and proteins associated with epithelial-mesenchymal transition.
Neoplasm Metastasis
Cyclin G1-mediated epithelial-mesenchymal transition via PI3-K/Akt signaling facilitates liver cancer progression.
Neoplasm Metastasis
Cytoplasmic accumulation of glycogen synthase kinase-3beta is associated with aggressive clinicopathological features in human prostate cancer.
Neoplasm Metastasis
DAPK1 loss triggers tumor invasion in colorectal tumor cells.
Neoplasm Metastasis
DCAMKL1 is associated with the malignant status and poor outcome in bladder cancer.
Neoplasm Metastasis
Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions.
Neoplasm Metastasis
Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis.
Neoplasm Metastasis
Decreased expression and aberrant methylation of Raf kinase inhibitory protein gene in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas.
Neoplasm Metastasis
Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells.
Neoplasm Metastasis
Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients.
Neoplasm Metastasis
Differential expression of HER2 and downstream proteins in prediction of advanced tumor phenotypes and overall survival of patients with Epstein-Barr virus-positive vs. negative gastric cancers.
Neoplasm Metastasis
Dihydroartemisinin induces apoptosis of cervical cancer cells via upregulation of RKIP and downregulation of bcl-2.
Neoplasm Metastasis
Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas.
Neoplasm Metastasis
DNA-dependent protein kinase catalytic subunit functions in metastasis and influences survival in advanced-stage laryngeal squamous cell carcinoma.
Neoplasm Metastasis
DNA-PKcs and Ku70 are predictive markers for poor prognosis of patients with gall bladder malignancies.
Neoplasm Metastasis
DNA-PKcs Emerges as Master Driver of Metastasis.
Neoplasm Metastasis
DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-?1/Smad Signaling Pathway.
Neoplasm Metastasis
DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion.
Neoplasm Metastasis
DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.
Neoplasm Metastasis
Docosahexaenoic acid inhibits lipopolysaccharide-induced metastatic activities by decreasing inflammation on prostate cancer cell.
Neoplasm Metastasis
Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway.
Neoplasm Metastasis
Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4.
Neoplasm Metastasis
Downregulation of homeodomain-interacting protein kinase-2 contributes to bladder cancer metastasis by regulating Wnt signaling.
Neoplasm Metastasis
Downregulation of MicroRNA-152 and Inhibition of Cell Proliferation, Migration, and Invasion in Breast Cancer.
Neoplasm Metastasis
Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors.
Neoplasm Metastasis
Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.
Neoplasm Metastasis
Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer.
Neoplasm Metastasis
Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion events.
Neoplasm Metastasis
Dysregulation of mTOR activity through LKB1 inactivation.
Neoplasm Metastasis
Dysregulation of the cell survival/anti-apoptotic NF-kappaB pathway by the novel humanized BM-ca anti-CD20 mAb: implication in chemosensitization.
Neoplasm Metastasis
Effect of Raf kinase inhibitor protein expression on malignant biological behavior and progression of colorectal cancer.
Neoplasm Metastasis
Effects of raf kinase inhibitor protein expression on metastasis and progression of human breast cancer.
Neoplasm Metastasis
Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer.
Neoplasm Metastasis
Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: an in vivo and in vitro study.
Neoplasm Metastasis
Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis.
Neoplasm Metastasis
Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis.
Neoplasm Metastasis
Emerging functions of PRKDC in the initiation and progression of cancer.
Neoplasm Metastasis
Enah overexpression is correlated with poor survival and aggressive phenotype in gastric cancer.
Neoplasm Metastasis
Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.
Neoplasm Metastasis
Epigenetic changes and nuclear factor-?B activation, but not microRNA-224, downregulate Raf-1 kinase inhibitor protein in triple-negative breast cancer SUM 159 cells.
Neoplasm Metastasis
Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2.
Neoplasm Metastasis
Exploiting p70 S6 kinase as a target for ovarian cancer.
Neoplasm Metastasis
Expression and clinical significance of A-kinase anchor protein 4 in lung adenocarcinoma tissue.
Neoplasm Metastasis
Expression and clinical significance of the phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway in non-small cell lung carcinoma.
Neoplasm Metastasis
Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma.
Neoplasm Metastasis
Expression and significance of Twist, estrogen receptor, and E-cadherin in human breast cancer cells and tissues.
Neoplasm Metastasis
Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome.
Neoplasm Metastasis
Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.
Neoplasm Metastasis
Expression of DNA-PKcs and BRCA1 as prognostic indicators in nasopharyngeal carcinoma following intensity-modulated radiation therapy.
Neoplasm Metastasis
Expression of p-Akt in ovarian serous carcinoma and its association with proliferation and apoptosis.
Neoplasm Metastasis
Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis.
Neoplasm Metastasis
Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases.
Neoplasm Metastasis
Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer.
Neoplasm Metastasis
Expression of phosphorylated extracellular signal-regulated kinase at the invasive front of hepatic colorectal metastasis.
Neoplasm Metastasis
Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis.
Neoplasm Metastasis
Expression of Raf Kinase Inhibitor Protein (RKIP) is a predictor of uveal melanoma metastasis.
Neoplasm Metastasis
Expression of Raf kinase inhibitor protein in human hepatoma tissues by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight methods.
Neoplasm Metastasis
Expression of Raf kinase inhibitor protein is downregulated in response to Newcastle disease virus infection to promote viral replication.
Neoplasm Metastasis
FHL3 Contributes to EMT and Chemotherapy Resistance Through Up-Regulation of Slug and Activation of TGF?/Smad-Independent Pathways in Gastric Cancer.
Neoplasm Metastasis
Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B.
Neoplasm Metastasis
Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors.
Neoplasm Metastasis
Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression.
Neoplasm Metastasis
Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells.
Neoplasm Metastasis
Gamabufotalin suppressed osteosarcoma stem cells through the TGF-?/periostin/PI3K/AKT pathway.
Neoplasm Metastasis
Gefitinib Inhibits Invasion and Metastasis of Osteosarcoma via Inhibition of Macrophage Receptor Interacting Serine-Threonine Kinase 2.
Neoplasm Metastasis
Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients.
Neoplasm Metastasis
Gene sequencing and expression of Raf-1 in lymphatic metastasis of hypopharyngeal carcinoma.
Neoplasm Metastasis
Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.
Neoplasm Metastasis
Genome variation in colorectal cancer patient with liver metastasis measured by whole-exome sequencing.
Neoplasm Metastasis
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion.
Neoplasm Metastasis
Glycogen Synthase Kinase-3?: a novel therapeutic target for pancreatic cancer.
Neoplasm Metastasis
GSK-3: a multifaceted player in acute leukemias.
Neoplasm Metastasis
GSK-3? regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1?.
Neoplasm Metastasis
Head-to-head comparison of the impact of Aurora A, Aurora B, Repp86, CDK1, CDK2 and Ki67 expression in two of the most relevant gynaecological tumor entities.
Neoplasm Metastasis
Helicobacter pylori induces cell migration and invasion through casein kinase 2 in gastric epithelial cells.
Neoplasm Metastasis
Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo(-/-) mice.
Neoplasm Metastasis
HER4 promotes the growth and metastasis of osteosarcoma via the PI3K/AKT pathway.
Neoplasm Metastasis
HIF-1? and RKIP: a computational approach for pancreatic cancer therapy.
Neoplasm Metastasis
Hinokitiol reduces tumor metastasis by inhibiting heparanase via extracellular signal-regulated kinase and protein kinase B pathway.
Neoplasm Metastasis
HIPK2 inhibits cell metastasis and improves chemosensitivity in esophageal squamous cell carcinoma.
Neoplasm Metastasis
HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1?.
Neoplasm Metastasis
Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer.
Neoplasm Metastasis
Hypomethylation-activated cancer-testis gene SPANXC promotes cell metastasis in lung adenocarcinoma.
Neoplasm Metastasis
Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells.
Neoplasm Metastasis
Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5.
Neoplasm Metastasis
Identification of Aurora Kinase A as a Biomarker for Prognosis in Obesity Patients with Early Breast Cancer.
Neoplasm Metastasis
Identification of genes responsible for cell migration by a library of randomized ribozymes.
Neoplasm Metastasis
Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer.
Neoplasm Metastasis
Identification of novel metastasis suppressor signaling pathways for breast cancer.
Neoplasm Metastasis
Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities.
Neoplasm Metastasis
Identification of RKIP as an Invasion Suppressor Protein in Nasopharyngeal Carcinoma by Proteomic Analysis.
Neoplasm Metastasis
Identification of RKIP as an invasion suppressor protein in nasopharyngeal carcinoma by proteomic analysis.
Neoplasm Metastasis
Identification of Skt11-regulated genes in chondrocytes by integrated bioinformatics analysis.
Neoplasm Metastasis
ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway.
Neoplasm Metastasis
Immunohistochemical detection of Raf kinase inhibitor protein in normal cervical tissue and cervical cancer tissue.
Neoplasm Metastasis
Immunohistochemical detection of the Raf kinase inhibitor protein in nonneoplastic gastric tissue and gastric cancer tissue.
Neoplasm Metastasis
Immunohistochemical evaluation of ROCK activation in invasive breast cancer.
Neoplasm Metastasis
Improving the affinity of SL0101 for RSK using structure-based design.
Neoplasm Metastasis
Inactivation of 14-3-3 sigma by promoter methylation correlates with metastasis in nasopharyngeal carcinoma.
Neoplasm Metastasis
Inactivation of homeodomain-interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53-dependent E-cadherin expression.
Neoplasm Metastasis
Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma.
Neoplasm Metastasis
Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer.
Neoplasm Metastasis
Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer.
Neoplasm Metastasis
Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma.
Neoplasm Metastasis
Inflamed snail speeds metastasis.
Neoplasm Metastasis
Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway.
Neoplasm Metastasis
Inhibition of Cancer Invasion and Metastasis by Targeting the Molecular Chaperone Heat-shock Protein 90.
Neoplasm Metastasis
Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction.
Neoplasm Metastasis
Inhibition of phosphoinositide 3-kinase/Akt pathway decreases hypoxia inducible factor-1? expression and increases therapeutic efficacy of paclitaxel in human hypoxic gastric cancer cells.
Neoplasm Metastasis
Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice.
Neoplasm Metastasis
Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice.
Neoplasm Metastasis
Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma.
Neoplasm Metastasis
Integrin-linked kinase activity modulates the pro-metastatic behavior of ovarian cancer cells.
Neoplasm Metastasis
Interleukin 6 trigged ataxia-telangiectasia mutated activation facilitates lung cancer metastasis via MMP-3/MMP-13 up-regulation.
Neoplasm Metastasis
Inverse association between Bmi-1 and RKIP affecting clinical outcome of gastric cancer and revealing the potential molecular mechanisms underlying tumor metastasis and chemotherapy resistance.
Neoplasm Metastasis
Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome.
Neoplasm Metastasis
Inverse correlation between the metastasis suppressor RKIP and the metastasis inducer YY1: Contrasting roles in the regulation of chemo/immuno-resistance in cancer.
Neoplasm Metastasis
Investigational serine/threonine kinase inhibitors against prostate cancer metastases.
Neoplasm Metastasis
Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9.
Neoplasm Metastasis
ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways.
Neoplasm Metastasis
Killing two birds with one RKIP.
Neoplasm Metastasis
Kir2.1 interaction with Stk38 promotes invasion and metastasis of human gastric cancer by enhancing MEKK2-MEK1/2-ERK1/2 signaling.
Neoplasm Metastasis
Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGF?/CTGF Axis.
Neoplasm Metastasis
Knockdown of Rho-associated protein kinase 1 suppresses proliferation and invasion of glioma cells.
Neoplasm Metastasis
Knockdown of thrombospondin 2 inhibits metastasis through modulation of PI3K signaling pathway in uveal melanoma cell line M23.
Neoplasm Metastasis
Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.
Neoplasm Metastasis
LC-MS/MS Analysis of Ovarian Cancer Metastasis-Related Proteins Using a Nude Mouse Model: 14-3-3 Zeta as a Candidate Biomarker.
Neoplasm Metastasis
Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway.
Neoplasm Metastasis
Ligand binding study of human PEBP1/RKIP: interaction with nucleotides and Raf-1 peptides evidenced by NMR and mass spectrometry.
Neoplasm Metastasis
Limited inhibition of multiple nodes in a driver network blocks metastasis.
Neoplasm Metastasis
LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target.
Neoplasm Metastasis
Liquiritigenin Potentiates the Inhibitory Effects of Cisplatin on Invasion and Metastasis Via Downregulation MMP-2/9 and PI3 K/AKT Signaling Pathway in B16F10 Melanoma Cells and Mice Model.
Neoplasm Metastasis
LKB1 loss of function studied in vivo.
Neoplasm Metastasis
LKB1 regulated pathways in lung cancer invasion and metastasis.
Neoplasm Metastasis
Long non-coding RNA MALAT1 for promoting metastasis and proliferation by acting as a ceRNA of miR-144-3p in osteosarcoma cells.
Neoplasm Metastasis
Long Noncoding RNA HAGLROS Promotes Cell Invasion and Metastasis by Sponging miR-152 and Upregulating ROCK1 Expression in Osteosarcoma.
Neoplasm Metastasis
Long noncoding RNA LINC00941 promotes pancreatic cancer progression by competitively binding miR-335-5p to regulate ROCK1-mediated LIMK1/Cofilin-1 signaling.
Neoplasm Metastasis
Long Noncoding RNAs Coregulated by Annexin A7 and JNK in Hepatocellular Carcinoma Cells Identified by Whole-Genome Expression Profiling.
Neoplasm Metastasis
Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers.
Neoplasm Metastasis
Loss of mir-146a function in hormone-refractory prostate cancer.
Neoplasm Metastasis
Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations.
Neoplasm Metastasis
Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis.
Neoplasm Metastasis
Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer.
Neoplasm Metastasis
Loss of Raf-1 kinase inhibitor protein expression is associated with lymph node metastasis in papillary thyroid cancer.
Neoplasm Metastasis
Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer.
Neoplasm Metastasis
Loss of RKIP expression during the carcinogenic evolution of endometrial cancer.
Neoplasm Metastasis
Loss of RKIP expression is associated with poor survival in GISTs.
Neoplasm Metastasis
Low RKIP expression associates with poor prognosis in bladder cancer patients.
Neoplasm Metastasis
LRRK2 Is Associated with Recurrence-Free Survival in Intrahepatic Cholangiocarcinoma and Downregulation of LRRK2 Suppresses Tumor Progress In Vitro.
Neoplasm Metastasis
M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.
Neoplasm Metastasis
MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation.
Neoplasm Metastasis
MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer.
Neoplasm Metastasis
Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line.
Neoplasm Metastasis
MCU-dependent mitochondrial Ca(2+) inhibits NAD(+)/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells.
Neoplasm Metastasis
Melanoma metastases caught in the AKT.
Neoplasm Metastasis
Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer.
Neoplasm Metastasis
Metastasis suppressor genes: a role for raf kinase inhibitor protein (RKIP).
Neoplasm Metastasis
Metastasis suppressor microRNA-335 targets the formin family of actin nucleators.
Neoplasm Metastasis
Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
Neoplasm Metastasis
Methylation of death-associated protein kinase in ovarian carcinomas.
Neoplasm Metastasis
Micropillar arrays as potential drug screens: Inhibition of micropillar-mediated activation of the FAK-Src-paxillin signaling pathway by the CK2 inhibitor CX-4945.
Neoplasm Metastasis
MicroRNA 135a Suppresses Lymph Node Metastasis through Down-Regulation of ROCK1 in Early Gastric Cancer.
Neoplasm Metastasis
MicroRNA-124 (MiR-124) Inhibits Cell Proliferation, Metastasis and Invasion in Colorectal Cancer by Downregulating Rho-Associated Protein Kinase 1(ROCK1).
Neoplasm Metastasis
MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma.
Neoplasm Metastasis
MicroRNA-1280 inhibits invasion and metastasis by targeting ROCK1 in bladder cancer.
Neoplasm Metastasis
MicroRNA-133b/EGFR axis regulates esophageal squamous cell carcinoma metastases by suppressing anoikis resistance and anchorage-independent growth.
Neoplasm Metastasis
microRNA-138-5p as a Worse Prognosis Biomarker in Pediatric, Adolescent, and Young Adult Osteosarcoma.
Neoplasm Metastasis
MicroRNA-144 suppresses osteosarcoma growth and metastasis by targeting ROCK1 and ROCK2.
Neoplasm Metastasis
MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer.
Neoplasm Metastasis
microRNA-152 inhibits cell proliferation, migration and invasion in breast cancer.
Neoplasm Metastasis
MicroRNA-197 induces epithelial-mesenchymal transition and invasion through the downregulation of HIPK2 in lung adenocarcinoma.
Neoplasm Metastasis
MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells.
Neoplasm Metastasis
MicroRNA-28-5p inhibits the migration and invasion of gastric cancer cells by suppressing AKT phosphorylation.
Neoplasm Metastasis
MicroRNA-335 and its target Rock1 synergistically influence tumor progression and prognosis in osteosarcoma.
Neoplasm Metastasis
MicroRNA-340 inhibits invasion and metastasis by downregulating ROCK1 in breast cancer cells.
Neoplasm Metastasis
MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway.
Neoplasm Metastasis
MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1.
Neoplasm Metastasis
MicroRNA-552 Accelerates the Progression of Gastric Cancer by Targeting FOXO1 and Regulating PI3K/AKT Pathway.
Neoplasm Metastasis
MicroRNA-598 acts as an inhibitor in retinoblastoma through targeting E2F1 and regulating AKT pathway.
Neoplasm Metastasis
MicroRNA?299?5p inhibits cell metastasis in breast cancer by directly targeting serine/threonine kinase 39.
Neoplasm Metastasis
MicroRNAs associated with lung squamous cell carcinoma: New prognostic biomarkers and therapeutic targets.
Neoplasm Metastasis
miR-107 regulates growth and metastasis of gastric cancer cells via activation of the PI3K-AKT signaling pathway by down-regulating FAT4.
Neoplasm Metastasis
MiR-126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2-mediated PI3K/Akt signaling pathway.
Neoplasm Metastasis
miR-141-3p promotes proliferation and metastasis of nasopharyngeal carcinoma by targeting NME1.
Neoplasm Metastasis
MiR-144 Inhibits Tumor Growth and Metastasis in Osteosarcoma via dual-suppressing RhoA/ROCK1 Signaling Pathway.
Neoplasm Metastasis
MiR-145 suppresses cell proliferation and motility by inhibiting ROCK1 in hepatocellular carcinoma.
Neoplasm Metastasis
miR-146a Exerts Differential Effects on Melanoma Growth and Metastatization.
Neoplasm Metastasis
MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells.
Neoplasm Metastasis
miR-193a-3p inhibition of the Slug activator PAK4 suppresses non-small cell lung cancer aggressiveness via the p53/Slug/L1CAM pathway.
Neoplasm Metastasis
miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer.
Neoplasm Metastasis
MiR-199a targeting ROCK1 to affect kidney cell proliferation, invasion and apoptosis.
Neoplasm Metastasis
MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1.
Neoplasm Metastasis
miR-208-Induced Epithelial to Mesenchymal Transition of Pancreatic Cancer Cells Promotes Cell Metastasis and Invasion.
Neoplasm Metastasis
MiR-216a-5p act as a tumor suppressor, regulating the cell proliferation and metastasis by targeting PAK2 in breast cancer.
Neoplasm Metastasis
miR-335-5p inhibits TGF-?1-induced epithelial-mesenchymal transition in non-small cell lung cancer via ROCK1.
Neoplasm Metastasis
miR-506 suppresses neuroblastoma metastasis by targeting ROCK1.
Neoplasm Metastasis
MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1.
Neoplasm Metastasis
miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma.
Neoplasm Metastasis
MiR-566 mediates cell migration and invasion in colon cancer cells by direct targeting of PSKH1.
Neoplasm Metastasis
MiR-592 functions as a tumor suppressor in acute myeloid leukemia by targeting ROCK1 and predicts patients' prognosis.
Neoplasm Metastasis
miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1.
Neoplasm Metastasis
Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein.
Neoplasm Metastasis
Molecular mechanism of LKB1 in the invasion and metastasis of colorectal cancer.
Neoplasm Metastasis
Molecular pathways: Beta-adrenergic signaling in cancer.
Neoplasm Metastasis
MSK2 promotes proliferation and tumor formation in squamous cervical cancer via PAX8/RB-E2F1/cyclin A2 axis.
Neoplasm Metastasis
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
Neoplasm Metastasis
MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.
Neoplasm Metastasis
MYC is expressed in the stromal and epithelial cells of primary breast carcinoma and paired nodal metastases.
Neoplasm Metastasis
N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties.
Neoplasm Metastasis
NEAT1/miR-101-dependent Up-regulation of DNA-PKcs Enhances Malignant Behaviors of Pancreatic Ductal Adenocarcinoma Cells.
Neoplasm Metastasis
Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
Neoplasm Metastasis
Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression.
Neoplasm Metastasis
NOK/STYK1 promotes the genesis and remodeling of blood and lymphatic vessels during tumor progression.
Neoplasm Metastasis
Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy.
Neoplasm Metastasis
Nuclear Aurora kinase A triggers programmed death-ligand 1-mediated immune suppression by activating MYC transcription in triple-negative breast cancer.
Neoplasm Metastasis
Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma.
Neoplasm Metastasis
Oral Administration of Apigenin Inhibits Metastasis through AKT/P70S6K1/MMP-9 Pathway in Orthotopic Ovarian Tumor Model.
Neoplasm Metastasis
Organelle-derived acetyl-CoA promotes prostate cancer cell survival, migration, and metastasis via activation of calmodulin kinase II.
Neoplasm Metastasis
Overexpression of integrin-linked kinase (ILK) promotes glioma cell invasion and migration and down-regulates E-cadherin via the NF-?B pathway.
Neoplasm Metastasis
Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer.
Neoplasm Metastasis
Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis.
Neoplasm Metastasis
Overexpression of RKIP inhibits cell invasion in glioma cell lines through upregulation of miR-98.
Neoplasm Metastasis
Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.
Neoplasm Metastasis
Overview of Protein Kinase B Enzyme:a Potential Target for breast and Prostate Cancer.
Neoplasm Metastasis
p-Akt and its relationship with clinicopathological features and survival in oral squamous cell carcinoma: an immunohistochemical study.
Neoplasm Metastasis
p-AKT overexpression in primary renal cell carcinomas and their metastases.
Neoplasm Metastasis
p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/b1 integrin signaling activation.
Neoplasm Metastasis
p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells.
Neoplasm Metastasis
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Neoplasm Metastasis
PARP10 suppresses tumor metastasis through regulation of Aurora A activity.
Neoplasm Metastasis
Patterns of gene promoter methylation in squamous cell cancer of the head and neck.
Neoplasm Metastasis
Patterns of Innate or Acquired Resistance to Anticancer Drugs: Our Experience to Overcome It.
Neoplasm Metastasis
PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation.
Neoplasm Metastasis
PD-L1, PDK-1 and p-Akt are correlated in patients with papillary thyroid carcinoma.
Neoplasm Metastasis
PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer.
Neoplasm Metastasis
Pharmacological prevention of surgery-accelerated metastasis in an animal model of osteosarcoma.
Neoplasm Metastasis
Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer.
Neoplasm Metastasis
Phosphorylated Akt Expression as a Favorable Prognostic Factor for Patients Undergoing Curative Resection and Adjuvant Chemoradiotherapy for Proximal Extrahepatic Bile Duct Cancer.
Neoplasm Metastasis
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis.
Neoplasm Metastasis
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells.
Neoplasm Metastasis
Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis.
Neoplasm Metastasis
Physicochemical properties of novel protein kinase inhibitors in relation to their substrate specificity for drug transporters.
Neoplasm Metastasis
PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.
Neoplasm Metastasis
Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization.
Neoplasm Metastasis
Platelet-activating factor enhances tumor metastasis via the ROS-dependent protein kinase CK2-mediated NF-?B activation.
Neoplasm Metastasis
Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer.
Neoplasm Metastasis
Potential Oncogenic Role of the Papillary Renal Cell Carcinoma Gene in Non-Small Cell Lung Cancers.
Neoplasm Metastasis
Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy.
Neoplasm Metastasis
PRKAR2B-HIF-1? loop promotes aerobic glycolysis and tumour growth in prostate cancer.
Neoplasm Metastasis
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Neoplasm Metastasis
Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases.
Neoplasm Metastasis
Prognostic value of activated Akt expression in oral squamous cell carcinoma.
Neoplasm Metastasis
Prognostic Value of Raf Kinase Inhibitor Protein in Esophageal Squamous Cell Carcinoma.
Neoplasm Metastasis
Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.
Neoplasm Metastasis
Promoter methylation of Raf kinase inhibitory protein: A significant prognostic indicator for patients with gastric adenocarcinoma.
Neoplasm Metastasis
Prospective study of prognostic value of Raf kinase inhibitory protein and pretreatment plasma Epstein-Barr virus DNA for distant metastasis in locoregionally advanced nasopharyngeal carcinoma.
Neoplasm Metastasis
Protein kinase A regulates Lewis lung carcinoma adherence to extracellular matrix components and spontaneous metastasis.
Neoplasm Metastasis
Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.
Neoplasm Metastasis
Protein kinase D1 induced epithelial-mesenchymal transition and invasion in salivary adenoid cystic carcinoma via E-cadherin/Snail regulation.
Neoplasm Metastasis
Protein kinase D1 induces G1-phase cell-cycle arrest independent of Checkpoint kinases by phosphorylating Cell Division Cycle Phosphatase 25.
Neoplasm Metastasis
Protein Kinase D1 Is Increased in Tumor Tissue, Correlates With Advanced Tumor Features and Worse Prognosis of Non-Small Cell Lung Cancer.
Neoplasm Metastasis
Protein kinase D1 regulates subcellular localisation and metastatic function of metastasis-associated protein 1.
Neoplasm Metastasis
Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.
Neoplasm Metastasis
Protein kinase D2 contributes to TNF-?-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3?/?-catenin pathway in hepatocellular carcinoma.
Neoplasm Metastasis
Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases.
Neoplasm Metastasis
Protein phosphatases limit tumor motility.
Neoplasm Metastasis
Proteome of formalin-fixed paraffin-embedded pancreatic ductal adenocarcinoma and lymph node metastases.
Neoplasm Metastasis
Proteomic approach for identification of protein S-nitrosation in mouse gastric mucosa treated with S-nitrosoglutathione.
Neoplasm Metastasis
PTH-related protein upregulates integrin alpha6beta4 expression and activates Akt in breast cancer cells.
Neoplasm Metastasis
Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells.
Neoplasm Metastasis
Radiomics in Differentiated Thyroid Cancer and Nodules: Explorations, Application, and Limitations.
Neoplasm Metastasis
Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of the plasma membrane.
Neoplasm Metastasis
Raf Kinase Inhibitor Protein (RKIP) Blocks Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Breast and Prostate Cancer.
Neoplasm Metastasis
Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer.
Neoplasm Metastasis
Raf kinase inhibitor protein correlates with sensitivity of nasopharyngeal carcinoma to radiotherapy.
Neoplasm Metastasis
Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients.
Neoplasm Metastasis
Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells.
Neoplasm Metastasis
Raf kinase inhibitor protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix metalloproteinase 9 and upregulating tissue inhibitor of metalloproteinase 4 expression.
Neoplasm Metastasis
Raf kinase inhibitor protein mediated signaling inhibits invasion and metastasis of hepatocellular carcinoma.
Neoplasm Metastasis
Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice.
Neoplasm Metastasis
Raf kinase inhibitor protein regulation of raf and MAPK signaling.
Neoplasm Metastasis
Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3?.
Neoplasm Metastasis
Raf kinase inhibitor protein suppresses nuclear factor-?B-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression.
Neoplasm Metastasis
Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene.
Neoplasm Metastasis
Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.
Neoplasm Metastasis
Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer.
Neoplasm Metastasis
Raf Kinase Inhibitory Protein Down-Expression Exacerbates Hepatic Fibrosis In Vivo and In Vitro.
Neoplasm Metastasis
Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint.
Neoplasm Metastasis
Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.
Neoplasm Metastasis
Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor.
Neoplasm Metastasis
Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells.
Neoplasm Metastasis
Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.
Neoplasm Metastasis
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Neoplasm Metastasis
Reciprocal activation within a kinase effector complex: A mechanism for the persistence of molecular memory.
Neoplasm Metastasis
Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer.
Neoplasm Metastasis
Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
Neoplasm Metastasis
Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Reduced Raf-1 kinase inhibitor protein expression predicts less favorable outcomes in patients with hepatic colorectal metastasis.
Neoplasm Metastasis
Reduced RKIP expression levels are associated with frequent non-small cell lung cancer metastasis and STAT3 phosphorylation and activation.
Neoplasm Metastasis
Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer.
Neoplasm Metastasis
Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis.
Neoplasm Metastasis
Reduction of RKIP expression promotes nasopharyngeal carcinoma invasion and metastasis by activating Stat3 signaling.
Neoplasm Metastasis
Regulation of E2F Transcription Factor 3 by microRNA-152 Modulates Gastric Cancer Invasion and Metastasis.
Neoplasm Metastasis
Regulation of Lewis lung carcinoma invasion and metastasis by protein kinase A.
Neoplasm Metastasis
Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity.
Neoplasm Metastasis
Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation.
Neoplasm Metastasis
Research progress on proteasome subunits in regulating occurrence and development of hepatocellular carcinoma.
Neoplasm Metastasis
Resveratrol binds and activates RKIP protein in colorectal cancer.
Neoplasm Metastasis
Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial? mesenchymal transition via the AKT/GSK?3?/Snail signaling pathway.
Neoplasm Metastasis
RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma.
Neoplasm Metastasis
RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma.
Neoplasm Metastasis
RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis.
Neoplasm Metastasis
RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
Neoplasm Metastasis
RKIP expression associated with gastric cancer cell invasion and metastasis.
Neoplasm Metastasis
RKIP Inhibition in Cervical Cancer Is Associated with Higher Tumor Aggressive Behavior and Resistance to Cisplatin Therapy.
Neoplasm Metastasis
RKIp inhibits the migration and invasion of human prostate cancer PC-3M cells through regulation of extracellular matrix.
Neoplasm Metastasis
RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes.
Neoplasm Metastasis
RKIP suppresses the proliferation and invasion ofchoriocarcinoma cells through inhibiting the MAPK signaling pathway.
Neoplasm Metastasis
RKIP suppresses the proliferation and metastasis of breast cancer cell lines through up-regulation of miR-185 targeting HMGA2.
Neoplasm Metastasis
ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating the LATS2-JNK signaling pathway.
Neoplasm Metastasis
Rock2 stabilizes ?-catenin to promote tumor invasion and metastasis in colorectal cancer.
Neoplasm Metastasis
Role of Raf-kinase inhibitor protein in colorectal cancer and its regulation by hydroxycamptothecine.
Neoplasm Metastasis
Role of RKIP in human hepatic stellate cell proliferation, invasion, and metastasis.
Neoplasm Metastasis
Role of serine/threonine kinase 33 methylation in colorectal cancer and its clinical significance.
Neoplasm Metastasis
Roles of vimentin and 14-3-3 zeta/delta in the inhibitory effects of heparin on PC-3M cell proliferation and B16-F10-luc-G5 cells metastasis.
Neoplasm Metastasis
RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis.
Neoplasm Metastasis
Salmonella Impacts Tumor-Induced Macrophage Polarization, and Inhibits SNAI1-Mediated Metastasis in Melanoma.
Neoplasm Metastasis
Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
Neoplasm Metastasis
Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy.
Neoplasm Metastasis
Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment.
Neoplasm Metastasis
Silencing of advanced glycosylation and glycosylation and product-specific receptor (RAGE) inhibits the metastasis and growth of non-small cell lung cancer.
Neoplasm Metastasis
Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells.
Neoplasm Metastasis
Silencing of RIPK4 inhibits epithelial?mesenchymal transition by inactivating the Wnt/??catenin signaling pathway in osteosarcoma.
Neoplasm Metastasis
Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo.
Neoplasm Metastasis
Somatic STK11 and Concomitant STK11/KRAS Mutational Frequency in Stage IV Lung Adenocarcinoma Adrenal Metastases.
Neoplasm Metastasis
Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.
Neoplasm Metastasis
SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma.
Neoplasm Metastasis
SSeCKS metastasis-suppressing activity in MatLyLu prostate cancer cells correlates with vascular endothelial growth factor inhibition.
Neoplasm Metastasis
STK17B promotes the progression of ovarian cancer.
Neoplasm Metastasis
STK33 promotes the growth and progression of human pancreatic neuroendocrine tumour via activation of the PI3K/AKT/mTOR pathway.
Neoplasm Metastasis
STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation.
Neoplasm Metastasis
Stratifin accelerates progression of lung adenocarcinoma at an early stage.
Neoplasm Metastasis
STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.
Neoplasm Metastasis
STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.
Neoplasm Metastasis
STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.
Neoplasm Metastasis
STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling.
Neoplasm Metastasis
Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis.
Neoplasm Metastasis
Survey of Raf kinase inhibitor protein (RKIP) in multiple cancer types.
Neoplasm Metastasis
SUZ12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis.
Neoplasm Metastasis
Synthesis, characterization, and anticancer activity of two mixed ligand copper(ii) complexes by regulating the VEGF/VEGFR2 signaling pathway.
Neoplasm Metastasis
Targeted inhibition of mTOR signaling improves sensitivity of esophageal squamous cell carcinoma cells to cisplatin.
Neoplasm Metastasis
Targeted proteomic analysis of 14-3-3 sigma in nasopharyngeal carcinoma.
Neoplasm Metastasis
Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.
Neoplasm Metastasis
Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases.
Neoplasm Metastasis
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/?-catenin signaling pathway in cervical cancer.
Neoplasm Metastasis
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
Neoplasm Metastasis
Targeting Raf Kinase Inhibitory Protein Regulation and Function.
Neoplasm Metastasis
Targeting the RhoGTPase/ROCK pathway for the treatment of VHL/HIF pathway-driven cancers.
Neoplasm Metastasis
TGF? and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells.
Neoplasm Metastasis
The ATM rs189037 G>A polymorphism is associated with the risk and prognosis of gastric cancer in Chinese individuals: A case-control study.
Neoplasm Metastasis
The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein.
Neoplasm Metastasis
The CK2 inhibitor CX4945 reverses cisplatin resistance in the A549/DDP human lung adenocarcinoma cell line.
Neoplasm Metastasis
The Clinical Implications of RSK1-3 in Human Breast Cancer.
Neoplasm Metastasis
The clinicopathological and prognostic impact of 14-3-3 protein isoforms expression in human cholangiocarcinoma by immunohistochemistry.
Neoplasm Metastasis
The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells.
Neoplasm Metastasis
The effects of RKIP gene expression on the biological characteristics of human triple-negative breast cancer cells in vitro.
Neoplasm Metastasis
The expressions of Hedgehog and PI3K-AKT pathway components correlate with invasion and metastasis in hepatocellular carcinoma.
Neoplasm Metastasis
The Fascinating Effects of Baicalein on Cancer: A Review.
Neoplasm Metastasis
The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors.
Neoplasm Metastasis
The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network.
Neoplasm Metastasis
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.
Neoplasm Metastasis
The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.
Neoplasm Metastasis
The mechanisms of renin-angiotensin system in hepatocellular carcinoma: From the perspective of liver fibrosis, HCC cell proliferation, metastasis and angiogenesis, and corresponding protection measures.
Neoplasm Metastasis
The Metastasis Suppressor Protein Nme1 Is a Concentration-Dependent Modulator of Ca2+/Calmodulin-Dependent Protein Kinase II.
Neoplasm Metastasis
The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.
Neoplasm Metastasis
The nucleolar protein NIFK promotes cancer progression via CK1?/?-catenin in metastasis and Ki-67-dependent cell proliferation.
Neoplasm Metastasis
The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer.
Neoplasm Metastasis
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance.
Neoplasm Metastasis
The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.
Neoplasm Metastasis
The RhoA dependent anti-metastatic function of RKIP in breast cancer.
Neoplasm Metastasis
The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing.
Neoplasm Metastasis
The Role of B-RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF-?B/Snail/RKIP/PTEN Circuit.
Neoplasm Metastasis
The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment.
Neoplasm Metastasis
The Role of the Calcitonin Peptide Family in Prostate Cancer and Bone Metastasis.
Neoplasm Metastasis
Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes.
Neoplasm Metastasis
Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells.
Neoplasm Metastasis
Translating Nanomedicine to Comparative Oncology-the Case for Combining Zinc Oxide Nanomaterials with Nucleic Acid Therapeutic and Protein Delivery for Treating Metastatic Cancer.
Neoplasm Metastasis
Tumor suppressor RKIP inhibits prostate cancer cell metastasis and sensitizes prostate cancer cells to docetaxel treatment.
Neoplasm Metastasis
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.
Neoplasm Metastasis
UNC5D, suppressed by promoter hypermethylation, inhibits cell metastasis by activating death-associated protein kinase 1 in prostate cancer.
Neoplasm Metastasis
Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease.
Neoplasm Metastasis
Up-regulation of LIMK1 expression in prostate cancer is correlated with poor pathological features, lymph node metastases and biochemical recurrence.
Neoplasm Metastasis
Upregulation of histamine receptor H1 promotes tumor progression and contributes to poor prognosis in hepatocellular carcinoma.
Neoplasm Metastasis
Upregulation of LIMK1 Is Correlated With Poor Prognosis and Immune Infiltrates in Lung Adenocarcinoma.
Neoplasm Metastasis
Upregulation of long noncoding RNA TUG1 contributes to the development of laryngocarcinoma by targeting miR-145-5p/ROCK1 axis.
Neoplasm Metastasis
Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.
Neoplasm Metastasis
Upregulation of Stress-Induced Protein Kinase CK1 Delta is associated with a Poor Prognosis for patients with Hepatocellular Carcinoma.
Neoplasm Metastasis
Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma.
Neoplasm Metastasis
WF-536 inhibits metastatic invasion by enhancing the host cell barrier and inhibiting tumour cell motility.
Neoplasm Metastasis
Wip1 suppresses ovarian cancer metastasis through the ATM/AKT/Snail mediated signaling.
Neoplasm Metastasis
WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis.
Neoplasm Metastasis
Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis.
Neoplasm Metastasis
[Citron Rho-interacting serine/threonine kinase knockdown suppresses prostate cancer cell proliferation and metastasis by blocking Hippo-YAP pathway].
Neoplasm Metastasis
[Clinicopathological significance of expressions of DNA dependent protein kinase catalytic subunit and P16 in colorectal carcinoma]
Neoplasm Metastasis
[Correlation of p38 mitogen-activated protein kinase signal transduction pathway to uPA expression in breast cancer]
Neoplasm Metastasis
[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer]
Neoplasm Metastasis
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Neoplasm Metastasis
[Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]
Neoplasm Metastasis
[Expression of Raf kinase inhibitor protein and its significance in invasion and metastasis of hepatocellular carcinoma].
Neoplasm Metastasis
[Preliminary study of dihydroartemisin in inhibiting invasion and metastasis of hepatoma cells].
Neoplasm Metastasis
[Prognostic value of combined expression of Aurora A, p53 and p21 WAF1 in patients after curative resection of non-small cell lung cancer].
Neoplasm Metastasis
[Relationship between raf kinase inhibitor protein and metastasis of ovarian carcinoma]
Neoplasm Metastasis
[Relative analysis of OPN and its related signal molecules in hepatocellular carcinoma.]
Neoplasm Metastasis
[Research progress of suppressor gene PTEN].
Neoplasm Metastasis
[The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.]
Neoplasm Metastasis
[The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma]
Neoplasm Metastasis
[The relationship between PTEN expression and PI3K/AKT signal pathway in colon carcinoma]
Neoplasm Micrometastasis
Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression.
Neoplasm Micrometastasis
[Overexpression of 14-3-3 in primary gastric cancers and clinical application for the detection of micrometastases in the peritoneal cavity]
Neoplasm, Residual
Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation.
Neoplasm, Residual
Different Proteins Regulated Apoptosis, Proliferation and Metastasis of Lung Adenocarcinoma After Radiotherapy at Different Time.
Neoplasm, Residual
High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer.
Neoplasm, Residual
Liposomal Delivery of MicroRNA-7-Expressing Plasmid Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells.
Neoplasm, Residual
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
Neoplasms
"Jnking" atherosclerosis.
Neoplasms
"NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors."
Neoplasms
(-)-4-O-(4-O-?-D-glucopyranosylcaffeoyl) quinic acid exerts anti-tumour effects against uveal melanoma through PI3K/AKT pathway.
Neoplasms
(-)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo.
Neoplasms
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Neoplasms
(Secondary) solid tumors in thyroid cancer patients treated with the multi-kinase inhibitor sorafenib may present diagnostic challenges.
Neoplasms
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.
Neoplasms
1,3,4-Oxadiazoles: An emerging scaffold to target growth factors, enzymes and kinases as anticancer agents.
Neoplasms
14-3-3 ? is a new target up-regulated by transforming growth factor-?1 through a Smad3-dependent mechanism.
Neoplasms
14-3-3 ?: a potential biomolecule for cancer therapy.
Neoplasms
14-3-3 beta in the healthy and diseased male reproductive system.
Neoplasms
14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region.
Neoplasms
14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma.
Neoplasms
14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).
Neoplasms
14-3-3 mediated regulation of the tumor suppressor protein, RASSF1A.
Neoplasms
14-3-3 protein sigma isoform co-localizes with phosphorylated ?-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease.
Neoplasms
14-3-3 proteins and cancer biology.
Neoplasms
14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease.
Neoplasms
14-3-3 proteins as potential oncogenes.
Neoplasms
14-3-3 proteins as potential therapeutic targets.
Neoplasms
14-3-3 proteins in cell cycle regulation.
Neoplasms
14-3-3 proteins mediate an essential anti-apoptotic signal.
Neoplasms
14-3-3 Proteins Modulate the ETS Transcription Factor ETV1 in Prostate Cancer.
Neoplasms
14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila.
Neoplasms
14-3-3 Proteins--a focus on cancer and human disease.
Neoplasms
14-3-3 proteins: an important regulator of autophagy in diseases.
Neoplasms
14-3-3 Proteins: diverse functions in cell proliferation and cancer progression.
Neoplasms
14-3-3 proteins: do they have a role in human cancer?
Neoplasms
14-3-3 Proteins: Novel Pharmacological Targets in Neurodegenerative Diseases.
Neoplasms
14-3-3 proteins: regulators of numerous eukaryotic proteins.
Neoplasms
14-3-3 sigma and 14-3-3 zeta plays an opposite role in cell growth inhibition mediated by transforming growth factor-beta 1.
Neoplasms
14-3-3 sigma and p53 expression in gastric cancer and its clinical applications.
Neoplasms
14-3-3 sigma is a useful immunohistochemical marker for diagnosing ovarian granulosa cell tumors and steroid cell tumors.
Neoplasms
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
Neoplasms
14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.
Neoplasms
14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).
Neoplasms
14-3-3 zeta as novel molecular target for cancer therapy.
Neoplasms
14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling.
Neoplasms
14-3-3 zeta protein secreted by tumor associated monocytes/macrophages from ascites of epithelial ovarian cancer patients.
Neoplasms
14-3-3, an integrator of cell mechanics and cytokinesis.
Neoplasms
14-3-3: A Case Study in PPI Modulation.
Neoplasms
14-3-3? as a prognostic marker and therapeutic target for cancer.
Neoplasms
14-3-3? is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer.
Neoplasms
14-3-3? Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells by Modulating Expression of MMP2 and MMP9 through PI3K/Akt/NF-?B Pathway.
Neoplasms
14-3-3? silencing retards tongue squamous cell carcinoma progression by inhibiting cell survival and migration.
Neoplasms
14-3-3sigma controls mitotic translation to facilitate cytokinesis.
Neoplasms
14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence.
Neoplasms
14th International Workshop on Ataxia-Telangiectasia ATW2012.
Neoplasms
15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity.
Neoplasms
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia.
Neoplasms
1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2.
Neoplasms
2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles.
Neoplasms
2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.
Neoplasms
2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1.
Neoplasms
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.
Neoplasms
3'-hydroxy-4'-methoxy-?-methyl-?-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction.
Neoplasms
3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer.
Neoplasms
37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade.
Neoplasms
3D-QSAR and Molecular Docking Studies on 3-Anilino-4-Arylmaleimide Derivatives as Glycogen Synthase Kinase-3? Inhibitors.
Neoplasms
3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3beta inhibitors.
Neoplasms
4-Aminoethylamino-emodin - a novel potent inhibitor of GSK-3beta - acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin.
Neoplasms
4-HPR impairs bladder cancer cell migration and invasion by interfering with the Wnt5a/JNK and Wnt5a/MMP-2 signaling pathways.
Neoplasms
4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management.
Neoplasms
4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis.
Neoplasms
5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis.
Neoplasms
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.
Neoplasms
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
Neoplasms
53BP1 is limiting for nonhomologous end-joining in ATM-deficient cells subjected to oncogenic stress or radiation.
Neoplasms
7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ER?, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway.
Neoplasms
7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-?B, MMP2, and MMP9 Expression.
Neoplasms
8-chloro-cAMP enhances the growth inhibitory effect of cytotoxic drugs in human colon cancer cells.
Neoplasms
8-Chloro-cyclic AMP and protein kinase A I-selective cyclic AMP analogs inhibit cancer cell growth through different mechanisms.
Neoplasms
8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors.
Neoplasms
8-Cl-cAMP and PKA I-selective cAMP analogs effectively inhibit undifferentiated thyroid cancer cell growth.
Neoplasms
8-Cl-cAMP induces cell cycle-specific apoptosis in human cancer cells.
Neoplasms
?-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives.
Neoplasms
?-Boswellic acid, a bioactive substance used in food supplements, inhibits protein synthesis by targeting the ribosomal machinery.
Neoplasms
?-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths.
Neoplasms
?-Catulin drives metastasis by activating ILK and driving an ?v?3 integrin signaling axis.
Neoplasms
?-Lapachone Induces NQO1- and Oxidative Stress-Dependent Hsp90 Cleavage and Inhibits Tumor Growth and Angiogenesis.
Neoplasms
?-Opioid receptor signalling via PI3K/Akt pathway ameliorates lipopolysaccharide-induced acute respiratory distress syndrome.
Neoplasms
?3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo.
Neoplasms
A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.
Neoplasms
A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo.
Neoplasms
A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis.
Neoplasms
A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer.
Neoplasms
A cancer associated aurora-A mutant is mislocalised and misregulated due to loss of interaction with TPX2.
Neoplasms
A Case of Paratubal Serous Borderline Tumor Driven by a Somatic BRAF Mutation in an Adolescent Patient.
Neoplasms
A case of Peutz-Jeghers syndrome with breast cancer, bilateral sex cord tumor with annular tubules, and adenoma malignum caused by STK11 gene mutation.
Neoplasms
A case of synchronous mucinous metaplasia and neoplasia of the female genital tract without an STK11 or KRAS mutation.
Neoplasms
A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'.
Neoplasms
A centrosomal route for cancer genome instability.
Neoplasms
A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway.
Neoplasms
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
Neoplasms
A classical PKA inhibitor increases the oncolytic effect of M1 virus via activation of exchange protein directly activated by cAMP 1.
Neoplasms
A combination of tumor and molecular markers predicts a poor prognosis in lung adenocarcinoma.
Neoplasms
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors.
Neoplasms
A Comparative Proteomic Analysis of Erinacine A's Inhibition of Gastric Cancer Cell Viability and Invasiveness.
Neoplasms
A comparative study of glycoproteomes in androgen-sensitive and -independent prostate cancer cell lines.
Neoplasms
A comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors.
Neoplasms
A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.
Neoplasms
A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer.
Neoplasms
A Comprehensive Repertoire of Transfer RNA-Derived Fragments and Their Regulatory Networks in Colorectal Cancer.
Neoplasms
A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer.
Neoplasms
A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.
Neoplasms
A consensus cAMP-dependent protein kinase (PK-A) site in place of the CcN motif casein kinase II site simian virus 40 large T-antigen confers PK-A-mediated regulation of nuclear import.
Neoplasms
A correlation analysis between tumor imaging changes and p-AKT and HSP70 expression in tumor cells after osteosarcoma chemotherapy.
Neoplasms
A correlation study of the expression of HA-CD44st and HER-2 in breast cancer.
Neoplasms
A cross-link between protein kinase A and Rho-family GTPases signaling mediates cell-cell adhesion and actin cytoskeleton organization in epithelial cancer cells.
Neoplasms
A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.
Neoplasms
A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase.
Neoplasms
A Distinctive Adnexal (Usually Paratubal) Neoplasm Often Associated With Peutz-Jeghers Syndrome and Characterized by STK11 Alterations (STK11 Adnexal Tumor): A Report of 22 Cases.
Neoplasms
A Double-Blind Randomized Discontinuation Phase-II Study of Sorafenib (BAY 43-9006) in Previously Treated Non-Small-Cell Lung Cancer Patients: Eastern Cooperative Oncology Group Study E2501.
Neoplasms
A first-in-human phase 1 and pharmacological study of TAS-119, a novel selective Aurora A kinase inhibitor in patients with advanced solid tumours.
Neoplasms
A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer.
Neoplasms
A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease.
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A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications.
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A Functional Cancer Genomics Screen Identifies a Druggable Synthetic Lethal Interaction between MSH3 and PRKDC.
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A Functional Copy-Number Variation in MAPKAPK2 Predicts Risk and Prognosis of Lung Cancer.
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A functional variant in CHK1 contributes to increased risk of nasopharyngeal carcinoma in a Han Chinese population.
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A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes.
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A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression.
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A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response.
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A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice.
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A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1.
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A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells.
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A homogenous luminescent proximity assay for 14-3-3 interactions with both phosphorylated and nonphosphorylated client peptides.
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A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth.
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A Jnk-Rho-Actin remodeling positive feedback network directs Src-driven invasion.
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A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells.
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A kinase-independent function for AURORA-A in replisome assembly during DNA replication initiation.
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A mathematical model of kinetochore-microtubule attachment regulated by Aurora A activity gradient describes chromosome oscillation and correction of erroneous attachments.
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A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.
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A Meta-Regression Method for Studying Etiological Heterogeneity Across Disease Subtypes Classified by Multiple Biomarkers.
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A microRNA profile of pediatric glioblastoma: The role of NUCKS1 upregulation.
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A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286.
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A monoclonal antibody which identifies the autophosphorylation domain of autophosphorylating protein kinase 500.
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A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
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A multi-targeted approach to suppress tumor-promoting inflammation.
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A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation.
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A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.
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A New Chemical Probe Challenges the Broad Cancer Essentiality of CK2.
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A new mechanism for LKB1 activation.
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A New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance.
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A noncanonical Flt3ITD/NF-?B signaling pathway represses DAPK1 in acute myeloid leukemia.
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A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.
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A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2? Complex Structures.
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A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level.
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A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish.
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A novel cancer testis antigen target A-kinase anchor protein (AKAP4) for the early diagnosis and immunotherapy of colon cancer.
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A Novel Cancer Testis Antigen, A-Kinase Anchor Protein 4 (AKAP4) Is a Potential Biomarker for Breast Cancer.
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A Novel Cell-Based, High-Content Assay for Phosphorylation of Lats2 by Aurora A.
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A novel class of selective CK2 inhibitors targeting its open hinge conformation.
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A novel cyclic adenosine monophosphate analog induces hypercalcemia via production of 1,25-dihydroxyvitamin D in patients with solid tumors.
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A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway.
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A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
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A novel evodiamine amino derivative as a PI3K/AKT signaling pathway modulator that induces apoptosis in small cell lung cancer cells.
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A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.
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A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization.
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A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.
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A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells.
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A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/?-catenin signaling in breast cancer.
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A novel pathogenic splice site variation in STK11 gene results in Peutz-Jeghers syndrome.
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A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors.
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A Novel Protein Fraction from Sesbania grandiflora Shows Potential Anticancer and Chemopreventive Efficacy, in vitro and in vivo.
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A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migration.
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A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation.
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A novel regulatory mechanism of Pim-3 kinase stability and its involvement in pancreatic cancer progression.
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A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells.
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A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.
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A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.
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A novel role for Wnt/Ca2+ signaling in actin cytoskeleton remodeling and cell motility in prostate cancer.
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A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
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A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
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A novel system to investigate the phosphorylation of the p53 tumor suppressor protein by the protein kinase CK2.
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A Novel Tropomyosin-Related Kinase A Inhibitor, KK5101 to Treat Pancreatic Cancer.
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A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.
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A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.
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A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation.
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A patent review of RAF kinase inhibitors (2010-2018).
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A patent update on PDK1 inhibitors (2015-present).
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A PEF/Y substrate recognition and signature motif plays a critical role in DAPK-related kinase activity.
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A peptide array-based serological protein kinase A activity assay and its application in cancer diagnosis.
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A phase 1 dose-escalation study of checkpoint kinase 1 (CHK1) inhibitor prexasertib in combination with p38 mitogen-activated protein kinase (p38 MAPK) inhibitor ralimetinib in patients with advanced or metastatic cancer.
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A Phase 1 Study of mTORC1/2 Inhibitor BI 860585 as a Single Agent or with Exemestane or Paclitaxel in Patients with Advanced Solid Tumors.
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A Phase 2 Cancer Chemoprevention Biomarker Trial of Isoflavone G-2535 (Genistein) in Presurgical Bladder Cancer Patients.
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A phase I clinical and pharmacokinetic study of the Raf kinase inhibitor (RKI) BAY 43-9006 administered in combination with doxorubicin in patients with solid tumors.
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A phase I safety and dose escalation trial of docetaxel combined with GEM((R))231, a second generation antisense oligonucleotide targeting protein kinase A R1alpha in patients with advanced solid cancers.
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A phase I safety and dose escalation trial of docetaxel combined with GEM231, a second generation antisense oligonucleotide targeting protein kinase A R1alpha in patients with advanced solid cancers.
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A phase I study of MK-5108, an oral aurora a kinase inhibitor, administered both as monotherapy and in combination with docetaxel, in patients with advanced or refractory solid tumors.
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A phase I study of the anaplastic lymphoma kinase inhibitor ceritinib in combination with gemcitabine-based chemotherapy in patients with advanced solid tumors.
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A Phase I Trial and Pharmacokinetic Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib in Children with Refractory Solid Tumors or Refractory Leukemias.
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A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours.
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A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer.
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A phase II pharmacodynamic study of erlotinib in patients with advanced non-small cell lung cancer previously treated with platinum-based chemotherapy.
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A Phase II Single Arm Pilot Study of the CHK1 Inhibitor Prexasertib (LY2606368) in BRCA Wild-Type, Advanced Triple-Negative Breast Cancer.
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A phase II study of everolimus in patients with advanced solid malignancies with TSC1, TSC2, NF1, NF2 or STK11 mutations.
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A Phase II Trial of Perifosine, An Oral Alkylphospholipid, In Recurrent or Metastatic Head and Neck Cancer.
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A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation.
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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
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A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation.
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A polymorphism in the ATM gene modulates the penetrance of hereditary non-polyposis colorectal cancer.
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A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.
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A potential role of nuclear matrix-associated protein kinase CK2 in protection against drug-induced apoptosis in cancer cells.
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A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1.
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A prospective multicenter phase II study on the efficacy and safety of dasatinib in the treatment of metastatic gastrointestinal stromal tumors failed by imatinib and sunitinib and analysis of NGS in peripheral blood.
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A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis.
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A proteomic approach of pediatric astrocytomas: MiRNAs and network insight.
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A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.
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A Pyloric Gland-Phenotype Ovarian Mucinous Tumor Resembling Lobular Endocervical Glandular Hyperplasia in a Patient with Peutz-Jeghers Syndrome.
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A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status.
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A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.
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A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma.
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A recent application of fluoro-18-deoxyglucose positron emission tomography, treatment monitoring with a mammalian target of rapamycin inhibitor: an example of a patient with a desmoplastic small round cell tumor.
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A regulatory feedback loop between HIF-1? and PIM2 in HepG2 cells.
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A Rising Cancer Prevention Target of RSK2 in Human Skin Cancer.
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A robust, target-driven, cell-based assay for checkpoint kinase 1 inhibitors.
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A safety study of a mixed-backbone oligonucleotide (GEM231) targeting the type I regulatory subunit alpha of protein kinase A using a continuous infusion schedule in patients with refractory solid tumors.
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A Screen for PKN3 Substrates Reveals an Activating Phosphorylation of ARHGAP18.
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A selective Akt inhibitor produces hypotension and bradycardia in conscious rats due to inhibition of the autonomic nervous system.
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A selective small-molecule inhibitor of c-Jun N-terminal kinase 1.
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A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.
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A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.
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A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.
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A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas.
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A specific inhibitor of protein kinase CK2 delays gamma-H2Ax foci removal and reduces clonogenic survival of irradiated mammalian cells.
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A subnanomolar fluorescent probe for protein kinase CK2 interaction studies.
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A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis.
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A Supramolecular Stabilizer of the 14-3-3?/ER? Protein-Protein Interaction with a Synergistic Mode of Action.
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A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients.
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A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation.
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A targeted library screen reveals a new inhibitor scaffold for protein kinase D.
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A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma.
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A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function.
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A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
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A tumor of the uterine cervix with a complex histology in a Peutz-Jeghers syndrome patient with genomic deletion of the STK11 exon 1 region.
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A vector-based short hairpin RNA targeting Aurora A inhibits breast cancer growth.
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A versatile modular vector set for optimizing protein expression among bacterial, yeast, insect and mammalian hosts.
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A-kinase anchoring protein 12 is downregulated in human hepatocellular carcinoma and its deficiency in mice aggravates thioacetamide-induced liver injury.
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A-kinase anchoring protein 12 regulates the completion of cytokinesis.
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A-kinase anchoring protein 2 is required for calcitonin-mediated invasion of cancer cells.
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A-Kinase Anchoring Proteins 10 Expression in Relation to 2073A/G Polymorphism and Tumor Progression in Patients with Colorectal Cancer.
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A-kinase interacting protein 1 (AKIP1) associates with advanced overall disease condition, tumor properties, and unfavorable prognosis in hepatocellular carcinoma patients.
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A-kinase interacting protein 1 as a potential biomarker of advanced tumor features and increased recurrence risk in papillary thyroid carcinoma patients.
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A-kinase interacting protein 1 high expression correlates with advanced tumor stage and poor overall survival in surgical patients with clear cell renal cell carcinoma.
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A-kinase interacting protein 1 is sufficiently expressed and positively associates with WHO grade, meanwhile predicts unfavorable overall survival independently in glioma patients.
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A-kinase interacting protein 1, a potential biomarker associated with advanced tumor features and CXCL1/2 in prostate cancer.
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A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.
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AbCD133 Modified ?CT1 Loaded Target Magnetic Mesoporous Silica Nano-Drugcarriers Can Sensitizes Glioma Cancer Stem Cells to TMZ and Have Therapeutic Potential on TMZ Resistant Glioblastoma.
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Aberrant expression of glycogen synthase kinase-3? in human breast and head and neck cancer.
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Aberrant expression of miR-21, miR-376c and miR-145 and their target host genes in Merkel cell polyomavirus-positive non-small cell lung cancer.
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Aberrant glycogen synthase kinase 3? in the development of pancreatic cancer.
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Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt.
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Aberrant methylation and loss expression of RKIP is associated with tumor progression and poor prognosis in gastric cardia adenocarcinoma.
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Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes.
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Aberrant Methylation of Death-Associated Protein Kinase 1 CpG Islands in Myelodysplastic Syndromes.
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Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia.
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Aberrant methylation of the death-associated protein kinase 1 (DAPK1) CpG island in chronic myeloid leukemia.
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Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.
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Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens.
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Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1.
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Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma.
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Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.
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Aberrations of the CHK2 gene are rare in pediatric solid tumors.
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Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.
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Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation.
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Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project.
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Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha.
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Acid-Induced Acute Lung Injury in Mice Associates with p44/42 and c-Jun N-Terminal Kinase Activation and Requires the Function of Tumor Necrosis Factor-? Receptor I.
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Acidic pH induces topoisomerase II-mediated DNA damage.
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Actein induces apoptosis in leukemia cells through suppressing RhoA/ROCK1 signaling pathway.
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ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells.
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Action of cAMP on expression and release of adhesion molecules in human endothelial cells.
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Activated Akt and Erk Expression and Survival After Surgery in Pancreatic Carcinoma.
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Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma.
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Activated Akt expression has significant correlation with EGFR and TGF-alpha expressions in stage I NSCLC.
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Activated Akt-1 in specific cell populations during multi-stage skin carcinogenesis.
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Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages.
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Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.
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Activated PI3K/Akt/COX-2 pathway induces resistance to radiation in human cervical cancer HeLa cells.
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Activated protein C, an anticoagulant polypeptide, ameliorates severe acute pancreatitis via regulation of mitogen-activated protein kinases.
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Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.
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Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity.
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Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients.
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Activating ROCK1 somatic mutations in human cancer.
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Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic.
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Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
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Activation of AKT in feline mammary carcinoma: A new prognostic factor for feline mammary tumours.
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Activation of AKT signaling promotes epithelial-mesenchymal transition and tumor growth in colorectal cancer cells.
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Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion.
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Activation of Akt/mTOR pathway in a patient with atypical teratoid/rhabdoid tumor.
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Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.
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Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas.
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Activation of c-Jun N-terminal kinase in the absence of NFkappaB function prior to induction of NK cell death triggered by a combination of anti-class I and anti-CD16 antibodies.
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Activation of caspase cascades in Korean mistletoe (Viscum album var. coloratum) lectin-II-induced apoptosis of human myeloleukemic U937 cells.
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Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis.
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Activation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.
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Activation of death-associated protein kinase 1 promotes neutrophil apoptosis to accelerate inflammatory resolution in acute respiratory distress syndrome.
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Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus.
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Activation of EGFR-Aurora A induces loss of primary cilia in oral squamous cell carcinoma.
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Activation of Epac alleviates inflammation and vascular leakage in LPS-induced acute murine lung injury.
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Activation of epidermal akt by diverse mouse skin tumor promoters.
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Activation of estrogen receptor ? by raloxifene through an activating protein-1-dependent tethering mechanism in human cervical epithelial cancer cells: a role for c-Jun N-terminal kinase.
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Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells.
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Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy.
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Activation of membrane androgen receptors in colon cancer inhibits the pro-survival signals Akt/Bad in vitro and in vivo and blocks migration via vinculin/actin signaling.
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Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process.
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Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition.
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Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis.
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Activation of mTOR/I?B-?/NF-?B pathway contributes to LPS-induced hypotension and inflammation in rats.
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Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.
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Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells.
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Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells.
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Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells.
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Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP.
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Activation of phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling and the consequent induction of transformation by overexpressed 14-3-3? protein require specific amino acids within 14-3-3? N-terminal variable region II.
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Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival.
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Activation of PI3K is associated with reduced survival in renal cell carcinoma.
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Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion.
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Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells.
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Activation of Raf kinase by phorbol ester does not correlate with enhanced phosphorylation or transactivation activity of tumor suppressor protein p53.
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Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-kappaB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway.
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Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis.
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Activation of the c-Jun N-terminal kinase/stress-activated protein kinase pathway by overexpression of caspase-8 and its homologs.
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Activation of the cAMP pathway in Ustilago maydis reduces fungal proliferation and teliospore formation in plant tumors.
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Activation of the Chicken Anemia Virus Apoptin protein by Chk1/2 phosphorylation is required for apoptotic activity and efficient viral replication.
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Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
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Activation of the mammalian target of rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics.
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Activation of the mTOR signaling pathway in breast cancer and its correlation with the clinicopathologic variables.
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Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions.
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Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma.
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Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia.
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Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia.
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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
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Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma.
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Activity of the Raf kinase inhibitor BAY 43-9006 in patients with advanced solid tumors.
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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
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Acute ethanol intoxication suppresses pentraxin 3 expression in a mouse sepsis model involving cecal ligation and puncture.
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Acute Megakaryoblastic Leukemia with Myelodysplasia-related Changes Associated with ATM Gene Deletion.
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ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistance.
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Addiction to elevated insulin-like growth factor i receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody.
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Addiction to protein kinase CK2: A common denominator of diverse cancer cells?
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Adenomyoepitheliomas of the Breast Frequently Harbor Recurrent Hotspot Mutations in PIK3-AKT Pathway-related Genes and a Subset Show Genetic Similarity to Salivary Gland Epithelial-Myoepithelial Carcinoma.
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Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis.
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Adenosine Monophosphate-Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection.
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Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice.
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Adenovirus-mediated Aurora A shRNA driven by stathmin promoter suppressed tumor growth and enhanced paclitaxel chemotherapy sensitivity in human breast carcinoma cells.
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Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.
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Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10.
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ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells.
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Advancement in TPL2-regulated innate immune response.
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Advances in the Researches on the Biological Activities and Inhibitors of Phosphatidylinositol 3-Kinase.
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Advances in understanding the molecular underpinnings of adrenocortical tumors.
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Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
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Adverse Cerebral Cardiovascular Events Associated With Checkpoint Kinase 1 Inhibitors: A Systemic Review.
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Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers.
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Aerobic exercise suppresses hepatocellular carcinoma by downregulating dynamin-related protein 1 through PI3K/AKT pathway.
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AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling.
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AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma.
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Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples.
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AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
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Airborne particulate matter in vitro exposure induces cytoskeleton remodeling through activation of the ROCK-MYPT1-MLC pathway in A549 epithelial lung cells.
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AKAP12, a gene with tumour suppressor properties, is a target of promoter DNA methylation in childhood myeloid malignancies.
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Akt activation by insulin treatment attenuates cachexia in Walker-256 tumor-bearing rats.
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AKT activation controls cell survival in response to HDAC6 inhibition.
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Akt activation correlates with adverse outcome in tongue cancer.
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Akt Activation Correlates with Snail Expression and Potentially Determines the Recurrence of Prostate Cancer in Patients at Stage T2 after a Radical Prostatectomy.
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Akt activation correlates with the tumor aggressiveness in Tunisian patients with bladder cancer.
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Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner.
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Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol.
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Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins.
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Akt controls vascular smooth muscle cell proliferation in vitro and in vivo by delaying G1/S exit.
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Akt expression may predict favorable prognosis in cholangiocarcinoma.
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Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition.
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Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression.
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AKT Inhibitors: The Road Ahead to Computational Modeling-Guided Discovery.
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AKT inhibits the phosphorylation level of H2A at Tyr57 via CK2? to promote the progression of gastric cancer.
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Akt is negatively regulated by the MULAN E3 ligase.
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Akt isoform specific effects in ovarian cancer progression.
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Akt isoforms and glucose homeostasis - the leptin connection.
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Akt pathway as a target for therapeutic intervention in HNSCC.
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Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.
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Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer.
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AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.
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Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.
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AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer.
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AKT/GSK-3 Pathway targeting; Botanicals and Bioactive Compounds with Anticancer Activities.
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Akt/p27kip1 Pathway Is Not Involved in Human Insulinoma Tumorigenesis.
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Akt/PKB signaling in cancer: a function in cell motility and invasion.
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AKT/protein kinase B associates with ?-actin in the nucleus of melanoma cells.
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Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells.
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AKT1 loss correlates with episomal HPV16 in vulval intraepithelial neoplasia.
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AKT1, AKT2 and AKT3-Dependent Cell Survival is Cell Line-Specific and Knockdown of All Three Isoforms Selectively Induces Apoptosis in 20 Human Tumor Cell Lines.
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Akt2 and p-Akt overexpression in oral cancer cells is due to a reduced rate of protein degradation.
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Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.
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AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells.
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AKTivation mechanisms.
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Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth.
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Aldehyde oxidase 1 promoted the occurrence and development of colorectal cancer by up-regulation of expression of CD133.
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Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma.
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Alleviating the suppression of glycogen synthase kinase-3beta by Akt leads to the phosphorylation of cAMP-response element-binding protein and its transactivation in intact cell nuclei.
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Allogeneic Stem Cell Transplantation after Fanconi Anemia Conditioning in Children with Ataxia-Telangiectasia Results in Stable T Cell Engraftment and Lack of Infections despite Mixed Chimerism.
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Allopurinol Protects against Ischemia/Reperfusion-Induced Injury in Rat Urinary Bladders.
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Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin.
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alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression.
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Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model.
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alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor kappa B signaling pathways.
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Alpha1-antitrypsin, old dog, new tricks. Alpha1-antitrypsin exerts in vitro anti-inflammatory activity in human monocytes by elevating cAMP.
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Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis.
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Alteration of PDGFR?-Akt-mTOR Pathway Signaling in Fibrosarcomatous Transformation of Dermatofibrosarcoma Protuberans.
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Alteration of the ATM gene occurs in gastric cancer cell lines and primary tumors associated with cellular response to DNA damage.
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Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer.
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Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin.
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Alterations in Promoter Methylation Status of Tumor Suppressor HIC1, SFRP2, and DAPK1 Genes in Prostate Carcinomas.
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Alterations in the cyclic AMP signal transduction pathway regulating ribonucleotide reductase gene expression in malignant H-ras transformed cell lines.
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Alterations in the level of phosphotyrosine signal transduction constituents in human parotid tumors.
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Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
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Alterations of microRNAs are associated with impaired growth of MCF-7 breast cancer cells induced by inhibition of casein kinase 2.
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Alterations of protein kinase isozymes in transplantable human lung cancer with special reference to the phosphorylation of arylsulfatase B.
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Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer.
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Altered expression of Akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue.
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Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
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Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase.
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Alternative splicing of the porcine glycogen synthase kinase 3? (GSK-3?) gene with differential expression patterns and regulatory functions.
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AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.
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American Chemical Society - 240th national meeting - chemistry for preventing and combating disease: part 2.
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Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation.
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Aminoglutethimide, a steroidogenesis inhibitor, abolishes hormonal induction of ornithine decarboxylase in steroidogenic tissues: evidence for its role as cAMP-dependent protein kinase inhibitor.
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AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway.
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AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.
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AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
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AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastoma.
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AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.
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AMPKalpha2 Regulates Bladder Cancer Growth Through SKP2-mediated Degradation of p27.
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Amplification by (-)-epigallocatechin gallate and chlorogenic acid of TNF-?-stimulated interleukin-6 synthesis in osteoblasts.
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An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B.
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An AKT/PRMT5/SREBP1 axis in lung adenocarcinoma regulates de novo lipogenesis and tumor growth.
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An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.
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An Anti-Cancer Drug Candidate OSI-027 and its Analog as Inhibitors of mTOR: Computational Insights Into the Inhibitory Mechanisms.
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An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway.
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An automated image capture and quantitation approach to identify proteins affecting tumor cell proliferation.
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An EGFR and AKT Signaling Pathway was Identified with Mediation Model in Osteosarcomas Clinical Study.
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An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
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An engineered site for protein kinase C flanking the SV40 large T-antigen NLS confers phorbol ester-inducible nuclear import.
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An exploration of genotype-phenotype link between Peutz-Jeghers syndrome and STK11: a review.
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An Exploratory Study of Radiation Dermatitis in Breast Cancer Patients.
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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.
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An IFN-?-stimulated ATF6-C/EBP-?-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy.
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An immortalized human cell line bearing a PRKAR1A-inactivating mutation: effects of overexpression of the wild-type Allele and other protein kinase A subunits.
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An intact zinc ring finger is required for tumor necrosis factor receptor-associated factor-mediated nuclear factor-kappaB activation but is dispensable for c-Jun N-terminal kinase signaling.
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An Iron Shield to Protect Epigallocatehin-3-Gallate from Degradation: Multifunctional Self-Assembled Iron Oxide Nanocarrier Enhances Protein Kinase CK2 Intracellular Targeting and Inhibition.
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Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability.
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Analysis of Aurora kinase A expression in CD34(+) blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia.
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Analysis of Cell-type Specific Expression of CK1{varepsilon} in Various Tissues of Young Adult BALB/c Mice and in Mammary Tumors of SV40 T-Ag Transgenic Mice.
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Analysis of complex protein kinase B signalling pathways in human prostate cancer samples.
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Analysis of Fifty Hotspot Mutations of Lung Squamous Cell Carcinoma in Never-smokers.
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Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway.
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Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
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Analysis of MiR-195 and MiR-497 Expression, Regulation and Role in Breast Cancer.
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Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology.
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Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma.
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Analysis of PI3K/AKT/mTOR signalling pathway in high risk neuroblastic tumours.
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Analysis of possible mechanisms accounting for raf-1 kinase inhibitor protein downregulation in hepatocellular carcinoma.
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Analysis of promoter hypermethylation of death-associated protein kinase and p16 tumor suppressor genes in actinic keratoses and squamous cell carcinomas of the skin.
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Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.
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Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells.
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Anaplastic thyroid carcinoma: expression profile of targets for therapy offers new insights for disease treatment.
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Androgen receptor in laryngeal carcinoma: could there be an androgen-refractory tumor?
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Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2.
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Androgen-Secreting Ovarian Tumors.
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Angiotensin II affects inflammation mechanisms via AMPK-related signalling pathways in HL-1 atrial myocytes.
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Angustoline Inhibited Esophageal Tumors Through Regulating LKB1/AMPK/ELAVL1/LPACT2 Pathway and Phospholipid Remodeling.
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ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome.
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Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs.
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Antagonist of thromboxane A2 receptor by SQ29548 lowers DOCA-induced hypertension in diabetic rats.
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Antagonistic control of tumor necrosis factor receptors by protein kinases A and C. Enhancement of TNF receptor synthesis by protein kinase A and transmodulation of receptors by protein kinase C.
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Anti- and pro-tumor functions of autophagy.
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Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in A?1-42-Induced Mice.
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Anti-androgen receptor activity of apoptotic CK2 inhibitor CX4945 in human prostate cancer LNCap cells.
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Anti-breast-Cancer Activity Exerted by ?-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
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Anti-cancer effects of Tranilast: An update.
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Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-? and c-Jun N-terminal kinase pathway.
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Anti-Inflammatory and Anti-Apoptotic Effects of Acer Palmatum Thumb. Extract, KIOM-2015EW, in a Hyperosmolar-Stress-Induced In Vitro Dry Eye Model.
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Anti-inflammatory and immune response regulation of Si-Ni-San in 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin dysfunction.
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Anti-Inflammatory and Reactive Oxygen Species Suppression through Aspirin Pretreatment to Treat Hyperoxia-Induced Acute Lung Injury in NF-?B-Luciferase Inducible Transgenic Mice.
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Anti-inflammatory Effects of Oxymatrine Through Inhibition of Nuclear Factor-kappa B and Mitogen-activated Protein Kinase Activation in Lipopolysaccharide-induced BV2 Microglia Cells.
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Anti-inflammatory Metabolites from Chaetomium nigricolor.
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Anti-inflammatory Potential of GSK-3 Inhibitors.
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Anti-inflammatory spiroditerpenoids from Penicillium bialowiezense.
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Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells.
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Anti-obesity effects of 3-hydroxychromone derivative, a novel small-molecule inhibitor of glycogen synthase kinase-3.
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Anti-progranulin/GP88 antibody AG01 inhibits triple negative breast cancer cell proliferation and migration.
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Anti-proliferative effects of 8-chloro-cAMP and other cAMP analogs are unrelated to their effects on protein kinase A regulatory subunit expression.
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Anti-tumor activity of high-dose EGFR tyrosine kinase inhibitor and sequential docetaxel in wild type EGFR non-small cell lung cancer cell nude mouse xenografts.
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Anti-tumor efficacy of BEZ235 is complemented by its anti-angiogenic effects via downregulation of PI3K-mTOR-HIF1alpha signaling in HER2-defined breast cancers.
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Antiangiogenic effects of AG36, a triterpenoid saponin from Ardisia gigantifolia stapf.
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Antiangiogenics meet nanotechnology.
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Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts.
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Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase.
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Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis.
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Anticancer activity of the Aurora A kinase inhibitor MK-5108 in non-small-cell lung cancer (NSCLC) in vitro as monotherapy and in combination with chemotherapies.
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Anticancer agents based on vulnerable components in a signalling pathway.
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Anticancer alkaloid lamellarins inhibit protein kinases.
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Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types (Review).
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Anticancer potential of curcumin: preclinical and clinical studies.
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Anticancer potential of emodin.
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Anticarcinogenic effect of retinoids on 7,12-dimethylbenz(a)anthracene-induced mammary tumor induction, and its relationship to cyclic AMP-dependent protein kinase.
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Antihyperlipidemic effect of selected pyrimidine derivatives mediated through multiple pathways.
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Antihypertensive potential of selected pyrimidine derivatives: Explanation of underlying mechanistic pathways.
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Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis.
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Antiproliferation and apoptosis on RKO colon cancer by Millingtonia hortensis.
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Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma.
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Antiproliferative effect of the methanol extract from the roots of Petasites japonicus on Hep3B hepatocellular carcinoma cells in vitro and in vivo.
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Antisense oligonucleotide therapy in urology.
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Antisense oligonucleotides against protein kinase CK2-alpha inhibit growth of squamous cell carcinoma of the head and neck in vitro.
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Antisense oligonucleotides: target validation and development of systemically delivered therapeutic nanoparticles.
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Antisense protein kinase A RI alpha-induced tumor reversion: portrait of a microarray.
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Antisense protein kinase A RIalpha acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy.
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Antisense raf oligodeoxyribonucleotide is a radiosensitizer in vivo.
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Antisense raf oligodeoxyribonucleotide is protected by liposomal encapsulation and inhibits Raf-1 protein expression in vitro and in vivo: implication for gene therapy of radioresistant cancer.
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Antisense targeting protein kinase A type I as a drug for integrated strategies of cancer therapy.
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Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells.
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Antitumor Activity In Vivo and Vitro of New Chiral Derivatives of Baicalin and Induced Apoptosis via the PI3K/Akt Signaling Pathway.
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Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells.
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Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A.
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Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide.
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Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases.
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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase.
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Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition.
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Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.
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Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases.
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Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.
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Antitumor effect of a novel proapoptotic peptide that impairs the phosphorylation by the protein kinase 2 (casein kinase 2).
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Antitumor effect of a selective COX-2 inhibitor, celecoxib, may be attributed to angiogenesis inhibition through modulating the PTEN/PI3K/Akt/HIF-1 pathway in an H22 murine hepatocarcinoma model.
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Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer.
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Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial-mesenchymal transition via regulating the PI3K/AKT/mTOR pathway.
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Antitumor Effects and the Compatibility Mechanisms of Herb Pair Scleromitrion diffusum (Willd.) R. J. Wang-Sculellaria barbata D. Don.
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Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.
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Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.
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Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor.
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Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3 ? and APC and Inhibiting Gene ? -Catenin.
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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.
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Antitumoral activity of allosteric inhibitors of protein kinase CK2.
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Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection.
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Antiviral effects of cyclosporine A in neonatal mice with rotavirus-induced diarrhea.
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Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion.
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ANXA1-GSK3? interaction and its involvement in NSCLC metastasis.
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Anxiolytic Effects of 8-O-Acetyl Shanzhiside Methylester on Acute and Chronic Anxiety via Inflammatory Response Inhibition and Excitatory/Inhibitory Transmission Imbalance.
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APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.
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Apicidin-resistant HA22T hepatocellular carcinoma cells massively promote pro-survival capability via IGF-IR/PI3K/Akt signaling pathway activation.
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Apigenin Attenuates Insulin-Like Growth Factor-I Signaling in an Autochthonous Mouse Prostate Cancer Model.
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Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2?.
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Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3?derived sphere-forming cells.
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Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses.
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Apoptosis of cancer cells is triggered by selective crosslinking and inhibition of receptor tyrosine kinases.
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Appendix carcinoid associated with the Peutz-Jeghers syndrome.
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Application Of Kinase Inhibitors For Anti-Aging Intervention.
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Applications of pathology-assisted image analysis of immunohistochemistry-based biomarkers in oncology.
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Aquaporin 9 is down-regulated in hepatocellular carcinoma and its over-expression suppresses hepatoma cell invasion through inhibiting epithelial-to-mesenchymal transition.
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AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors.
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Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells.
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ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis.
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Arg-GlcNAcylation on TRADD by NleB and SseK1 Is Crucial for Bacterial Pathogenesis.
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ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.
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Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
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AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel.
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Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation.
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Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity.
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ASK1 is essential for JNK/SAPK activation by TRAF2.
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Assessment of Aurora A kinase expression in breast cancer: a tool for early diagnosis?
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Assessment of CK2 constitutive activity in cancer cells.
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Assessment of DNA-PKcs kinase activity by quantum dot-based microarray.
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Assessment of erlotinib pharmacodynamics in tumors and skin of patients with head and neck cancer.
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Association between ATM polymorphisms and cancer risk: a meta-analysis.
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Association between ATM rs1801516 polymorphism and cancer susceptibility: a meta-analysis involving 12,879 cases and 18,054 controls.
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Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population.
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Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer.
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Association between common genetic variants in pre-microRNAs and the clinicopathological characteristics and survival of gastric cancer patients.
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Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility.
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Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer.
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Association between raf kinase inhibitor protein loss and prognosis in cancers of the digestive system: a meta-analysis.
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Association between RNF2+P-AKT expression in pretreatment biopsy specimens, and poor survival following radiotherapy in patients with esophageal squamous cell carcinoma.
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Association between the expression levels of TAZ, AXL and CTGF and clinicopathological parameters in patients with colon cancer.
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Association between the STK15 F31I polymorphism and cancer susceptibility: a meta-analysis involving 43,626 subjects.
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Association of Aspirin and Nonsteroidal Anti-Inflammatory Drugs With Colorectal Cancer Risk by Molecular Subtypes.
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Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients.
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Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.
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Association of body mass index with ER, PR and 14-3-3? expression in tumor and stroma of type I and type II endometrial carcinoma.
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Association of cellular localization of glycogen synthase kinase 3beta in the digestive tract with cancer development.
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Association of chromosome 19 to lung cancer genotypes and phenotypes.
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Association of EGFR and KRAS mutations with expression of p-AKT, DR5 and DcR1 in non-small cell lung cancer.
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Association of increased phosphatidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas.
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Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.
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Association of PALB2 Messenger RNA Expression with Platinum-Docetaxel Efficacy in Advanced Non-Small Cell Lung Cancer.
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Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy.
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Association of polyomavirus middle tumor antigen with 14-3-3 proteins.
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Association of Protein Expression and Methylation of DAPK1 with Clinicopathological Features in Invasive Ductal Carcinoma Patients from Kashmir
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Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non-Small Cell Lung Cancer.
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Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients.
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Asymmetric expression of protein kinase CK2 subunits in human kidney tumors.
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AT7867 Is a Potent and Oral Inhibitor of AKT and p70 S6 Kinase That Induces Pharmacodynamic Changes and Inhibits Human Tumor Xenograft Growth.
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Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy.
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Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
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Ataxia-Telangiectasia Mutated (ATM) Protein Signaling Participates in Development of Pulmonary Arterial Hypertension in Rats.
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Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
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Ataxia-telangiectasia mutated interactor regulates head and neck cancer metastasis via KRas expression.
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Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra.
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Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer.
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Atg14 protects the intestinal epithelium from TNF-triggered villus atrophy.
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Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction.
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Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.
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ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells.
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ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.
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ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
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ATM Expression Is Elevated in Established Radiation-Resistant Breast Cancer Cells and Improves DNA Repair Efficiency.
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Atm heterozygosity cooperates with loss of Brca1 to increase the severity of mammary gland cancer and reduce ductal branching.
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ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy.
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ATM Mutations in Cancer: Therapeutic Implications.
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ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming.
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ATM polymorphisms and risk of lung cancer among never smokers.
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ATM protein overexpression in prostate tumors: possible role in telomere maintenance.
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ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion.
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ATM rs189037 (G?>?A) polymorphism increased the risk of cancer: an updated meta-analysis.
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ATM rs189037 (G > A) polymorphism and risk of lung cancer and head and neck cancer: A meta-analysis.
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ATM rs189037 significantly increases the risk of cancer in non-smokers rather than smokers: an updated meta-analysis.
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ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
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ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition???deletion.
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ATM, radiation, and the risk of second primary breast cancer.
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ATM-Deficient Cancers Provide New Opportunities for Precision Oncology.
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ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion.
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Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia.
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ATP-competitive inhibitors of mTOR: an update.
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ATR Is a Therapeutic Target in Synovial Sarcoma.
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ATR/CHK1 inhibitors and cancer therapy.
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Attenuated Salmonella engineered with an apoptosis-inducing factor (AIF) eukaryotic expressing system enhances its anti-tumor effect in melanoma in vitro and in vivo.
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Attenuation of ERK/RSK2-Driven NF?B Gene Expression and Cancer Cell Proliferation by Kurarinone, a Lavandulyl Flavanone Isolated from Sophora flavescens Ait. Roots.
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Atypical Protein Kinase C? Is Required for Wnt3a-dependent Neurite Outgrowth and Binds to Phosphorylated Dishevelled 2.
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AURKA contributes to the progression of oral squamous cell carcinoma (OSCC) through modulating epithelial-to-mesenchymal transition (EMT) and apoptosis via the regulation of ROS.
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Aurora A and B kinases as targets for cancer: will they be selective for tumors?
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Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia.
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Aurora A controls CD8+ T cell cytotoxic activity and antiviral response.
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Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor.
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Aurora A inhibition disrupts chromosome condensation and spindle assembly during the first embryonic division in pigs.
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Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer.
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Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes.
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Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial Design.
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Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma.
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Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers.
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Aurora A is a repressed effector target of the chromatin remodeling protein INI1/hSNF5 required for rhabdoid tumor cell survival.
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Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer.
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Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers.
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Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.
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Aurora A is essential for early embryonic development and tumor suppression.
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Aurora A kinase (AURKA) in normal and pathological cell division.
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Aurora A kinase activity is required to maintain the spindle assembly checkpoint active during pro-metaphase.
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Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells.
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Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.
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Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.
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Aurora A Kinase Is a Priority Pharmaceutical Target for the Treatment of Cancers.
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Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53.
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Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis.
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Aurora A overexpression in breast cancer patients induces taxane resistance and results in worse prognosis.
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Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
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Aurora A selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells and shows potent preclinical antitumor efficacy.
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Aurora B expression in metastatic effusions from advanced-stage ovarian serous carcinoma is predictive of intrinsic chemotherapy resistance.
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Aurora B induces epithelial-mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis.
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Aurora B kinase inhibition in mitosis: Strategies for optimising the use of aurora kinase inhibitors such as AT9283.
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Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer.
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Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor.
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Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors.
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Aurora kinase A inhibitors: promising agents in antitumoral therapy.
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Aurora kinase A localises to mitochondria to control organelle dynamics and energy production.
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Aurora kinase a messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma.
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Aurora kinase B is an independent protective factor in superficial bladder tumours with a dysfunctional G1 checkpoint.
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Aurora kinase inhibitor restrains STAT5-activated leukemic cell proliferation by inducing mitochondrial impairment.
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Aurora kinase inhibitors as anti-cancer therapy.
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Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias.
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Aurora kinases as anticancer drug targets.
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Aurora kinases as prognostic biomarkers in ovarian carcinoma.
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Aurora kinases link chromosome segregation and cell division to cancer susceptibility.
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AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.
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Aurora-a contributes to radioresistance by increasing NF-kappaB DNA binding.
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Aurora-A enhances malignant development of esophageal squamous cell carcinoma (ESCC) by phosphorylating ?-catenin.
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Aurora-A gene is frequently amplified in basal-like breast cancer.
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Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells.
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Aurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe.
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Aurora-A kinase-inactive mutants disrupt the interaction with Ajuba and cause defects in mitotic spindle formation and G2/M phase arrest in HeLa cells.
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Aurora-A Overexpression in Mouse Liver Causes p53-Dependent Premitotic Arrest during Liver Regeneration.
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Aurora-A regulates autophagy through the Akt pathway in human prostate cancer.
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Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells.
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Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkin's lymphoma.
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Autoantibody cancer biomarker: extracellular protein kinase a.
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Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells.
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Autophagosome-mediated EGFR down-regulation induced by the CK2 inhibitor enhances the efficacy of EGFR-TKI on EGFR-mutant lung cancer cells with resistance by T790M.
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Autophagy as a cell death and tumor suppressor mechanism.
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Autophagy drives fibroblast senescence through MTORC2 regulation.
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Autophagy in the physiological endometrium and cancer.
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Autophagy Induced by CX-4945, a Casein Kinase 2 Inhibitor, Enhances Apoptosis in Pancreatic Cancer Cell Lines.
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Autophagy Regulatory Genes MET and RIPK2 Play a Prognostic Role in Pancreatic Ductal Adenocarcinoma: A Bioinformatic Analysis Based on GEO and TCGA.
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Awakening the Hippo co-activator YAP1, a mercurial cancer gene, in hematologic cancers.
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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.
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Backbone Cyclic Peptide Inhibitors of Protein Kinase B (PKB/Akt).
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Bacterial proteins as potential drugs in the treatment of leukemia.
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BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2+-CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells.
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BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses.
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BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
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Baicalin attenuates myocardial ischemia-reperfusion injury through Akt/NF-?B pathway.
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Baicalin suppresses lung cancer growth by targeting PDZ-binding kinase/T-LAK cell-originated protein kinase.
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Balance between NF-kappaB and JNK/AP-1 activity controls dendritic cell life and death.
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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.
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BAY-43-9006 Bayer/Onyx.
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Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy.
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Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase.
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Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells.
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BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition.
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BCL6 confers KRAS-mutant non-small-cell lung cancer resistance to BET inhibitors.
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Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II.
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Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways.
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BEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma--A Trial of the ECOG-ACRIN Cancer Research Group (E2804).
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Beta(3)-mediated engulfment of apoptotic tumor cells by dendritic cells is dependent on CAMKII: inhibition by HIV-1 Tat.
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beta-adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the IkappaB/NF-kappaB pathway.
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beta-Catenin and NF-kappaB cooperate to regulate the uPA/uPAR system in cancer cells.
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beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.
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Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis.
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Beta-catenin mutations in craniopharyngiomas and pituitary adenomas.
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beta-Catenin signaling: therapeutic strategies in oncology.
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Beyond DNA Repair: DNA-PKcs in Tumor Metastasis, Metabolism and Immunity.
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Beyond Kinases: Targeting Replication Stress Proteins in Cancer Therapy.
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BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.
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Biliary intraductal tubule-forming neoplasm: A whole exome sequencing study of MUC5AC-positive and -negative cases.
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BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by ?TrCP1.
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Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1.
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Binding of p110 retinoblastoma protein inhibits nuclear import of simian virus SV40 large tumour antigen.
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Binding studies and biological evaluation of ?-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV.
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Bioactive compounds in plant materials for the prevention of diabetesand obesity.
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Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function.
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Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.
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Biodistribution and metabolism of a mixed backbone oligonucleotide (GEM 231) following single and multiple dose administration in mice.
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Bioinformatics Exploration of PAK1 (P21-activated kinase-1) Revealed Potential Network Gene Elements in Breast Invasive Carcinoma.
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Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer.
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Biological activity of mannosylerythritol lipids on the mammalian cells.
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Biological and clinical significance of GSK-3beta in mantle cell lymphoma--an immunohistochemical study.
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Biological Characterization of TAK-901, an Investigational, Novel, Multitargeted Aurora B Kinase Inhibitor.
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Biology of Aurora A kinase: Implications in cancer manifestation and therapy.
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Biomarkers of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Beyond PD-L1.
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Biomarkers predicting the response to chemotherapy and the prognosis in patients with esophageal squamous cell carcinoma.
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Biophysical studies and modelling indicate the binding preference of TAZ WW domain for LATS1 PPxY motif.
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Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction.
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Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.
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Biphasic reduction of histone H3 phosphorylation in response to N-nitroso compounds induced DNA damage.
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Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer.
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Bizarre parosteal osteochondromatous proliferation in the lingual area of the mandibular body versus osteochondroma at the mandibular condyle.
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Blockage of PAK1 alleviates the proliferation and invasion of NSCLC cells via inhibiting ERK and AKT signaling activity.
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Blockage of progesterone receptor effectively protects pancreatic islet beta cell viability.
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Blocking Aerobic Glycolysis by Targeting Pyruvate Dehydrogenase Kinase in Combination with EGFR TKI and Ionizing Radiation Increases Therapeutic Effect in Non-Small Cell Lung Cancer Cells.
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Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control.
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BMI-1 suppression increases the radiosensitivity of oesophageal carcinoma via the PI3K/Akt signaling pathway.
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Body fatness and mTOR pathway activation of breast cancer in the Women's Circle of Health Study.
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Bone Abnormalities in Mice with Protein Kinase A (PKA) Defects Reveal a Role of Cyclic AMP Signaling in Bone Stromal Cell-Dependent Tumor Development.
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Bortezomib congeners induce apoptosis of hepatocellular carcinoma via CIP2A inhibition.
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Both Internalization and AIP1 Association Are Required for Tumor Necrosis Factor Receptor 2-Mediated JNK Signaling.
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BRAF and AXL oncogenes drive RIPK3 expression loss in cancer.
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BRAF and endocrine tumors: mutations are frequent in papillary thyroid carcinomas, rare in endocrine tumors of the gastrointestinal tract and not detected in other endocrine tumors.
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BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets.
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BRAF as a Target for Cancer Therapy.
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BRAF gene: From human cancers to developmental syndromes.
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BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives.
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BRAF Mutation in Papillary Thyroid Cancer and Its Value in Tailoring Initial Treatment: A Systematic Review and Meta-Analysis.
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BRAF mutation testing in clinical practice.
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BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma.
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BRAFV600E-induced KRT19 expression in thyroid cancer promotes lymph node metastasis via EMT.
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BRAFV600E: Implications for Carcinogenesis and Molecular Therapy.
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Brain and induced pluripotent stem cell-derived neural stem cells as an in vitro model of neurodegeneration in ataxia-telangiectasia.
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Brassinin Induces Apoptosis in PC-3 Human Prostate Cancer Cells through the Suppression of PI3K/Akt/mTOR/S6K1 Signaling Cascades.
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BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis.
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BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility - A proteomics study.
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BRCA1 degradation in response to mitochondrial damage in breast cancer cells.
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BRCA1 in cancer, cell cycle and genomic stability.
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Breaking the DNA damage response via serine/threonine kinase inhibitors to improve cancer treatment.
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Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4.
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Breaking up is hard to do: RalA, mitochondrial fission and cancer.
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Breast cancer cells respond differently to docetaxel depending on their phenotype and on survivin upregulation.
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Breast cancer metastasis driven by ErbB2 and 14-3-3xi: A division of labor.
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Breast Carcinoma-associated Fibroblasts Share Similar Biomarker Profiles in Matched Lymph Node Metastasis.
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BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancer.
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Brief Report: Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients.
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Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models.
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Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome.
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Bryostatin 1 modulates beta-catenin subcellular localization and transcription activity through protein kinase D1 activation.
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BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1.
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BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition.
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BUB1 promotes proliferation of liver cancer cells by activating SMAD2 phosphorylation.
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BUB1B promotes hepatocellular carcinoma progression via activation of the mTORC1 signaling pathway.
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Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways.
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Buparlisib in breast cancer.
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c-erbB-2 oncoprotein expression related to chemoradioresistance in esophageal squamous cell carcinoma.
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c-FLIP(L) enhances anti-apoptotic Akt functions by modulation of Gsk3beta activity.
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c-JUN N-terminal kinase (JNK) is activated and contributes to tumor cell proliferation in classical Hodgkin lymphoma.
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c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway.
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c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer.
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c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists.
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c-Jun N-terminal kinase activation during warm hepatic ischemia/reperfusion injuries in a rat model.
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c-Jun N-terminal kinase and Akt signalling pathways regulating tumour necrosis factor-?-induced interleukin-32 expression in human lung fibroblasts: implications in airway inflammation.
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c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells.
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c-Jun N-terminal kinase in pancreatic tumor stroma augments tumor development in mice.
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c-Jun N-terminal kinase inhibitor SP600125 enhances barrier function and elongation of human pancreatic cancer cell line HPAC in a Ca-switch model.
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c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells.
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C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
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c-Jun N-terminal kinase negatively regulates dsRNA and RSV induction of tumor necrosis factor- alpha transcription in human epithelial cells.
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c-Jun N-Terminal Kinase Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells.
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c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun.
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c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition.
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c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines.
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C-Raf controlled pathways in the protection of tumor cells from apoptosis.
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C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
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Cables1 complex couples survival signaling to the cell death machinery.
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Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines.
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Calcium/calmodulin?dependent protein kinase II enhances metastasis of human gastric cancer by upregulating nuclear factor??B and Akt?mediated matrix metalloproteinase?9 production.
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Calpastatin phosphorylation regulates radiation-induced calpain activity in glioblastoma.
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CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1? in Hepatoma Cells.
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CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.
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cAMP and protein kinase A in endocrine (and other) tumors.
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cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
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cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.
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Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?
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Cancer associated fibroblast FAK regulates malignant cell metabolism.
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Cancer epigenomics: implications of DNA methylation in personalized cancer therapy.
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Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors.
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Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls.
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Cancer risk from low dose radiation in Ptch1+/- mice with inactive DNA repair systems: Therapeutic implications for medulloblastoma.
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Cancer-associated fibroblasts promote PD-L1 expression in mice cancer cells via secreting CXCL5.
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Cancer-type dependent expression of CK2 transcripts.
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Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome.
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Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes.
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Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
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Cannabinoid receptors in conjunctival epithelium: identification and functional properties.
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Carbachol alleviates myocardial injury in septic rats through PI3K/AKT signaling pathway.
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CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways.
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Cardamonin inhibits the proliferation and metastasis of non-small-cell lung cancer cells by suppressing the PI3K/Akt/mTOR pathway.
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Cardiac glycoside bufalin blocks cancer cell growth by inhibition of Aurora A and Aurora B activation via PI3K-Akt pathway.
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Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog.
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Carney complex and McCune Albright syndrome: An overview of clinical manifestations and human molecular genetics.
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Carney complex, Peutz-Jeghers syndrome, Cowden disease, and Bannayan-Zonana syndrome share cutaneous and endocrine manifestations, but not genetic loci.
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Carney Complex.
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Carney complex: pathology and molecular genetics.
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Case-control, kin-cohort and meta-analyses provide no support for STK15 F31I as a low penetrance colorectal cancer allele.
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Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells.
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Casein kinase 1 epsilon expression predicts poorer prognosis in low T-stage oral cancer patients.
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Casein Kinase 1? as a Regulator of Wnt-Driven Cancer.
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Casein kinase 1? inhibits p53 downstream of MDM2?mediated autophagy and apoptosis in acute myeloid leukemia.
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Casein kinase 1? promotes cell proliferation by regulating mRNA translation.
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Casein kinase 1?-dependent feedback loop controls autophagy in RAS-driven cancers.
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Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
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Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog-GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition.
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Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription.
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Casein kinase 2 controls the survival of normal thymic and leukemic ?? T cells via promotion of AKT signaling.
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Casein kinase 2 inhibition modulates the DNA damage response but fails to radiosensitize malignant glioma cells.
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Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide.
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Casein kinase 2 interacting protein 1 positively regulates caudal-related homeobox 1 in intestinal-type gastric cancer.
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Casein kinase 2 regulates both apoptosis and the cell cycle following DNA damage induced by 6-thioguanine.
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Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.
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Casein Kinase 2: a novel player in glioblastoma therapy and cancer stem cells.
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Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex.
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Casein Kinase II (CK2) as a Therapeutic Target for Hematological Malignancies.
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Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines.
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Casein kinase II accumulation in the nucleolus and its role in nucleolar phosphorylation.
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Casein kinase II and the tumor suppressor protein P53 associate in a molecular complex that is negatively regulated upon P53 phosphorylation.
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Casein kinase II inhibition induces apoptosis in pancreatic cancer cells.
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Casein kinase II is elevated in solid human tumours and rapidly proliferating non-neoplastic tissue.
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Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.
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Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis.
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Caspase-3 knockout attenuates radiation-induced tumor repopulation via impairing the ATM/p53/Cox-2/PGE2 pathway in non-small cell lung cancer.
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Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6.
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Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.
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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.
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CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells.
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CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity.
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Cdc7 as a potential new target for cancer therapy.
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CDDO-Me inhibits tumor growth and prevents recurrence of pancreatic ductal adenocarcinoma.
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Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity.
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CDK5 is essential for TGF-?1-induced epithelial-mesenchymal transition and breast cancer progression.
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CDK5RAP3 suppresses Wnt/?-catenin signaling by inhibiting AKT phosphorylation in gastric cancer.
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cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion.
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cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain.
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Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways.
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Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours.
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Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
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Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways.
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Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.
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Cell Intrinsic Role of Cox-2 in Pancreatic Cancer Development.
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Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer.
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Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
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Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation.
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Cellular functions of 14-3-3 zeta in apoptosis and cell adhesion emphasize its oncogenic character.
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Cellular signal transduction and the reversal of malignancy.
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Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.
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Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.
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Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study.
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Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival.
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Cerebral Abnormalities in Adults with Ataxia-Telangiectasia.
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Cerebrospinal fluid biomarkers in Guillain-Barré syndrome--where do we stand?
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Cervical malignant mixed mesonephric tumour: A case report with local recurrence after six-years and next-generation sequencing analysis with particular reference to the ataxia telangiectasia mutated gene.
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CH-01 is a Hypoxia-Activated Prodrug That Sensitizes Cells to Hypoxia/Reoxygenation Through Inhibition of Chk1 and Aurora A.
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Challenges in implementing model-based phase I designs in a grant-funded clinical trials unit.
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Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study.
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Changes in messenger RNA expression of protein kinase A regulatory subunit ialpha in breast cancer patients treated with tamoxifen.
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Characterisation of integrin-linked kinase signalling in sporadic human colon cancer.
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Characterization and hormonal regulation of casein kinase II activity in heterotransplanted human breast tumors in nude mice.
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Characterization of 14-3-3sigma dimerization determinants: requirement of homodimerization for inhibition of cell proliferation.
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Characterization of an histone kinase activity specifically found in hyperfunctioning benign thyroid tumors.
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Characterization of Aurora A and Its Impact on the Effect of Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer.
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Characterization of highly phosphorylated subcomponents of rat thymus H1 histone.
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Characterization of human CD4 helper T cell responses against Aurora kinase A.
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Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity.
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Characterization of membrane-shed micro-vesicles from cytokine-stimulated beta-cells using proteomics strategies.
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Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors.
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Characterization of parathyroid hormone/parathyroid hormone-related protein receptor and signaling in hypercalcemic Walker 256 tumor cells.
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Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.
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Characterization of protein tyrosine kinase activity in murine Leydig tumor cells.
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Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.
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Characterization of soy-based changes in Wnt-frizzled signaling in prostate cancer.
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Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.
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Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis.
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Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2?': implications for pathological roles of CK2 in promoting cancer cell survival.
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Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms.
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Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil.
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Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients.
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Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells.
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CHEK2 1100delC, IVS2+1G>A and I157T mutations are not present in colorectal cancer cases from Turkish population.
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Chemically induced degradation of CK2 by proteolysis targeting chimeras based on a ubiquitin-proteasome pathway.
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Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02.
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Chemokine contribution to neuropathic pain: Respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons.
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Chemoproteomics Reveals the Antiproliferative Potential of Parkinson's Disease Kinase Inhibitor LRRK2-IN-1 by Targeting PCNA Protein.
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Chfr is required for tumor suppression and Aurora A regulation.
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Chimeric mouse models for lung adenocarcinomas.
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Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest.
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Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells.
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Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells.
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CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells.
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Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing.
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Chk1 suppression leads to a reduction in the enhanced radiation-induced invasive capability on breast cancer cells.
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Chk2 activation and phosphorylation-dependent oligomerization.
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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
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Cholesterol sensitivity of endogenous and myristoylated Akt.
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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas.
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Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer.
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Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity.
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Chronic exposure of Interleukin-13 Suppress the Induction of Matrix Metalloproteinase-1 by Tumor Necrosis Factor ? in Normal and Scleroderma Dermal Fibroblasts through Protein Kinase B/Akt.
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Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation.
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Chronic type-I diabetes could not impede the anti-inflammatory and anti-apoptotic effects of combined postconditioning with ischemia and cyclosporine A in myocardial reperfusion injury.
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cIAP2 Upregulated by E6 Oncoprotein via Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/AKT Pathway Confers Resistance to Cisplatin in Human Papillomavirus 16/18-Infected Lung Cancer.
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cIAPs and XIAP regulate myelopoiesis through cytokine production in a RIPK1 and RIPK3 dependent manner.
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Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK.
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CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo.
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CIGB-300, an anti-CK2 peptide, inhibits angiogenesis, tumor cell invasion and metastasis in lung cancer models.
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CIGB-300: A peptide-based drug that impairs the Protein Kinase CK2-mediated phosphorylation.
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Cilostazol enhances casein kinase 2 phosphorylation and suppresses tumor necrosis factor-alpha-induced increased phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells.
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Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model.
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Cilostazol protects against acetic acid-induced colitis in rats: Possible role for cAMP/SIRT1 pathway.
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Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis.
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CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells.
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Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3?.
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circPHIP promotes oral squamous cell carcinoma progression by sponging miR-142-5p and regulating PHIP and ACTN4 expression.
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Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis.
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cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression.
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Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1.
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CK1? kinase activity is modulated by Chk1-mediated phosphorylation.
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CK1epsilon is required for breast cancers dependent on beta-catenin activity.
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CK2 Inhibitor CX-4945 Blocks TGF-?1-Induced Epithelial-to-Mesenchymal Transition in A549 Human Lung Adenocarcinoma Cells.
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CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor.
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CK2 Molecular Targeting-Tumor Cell-Specific Delivery of RNAi in Various Models of Cancer.
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CK2-An Emerging Target for Neurological and Psychiatric Disorders.
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CK2: A key player in cancer biology.
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CK2? is essential for embryonic morphogenesis.
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CKIP-1 suppresses odontoblastic differentiation of dental pulp stem cells via BMP2 pathway and can interact with NRP1.
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CLDN6-induced apoptosis via regulating ASK1-p38/JNK signaling in breast cancer MCF-7 cells.
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Clearing the TRAIL for Cancer Therapy.
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Clinical and biological significance of PIM1 kinase in osteosarcoma.
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Clinical and prognostic significance of Raf kinase inhibitory protein expression in gastrointestinal stromal tumors.
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Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma.
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Clinical experience with aurora kinase inhibitors: a review.
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Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas.
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Clinical Impact of Tumor DNA Repair Expression and T-cell Infiltration in Breast Cancers.
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Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer.
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Clinical manifestations and STK11 germline mutations in Taiwanese patients with Peutz-Jeghers syndrome.
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Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing.
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Clinical significance of 14-3-3 zeta in human esophageal cancer.
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Clinical significance of midkine expression in sporadic desmoid tumors.
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Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
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Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM 231) targeted against protein kinase A type I.
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Clinical studies of antisense therapy in cancer.
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Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas.
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Clinically relevant GSK?3? inhibitor 9?ING?41 is active as a single agent and in combination with other antitumor therapies in human renal cancer.
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Clinically significant association between the maximum standardized uptake value on 18F-FDG PET and expression of phosphorylated Akt and S6 kinase for prediction of the biological characteristics of renal cell cancer.
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Clinicians' attitudes toward general screening of the Ashkenazi-Jewish population for prevalent founder BRCA1/2 and LRRK2 mutations.
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Clinicopathological and biological significance of aberrant activation of glycogen synthase kinase-3 in ovarian cancer.
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Clinicopathological features and prognostic implications of Raf kinase inhibitor protein downregulation in tongue squamous cell carcinoma.
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Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.
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Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer.
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Clinicopathological significance of ribosomal protein S6 kinase A6 in lung squamous cell carcinoma: an immunohistochemical and RNA-seq study.
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Clinicopathological significance of ROCK1 and PIK3CA expression in nasopharyngeal carcinoma.
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Clinopodium chinense Attenuates Palmitic Acid-Induced Vascular Endothelial Inflammation and Insulin Resistance through TLR4-Mediated NF-
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B and MAPK Pathways.
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Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA).
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Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.
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Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.
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Close localization of DAP-kinase positive tumour-associated macrophages and apoptotic colorectal cancer cells.
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cMET promotes metastasis and epithelial-mesenchymal transition in colorectal carcinoma by repressing RKIP.
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Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis.
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Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1/PD-L1 axis activating intracellular AKT/mTOR pathway in tumor cells.
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Co-purification of p34cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein.
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Co-targeting CK2? and YBX1 suppresses tumor progression by coordinated inhibition of the PI3K/AKT signaling pathway.
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Co-Upregulation of 14-3-3? and P-Akt is Associated with Oncogenesis and Recurrence of Hepatocellular Carcinoma.
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Codelivery of HIF-1? siRNA and Dinaciclib by Carboxylated Graphene Oxide-Trimethyl Chitosan-Hyaluronate Nanoparticles Significantly Suppresses Cancer Cell Progression.
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Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia.
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Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells by mTOR activation through Akt-independent pathway.
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Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer.
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Colon cancer-associated transcript-1 enhances glucose metabolism and colon cancer cell activity in a high-glucose environment in vitro and in vivo.
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Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors.
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Combination of a selective cyclooxygenase-2 inhibitor with epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect.
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Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme.
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Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma.
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Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer.
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Combination of radiofrequency ablation with antiangiogenic therapy for tumor ablation efficacy: study in mice.
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Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells.
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Combination therapy using molecular-targeted drugs modulates tumor microenvironment and impairs tumor growth in renal cell carcinoma.
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Combination therapy with metformin and IL-12 to inhibit the growth of hepatic carcinoma by promoting apoptosis and autophagy in HepG2-bearing mice.
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Combination treatment of cancer cells with pan-Akt and pan-mTOR inhibitors: effects on cell cycle distribution, p-Akt expression level and radiolabelled-choline incorporation.
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Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo.
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Combination with liposome-entrapped, ends-modified raf antisense oligonucleotide (LErafAON) improves the anti-tumor efficacies of cisplatin, epirubicin, mitoxantrone, docetaxel and gemcitabine.
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Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone.
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Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer.
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Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma.
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Combined blockade of AKT/mTOR pathway inhibits growth of human hemangioma via downregulation of proliferating cell nuclear antigen.
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Combined blockade of protein kinase A and bcl-2 by antisense strategy induces apoptosis and inhibits tumor growth and angiogenesis.
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Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo.
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Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo.
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Combined effect of genetic polymorphisms of AURKA and environmental factors on oral cancer development in Taiwan.
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Combined effects of Lenvatinib and iodine-131 on cell apoptosis in nasopharyngeal carcinoma through inducing endoplasmic reticulum stress.
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Combined histomorphologic and immunohistochemical phenotype to predict the presence of vascular invasion in colon cancer.
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Combined inhibition of ACK1 and AKT shows potential toward targeted therapy against KRAS-mutant non-small-cell lung cancer.
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Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells.
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Combined inhibitory effects of celecoxib and fluvastatin on the growth of human hepatocellular carcinoma xenografts in nude mice.
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Combined LIM kinase 1 and p21-Activated kinase 4 inhibitor treatment exhibits potent preclinical antitumor efficacy in breast cancer.
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Combined microRNA-340 and ROCK1 mRNA profiling predicts tumor progression and prognosis in pediatric osteosarcoma.
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Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth.
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Combined Treatment with JFKD and Gefitinib Overcomes Drug Resistance in Non-Small Cell Lung Cancer.
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Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT.
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Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells.
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Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells.
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Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.
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Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.
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Common genetic changes in leiomyosarcoma and gastrointestinal stromal tumour: implication for ataxia telangiectasia mutated involvement.
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Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.
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Comparative analysis of co-occurring mutations of specific tumor suppressor genes in lung adenocarcinoma between Asian and Caucasian populations.
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Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9.
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Comparative analysis of the 14-3-3 gene and its expression in Echinococcus granulosus and Echinococcus multilocularis metacestodes.
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Comparative expression of zebrafish lats1 and lats2 and their implication in gastrulation movements.
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Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.
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Comparative immunohistochemical analysis of ochratoxin A tumourigenesis in rats and urinary tract carcinoma in humans; mechanistic significance of p-S6 ribosomal protein expression.
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Comparative kinome analysis to identify putative colon tumor biomarkers.
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Comparative proteome analysis of three mouse lung adenocarcinoma CMT cell lines with different metastatic potential by two-dimensional gel electrophoresis and mass spectrometry.
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Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells.
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Comparing intestinal versus diffuse gastric cancer using a PEFF-oriented proteomic pipeline.
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Comparison of Patient Susceptibility Genes Across Breast Cancer: Implications for Prognosis and Therapeutic Outcomes.
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Comparison of the PI3KCA pathway in circulating tumor cells and corresponding tumor tissue of patients with metastatic breast cancer.
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Compartmentalization and Insulin-Induced Translocations of Insulin Receptor Substrates, Phosphatidylinositol 3-Kinase, and Protein Kinase B in Rat Liver* * This work was supported by grants from the Medical Research Council and from the National Cancer Institute of Canada, and by the Cleghorn Fund at McGill University and the M. Pollack Foundation of Montreal.
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Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors.
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Complete germline deletion of the STK11 gene in a family with Peutz-Jeghers syndrome.
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Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis.
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Complete Pathologic Response of Multiple Liver Metastases and Clinical Complete Response of Rectal Cancer in a Patient with Ataxia-Telangiectasia Mutated Gene Mutations After XELOXIRI Plus Bevacizumab: A Case Report.
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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.
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Complete sequencing of full-length canine ataxia telangiectasia mutated mRNA and characterization of its putative promoter.
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Comprehensive analysis of microRNA-messenger RNA regulatory network in gemcitabine-resistant bladder cancer cells.
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Comprehensive assessment of cancer missense mutation clustering in protein structures.
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Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies.
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Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib.
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Comprehensive genomic profiling of Brazilian non-small cell lung cancer patients (GBOT 0118/LACOG0418).
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Computational analysis of benzofuran-2-carboxlic acids as potent Pim-1 kinase inhibitors.
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Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer: A functional and structural impact.
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Computational analysis of the LRRK2 interactome.
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Computational design of new protein kinase D 1 (PKD1) inhibitors: homology-based active site prediction, energy-optimized pharmacophore, docking and database screening.
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Computational Insight into p21-Activated Kinase?4 Inhibition: A Combined Ligand- and Structure-Based Approach.
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Computational Investigation of Cancer-Associated Molecular Mechanism in Aurora A (S155R) Mutation.
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Computational investigation of imidazopyridine analogs as protein kinase B (Akt1) allosteric inhibitors by using 3D-QSAR, molecular docking and molecular dynamics simulations.
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Computational modeling of the metabolic States regulated by the kinase akt.
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Computational simulation studies on the binding selectivity of Wee1 and Checkpoint kinase 1 by molecular dynamics simulation combined with free energy calculations.
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Computational studies on the binding mechanism between triazolone inhibitors and Chk1 by molecular docking and molecular dynamics.
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Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3? case.
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Computational Tools for Splicing Defect Prediction in Breast/Ovarian Cancer Genes: How Efficient Are They at Predicting RNA Alterations?
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Computationally guided identification of Akt-3, a serine/threonine kinase inhibitors: Insights from homology modelling, structure-based screening, molecular dynamics and quantum mechanical calculations.
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Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.
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Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.
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Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
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Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein.
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Conformational flexibility determines the Nf2/merlin tumor suppressor functions.
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Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential.
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Constitutive activation of glycogen synthase kinase-3beta correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer.
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Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.
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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors.
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Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma.
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Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.
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Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer.
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Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus.
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Construction of a reference material panel for detecting KRAS/NRAS/EGFR/BRAF/MET mutations in plasma ctDNA.
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Construction of phosphorylatable monoclonal antibody CC49 with a casein kinase II recognition site.
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Context Dependence of Checkpoint Kinase 1 as a Therapeutic Target for Pancreatic Cancers Deficient in the BRCA2 Tumor Suppressor.
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Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy.
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Contribution of the CK2 Catalytic Isoforms ? and ?' to the Glycolytic Phenotype of Tumor Cells.
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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
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Control of beta-catenin/Tcf-directed transcription in medulloblastoma.
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Control of centrin stability by Aurora A.
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Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.
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Controlling the master-upstream regulation of the tumor suppressor LKB1.
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Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain.
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Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
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Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.
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Coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic ser/thr kinase pim-1.
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Correction to: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.
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Correction: Different Regulation of Physiological and Tumor Angiogenesis in Zebrafish by Protein Kinase D1 (PKD1).
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Correction: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1? by Chemical Proteomics.
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Correlation of PRL3 expression with colorectal cancer progression.
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Correlations of mRNA expression and in vitro chemosensitivity to enzastaurin in freshly explanted human tumor cells.
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Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
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Corrigendum: miR-335 Acts as a Tumor Suppressor and Enhances Ionizing Radiation-Induced Tumor Regression by Targeting ROCK1.
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Cortactin Phosphorylation by Casein Kinase 2 Regulates Actin-Related Protein 2/3 Complex Activity, Invadopodia Function and Tumor Cell Invasion.
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Costunolide suppresses melanoma growth via the AKT/mTOR pathway in vitro and in vivo.
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Cot kinase plays a critical role in Helicobacter pylori-induced IL-8 expression.
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Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein.
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Could changes in the regulation of the PI3K/PKB/Akt signaling pathway and cell cycle be involved in astrocytic tumor pathogenesis and progression?
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Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships.
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Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2.
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Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.
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Covalent Aurora A regulation by the metabolic integrator coenzyme A.
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CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy.
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CpG island methylation in premalignant stages of gastric carcinoma.
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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
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CREB regulates AChE-R-induced proliferation of human glioblastoma cells.
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CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma.
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Cross-species identification of in silico microsatellite biomarkers for genetic disease.
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Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague-Dawley rats.
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Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake.
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Crosstalk between GSK-3, c-Fos, NF?B and TNF-? signaling pathways play an ambitious role in Chitosan Nanoparticles Cancer Therapy.
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Crosstalk between GSK-3?-actuated molecular cascades and myocardial physiology.
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Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses.
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Crosstalk between tumor suppressors p53 and PKC?: Execution of the intrinsic apoptotic pathways.
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Crosstalks of GSK3 signaling with the mTOR network and effects on targeted therapy of cancer.
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Cryptic deletion involving the ATM locus at 11q22.3 approximately q23.1 in B-cell chronic lymphocytic leukemia and related disorders.
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Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells.
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Crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.
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Crystal structure of the human PRPK-TPRKB complex.
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Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
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Crystal structures of the S6K1 kinase domain in complexes with inhibitors.
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CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.
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CSNK2A1 Promotes Gastric Cancer Invasion Through the PI3K-Akt-mTOR Signaling Pathway.
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CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.
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CTRP3 improves the insulin sensitivity of 3T3-L1 adipocytes by inhibiting inflammation and ameliorating insulin signalling transduction.
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Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway.
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Curcumin disrupts the Mammalian target of rapamycin-raptor complex.
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Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway.
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Curcumin induces apoptosis of upper aerodigestive tract cancer cells by targeting multiple pathways.
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Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway.
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Curcumin-induced Mitotic Spindle Defect and Cell Cycle Arrest in Human Bladder Cancer Cells is partly through Inhibition of Aurora-A.
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Curcumin: from food spice to cancer prevention.
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Curcumol inhibits lung adenocarcinoma growth and metastasis via inactivation of PI3K/AKT and Wnt/ß-catenin pathway.
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Current assessment of polo-like kinases as anti-tumor drug targets.
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Current treatment strategies for inhibiting mTOR in cancer.
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Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers.
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Cutaneous Granulomatosis and Class Switching Defect as a Presenting Sign in Ataxia-Telangiectasia: First Case from the National Iranian Registry and Review of the Literature.
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Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2.
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CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motility.
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Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase.
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CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism.
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CX-F9, a novel RSK2 inhibitor, suppresses cutaneous melanoma cells proliferation and metastasis through regulating autophagy.
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Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells.
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Cyclic adenosine 3',5'-monophosphate negatively regulates clusterin gene expression in Leydig tumor cell lines.
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Cyclic adenosine 3',5'-monophosphate-binding proteins in human ovarian cancer: correlations with clinicopathological features.
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Cyclic adenosine 3':5'-monophosphate and protein kinase activity in insulin-dependent and -independent mammary tumors.
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Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells.
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Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIP(L) and MKP-1, thereby antagonizing UV-induced apoptosis.
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Cyclic AMP-binding proteins: inverse relationship with estrogen-receptors in hormone-dependent mammary tumor regression.
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Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression.
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Cyclopenta[b]indole Derivative Inhibits Aurora B in Primary Cells.
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Cyclotherapy: protection of normal cells and unshielding of cancer cells.
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Cypermethrin-Induced Nigrostriatal Dopaminergic Neurodegeneration Alters the Mitochondrial Function:A Proteomics Study.
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Cystatin SN Affects Cell Proliferation by Regulating the ER?/PI3K/AKT/ER? Loopback Pathway in Breast Cancer.
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Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins.
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Cysteine Sulfoxides Enhance Steroid Hormone Production via Activation of the Protein Kinase A Pathway in Testis-Derived I-10 Tumor Cells.
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Cytosolic phospholipase A2? sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells.
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Cytotoxicity of alpha-tocopheryl succinate, malonate and oxalate in normal and cancer cells in vitro and their anti-cancer effects on mouse melanoma in vivo.
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D11-Mediated Inhibition of Protein Kinase CK2 Impairs HIF-1?-Mediated Signaling in Human Glioblastoma Cells.
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D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells.
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DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.
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DAP kinase links the control of apoptosis to metastasis.
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DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death.
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DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene.
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DAP-kinase--protector or enemy in apoptotic cell death.
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DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer.
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DAPK-HSF1 interaction as a positive-feedback mechanism stimulating TNF-induced apoptosis in colorectal cancer cells.
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DAPK1 as an independent prognostic marker in liver cancer.
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DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by regulating STAT3, NF-?B, and caspase-3 activation.
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DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies.
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Dasatinib Inhibits Lung Cancer Cell Growth and Patient Derived Tumor Growth in Mice by Targeting LIMK1.
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DAZAP2 acts as specifier of the p53 response to DNA damage.
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DC120, a novel and potent inhibitor of AKT kinase, induces tumor cell apoptosis and suppresses tumor growth.
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DCAMKL1 is associated with the malignant status and poor outcome in bladder cancer.
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Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy.
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Death associated protein kinase as a potential therapeutic target.
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Death associated protein kinase: from regulation of apoptosis to tumor suppressive functions and B cell malignancies.
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Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions.
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Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death.
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Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer.
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Death-Associated Protein Kinase 1 As A Promising Drug Target In Cancer and Alzheimer's Disease.
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Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.
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Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
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Death-associated protein kinase 1 suppresses hepatocellular carcinoma cell migration and invasion by upregulation of DEAD-box helicase 20.
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Death-associated protein kinase 2: Regulator of apoptosis, autophagy and inflammation.
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Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase.
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Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis.
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Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review).
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Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer.
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Deciphering signaling pathways in vivo: the Ras/Raf/MEK/ERK cascade.
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Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease1.
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Deciphering the Role of Protein Kinase D1 (PKD1) in Cellular Proliferation.
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Deconstructing mTOR complexes in regulation of Glioblastoma Multiforme and its stem cells.
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Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
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Decrease in RelA phosphorylation by inhibiting protein kinase A induces cell death in NF-kappaB-expressing and drug-resistant tumor cells.
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Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease.
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Decreased CK1? expression predicts prolonged survival in colorectal cancer patients.
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Decreased expression of 14-3-3 ?, an early event of malignant transformation of respiratory epithelium, also facilitates progression of squamous cell lung cancer.
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Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation.
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Decreased expression of LATS1 correlates with astrogliosis after spinal cord injury.
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Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation.
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Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate.
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Deficiency of 14-3-3? and 14-3-3? by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects.
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Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
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Defining the role of TORC1/2 in multiple myeloma.
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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies.
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Deleterious mis-splicing of STK11 caused by a novel single-nucleotide substitution in the 3' polypyrimidine tract of intron five.
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Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma.
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Deletion of tumor progression locus 2 attenuates alcohol-induced hepatic inflammation.
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Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas.
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Delivery of Protein Kinase A by CRISPRMAX and Its Effects on Breast Cancer Stem-Like Properties.
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Delivery of PTEN via a novel gene microcapsule sensitizes prostate cancer cells to irradiation.
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Dephosphorylation of p-ERK1/2 in relation to tumor remission after HER-2 and Raf1 blocking therapy in a conditional mouse tumor model.
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Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells.
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Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells.
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Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity.
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Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.
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Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.
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Deregulation of FOXO3A during prostate cancer progression.
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Deregulation of PI3K/Akt/mTOR Signaling Pathways by Isoflavones and its Implication in Cancer Treatment.
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Design and Development of Small-Molecule Arylaldoxime/5-Nitroimidazole Hybrids as Potent Inhibitors of MARK4: A Promising Approach for Target-Based Cancer Therapy.
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Design and discovery of small molecules targeting raf-1 kinase.
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Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors.
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Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors.
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Design and Synthesis of Novel Anti-metastatic Hypoxic Cytotoxin TX-2137 Targeting AKT Kinase.
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Design of granulatimide and isogranulatimide analogues as potential Chk1 inhibitors: Study of amino-platforms for their synthesis.
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Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors.
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Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors.
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Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors.
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Design, Synthesis and Cancer Cell Growth Inhibition Evaluation of New Aminoquinone Hybrid Molecules.
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Design, Synthesis and in Vitro Tumor Cytotoxicity Evaluation of 3,5-Diamino-N-substituted Benzamide Derivatives as Novel GSK-3? Small Molecule Inhibitors.
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Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases.
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Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
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Design, synthesis, and evaluation of 4,5,6,7-tetrahydrobenzo[d]thiazole-based novel dual kinase inhibitors of CK2 and GSK3?.
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Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
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Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics.
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Destabilization of KLF10, a tumor suppressor, relies on thr93 phosphorylation and isomerase association.
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Detecting ATM-dependent chromatin modification in DNA damage response.
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Detection of 14-3-3 sigma (?) promoter methylation as a noninvasive biomarker using blood samples for breast cancer diagnosis.
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Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay.
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Detection of clustered DNA lesions: Biological and clinical applications.
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Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma.
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Detection of Germline Variants in 450 Breast/Ovarian Cancer Families with a Multi-Gene Panel Including Coding and Regulatory Regions.
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Determinates of tumor response to radiation: tumor cells, tumor stroma and permanent local control.
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Development and biological evaluation of a novel aurora A kinase inhibitor.
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Development and characterization of protein kinase B/AKT isoform-specific nanobodies.
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Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients.
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Development for Anticancer Therapy?Small-Molecule Inhibitors Targeting Protein Kinase B.
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Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2?/CK2? interaction.
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Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization.
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Development of a stabilized form of the regulatory CK2beta subunit that inhibits cell proliferation.
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Development of an Oncogenic Driver Alteration Associated Immune-Related Prognostic Model for Stage I-II Lung Adenocarcinoma.
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Development of cell-based high throughput luminescence assay for drug discovery in inhibiting OCT4/DNA-PKcs and OCT4-MK2 interactions.
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Developmental and light regulation of tumor suppressor protein PP2A in the retina.
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DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1.
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DIABLO/SMAC mimetics selectively kill HIV-1-infected resting memory CD4+ T cells: a potential role in a cure strategy for HIV-1 infection.
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Diacritic Binding of an Indenoindole Inhibitor by CK2? Paralogs Explored by a Reliable Path to Atomic Resolution CK2?' Structures.
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Diallyl trisulfide-induced apoptosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest.
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Dibromoacetic Acid Induced Hepatotoxicity in Mice through Oxidative Stress and Toll-Like Receptor 4 Signaling Pathway Activation.
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Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: a potential target for 'two-in-one' cancer chemoimmunotherapeutics.
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Dickkopf-1 mediated tumor suppression in human breast carcinoma cells.
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Dietary vitamin C deficiency depresses the growth, head kidney and spleen immunity and structural integrity by regulating NF-?B, TOR, Nrf2, apoptosis and MLCK signaling in young grass carp (Ctenopharyngodon idella).
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Differences in symptom occurrence, severity, and distress ratings between patients with gastrointestinal cancers who received chemotherapy alone or chemotherapy with targeted therapy.
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Differences in TGF-?1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer.
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Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma.
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Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.
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Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: relationship with cell proliferation.
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Different expression of protein kinase A (PKA) regulatory subunits in normal and neoplastic thyroid tissues.
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Different phenotypes including gynecological cancer in three female patients with Peutz-Jeghers syndrome and mutations in the STK11 gene.
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Different regulation of physiological and tumor angiogenesis in zebrafish by protein kinase D1 (PKD1).
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Differential 14-3-3 sigma DNA methylation and expression in c-myc- and activated H-ras-transformed cells under r- and K-selection.
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Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism.
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Differential Akt signalling in non-seminomatous testicular germ cell tumors.
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Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma.
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Differential expression of MST4, STK25 and PDCD10 between benign prostatic hyperplasia and prostate cancer.
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Differential expression of protein kinase C isoforms in human colorectal cancers.
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Differential expression of Raf-1 protooncogene in resting and activated human leukocyte populations.
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Differential expression of the subunits of the glucose-6-phosphatase system in the clear cell type of human renal cell carcinoma - no evidence for an overexpression of protein kinase B.
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Differential Expression of the Tumor Suppressor A-Kinase Anchor Protein 12 in Human Diffuse and Pilocytic Astrocytomas Is Regulated by Promoter Methylation.
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Differential hypermethylation of death-associated protein kinase promoter in central neurocytoma and oligodendroglioma.
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Differential impact of Raf-1 kinase activity on tumor cell resistance to paclitaxel and docetaxel.
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Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation.
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Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiation.
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Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification.
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Differential protein expressions induced by adenovirus-mediated p16 gene transfer into Balb/c nude mouse.
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Differential regulation of c-Jun N-terminal kinase and NF-kappaB pathway by caffeic acid phenethyl ester in astroglial and monocytic cells.
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Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3.
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Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis.
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Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy.
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Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma.
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Differential-effects of transforming growth-factor-Beta-1 on protein-levels of p21 waf and cdk-2 and on cdk-2 kinase-activity in human rd and ccl64 mink lung-cells.
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Differentially expressed novel alternatively spliced transcript variant of tumor suppressor Stk11 gene in mouse.
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Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1.
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Digital Loop-Mediated Isothermal Amplification-Based Absolute Methylation Quantification Revealed Hypermethylated DAPK1 in Cervical Cancer Patients.
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Dimerization of Laforin is required for its optimal phosphatase activity, regulation of GSK3beta phosphorylation, and Wnt signaling.
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DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.
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Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage.
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Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.
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Discovering protein-protein interaction stabilisers by native mass spectrometry.
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Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.
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Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
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Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.
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Discovery and the structural basis of a novel p21-activated kinase 4 inhibitor.
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Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3K? and PI3K? for the treatment of PTEN-deficient cancers.
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Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693.
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Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases.
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Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor.
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Discovery of a novel class of AKT pleckstrin homology domain inhibitors.
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Discovery of highly selective CRAF inhibitors, 3-carboxamido-2H-indazole-6-arylamide: In silico FBLD design, synthesis and evaluation.
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Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.
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Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.
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Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.
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Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.
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Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
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Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors.
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Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
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Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression.
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Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.
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Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition.
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Discrete functions of GSK3? and GSK3? isoforms in prostate tumor growth and micrometastasis.
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Disrupting the Rb-Raf-1 interaction: A potential therapeutic target for cancer.
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Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression.
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Disruption of microtubule network in human monocytes induces expression of interleukin-1 but not that of interleukin-6 nor tumor necrosis factor-alpha. Involvement of protein kinase A stimulation.
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Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.
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Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.
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Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge.
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Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy.
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Dissecting the phenotypes of Plk1 inhibition in cancer cells using novel kinase inhibitory chemical CBB2001.
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Distinct cellular responses to replication stress leading to apoptosis or senescence.
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Distinct expression and activity of GSK-3? and GSK-3? in prostate cancer.
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Distinct Factors Secreted by Adipose Stromal Cells Protect the Endothelium From Barrier Dysfunction and Apoptosis.
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Distinct regulatory effect of the p34SEI-1 oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells.
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Distinct role of c-Jun N-terminal kinase isoforms in human neutrophil apoptosis regulated by tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor.
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Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.
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Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.
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Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer.
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Diverse roles of GSK-3: tumor promoter-tumor suppressor, target in cancer therapy.
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DIXDC1 promotes tumor proliferation and cell adhesion mediated drug resistance (CAM-DR) via enhancing p-Akt in Non-Hodgkin's lymphomas.
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DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile.
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DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks.
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DMB1285 [cyclopropyl-{4-[4-(4-fluorophenyl)-2-piperidin-4-yl-thiazol-5-yl]pyrimidin-2-yl}amine] suppresses tumor necrosis factor-{alpha} production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway.
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DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs.
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DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy.
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DNA Damage-Induced Protein 14-3-3 {sigma} Inhibits Protein Kinase B/Akt Activation and Suppresses Akt-Activated Cancer.
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DNA hypermethylation profiles in squamous cell carcinoma of the vulva.
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DNA methylation changes in cancer.
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DNA Replication Licensing Factors and Aurora Kinases are Linked to Aneuploidy and Clinical Outcome in Epithelial Ovarian Carcinoma.
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DNA-Damaging Anticancer Drugs - a Perspective for DNA Repair-Oriented Therapy.
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DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT.
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DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
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DNA-dependent protein kinase catalytic subunit functions in metastasis and influences survival in advanced-stage laryngeal squamous cell carcinoma.
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DNA-dependent protein kinase modulates the anti-cancer properties of silver nanoparticles in human cancer cells.
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DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
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DNA-PKcs and Ku70 are predictive markers for poor prognosis of patients with gall bladder malignancies.
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DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination.
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DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
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DNA-PKcs Emerges as Master Driver of Metastasis.
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DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery.
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DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.
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DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly.
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DNA-PKcs Inhibition Sensitizes Cancer Cells to Carbon-Ion Irradiation via Telomere Capping Disruption.
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DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-?1/Smad Signaling Pathway.
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DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia.
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DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion.
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DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis.
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DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.
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DNA-PKcs, a novel functional target of acriflavine, mediates acriflavine's p53-dependent synergistic anti-tumor efficiency with melphalan.
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DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.
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DNA-PKcs: A Multi-Faceted Player in DNA Damage Response.
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DNA-PKcs: A promising therapeutic target in human hepatocellular carcinoma?
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DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
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Docetaxel induces p53-dependent apoptosis and synergizes with farnesyl transferase inhibitor r115777 in human epithelial cancer cells.
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Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells.
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Dose dependent effects of cadmium on tumor angiogenesis.
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Dose-finding study of the checkpoint kinase 1 inhibitor, prexasertib, in Japanese patients with advanced solid tumors.
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Double trouble: when sonic hedgehog signaling meets TSC inactivation.
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Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway.
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Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer.
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Down-regulation of 14-3-3 zeta sensitizes human glioblastoma cells to apoptosis induction.
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Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation.
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Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells
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Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells.
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Down-regulation of long noncoding RNA RP11-713B9.1 contributes to the cell viability in non?small cell lung cancer (NSCLC).
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Down-regulation of microRNA-155 promotes selenium deficiency-induced apoptosis by tumor necrosis factor receptor superfamily member 1B in the broiler spleen.
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Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells.
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Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors.
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Down-regulation of succinate dehydrogenase subunit B and up-regulation of pyruvate dehydrogenase kinase 1 predicts poor prognosis in recurrent nasopharyngeal carcinoma.
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Down-regulation of the transcriptional mediator subunit Med1 contributes to the loss of expression of metastasis-associated dapk1 in human cancers and cancer cells.
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Down-regulation of the tumor suppressor protein 14-3-3sigma is a sporadic event in cancer of the breast.
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Down-regulation of TRAF4 targeting RSK4 inhibits proliferation, invasion and metastasis in breast cancer xenografts.
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Down-regulation of transient receptor potential melastatin member 7 prevents migration and invasion of renal cell carcinoma cells via inactivation of the Src and Akt pathway.
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Downregulation of 14-3-3? inhibits proliferation and migration in osteosarcoma cells.
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Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4.
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Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies.
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Downregulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in HeLa cells.
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Downregulation of Dicer enhances tumor cell proliferation and invasion.
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Downregulation of FGL2/prothrombinase delays HCCLM6 xenograft tumour growth and decreases tumour angiogenesis.
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Downregulation of GLUT3 impairs STYK1/NOK-mediated metabolic reprogramming and proliferation in NIH-3T3 cells.
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Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway.
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Downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1.
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Downregulation of homeodomain-interacting protein kinase-2 contributes to bladder cancer metastasis by regulating Wnt signaling.
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Downregulation of LKB1 suppresses Stat3 activity to promote the proliferation of esophageal carcinoma cells.
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Downregulation of lncRNA SNHG7 inhibits proliferation and invasion of nasopharyngeal carcinoma cells through repressing ROCK1.
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Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors.
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Downregulation of Pim-2 induces cell cycle arrest in the G
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Downregulation of PIM1 regulates glycolysis and suppresses tumor progression in gallbladder cancer.
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Downregulation of protein kinase CK2 activity facilitates tumor necrosis factor-?-mediated chondrocyte death through apoptosis and autophagy.
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Downregulation of rho-associated protein kinase 1 by miR-124 in colorectal cancer.
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Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.
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Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells.
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Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival.
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Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level.
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Downregulation of survivin and aurora a by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy.
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Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer.
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Doxorubicin induces cytotoxicity through upregulation of pERK-dependent ATF3.
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Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications.
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Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway.
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Drug design with Cdc7 kinase: a potential novel cancer therapy target.
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Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: inhibitors of the Wnt/beta-catenin signaling pathway as novel anticancer drugs.
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Drug discovery by formulation design and innovative drug delivery systems (DDS).
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Drug-drug interaction pharmacokinetic study with the Raf kinase inhibitor (RKI) BAY 43-9006 administered in combination with irinotecan (CPT-11) in patients with solid tumors.
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Drugging MYCN through an allosteric transition in Aurora kinase A.
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Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation.
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Dual degradation of aurora A and B kinases by the histone deacetylase inhibitor LBH589 induces G2-M arrest and apoptosis of renal cancer cells.
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Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation.
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Dual inhibition of EGFR and mTOR pathways in small cell lung cancer.
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Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia.
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Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation.
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Dual role of NO donors in the reversal of tumor cell resistance and EMT: Downregulation of the NF-?B/Snail/YY1/RKIP circuitry.
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Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.
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Dual Roles of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) in Redox-Sensitive Signaling Pathways Related to Cancer Development.
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Dual specificity of the interleukin 1- and tumor necrosis factor-activated beta casein kinase.
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Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis.
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Duodenal cancer in a young patient with Peuts-Jeghers syndrome harboring an entire deletion of the STK11 gene.
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Duplication of 7q34 in Pediatric Low-Grade Astrocytomas Detected by High-Density Single-Nucleotide Polymorphism-Based Genotype Arrays Results in a Novel BRAF Fusion Gene.
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Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways.
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Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development.
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Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.
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Dyrk1A promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis via down-regulating Spry2 and activating the ERK MAPK pathway.
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Dyrk1B overexpression is associated with breast cancer growth and a poor prognosis.
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Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours.
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Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase.
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Dysregulation of mTOR activity through LKB1 inactivation.
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Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor.
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Dysregulation of the cell survival/anti-apoptotic NF-kappaB pathway by the novel humanized BM-ca anti-CD20 mAb: implication in chemosensitization.
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Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
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E pluribus unum? The main protein kinase A catalytic subunit (PRKACA), a likely oncogene, and cortisol-producing tumors.
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E. coli expression of a soluble, active single-chain antibody variable fragment containing a nuclear localization signal.
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Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha.
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Early screening the small bowel is key to protect Peutz-Jeghers syndrome patients from surgery: a novel mutation c.243delG in STK11 gene.
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Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells.
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Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase.
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Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells.
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Editorial comment on: Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
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Effect of 14-3-3 protein induction on cell proliferation of A549 human lung adenocarcinoma.
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Effect of alisertib, an investigational aurora a kinase inhibitor on the QTc interval in patients with advanced malignancies.
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Effect of ATM-111 (G>A) Polymorphism on Cancer Risk: A Meta-Analysis.
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Effect of Atorvastatin on Wound Healing in Rats.
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Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity.
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Effect of DJ-1 overexpression on the proliferation, apoptosis, invasion and migration of laryngeal squamous cell carcinoma SNU-46 cells through PI3K/AKT/mTOR.
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Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease.
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Effect of Everolimus in Treatment of Aggressive Prolactin-Secreting Pituitary Adenomas.
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Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors.
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Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.
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Effect of MUC1/?-catenin interaction on the tumorigenic capacity of pancreatic CD133(+) cells.
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Effect of NUCKS-1 overexpression on cytokine profiling in obese women with breast cancer.
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Effect of nutrient intake on intramuscular glucose metabolism during the early growth stage in cross-bred steers (Japanese Black male?×?Holstein female).
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Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
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Effect of TNF-? on Molecules Related to the Insulin Action in Endometrial Cells Exposed to Hyperandrogenic and Hyperinsulinic Conditions Characteristics of Polycystic Ovary Syndrome.
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Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timing.
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Effect of VEGF and VEGF Trap on vascular endothelial cell signaling in tumors.
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Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101.
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Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice.
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Effects of altered ephrin-A5 and EphA4/EphA7 expression on tumor growth in a medulloblastoma mouse model.
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Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo.
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Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma.
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Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells.
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Effects of dietary tryptophan levels on antioxidant status and immunity for juvenile blunt snout bream (Megalobrama amblycephala) involved in Nrf2 and TOR signaling pathway.
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Effects of doxepin on brain-derived neurotrophic factor, tumor necrosis factor alpha, mitogen-activated protein kinase 14, and AKT1 genes expression in rat hippocampus.
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Effects of doxepin on gene expressions of Bcl-2 family, TNF-?, MAP kinase 14, and Akt1 in the hippocampus of rats exposed to stress.
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Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.
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Effects of ionizing radiation and caffeine treatment on cyclin dependent kinase complexes in V79 hamster cells.
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Effects of JNK1/2 on the inflammation cytokine TNF-?-enhanced production of MMP-3 in human dental pulp fibroblast-like cells.
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Effects of MicroRNA-132 Transfection on the Proliferation and Apoptosis of Human Liver Cancer Cells in vitro and in vivo.
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Effects of mutations in Wnt/?-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.
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Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells.
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Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1? in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro.
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Effects of pomegranate aril juice and its punicalagin on some key regulators of insulin resistance and oxidative liver injury in streptozotocin-nicotinamide type 2 diabetic rats.
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Effects of raf kinase inhibitor protein expression on metastasis and progression of human breast cancer.
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Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: an in vivo and in vitro study.
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Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis.
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Effects of rifampin, itraconazole and esomeprazole on the pharmacokinetics of alisertib, an investigational aurora a kinase inhibitor in patients with advanced malignancies.
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Effects of serum matrix on molecular interactions between drugs and target proteins revealed by giant magneto-resistive bio-sensing techniques.
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Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation.
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Effects of Sorafenib and Arsenic Trioxide on U937 and KG-1 Cell Lines: Apoptosis or Autophagy?
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Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma.
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Effects of Yixintai Pills on Myocardial Cell Apoptosis in Rats With Adriamycin-Induced Heart Failure.
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Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.
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Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of KRAS-mutant colorectal cancer.
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EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: Role of c-Jun N-terminal kinase.
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EGFR and ErbB2 differentially regulate Raf-1 translocation and activation.
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EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas.
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EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells.
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EGFR-mutant lung adenocarcinoma harboring co-mutational tumor suppressor genes predicts poor prognosis.
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EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.
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Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells.
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Elaborate ligand-based modeling reveal new submicromolar Rho kinase inhibitors.
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Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA.
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Elevated Apoptosis in the Liver of Dairy Cows with Ketosis.
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Elevated expression levels of the 14-3-3 family of proteins in lung cancer tissues.
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Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors.
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Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.
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Elevated microRNA-7 inhibits proliferation and tumor angiogenesis and promotes apoptosis of gastric cancer cells via repression of Raf-1.
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Elevated protein kinase CK2 activity in chromatin of head and neck tumors: association with malignant transformation.
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Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.
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Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-?B signaling.
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Eliminating animal facility light-at-night contamination and its effect on circadian regulation of rodent physiology, tumor growth, and metabolism: a challenge in the relocation of a cancer research laboratory.
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Elongation of (CTG)n repeats in myotonic dystrophy protein kinase gene in tumors associated with myotonic dystrophy patients.
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Elucidating binding modes of zuonin A enantiomers to JNK1 via in silico methods.
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Elucidation of Dietary Polyphenolics as Potential Inhibitor of Microtubule Affinity Regulating Kinase 4: In silico and In vitro Studies.
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Emergence of protein kinase CK2 as a key target in cancer therapy.
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Emerging functions of PRKDC in the initiation and progression of cancer.
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Emerging roles of glycogen synthase kinase 3 in the treatment of brain tumors.
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Emerging roles of microRNAs in regulating the mTOR signaling pathway during tumorigenesis.
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Emerging roles of protein kinase d1 in cancer.
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Emerging strategies for ErbB ligand-based targeted therapy for cancer.
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Emerging Therapeutic Implications of STK11 Mutation: Case Series.
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Emerging views of mitophagy in immunity and autoimmune diseases.
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Emodin suppresses growth and invasion of colorectal cancer cells by inhibiting VEGFR2.
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ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status.
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Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis.
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Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway.
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Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.
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Endoplasmic Reticulum Stress Contributes to Gefitinib-Induced Apoptosis in Glioma.
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Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
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Endostatin sensitizes p53-deficient non-small-cell lung cancer to genotoxic chemotherapy by targeting DNA-dependent protein kinase catalytic subunit.
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Endothelial p70 S6 kinase 1 in regulating tumor angiogenesis.
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Endurance Exercise Prevents Metabolic Distress-induced Senescence in the Hippocampus.
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Enhanced casein kinase II (CK II) activity in human lung tumours.
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Enhanced casein kinase II activity during mouse embryogenesis. Identification of a 110-kDa phosphoprotein as the major phosphorylation product in mouse embryos and Krebs II mouse ascites tumor cells.
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Enhanced casein kinase II activity in human tumour cell cultures.
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Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.
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Enhanced effect of geldanamycin nanocomposite against breast cancer cells growing in vitro and as xenograft with vanquished normal cell toxicity.
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Enhanced induction of apoptosis in a radio-resistant bladder tumor cell line by combined treatments with X-rays and wortmannin.
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Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type i? of protein kinase a in vivo.
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Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors.
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Enhanced therapeutic effects of doxorubicin and paclitaxel in combination with liposome-entrapped ends-modified raf antisense oligonucleotide against human prostate, lung and breast tumor models.
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Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin.
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Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3?-mediated B-cell lymphoma 2 regulation.
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Enhancement of radiosensitivity by inhibition of c-Jun N-terminal kinase activity in a Lewis lung carcinoma?bearing subcutaneous tumor mouse model.
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Enhancing Akt imaging through targeted reporter expression.
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Enhancing Gene-Knockdown Efficiency of Poly(N-isopropylacrylamide) Nanogels.
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Enigmatic MELK: The controversy surrounding its complex role in cancer.
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Enzastaurin shows preclinical antitumor activity against human transitional cell carcinoma and enhances the activity of gemcitabine.
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Enzastaurin, a protein kinase Cbeta- selective inhibitor, and its potential application as an anticancer agent in lung cancer.
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Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells.
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Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer.
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Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide?induced intestinal injury.
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Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer.
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Epidermal growth factor receptor signaling in adenocarcinomas with bronchioloalveolar components.
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Epidermal growth factor regulates protein kinase A activity in murine fibrosarcoma cells: differences between metastatic and nonmetastatic tumor cell variants.
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Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.
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Epigallocatechin gallate induce cell death and apoptosis in triple negative breast cancer cells Hs578T.
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Epigenetic changes and nuclear factor-?B activation, but not microRNA-224, downregulate Raf-1 kinase inhibitor protein in triple-negative breast cancer SUM 159 cells.
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Epigenetic changes in the DAP-kinase CpG island in pediatric lymphoma.
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Epigenetic changes of TIMP-3, GSTP-1 and 14-3-3 sigma genes as indication of status of chronic inflammation and cancer.
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Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
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Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes.
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Epigenetic regulation of death-associated protein kinase expression in primary gastric cancers from Chinese patients.
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Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice.
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Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt.
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Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor.
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Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.
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ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth.
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ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.
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Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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ERK Crosstalks with 4EBP1 to Activate Cyclin D1 Translation During Quinol-Thioether Induced Tuberous Sclerosis Renal Cell Carcinoma.
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Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A.
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Erlotinib Protects LPS-Induced Acute Lung Injury in Mice by Inhibiting EGFR/TLR4 Signaling Pathway.
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Erratum: Zare, A. et al. RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis. Cancers, 2018, 10, 184.
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Erythropoietin inhibits gluconeogenesis and inflammation in the liver and improves glucose intolerance in high-fat diet-fed mice.
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Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.
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Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.
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Establishing trusting partnerships for successful recruitment of American Indians to clinical trials.
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Estradiol suppresses phosphorylation of ER? serine 167 through upregulation of PP2A in breast cancer cells.
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Estrogen regulation of STYK1 expression in estrogen receptor-alpha negative ovarian cancer cell lines.
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Estrogen-related receptor-? promotes gallbladder cancer development by enhancing the transcription of Nectin-4.
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Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A.
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ET-18-OCH3 inhibits the phosphorylation and activation of p70 S6 kinase in MCF-7 cells.
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Etanercept Alleviates Early Brain Injury Following Experimental Subarachnoid Hemorrhage and the Possible Role of Tumor Necrosis Factor-? and c-Jun N-Terminal Kinase Pathway.
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Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitor.
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Ethyl Acetate Fraction from Persimmon (Diospyros kaki) Ameliorates Cerebral Neuronal Loss and Cognitive Deficit via the JNK/Akt Pathway in TMT-Induced Mice.
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Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways.
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ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer.
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Eukaryotic elongation factor-2 kinase (eEF2K): a potential therapeutic target in cancer.
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Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase.
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Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2.
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Evaluation of a novel approach to circulating tumor cell isolation for cancer gene panel analysis in patients with breast cancer.
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Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.
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Evaluation of cyclin-dependent kinase-like 1 expression in breast cancer tissues and its regulation in cancer cell growth.
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Evaluation of Ki-67 as prognostic factor for pediatric neuroblastoma and the possibility of molecular-targeted drugs with vascular endothelial growth factor and platelet-derived growth factor receptor.
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Everolimus plus anastrozole for female adnexal tumor of probable Wolffian origin (FATWO) with STK11 mutation.
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Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha.
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Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas.
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Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells.
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Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
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Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells.
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Evolution of PIKK family kinase inhibitors: A new age cancer therapeutics.
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Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus?positive cirrhosis.
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Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
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Exogenous activation of LKB1/AMPK signaling induces G? arrest in cells with endogenous LKB1 expression.
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Exogenous phospholipids supplementation improves growth and modulates immune response and physical barrier referring to NF-?B, TOR, MLCK and Nrf2 signaling factors in the intestine of juvenile grass carp (Ctenopharyngodon idella).
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Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs).
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Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
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Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2.
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Exploiting p70 S6 kinase as a target for ovarian cancer.
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Exploiting the MDM2-CK1? Protein-Protein Interface to Develop Novel Biologics That Induce UBL-Kinase-Modification and Inhibit Cell Growth.
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Exploration of the molecular mechanisms of cervical cancer based on mRNA expression profiles and predicted microRNA interactions.
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Exploration of the selective binding mechanism of protein kinase Aurora A selectivity via a comprehensive molecular modeling study.
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Exploring Molecular Descriptors and Fingerprints to Predict mTOR Kinase Inhibitors using Machine Learning Techniques.
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Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation.
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Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA.
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Exploring the mechanisms underlying the therapeutic effect of Salvia miltiorrhiza in diabetic nephropathy using network pharmacology and molecular docking.
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Exploring the Pivotal Role of the CK2 Hinge Region Sub-Pocket in Binding with Tricyclic Quinolone Analogues by Computational Analysis.
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Exploring the prominent performance of CX-4945 derivatives as protein kinase CK2 inhibitors by a combined computational study.
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Exploring the role of polyphenols in rheumatoid arthritis.
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Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt.
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Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements.
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Expression analysis of B-Raf oncogene in V600E-negative benign and malignant tumors of the thyroid gland: correlation with late disease onset.
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Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast.
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Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins.
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Expression and clinical significance of A-kinase anchor protein 4 in lung adenocarcinoma tissue.
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Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer.
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Expression and clinical significance of HMGB1 in human liver cancer: Knockdown inhibits tumor growth and metastasis in vitro and in vivo.
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Expression and clinical significance of the phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway in non-small cell lung carcinoma.
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Expression and Humoral Response of A-Kinase Anchor Protein 4 in Cervical Cancer.
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Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression.
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Expression and prognostic role of pan-Ras, Raf-1, pMEK1 and pERK1/2 in patients with hepatocellular carcinoma.
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Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma.
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Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma.
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Expression of 14-3-3 ? protein in normal and neoplastic canine mammary gland.
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Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome.
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Expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in esophageal cancer and their association with the clinical and pathological parameters.
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Expression of Akt (protein kinase B) and its isoforms in malignant lymphomas.
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Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors.
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Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
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Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma.
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Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues.
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Expression of Concern: A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
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Expression of Concern: Elevated microRNA-7 inhibits proliferation and tumor angiogenesis and promotes apoptosis of gastric cancer cells via repression of Raf-1.
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Expression of Concern: Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway.
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Expression of constitutively active Akt-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo.
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Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations.
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Expression of DNA-dependent protein kinase catalytic subunit in laryngeal squamous cell carcinoma and its importance.
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Expression of DNA-PKcs and BRCA1 as prognostic indicators in nasopharyngeal carcinoma following intensity-modulated radiation therapy.
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Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies.
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Expression of EBV latent antigens, mammalian target of rapamycin, and tumor suppression genes in EBV-positive smooth muscle tumors: clinical and therapeutic implications.
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Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC).
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Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues.
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Expression of glucose transporter-1, hypoxia-inducible factor-1?, phosphatidylinositol 3-kinase and protein kinase B (Akt) in relation to [(18)F]fluorodeoxyglucose uptake in nasopharyngeal diffuse large B-cell lymphoma: a case report and literature review.
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Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
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Expression of insulin-like growth factor binding protein-2 (IGFBP-2) gene in negative and positive human cytomegalovirus glioblastoma multiforme tissues.
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Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients.
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Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma.
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Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma.
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Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy.
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Expression of LATS1 contributes to good prognosis and can negatively regulate YAP oncoprotein in non-small-cell lung cancer.
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Expression of NFkB1, GADD45A and JNK1 in salivary gland carcinomas of different histotypes.
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Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways.
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Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo.
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Expression of p-AKT and p-mTOR in a large series of bronchopulmonary neuroendocrine tumors.
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Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses.
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Expression of p-Akt in ovarian serous carcinoma and its association with proliferation and apoptosis.
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Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis.
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Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases.
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Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
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Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer.
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Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas).
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Expression of Phosphorylated AMP-Activated Protein Kinase Predicts Response to Transarterial Chemoembolization in Postoperative Cases of Hepatocellular Carcinoma.
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Expression of phosphorylated extracellular signal-regulated kinase at the invasive front of hepatic colorectal metastasis.
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Expression of phosphorylated mTOR and its clinical significances in small cell lung cancer.
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Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma.
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Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis.
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Expression of PIM-1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis.
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Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis.
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Expression of protein kinase A regulatory subunits in benign and malignant human thyroid tissues: A systematic review.
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Expression of protein tyrosine kinases in head and neck squamous cell carcinomas.
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Expression of Proviral Integration Site for Moloney Murine Leukemia Virus 1 (Pim-1) Is Post-transcriptionally Regulated by Tristetraprolin in Cancer Cells.
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Expression of Raf Kinase Inhibitor Protein (RKIP) is a predictor of uveal melanoma metastasis.
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Expression of Raf kinase inhibitor protein in human hepatoma tissues by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight methods.
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Expression of Raf kinase inhibitor protein is downregulated in response to Newcastle disease virus infection to promote viral replication.
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Expression of Raf-1 kinase inhibitory protein in carcinoma of the ampulla of Vater.
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Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney.
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Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines.
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Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition.
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Expression of the zinc importer protein ZIP9/SLC39A9 in glioblastoma cells affects phosphorylation states of p53 and GSK-3? and causes increased cell migration.
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Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.
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Expression profiles of androgen independent bone metastatic prostate cancer cells indicate up-regulation of the putative serine-threonine kinase GS3955.
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Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients.
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Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells.
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Expression, association with clinicopathological features and prognostic potential of CEP55, p-Akt, FoxM1 and MMP-2 in astrocytoma.
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Expression, localization, and activity of glycogen synthase kinase 3beta during mouse skin tumorigenesis.
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Expression, localization, and phosphorylation of Akt1 in benign and malignant thyroid lesions.
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Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells.
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Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma.
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Extracellular cyclic adenosine monophosphate-dependent protein kinase A autoantibody and C-reactive protein as serum biomarkers for diagnosis of cancer in dogs.
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Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression.
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Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells.
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EZH2 Loss Drives Resistance to Carboplatin and Paclitaxel in Serous Ovarian Cancers Expressing ATM.
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Familial lymphoid neoplasms in patients with mantle cell lymphoma Familial lymphoid neoplasms in patients with mantle cell lymphoma.
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Familial pancreatic carcinoma in Jews.
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Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
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Fascaplysin Sensitizes Anti-Cancer Effects of Drugs Targeting AKT and AMPK.
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FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis.
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FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1.
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FCHO1560-571 peptide, a PKB kinase motif, inhibits tumor progression.
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Feedback autophagy activation as a key resistance factor of Ku-0060648 in colorectal cancer cells.
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Female adnexal tumors of probable Wolffian origin: morphological, immunohistochemical, and molecular analysis of 15 cases.
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Female Gender Predicts Augmented Immune Infiltration in Lung Adenocarcinoma.
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FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin ?5 subunit and ROCK1.
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FHL3 Contributes to EMT and Chemotherapy Resistance Through Up-Regulation of Slug and Activation of TGF?/Smad-Independent Pathways in Gastric Cancer.
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Findings from the Peutz-Jeghers syndrome registry of uruguay.
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Fine tuning of protein kinase C (PKC) isoforms in cancer: shortening the distance from the laboratory to the bedside.
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First international workshop of the ATM and cancer risk group (4-5 December 2019).
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First Structure of Protein Kinase CK2 Catalytic Subunit with an Effective CK2?-Competitive Ligand.
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First-in-Human Trial of the Oral Ataxia Telangiectasia and Rad3-Related Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors.
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Fish oil improves learning impairments of diabetic rats by blocking PI3K/AKT/nuclear factor-?B-mediated inflammatory pathways.
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Fish oil positively regulates anabolic signalling alongside an increase in whole-body gluconeogenesis in ageing skeletal muscle.
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FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
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Flavones and flavonols may have clinical potential as CK2 inhibitors in cancer therapy.
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Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
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Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity.
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Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor.
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Flow cytometric detection of total and serine 473 phosphorylated Akt.
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Focal adhesion kinase affects the sensitivity of human hepatocellular carcinoma cell line SMMC-7721 to tumor necrosis factor-alpha/cycloheximide-induced apoptosis by regulating protein kinase B levels.
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Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats.
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Foot-and-Mouth Disease Virus Structural Protein VP1 Destroys the Stability of TPL2 Trimer by Degradation TPL2 to Evade Host Antiviral Immunity.
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FOXO3 induces ubiquitylation of AKT through MUL1 regulation.
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Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
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FoxO3 Modulates LPS-Activated Hepatic Inflammation in Turbot (Scophthalmus maximus L.).
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FOXO3a turns the tumor necrosis factor receptor signaling towards apoptosis through reciprocal regulation of c-Jun N-terminal kinase and NF-kappaB.
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Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
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Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B.
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Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J.
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Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability.
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Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas.
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Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers.
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Frequent beta-catenin overexpression without exon 3 mutation in cutaneous lymphomas.
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Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors.
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Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma.
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Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients.
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Frequent low-level mutations of protein kinase D2 in angiolipoma.
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Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis.
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Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma.
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Frequent overexpression of aurora B kinase, a novel drug target, in non-small cell lung carcinoma patients.
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Frequent overexpression of PDK1 in primary nasopharyngeal carcinoma is associated with poor prognosis.
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Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer.
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Frequent Phosphodiesterase 11A Gene (PDE11A) Defects in Patients with Carney Complex (CNC) Caused by PRKAR1A Mutations: PDE11A May Contribute to Adrenal and Testicular Tumors in CNC as a Modifier of the Phenotype.
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Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy.
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Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
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Frogs and estivation: transcriptional insights into metabolism and cell survival in a natural model of extended muscle disuse.
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From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
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Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond.
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Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation.
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Functional analysis of the Aurora Kinase A Ile31 allelic variant in human prostate.
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Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk.
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Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency.
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Functional characterization of lysosomal interaction of Akt with VRK2.
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Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
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Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells.
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Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis.
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Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.
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Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.
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Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate.
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Fusion of ALK to the melanophilin gene MLPH in pediatric Spitz nevi.
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Fuzzy modeling and global optimization to predict novel therapeutic targets in cancer cells.
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Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity.
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GABA and 5-HT chitosan nanoparticles decrease striatal neuronal degeneration and motor deficits during liver injury.
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GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway.
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Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats.
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Galectin-3 and the skin.
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Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells.
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Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway.
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Gallic acid suppresses colon cancer proliferation by inhibiting SRC and EGFR phosphorylation.
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Galloyl benzamide-based compounds modulating tumour necrosis factor ?-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways.
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Gamabufotalin suppressed osteosarcoma stem cells through the TGF-?/periostin/PI3K/AKT pathway.
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Ganetespib: research and clinical development.
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Ganglioglioma arising in a Peutz-Jeghers patient: a case report with molecular implications.
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Gastric-type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances.
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GDC-0084 inhibits cutaneous squamous cell carcinoma cell growth.
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GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN.
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Gefitinib Inhibits Invasion and Metastasis of Osteosarcoma via Inhibition of Macrophage Receptor Interacting Serine-Threonine Kinase 2.
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Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas.
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GEM 231, a second-generation antisense agent complementary to protein kinase A RIalpha subunit, potentiates antitumor activity of irinotecan in human colon, pancreas, prostate and lung cancer xenografts.
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Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.
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Gene expression and the biological phenotype of papillary thyroid carcinomas.
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Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients.
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Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer.
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Gene Expression of the Tumour Suppressor LKB1 Is Mediated by Sp1, NF-Y and FOXO Transcription Factors.
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Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age.
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Gene expression profile by inhibiting Raf-1 protein kinase in breast cancer cells.
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Gene expression profiling during all-trans retinoic acid-induced cell differentiation of acute promyelocytic leukemia cells.
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Gene expression profiling of alpha-radiation-induced rat osteosarcomas: Identification of dysregulated genes involved in radiation-induced tumorigenesis of bone.
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Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer.
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Gene of the month: STK11.
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Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.
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Gene sequencing and expression of Raf-1 in lymphatic metastasis of hypopharyngeal carcinoma.
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Gene variant profiles and tumor metabolic activity as measured by FOXM1 expression and glucose uptake in lung adenocarcinoma.
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General Ser/Thr Kinases Pharmacophore Approach For Selective Kinase Inhibitors Search As Exemplified By Design Of Potent And Selective Aurora A Inhibitors.
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Generating Conformation-Specific Polyclonal and Monoclonal Anti-Protein Kinase C Antibodies and Anti-Active State Specific PKC Antibodies.
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Genetic Aberration Analysis in Thai Colorectal Adenoma and Early-Stage Adenocarcinoma Patients by Whole-Exome Sequencing.
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Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice.
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Genetic ablation of TAZ induces HepG2 liver cancer cell apoptosis through activating the CaMKII/MIEF1 signaling pathway.
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Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.
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Genetic alterations in hereditary breast cancer.
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Genetic analysis and clinical description of Greek patients with Peutz-Jeghers syndrome: Creation of a National Registry.
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Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.
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Genetic Ancestry Correlations with Driver Mutations Suggest Complex Interactions between Somatic and Germline Variation in Cancer.
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Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.
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Genetic Causes of Rare Pediatric Ovarian Tumors.
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Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
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Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.
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Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex.
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Genetic model of transformation and neoplastic progression in laryngeal epithelium.
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Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
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Genetic Perturbation of Pyruvate Dehydrogenase Kinase 1 Modulates Growth, Angiogenesis and Metabolic Pathways in Ovarian Cancer Xenografts.
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Genetic Predisposition to Breast and Ovarian Cancers: How Many and Which Genes to Test?
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Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population.
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Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
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Genetic, structural, and molecular insights into the function of ras of complex proteins domains.
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Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
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Genistein inhibits radiation-induced invasion and migration of glioblastoma cells by blocking the DNA-PKcs/Akt2/Rac1 signaling pathway.
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Genistein sensitizes glioblastoma cells to carbon ions via inhibiting DNA-PKcs phosphorylation and subsequently repressing NHEJ and delaying HR repair pathways.
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Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer
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Genome variation in colorectal cancer patient with liver metastasis measured by whole-exome sequencing.
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Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models.
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Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.
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Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.
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Genome-wide expression profile of sporadic gastric cancers with microsatellite instability.
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Genome-wide landscapes of human local adaptation in Asia.
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Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.
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Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells.
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Genomic Analysis of Pigmented Epithelioid Melanocytomas Reveals Recurrent Alterations in PRKAR1A, and PRKCA Genes.
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Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma.
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Genomic and sequence variants of protein kinase A regulatory subunit type 1? (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.
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Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary.
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Genomic Database Analysis for Head and Neck Cancer Prevention Targets: MTOR Signal Transduction Pathway.
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Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to necroptosis.
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Genomic instability--an evolving hallmark of cancer.
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Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors.
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Genomics of benign adrenocortical tumors.
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Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution.
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Germline and Somatic NF1 Alterations Are Linked to Increased HER2 Expression in Breast Cancer.
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Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia.
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Germline mutation in the STK11 gene in a girl with an ovarian Sertoli cell tumour.
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Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers.
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Germline USP8 Mutation Associated With Pediatric Cushing Disease and Other Clinical Features: A New Syndrome.
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Ghrelin accelerates wound healing through GHS-R1a-mediated MAPK-NF-?B/GR signaling pathways in combined radiation and burn injury in rats.
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Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion.
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Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells.
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Gingival epithelial cells support osteoclastogenesis by producing receptor activator of nuclear factor kappa B ligand via protein kinase A signaling.
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Ginsenoside Rb1 attenuates intestinal ischemia/reperfusion?induced inflammation and oxidative stress via activation of the PI3K/Akt/Nrf2 signaling pathway.
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Ginsenoside Rb1 exerts antidepressant-like effects via suppression inflammation and activation of AKT pathway.
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Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway.
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Gli promotes tumor progression through regulating epithelial-mesenchymal transition in non-small-cell lung cancer.
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GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia.
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Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in Paclitaxel-Resistant Ovarian Cancer Cells.
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Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: Rationale for lower dosage in Asia.
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Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts.
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GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population.
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Glucocorticoid-induced degradation of glycogen synthase kinase-3 protein is triggered by serum- and glucocorticoid-induced protein kinase and Akt signaling and controls beta-catenin dynamics and tight junction formation in mammary epithelial tumor cells.
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Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
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Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy.
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Glucose variability aggravates cardiac fibrosis by altering AKT signalling path.
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Glycogen synthase 3 (GSK-3) regulation of PD-1 expression and and its therapeutic implications.
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Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.
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Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation.
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Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).
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Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2016-2019).
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Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.
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Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.
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Glycogen synthase kinase 3 beta: can it be a target for oral cancer.
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Glycogen synthase kinase 3 in Wnt signaling pathway and cancer.
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Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner.
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Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.
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Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.
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Glycogen synthase kinase 3: a key regulator of cellular fate.
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Glycogen synthase kinase 3? inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling.
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Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism.
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Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.
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Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription.
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Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization.
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Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles.
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Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review.
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Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as new lead to Treat Breast and Ovarian Cancer.
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Glycogen synthase kinase-3 (GSK-3) inhibitors reach the clinic.
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Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics.
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Glycogen synthase kinase-3 and alternative splicing.
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Glycogen synthase kinase-3 and cancer: good cop, bad cop?
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Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions.
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Glycogen synthase kinase-3 and leukemia: restoring the balance.
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Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses.
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Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking.
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Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response.
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Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis.
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Glycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression.
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Glycogen synthase kinase-3 mediates endothelial cell activation by tumor necrosis factor-alpha.
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Glycogen synthase kinase-3?, NF-?B signaling, and tumorigenesis of human osteosarcoma.
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Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53.
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Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse.
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Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells.
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Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells.
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Glycogen synthase kinase-3beta regulates astrocytic differentiation of U87-MG human glioblastoma cells.
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Glycogen synthase kinase-3beta suppresses tumor necrosis factor-alpha expression in cardiomyocytes during lipopolysaccharide stimulation.
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Glycogen synthase kinase-3beta suppression eliminates tumor necrosis factor-related apoptosis-inducing ligand resistance in prostate cancer.
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Glycogen synthase kinase-3beta, or a link between amyloid and tau pathology?
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Glycogen Synthase Kinase-3{beta}: A Prognostic Marker and a Potential Therapeutic Target in Human Bladder Cancer.
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Glycogen synthase kinases: Moonlighting proteins with theranostic potential in cancer.
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Granulocyte-macrophage colony-stimulating factor stimulates the metastatic properties of Lewis lung carcinoma cells through a protein kinase A signal-transduction pathway.
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Grape Proanthocyanidin Inhibit Pancreatic Cancer Cell Growth In Vitro and In Vivo through Induction of Apoptosis and by Targeting the PI3K/Akt Pathway.
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Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype.
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Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury.
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Growth factor receptor expression in human gastroenteropancreatic neuroendocrine tumours.
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Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer.
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Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V 600 E) B-RAF.
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GSK-3 - at the crossroads of cell death and survival.
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GSK-3 and miRs: Master regulators of therapeutic sensitivity of cancer cells.
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GSK-3 and mitochondria in cancer cells.
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GSK-3 as potential target for therapeutic intervention in cancer.
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GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
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GSK-3 inhibitor inhibits cell proliferation and induces apoptosis in human osteosarcoma cells.
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GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma.
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GSK-3 Inhibitors: A Double-Edged Sword? - An Update on Tideglusib.
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GSK-3 Inhibitors: A new class of drugs for Alzheimer's Disease Treatment.
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GSK-3 inhibitors: discoveries and developments.
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GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.
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GSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma.
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GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration.
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GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.
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GSK-3: a multifaceted player in acute leukemias.
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GSK-3: An important kinase in colon and pancreatic cancers.
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GSK-3? in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer.
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GSK-3? in Pancreatic Cancer: Spotlight on 9-ING-41, Its Therapeutic Potential and Immune Modulatory Properties.
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GSK-3? Inhibition in Drug-Resistant CML Cells Promotes Susceptibility to NK Cell-Mediated Lysis in an NKG2D- and NKp30-Dependent Manner.
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GSK-3? promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-?B.
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GSK-3? regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1?.
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GSK-3? signaling determines autophagy activation in the breast tumor cell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in response to proteasome inhibition.
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GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression.
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GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.
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GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models.
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GSK3 and miRNA in neural tissue: From brain development to neurodegenerative diseases.
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GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4.
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GSK3 suppression upregulates ?-catenin and c-Myc to abrogate KRas-dependent tumors.
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GSK3? and CREB3 gene expression profiling in benign and malignant salivary gland tumors.
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GSK3? controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug.
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GSK3? negatively regulates HIF1? mRNA stability via nucleolin in the MG63 osteosarcoma cell line.
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GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer.
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GSK3beta regulates differentiation and growth arrest in glioblastoma.
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Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.
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Hainanerectamines A-C, alkaloids from the Hainan sponge Hyrtios erecta.
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Haploinsufficiency of STK11 and neighboring genes cause a contiguous gene syndrome including Peutz-Jeghers phenotype.
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Harvey Cushing Treated the First Known Patient With Carney Complex.
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HCC development is associated to peripheral insulin resistance in a mouse model of NASH.
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HDAC inhibitor entinostat restores responsiveness of letrozole resistant MCF-7Ca xenografts to AIs through modulation of Her-2.
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Head-to-head comparison of the impact of Aurora A, Aurora B, Repp86, CDK1, CDK2 and Ki67 expression in two of the most relevant gynaecological tumor entities.
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Health risks for ataxia-telangiectasia mutated heterozygotes: A systematic review, Meta-analysis and evidence-based guideline.
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Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
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Heat shock protein 90 (hsp90) expression and breast cancer.
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Heat-Processed Scutellariae Radix Protects Hepatic Inflammation through the Amelioration of Oxidative Stress in Lipopolysaccharide-Induced Mice.
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Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.
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Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model.
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Hepatic B cell leukemia-3 suppresses chemically-induced hepatocarcinogenesis in mice through altered MAPK and NF-?B activation.
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Hepatic Preconditioning Using Lipopolysaccharide: Association With Specific Negative Regulators of the Toll-Like Receptor 4 Signaling Pathway.
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Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis.
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Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression.
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HER-2/AKT expression in upper urinary tract urothelial carcinoma: prognostic implications.
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Herbal cake-partitioned moxibustion inhibits colonic autophagy in Crohn's disease via signaling involving distinct classes of phosphatidylinositol 3-kinases.
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Hereditary predisposition to cancers of the digestive tract, breast, gynecological and gonadal: Focus on the Peutz-Jeghers.
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Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis.
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Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein-Barr virus encoded latent membrane protein 1.
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Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.
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Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms.
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HIF-1: upstream and downstream of cancer metabolism.
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HIF-1? and RKIP: a computational approach for pancreatic cancer therapy.
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HIF-1? antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.
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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
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High cytotoxic T-lymphocyte-associated antigen 4 and phospho-Akt expression in tumor samples predicts poor clinical outcomes in ipilimumab-treated melanoma patients.
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High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors.
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High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis.
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High expression of integrin-linked kinase predicts aggressiveness and poor prognosis in patients with gastric cancer.
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High expression of PFTK1 in cancer cells predicts poor prognosis in colorectal cancer.
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High expression of PIM2 induces HSC proliferation in myelodysplastic syndromes via the IDH1/HIF1-? signaling pathway.
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High expression of PRKDC promotes breast cancer cell growth via p38 MAPK signaling and is associated with poor survival.
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High frequency of DAP-kinase gene promoter methylation in colorectal cancer specimens and its identification in serum.
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High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients.
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High level of visfatin and the activation of Akt and ERK1/2 signaling pathways are associated with endometrium malignant transformation in polycystic ovary syndrome.
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High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer.
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High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4.
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High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma.
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High PKD2 predicts poor prognosis in lung adenocarcinoma via promoting Epithelial-mesenchymal Transition.
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High Raf-1 kinase activity protects human tumor cells against paclitaxel-induced cytotoxicity.
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High salinity induced expression profiling of differentially expressed genes in shrimp (Penaeus monodon).
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High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.
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High-fat Western diet-induced obesity contributes to increased tumor growth in mouse models of human colon cancer.
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High-Refined-Carbohydrate and High-Fat Diets Induce Comparable Hepatic Tumorigenesis in Male Mice.
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High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer.
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High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.
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Higher frequency of certain cancers in LRRK2 G2019S mutation carriers with Parkinson disease: a pooled analysis.
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Higher PKD3 expression in hepatocellular carcinoma (HCC) tissues predicts poorer prognosis for HCC patients.
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Higher tumor protein kinase D1 correlates with increased tumor size, BCLC stage, CA199 level, AFP level and worse overall survival in hepatocellular carcinoma patients.
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Highly oxidized low-density lipoprotein mediates activation of monocytes but does not confer interleukin-1? secretion nor interleukin-15 transpresentation function.
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Highly sensitive saturation labeling reveals changes in abundance of cell cycle-associated proteins and redox enzyme variants during oocyte maturation in vitro.
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Hinokitiol reduces tumor metastasis by inhibiting heparanase via extracellular signal-regulated kinase and protein kinase B pathway.
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HIPK2 and cancer cell resistance to therapy.
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HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.
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Hipk2 cooperates with p53 to suppress ?-ray radiation-induced mouse thymic lymphoma.
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HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity.
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HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.
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HIPK2 expression in progression of cutaneous epithelial neoplasm.
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HIPK2 inhibits cell metastasis and improves chemosensitivity in esophageal squamous cell carcinoma.
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HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer.
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HIPK2 knock-down compromises tumor cell efficiency to repair damaged DNA.
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HIPK2 modulates p53 activity towards pro-apoptotic transcription.
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HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma.
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HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels.
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HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA.
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HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
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HIPK2 role in the tumor-host interaction: Impact on fibroblasts transdifferentiation CAF-like.
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HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1?.
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HIPK2-A therapeutical target to be (re)activated for tumor suppression: Role in p53 activation and HIF-1alpha inhibition.
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HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis.
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Hippo Signaling Controls NLR Family Pyrin Domain Containing 3 Activation and Governs Immunoregulation of Mesenchymal Stem Cells in Mouse Liver Injury.
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Histamine amplifies immune response of gingival fibroblasts.
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Histone deacetylase 1 promotes glioblastoma cell proliferation and invasion via activation of PI3K/AKT and MEK/ERK signaling pathways.
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HMGA2 Inhibits Apoptosis through Interaction with ATR-CHK1 Signaling Complex in Human Cancer Cells.
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Homeodomain-interacting protein kinase (Hipk) phosphorylates the small SPOC family protein Spenito.
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Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation.
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Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.
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Homeodomain-interacting protein kinase 2 regulates DNA damage response through interacting with heterochromatin protein 1?.
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Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer.
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Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis.
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Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
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Homeodomain-interacting Protein Kinase-2 Stabilizes p27kip1 by Its Phosphorylation at Serine 10 and Contributes to Cell Motility.
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Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome.
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Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.
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Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.
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Homozygous deletions scanning in tumor cell lines detects previously unsuspected loci.
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Hormone-activated nuclear receptors inhibit the stimulation of the JNK and ERK signalling pathways in endothelial cells.
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Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.
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Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.
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How autophagy controls the intestinal epithelial barrier.
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How cells switch HIPK2 on and off.
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How does intestinal-type intraductal papillary mucinous neoplasm emerge? CDX2 plays a critical role in the process of intestinal differentiation and progression.
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HPV infection and EGFR activation/alteration in HIV-infected East African patients with conjunctival carcinoma.
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HPV16 E6 upregulates Aurora A expression.
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Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis.
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Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.
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HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasion.
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Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation.
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HTBPI, an active phenanthroindolizidine alkaloid, inhibits liver tumorigenesis by targeting Akt.
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Huachansu Capsule inhibits the proliferation of human gastric cancer cells via Akt/mTOR pathway.
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Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
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Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression.
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Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.
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Human endometrial proteins with cyclic changes in the expression during the normal menstrual cycle: characterization by protein sequence analysis.
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Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.
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Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.
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Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.
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Human Ku70/80 associates physically with telomerase through interaction with hTERT.
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Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
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Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.
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Human papillomavirus 16 E6 increases the radiosensitivity of p53-mutated cervical cancer cells, associated with up-regulation of aurora A.
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Human papillomavirus and gene mutations in head and neck squamous carcinomas.
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Human tumors associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease!
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Hunk/Mak-v is a negative regulator of intestinal cell proliferation.
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Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells.
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Hydrodynamics-based transfection of plasmid encoding receptor activator for nuclear factor kappa B-Fc protects against hepatic ischemia/reperfusion injury in mice.
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Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase.
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Hydrogen peroxide signaling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase.
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Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.
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Hyperbaric oxygen increases glioma cell sensitivity to antitumor treatment with a novel isothiourea derivative in vitro.
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Hyperglycemia triggers HIPK2 protein degradation.
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Hyperhomocysteinemia inhibits tibial fracture healing in rats through PI3K/AKT signaling pathway.
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Hypermethylation of death-associated protein (DAP) kinase CpG island is frequent not only in B-cell but also in T- and natural killer (NK)/T-cell malignancies.
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Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma.
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Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression.
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Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.
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Hypermethylation of the death-associated protein kinase CpG island in canine B-cell lymphoid tumors.
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Hypermethylation-mediated partial transcriptional silencing of DAP-kinase gene in bladder cancer.
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Hypertonicity activates GSK3beta in tumor cells.
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Hypomethylation of the 14-3-3? promoter leads to increased expression in non-small cell lung cancer.
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Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice.
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Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma.
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Hypoxia promotes tumor cell motility via RhoA and ROCK1 signaling pathways.
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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.
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Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation.
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Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
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Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis.
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Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells.
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I?B kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
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IC261 suppresses progression of hepatocellular carcinoma in a casein kinase 1 ?/? independent manner.
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ICAM3 mediates inflammatory signaling to promote cancer cell stemness.
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Identification and Biological Evaluation of CK2 Allosteric Fragments through Structure-Based Virtual Screening.
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Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains.
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Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5.
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Identification and Characterization of a Small Inhibitory Peptide That Can Target DNA-PKcs Autophosphorylation and Increase Tumor Radiosensitivity.
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Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.
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Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor.
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Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease.
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IDENTIFICATION AND EXPRESSION ANALYSIS OF TWO 14-3-3 PROTEINS IN THE MOSQUITO Aedes aegypti, AN IMPORTANT ARBOVIRUSES VECTOR.
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Identification and further development of potent TBK1 inhibitors.
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Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay.
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Identification and validation of key genes associated with non-small-cell lung cancer.
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Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer.
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Identification of 14-3-3? gene as a novel miR-152 target using a proteome-based approach.
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Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
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Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity.
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Identification of a novel function of CX-4945 as a splicing regulator.
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Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.
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Identification of a novel mRNA species of the LKB1/STK11 Peutz-Jeghers serine/threonine kinase.
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Identification of a novel potent, selective and cell permeable inhibitor of protein kinase CK2 from the NIH/NCI Diversity Set Library.
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Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3.
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Identification of a nuclear protein that promotes NF-kappaB activation.
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Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.
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Identification of a TRAF (TNF receptor-associated factor) gene in Caenorhabditis elegans.
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Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1? by Chemical Proteomics.
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Identification of a Wnt/beta-catenin signaling pathway in human thyroid cells.
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Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE.
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Identification of Aurora Kinase A as a Biomarker for Prognosis in Obesity Patients with Early Breast Cancer.
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Identification of BRAF inhibitors through in silico screening.
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Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry.
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Identification of CK2 inhibitors with new scaffolds by a hybrid virtual screening approach based on Bayesian model; pharmacophore hypothesis and molecular docking.
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Identification of DAPK1 Promoter Hypermethylation as a Biomarker for Intra-Epithelial Lesion and Cervical Cancer: A Meta-Analysis of Published Studies, TCGA, and GEO Datasets.
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Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1.
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Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells.
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Identification of dual kinase inhibitors of CK2 and GSK3?: combined qualitative and quantitative pharmacophore modeling approach.
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Identification of dysregulated microRNAs in canine malignant melanoma.
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Identification of Ellagic Acid as Potent Inhibitor of Protein Kinase CK2: A Successful Example of a Virtual Screening Application.
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Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells.
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Identification of glucocorticoid-induced leucine zipper as a key regulator of tumor cell proliferation in epithelial ovarian cancer.
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Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.
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Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.
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Identification of Hipk2 as an essential regulator of white fat development.
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Identification of inhibitors against p90 ribosomal S6 kinase 2 (RSK2) through structure-based virtual screening with the inhibitor-constrained refined homology model.
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Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer.
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Identification of molecular targets for dietary energy restriction prevention of skin carcinogenesis: an idea cultivated by Edward Bresnick.
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Identification of multiple repeat sequences and transcription-related elements within introns 4, 8 and 9 of human Raf-1.
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Identification of new biomarkers for clinical trials of Hsp90 inhibitors.
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Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach.
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Identification of novel cellular targets in biliary tract cancers using global gene expression technology.
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Identification of novel human tumor cell-specific CaMK-II variants.
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Identification of novel metastasis suppressor signaling pathways for breast cancer.
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Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics.
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Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.
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Identification of NUCKS1 as a putative oncogene and immunodiagnostic marker of hepatocellular carcinoma.
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Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing.
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Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2.
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Identification of Skt11-regulated genes in chondrocytes by integrated bioinformatics analysis.
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Identification of small-molecule inhibitors of protein kinase B (PKB/AKT) in an AlphaScreenTM high-throughput screen.
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Identification of Somatic Mutations in Dementia-related Genes in Cancer Patients.
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Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas.
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Identification of the auto-inhibitory domains of Aurora-A kinase.
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Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.
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Identification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated with an Immunosuppressive Tumor Microenvironment.
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Identification of the nuclear localization domain of salt-inducible kinase.
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Identification of unique heterozygous germline mutation, STK11 (p.F354L), in a child with encapsulated follicular variant of papillary thyroid carcinoma within 6 months of completing treatment for neuroblastoma.
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Identified a disintegrin and metalloproteinase with thrombospondin motifs 6 serve as a novel gastric cancer prognostic biomarker by bioinformatics analysis.
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Identifying Crosstalk between Raf Kinase Inhibitor Protein and Systemic Lupus Erythematosus.
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Identifying crosstalk of mTOR signaling pathway of lobular breast carcinomas.
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IDH1 immunohistochemistry reactivity and mosaic IDH1 or IDH2 somatic mutations in pediatric sporadic enchondroma and enchondromatosis.
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IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation.
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IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
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IGF-II Producing Hepatocellular Carcinoma Treated with Sorafenib: Metabolic Complications and a Foresight to Molecular Targeting Therapy to the IGF Signal.
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IkappaBalpha is essential for maintaining basal c-Jun N-terminal kinase (JNK) activation and regulating JNK-mediated resistance to tumor necrosis factor cytotoxicity in L929 cells.
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IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells.
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IL-6 stabilizes Twist and enhances tumor cell motility in head and neck cancer cells through activation of casein kinase 2.
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IL-8 protects prostate cancer cells from GSK-3?-induced oxidative stress by activating the mTOR signaling pathway.
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Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity.
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ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth.
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Imbalance in Protein Thiol Redox Regulation and Cancer-Preventive Efficacy of Selenium.
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Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt.
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Immune checkpoint inhibitors in oncogene-addicted non-small cell lung cancer: a systematic review and meta-analysis.
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Immuno-Affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance.
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Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
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Immunocytochemical detection of lung cancer cells with monoclonal antibodies to 14-3-3 proteins.
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Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis.
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Immunohistochemical analysis of the mammalian target of rapamycin signalling pathway in extramammary Paget's disease.
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Immunohistochemical analysis of the mTOR pathway in intrahepatic cholangiocarcinoma.
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Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.
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Immunohistochemical detection of Raf kinase inhibitor protein in normal cervical tissue and cervical cancer tissue.
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Immunohistochemical detection of the Raf kinase inhibitor protein in nonneoplastic gastric tissue and gastric cancer tissue.
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Immunohistochemical evaluation of ROCK activation in invasive breast cancer.
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Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis.
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Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.
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Immunohistochemical expression of 14-3-3 sigma protein in various histological subtypes of uterine cervical cancers.
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Immunohistochemical localisation of 14-3-3 sigma protein in normal canine tissues.
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Immunologically defined subclasses of the protein kinase CK2 beta-subunit in prostate carcinoma cell lines.
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Immunoreactivity for prostate specific antigen and Ki67 differentiates subgroups of prostate cancer related to outcome.
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Impact of E6-associated protein on the proliferation and invasion of prostate cancer cells in bone metastasis.
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Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy.
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Impact of KRAS and TP53 Co-Mutations on Outcomes After First-Line Systemic Therapy Among Patients With STK11-Mutated Advanced Non-Small-Cell Lung Cancer.
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Impact of Polymorphisms in Casein Kinase 1 Epsilon and Environmental Factors in Oral Cancer Susceptibility.
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Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.
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Impairment of Hypoxia-Induced CA IX by Beta-Blocker Propranolol-Impact on Progression and Metastatic Potential of Colorectal Cancer Cells.
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Implication of 14-3-3? and 14-3-3?/? in proteasome inhibition-induced apoptosis of glioma cells.
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Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells.
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Implication of ZNF217 in accelerating tumor development and therapeutically targeting ZNF217-induced PI3K-AKT signaling for the treatment of metastatic osteosarcoma.
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Implications of Splicing Alterations in the Onset and Phenotypic Variability of a Family with Subclinical Manifestation of Peutz-Jeghers Syndrome: Bioinformatic and Molecular Evidence.
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Implications of tyrosine phosphoproteomics in cervical carcinogenesis.
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In MMTV-Her-2/neu transgenic mammary tumors the absence of caveolin-1(-/-) alters PTEN and NHERF1 but not ?-catenin expression.
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In silico analysis of the association of hsa-miR-16 expression and cell survival in MDA-MB-231 breast cancer cells subjected to photodynamic therapy.
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In silico identification of novel kinase inhibitors by targeting B-Raf(v660e) from natural products database.
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In silico studies on p21-activated kinase 4 inhibitors: comprehensive application of 3D-QSAR analysis, molecular docking, molecular dynamics simulations, and MM-GBSA calculation.
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In Silico-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma.
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In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.
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In Vitro and in Silico Evaluation of Bikaverin as a Potent Inhibitor of Human Protein Kinase CK2.
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In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor.
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In vitro anti-bacterial activity and network pharmacology analysis of Sanguisorba officinalis L. against Helicobacter pylori infection.
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In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.
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In vitro selection of adenine-dependent ribozyme against Tpl2/Cot oncogene.
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In Vitro Studies of Novel PRKAR1A Mutants that Extend the Predicted RI? Protein Sequence into the 3'-Untranslated Open Reading Frame: Proteasomal Degradation Leads to RI? Haploinsufficiency and Carney Complex.
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In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
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In Vivo Evaluation of Combined CK2 Inhibition and Irradiation in Human WiDr Tumours.
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In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin.
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In vivo siRNA distribution and pharmacokinetics assessed by nuclear imaging are modulated according to radiolabelling site.
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In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer.
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Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells.
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Inactivation of homeodomain-interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53-dependent E-cadherin expression.
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Inactivation of Lkb1 in postnatal chondrocytes leads to epiphyseal growth-plate abnormalities and promotes enchondroma-like formation.
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Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma.
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Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers.
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Incidence and prognostic factors of clinically meaningful toxicities of kinase inhibitors in older patients with cancer: The PreToxE study.
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Incidence, mechanism and prognostic value of activated AKT in pancreas cancer.
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Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses.
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Increased Activated Akt Expression in Renal Cell Carcinomas and Prognosis.
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Increased Akt and phosphorylated Akt expression are associated with malignant biological features of prostate cancer in Japanese men.
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Increased cortical neuronal survival during liver injury: effect of gamma aminobutyric acid and 5-HT chitosan nanoparticles.
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Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas.
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Increased Expression of p-GSK3? Predicts Poor Survival in T -III/IV Stage OSCC Patients.
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Increased neuronal survival in the brainstem during liver injury: role of ?-aminobutyric acid and serotonin chitosan nanoparticles.
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Increased phospho-AKT (Ser(473)) expression in bronchial dysplasia: implications for lung cancer prevention studies.
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Increased phospho-AKT is associated with loss of the androgen receptor during the progression of N-methyl-N-nitrosourea-induced prostate carcinogenesis in rats.
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Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer.
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Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer.
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Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.
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Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.
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Increased transferrin receptor expression following 11q23 deletion as a mechanism of malignant progression in chronic lymphocytic leukemia.
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Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments.
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Individual differences in chromosomal aberrations after in vitro irradiation of cells from healthy individuals, cancer and cancer susceptibility syndrome patients.
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Individual Radiosensitivity Assessment of the Families of Ataxia-Telangiectasia Patients by G2-Checkpoint Abrogation.
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Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells.
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Inducible expression of protein kinase CK2 in mammalian cells. Evidence for functional specialization of CK2 isoforms.
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Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer.
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Induction and activation of the p53 pathway: a role for the protein kinase CK2?
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Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors.
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Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway.
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Induction of apoptosis in human leukemia cells through an intrinsic pathway by cathachunine, a unique alkaloid isolated from Catharanthus roseus.
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Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.
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Induction of Huh?7 cell apoptosis by HCV core proteins via CK1??p53?Bid signaling pathway.
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Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation.
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Induction of raf-1 protein immunoreactivity in guinea pig hippocampal slices during the in vitro maintenance.
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Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment.
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Induction of strong antitumor immunity by an HSV-2-based oncolytic virus in a murine mammary tumor model.
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Inferring the functional effects of mutation through clusters of mutations in homologous proteins.
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Inflamed snail speeds metastasis.
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Inflammaging and Skeletal Muscle: Can Protein Intake Make a Difference?
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Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets.
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Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta.
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Inflammation-induced GluA1 trafficking and membrane insertion of Ca(2+) permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A.
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Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.
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Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells.
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Influence of chk1 and plk1 silencing on radiation- or cisplatin-induced cytotoxicity in human malignant cells.
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Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters.
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Influence of indomethacin and difluoromethylornithine on human tumour growth in nude mice.
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Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy.
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Inhibiting casein kinase 2 overcomes paclitaxel resistance in gastric cancer.
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Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model.
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Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis.
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Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide.
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Inhibition of AKT in Human Pancreatic, Renal and Colorectal Cancer Cells by Four Cardiac Hormones.
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Inhibition of AKT signaling by supercritical CO2 extract of mango ginger (Curcuma amada Roxb.) in human glioblastoma cells.
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Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells.
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Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy.
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Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.
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Inhibition of Aurora A and Aurora B Is Required for the Sensitivity of HPV-Driven Cervical Cancers to Aurora Kinase Inhibitors.
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Inhibition of Aurora Kinase A by Alisertib Reduces Cell Proliferation and Induces Apoptosis and Autophagy in HuH-6 Human Hepatoblastoma Cells.
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Inhibition of bone morphogenetic protein receptor 2 suppresses pancreatic ductal adenocarcinoma growth by regulating GRB2/PI3K/AKT axis.
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Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx.
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Inhibition of c-Jun N-terminal kinase sensitizes tumor cells to flavonoid-induced apoptosis through down-regulation of JunD.
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Inhibition of calcium-calmodulin-dependent kinase II suppresses cardiac fibroblast proliferation and extracellular matrix secretion.
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Inhibition of Cancer Invasion and Metastasis by Targeting the Molecular Chaperone Heat-shock Protein 90.
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Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice.
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Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death.
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Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells.
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Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
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Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor.
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Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe.
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Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension.
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Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer.
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Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG12D/Pdx-1-Cre Mice.
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Inhibition of CK2 enhances UV-triggered apoptotic cell death in lung cancer cell lines.
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Inhibition of CK2? down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells.
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Inhibition of CK2? down-regulates Notch1 signalling in lung cancer cells.
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Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma.
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Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway.
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Inhibition of endothelial cell migration through the down?regulation of MMP-9 by A-kinase anchoring protein 12.
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Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction.
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Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma.
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Inhibition of G-protein-coupled Receptor Kinase 2 (GRK2) Triggers the Growth-promoting Mitogen-activated Protein Kinase (MAPK) Pathway.
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Inhibition of gastric cancer angiogenesis by vector-based RNA interference for Raf-1.
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Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation.
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Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells.
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Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells.
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Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3.
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Inhibition of glycogen synthase kinase-3.
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Inhibition of glycolysis enhances cisplatin-induced apoptosis in ovarian cancer cells.
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Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents.
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Inhibition of GSK-3? activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling.
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Inhibition of GSK3?/? impairs the progression of HNSCC.
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Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma.
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Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis.
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Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2.
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Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.
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Inhibition of JNK and p38 MAPK-mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin-induced diabetic cardiomyopathy.
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Inhibition of liver trans-sulphuration pathway by propargylglycine mimics gene expression changes found in the mammary gland of weaned lactating rats: role of glutathione.
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Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer.
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Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs.
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Inhibition of MKK7-JNK by the TOR Signaling Pathway Regulator-Like Protein Contributes to Resistance of HCC cells to TRAIL-Induced Apoptosis.
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Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors.
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Inhibition of non-neuronal alpha7-nicotinic receptor reduces tumorigenicity in A549 NSCLC xenografts.
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Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines.
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Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3? and osteopontin.
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Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells.
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Inhibition of phosphoinositide 3-kinase/Akt pathway decreases hypoxia inducible factor-1? expression and increases therapeutic efficacy of paclitaxel in human hypoxic gastric cancer cells.
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Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis.
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Inhibition of Polo-Like Kinase 1 by BI2536 Reverses the Multidrug Resistance of Human Hepatoma Cells In Vitro and In Vivo.
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Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions.
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Inhibition of polo-like kinase 1 induces cell cycle arrest and sensitizes glioblastoma cells to ionizing radiation.
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Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer.
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Inhibition of protein kinase CK2 expression and activity blocks tumor cell growth.
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Inhibition of protein kinase CK2 suppresses tumor necrosis factor (TNF)-?-induced leukocyte-endothelial cell interaction.
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Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity.
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Inhibition of protein kinase R protects against palmitic acid-induced inflammation, oxidative stress, and apoptosis through the JNK/NF-kB/NLRP3 pathway in cultured H9C2 cardiomyocytes.
Neoplasms
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer.
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Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice.
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Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.
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Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms.
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Inhibition of Snail1-DNA-PKcs Protein-Protein Interface Sensitizes Cancer Cells and Inhibits Tumor Metastasis.
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Inhibition of TBK1 reduces choroidal neovascularization in vitro and in vivo.
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Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.
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Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3.
Neoplasms
Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells.
Neoplasms
Inhibition of TNF-alpha-induced cyclooxygenase-2 expression by Mycobacterium bovis BCG in human alveolar epithelial A549 cells.
Neoplasms
Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase.
Neoplasms
Inhibition of tumor invasiveness by 1alpha,25-dihydroxyvitamin D3 coupled to a decline in protein kinase A activity and an increase in cytoskeletal organization.
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Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing.
Neoplasms
Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context.
Neoplasms
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
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Inhibitory effect of statins on inflammation-related pathways in human abdominal aortic aneurysm tissue.
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Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice.
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Inhibitory effects of compound DMBT on hypoxia-induced vasculogenic mimicry in human breast cancer.
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Insight into conformational change for 14-3-3? protein by molecular dynamics simulation.
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Insight into the structural mechanism for PKB? allosteric inhibition by molecular dynamics simulations and free energy calculations.
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Insights from Pim1 structure for anti-cancer drug design.
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Insights into the full-length SRPK2 structure and its hydrodynamic behavior.
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Insights into the non-mitotic functions of Aurora kinase A: more than just cell division.
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Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats.
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Insulin-like growth factor ligands, receptors, and binding proteins in cancer.
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Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma.
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Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN45.
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Integrate Omics Data and Molecular Dynamics Simulations toward Better Understanding of Human 14-3-3 Interactomes and Better Drugs for Cancer Therapy.
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Integrated analysis of whole genome exon array and array-comparative genomic hybridization in gastric and colorectal cancer cells.
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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma.
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Integrin linked kinase (ILK) expression and function in vascular smooth muscle cells.
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Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma.
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Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
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Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression.
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Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha.
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Interaction with Cyclin H/Cyclin-dependent Kinase 7 (CCNH/CDK7) Stabilizes C-terminal Binding Protein 2 (CtBP2) and Promotes Cancer Cell Migration.
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Interactive competition between homologous recombination and non-homologous end joining.
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Interactive Roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases.
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Interleukin 1 and tumor necrosis factor signal transduction mechanisms: potential targets for pharmacological control of inflammation.
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Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation.
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Interleukin-17 promotes the development of cisplatin resistance in colorectal cancer.
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Interleukin-1? Assembles a Proangiogenic Signaling Module Consisting of Caveolin-1, Tumor Necrosis Factor Receptor-Associated Factor 6, p38-Mitogen-Activated Protein Kinase (MAPK), and MAPK-Activated Protein Kinase 2 in Endothelial Cells.
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Interleukin-4 down-regulates both forms of tumor necrosis factor receptor and receptor-mediated apoptosis, NF-kappaB, AP-1, and c-Jun N-terminal kinase. Comparison with interleukin-13.
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Interplay between Mdm2 and HIPK2 in the DNA damage response.
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Interplay of microRNAs to genetic, epigenetic, copy number variations of cervical cancer related genes.
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Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells.
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Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
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Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics.
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Intervention of death-associated protein kinase 1-p53 interaction exerts the therapeutic effects against stroke.
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Intra-tumoral Immune Cell Densities are Associated with Lung Adenocarcinoma Gene Alterations.
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Intracellular protein kinase CK2 inhibition by ferulic acid-based trimodal nanodevice.
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Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor.
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Intramedullary solitary fibrous tumor of dorsal spinal cord.
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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.
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Intravenous injection of l-BMAA induces a rat model with comprehensive characteristics of amyotrophic lateral sclerosis/Parkinson-dementia complex.
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Inverse association between Bmi-1 and RKIP affecting clinical outcome of gastric cancer and revealing the potential molecular mechanisms underlying tumor metastasis and chemotherapy resistance.
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Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome.
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Inverse correlation between the metastasis suppressor RKIP and the metastasis inducer YY1: Contrasting roles in the regulation of chemo/immuno-resistance in cancer.
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Inverse relation between estrogen receptors and cyclic adenosine 3':5'-monophosphate-binding proteins in hormone-dependent mammary tumor regression due to dibutyryl cyclic adenosine 3':5'-monophosphate treatment or ovariectomy.
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Investigational Aurora A kinase inhibitor alisertib (MLN8237) as an enteric-coated tablet formulation in non-hematologic malignancies: Phase 1 dose-escalation study.
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Involvement of 14-3-3 Proteins in Regulating Tumor Progression of Hepatocellular Carcinoma.
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Involvement of glycogen synthase kinase-3beta signaling and aberrant nucleocytoplasmic localization of retinoblastoma protein in tumor promotion in a rat two-stage thyroid carcinogenesis model.
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Involvement of HIF-1 in invasion of Mum2B uveal melanoma cells.
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Involvement of HSP90 in ischemic postconditioning-induced cardioprotection by inhibition of the complement system, JNK and inflammation.
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Involvement of IRE1? signaling in the hippocampus in patients with mesial temporal lobe epilepsy.
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Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9.
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Involvement of protein kinase C and cyclic adenosine 3',5'-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells.
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Involvement of reactive oxygen species in apoptosis induced by pharmacological inhibition of protein kinase CK2.
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Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
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IRAK1 Gene Polymorphism in Rheumatoid Arthritis.
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Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat.
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IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.
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IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion.
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IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration.
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Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis.
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Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin.
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Is it possible to extract a fingerprint for early breast cancer via EEG analysis?
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Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors?
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Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
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Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin expression.
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Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes.
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Isoform-specific expression and characterization of 14-3-3 proteins in human glioma tissues discovered by stable isotope labeling with amino acids in cell culture-based proteomic analysis.
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Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues.
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Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma.
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Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.
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Isomenthone protects human dermal fibroblasts from TNF-?-induced death possibly by preventing activation of JNK and p38 MAPK.
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Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway.
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Itch E3 ubiquitin ligase regulates large tumor suppressor 1 tumor-suppressor stability.
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ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
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Jatrorrhizine inhibits mammary carcinoma cells by targeting TNIK mediated Wnt/?-catenin signalling and epithelial-mesenchymal transition (EMT).
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Jianpi Yangwei decoction promotes apoptosis and suppresses proliferation of 5-fluorouracil resistant gastric cancer cells in vitro and in vivo.
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Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1? signaling pathway.
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JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes.
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JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells.
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JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells.
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JNK signaling in cancer cell survival.
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Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.
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JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.
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JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.
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Junctional tumor suppressors interact with 14-3-3 proteins to control planar spindle alignment.
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JunD-mediated repression of GADD45? and ? regulates escape from cell death in prostate cancer.
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JunD/AP-1 Antagonizes the Induction of DAPK1 To Promote the Survival of v-Src-Transformed Cells.
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K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
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K-ras Mutation Subtypes in NSCLC and Associated Co-occuring Mutations in Other Oncogenic Pathways.
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K-ras p21 expression and activity in lung and lung tumors.
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Kaempferol acts through mitogen-activated protein kinases and protein kinase B/Akt to elicit protection in a model of neuroinflammation in BV2 microglial cells.
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Kaempferol Protects Against Cerebral Ischemia Reperfusion Injury Through Intervening Oxidative and Inflammatory Stress Induced Apoptosis.
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Kainic acid induces 14-3-3 zeta expression in distinct regions of rat brain.
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Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation.
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Keeping autophagy in cheCK1.
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Keratinocyte autophagy enables the activation of keratinocytes and fibroblasts and facilitates wound healing.
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Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation.
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Ki-ras and the characteristics of mouse lung tumors.
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Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway.
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Killing tumor cells through their surface beta(2)-microglobulin or major histocompatibility complex class I molecules.
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Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis.
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KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
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Kinomic profiling of tumour xenografts derived from patients with non-small cell lung cancer confirms their fidelity and reveals potentially actionable pathways.
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Knockdown of A-kinase anchor protein 4 inhibits proliferation of triple-negative breast cancer cells in vitro and in vivo.
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Knockdown of ALPK2 inhibits the development and progression of Ovarian Cancer.
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KNOCKDOWN OF CASEIN KINASE 1e INHIBITS CELL PROLIFERATION AND INVASION OF COLORECTAL CANCER CELLS VIA INHIBITION OF THE Wnt/?-CATENIN SIGNALING.
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Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
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Knockdown of ILK inhibits glioma development via upregulation of E-cadherin and downregulation of cyclin D1.
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Knockdown of microRNA-1323 restores sensitivity to radiation by suppression of PRKDC activity in radiation-resistant lung cancer cells.
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Knockdown of Nemo?like kinase promotes metastasis in non?small?cell lung cancer.
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Knockdown of PRKAR1A, the Gene Responsible for Carney Complex, Interferes With Differentiation in Osteoblastic Cells.
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Knockdown of Rho-associated protein kinase 1 suppresses proliferation and invasion of glioma cells.
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Knockdown of RIPK2 Inhibits Proliferation and Migration, and Induces Apoptosis via the NF-?B Signaling Pathway in Gastric Cancer.
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Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells.
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Knockdown of the inflammatory factor pentraxin-3 suppresses growth and invasion of lung adenocarcinoma through the AKT and NF-kappa B pathways.
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Knockin of mutant PIK3CA activates multiple oncogenic pathways.
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Knocking down the expression of Aurora-A gene inhibits cell proliferation and induces G2/M phase arrest in human small cell lung cancer cells.
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KRAS and BRAF mutations in serum exosomes from patients with colorectal cancer in a Chinese population.
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KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.
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Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.
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Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer.
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L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma.
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Label-free assay of protein kinase A activity and inhibition in cancer cell using electrochemically-prepared AuNP/rGO nanohybrid electrode modified with C-Kemptide.
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Label-free LC-MSe in tissue and serum reveals protein networks underlying differences between benign and malignant serous ovarian tumors.
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Lack of Association of B-type Raf Kinase V600E Mutation with High-risk Tumor Features and Adverse Outcome in Conventional and Follicular Variants of Papillary Thyroid Carcinoma.
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Lack of BRAF Activating Mutations in Prostate Adenocarcinoma: A Study of 93 Cases.
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Lack of CCAAT enhancer binding protein beta (C/EBPbeta) in uterine epithelial cells impairs estrogen-induced DNA replication, induces DNA damage response pathways, and promotes apoptosis.
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Lack of STK11 gene expression in homozygous twins with Peutz-Jeghers syndrome.
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Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms.
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Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.
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Lapatinib inhibits CIP2A/PP2A/p-Akt signaling and induces apoptosis in triple negative breast cancer cells.
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Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.
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LATS1 Regulates Mixed-Lineage Kinase 3 (MLK3) Subcellular Localization and MLK3-Mediated Invasion in Ovarian Epithelial Cells.
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LC-MS/MS Analysis of Ovarian Cancer Metastasis-Related Proteins Using a Nude Mouse Model: 14-3-3 Zeta as a Candidate Biomarker.
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Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members.
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Lentivirus-mediated knockdown of NLK inhibits small-cell lung cancer growth and metastasis.
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Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation.
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Lethal neonatal rigidity and multifocal seizure syndrome with a new mutation in BRAT1.
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Lethal weapons: DAP-kinase, autophagy and cell death DAP-kinase regulates autophagy.
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Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression.
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Lewis Acid-Facilitated Radiofluorination of MN3PU: A LRRK2 Radiotracer.
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Lifespan based pharmacokinetic-pharmacodynamic model of tumor growth inhibition by anticancer therapeutics.
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Ligand Based Pharmacophore Modeling Followed by Biological Screening Lead to Discovery of Novel PDK1 Inhibitors as Anticancer Agents.
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Ligand-based Pharmacophore Modeling; Atom-based 3D-QSAR Analysis and Molecular Docking Studies of Phosphoinositide-Dependent Kinase-1 Inhibitors.
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Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules.
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Limited Significance of Activated Akt-Mammalian Target of Rapamycin Signaling Pathway in Prostate Cancer Progression.
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LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.
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Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.
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LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase.
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LINC01433 targets miR-506-3p to promote the biological progress of nasopharyngeal carcinoma cells.
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Linking apoptosis to cancer metabolism: Another missing piece of JuNK.
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Linking ATM Promoter Methylation to Cell Cycle Protein Expression in Brain Tumor Patients: Cellular Molecular Triangle Correlation in ATM Territory.
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LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.
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Lipid peroxidation activates mitogen-activated protein kinases in testicular ischemia-reperfusion injury.
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Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.
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Lipopolysaccharide and lipoteichoic acid influence milk production ability via different early responses in bovine mammary epithelial cells.
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Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms.
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Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice.
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Lipoxin A4 attenuates radicular pain possibly by inhibiting spinal ERK, JNK and NF-?B/p65 and cytokine signals, but not p38, in a rat model of non-compressive lumbar disc herniation.
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Liquiritigenin Potentiates the Inhibitory Effects of Cisplatin on Invasion and Metastasis Via Downregulation MMP-2/9 and PI3 K/AKT Signaling Pathway in B16F10 Melanoma Cells and Mice Model.
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Lithium and Therapeutic Targeting of GSK-3.
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Lithium chloride suppresses colorectal cancer cell survival and proliferation through ROS/GSK-3?/NF-?B signaling pathway.
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Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signalling.
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Lithium inhibits carcinoid cell growth in vitro.
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Lithium ions: a novel treatment for pheochromocytomas and paragangliomas.
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Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics.
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Liver Kinase B1 Suppresses Lipopolysaccharide-induced Nuclear Factor ?B (NF-?B) Activation in Macrophages.
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Liver kinase B1/adenosine monophosphate-activated protein kinase signaling axis induces p21/WAF1 expression in a p53-dependent manner.
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Liver Protects Metastatic Prostate Cancer From Induced Death by Activating E-cadherin Signaling.
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Liver-specific ablation of krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma.
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LKB1 Catalytic Activity Contributes to Estrogen Receptor {alpha} Signaling.
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LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells.
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LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.
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LKB1 deficiency promotes proliferation and invasion of glioblastoma through activation of mTOR and focal adhesion kinase signaling pathways.
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LKB1 deletion with the RIP.Cre-transgene modifies pancreatic {beta}-cell morphology and enhances insulin secretion in vivo.
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LKB1 downregulation may be independent of promoter methylation or FOXO3 expression in head and neck cancer.
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LKB1 expression is inhibited by estradiol-17? in MCF-7 cells.
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LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor.
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LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.
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Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis.
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LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.
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LKB1 kinase: master and commander of metabolism and polarity.
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LKB1 loss cooperating with BRAF V600E promotes melanoma cell invasion and migration by up-regulation MMP-2 via PI3K/Akt/mTOR pathway.
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LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.
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LKB1 loss of function studied in vivo.
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LKB1 modulates lung cancer differentiation and metastasis.
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LKB1 preserves genome integrity by stimulating BRCA1 expression.
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LKB1 reduces ROS-mediated cell damage via activation of p38.
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LKB1 regulated pathways in lung cancer invasion and metastasis.
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LKB1 regulates TCR-mediated PLC?1 activation and thymocyte positive selection.
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LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate.
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LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain.
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LKB1 tumor suppressor protein: PARtaker in cell polarity.
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LKB1 up-regulation inhibits hypothalamic inflammation and attenuates diet-induced obesity in mice.
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LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
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LKB1, a protein kinase regulating cell proliferation and polarity.
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LKB1, the multitasking tumour suppressor kinase.
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LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.
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LKB1: cancer, polarity, metabolism, and now fertility.
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Lnc-MUC20-9 binds to ROCK1 and functions as a tumor suppressor in bladder cancer.
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LncRNA EGFR-AS1 Upregulates ROCK1 by Sponging miR-145 to Promote Esophageal Squamous Cell Carcinoma Cell Invasion and Migration.
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lncRNA HAND2-AS1 inhibits cancer cell proliferation, migration and invasion by downregulating ROCK1 in HPV-positive and negative cervical squamous cell carcinoma.
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LncRNA HAND2-AS1 overexpression inhibits cancer cell proliferation in melanoma by downregulating ROCK1.
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LncRNA LINK-A regulates ROCK1 expression in early-stage pancreatic adenocarcinoma.
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lncRNA MALAT1 Accelerates Skeletal Muscle Cell Apoptosis and Inflammatory Response in Sepsis by Decreasing BRCA1 Expression by Recruiting EZH2.
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LncRNA MCM3AP-AS1 sponges miR-148a to enhance cell invasion and migration in small cell lung cancer.
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LncRNA NEAT1 Acts as an miR-148b-3p Sponge to Regulate ROCK1 Inhibition of Retinoblastoma Growth.
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LncRNA NEAT1 regulates cervical carcinoma proliferation and invasion by targeting AKT/PI3K.
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lncRNA TINCR sponges miR-214-5p to upregulate ROCK1 in hepatocellular carcinoma.
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LncRNA XIST regulates cell proliferation, migration and invasion of glioblastoma via regulating miR-448 and ROCK1.
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lncRNA-CCHE1 is involved in migration and invasion but not in proliferation of pancreatic adenocarcinoma cells possibly by interacting with ROCK1.
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LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells.
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LncRNA-zinc finger protein 281 downregulates rho-associated coiled-coil containing protein kinase 1 by upregulating miR-144 in osteosarcoma.
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Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.
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Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
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Localization of the adenomatous polyposis coli tumour suppressor protein in the mouse central nervous system.
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Long non-coding RNA CCHE1 participates in postoperative distant recurrence but not local recurrence of osteosarcoma possibly by interacting with ROCK1.
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Long non-coding RNA HOXA11-AS functions as a competing endogenous RNA to regulate ROCK1 expression by sponging miR-124-3p in osteosarcoma.
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Long Noncoding RNA HOTAIR Contributes to Progression in Hepatocellular Carcinoma by Sponging miR-217-5p.
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Long noncoding RNA MORT overexpression inhibits cancer cell proliferation in oral squamous cell carcinoma by downregulating ROCK1.
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Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment-related genes.
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Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho-associated protein kinase 1.
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Long noncoding RNA-JPX predicts the poor prognosis of ovarian cancer patients and promotes tumor cell proliferation, invasion and migration by the PI3K/Akt/mTOR signaling pathway.
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Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death.
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Long-term administration of melatonin attenuates neuroinflammation in the aged mouse brain.
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Long-wave ultraviolet radiation induces protein kinase C in normal human keratinocytes.
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Loss of 14-3-3 sigma protein expression and presence of human papillomavirus type 16 E6 in oral squamous cell carcinoma.
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Loss of 4.1N in epithelial ovarian cancer results in EMT and matrix-detached cell death resistance.
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Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila.
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Loss of cellular identity in common pre-clinical models of serine?threonine kinase 11 (Liver kinase B1) loss.
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Loss of CHEK2 Predicts Progression in Stage pT1 Non-Muscle-Invasive Bladder Cancer (NMIBC).
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Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers.
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Loss of endogenous interleukin-12 activates survival signals in ultraviolet-exposed mouse skin and skin tumors.
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Loss of heterozygosity on the short arm of chromosome 3 in nasopharyngeal carcinoma.
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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice.
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Loss of LKB1 and p53 synergizes to alter fallopian tube epithelial phenotype and high-grade serous tumorigenesis.
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Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53.
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Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
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Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations.
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Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism.
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Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis.
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Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
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Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.
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Loss of PTEN expression leading to high Akt activation in human multiple myelomas.
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Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors.
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Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations.
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Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis.
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Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC).
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Loss of Raf-1 kinase inhibitor protein expression is associated with lymph node metastasis in papillary thyroid cancer.
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Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer.
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Loss of Raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma.
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Loss of RKIP expression during the carcinogenic evolution of endometrial cancer.
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Loss of RKIP expression is associated with poor survival in GISTs.
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Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis.
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Loss of SNAIL inhibits cellular growth and metabolism through the miR-128-mediated RPS6KB1/HIF-1?/PKM2 signaling pathway in prostate cancer cells.
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Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.
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Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms.
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Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
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Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers.
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Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin.
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Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1?.
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Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis.
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Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer.
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Low RKIP expression associates with poor prognosis in bladder cancer patients.
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Low STYK1 expression indicates poor prognosis in gastric cancer.
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Low-level arsenic causes chronic inflammation and suppresses expression of phagocytic receptors.
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LRRK2 and autophagy: a common pathway for disease.
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LRRK2 and human disease: a complicated question or a question of complexes?
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LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease.
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LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.
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LRRK2 is a candidate prognostic biomarker for clear cell renal cell carcinoma.
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LRRK2 Is Associated with Recurrence-Free Survival in Intrahepatic Cholangiocarcinoma and Downregulation of LRRK2 Suppresses Tumor Progress In Vitro.
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LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Neoplasms
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.
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LRRK2 Regulates CPT1A to Promote ?-Oxidation in HepG2 Cells.
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LRRK2 signaling pathways: the key to unlocking neurodegeneration?
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Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism.
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Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways.
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Luteolin, a Novel Natural Inhibitor of Tumor Progression Locus 2 Serine/Threonine Kinase, Inhibits Tumor Necrosis Factor-{alpha}-Induced Cyclooxygenase-2 Expression in JB6 Mouse Epidermis Cells.
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Lycorine Induces Mitochondria-Dependent Apoptosis in Hepatoblastoma HepG2 Cells Through ROCK1 Activation.
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Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis.
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Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation.
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Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.
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Lysophosphatidic acid-RAGE axis promotes lung and mammary oncogenesis via protein kinase B and regulating tumor microenvironment.
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Lysozyme-Antimicrobial Peptide Fusion Protein Promotes the Diabetic Wound Size Reduction in Streptozotocin (STZ)-Induced Diabetic Rats.
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M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.
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m-TOR inhibitors: biology and use in the treatment of haematological diseases.
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Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells.
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Macrophage depletion by clodronate attenuates bone morphogenetic protein-7 induced M2 macrophage differentiation and improved systolic blood velocity in atherosclerosis.
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Macrophage Depletion Improves Endothelial Insulin Resistance and Protects against Cardiovascular Injury in Salt-Sensitive Hypertension.
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Macrophage Liver Kinase B1 Inhibits Foam Cell Formation and Atherosclerosis.
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Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D(3).
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Macrophage-Derived IL1? and TNF? Regulate Arginine Metabolism in Neuroblastoma.
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Maintaining glycogen synthase kinase-3 activity is critical for mTOR kinase inhibitors to inhibit cancer cell growth.
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Malignant tumors associated with Peutz-Jeghers syndrome: Five cases from a single surgical unit.
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Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.
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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
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Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/?WAPCre mouse model.
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation.
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MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway.
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MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1.
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MAP4K4 controlled integrin ?1 activation and c-Met endocytosis are associated with invasive behavior of medulloblastoma cells.
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MAPK signalling in rheumatoid joint destruction: can we unravel the puzzle?
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MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
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Marine lipopeptide Iturin A inhibits Akt mediated GSK3? and FoxO3a signaling and triggers apoptosis in breast cancer.
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Mass balance, routes of excretion, and pharmacokinetics of investigational oral [14C]-alisertib (MLN8237), an Aurora A kinase inhibitor in patients with advanced solid tumors.
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation.
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MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.
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Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer.
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MASTL: A novel therapeutic target for Cancer Malignancy.
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Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers.
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Maternal periodontitis decreases plasma membrane GLUT4 content in skeletal muscle of adult offspring.
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Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.
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Maxillary sinus melanoma as the presenting feature of Carney complex.
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MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells.
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mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer.
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Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells.
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mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer.
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Mechanism and efficacy of sub-50-nm tenfibgen nanocapsules for cancer cell-directed delivery of anti-CK2 RNAi to primary and metastatic squamous cell carcinoma.
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Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
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Mechanism of Hepatitis C Virus-Induced Diabetes Mellitus.
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Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer.
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Mechanisms of apoptosis by the tumor suppressor Par-4.
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Mechanisms of hypertension associated with BAY 43-9006.
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Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells.
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Mechanisms of Tumor Regression and Resistance to Estrogen Deprivation and Fulvestrant in a Model of Estrogen Receptor-Positive, HER-2/neu-Positive Breast Cancer.
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Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia.
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Mechanistic insights and perspectives involved in neuroprotective action of quercetin.
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Mechanistic insights into the urea-induced denaturation of kinase domain of human integrin linked kinase.
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MED27 promotes melanoma growth by targeting AKT/MAPK and NF-?B/iNOS signaling pathways.
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Medicinal Chemistry and Pharmacology Focused on Cannabidiol, a Major Component of the Fiber-Type Cannabis.
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Medicinal Plants in the Prevention and Treatment of Colon Cancer.
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Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib.
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Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1.
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MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease.
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MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer.
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MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.
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MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals.
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Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations.
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Melanotic nonpsammomatous trigeminal schwannoma as the first manifestation of Carney complex: case report.
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MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.
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Membrane Androgen Receptor ZIP9 Induces Croaker Ovarian Cell Apoptosis via Stimulatory G Protein Alpha Subunit and MAP Kinase Signaling.
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Membrane localization of TRAF 3 enables JNK activation.
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Membrane type 1-matrix metalloproteinase/Akt signaling axis modulates TNF-?-induced procoagulant activity and apoptosis in endothelial cells.
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Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.
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Menin promotes the Wnt signaling pathway in pancreatic endocrine cells.
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Meridianins and Lignarenone B as Potential GSK3? Inhibitors and Inductors of Structural Neuronal Plasticity.
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Mesenchymal stem cell therapy inhibited inflammatory and profibrotic pathways induced by partial bladder outlet obstruction and prevented high-pressure urine storage.
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Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.
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Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK.
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Metabolic Modulation of the Tumor Microenvironment Leads to Multiple Checkpoint Inhibition and Immune Cell Infiltration.
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Metabolic regulation and relationship of endogenous protein kinase activity and steroidogenesis in isolated adrenocortical carcinoma cells of the rat.
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Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy.
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Metastasis suppressor microRNA-335 targets the formin family of actin nucleators.
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Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
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Metastasis-associated gene 1 (MTA1) enhances cisplatin resistance of malignant pleural mesothelioma by ATR-Chk1-mediated DNA repair.
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Metastasis-associated protein 2 promotes the metastasis of non-small cell lung carcinoma by regulating the ERK/AKT and VEGF signaling pathways.
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Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.
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Methods to study cancer therapeutic drugs that target cell cycle checkpoints.
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Methylation and intratumoural heterogeneity of 14-3-3 sigma in oral cancer.
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Methylation of CALCA and CALCB in Pancreatic Ductal Adenocarcinoma.
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Methylation of STK11 promoter is a risk factor for tumor stage and survival in clear cell renal cell carcinoma.
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Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
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Methylation status of genes in papillary thyroid carcinoma.
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Methyleugenol and selected oxidative metabolites affect DNA-Damage signalling pathways and induce apoptosis in human colon tumour HT29 cells.
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Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin.
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mi-R4435-2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2.
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Micropillar arrays as potential drug screens: Inhibition of micropillar-mediated activation of the FAK-Src-paxillin signaling pathway by the CK2 inhibitor CX-4945.
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MicroRNA let-7i-3p affects osteoblast differentiation in ankylosing spondylitis via targeting PDK1.
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MicroRNA regulation of growth factor receptor signaling in human cancer cells.
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MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling.
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MicroRNA-101 inhibits proliferation, migration and invasion in osteosarcoma cells by targeting ROCK1.
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MicroRNA-124 (MiR-124) Inhibits Cell Proliferation, Metastasis and Invasion in Colorectal Cancer by Downregulating Rho-Associated Protein Kinase 1(ROCK1).
Neoplasms
MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma.
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MicroRNA-1280 inhibits invasion and metastasis by targeting ROCK1 in bladder cancer.
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MicroRNA-137 inhibits tumor growth and sensitizes chemosensitivity to paclitaxel and cisplatin in lung cancer.
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MicroRNA-137-regulated AKT serine/threonine kinase 2 inhibits tumor growth and sensitizes cisplatin in patients with non-small cell lung cancer.
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microRNA-138-5p as a Worse Prognosis Biomarker in Pediatric, Adolescent, and Young Adult Osteosarcoma.
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MicroRNA-140-5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21-activated kinase 4.
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MicroRNA-144 acts as a tumor suppressor by targeting Rho-associated coiled-coil containing protein kinase 1 in osteosarcoma cells.
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MicroRNA-145 inhibits growth and migration of breast cancer cells through targeting oncoprotein ROCK1.
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microRNA-145 inhibits osteosarcoma cell proliferation and invasion by targeting ROCK1.
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MicroRNA-148a Acts As a Tumor Suppressor in Osteosarcoma Via Targeting Rho-Associated Coiled-Coil Kinase.
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MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer.
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MicroRNA-150 targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in papillary thyroid carcinoma.
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MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression.
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MicroRNA-21 Overexpression Contributes to Vestibular Schwannoma Cell Proliferation and Survival.
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MicroRNA-215 acts as a tumor suppressor in breast cancer by targeting AKT serine/threonine kinase 1.
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MicroRNA-217 functions as a tumor suppressor in cervical cancer cells through targeting Rho-associated protein kinase 1.
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MicroRNA-223 Enhances Radiation Sensitivity of U87MG Cells In Vitro and In Vivo by Targeting Ataxia Telangiectasia Mutated.
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MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells.
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MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines.
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MicroRNA-300 inhibited glioblastoma progression through ROCK1.
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MicroRNA-335 and its target Rock1 synergistically influence tumor progression and prognosis in osteosarcoma.
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MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway.
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MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1.
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MicroRNA-433 inhibits cell proliferation in hepatocellular carcinoma by targeting p21 activated kinase (PAK4).
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MicroRNA-466 inhibits cancer cell migration and invasion in hepatocellular carcinoma by indirectly mediating the downregulation of ROCK2.
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MicroRNA-497 Accelerates Apoptosis While Inhibiting Proliferation, Migration, and Invasion through negative regulation of the MAPK/ERK signaling pathway via RAF-1.
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MicroRNA-497 acts as a tumor suppressor in gastric cancer and is downregulated by DNA methylation.
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MicroRNA-584-3p, a novel tumor suppressor and prognostic marker, reduces the migration and invasion of human glioma cells by targeting hypoxia-induced ROCK1.
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MicroRNA-625-3p promotes the proliferation, migration and invasion of thyroid cancer cells by up-regulating astrocyte elevated gene 1.
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MicroRNA?122 downregulates Rho?associated protein kinase 2 expression and inhibits the proliferation of prostate carcinoma cells.
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MicroRNA?144 inhibits migration and proliferation in rectal cancer by downregulating ROCK?1.
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MicroRNA?448 inhibits the progression of retinoblastoma by directly targeting ROCK1 and regulating PI3K/AKT signalling pathway.
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MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma.
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Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7.
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MIF family proteins in genitourinary cancer: tumorigenic roles and therapeutic potential.
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Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma.
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Mining CK2 in cancer.
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MIP-1? induces inflammatory responses by upregulating chemokine receptor 1/chemokine receptor 5 and activating c-Jun N-terminal kinase and mitogen-activated protein kinase signaling pathways in acute pancreatitis.
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MiR-103 regulates hepatocellular carcinoma growth by targeting AKAP12.
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miR-124 inhibits growth and invasion of gastric cancer by targeting ROCK1.
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MiR-137's tumor suppression on prolactinomas by targeting MITF and modulating Wnt signaling pathway.
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Mir-138-5p acts as a tumor suppressor by targeting pyruvate dehydrogenase kinase 1 in human retinoblastoma.
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miR-139 inhibits osteosarcoma cell proliferation and invasion by targeting ROCK1.
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MiR-139 prompts the development of osteosarcomas mainly through targeting ROCK1.
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MiR-139-5p/SLC7A11 inhibits the proliferation, invasion and metastasis of pancreatic carcinoma via PI3K/Akt signaling pathway.
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miR-141-3p promotes proliferation and metastasis of nasopharyngeal carcinoma by targeting NME1.
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MiR-142-3p targeting NUCKS1 inhibits proliferation and invasion of pancreatic cancer cells.
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MiR-144 Inhibits Tumor Growth and Metastasis in Osteosarcoma via dual-suppressing RhoA/ROCK1 Signaling Pathway.
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miR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1.
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MiR-145 suppresses cell proliferation and motility by inhibiting ROCK1 in hepatocellular carcinoma.
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miR-150 is downregulated in osteosarcoma and suppresses cell proliferation, migration and invasion by targeting ROCK1.
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MiR-155 is a liposarcoma oncogene that targets casein kinase-1? and enhances ?-catenin signaling.
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MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells.
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miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase.
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MiR-199a targeting ROCK1 to affect kidney cell proliferation, invasion and apoptosis.
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MiR-200b Inhibits Tumor Growth and Chemoresistance via Targeting p70S6K1 in Lung Cancer.
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miR-200c dampens cancer cell migration via regulation of protein kinase A subunits.
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MiR-200c inhibits proliferation and promotes apoptosis of Wilms tumor cells by regulating akt signaling pathway.
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miR-214-5p Targets ROCK1 and Suppresses Proliferation and Invasion of Human Osteosarcoma Cells.
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miR-30a can inhibit DNA replication by targeting RPA1 thus slowing cancer cell proliferation.
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MiR-30a-5p confers cisplatin resistance by regulating IGF1R expression in melanoma cells.
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miR-31-5p Regulates 14-3-3 ? to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway.
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MiR-335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma.
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miR-335 Acts as a Tumor Suppressor and Enhances Ionizing Radiation-Induced Tumor Regression by Targeting ROCK1.
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miR-335 suppresses migration and invasion by targeting ROCK1 in osteosarcoma cells.
Neoplasms
miR-497 inhibits the carcinogenesis of hepatocellular carcinoma by targeting the Rictor/Akt signal pathway.
Neoplasms
MiR-506 suppresses cell proliferation and tumor growth by targeting Rho-associated protein kinase 1 in hepatocellular carcinoma.
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miR-584 Suppresses Invasion and Cell Migration of Thyroid Carcinoma by Regulating the Target Oncogene ROCK1.
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MiR-592 functions as a tumor suppressor in acute myeloid leukemia by targeting ROCK1 and predicts patients' prognosis.
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MiR-9-5p Inhibits the Proliferation, Migration and Invasion of Choroidal Melanoma by Targeting BRAF.
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miR-96 exerts carcinogenic effect by activating AKT/GSK-3?/?-catenin signaling pathway through targeting inhibition of FOXO1 in hepatocellular carcinoma.
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miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1.
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Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.
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Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas.
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Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells.
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miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression.
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Misshapen Disruption Cooperates with RasV12 to Drive Tumorigenesis.
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Mitochondrial A-kinase anchoring protein 121 binds type II protein kinase A and enhances steroidogenic acute regulatory protein-mediated steroidogenesis in MA-10 mouse leydig tumor cells.
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Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2.
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Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis.
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Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation.
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Mitochondrial control by DRP1 in brain tumor initiating cells.
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Mitochondrial dysfunction in ataxia-telangiectasia.
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Mitogen-activated protein kinase pathway in osteosarcoma.
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Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells.
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Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.
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Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor-induced interleukin-6 expression via human antigen R.
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Mitogen-Activated Protein Kinases Are Activated in Placental Injury in Rat Model of Acute Pancreatitis in Pregnancy.
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Mitotic Failures in Cancer: Aurora B Kinase and its Potential Role in the Development of Aneuploidy.
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Mitotic kinases as drivers of the epithelial-to-mesenchymal transition and as therapeutic targets against breast cancers.
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MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.
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MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells.
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MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth.
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MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.
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MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas.
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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.
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MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.
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MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
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MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression.
Neoplasms
Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila.
Neoplasms
Modeling human disease in yeast: recreating the PI3K-PTEN-Akt signaling pathway in Saccharomyces cerevisiae.
Neoplasms
Modification of TAK1 by O-linked N-acetylglucosamine facilitates TAK1 activation and promotes M1 macrophage polarization.
Neoplasms
Modified lingguizhugan decoction incorporated with dietary restriction and exercise ameliorates hyperglycemia, hyperlipidemia and hypertension in a rat model of the metabolic syndrome.
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Modified protein kinase activity and isozyme distribution in adenocarcinoma of the human colon.
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Modulating Polo-Like Kinase 1 as a Means for Cancer Chemoprevention.
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Modulating Tumor Microenvironment: A Review on STK11 Immune Properties and Predictive vs Prognostic Role for Non-small-cell Lung Cancer Immunotherapy.
Neoplasms
Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappaB signaling.
Neoplasms
Modulation of autophagy in exJSRV-env-transfected cells through the Akt/mTOR and MAPK signaling pathway.
Neoplasms
Modulation of CASC2/miR-21/PTEN pathway sensitizes cervical cancer to cisplatin.
Neoplasms
Modulation of insulin effects on phosphorylation of protein kinase B and glycogen synthesis by tumor necrosis factor-alpha in HepG2 cells.
Neoplasms
Modulation of signal-transduction pathways by chemopreventive agents.
Neoplasms
Modulation of the human protein kinase C alpha gene promoter by activator protein-2.
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Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein.
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Modulation of tumor fatty acids, through overexpression or loss of Thyroid Hormone Responsive Protein Spot 14, is associated with altered growth and metastasis.
Neoplasms
Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.
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Molecular alterations in apoptotic pathways after PKB/Akt-mediated chemoresistance in NCI H460 cells.
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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas.
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Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.
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Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.
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Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas.
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Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis.
Neoplasms
Molecular characteristics of immunogenic cancer cell death.
Neoplasms
Molecular classification of non-muscle-invasive bladder cancer (pTa low-grade, pT1 low-grade, and pT1 high-grade subgroups) using methylation of tumor-suppressor genes.
Neoplasms
Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway.
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Molecular cloning and expression analysis of TRAF3 in chicken.
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Molecular cloning and functional characterization of zebrafish ATM.
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Molecular cloning, polymorphism, and expression analysis of the LKB1/STK11 gene and its association with non-specific digestive disorder in rabbits.
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Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
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Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy.
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Molecular dissection of large cell carcinomas of the lung with null immunophenotype.
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Molecular Dynamics Guided Receptor Independent 4D QSAR Studies of Substituted Coumarins as Anticancer Agents.
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Molecular genetic advances in pituitary tumor development.
Neoplasms
Molecular imaging of glycogen synthase kinase-3beta and casein kinase-1alpha kinases.
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Molecular insights into Peutz-Jeghers syndrome: two probands with a germline mutation of LKB1.
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Molecular mechanism of hepatitis B virus (HBV) on suppression of raf kinase inhibitor protein (RKIP) expression.
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Molecular mechanism of LKB1 in the invasion and metastasis of colorectal cancer.
Neoplasms
Molecular mechanisms underlying anticancer effects of myricetin.
Neoplasms
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Neoplasms
Molecular pathways: Beta-adrenergic signaling in cancer.
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Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells.
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Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy.
Neoplasms
Molecular Pathways: Revisiting Glycogen Synthase Kinase-3? as a Target for the Treatment of Cancer.
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Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers.
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Molecular signal networks and regulating mechanisms of the unfolded protein response.
Neoplasms
Molecular targeting for treatment of advanced hepatocellular carcinoma.
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Molecular Targeting of ERKs/RSK2 signaling in cancers.
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Molecular targets and abdominal aortic aneurysms.
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Molecular targets of curcumin in breast cancer (Review).
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Molecular Testing Identifies Determinants of Exceptional Response and Guides Precision Therapy in a Patient with Lethal, Treatment-emergent Neuroendocrine Prostate Cancer.
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Moloney murine leukemia virus infection accelerates lymphomagenesis in E mu-bcl-2 transgenic mice.
Neoplasms
Monitoring 14-3-3 protein interactions with a homogeneous fluorescence polarization assay.
Neoplasms
Monitoring and signaling of radiation-induced damage in mammalian cells.
Neoplasms
Monitoring antitumor efficacy of rapamycin in Kaposi sarcoma.
Neoplasms
Monitoring the response of urothelial precancerous lesions to Bacillus Calmette-Guerin at the proteome level in an in vivo rat model.
Neoplasms
Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance.
Neoplasms
Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways.
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Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?
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Mps1 is associated with the BRAFV600E mutation but does not rely on the classic RAS/RAF/MEK/ERK signaling pathway in thyroid carcinoma.
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mRNA expression of programmed cell death ligand 1 and components of the phosphatidylinositol 3-kinase/AKT/phosphatase and tensin homolog pathway in epidermal growth factor receptor mutation-positive lung adenocarcinoma.
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MSK1 promotes cell proliferation and metastasis in uveal melanoma by phosphorylating CREB.
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MSK2 promotes proliferation and tumor formation in squamous cervical cancer via PAX8/RB-E2F1/cyclin A2 axis.
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Mst-1 deficiency promotes post-traumatic spinal motor neuron survival via enhancement of autophagy flux.
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MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.
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MST1 Negatively Regulates TNF?-Induced NF-?B Signaling through Modulating LUBAC Activity.
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Mst1 regulates glioma cell proliferation via the AKT/mTOR signaling pathway.
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MST4 Regulates Epithelial-Mesenchymal Transition of Choriocarcinoma by Mediating TGF-?1 Expression.
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mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.
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mTOR coordinates protein synthesis, mitochondrial activity and proliferation.
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mTOR expression and prognosis in elderly patients with laryngeal carcinoma: Uni- and multivariate analyses.
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mTOR in renal cell cancer: modulator of tumor biology and therapeutic target.
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MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma.
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mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.
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mTOR Regulation of Metabolism in Hematologic Malignancies.
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mTOR-Rictor-EGFR axis in oncogenesis and diagnosis of glioblastoma multiforme.
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mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition.
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MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells.
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Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.
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Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases.
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Multiple primary malignant neoplasms: A case report and literature review.
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Multiple squamous cell carcinomas of the skin after therapy with sorafenib combined with tipifarnib.
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Multistage Vectored siRNA Targeting Ataxia-Telangiectasia Mutated for Breast Cancer Therapy.
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Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors.
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Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication.
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Murine Prkdc Polymorphisms Impact DNA-PKcs Function.
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Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.
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Mutant B-RAF mediates resistance to anoikis via Bad and Bim.
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Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.
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Mutant K-Ras increases GSK-3? gene expression via an ETS-p300 transcriptional complex in pancreatic cancer.
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Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.
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Mutated mitogen-activated protein kinase: a tumor rejection antigen of mouse sarcoma.
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Mutation analysis of multiple pilomatricomas in a patient with myotonic dystrophy type 1 suggests a DM1-associated hypermutation phenotype.
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Mutation Analysis of PRKAR1A Gene in a Patient with Atrial Myxoma.
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Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas.
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Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck.
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Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53.
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Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A.
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Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53.
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Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.
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Mutational analysis of the BRAF gene in human tumor cells.
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Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance.
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Mutations and aberrant transcriptions of stk11 (lkb1) gene in rat liver tumors.
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Mutations in Critical Domains Confer the Human mTOR Gene Strong Tumorigenicity.
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Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
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Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
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Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.
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Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
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Mutations of the BRAF gene in human cancer.
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Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas" (Carney complex).
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Mutations of the PH domain of protein kinase B (PKB/AKT) are absent in human epidermal skin tumors.
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Mutations of the STK11 gene in sporadic gastric carcinoma.
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Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer.
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Mutual regulation between DNA-PKcs and snail1 leads to increased genomic instability and aggressive tumor characteristics.
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MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.
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MYC is expressed in the stromal and epithelial cells of primary breast carcinoma and paired nodal metastases.
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MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.
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Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
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Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/?-catenin signaling.
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Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance.
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Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody.
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N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.
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N-substituted azaindoles as potent inhibitors of Cdc7 kinase.
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N6-Isopentenyladenosine promoted HeLa cell apoptosis through inhibitions of AKT and transforming growth factor ?-activated kinase 1 activation.
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NAD(P)H Quinone Dehydrogenase 1 Ablation Inhibits Activation of the Phosphoinositide 3-Kinase/Akt Serine/Threonine Kinase and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathways and Blocks Metabolic Adaptation in Hepatocellular Carcinoma.
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NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.
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NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.
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Nano Chromium Picolinate Improves Gene Expression Associated with Insulin Signaling in Porcine Skeletal Muscle and Adipose Tissue.
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Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells.
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Nanolock-Nanopore Facilitated Digital Diagnostics of Cancer Driver Mutation in Tumor Tissue.
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Nanomediator-Effector Cascade Systems for Amplified Protein Kinase Activity Imaging and Phosphorylation-Induced Drug Release In Vivo.
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Nanotube-based colorimetric probe for ultrasensitive detection of ataxia telangiectasia mutated protein.
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Natural and synthetic bioactive inhibitors of glycogen synthase kinase.
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Natural Dietary Supplement, Carvacrol, Alleviates LPS-Induced Oxidative Stress, Neurodegeneration, and Depressive-Like Behaviors via the Nrf2/HO-1 Pathway.
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Natural zeolite clinoptilolite: new adjuvant in anticancer therapy.
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Naturally occurring reoviruses for human cancer therapy.
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NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.
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Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells.
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Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.
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Negative pressure wound therapy promoted wound healing by suppressing inflammation via down-regulating MAPK-JNK signaling pathway in diabetic foot patients.
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Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression.
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Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer.
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Nek2 is a novel regulator of B cell development and immunological response.
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NEK2 Promotes Cell Proliferation and Glycolysis by Regulating PKM2 Abundance via Phosphorylation in Diffuse Large B-Cell Lymphoma.
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Nemo-like kinase (NLK) inhibits the progression of NSCLC via negatively modulating Wnt signaling pathway.
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Nemo?like kinase expression predicts poor survival in colorectal cancer.
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Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression.
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Network Pharmacology Analysis of Traditional Chinese Medicine Formula Shuang Di Shou Zhen Tablets Treating Nonexudative Age-Related Macular Degeneration.
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Network Pharmacology Analysis of Traditional Chinese Medicine Formula Xiao Ke Yin Shui Treating Type 2 Diabetes Mellitus.
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Network pharmacology-based strategy to investigate pharmacological mechanisms of Tinospora sinensis for treatment of Alzheimer's disease.
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Network Pharmacology-Based Study on the Mechanism of Bushen-Jianpi Decoction in Liver Cancer Treatment.
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Neural Precursor Cycling at Sonic Speed: N-Myc Pedals, GSK-3 Brakes.
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Neuregulin and laminin stimulate phosphorylation of the NF2 tumor suppressor in Schwann cells by distinct protein kinase A and p21-activated kinase-dependent pathways.
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Neurobeachin (NBEA) is a target of recurrent interstitial deletions at 13q13 in patients with MGUS and multiple myeloma.
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Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.
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Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers.
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Neuroendocrine Modulation of Signal Transducer and Activator of Transcription-3 in Ovarian Cancer.
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Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion.
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Neuroprotective effects of Activin A on endoplasmic reticulum stress-mediated apoptotic and autophagic PC12 cell death.
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Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor.
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New anticancer agents and therapeutic strategies in development for solid cancers: a clinical perspective.
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New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.
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New genetic variants of LATS1 detected in urinary bladder and colon cancer.
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New germline BRCA2 gene variant in the Tuvinian Mongol breast cancer patients.
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New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response.
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New insights into RSK activation and hematopoietic cancer.
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New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
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New Insights into the Molecular Characteristics of Pulmonary Carcinoids and Large Cell Neuroendocrine Carcinomas, and the Impact on Their Clinical Management.
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New leads for selective GSK-3 inhibition: pharmacophore mapping and virtual screening studies.
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New lung cancer panel for high-throughput targeted resequencing.
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New perspective on the dual functions of indirubins in cancer therapy and neuroprotection.
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New perspectives for targeting RAF kinase in human cancer.
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New Players in the Regulation of DNA-PK Activity: Survivin Joins the Crowd.
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New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.
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New protein kinase CK2 inhibitors: jumping out of the catalytic box.
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New Pyrazolopyrimidine Inhibitors of Protein Kinase D as Potent Anticancer Agents for Prostate Cancer Cells.
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New RAF kinase inhibitors in cancer therapy.
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New Strategies to Direct Therapeutic Targeting of PML to Treat Cancers.
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New type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A.
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Next-Generation Sequencing Approach to Non-Small Cell Lung Carcinoma Yields More Actionable Alterations.
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NF-?B Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance.
Neoplasms
NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases.
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NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival.
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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.
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NF-kappaB in cancer--a friend turned foe.
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NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death.
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NF-kappaB signal triggering and termination by tumor necrosis factor receptor 2.
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NF?B-Associated Pathways in Progression of Chemoresistance to 5-Fluorouracil in an In Vitro Model of Colonic Carcinoma.
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NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma.
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Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways.
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Nifuroxazide attenuates experimentally-induced hepatic encephalopathy and the associated hyperammonemia and cJNK/caspase-8/TRAIL activation in rats.
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Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3? in a hamster model of oral oncogenesis.
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Nitidine chloride inhibits the appearance of cancer stem-like properties and regulates potential the mitochondrial membrane alterations of colon cancer cells.
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Nitrogen Permease Regulator-Like-2 Exhibited Anti-Tumor Effects And Enhanced The Sensitivity Of Colorectal Cancer Cells To Oxaliplatin And 5-Fluorouracil.
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NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells.
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Nm23-H1 is involved in the repair of ionizing radiation-induced DNA double-strand breaks in the A549 lung cancer cell line.
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NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.
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NMDA receptors on the surface of cancer cells: target for chemotherapy?
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NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate.
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No Association between Promoter Polymorphism of STK11 Gene and Lung Cancer Risk in the Korean Population.
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No evidence of oncogenic KRAS mutations in squamous cell carcinomas of the anogenital tract and head and neck region independent of human papillomavirus and p16(INK4a) status.
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No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.
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No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer.
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Nodal increases the malignancy of childhood neuroblastoma cells via regulation of Zeb1.
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Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression.
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Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism.
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Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX.
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Non-canonical Raf-1/p70S6K signalling in non-small-cell lung cancer.
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Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.
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Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model.
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Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.
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Non-redundant activity of GSK-3? and GSK-3? in T cell-mediated tumor rejection.
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Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer.
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Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
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Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia.
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NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.
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Novel 18F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3?.
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Novel and Recurrent Mutations of STK11 Gene in Six Chinese Cases with Peutz-Jeghers Syndrome.
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Novel Anti-Angiogenic and Anti-Tumour Activities of the N-Terminal Domain of NOEY2 via Binding to VEGFR-2 in Ovarian Cancer.
Neoplasms
Novel anti-inflammatory role for glycogen synthase kinase-3beta in the inhibition of tumor necrosis factor-alpha- and interleukin-1beta-induced inflammatory gene expression.
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Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
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Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice.
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Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma.
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Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors.
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Novel germline STK11 variants and breast cancer phenotype identified in an Indian cohort of Peutz-Jeghers syndrome.
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Novel GSK-3beta inhibitors from sequential virtual screening.
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Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors.
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Novel indeno[1,2-b]indoloquinones as inhibitors of the human protein kinase CK2 with antiproliferative activity towards a broad panel of cancer cell lines.
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Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain.
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Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.
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Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead.
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Novel inhibitors of Rho-kinase mediated neuroinflammatory pathways and their potential application in recovery of injured spinal cord.
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Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold.
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Novel Insights into the Biochemical Mechanism of CK1? and its Functional Interplay with DDX3X.
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Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction.
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Novel interacting proteins identified by tandem affinity purification coupled to nano LC-MS/MS interact with ribosomal S6 protein kinase 4 (RSK4) and its variant protein (RSK4m).
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Novel LRRK2 mutations and other rare, non-BAP1-related candidate tumor predisposition gene variants in high-risk cancer families with mesothelioma and other tumors.
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Novel players in multiple myeloma pathogenesis: role of protein kinases CK2 and GSK3.
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Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK Driven Cancers.
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Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility.
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Novel proteins that interact with the COOH-terminal cytosolic routing determinants of an integral membrane peptide-processing enzyme.
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Novel small molecule protein kinase CK2 inhibitors exert potent antitumor effects on T98G and SEGA cells in vitro.
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Novel small molecule Raf kinase inhibitors for targeted cancer therapeutics.
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Novel therapeutic applications of nitric oxide donors in cancer: roles in chemo- and immunosensitization to apoptosis and inhibition of metastases.
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Novel treatment strategies for soft tissue sarcoma.
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Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.
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Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.
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Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.
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NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes.
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NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States.
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NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP.
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NUCKS nuclear elevated expression indicates progression and prognosis of ovarian cancer.
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NUCKS1 Acts as a Promising Novel Biomarker for the Prognosis of Patients with Hepatocellular Carcinoma.
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NUCKS1 overexpression is a novel biomarker for recurrence-free survival in cervical squamous cell carcinoma.
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Nuclear Accumulation of B-Catenin in Human Endocrine Tumors: Association with Ki-67 (MIB-1) Proliferative Activity.
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Nuclear Aurora kinase A triggers programmed death-ligand 1-mediated immune suppression by activating MYC transcription in triple-negative breast cancer.
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Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells.
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Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1.
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Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity.
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Nuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells by PI3K/Akt signaling pathway.
Neoplasms
Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-?-inducible protein 10 in a casein kinase 2-dependent manner.
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Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer.
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Nuclear localization of the CK2?-subunit correlates with poor prognosis in clear cell renal cell carcinoma.
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Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B.
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Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling.
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Nuclear/cytoplasmic localization of Akt activity in the cell cycle.
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Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3.
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Nucleolin (C23), a physiological substrate for casein kinase II.
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Nucleophosmin is overexpressed in thyroid tumors.
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Nucleoside and N-acetyldopamine derivatives from the insect Aspongopus chinensis.
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Nucleus-located PDK1 regulates growth, invasion and migration of breast cancer cells.
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NUT Midline Carcinoma: Morphoproteomic Characterization with Genomic and Therapeutic Correlates.
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O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.
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Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have progressed following first-line therapy (GOLD): a double-blind, randomised, placebo-controlled, phase 3 trial.
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Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates diabetes-induced renal damage through the advanced glycation end product-related pathway in db/db mice.
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Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma.
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Oligonucleotide sequence-specific inhibition of gene expression, tumor growth inhibition, and modulation of cAMP signaling by an RNA-DNA hybrid antisense targeted to protein kinase A RIalpha subunit.
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Omega-3 and omega-6 fatty acids and PGE2 stimulate the growth of normal but not tumor mouse mammary epithelial cells: evidence for alterations in the signaling pathways in tumor cells.
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Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer.
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On CK2 regulation of chronic lymphocytic leukemia cell viability.
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Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors.
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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
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Oncogenic alterations in primary human lung-tumors (review).
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Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells.
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Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.
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Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis.
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Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice.
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Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors.
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Oncogenic role of nuclear accumulated Aurora-A.
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Oncolysis of canine tumor cells by myxoma virus lacking the serp2 gene.
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Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability.
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One Novel Deletion and One Splicing Mutation of the LKB1 Gene in Two Chinese Patients with Peutz-Jeghers Syndrome.
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One-thousand-and-one substrates of protein kinase CK2?
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ONECUT2 Accelerates Tumor Proliferation Through Activating ROCK1 Expression in Gastric Cancer.
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Open-label, multicenter, phase 1 study of alisertib (MLN8237), an aurora A kinase inhibitor, with docetaxel in patients with solid tumors.
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Opposite estrogen effects of estrone and 2-hydroxyestrone on MCF-7 sensitivity to the cytotoxic action of cell growth, oxidative stress and inflammation activity.
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Opposite role of Ras in tumor necrosis factor-alpha-induced cell cycle regulation: competition for Raf kinase.
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Optimal IL-7R-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on CK2 activity.
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Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
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Optimization of Protein-Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy.
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Oral Administration of Apigenin Inhibits Metastasis through AKT/P70S6K1/MMP-9 Pathway in Orthotopic Ovarian Tumor Model.
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Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production.
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Oral mucosal stigmata in hereditary-cancer syndromes: From germline mutations to distinctive clinical phenotypes and tailored therapies.
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Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
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Oryza sativa (Rice) Hull Extract Inhibits Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages by Suppressing Extracellular Signal-regulated Kinase, c-Jun N-terminal Kinase, and Nuclear Factor-?B Activation.
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Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity.
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Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma.
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Outer membrane proteins of wild-type and intimin-deficient enteropathogenic Escherichia coli induce Hep-2 cell death through intrinsic and extrinsic pathways of apoptosis.
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Over-expression of 14-3-3zeta is an early event in oral cancer.
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Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters.
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Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model.
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Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment.
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Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer.
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Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway.
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Overexpression and amplification of STK15 in human gliomas.
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Overexpression and Selective Anticancer Efficacy of ENO3 in STK11 Mutant Lung Cancers.
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Overexpression of 14-3-3? promotes tumor metastasis and indicates poor prognosis in breast carcinoma.
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Overexpression of 14-3-3gamma causes polyploidization in H322 lung cancer cells.
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Overexpression of A-kinase anchoring protein 12A activates sterol regulatory element binding protein-2 and enhances cholesterol efflux in hepatic cells.
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Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.
Neoplasms
Overexpression of Aurora-A enhances invasion and matrix metalloproteinase-2 expression in esophageal squamous cell carcinoma cells.
Neoplasms
Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer.
Neoplasms
Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation.
Neoplasms
Overexpression of cyclin D1 is associated with elevated levels of MAP kinases, Akt and Pak1 during diethylnitrosamine-induced progressive liver carcinogenesis.
Neoplasms
Overexpression of HIPK2 attenuates spinal cord injury in rats by modulating apoptosis, oxidative stress, and inflammation.
Neoplasms
Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells.
Neoplasms
Overexpression of human ABCB1 in cancer cells leads to reduced activity of GSK461364, a specific inhibitor of polo-like kinase 1.
Neoplasms
Overexpression of integrin-linked kinase (ILK) is associated with tumor progression and an unfavorable prognosis in patients with colorectal cancer.
Neoplasms
Overexpression of integrin-linked kinase (ILK) promotes glioma cell invasion and migration and down-regulates E-cadherin via the NF-?B pathway.
Neoplasms
Overexpression of integrin-linked kinase (ILK) promotes migration and invasion of colorectal cancer cells by inducing epithelial-mesenchymal transition via NF-?B signaling.
Neoplasms
Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt.
Neoplasms
Overexpression of nuclear protein kinase CK2 ? catalytic subunit (CK2?) as a poor prognosticator in human colorectal cancer.
Neoplasms
Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion.
Neoplasms
Overexpression of PBK/TOPK Contributes to Tumor Development and Poor Outcome of Esophageal Squamous Cell Carcinoma.
Neoplasms
Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma.
Neoplasms
Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer.
Neoplasms
Overexpression of Pim-1 during progression of prostatic adenocarcinoma.
Neoplasms
Overexpression of protein kinase A - RIalpha reduces lipofection efficiency of cisplatin-resistant human tumor cells.
Neoplasms
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
Neoplasms
Overexpression of Raf-1 and ERK1/2 in sacral chordoma and association with tumor recurrence.
Neoplasms
Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis.
Neoplasms
Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma.
Neoplasms
Overexpression of RKIP inhibits cell invasion in glioma cell lines through upregulation of miR-98.
Neoplasms
Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.
Neoplasms
Overexpression of ROCK1 promotes cancer cell proliferation and is associated with poor prognosis in human urothelial bladder cancer.
Neoplasms
Overexpression of the LKB1 gene inhibits lung carcinoma cell proliferation partly through degradation of c-myc protein.
Neoplasms
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Neoplasms
Overexpression of UBR5 promotes tumor growth in gallbladder cancer via PTEN/PI3K/Akt signal pathway.
Neoplasms
Overexpression of wild-type p53 overrides the mitogenic effect of ri-alpha subunit of protein-kinase-a in human breast cells.
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Overexpression of YWHAZ as an independent prognostic factor in adenocarcinoma of the esophago-gastric junction.
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Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma.
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Overview of linkage analysis: application to pancreatic cancer.
Neoplasms
Oxidant stress promotes disease by activating CaMKII.
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Oxidative CaMKII as a potential target for inflammatory disease (Review).
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Oxidative phosphorylation promotes primary melanoma invasion.
Neoplasms
Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.
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Oxytocin receptors in human adenocarcinomas of the endometrium: presence and biological significance.
Neoplasms
p-Akt and its relationship with clinicopathological features and survival in oral squamous cell carcinoma: an immunohistochemical study.
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P-Akt expression distinguishes two types of malignant rhabdoid tumors.
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p-AKT overexpression in primary renal cell carcinomas and their metastases.
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p16(INK4A) promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner.
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p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-?B/IL-6 activation in renal cell carcinoma.
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P21-Activated Kinase 4 (PAK4) Inhibitors as Potential Cancer Therapy.
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P21-activated kinase 4 involves TSH induced papillary thyroid cancer cell proliferation.
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p21-activated kinase 4 regulates HIF-1? translation in cancer cells.
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p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells.
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p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions.
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P2Y receptor-mediated inhibition of tumor necrosis factor alpha -stimulated stress-activated protein kinase activity in EAhy926 endothelial cells.
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p300-mediated acetylation increased the protein stability of HIPK2 and enhanced its tumor suppressor function.
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p38 and Casein Kinase 2 Mediate Ribonuclease 1 Repression in Inflamed Human Endothelial Cells via Promoter Remodeling Through Nucleosome Remodeling and Deacetylase Complex.
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p38 kinase and c-Jun N-terminal kinase oppositely regulates tumor necrosis factor alpha-induced vascular cell adhesion molecule-1 expression and cell adhesion in chondrosarcoma cells.
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p38 mitogen activated protein kinase mediates both death signaling and functional depression in the heart.
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p38 pathway kinases as anti-inflammatory drug targets.
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p53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.
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p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation.
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p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells.
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p53 suppresses 14-3-3? by stimulating proteasome-mediated 14-3-3? protein degradation.
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P53 suppresses expression of the 14-3-3gamma oncogene.
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P53 suppresses ribonucleotide reductase via inhibiting mTORC1.
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p53-deficient cells display increased sensitivity to anthracyclines after loss of the catalytic subunit of the DNA-dependent protein kinase.
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p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2.
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P65-mediated miR-590 inhibition modulates the chemoresistance of osteosarcoma to doxorubicin through targeting wild-type p53-induced phosphatase 1.
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p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells.
Neoplasms
p70 S6 kinase limits tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblast-like cells.
Neoplasms
p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells.
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p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer.
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PACAP action in nervous system development, regeneration, and neuroblastoma cell proliferation.
Neoplasms
Paclitaxel is preferentially cytotoxic to human cervical tumor cells with low Raf-1 kinase activity: implications for paclitaxel-based chemoradiation regimens.
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Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways.
Neoplasms
PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21.
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PAK1 tyrosine phosphorylation is required to induce epithelial-mesenchymal transition and radioresistance in lung cancer cells.
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PAK4 inhibition improves PD-1 blockade immunotherapy.
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PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity.
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PAK4 methylation by the methyltransferase SETD6 attenuates cell adhesion.
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PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth.
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PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer.
Neoplasms
PAK4, a target of miR-9-5p, promotes cell proliferation and inhibits apoptosis in colorectal cancer.
Neoplasms
PAK6 promotes cervical cancer progression through activation of the Wnt/?-catenin signaling pathway.
Neoplasms
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance.
Neoplasms
Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells.
Neoplasms
Pancreatic Neuroendocrine Tumors and EMT Behavior are Driven by the CSC Marker DCLK1.
Neoplasms
Panel of Autoimmune Markers for Noninvasive Diagnosis of Minimal-Mild Endometriosis: A Multicenter Study.
Neoplasms
PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced injury through the ERK signaling pathway in N2A cells.
Neoplasms
PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.
Neoplasms
PAR-5 is a PARty hub in the germline: Multitask proteins in development and disease.
Neoplasms
Paracrine Effects of Mesenchymal Stem Cells-Conditioned Medium on Microglial Cytokines Expression and Nitric Oxide Production.
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Parkin, PINK1 and DJ1 as possible modulators of mTOR pathway in ganglioglioma.
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Parkinson disease, cancer, and LRRK2: Causation or association?
Neoplasms
PARP10 suppresses tumor metastasis through regulation of Aurora A activity.
Neoplasms
Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cells.
Neoplasms
Passive cigarette smoke exposure inhibits ultraviolet light B-induced skin tumors in SKH-1 hairless mice by blocking the nuclear factor kappa B signalling pathway.
Neoplasms
Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells.
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Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.
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Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
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Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Neoplasms
Patterns of gene promoter methylation in squamous cell cancer of the head and neck.
Neoplasms
Patterns of Innate or Acquired Resistance to Anticancer Drugs: Our Experience to Overcome It.
Neoplasms
PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma.
Neoplasms
PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.
Neoplasms
PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation.
Neoplasms
PD-L1 Expression and Its Regulation in Lung Adenocarcinoma with ALK Translocation.
Neoplasms
PD-L1 expression, tumor mutational burden and cancer gene mutations are stronger predictors of benefit from immune checkpoint blockade than HLA class I genotype in non-small cell lung cancer.
Neoplasms
PD-L1, PDK-1 and p-Akt are correlated in patients with papillary thyroid carcinoma.
Neoplasms
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
Neoplasms
PDK1: At the crossroad of cancer signaling pathways.
Neoplasms
Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice.
Neoplasms
Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ?50%: real-world data.
Neoplasms
Pentoxifylline for Diabetic Nephropathy: an Important Opportunity to Re-purpose an Old Drug?
Neoplasms
Peptide Substrates for Rho-Associated Kinase 2 (Rho-Kinase 2/ROCK2).
Neoplasms
Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors.
Neoplasms
Peroxiredoxin 1 is involved in disassembly of flagella and cilia.
Neoplasms
Peroxisome proliferator-activated receptor gamma as a novel target in cancer therapy: binding and activation by an aromatic fatty acid with clinical antitumor activity.
Neoplasms
Perspectives of Protein Kinase C (PKC) Inhibitors as Anti-Cancer Agents.
Neoplasms
Pharmacodynamic monitoring of BAY 43-9006 (Sorafenib) in phase I clinical trials involving solid tumor and AML/MDS patients, using flow cytometry to monitor activation of the ERK pathway in peripheral blood cells.
Neoplasms
Pharmacodynamic trial of nimotuzumab in unresectable squamous cell carcinoma of the head and neck: a SENDO Foundation study.
Neoplasms
Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors.
Neoplasms
Pharmacoinformatic Approaches to Design Novel Inhibitors of Protein Kinase B Pathways in Cancer.
Neoplasms
Pharmacokinetic characterization of CK2 inhibitor CX-4945.
Neoplasms
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts.
Neoplasms
Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib in Adult Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Dysfunction.
Neoplasms
Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome.
Neoplasms
Pharmacological evidence for lithium-induced neuroprotection against methamphetamine-induced neurodegeneration via Akt-1/GSK3 and CREB-BDNF signaling pathways.
Neoplasms
Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors.
Neoplasms
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
Neoplasms
Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma.
Neoplasms
Pharmacological postconditioning with sevoflurane activates PI3K/AKT signaling and attenuates cardiopulmonary bypass-induced lung injury in dog.
Neoplasms
Pharmacological targets and mechanisms of calycosin against meningitis.
Neoplasms
Pharmacophore development, drug-likeness analysis, molecular docking, and molecular dynamics simulations for identification of new CK2 inhibitors.
Neoplasms
Pharmacophore feature-based virtual screening for finding potent GSK-3 inhibitors using molecular docking and dynamics simulations.
Neoplasms
Pharmacophore generation and atom-based 3D-QSAR of novel quinoline-3-carbonitrile derivatives as Tpl2 kinase inhibitors.
Neoplasms
Pharmacophore identification and validation study of CK2 inhibitors using CoMFA/CoMSIA.
Neoplasms
Pharmacophore modeling, virtual screening, docking and in silico ADMET analysis of protein kinase B (PKB ?) inhibitors.
Neoplasms
Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors.
Neoplasms
Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose.
Neoplasms
Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase.
Neoplasms
Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors.
Neoplasms
Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies.
Neoplasms
Phase I dose escalation and pharmacokinetic study of oral enzastaurin (LY317615) in advanced solid tumors.
Neoplasms
Phase I Dose-Escalation Trial of Checkpoint Kinase 1 Inhibitor MK-8776 As Monotherapy and in Combination With Gemcitabine in Patients With Advanced Solid Tumors.
Neoplasms
Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT.
Neoplasms
Phase I Pharmacokinetic/Pharmacodynamic Study of MLN8237, an Investigational, Oral, Selective Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.
Neoplasms
Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours.
Neoplasms
Phase I Study of Aurora A Kinase Inhibitor Alisertib (MLN8237) in Combination With Selective VEGFR Inhibitor Pazopanib for Therapy of Advanced Solid Tumors.
Neoplasms
Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations.
Neoplasms
Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors.
Neoplasms
Phase I Study of Liposome-Encapsulated c-raf Antisense Oligodeoxyribonucleotide Infusion in Combination with Radiation Therapy in Patients with Advanced Malignancies.
Neoplasms
Phase I Study of LY2606368, a Checkpoint Kinase 1 Inhibitor, in Patients With Advanced Cancer.
Neoplasms
Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Neoplasms
Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.
Neoplasms
Phase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine in patients with refractory solid tumors.
Neoplasms
Phase I study of the selective Aurora A kinase inhibitor MLN8054 in patients with advanced solid tumors: safety, pharmacokinetics, and pharmacodynamics.
Neoplasms
Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors.
Neoplasms
Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors.
Neoplasms
Phase I trial of everolimus plus sorafenib for patients with advanced renal cell cancer.
Neoplasms
Phase I trial of sorafenib following liver transplantation in patients with high-risk hepatocellular carcinoma.
Neoplasms
Phase I/II RAF kinase inhibitors in cancer therapy.
Neoplasms
Phase IB study of sorafenib in combination with gemcitabine and cisplatin in patients with refractory solid tumors.
Neoplasms
Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study.
Neoplasms
Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
Neoplasms
Phase II trial of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma after disease progression on sorafenib.
Neoplasms
Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.
Neoplasms
Phenotypic Effects of Homeodomain-Interacting Protein Kinase 2 Deletion in Mice.
Neoplasms
Phenotypic Profiling of Raf Inhibitors and Mitochondrial Toxicity in 3D Tissue Using Biodynamic Imaging.
Neoplasms
Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.
Neoplasms
PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.
Neoplasms
PHLPP1 splice variants differentially regulate AKT and PKC? signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus.
Neoplasms
Phorbol 12,13 dibutyrate behaves in a tumor-inhibitory manner in esophageal adenocarcinoma cell lines.
Neoplasms
Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells.
Neoplasms
Phosphatidylinositol Phosphate 5-Kinase I? and Phosphoinositide 3-Kinase/Akt Signaling Couple to Promote Oncogenic Growth.
Neoplasms
Phosphatidylinositol-3'-kinase/AKT signalling is essential in synovial sarcoma.
Neoplasms
Phospho-?Np63?-dependent regulation of autophagic signaling through transcription and micro-RNA modulation.
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Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer.
Neoplasms
Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines().
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Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.
Neoplasms
Phospho-Form Specific Substrates of Protein Kinase B (AKT1).
Neoplasms
Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapy.
Neoplasms
Phosphoinositide 3-kinase (PI3K) pathway inhibitors in solid tumors: From laboratory to patients.
Neoplasms
Phosphoinositide-3-kinase ? inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells.
Neoplasms
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Neoplasms
Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway.
Neoplasms
Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.
Neoplasms
Phosphoproteomic Landscape of AML Cells Treated with the ATP-Competitive CK2 Inhibitor CX-4945.
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Phosphoproteomics Analysis Reveals a Potential Role of CHK1 in Regulation of Innate Immunity through IRF3.
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Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer.
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Phosphorylated Akt Expression as a Favorable Prognostic Factor for Patients Undergoing Curative Resection and Adjuvant Chemoradiotherapy for Proximal Extrahepatic Bile Duct Cancer.
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Phosphorylated AKT expression in tumor-adjacent normal tissue is associated with poor prognosis in patients with hepatocellular carcinoma.
Neoplasms
Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.
Neoplasms
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis.
Neoplasms
Phosphorylated Akt1 in human breast cancer measured by direct sandwich enzyme-linked immunosorbent assay: Correlation with clinicopathological features and tumor VEGF-signaling system component levels.
Neoplasms
Phosphorylated p70S6K expression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
Neoplasms
Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma.
Neoplasms
Phosphorylated-Akt overexpression is associated with a higher risk of brain metastasis in patients with non-small cell lung cancer.
Neoplasms
Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A.
Neoplasms
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.
Neoplasms
Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.
Neoplasms
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.
Neoplasms
Phosphorylation is involved in the regulation of the taurine influx via the beta-system in Ehrlich ascites tumor cells.
Neoplasms
Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer.
Neoplasms
Phosphorylation of Akt (Ser473) predicts poor clinical outcome in oropharyngeal squamous cell cancer.
Neoplasms
Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis.
Neoplasms
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells.
Neoplasms
Phosphorylation of chromosomal proteins during the transition of a normal plant cell to a crown gall tumor cell.
Neoplasms
Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase.
Neoplasms
Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes.
Neoplasms
Phosphorylation of glycogen synthase kinase-3 beta at serine 9 confers cisplatin resistance in ovarian cancer cells.
Neoplasms
Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor.
Neoplasms
Phosphorylation of human TRM9L integrates multiple stress-signaling pathways for tumor growth suppression.
Neoplasms
Phosphorylation of IRS4 by CK1?2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway.
Neoplasms
Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor ?-mediated neurotoxicity.
Neoplasms
Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.
Neoplasms
Phosphorylation of SAV1 by mammalian ste20-like kinase promotes cell death.
Neoplasms
Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon.
Neoplasms
Phosphorylation regulates the stability of the regulatory CK2beta subunit.
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Phosphorylation-Dependent Inhibition of Akt1.
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Photothermal therapy with AuNRs and EGFRmAb-AuNRs inhibits subcutaneous transplantable hypopharyngeal tumors in nude mice.
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Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo.
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Physcion 8-O-?-glucopyranoside induces mitochondria-dependent apoptosis of human oral squamous cell carcinoma cells via suppressing survivin expression.
Neoplasms
Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells.
Neoplasms
Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
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Physicochemical properties of novel protein kinase inhibitors in relation to their substrate specificity for drug transporters.
Neoplasms
Physiological concentrations of divalent magnesium ion activate the serine/threonine specific protein kinase ERK2.
Neoplasms
Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-alpha dependence on c-Jun N-terminal kinase.
Neoplasms
Physiological roles of PKB/Akt isoforms in development and disease.
Neoplasms
Physiologically-based pharmacokinetics and molecular pharmacodynamics of 17-(allylamino)-17-demethoxygeldanamycin and its active metabolite in tumor-bearing mice.
Neoplasms
Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression.
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PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro.
Neoplasms
PI3K/Akt and GSK-3beta prevents in a differential fashion the malignant phenotype of colorectal cancer cells.
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PI3K/AKT pathway genetic alterations and dysregulation of expression in bladder cancer.
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PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects.
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Pictilisib Enhances the Antitumor Effect of Doxorubicin and Prevents Tumor-Mediated Bone Destruction by Blockade of PI3K/AKT Pathway.
Neoplasms
PIK3CA mutation confers resistance to chemotherapy in triple-negative breast cancer by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway.
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Pim family kinases enhance tumor growth of prostate cancer cells.
Neoplasms
PIM kinase inhibitors: Structural and pharmacological perspectives.
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Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia.
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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.
Neoplasms
Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.
Neoplasms
PIM-1 kinase inhibitor SMI-4a exerts antitumor effects in chronic myeloid leukemia cells by enhancing the activity of glycogen synthase kinase 3?.
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Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway.
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PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia.
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Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.
Neoplasms
PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.
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Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.
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Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation.
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Pim-3 is a Critical Risk Factor in Development and Prognosis of Prostate Cancer.
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PIM1 Kinase as a Target in Prostate Cancer: Roles in Tumorigenesis, Castration Resistance, and Docetaxel Resistance.
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PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.
Neoplasms
Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity.
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PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma.
Neoplasms
Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation.
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PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-?B signaling pathway.
Neoplasms
Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure.
Neoplasms
Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway.
Neoplasms
Piperlongumine inhibits head and neck squamous cell carcinoma proliferation by docking to Akt.
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Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization.
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PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
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PKA signaling drives mammary tumorigenesis through Src.
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PKC? promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma.
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PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester.
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PKD1 negatively regulates cell invasion, migration and proliferation ability of human osteosarcoma.
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Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-d]pyrimidines for Targeting Hepatocellular Carcinoma.
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Platelet-activating factor enhances tumor metastasis via the ROS-dependent protein kinase CK2-mediated NF-?B activation.
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Platelet-derived endothelial cell growth factor mediates Rho-associated coiled-coil domain kinase messenger RNA expression and promotes cell motility.
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Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling.
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PLK-1 Expression is Associated with Histopathological Response to Neoadjuvant Therapy of Hepatic Metastasis of Colorectal Carcinoma.
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Plk1 Activation by Ste20-like Kinase (Slk) Phosphorylation and Polo-Box Phosphopeptide Binding Assayed with the Substrate Translationally Controlled Tumor Protein (TCTP).
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PLK1 targets CtIP to promote microhomology-mediated end joining.
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PLS and shape-based similarity analysis of maleimides - GSK-3 inhibitors.
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PM2.5-associated nitro-PAH exposure promotes tumor cell metastasis through Hippo-YAP mediated transcriptional regulation.
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PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage.
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Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice.
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Polo-like kinase 3, hypoxic responses, and tumorigenesis.
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Polo-like kinase-1 as novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of siRNA and the Polo-like kinase-1 targeting drug BI 2536.
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Polo-like kinase1, a new target for antisense tumor therapy.
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Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.
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Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells.
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Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer.
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Polycystic ovary syndrome (PCOS) with melanocytic mucosal macules: the role of STK11 gene polymorphisms in PCOS and Peutz-Jeghers syndrome.
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Polymorphism rs1801516 (G?>?A) in the ATM gene is not associated with overall cancer risk: an updated meta-analysis.
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Polymorphisms of DNA repair and xenobiotic genes predispose to CpG island methylation in non-neoplastic gastric mucosa.
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Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types.
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POSH promotes cell survival in Drosophila and in human RASF cells.
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Positioning of a molecular-targeted agent, sorafenib, in the treatment algorithm for hepatocellular carcinoma and implication of many complete remission cases in Japan.
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Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues.
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Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review.
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Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function.
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Possible Predictive Markers of Response to Therapy in Esophageal Squamous Cell Cancer.
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Possible relevance between prohormone convertase 2 expression and tumor growth in human adrenocorticotropin-producing pituitary adenoma.
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Post-conditioning with gradually increased reperfusion provides better cardioprotection in rats.
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Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells.
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Posttranslational modifications regulate HIPK2, a driver of proliferative diseases.
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Potassium channel-blockers as therapeutic agents to interfere with bone resorption of periodontal disease.
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Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.
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Potential Anti-Skin Aging Effect of (-)-Catechin Isolated from the Root Bark of Ulmus davidiana var. japonica in Tumor Necrosis Factor-?-Stimulated Normal Human Dermal Fibroblasts.
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Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis.
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Potential of casein kinase I in digestive cancer screening.
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Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers.
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Potential role of PKC inhibitors in the treatment of hematological malignancies.
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Potentially useful markers for desmoplastic melanoma: an analysis of KBA.62, p-AKT, and ezrin.
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Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT.
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PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells.
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PP2AC? deficiency impairs early cortical development through inducing DNA damage in neuroprojenitor cells.
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PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion.
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PPAR?/? promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling.
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Prader-Willi Syndrome due to an Unbalanced de novo Translocation t(15;19)(q12;p13.3).
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PRAS40: target or modulator of mTORC1 signalling and insulin action?
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Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive mice.
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Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors.
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Preclinical Drug Metabolism and Pharmacokinetics, and Prediction of Human Pharmacokinetics and Efficacious Dose of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237).
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Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization.
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Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.
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Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney cancer.
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Preconditioning with 1,25-dihydroxyvitamin D3 protects against subsequent ischemia-reperfusion injury in the rat kidney.
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Prediabetes linked to excess glucagon in transgenic mice with pancreatic active AKT1.
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Predicted mechanisms of resistance to mTOR inhibitors.
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Predicting CK2 beta-dependent substrates using linear patterns.
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Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation.
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Predictive and pharmacodynamic biomarker studies in tumor and skin tissue samples of patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with erlotinib.
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Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors.
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Predictive factors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients.
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Predictive factors for the sensitivity of radiotherapy and prognosis of esophageal squamous cell carcinoma.
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Predictive simulation approach for designing cancer therapeutic regimens with novel biological mechanisms.
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Prednisolone Suppresses the Extracellular Release of HMGB-1 and Associated Inflammatory Pathways in Kawasaki Disease.
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Predominance of mTORC1 over mTORC2 in the regulation of proliferation of ovarian cancer cells: therapeutic implications.
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Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival.
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Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.
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Prenatal diagnosis in a hereditary Peutz-Jeghers syndrome family with high cancer risk.
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Preoperative clinical and tumor genomic features associated with pathologic lymph node metastasis in clinical stage I and II lung adenocarcinoma.
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Preparation and characterization of CK2 inhibitor-loaded cyclodextrin nanoparticles for drug delivery.
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Preparation of curcumin micelles and the in vitro and in vivo evaluation for cancer therapy.
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Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis.
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Pretreatment With Erythropoietin Attenuates Intestinal Ischemia Reperfusion Injury by Further Promoting PI3K/Akt Signaling Activation.
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Prevalence and prognostic relevance of BrafV600E mutation in colorectal carcinomas from Kashmir (North India) valley.
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Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC).
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Prevalence of ATM Sequence Variants in Northern Plains American Indian Cancer Patients.
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Prevalence of cancer in Parkinson's disease related to R1441G and G2019S mutations in LRRK2.
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Prevalence of deleterious germline variants in risk genes including BRCA1/2 in consecutive ovarian cancer patients (AGO-TR-1).
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Prevalence of deleterious mutations among patients with breast cancer referred for multigene panel testing in a Romanian population.
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Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy.
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Prevention of Prostate Cancer with Oleanane Synthetic Triterpenoid CDDO-Me in the TRAMP Mouse Model of Prostate Cancer.
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Prevention of tumour cell apoptosis associated with sustained protein kinase B phosphorylation is more sensitive to regulation by insulin signalling than stimulation of proliferation and extracellular signal-regulated kinase.
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Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade.
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Primary pigmented nodular adrenocortical disease reveals insulin-like growth factor binding protein-2 regulation by protein kinase A.
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Primate-specific miRNA-637 inhibited tumorigenesis in human pancreatic ductal adenocarcinoma cells by suppressing Akt1 expression.
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Primers on molecular pathways. The glycogen synthase kinase-3beta.
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Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
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Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3.
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PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.
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PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.
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PRKAR1A gene analysis and protein kinase A activity in endometrial tumors.
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PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes.
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PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma.
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PRKAR2B-HIF-1? loop promotes aerobic glycolysis and tumour growth in prostate cancer.
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PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim.
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PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
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PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.
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Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin.
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Pro-necrotic molecules impact local immunosurveillance in human breast cancer.
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Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.
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Pro-Oxidant Effect of Resveratrol on Human Breast Cancer MCF-7 Cells is Associated with CK2 Inhibition.
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Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B.
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Proapoptic and immunotoxic effects of sulfur-fumigated polysaccharides from Smilax glabra Roxb. in RAW264.7?cells.
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Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells.
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Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.
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Probing the 14-3-3 Isoform-Specificity Profile of Protein-Protein Interactions Stabilized by Fusicoccin A.
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Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
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Prognostic and predictive values of pERK1/2 and pAkt-1 expression in non-small cell lung cancer patients treated with adjuvant chemotherapy.
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Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
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Prognostic implications of phosphatidylinositol 3-kinase/AKT signaling pathway activation in gastric carcinomas.
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Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma.
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Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-Analysis.
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Prognostic role of TPL2 in early?stage non?small cell lung cancer.
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Prognostic significance and tumor-immune infiltration of mTOR in clear cell renal cell carcinoma.
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Prognostic significance of 14-3-3? overexpression in advanced non-small cell lung cancer.
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Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.
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Prognostic significance of activated AKT expression in soft-tissue sarcoma.
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Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer.
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Prognostic significance of Aurora-A expression in human bladder cancer.
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Prognostic significance of death-associated protein-kinase expression in hepatocellular carcinomas.
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Prognostic significance of hypermethylation of death-associated protein kinase (DAPK) gene CpG island in dogs with high-grade B-cell lymphoma.
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Prognostic significance of nemo-like kinase (NLK) expression in patients with gallbladder cancer.
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Prognostic value and functional role of ROCK2 in pediatric Ewing sarcoma.
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Prognostic value of activated Akt expression in oral squamous cell carcinoma.
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Prognostic Values of EPDR1 Hypermethylation and Its Inhibitory Function on Tumor Invasion in Colorectal Cancer.
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Programmed cell death 4 nuclear loss and miR-21 or activated Akt overexpression in esophageal squamous cell carcinogenesis.
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Progress and challenges of predictive biomarkers of anti PD-1/PD-L1 immunotherapy: A systematic review.
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Progress in cancer genetics: lessons from pancreatic cancer.
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Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs-deficient context.
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Proinflammatory cytokines downregulate connexin 43-gap junctions via the ubiquitin-proteasome system in rat spinal astrocytes.
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Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase a regulatory subunit 1A protein.
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Proliferative and anti-proliferative effects of Thymosin alpha1 on cells are associated with manipulation of cellular ROS levels.
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Prologation of c-Jun N-terminal kinase is associated with cell death induced by tumor necrosis factor alpha in human chondrocytes.
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Promising gene therapy using an adenovirus vector carrying REIC/Dkk-3 gene for the treatment of biliary cancer.
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Promoter hypermethylation in primary squamous cell carcinoma of the oral cavity and oropharynx: a study of a Brazilian cohort.
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Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients.
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Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer.
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Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
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Promoter Hypermethylation of the ATM Gene as a Novel Biomarker for Breast Cancer
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Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype.
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Promoter methylation and expression of Raf kinase inhibitory protein in esophageal squamous cell carcinoma.
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Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.
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Promoter methylation of Raf kinase inhibitory protein: A significant prognostic indicator for patients with gastric adenocarcinoma.
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Promoter methylation status of multiple genes in brain metastases of solid tumors.
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Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia.
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Propofol attenuates the adhesion of tumor and endothelial cells through inhibiting glycolysis in human umbilical vein endothelial cells.
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Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
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Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis.
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Prostaglandin E2-protein kinase A signaling and protein phosphatases-1 and -2A regulate human head and neck squamous cell carcinoma motility, adherence, and cytoskeletal organization.
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Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.
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Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
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Protective effect of vascular endothelial growth factor against cardiopulmonary bypass-associated acute kidney injury in beagles.
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Protective Effects of Geniposide on Hepatic Ischemia/Reperfusion Injury.
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Protective mechanism of morin against ultraviolet B-induced cellular senescence in human keratinocyte stem cells.
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Protective role of selenium against over-expression of cancer-related apoptotic genes induced by o-cresol in rats.
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Protein activation dynamics in cells and tumor micro arrays assessed by time resolved förster resonance energy transfer.
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Protein alterations in infiltrating ductal carcinomas of the breast as detected by nonequilibrium pH gradient electrophoresis and mass spectrometry.
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Protein and mRNA characterization in human colorectal carcinoma cell lines with different metastatic potentials.
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Protein kinase 2 (CK2): a potential regulator of immune cell development and function in cancer.
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Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis.
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Protein kinase A alterations in adrenocortical tumors.
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Protein kinase a alterations in endocrine tumors.
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Protein kinase A and its role in human neoplasia: the Carney complex paradigm.
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Protein kinase A antagonist inhibits ?-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice.
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Protein kinase A as a biological target in cancer therapy.
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Protein kinase A as target for novel integrated strategies of cancer therapy.
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Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages.
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Protein kinase A defects and cortisol-producing adrenal tumors.
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Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
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Protein kinase a in cancer.
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Protein kinase A in Carney complex: a new example of cAMP pathway alteration in endocrine tumors.
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Protein kinase A inhibitor proteins (PKIs) divert GPCR-G?s-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth.
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Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation.
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Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion.
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Protein kinase A regulates Lewis lung carcinoma adherence to extracellular matrix components and spontaneous metastasis.
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Protein kinase A regulatory subunit distribution in medulloblastoma.
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Protein kinase A RI-alpha predicts for prostate cancer outcome: analysis of radiation therapy oncology group trial 86-10.
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Protein kinase A serves as a primary pathway in activation of Nur77 expression by gonadotropin-releasing hormone in the LbetaT2 mouse pituitary gonadotroph tumor cell line.
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Protein kinase A type I: a target for cancer therapy.
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Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine.
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Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity.
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Protein kinase A: regulation and receptor-mediated delivery of antisense oligonucleotides and cytotoxic drugs.
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Protein kinase activities in neoplastic squamous epithelia and normal epithelia from the upper aero-digestive tract.
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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
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Protein kinase B/AKT and focal adhesion kinase: two close signaling partners in cancer.
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Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression.
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Protein kinase B: emerging mechanisms of isoform-specific regulation of cellular signaling in cancer.
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Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.
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Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway.
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Protein kinase C? inhibition restores megakaryocytic differentiation of hematopoietic progenitors from primary myelofibrosis patients.
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Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death.
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Protein kinase CK2 activates Nrf2 via autophagic degradation of Keap1 and activation of AMPK in human cancer cells.
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Protein kinase CK2 as regulator of cell survival: implications for cancer therapy.
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Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.
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Protein Kinase CK2 Content in GL261 Mouse Glioblastoma.
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Protein Kinase CK2 in Cancer Energetics.
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Protein kinase CK2 in human diseases.
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Protein kinase CK2 in mammary gland tumorigenesis.
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Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival.
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Protein kinase CK2 inhibition is associated with the destabilization of HIF-1? in human cancer cells.
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Protein kinase CK2 inhibitors: emerging anticancer therapeutic agents?
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Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell lines.
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Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors.
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Protein kinase CK2 modulation of pyruvate kinase M isoforms augments the Warburg effect in cancer cells.
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Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production.
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Protein kinase CK2 signal in neoplasia.
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Protein Kinase CK2: An Emerging Regulator of Immunity.
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Protein kinase CK2? catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
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Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes.
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Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells.
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Protein kinase D as a potential new target for cancer therapy.
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Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion.
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Protein kinase D enzymes: novel kinase targets in pancreatic cancer.
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Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M.
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Protein Kinase D regulates RhoA activity via Rhotekin phosphorylation.
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Protein kinase D signaling in cancer: A friend or foe?
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Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor.
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Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.
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Protein kinase D1 induces G1-phase cell-cycle arrest independent of Checkpoint kinases by phosphorylating Cell Division Cycle Phosphatase 25.
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Protein kinase D1 inhibition interferes with mitosis progression.
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Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer.
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Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation.
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Protein Kinase D1 Is Increased in Tumor Tissue, Correlates With Advanced Tumor Features and Worse Prognosis of Non-Small Cell Lung Cancer.
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Protein Kinase D1 mediates anchorage-dependent and independent growth of tumor cells via the zinc-finger transcription factor Snail1.
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Protein kinase D1 regulates ER?-positive breast cancer cell growth response to 17?-estradiol and contributes to poor prognosis in patients.
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Protein kinase D1 regulates hypoxic metabolism through HIF-1? and glycolytic enzymes incancer cells.
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Protein kinase D1 regulates subcellular localisation and metastatic function of metastasis-associated protein 1.
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Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway.
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Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail.
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Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.
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Protein kinase D1: gatekeeper of the epithelial phenotype and key regulator of cancer metastasis?
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Protein kinase D2 contributes to TNF-?-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3?/?-catenin pathway in hepatocellular carcinoma.
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Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases.
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Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours.
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Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation.
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Protein Kinase D2 Modulates Cell Cycle By Stabilizing Aurora A Kinase at Centrosomes.
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Protein kinase D2 promotes the proliferation of glioma cells by regulating Golgi phosphoprotein 3.
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Protein kinase D2: a versatile player in cancer biology.
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Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.
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Protein kinases and multidrug resistance.
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Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis.
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Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.
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Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase.
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Protein profile changes in the human breast cancer cell line MCF-7 in response to SEL1L gene induction.
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Proteome analysis in the clinical chemistry laboratory: myth or reality?
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Proteometabolomic analysis of transgenic tomato overexpressing oxalate decarboxylase uncovers novel proteins potentially involved in defense mechanism against Sclerotinia.
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Proteomic analysis of differentially expressed proteins in peripheral cholangiocarcinoma.
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Proteomic analysis of novel targets associated with the enhancement of TrkA-induced SK-N-MC cancer cell death caused by NGF.
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Proteomic analysis of p38alpha mitogen-activated protein kinase-regulated changes in membrane fractions of RAS-transformed fibroblasts.
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Proteomic Analysis of Proteins Related to Prognosis of Lung Adenocarcinoma.
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Proteomic analysis of the copper ion-induced stress response in a human embryonic carcinoma cell line.
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Proteomic analysis reveals that 14-3-3sigma is down-regulated in human breast cancer cells.
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Proteomic approach for identification of protein S-nitrosation in mouse gastric mucosa treated with S-nitrosoglutathione.
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Proteomic Changes Induced by Effective Chemopreventive Ratios of n-3:n-6 Fatty Acids and Tamoxifen against MNU-Induced Mammary Cancer in the Rat.
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Proteomic characterization of early lung response to breast cancer metastasis in mice.
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Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway.
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Proteomic profiling of differential display analysis for human oral squamous cell carcinoma: 14-3-3 ? Protein is upregulated in human oral squamous cell carcinoma and dependent on the differentiation level.
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Proteomic profiling of follicular and papillary thyroid tumors.
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Proteomic Profiling of Signaling Proteins in Ten Different Tumor Cell Lines.
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Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer.
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Proteomics detection of S100A6 in tumor tissue interstitial fluid and evaluation of its potential as a biomarker of cholangiocarcinoma.
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Proteomics of dedifferentiation of SK-N-BE2 neuroblastoma cells.
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Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis.
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Proteomics-derived basal biomarker DNA-PKcs is associated with intrinsic subtype and long-term clinical outcomes in breast cancer.
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Proto-Oncogene Serine/Threonine Kinase PIM3 Promotes Cell Migration via Modulating Rho GTPase Signaling.
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Psychotic disorder induced by a combination of sorafenib and BAY86-9766.
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PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase.
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PTEN couples Sema3A signalling to growth cone collapse.
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PTEN gene therapy induces growth inhibition and increases efficacy of chemotherapy in prostate cancer.
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PTEN in osteosarcoma: Recent advances and the therapeutic potential.
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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.
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PTEN, Akt, and GSK3beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments.
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PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma.
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PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1.
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Pulling a MAST1 on Cisplatin Resistance.
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Purification and characterization of a 400-kDa nonhistone chromatin protein that serves as an effective phosphate acceptor for casein kinase II from Ehrlich ascites tumor cells.
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Purification of CK1 by affinity chromatography on immobilised axin.
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Purification of GSK-3 by affinity chromatography on immobilized axin.
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Putting Glioblastoma in Its Place: IRF3 Inhibits Invasion.
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pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.
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Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR.
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Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF).
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Pyrrolocarbazoles as checkpoint 1 kinase inhibitors.
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Pyruvate dehydrogenase kinase 1 and carbonic anhydrase IX targeting in hypoxic tumors.
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Pyruvate dehydrogenase kinase 1 contributes to cisplatin resistance of ovarian cancer through EGFR activation.
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Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer.
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Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1.
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QSAR Model of Indeno[1,2-b]indole Derivatives and Identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-b]furan-3-carboxamide as a Potent CK2 Inhibitor.
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Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells.
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Quantification of XRCC and DNA-PK proteins in cancer cell lines and human tumors by LC-MS/MS.
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Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma.
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Quantitative and correlation analysis of the DNA methylation and expression of DAPK in breast cancer.
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Quantitative and Label-Free Detection of Protein Kinase A Activity Based on Surface-Enhanced Raman Spectroscopy with Gold Nanostars.
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Quantitative protein expression profiling of 14-3-3 isoforms in human renal carcinoma shows 14-3-3 epsilon is involved in limitedly increasing renal cell proliferation.
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Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma.
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Quantitative proteomic dissection of a native 14-3-3? interacting protein complex associated with hepatocellular carcinoma.
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Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient.
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Quinazolino linked 4?-amidopodophyllotoxin conjugates regulate angiogenic pathway and control breast cancer cell proliferation.
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R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells.
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Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells.
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Rac1 activation driven by 14-3-3? dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migration.
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RACK1 affects the progress of G2/M by regulating Aurora-A.
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RAD 001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia.
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Radiation promotes malignant phenotypes through SRC in breast cancer cells.
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Radiation, DNA damage and cancer.
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Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival via the LKB1 pathway.
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Radical nephrectomy and regional lymph node dissection for locally advanced type 2 papillary renal cell carcinoma in an at-risk individual from a family with hereditary leiomyomatosis and renal cell cancer: a case report.
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RADical response puts an exceptional responder in CHKmate: a synthetic lethal curative response to DNA-damaging chemotherapy?
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Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway.
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Radiomics in Differentiated Thyroid Cancer and Nodules: Explorations, Application, and Limitations.
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Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
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Radiosensitising Cancer Using Phosphatidylinositol-3-Kinase (PI3K), Protein Kinase B (AKT) or Mammalian Target of Rapamycin (mTOR) Inhibitors.
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Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo.
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Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells.
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Radiosensitizing Potential of Curcumin in Different Cancer Models.
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Radiosynthesis and in Vivo Evaluation of [(11)C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain.
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Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of the plasma membrane.
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RAF antisense oligonucleotide as a tumor radiosensitizer.
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Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation.
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
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Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer.
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Raf kinase inhibitor protein (RKIP) in cancer.
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Raf Kinase Inhibitor Protein (RKIP) Inhibits Tumor Necrosis Factor-? (TNF-?) Induced Adhesion Molecules Expression in Vascular Smooth Muscle Bells by Suppressing (Nuclear Transcription Factor-?B (NF-kappaB) Pathway.
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Raf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sarcomas.
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Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells.
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Raf kinase inhibitor protein mediated signaling inhibits invasion and metastasis of hepatocellular carcinoma.
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Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice.
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Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3?.
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Raf kinase inhibitor protein suppresses nuclear factor-?B-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression.
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Raf kinase inhibitor protein1 is a myogenic inhibitor with conserved function in avians and mammals.
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RAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer.
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RAF kinase inhibitors in cancer treatment: like a bull in a China shop?
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Raf kinase inhibitors in oncology.
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Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer.
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Raf Kinase Inhibitory Protein Down-Expression Exacerbates Hepatic Fibrosis In Vivo and In Vitro.
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RAF Kinase Inhibitory Protein Expression and Phosphorylation Profiles in Oral Cancers.
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Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint.
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Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
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Raf kinases: Oncogenesis and drug discovery.
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RAF signaling in neuroendocrine neoplasms: from bench to bedside.
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Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion.
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Raf-1 addiction in Ras-induced skin carcinogenesis.
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Raf-1 expression may influence progression to androgen insensitive prostate cancer.
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Raf-1 kinase activity predicts for paclitaxel resistance in TP53mut, but not TP53wt human ovarian cancer cells.
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Raf-1 kinase, epidermal growth factor receptors, and mutant Ras proteins in colonic carcinomas.
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RAF-kinase inhibitor protein (RKIP) downregulation in esophageal cancer and its metastases.
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Raf: a strategic target for therapeutic development against cancer.
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Rapamycin Treatment for Benign Multicystic Peritoneal Mesothelioma: A Rare Disease with a Difficult Management.
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Rapid Communication: Prolactin and hydrocortisone impact TNF?-mediated mitogen-activated protein kinase signaling and inflammation of bovine mammary epithelial (MAC-T) cells.
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Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound.
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Rapid Somatic Mutation Testing in Colorectal Cancer by Use of a Fully Automated System and Single-Use Cartridge: A Comparison with Next-Generation Sequencing.
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Rare Germ Line CHEK2 Variants Identified in Breast Cancer Families Encode Proteins That Show Impaired Activation.
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Ras and Raf pathways in epidermis development and carcinogenesis.
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RAS Promotes Proliferation and Resistances to Apoptosis in Meningioma.
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RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
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Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells.
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Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation.
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RASSF1A-mediated regulation of AREG via the Hippo pathway in hepatocellular carcinoma.
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Re-expression of AKAP12 inhibits progression and metastasis potential of colorectal carcinoma in vivo and in vitro.
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Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting GSK-3?.
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Re: Takada Y, Sethi G, Sung B, and Aggarwal BB (2008) Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells Mol Pharmacol May 2008 73:1549-1557; doi:10.1124/mol.107.041350.
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Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation.
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Reactive oxygen species abrogate the anticarcinogenic effect of eicosapentaenoic acid in Atm-deficient mice.
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Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells.
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Real-Time PCR Cycle Threshold Values for the BRAFV600E Mutation in Papillary Thyroid Microcarcinoma May Be Associated With Central Lymph Node Metastasis: A Retrospective Study.
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Reassessing the role of C-MYB in tumorigenesis.
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Recent Developments of Small Molecule PI3K/mTOR Dual Inhibitors.
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Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications.
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Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.
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Recent updates in thoracic SMARCA4-deficient undifferentiated tumor.
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Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways.
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Receptor-Interacting Serine/Threonine-Protein Kinase-2 as a Potential Prognostic Factor in Colorectal Cancer.
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Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance.
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Recombinant human thrombopoietin combined with interleukin-2 improves the effects of chemosensitivity and thrombocytopenia on a basic gemcitabine and carboplatin combination therapy for non-small cell lung cancer in a nude mouse model.
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Recurrent inactivating mutations of ARID2 in non-small cell lung carcinoma.
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Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma.
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Recurrent small intestine intussusception in a patient with Peutz-Jeghers syndrome.
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REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer.
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Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma.
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Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.
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Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer.
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Reduced expression of Raf-1 kinase inhibitory protein in renal cell carcinoma: a significant prognostic marker.
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Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma.
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Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch.
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Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition.
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Reduced Raf-1 kinase inhibitor protein expression predicts less favorable outcomes in patients with hepatic colorectal metastasis.
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Reduced RKIP enhances nasopharyngeal carcinoma radioresistance by increasing ERK and AKT activity.
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Reduced RKIP Expression is Associated With Breast Neoplastic Progression and is Correlated With Poor Outcomes and Aberrant Methylation in Breast Carcinoma.
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Reduction of HLA-DR+ lymphocytes after treatment with enzastaurin in patients with metastatic thyroid cancer.
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Redundant and nonredundant functions of ATM and H2AX in ?? T-lineage lymphocytes.
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Regorafenib sensitizes human breast cancer cells to radiation by inhibiting multiple kinases and inducing DNA damage.
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Regulation and repurposing of nutrient sensing and autophagy in innate immunity.
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Regulation of AKT activity by inhibition of the pleckstrin homology domain-PtdIns(3,4,5)P3 interaction using flavonoids.
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Regulation of AKT Activity by Inhibition of the Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interaction Using Flavonoids.
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Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
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Regulation of beta-catenin by t-DARPP in Upper Gastrointestinal Cancer Cells.
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Regulation of c-Jun N-terminal kinase and p38 kinase pathways in endothelial cells.
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Regulation of c-Raf-1: therapeutic implications.
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Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.
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Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay.
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Regulation of cardiomyocyte full-length tissue factor expression and microparticle release under inflammatory conditions in vitro.
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Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7.
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Regulation of ERK3/MAPK6 expression by BRAF.
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Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
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Regulation of GADD153 induced by mechanical stress in cardiomyocytes.
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Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein.
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Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling.
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Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells.
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Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression.
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Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways.
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Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis.
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Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.
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Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer.
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Regulation of PKB/Akt-pathway in the chemopreventive effect of lactoferrin against diethylnitrosamine-induced hepatocarcinogenesis in rats.
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Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.
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Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway.
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Regulation of protein transport to the nucleus: central role of phosphorylation.
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Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling.
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Regulation of ribosomal protein S6 kinase in human mammary tumor cells: effect of estrogen, growth factors and phorbol ester.
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Regulation of ribosomal S6 protein kinase-p90(rsk), glycogen synthase kinase 3, and beta-catenin in early Xenopus development.
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Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer.
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Regulation of the C-X-C chemokine, mob-1, gene expression in primary rat hepatocytes.
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Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve.
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Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.
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Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity.
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Regulation of the human papillomavirus oncoproteins by differential phosphorylation.
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Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins.
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Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.
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Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.
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Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1.
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Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation.
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Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.
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Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2.
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Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.
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Relation between outcomes and localisation of p-mTOR expression in gastric cancer.
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Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
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Relationship between (18)F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma.
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Relationship between CD147 and expression of amino acid transporters (LAT1 and ASCT2) in patients with pancreatic cancer.
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Relationship between functional polymorphism in the Aurora A gene and susceptibility of hepatocellular carcinoma.
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Relationship between thyroid tumor radiosensitivity and nuclear localization of DNA-dependent protein kinase catalytic subunit.
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Relative bioavailability of a prototype oral solution of the Aurora A kinase inhibitor alisertib (MLN8237) in patients with advanced solid tumors.
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Relative frequency and morphology of cancers in STK11 mutation carriers.
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Relevance of STK11 Mutations Regarding Immune Cell Infiltration, Drug Sensitivity, and Cellular Processes in Lung Adenocarcinoma.
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Repair of radiation damage of U2OS osteosarcoma cells is related to DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity.
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Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence.
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Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors.
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Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
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Repressing the Activity of Protein Kinase CK2 Releases the Brakes on Mitochondria-Mediated Apoptosis in Cancer Cells.
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Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation.
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Requirement of epithelial integrin-linked kinase for facilitation of Citrobacter rodentium-induced colitis.
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Requirement of thyrotropin-dependent complex formation of protein kinase A catalytic subunit with inhibitor of {kappa}B proteins for activation of p65 nuclear factor-{kappa}B by tumor necrosis factor-{alpha}.
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Requirements for the destruction of human Aurora-A.
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Research on protective mechanism of ibuprofen in myocardial ischemia-reperfusion injury in rats through the PI3K/Akt/mTOR signaling pathway.
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Research Progress of 70 kDa Ribosomal Protein S6 Kinase (P70S6K) Inhibitors as Effective Therapeutic Tools for Obesity, Type II Diabetes and Cancer.
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Resistance to durvalumab and durvalumab plus tremelimumab is associated with functional STK11 mutations in non-small-cell lung cancer patients and is reversed by STAT3 knockdown.
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Resistance to targeted therapy in renal-cell carcinoma.
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Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis.
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Response of cancer cells to molecular interruption of the CK2 signal.
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Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin.
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Restoring Ikaros's wings to solve a leukemia maze.
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Results of a phase I trial of sorafenib (BAY 43-9006) in combination with oxaliplatin in patients with refractory solid tumors, including colorectal cancer.
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Results of phase I pharmacokinetic and pharmacodynamic studies of the Raf kinase inhibitor BAY 43-9006 in patients with solid tumors.
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Resveratrol activates DNA damage response through inhibition of polo-like kinase 1 (PLK1) in natural killer/T cell lymphoma.
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Resveratrol binds and activates RKIP protein in colorectal cancer.
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Resveratrol Enhances Inhibition Effects of Cisplatin on Cell Migration and Invasion and Tumor Growth in Breast Cancer MDA-MB-231 Cell Models In Vivo and In Vitro.
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Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways.
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Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway.
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Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235.
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Retroviral gene transfer of dominant negative raf-1 mutants suppresses ha-ras-induced transformation and delays tumor formation.
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Revealing synergistic mechanism of multiple components in Stauntonia brachyanthera Hand.-Mazz. for gout by virtual screening and system pharmacological approach.
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Revealing the BRD4-NOTCH3 fusion: A novel hill in the cancer landscape.
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Reversal of Cancer Multidrug Resistance (MDR) Mediated by ATP-Binding Cassette Transporter G2 (ABCG2) by AZ-628, a RAF Kinase Inhibitor.
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Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
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Reversible and phorbol ester-specific defect of protein kinase C translocation in hepatocytes isolated from phenobarbital-treated rats.
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Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown.
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Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells.
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Review of genetic and epigenetic alterations in hepatocarcinogenesis.
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Revisiting mTOR inhibitors as anticancer agents.
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Revisiting p53 for cancer-specific chemo- and radiotherapy: Ten years after.
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RHAMM, p21 combined phenotype identifies microsatellite instability-high colorectal cancers with a highly adverse prognosis.
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Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.
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Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
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Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila.
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RhoC and ROCKs regulate cancer cell interactions with endothelial cells.
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RIalpha Influences Cellular Proliferation in Cancer Cells by Transporting RFC40 into the Nucleus.
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Ribonucleotide reductase R2 gene expression and changes in drug sensitivity and genome stability.
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Ribosomal protein S6 kinase and PKC in human mammary tumor cells.
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Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.
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Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs.
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Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-?B Pathway.
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Rice WNK1 is regulated by abiotic stress and involved in internal circadian rhythm.
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RIP2 is a Raf1-activated mitogen-activated protein kinase kinase.
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RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation.
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RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis.
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RIPK1-mediated immunogenic cell death promotes anti-tumour immunity against soft-tissue sarcoma.
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RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma.
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RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis.
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RIPK4 promoted the tumorigenicity of nasopharyngeal carcinoma cells.
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RIPK4 Suppresses the Invasion and Metastasis of Hepatocellular Carcinoma by Inhibiting the Phosphorylation of STAT3.
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Risk factors for pancreatic ductal adenocarcinoma specifically stimulate pancreatic duct glands in mice.
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RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and anti-tumor activities in breast cancer.
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RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
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RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer.
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RKIP expression of liver and kidney after arsenic exposure.
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RKIP Inhibition in Cervical Cancer Is Associated with Higher Tumor Aggressive Behavior and Resistance to Cisplatin Therapy.
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RKIp inhibits the migration and invasion of human prostate cancer PC-3M cells through regulation of extracellular matrix.
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RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients.
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RKIP Regulates Differentiation-Related Features in Melanocytic Cells.
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RKIP suppresses the proliferation and metastasis of breast cancer cell lines through up-regulation of miR-185 targeting HMGA2.
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RKTG overexpression inhibits proliferation and induces apoptosis of human leukemia cells via suppression of the ERK and PI3K/AKT signaling pathways.
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RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells.
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RNA interference (RNAi) mediated stable knockdown of protein casein kinase 2-alpha (CK2?) inhibits migration and invasion and enhances cisplatin-induced apoptosis in HEp-2 laryngeal carcinoma cells.
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RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.
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RNA Interference-Mediated Aurora Kinase A Gene Silencing Inhibits Human Glioma Cells Proliferation and Tumor Growth in Mice.
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RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug.
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RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors.
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RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer.
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RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer.
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RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
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RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells.
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RO3280, A Novel PLK1 Inhibitor, Suppressed Proliferation of MCF-7 Breast Cancer Cells Through Induction of Cell Cycle Arrest at G2/M Point.
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ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
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ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.
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ROCK1 and LIMK2 interact in spread but not blebbing cancer cells.
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ROCK1 and ROCK2 Are Down-regulated in Aggressive and Advanced Skin Melanomas - A Clinicopathological Perspective.
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ROCK1 and ROCK2 are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion.
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ROCK1 as a potential therapeutic target in osteosarcoma.
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ROCK1 feedback regulation of the upstream small GTPase RhoA.
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ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating the LATS2-JNK signaling pathway.
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ROCK1 promotes migration and invasion of non?small?cell lung cancer cells through the PTEN/PI3K/FAK pathway.
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ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.
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Rock2 promotes RCC proliferation by decreasing SCARA5 expression through ?-catenin/TCF4 signaling.
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Rock2 stabilizes ?-catenin to promote tumor invasion and metastasis in colorectal cancer.
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Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3?-mediated oxidative stress and IRE1?/TRAF2/JNK pathway.
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Role for p53 in selenium-induced senescence.
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Role of a novel race-related tumor suppressor microRNA located in frequently deleted chromosomal locus 8p21 in prostate cancer progression.
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Role of A-Kinase anchor protein (AKAP4) in growth and survival of ovarian cancer cells.
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Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons.
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Role of ATP synthase alpha subunit in low-dose endothelial monocyte-activating polypeptide-II-induced opening of the blood-tumor barrier.
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Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.
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Role of cAMP-Dependent Protein Kinase A Activity in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood-Tumor Barrier.
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Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.
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Role of CK2 inhibitor CX-4945 in anti-cancer combination therapy - potential clinical relevance.
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Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment.
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Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action.
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Role of extracellular electrolytes in the activation of ribosomal protein S6 kinase by epidermal growth factor, insulin-like growth factor 1, and insulin in ZR-75-1 cells.
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Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.
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Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways.
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Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions.
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Role of glycogen synthase kinase-3? inhibitor AZD1080 in ovarian cancer.
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Role of HIPK2 in kidney fibrosis.
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Role of Human papilloma virus Infection and Altered Methylation of Specific Genes in Esophageal Cancer.
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Role of hypermethylation of DAP-kinase CpG island in the development of thyroid lymphoma.
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Role of MAP kinase pathways in primitive neuroectodermal tumors.
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Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies.
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Role of nuclear bodies in apoptosis signalling.
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Role of p21 in SP600125-induced cell cycle arrest, endoreduplication, and apoptosis.
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Role of p53 Up-regulated Modulator of Apoptosis and Phosphorylated Akt in Melanoma Cell Growth, Apoptosis, and Patient Survival.
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Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival.
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Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer.
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Role of protein kinase CK2 in the regulation of tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis in prostate cancer cells.
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Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.
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Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
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Role of Raf-kinase inhibitor protein in colorectal cancer and its regulation by hydroxycamptothecine.
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Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements.
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Role of receptor-interacting protein in tumor necrosis factor-alpha -dependent MEKK1 activation.
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Role of RHAMM within the hierarchy of well-established prognostic factors in colorectal cancer.
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Role of serine 365 in BRAF V600E sensitivity to RAF inhibition.
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Role of serine/threonine kinase 33 methylation in colorectal cancer and its clinical significance.
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Role of sunitinib and sorafenib in the treatment of metastatic renal cell carcinoma.
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Role of the beta isoform of 14-3-3 proteins in cellular proliferation and oncogenic transformation.
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Role of the JNK pathway on the expression of inflammatory factors in alveolar macrophages under mechanical ventilation.
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Role of the PI3K/Akt, mTOR, and STK11/LKB1 pathways in the tumorigenesis of sclerosing hemangioma of the lung.
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Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin.
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Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.
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Roles of BRCA1 and its interacting proteins.
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Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases.
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Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells.
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Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells.
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Roles of low-density lipoprotein receptor-related protein 1 in tumors.
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ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.
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ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cells.
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Rotenone could activate microglia through NF?B associated pathway.
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RP1 is a phosphorylation target of CK2 and is involved in cell adhesion.
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RSK activation via ERK modulates human colon cancer cells response to PTHrP.
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RSK in tumorigenesis: connections to steroid signaling.
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RSK-mediated down-regulation of PDCD4 is required for proliferation, survival, and migration in a model of triple-negative breast cancer.
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RSK2 Binding Models Delineate Key Features for Activity.
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RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis.
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RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma.
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RSK4: a new prognostic factor in glioma.
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S-nitrosylation of PTEN Invovled in Ischemic Brain Injury in Rat Hippocampal CA1 Region.
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S6 Kinase 2 Promotes Breast Cancer Cell Survival via Akt.
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Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors.
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Safety and preliminary efficacy data of a novel Casein Kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies.
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Safety, tolerability and antitumour activity of LY2780301 (p70S6K/AKT inhibitor) in combination with gemcitabine in molecularly selected patients with advanced or metastatic cancer: a phase IB dose escalation study.
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Saikosaponin a protects TBI rats after controlled cortical impact and the underlying mechanism.
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Salicylaldehyde derivatives as new protein kinase CK2 inhibitors.
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Salicylate inhibition of extracellular signal-regulated kinases and inducible nitric oxide synthase.
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Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3? Signaling.
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Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient.
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Science Signaling Podcast for 15 November 2016: A new type of kinase inhibitor.
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Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer.
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Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice.
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Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo.
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SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest.
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Search for Potent and Selective Aurora A Inhibitors Based on General Ser/Thr Kinase Pharmacophore Model.
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Secoisolariciresinol Diglucoside Exerts Anti-Inflammatory and Antiapoptotic Effects through Inhibiting the Akt/I?B/NF-?B Pathway on Human Umbilical Vein Endothelial Cells.
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Secretome analysis of ionizing radiation-induced senescent cancer cells reveals that secreted RKIP plays a critical role in neighboring cell migration.
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Selective Biligand Inhibitor of CK2 Increases Caspase-3 Activity in Cancerous Cells and Inhibits Platelet Aggregation.
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Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.
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Selective CRAF Inhibition Elicits Transactivation.
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Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death.
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Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity.
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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.
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Selective expression and immunogenicity of the cancer/testis antigens SP17, AKAP4 and PTTG1 in non-small cell lung cancer: new candidates for active immunotherapy.
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Selective growth inhibition by glycogen synthase kinase-3 inhibitors in tumorigenic HeLa hybrid cells is mediated through NF-?B-dependent GLUT3 expression.
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Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.
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Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.
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Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.
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Selective Oral MEK1/2 Inhibitor Pimasertib in Metastatic Melanoma: Antitumor Activity in a Phase I, Dose-Escalation Trial.
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Selective Raf inhibition in cancer therapy.
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Selective Regulation of B-Raf Dependent K-Ras/Mitogen-Activated Protein by Natural Occurring Multi-kinase Inhibitors in Cancer Cells.
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Selective targeting of checkpoint kinase 1 in tumor cells with a novel potent oncolytic adenovirus.
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Semaphoring mAb: a New Guide in RIT in Inhibiting the Proliferation of Human Skin Carcinoma.
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Semisynthesis and biological evaluation of a cotylenin A mimic derived from fusicoccin A.
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Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.
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Sensitization of tumor cells to Apo2 ligand/TRAIL-induced apoptosis by inhibition of casein kinase II.
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Sequence analysis of the PRKAR1A gene in sporadic somatotroph and other pituitary tumours.
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Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer.
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Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis.
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Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines.
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Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5? Promotes Cancer Invasion and Tumor Growth.
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Serine/Threonine Kinase 11 Plays a Canonical Role in Malignant Progression of KRAS-mutant and GNAS-wild-type Intraductal Papillary Mucinous Neoplasms of the Pancreas.
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Serine/threonine kinase 15 gene polymorphism and risk of digestive system cancers: A meta-analysis.
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Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination.
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Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression.
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Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.
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Serine/threonine kinase BUB1 promotes proliferation and radio-resistance in glioblastoma.
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Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma.
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Serine/Threonine Kinase Pim-2 Promotes Liver Tumorigenesis Induction Through Mediating Survival and Preventing Apoptosis of Liver Cell.
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Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells.
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Sertoli Leydig cell ovarian tumour and gastric polyps as presenting features of Peutz-Jeghers syndrome.
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Serum and glucocorticoid-regulated kinase 1 (SGK1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with SGK1 inhibitor and ?-ray irradiation was elucidated.
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Serum pyruvate dehydrogenase kinase as a prognostic marker for cholangiocarcinoma.
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Serum tumor markers for the prediction of concordance between genomic profiles from liquid and tissue biopsy in patients with advanced lung adenocarcinoma.
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SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis.
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Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions.
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Sex-determining region Y-related high mobility group box (SOX)-2 is overexpressed in cervical squamous cell carcinoma and contributes cervical cancer cell migration and invasion in vitro.
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SH3RF2 functions as an oncogene by mediating PAK4 protein stability.
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Shear Stress-Dependent Downregulation of the Adhesion-G Protein-Coupled Receptor CD97 on Circulating Leukocytes upon Contact with Its Ligand CD55.
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Shedding of tyrosine and serine/threonine ecto-protein kinases from human leukemic cells.
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ShenLingLan Influences the Attachment and Migration of Ovarian Cancer Cells Potentially through the GSK3 Pathway.
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Shikonin inhibits migration and invasion of triple-negative breast cancer cells by suppressing epithelial-mesenchymal transition via miR-17-5p/PTEN/Akt pathway.
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Shilianhua extract inhibits GSK-3{beta} and promotes glucose metabolism.
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Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers.
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Short-term culturing of low-grade superficial bladder transitional cell carcinomas leads to changes in the expression levels of several proteins involved in key cellular activities.
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Short-term therapy with peroxisome proliferation-activator receptor-alpha agonist Wy-14,643 protects murine fatty liver against ischemia-reperfusion injury.
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Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.
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ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer.
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Sichuan Pepper Extracts Block the PAK1/Cyclin D1 Pathway and the Growth of NF1-Deficient Cancer Xenograft in Mice.
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Signal Therapy of NF1-Deficient Tumor Xenograft in Mice by the Anti-PAK1 Drug FK228.
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Signal transduction events in mammalian cells in response to ionizing radiation.
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Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.
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Signaling and drug sensitivity.
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Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis.
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Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction.
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Signaling from the Golgi: mechanisms and models for Golgi phosphoprotein 3-mediated oncogenesis.
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Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin.
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Signaling pathways in adenoid cystic cancers: Implications for treatment.
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Signaling pathways in adrenocortical cancer.
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Signaling through Raf-1 in the neovasculature and target validation by nanoparticles.
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Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment.
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Significance of protein kinase CK2 nuclear signaling in neoplasia.
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Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer.
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Silencing ARAF Suppresses the Malignant Phenotypes of Gallbladder Cancer Cells.
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Silencing c-Jun inhibits autophagy and abrogates radioresistance in nasopharyngeal carcinoma by activating the PI3K/AKT/mTOR pathway.
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Silencing CDCA8 Suppresses Hepatocellular Carcinoma Growth and Stemness via Restoration of ATF3 Tumor Suppressor and Inactivation of AKT/?-Catenin Signaling.
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Silencing of 14-3-3? over-expression in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium.
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Silencing of A-Kinase Anchor Protein 4 (AKAP4) Inhibits Proliferation and Progression of Thyroid Cancer.
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Silencing of Aurora kinase A by RNA interference inhibits tumor growth in human osteosarcoma cells by inducing apoptosis and G2/M cell cycle arrest.
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Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells.
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Silencing of DNA-PKcs alters the transcriptional profile of certain signal transduction genes related to proliferation and differentiation in HeLa cells.
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Silencing of RIPK4 inhibits epithelial?mesenchymal transition by inactivating the Wnt/??catenin signaling pathway in osteosarcoma.
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Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1).
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Silencing the long noncoding RNA NORAD inhibits gastric cancer cell proliferation and invasion by the RhoA/ROCK1 pathway.
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Silencing UHRF1 Enhances Radiosensitivity of Esophageal Squamous Cell Carcinoma by Inhibiting the PI3K/Akt/mTOR Signaling Pathway.
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Silibinin Inhibits Tumor Growth through Downregulation of Extracellular Signal-Regulated Kinase and Akt in Vitro and in Vivo in Human Ovarian Cancer Cells.
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Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.
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Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme.
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Single amino acid substitutions in "low-risk" human papillomavirus (HPV) type 6 E7 protein enhance features characteristic of the "high-risk" HPV E7 oncoproteins.
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Single cell network profiling assay in bladder cancer.
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Single-Dose Neoadjuvant AKT Pathway Inhibitor Reduces Growth of Hepatocellular Carcinoma after Laser Thermal Ablation in Small-Animal Model.
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Single-nucleotide polymorphisms of TGF?1 and ATM associated with radiation-induced pneumonitis: a prospective cohort study of thoracic cancer patients in China.
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SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.
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SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
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Site-specific activation of AKT protects cells from death induced by glucose deprivation.
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Skp2-mediated ubiquitination and mitochondrial localization of Akt drive tumor growth and chemoresistance to cisplatin.
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SMAD4 suppresses AURKA-induced metastatic phenotypes via degradation of AURKA in a TGF?-independent manner.
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Small interfering RNA targeting integrin-linked kinase inhibited the growth and induced apoptosis in human bladder cancer cells.
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Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo.
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Small Molecule Inhibition of Glycogen Synthase Kinase-3 in Cancer Immunotherapy.
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Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
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Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways.
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Small molecules modulation of 14-3-3 protein-protein interactions.
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Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton.
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Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models.
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Small-molecule modulation of p53 protein-protein interactions.
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Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
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SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling.
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SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways.
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Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways.
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SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.
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Snail heterogeneity in clear cell renal cell carcinoma.
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Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions.
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Sodium selenite increases the activity of the tumor suppressor protein, PTEN, in DU-145 prostate cancer cells.
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Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.
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Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.
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Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.
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Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.
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Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.
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Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome.
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Somatic STK11 and Concomitant STK11/KRAS Mutational Frequency in Stage IV Lung Adenocarcinoma Adrenal Metastases.
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Sorafenib enhances the antitumor effects of chemoradiation treatment by downregulating ERCC-1 and XRCC-1 DNA repair proteins.
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Sorafenib-associated remission of psoriasis in hypernephroma: case report.
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Sorafenib: a review of its use in advanced hepatocellular carcinoma.
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Sotorasib for Lung Cancers with KRAS p.G12C Mutation.
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Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice.
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SP600125 overcomes antimitotic drug-resistance in cancer cells by increasing apoptosis with independence of P-gp inhibition.
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Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth.
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Specific overexpression of cyclin E·CDK2 in early preinvasive and primary breast tumors in female ACI rats induced by estrogen.
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Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.
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Specific up-regulation of CRH or AVP secretion by acetylcholine or lipopolysaccharide in inflammatory susceptible Lewis rat fetal hypothalamic cells.
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Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.
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SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma.
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Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs.
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Spillover of cytokines and reactive oxygen species in ventilator-induced lung injury associated with inflammation and apoptosis in distal organs.
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Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity.
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Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours.
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Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection.
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Sporadic medulloblastomas contain oncogenic beta-catenin mutations.
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Spotlight on AKT: Current Therapeutic Challenges.
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Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization.
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Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation.
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Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin.
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Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila.
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SRPK2 promotes the growth and migration of the colon cancer cells.
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Stability of phosphoprotein as a biological marker of tumor signaling.
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Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye's Stress Coping Response: Progress, Achievements, and the Future.
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Stable knockdown of protein kinase CK2-alpha (CK2?) inhibits migration and invasion and induces inactivation of hedgehog signaling pathway in hepatocellular carcinoma Hep G2 cells.
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STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.
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State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261.
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Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling.
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Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma.
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Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents.
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Staurosporine stimulates expression of the urokinase-type (u-PA) plasminogen activator in LLC-PK1 cells.
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Stem Cell-Like Properties of CK2?-down Regulated Mammary Cells.
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Stephania Tetrandra and Ginseng-Containing Chinese Herbal Formulation NSENL Reverses Cisplatin Resistance in Lung Cancer Xenografts.
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Stereospecific antitumor activity of radicicol oxime derivatives.
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Steroidogenic acute regulatory protein mRNA expression in adrenal tumours.
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Stimulation of the Na(+)-coupled glucose transporter SGLT1 by B-RAF.
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STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype.
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STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation.
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STK11 alterations in the pan-cancer setting: prognostic and therapeutic implications.
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STK11 Domain XI Mutations: Candidate Genetic Drivers Leading to the Development of Dysplastic Polyps in Peutz-Jeghers Syndrome.
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STK11 genotyping and cancer risk in Peutz-Jeghers syndrome.
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STK11 is required for the normal program of ciliated cell differentiation in airways.
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STK11 loss drives rapid progression in a breast cancer patient resulting in pulmonary tumor thrombotic microangiopathy.
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STK11 mutation status is associated with decreased survival in meningiomas.
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STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.
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STK11 p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors.
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STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary-Mucinous Carcinoma of the Transverse Colon.
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STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.
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STK15 rs2273535 polymorphism and cancer risk: A meta-analysis of 74,896 subjects.
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STK17B promotes the progression of ovarian cancer.
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STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer.
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STK31 Maintains the Undifferentiated State of Colon Cancer Cells.
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STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells.
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STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.
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STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1?/VEGF signaling pathway.
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STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential.
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STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
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STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1?.
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STK33 promotes hepatocellular carcinoma through binding to c-Myc.
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STK33 promotes the growth and progression of human pancreatic neuroendocrine tumour via activation of the PI3K/AKT/mTOR pathway.
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STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer.
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STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma.
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STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes.
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STK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma.
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STK39, overexpressed in osteosarcoma, regulates osteosarcoma cell invasion and proliferation.
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STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
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Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.
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Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis.
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Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity.
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Structural analysis of fungal pathogenicity-related casein kinase ? subunit, Cka1, in the human fungal pathogen Cryptococcus neoformans.
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Structural and functional studies of protein kinase C.
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Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2.
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Structural Basis for Low-Affinity Binding of Non-R2 Carboxylate-Substituted Tricyclic Quinoline Analogs to CK2?: Comparative Molecular Dynamics Simulation Studies.
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Structural basis for the activity of the RSK-specific inhibitor, SL0101.
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Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins.
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Structural basis of the constitutive activity of protein kinase CK2.
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Structural Characterization of the Aurora Kinase B "DFG-flip" Using Metadynamics.
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Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors.
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Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms.
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Structural Determinants of CX-4945 Derivatives as Protein Kinase CK2 Inhibitors: A Computational Study.
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Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization.
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Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.
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Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
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Structural insights into mis-regulation of protein kinase A in human tumors.
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Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR.
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Structure and enzymology of a death-associated protein kinase.
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Structure and regulation of the human Nek2 centrosomal kinase.
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Structure meets function--centrosomes, genome maintenance and the DNA damage response.
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Structure of a Moloney murine leukemia virus-virus-like 30 recombinant: implications for transduction of the c-Ha-ras proto-oncogene.
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Structure of protein kinase CK2: dimerization of the human beta-subunit.
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Structure of the complex of phosphorylated liver kinase B1 and 14-3-3?.
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Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer.
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Structure, function, involvement in diseases and targeting of 14-3-3 proteins: an update.
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Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3? inhibitors: A critical review.
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Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.
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Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.
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Structure-based approaches in the design of GSK-3 selective inhibitors.
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Structure-based CoMFA and CoMSIA study of indolinone inhibitors of PDK1.
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Structure-based design of small molecule and peptide inhibitors for selective targeting of ROCK1: an integrative computational approach.
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Structure-based discovery of new maternal embryonic leucine zipper kinase inhibitors.
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Structure-Based Discovery of Novel CK2?-Binding Cyclic Peptides with Anti-Cancer Activity.
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Structure-based discovery of small molecules targeting different surfaces of protein-kinase CK2.
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Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors.
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Structure-based grafting and identification of kinase-inhibitors to target mTOR signaling pathway as potential therapeutics for glioblastoma.
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Structure-based identification of novel CK2 inhibitors with a linear 2-propenone scaffold as anti-cancer agents.
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Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
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Studies of perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts.
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Study on correlation between PKIB and pAkt expression in breast cancer tissues.
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Study on Inhibitory Effect of MaiMenDong Decoction and WeiJing Decoction Combination with Cisplatin on NCI-A549 Xenograft in Nude Mice and Its Mechanism.
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STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.
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STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.
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STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.
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STYK1 promotes Warburg effect through PI3K/AKT signaling and predicts a poor prognosis in nasopharyngeal carcinoma.
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STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma.
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Subcellular immunolocalization of protein kinase CK2 in normal and carcinoma cells.
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Subcellular localization of the spindle proteins Aurora A, Mad2, and BUBR1 assessed by immunohistochemistry.
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Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study.
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Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed.
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Sulfur and nitrogen-containing compounds from the whole bodies of Blaps japanensis.
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Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells.
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Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells.
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Suppression Of ?-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma.
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Suppression of a human colon cancer cell line by introduction of an exogenous NF1 gene.
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Suppression of AKT expression by miR-153 produced anti-tumor activity in lung cancer.
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Suppression of Aurora-A Oncogenic Potential by c-Myc Downregulation.
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Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis.
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Suppression of casein kinase 2 sensitizes tumor cells to antitumor TRAIL therapy by regulating the phosphorylation and localization of p65 in prostate cancer.
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Suppression of CDK2 expression by siRNA induces cell cycle arrest and cell proliferation inhibition in human cancer cells.
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Suppression of DNA-dependent protein kinase sensitize cells to radiation without affecting DSB repair.
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Suppression of glycogen synthase kinase 3 activity reduces tumor growth of prostate cancer in vivo.
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Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer.
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Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling.
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Suppression of lung cancer cell invasion by LKB1 is due to the downregulation of tissue factor and vascular endothelial growth factor, partly dependent on SP1.
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Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes.
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Suppression of migratory and metastatic pathways via blocking VEGFR1 and VEGFR2.
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Suppression of multiple processes relevant to cancer progression by benzyl isothiocyanate may result from the inhibition of Aurora A kinase activity.
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Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone.
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Suppression of the Antigen-Stimulated RBL-2H3 Mast Cell Activation by Artekeiskeanol A.
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Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling.
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Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone.
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Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.
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Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse.
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Surface-Modified HK:siRNA Nanoplexes with Enhanced Pharmacokinetics and Tumor Growth Inhibition.
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Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis.
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Survey of Raf kinase inhibitor protein (RKIP) in multiple cancer types.
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Survival analysis in Caucasian pulmonary adenocarcinoma patients based on differential targets between Caucasian and Asian population.
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Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression.
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SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequence.
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Switching of Self-Assembly in a Peptide Nanostructure with a Specific Enzyme.
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Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways.
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Switching on kinases: oncogenic activation of BRAF and the PDGFR family.
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Synergistic B cell activation by CD40 and the B cell antigen receptor: role of B lymphocyte antigen receptor-mediated kinase activation and tumor necrosis factor receptor-associated factor regulation.
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Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models.
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Synergistic enhancement of NK cell-mediated cytotoxicity by combination of histone deacetylase inhibitor and ionizing radiation.
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Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotide targeting protein kinase A.
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Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation.
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Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models.
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Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma.
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Synergistic targeting of CHK1 and mTOR in MYC-driven tumors.
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Synergy between tumor necrosis factor alpha and interleukin 1beta in inducing transcriptional down-regulation of muscarinic M2 receptor gene expression. Involvement of protein kinase A and ceramide pathways.
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Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.
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Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives.
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Synthesis and biological activity of Akt/PI3K inhibitors.
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Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases.
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Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells.
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Synthesis and biological evaluation of 2,6-di(furan-3-yl)anthracene-9, 10-dione as an inhibitor of human protein kinase CK2.
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Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstitued-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d]pyrimidine analogues as novel CHK1 inhibitors.
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Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions.
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Synthesis and biological evaluation of novel 2 (4`-hydroxynaphthyl) chromen-4-one as a CK2 inhibitor.
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Synthesis and biological evaluation of novel 5,6-dihydropyrimido[4,5-f]quinazoline derivatives as potent CDK2 inhibitors.
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Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2.
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Synthesis and Docking Analysis of New Heterocyclic System N(1), N(4)-bis (2-chloroquinolin-3-yl) methylene) benzene-1, 4-diamine as Potential Human AKT1 Inhibitor.
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Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors.
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Synthesis and quantum chemical studies of new 4-aminoquinazoline derivatives as Aurora A/B kinase inhibitors.
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Synthesis and SAR of inhibitors of protein kinase CK2: novel tricyclic quinoline analogs.
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Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
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Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors.
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Synthesis and structure-activity relationship studies of peptidomimetic PKB/Akt inhibitors: the significance of backbone interactions.
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Synthesis of Cis-Fused Pyran Indolocarbazole Derivatives that Inhibit FLT3 Kinase and the DNA Damage Kinase, Checkpoint Kinase 1.
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Synthesis of Coumarin Derivatives as Versatile Scaffolds for GSK-3? Enzyme Inhibition.
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Synthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells.
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Synthesis of pyrimidin-4-one-1,2,3-triazole conjugates as glycogen synthase kinase-3? inhibitors with anti-depressant activity.
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Synthesis, biological evaluation and 3D-QSAR study of novel 4,5-dihydro-1H-pyrazole thiazole derivatives as BRAF(V???E) inhibitors.
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Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.
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Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.
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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.
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Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy.
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Synthetic lethality interaction between Aurora kinases and CHEK1 inhibitors in ovarian cancer.
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Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer.
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Systematic CpG Islands Methylation Profiling of Genes in the Wnt Pathway in Epithelial Ovarian Cancer Identifies Biomarkers of Progression-Free Survival.
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Systematic module approach identifies altered genes and pathways in four types of ovarian cancer.
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Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library.
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Systemic delivery and pre-clinical evaluation of nanoparticles containing antisense oligonucleotides and siRNAs.
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Systemic delivery of HK Raf-1 siRNA polyplexes inhibits MDA-MB-435 xenografts.
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Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer.
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Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines.
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T-Cell Mutation Leads to GI Polyps.
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T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23).
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T-cell prolymphocytic leukemia with der(11)t(1;11)(q21;q23) and ATM deficiency.
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T7 Peptide-Conjugated Lipid Nanoparticles for Dual Modulation of Bcl-2 and Akt-1 in Lung and Cervical Carcinomas.
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T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions.
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TACC1-chTOG-Aurora A protein complex in breast cancer.
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TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.
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TAK1, more than just innate immunity.
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TAK1-mediated stress signaling pathways are essential for TNF-alpha-promoted pulmonary metastasis of murine colon cancer cells.
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Take your PIKK: tumour viruses and DNA damage response pathways.
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Talin2 regulates invasion of human breast cancer MDA-MB-231 cells via alteration of the tumor microenvironment.
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Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo.
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Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library.
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Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
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Targeted degradation of beta-catenin by chimeric F-box fusion proteins.
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Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.
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Targeted delivery of mutant Raf kinase to neovessels causes tumor regression.
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Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality.
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Targeted inhibition of mTOR signaling improves sensitivity of esophageal squamous cell carcinoma cells to cisplatin.
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Targeted knockdown of death-associated protein kinase expression induces TRAIL-mediated apoptosis in human endometrial adenocarcinoma cells.
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Targeted proteomic analysis of 14-3-3 sigma in nasopharyngeal carcinoma.
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Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
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Targeted restoration of down-regulated DAPK2 tumor suppressor activity induces apoptosis in Hodgkin lymphoma cells.
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Targeted small-molecule inhibitors of protein kinase B as anticancer agents.
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Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice.
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Targeting 14-3-3?-CDC25A interactions to trigger apoptotic cell death in skin cancer.
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Targeting 14-3-3zeta in cancer therapy.
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Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
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Targeting Akt in cancer for precision therapy.
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Targeting Akt in cancer therapy.
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Targeting Akt in cell transfer immunotherapy for cancer.
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Targeting AKT signaling sensitizes cancer to cellular immunotherapy.
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Targeting astrocyte signaling for chronic pain.
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Targeting breast cancer stem-like cells using chloroquine encapsulated by a triphenylphosphonium-functionalized hyperbranched polymer.
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Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel.
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Targeting Casein Kinase 1 (CK1) in Hematological Cancers.
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Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.
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Targeting CDC7 improves sensitivity to chemotherapy of esophageal squamous cell carcinoma.
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Targeting cell cycle kinases for cancer therapy.
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Targeting cell division cycle 7 kinase: a new approach for cancer therapy.
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Targeting chaperones in transformed systems--a focus on Hsp90 and cancer.
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Targeting checkpoint kinase 1 in cancer therapeutics.
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Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.
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Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.
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Targeting cyclin-dependent kinase 6 by vanillin inhibits proliferation of breast and lung cancer cells: Combined computational and biochemical studies.
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Targeting Delivery of Oligodeoxynucleotides to Macrophages by Mannosylated Cationic Albumin for Immune Stimulation in Cancer Treatment.
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Targeting disease through novel pathways of apoptosis and autophagy.
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Targeting dna double strand break repair with hyperthermia and dna-pkcs inhibition to enhance the effect of radiation treatment.
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Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation.
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Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells.
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Targeting ganglioneuromas with mTOR inhibitors.
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Targeting GSK-3: a promising approach for cancer therapy?
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Targeting GSK3 and Associated Signaling Pathways Involved in Cancer.
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Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling.
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Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.
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Targeting LIMK1 with luteolin inhibits the growth of lung cancer in vitro and in vivo.
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Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells.
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Targeting LKB1 in cancer - exposing and exploiting vulnerabilities.
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Targeting mammalian serine/threonine-protein kinase 4 through Yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis.
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Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.
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Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors.
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Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/?-catenin signaling pathway in cervical cancer.
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Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells.
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Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.
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Targeting of Protein Kinase CK2 in Acute Myeloid Leukemia Cells Using the Clinical-Grade Synthetic-Peptide CIGB-300.
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Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.
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Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.
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Targeting PDK1 in cancer.
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Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.
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Targeting protein kinase A in cancer therapy: an update.
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Targeting Protein Kinase CK2: Evaluating CX-4945 Potential for GL261 Glioblastoma Therapy in Immunocompetent Mice.
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Targeting Raf Kinase Inhibitory Protein Regulation and Function.
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Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.
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Targeting ROCK2 rather than ROCK1 inhibits Ewing sarcoma malignancy.
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Targeting serine/threonine protein kinase B/Akt and cell-cycle checkpoint kinases for treating cancer.
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Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo.
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Targeting the AKT protein kinase for cancer chemoprevention.
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Targeting the AKT/GSK3?/cyclin D1/Cdk4 Survival Signaling Pathway for Eradication of Tumor Radioresistance Acquired by Fractionated Radiotherapy.
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Targeting the Ataxia Telangiectasia Mutated protein in cancer therapy.
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Targeting the heparin-binding epidermal growth factor-like growth factor in ovarian cancer therapy.
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Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
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Targeting the LKB1 tumor suppressor.
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Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies.
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Targeting the Regulatory Subunit R2Alpha of Protein Kinase A in Human Glioblastoma through shRNA-Expressing Lentiviral Vectors.
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Targeting the RhoGTPase/ROCK pathway for the treatment of VHL/HIF pathway-driven cancers.
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Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy.
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Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta.
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Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway.
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TC003132 is essential for the follicle stem cell lineage in telotrophic Tribolium oogenesis.
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TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway.
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Teasing out the best molecular marker in the AKT/mTOR pathway in head and neck squamous cell cancer patients.
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Technology evaluation: GEM-231, Hybridon Inc.
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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
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Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells.
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Tenascin-C signaling through induction of 14-3-3 tau.
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Terpenoids from Abies holophylla Attenuate LPS-Induced Neuroinflammation in Microglial Cells by Suppressing the JNK-Related Signaling Pathway.
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TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability.
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TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer.
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Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors.
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Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines.
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TF - A novel cell-permeable and selective inhibitor of human protein kinase CK2 induces apoptosis in the prostate cancer cell line LNCaP.
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TFE3 regulates renal adenocarcinoma cell proliferation via activation of the mTOR pathway.
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TGF-ss inactivation and TGF-alpha overexpression cooperate in an in vivo mouse model to induce hepatocellular carcinoma that recapitulates molecular features of human liver cancer.
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Th e role of CDK12 in tumor bio logy.
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The 14-3-3 cancer connection.
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The 14-3-3 gene par-5 is required for germline development and DNA damage response in Caenorhabditis elegans.
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The 14-3-3 protein as the antigen for lung cancer-associated human monoclonal antibody AE6F4.
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The 14-3-3 proteins in regulation of cellular metabolism.
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The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development.
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The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site.
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The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins.
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The ?-catenin destruction complex.
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The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats.
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The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis.
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The action of phorbol ester on steroidogenesis in cultured human fetal adrenal cells.
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The activation of Akt during preoperative chemotherapy for esophageal cancer correlates with poor prognosis.
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The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers--a study of the National Cancer Institute of Canada Clinical Trials Group.
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The Akt of translational control.
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The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP.
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The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome.
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The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho-Ser-621 in the C terminus of CRAF.
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The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis.
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3?Y216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neurons.
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The antiapoptotic protein ICBP90 is a target for protein kinase 2.
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The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives.
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The antiresoptive effects of recombinant Lingzhi-8 protein against retinoic acid-induced osteopenia.
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The Apoptosis Regulator 14-3-3? and Its Potential as a Therapeutic Target in Pituitary Oncocytoma.
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The apoptotic effect of GSK-3 inhibitors: BIO and CHIR 98014 on H1975 lung cancer cells through ROS generation and mitochondrial dysfunction.
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The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer.
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The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.
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The ATM Gene in Breast Cancer: Its Relevance in Clinical Practice.
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The ATM rs189037 G>A polymorphism is associated with the risk and prognosis of gastric cancer in Chinese individuals: A case-control study.
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The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.
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The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules.
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The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.
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The Aurora A and B kinases are upregulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets.
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The Aurora A F31I polymorphism is not a risk factor for glioblastoma.
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The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation.
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The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo.
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The AURORA of a New Way to Value Myeloid Immunosuppression in Cancer.
Neoplasms
The Aurora-Kinase A Phe31-Ile polymorphism as possible predictor of response to treatment in head and neck squamous cell carcinoma.
Neoplasms
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.
Neoplasms
The biological complexity of RKIP signaling in human cancers.
Neoplasms
The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.
Neoplasms
The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.
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The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies.
Neoplasms
The Caspase-3/PKC?/Akt/VEGF-A Signaling Pathway Mediates Tumor Repopulation during Radiotherapy.
Neoplasms
The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry.
Neoplasms
The CD40/CD40L system regulates rat cerebral microvasculature after focal ischemia/reperfusion via the mTOR/S6K signaling pathway.
Neoplasms
The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.
Neoplasms
The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.
Neoplasms
The Chk1 inhibitor AZD7762 sensitises p53 mutant breast cancer cells to radiation in vitro and in vivo.
Neoplasms
The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy.
Neoplasms
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin.
Neoplasms
The CK2 inhibitor CX4945 reverses cisplatin resistance in the A549/DDP human lung adenocarcinoma cell line.
Neoplasms
The clinical features, treatment, and prognosis of primary mediastinal malignant melanoma: A case report.
Neoplasms
The clinical implication of 14-3-3 sigma expression in primary gastrointestinal malignancy.
Neoplasms
The Clinical Implications of RSK1-3 in Human Breast Cancer.
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The clinical relevance of the Hippo pathway in pancreatic ductal adenocarcinoma.
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The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma.
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The clinical value of Fibulin-1 for prognosis and its prospective mechanism in intrahepatic cholangiocarcinoma.
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The clinicopathological and prognostic impact of 14-3-3 protein isoforms expression in human cholangiocarcinoma by immunohistochemistry.
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The coiled-coil domain of oncogene RASSF 7 inhibits hippo signaling and promotes non-small cell lung cancer.
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The combined status of ATM and p53 link tumor development with therapeutic response.
Neoplasms
The conformation-specific Hsp90 inhibition interferes with the oncogenic RAF kinase adaptation and triggers premature cellular senescence, hence, acts as a tumor suppressor mechanism.
Neoplasms
The control of beta-catenin and TCF during embryonic development and cancer.
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The cross-talk of NOTCH and GSK-3 signaling in colon and other cancers.
Neoplasms
The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor.
Neoplasms
The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.
Neoplasms
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.
Neoplasms
The death-inducing activity of RIPK1 is regulated by the pH environment.
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The depletion of ATM inhibits colon cancer proliferation and migration via B56?2-mediated Chk1/p53/CD44 cascades.
Neoplasms
The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3? inhibitors for the treatment of ovarian cancer.
Neoplasms
The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.
Neoplasms
The DNA-PK inhibitor VX-984 enhances the radiosensitivity of glioblastoma cells grown in vitro and as orthotopic xenografts.
Neoplasms
The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro.
Neoplasms
The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells.
Neoplasms
The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein-protein interactions.
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The effect Akt2 deletion on tumor development in Pten(+/-) mice.
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The effect of functional MAPKAPK2 copy number variation CNV-30450 on elevating nasopharyngeal carcinoma risk is modulated by EBV infection.
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The Effect of LKB1 Activity on the Sensitivity to PI3K/mTOR Inhibition in Non-Small Cell Lung Cancer.
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The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid.
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The Effect of Silencing HIF-1? Gene in BxPC-3 Cell Line on Glycolysis-Related Gene Expression, Cell Growth, Invasion, and Apoptosis.
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The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice.
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The effects of polyamine antimetabolites on polyamine-responsive casein kinase activity.
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The emerging role of CaMKII in cancer.
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The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.
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The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.
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The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
Neoplasms
The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation.
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The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.
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The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma.
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The expression levels and prognostic value of high temperature required A2 (HtrA2) in NSCLC.
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The Expression of Anti-Müllerian Hormone Type II Receptor (AMHRII) in Non-Gynecological Solid Tumors Offers Potential for Broad Therapeutic Intervention in Cancer.
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The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
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The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.
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The expression of RKIP, RhoGDI, galectin, c-Myc and p53 in gastrointestinal system of Cr(VI)-exposed rats.
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The expression of seven 14-3-3 isoforms in human meningioma.
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The expressions of Hedgehog and PI3K-AKT pathway components correlate with invasion and metastasis in hepatocellular carcinoma.
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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.
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The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer.
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The functional significance of 14-3-3 proteins in cancer: focus on lung cancer.
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The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor.
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The genetics of pituitary adenomas.
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The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer.
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The glycogen synthase kinase (GSK) 3beta represses RNA polymerase I transcription.
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The Glycogen Synthase Kinase 3? and ? Isoforms Differentially Regulates Interleukin-12p40 Expression in Endothelial Cells Stimulated with Peptidoglycan from Staphylococcus aureus.
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The growth and aggressive behavior of human osteosarcoma is regulated by a CaMKII-controlled autocrine VEGF signaling mechanism.
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The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network.
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The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.
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The hippo kinase STK38 ensures functionality of XPO1.
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The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
Neoplasms
The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase.
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The Immuno-Enhancement Effects of Tubiechong (Eupolyphaga sinensis) Lyophilized Powder in Cyclophosphamide-Induced Immunosuppressed Mice.
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The immunohistochemical expression of DNA-PKCS and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity.
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The induction of endoreduplication and polyploidy by elevated expression of 14-3-3?.
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The influence of STK11 mutation on acquired resistance to immunotherapy in advanced non-small cell lung cancer with Lynch syndrome: a case report and literature review.
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The inhibitor of calcium/calmodulin-dependent protein kinase II KN93 attenuates bone cancer pain via inhibition of KIF17/NR2B trafficking in mice.
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The integrity of cholesterol-enriched microdomains is essential for the constitutive high activity of protein kinase B in tumour cells.
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The interplay between MYC and HIF in the Warburg effect.
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The intracellular domain of L1CAM binds to casein kinase 2? and is neuroprotective via inhibition of the tumor suppressors PTEN and p53.
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The intriguing role of fibroblasts and c-Jun in the chemopreventive and therapeutic effect of finasteride on xenograft models of prostate cancer.
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The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.
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The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK.
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The Kinase Mirk/dyrk1B: A Possible Therapeutic Target in Pancreatic Cancer.
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The lack of Raf-1 kinase feedback regulation enhances antiapoptosis in cancer cells.
Neoplasms
The Landscape of Glycogen Synthase Kinase-3 Beta Genomic Alterations in Cancer.
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The LRRK2 G2019S mutation is associated with Parkinson disease and concomitant non-skin cancers.
Neoplasms
The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation.
Neoplasms
The mammalian target of rapamycin inhibitor everolimus (RAD001) in early breast cancer: results of a pre-operative study.
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The Mammalian Target of Rapamycin-70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma.
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The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.
Neoplasms
The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development.
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The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells.
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The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model.
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The mechanism of activation of monomeric B-Raf V600E.
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The Mechanism of Trivalent Inorganic Arsenic on HIF-1?: a Systematic Review and Meta-analysis.
Neoplasms
The Mechanistic Role of the Calcium-Activated Chloride Channel ANO1 in Tumor Growth and Signaling.
Neoplasms
The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line.
Neoplasms
The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation.
Neoplasms
The MK2/HuR signaling pathway regulates TNF-?-induced ICAM-1 expression by promoting the stabilization of ICAM-1 mRNA.
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The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
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The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Neoplasms
The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.
Neoplasms
The molecular mechanism of GADD153 in apoptosis of keloid fibroblasts exposed to botulinum toxin type A.
Neoplasms
The molecular regulation of GADD153 in apoptosis of cultured vascular smooth muscle cells by cyclic mechanical stretch.
Neoplasms
The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells.
Neoplasms
The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer.
Neoplasms
The mTOR Signaling Pathway is an Emerging Therapeutic Target in Multiple Myeloma.
Neoplasms
The MyD88 inhibitor TJ-M2010-2 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3? and MyD88/NF-?B signalling pathways.
Neoplasms
The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein.
Neoplasms
The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta.
Neoplasms
The novel non-immunological role and underlying mechanisms of B7-H3 in tumorigenesis.
Neoplasms
The onco-embryonic antigen ROR1 is expressed by a variety of human cancers.
Neoplasms
The oncogenic and prognostic role of PDK1 in the progression and metastasis of ovarian cancer.
Neoplasms
The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint.
Neoplasms
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
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The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer.
Neoplasms
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Neoplasms
The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.
Neoplasms
The p70S6K Specific Inhibitor PF-4708671 Impedes Non-Small Cell Lung Cancer Growth.
Neoplasms
The PARP inhibitor olaparib induces significant killing of ATM deficient lymphoid tumour cells in vitro and in vivo.
Neoplasms
The PDCD4/miR-21 pathway in medullary thyroid carcinoma.
Neoplasms
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice.
Neoplasms
The Pharmacogenomics "Side-Effect" of TP53/EGFR in Non-Small Cell Lung Cancer Companied with Atorvastatin Therapy: A Functional Network Analysis.
Neoplasms
The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review).
Neoplasms
The phospho-barcode of RIPK1: complementarity or redundancy?
Neoplasms
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.
Neoplasms
The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression.
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The phospholipid- and calcium-dependent protein kinase as a target in tumor chemotherapy.
Neoplasms
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling.
Neoplasms
The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor.
Neoplasms
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance.
Neoplasms
The PI3K/AKT/mTOR signalling pathway is active in salivary gland cancer and implies different functions and prognoses depending on cell localisation.
Neoplasms
The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva).
Neoplasms
The Possible Interactions and Therapeutic Roles of Lithium Chloride and Midkine on Cancer Treatment.
Neoplasms
The Possible Involvement of Glycogen Synthase Kinase-3 (GSK-3) in Diabetes, Cancer and Central Nervous System Diseases.
Neoplasms
The Potential Prognostic Value of Connexin 43 Expression in Head and Neck Squamous Cell Carcinomas.
Neoplasms
The potential use of protein kinase D inhibitors for prevention/treatment of epidermal tumors.
Neoplasms
The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells.
Neoplasms
The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling.
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The pro-metastatic RSK2-CREB signaling pathway upregulates the actin-binding protein Fascin-1 to promote tumor metastasis.
Neoplasms
The Prognostic Role of Ribosomal Protein S6 Kinase 1 Pathway in Patients With Solid Tumors: A Meta-Analysis.
Neoplasms
The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors.
Neoplasms
The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins.
Neoplasms
The promoter region of the human BUBR1 gene and its expression analysis in lung cancer.
Neoplasms
The Protective and Immunomodulatory Effects of Fucoidan Against 7,12-Dimethyl benz[a]anthracene-Induced Experimental Mammary Carcinogenesis Through the PD1/PDL1 Signaling Pathway in Rats.
Neoplasms
The protective effects of lixisenatide against inflammatory response in human rheumatoid arthritis fibroblast-like synoviocytes.
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The protein kinase 2 inhibitor CX-4945 regulates osteoclast and osteoblast differentiation in vitro.
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The protein kinase B/Akt signalling pathway in human malignancy.
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The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.
Neoplasms
The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells.
Neoplasms
The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin.
Neoplasms
The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis.
Neoplasms
The proto-oncogene Pim-1 is a target of miR-33a.
Neoplasms
The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining.
Neoplasms
The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
Neoplasms
The putative tumour suppressor microRNA-145, repressed by c-jun, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
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The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines.
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The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors?
Neoplasms
The rapamycin-regulated gene expression signature determines prognosis for breast cancer.
Neoplasms
The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase.
Neoplasms
The regulation of CHK2 in human cancer.
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The regulatory subunit of protein kinase CK2 is a specific A-Raf activator.
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The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa.
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The Relative Biological Effect of Spread-Out Bragg Peak Protons in Sensitive and Resistant Tumor Cells.
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The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.
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The residues between the two transformation effector sites of Epstein-Barr virus latent membrane protein 1 are not critical for B-lymphocyte growth transformation.
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The retinoid derivant ECPIRM selectively exhibited anti-proliferation effects in cutaneous T-Cell lymphoma via ITK-mediated signaling pathway.
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The RhoA dependent anti-metastatic function of RKIP in breast cancer.
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The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.
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The Role and Mechanism of CRT0066101 as an Effective Drug for Treatment of Triple-Negative Breast Cancer.
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The role and regulatory mechanism of 14-3-3 sigma in human breast cancer.
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The role of 14-3-3 proteins in gynecological tumors.
Neoplasms
The role of A-kinase anchoring proteins in cancer development.
Neoplasms
The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression.
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The role of autophagy in targeted therapy for acute myeloid leukemia.
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The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
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The Role of Dexmedetomidine in Hepatic Ischemia-Reperfusion Injury Via a Nitric Oxide-Dependent Mechanism in Rats.
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The role of exosomes and MYC in therapy resistance of acute myeloid leukemia: Challenges and opportunities.
Neoplasms
The role of glycogen synthase kinase 3 (GSK3) in cancer with emphasis on ovarian cancer development and progression: A comprehensive review.
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The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Neoplasms
The role of glycogen synthase kinase-3? (GSK-3?) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker.
Neoplasms
The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment.
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The role of GSK3 in metabolic pathway perturbations in cancer.
Neoplasms
The Role of Heparin Cofactor ? in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice.
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The role of JNK2 in toxic liver injury.
Neoplasms
The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses.
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The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray.
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The role of oxidized ATM in the regulation of oxidative stress-induced energy metabolism reprogramming of CAFs.
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The Role of p38 and CK2 Protein Kinases in the Response of RAW 264.7 Macrophages to Lipopolysaccharide.
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The Role of p53 Signaling in Colorectal Cancer.
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The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt.
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The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.
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The role of Pim kinase in immunomodulation.
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The role of protein disorder in the 14-3-3 interaction network.
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The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis.
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The role of protein kinase D (PKD) in intracellular nutrient sensing and regulation of adaptive responses to the obese environment.
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The role of Raf-1 kinase in diabetic retinopathy.
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The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review).
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The role of the 14-3-3 protein family in health, disease, and drug development.
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The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development.
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The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease.
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The roles and therapeutic potential of cyclin-dependent kinases (CDKs) in sarcoma.
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The roles of microbial products in the development of colorectal cancer: a review.
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The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation.
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The selectivity of inhibitors of protein kinase CK2: an update.
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The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway.
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The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.
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The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells.
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The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression.
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The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells.
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The signaling interplay of GSK-3? in myocardial disorders.
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The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice.
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The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A.
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The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme.
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The Ste20 kinase MST4 plays a role in prostate cancer progression.
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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.
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The STK11/LKB1 Peutz-Jegher gene is not involved in the pathogenesis of sporadic sex cord-stromal tumors, although loss of heterozygosity at 19p13.3 indicates other gene alteration in these tumors.
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The STK33-Linked SNP rs4929949 Is Associated with Obesity and BMI in Two Independent Cohorts of Swedish and Greek Children.
Neoplasms
The STK38-XPO1 axis, a new actor in physiology and cancer.
Neoplasms
The structural analysis of MARK4 and the exploration of specific inhibitors for the MARK family: a computational approach to obstruct the role of MARK4 in prostate cancer progression.
Neoplasms
The structure of C290A:C393A Aurora A provides structural insights into kinase regulation.
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The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling.
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The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells.
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The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors.
Neoplasms
The synthetic peptide CIGB-300 modulates CK2-dependent signaling pathways affecting the survival and chemoresistance of non-small cell lung cancer cell lines.
Neoplasms
The Tanapoxvirus 142R Protein is a Serine-Threonine Kinase that Phosphorylates the Tumor Suppressor p53.
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The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.
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The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer.
Neoplasms
The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling.
Neoplasms
The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation.
Neoplasms
The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR.
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The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells.
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The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development.
Neoplasms
The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis.
Neoplasms
The tumor suppressor LKB1 antagonizes WNT signaling pathway through modulating GSK3? activity in cell growth of esophageal carcinoma.
Neoplasms
The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1.
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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Neoplasms
The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function.
Neoplasms
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation.
Neoplasms
The tumour suppressor protein, p53, is involved in the activation of the apoptotic cascade by Delta9-tetrahydrocannabinol in cultured cortical neurons.
Neoplasms
The tyrosine kinase Syk regulates TPL2 activation signals.
Neoplasms
The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-Lbc.
Neoplasms
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
Neoplasms
The VHL tumor suppressor: riding tandem with GSK3beta in primary cilium maintenance.
Neoplasms
The vitamin nicotinamide: translating nutrition into clinical care.
Neoplasms
The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase.
Neoplasms
The Wnt antagonist and secreted frizzled-related protein 5: implications on lipid metabolism, inflammation, and type 2 diabetes mellitus.
Neoplasms
Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.
Neoplasms
Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice.
Neoplasms
Therapeutic effects of 1,25-dihydroxyvitamin D3 on diabetes-induced liver complications in a rat model.
Neoplasms
Therapeutic efficacy of curcumin/TRAIL combination regimen for hormone-refractory prostate cancer.
Neoplasms
Therapeutic opportunities in colon cancer: Focus on phosphodiesterase inhibitors.
Neoplasms
Therapeutic relevance of the protein phosphatase 2A in cancer.
Neoplasms
Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors.
Neoplasms
Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects.
Neoplasms
Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer.
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Therapeutic targeting of protein kinase CK2 gene expression in feline oral squamous cell carcinoma - a naturally occurring large animal model of head and neck cancer.
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Therapeutic targets and molecular mechanism of calycosin for the treatment of cerebral ischemia/reperfusion injury.
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Thiamin deficiency induces impaired fish gill immune responses, tight junction protein expression and antioxidant capacity: Roles of the NF-?B, TOR, p38 MAPK and Nrf2 signaling molecules.
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Thienopyrimidine-Chalcone Hybrid Molecules Inhibit Fas-Activated Serine/Threonine Kinase: An Approach To Ameliorate Antiproliferation in Human Breast Cancer Cells.
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Thioredoxin-1 Is a Target to Attenuate Alzheimer-Like Pathology in Diabetic Encephalopathy by Alleviating Endoplasmic Reticulum Stress and Oxidative Stress.
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Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.
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Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship.
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Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells.
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Time to incorporate germline multigene panel testing into breast and ovarian cancer patient care.
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Timosaponin AIII, a steroidal saponin, exhibits anti-tumor effect on taxol-resistant cells in vitro and in vivo.
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TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy.
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Tissue Factor/ FVIIa prevents the extrinsic pathway of apoptosis by regulation of the tumor suppressor Death-Associated Protein Kinase 1 (DAPK1).
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Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.
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Tissue microarray analysis of ezrin, KBA.62, CD166, nestin, and p-Akt in melanoma versus banal and atypical nevi, and nonmelanocytic lesions.
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Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function.
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TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling.
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TLRs, NF-?B, JNK, and Liver Regeneration.
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TM4SF4 and LRRK2 are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis.
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TMEM17 promotes malignant progression of breast cancer via AKT/GSK3? signaling.
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TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L).
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TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta.
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TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
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TNF? disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice.
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TNF? plays a significant role in the Aldara-induced skin inflammation in mice.
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TOPK is regulated by PP2A and BCR/ABL in leukemia and enhances cell proliferation.
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TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy.
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Topological polar surface area: a useful descriptor in 2D-QSAR.
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Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
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Toward an early diagnosis of lung cancer: an autoantibody signature for squamous cell lung carcinoma.
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TP53, STK11, and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti-PD-1 in Lung Adenocarcinoma.
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Tpl-2/cot and cox-2 in breast cancer.
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Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.
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Tpl2 is a key mediator of arsenite-induced signal transduction.
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TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection.
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Tpl2 kinase signal transduction in inflammation and cancer.
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Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination.
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Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing.
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TPX2 Level Correlates with Hepatocellular Carcinoma Cell Proliferation, Apoptosis, and EMT.
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TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor.
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TRAF-mediated modulation of NF-kB AND JNK activation by TNFR2.
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TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.
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TRAF2 phosphorylation promotes NF-?B-dependent gene expression and inhibits oxidative stress-induced cell death.
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TRAF2 Suppresses Basal IKK Activity in Resting Cells and TNFalpha Can Activate IKK in TRAF2 and TRAF5 Double Knockout Cells.
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TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation.
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TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3beta cascade is required for TNF-induced cell survival.
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Trafficking to the Cell Surface of Amino Acid Transporter SLC6A14 Upregulated in Cancer Is Controlled by Phosphorylation of SEC24C Protein by AKT Kinase.
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TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.
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Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys.
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Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-?1 /Smad2/3 pathway.
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Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice.
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Transcriptional regulation of G2/M regulatory proteins and perturbation of G2/M Cell cycle transition by a traditional Chinese medicine recipe.
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Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth.
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Transcriptional Regulation of YWHAZ, the Gene Encoding 14-3-3?.
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Transcriptional Repression of Raf Kinase Inhibitory Protein Gene by Metadherin during Cancer Progression.
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Transcriptome and Function of Novel Immunosuppressive Autoreactive Invariant Natural Killer T Cells That Are Absent in Progressive Multiple Sclerosis.
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Transcriptome sequencing identifies genes associated with invasion of ovarian cancer.
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Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells.
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Transcriptomic analysis reveals the oncogenic role of S6K1 in hepatocellular carcinoma.
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Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.
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Transformation by v-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors.
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Transformation of hemopoietic cells by raf and myc oncogenes: a new perspective on lineage commitment.
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Transgenic expression of E2F3a causes DNA damage leading to ATM-dependent apoptosis.
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Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissues.
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Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both MIRK/DYRK1B and p130/RB2.
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Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes.
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Transient Receptor Potential Ankyrin 1 (TRPA1)-An Inflammation-Induced Factor in Human HaCaT Keratinocytes.
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Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase.
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Translational Exposure-Efficacy Modeling to Optimize the Dose and Schedule of Taxanes Combined with the Investigational Aurora A Kinase Inhibitor MLN8237 (Alisertib).
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Treatment of acromegaly in the era of personalized and predictive medicine.
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Treatment of chronic kidney disease using a traditional Chinese medicine, Flos Abelmoschus manihot (Linnaeus) Medicus (Malvaceae).
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Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton.
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Trehalose and N-Acetyl Cysteine Alleviate Inflammatory Cytokine Production and Oxidative Stress in LPS-Stimulated Human Peripheral Blood Mononuclear Cells.
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Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy.
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Trichinella pseudospiralis infection is characterized by more continuous and diffuse myopathy than T. spiralis infection.
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Triclosan inhibits tumor necrosis factor-alpha-stimulated urokinase production in human gingival fibroblasts.
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TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4.
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TRIP4 promotes tumor growth and metastasis and regulates radiosensitivity of cervical cancer by activating MAPK, PI3K/AKT, and hTERT signaling.
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Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation.
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Triptolide sensitizes cisplatin-resistant human epithelial ovarian cancer by inhibiting the phosphorylation of AKT.
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Trovafloxacin Potentiation of Lipopolysaccharide-Induced Tumor Necrosis Factor Release from RAW 264.7 Cells Requires Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase.
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Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.
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Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-? and p53 signaling.
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Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases.
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Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM).
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Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.
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Tuberous sclerosis genes regulate cellular 14-3-3 protein levels.
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Tug of War between Survival and Death: Exploring ATM Function in Cancer.
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Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.
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Tumor cell radiosensitivity is a major determinant of tumor response to radiation.
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Tumor Cell-Accelerated Senescence Is Associated With DNA-PKcs Status and Telomere Dysfunction Induced by Radiation.
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Tumor DNA-dependent protein kinase catalytic subunit expression is associated with hepatitis B surface antigen status and tumor progression in patients with hepatocellular carcinoma.
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Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.
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Tumor hypoxia directed multimodal nanotherapy for overcoming drug resistance in renal cell carcinoma and reprogramming macrophages.
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Tumor hypoxia represses ?? T cell-mediated antitumor immunity against brain tumors.
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Tumor microenvironment disparity in multiple primary lung cancers: Impact of non-intrinsic factors, histological subtypes, and genetic aberrations.
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Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.
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Tumor necrosis factor alpha promotes the proliferation of human nucleus pulposus cells via nuclear factor-?B, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.
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Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2.
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Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II.
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Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase.
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Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.
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Tumor necrosis factor-? enhances RANKL expression in gingival epithelial cells via protein kinase A signaling.
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Tumor necrosis factor-? mediates JNK activation response to intestinal ischemia-reperfusion injury.
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Tumor Necrosis Factor-?-Induced Apoptosis in the Intestinal Epithelium due to Chronic Nuclear Factor Kappa B Signaling Is Mediated by Receptor Interacting Serine/Threonine Kinase 1.
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Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis.
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Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1.
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Tumor necrosis factor-alpha inhibits differentiation of myogenic cells in human urethral rhabdosphincter.
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Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.
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Tumor necrosis factor-alpha-induced sickness behavior is impaired by central administration of an inhibitor of c-jun N-terminal kinase.
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Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway.
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Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways.
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Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of MMP-9 in myopathy.
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Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.
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Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
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Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice.
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Tumor progression locus 2 in hepatocytes potentiates both liver and systemic metabolic disorders.
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Tumor promoter TPA activates Wnt/?-catenin signaling in a casein kinase 1-dependent manner.
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Tumor reversion: protein kinase a isozyme switching.
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Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.
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Tumor suppression by LKB1: SIK-ness prevents metastasis.
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Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain.
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Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-?1 in orchestrating profibrotic responses.
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Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle, c-Jun N-terminal kinase and the cyclin D1 promoter.
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Tumor suppressor CHK2: regulator of DNA damage response and mediator of chromosomal stability.
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Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation.
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Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients.
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Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1.
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Tumor suppressor LATS1 is a negative regulator of oncogene YAP.
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Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC).
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Tumor Suppressor Lzap Suppresses Wnt/?-Catenin Signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of Glycogen Synthase Kinase 3.
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Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46.
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Tumor suppressor RKIP inhibits prostate cancer cell metastasis and sensitizes prostate cancer cells to docetaxel treatment.
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Tumor suppressor role of notch1 and raf-1 signaling in medullary thyroid cancer cells.
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Tumor Suppressor Serine/Threonine Kinase LKB1 Expression, Not Kinase Activity, Increased in the Vascular Smooth Muscle Cells and Neointima in the Rat Carotid Artery Injury Model.
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Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function.
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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
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Tumor-specific Activation of the c-JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53-dependent Manner.
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Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin/transforming growth factor-beta receptors in human pituitary adenomas.
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Tumors initiated by constitutive Cdk2 activation exhibit transforming growth factor beta resistance and acquire paracrine mitogenic stimulation during progression.
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Tumour maintenance is mediated by eNOS.
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Tumour necrosis factor-alpha activation of protein kinase B in WEHI-164 cells is accompanied by increased phosphorylation of Ser473, but not Thr308.
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Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not.
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Tumour suppressor PTEN regulates cell cycle and protein kinase B/Akt pathway in breast cancer cells.
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Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.
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TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
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Twist1 and AP-1 cooperatively upregulate integrin ?5 expression to induce invasion and the epithelial-mesenchymal transition.
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Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk.
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Two newly identified sites in the N-terminal regulatory domain of Aurora-A are essential for auto-inhibition.
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Two novel mutations and a new STK11/LKB1 gene isoform in Peutz-Jeghers patients.
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Two TPX2-dependent switches control the activity of Aurora A.
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Two-stage case-control study of common ATM gene variants in relation to breast cancer risk.
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TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
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Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).
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Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells.
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Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways.
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Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
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Ultrasound Stimulation Suppresses LPS-Induced Proinflammatory Responses by Regulating NF-?B and CREB Activation in Microglial Cells.
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Ultrasound-Targeted Microbubble Destruction-Mediated Downregulation of EZH2 Inhibits Stemness and Epithelial-Mesenchymal Transition of Liver Cancer Stem Cells.
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Umbralisib: First Approval.
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Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction.
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Uncoupling of protein kinase D from suppression of EGF-dependent c-Jun phosphorylation in cancer cells.
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Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease.
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Under-expression of CK2? subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival.
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Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis.
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Understanding the relative affinity and specificity of the pleckstrin homology domain of protein kinase B for inositol phosphates.
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Understanding the role of glycogen synthase kinase-3 in L-DOPA-induced dyskinesia in Parkinson's disease.
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Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2? and Its Paralog CK2?'.
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Unexpected CK2?-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2.
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Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies.
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Unexpected role for the human Cx37 C1019T polymorphism in tumour cell proliferation.
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Unholy matrimony: Aurora A and N-Myc as malignant partners in neuroblastoma.
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Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.
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Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway.
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Unlocking the code of 14-3-3.
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Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical stage for the treatment of cancer.
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Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach.
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Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer.
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Up-regulation of 14-3-3? expression in intrahepatic cholangiocarcinoma and its clinical implications.
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Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.
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Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.
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Updates on HIPK2: a resourceful oncosuppressor for clearing cancer.
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Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
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Upregulation of AKAP12 with HDAC3 depletion suppresses the progression and migration of colorectal cancer.
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Upregulation of LIMK1 Is Correlated With Poor Prognosis and Immune Infiltrates in Lung Adenocarcinoma.
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Upregulation of long noncoding RNA TUG1 contributes to the development of laryngocarcinoma by targeting miR-145-5p/ROCK1 axis.
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Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma.
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Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1.
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Upregulation of Na-coupled glucose transporter SGLT1 by Tau tubulin kinase 2.
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Upregulation of P21-Activated Kinase 1 (PAK1)/CREB Axis in Squamous Non-Small Cell Lung Carcinoma.
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Upregulation of pAKT(Ser473) expression is involved in progression of HPV-positive oropharyngeal squamous cell carcinoma.
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Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.
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Upregulation of Stress-Induced Protein Kinase CK1 Delta is associated with a Poor Prognosis for patients with Hepatocellular Carcinoma.
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Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential.
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Upregulation of Thr/Tyr kinase Increases the Cancer Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer.
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Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma.
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Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors.
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Urotensin II inhibitor eases neuropathic pain by suppressing the JNK/NF-?B pathway.
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Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway.
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Use of lithium and cancer risk in patients with bipolar disorder: population-based cohort study.
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Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure.
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Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy (review).
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Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors.
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Using insights into Pim1 structure to design new anticancer drugs.
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Using Molecular Docking Analysis to Discovery Dregea sinensis Hemsl. Potential Mechanism of Anticancer, Antidepression, and Immunoregulation.
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Using Pharmacokinetic Profiles and Digital Quantification of Stained Tissue Microarrays as a Medium-Throughput, Quantitative Method for Measuring the Kinetics of Early Signaling Changes Following Integrin-Linked Kinase Inhibition in an In Vivo Model of Cancer.
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USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2.
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Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Morphologic and Molecular Study of 26 Cases Confirms Recurrent NCOA1-3 Rearrangement.
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Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1-APC Interaction in Modulating Wnt/?-Catenin Pathway of Lung Cancer Cells.
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Utilizing integrating network pharmacological approaches to investigate the potential mechanism of Ma Xing Shi Gan Decoction in treating COVID-19.
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v-myc and v-raf act synergistically to induce B-cell tumors in pristane-primed adult BALBC mice.
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Validation of a liquid chromatography assay for the quantification of the Raf kinase inhibitor BAY 43-9006 in small volumes of mouse serum.
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Validation of protein kinase CK2 as oncological target.
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Vanillin protects human keratinocyte stem cells against ultraviolet B irradiation.
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Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses.
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Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice.
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Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1.
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Vav1 downmodulates Akt in different breast cancer subtypes: a new promising chance to improve breast cancer outcome.
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Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancer.
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Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
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VIP induces NF-?B1-nuclear localisation through different signalling pathways in human tumour and non-tumour prostate cells.
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Viral oncolysis that targets Raf-1 signaling control of nuclear transport.
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Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype.
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Virtual Screening of 1,4-Naphthoquinone Derivatives for Inhibition of a Key Cancer Signaling Protein, AKT1 Kinase.
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Vitamin E Facilitates the Inactivation of the Kinase Akt by the Phosphatase PHLPP1.
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Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
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Vulvar Squamous Cell Carcinoma: Comprehensive Genomic Profiling of HPV+ Versus HPV- Forms Reveals Distinct Sets of Potentially Actionable Molecular Targets.
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VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.
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VX680 Binding in Aurora A: ?-? Interactions Involving the Conserved Aromatic Amino Acid of the Flexible Glycine-Rich Loop.
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VX680/MK-0457, a potent and selective Aurora kinase inhibitor, targets both tumor and endothelial cells in clear cell renal cell carcinoma.
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Walking forward: a program designed to lower cancer mortality rates among American Indians in western South Dakota.
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WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.
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WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.
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Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy.
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WEE1 Kinase Inhibitor AZD1775 Has Preclinical Efficacy in LKB1-Deficient Non-Small Cell Lung Cancer.
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Weighted genes associated with the progression of retinoblastoma: Evidence from bioinformatic analysis.
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WF-536 inhibits metastatic invasion by enhancing the host cell barrier and inhibiting tumour cell motility.
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Whole Exome Profiling of NSCLC Among African Americans.
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Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.
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Why is PAK4 overexpressed in cancer?
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Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways.
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Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells.
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Withdrawal: A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
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Withdrawal: Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway.
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WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis.
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Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin.
Neoplasms
Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells.
Neoplasms
Wnt-independent beta-catenin transactivation in tumor development.
Neoplasms
Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta.
Neoplasms
Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells.
Neoplasms
Wogonin inhibits cell cycle progression by activating the glycogen synthase kinase-3 beta in hepatocellular carcinoma.
Neoplasms
Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002.
Neoplasms
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
Neoplasms
Xiaoyao Kangai Jieyu Fang, a Chinese Herbal Formulation, Ameliorates Cancer-Related Depression Concurrent with Breast Cancer in Mice via Promoting Hippocampal Synaptic Plasticity.
Neoplasms
YAP promotes malignant progression of Lkb1-deficient lung adenocarcinoma through downstream regulation of survivin.
Neoplasms
YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease.
Neoplasms
Yap1 Acts Downstream of ?-Catenin to Control Epidermal Proliferation.
Neoplasms
Yeast 14-3-3 proteins.
Neoplasms
Yield and Clinical Utility of Next-Generation Sequencing in Selected Patients With Lung Adenocarcinoma.
Neoplasms
Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells.
Neoplasms
Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling.
Neoplasms
Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function.
Neoplasms
ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells.
Neoplasms
Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt.
Neoplasms
Zyxin Is a Critical Regulator of the Apoptotic HIPK2-p53 Signaling Axis.
Neoplasms
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor.
Neoplasms
[(11)C-carbonyl]CEP-32496: radiosynthesis, biodistribution and PET study of brain uptake in P-gp/BCRP knockout mice.
Neoplasms
[Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]
Neoplasms
[Analyzed the molecular interaction network of tumor suppressor gene 14-3-3 sigma in lung cancer cell based on stable isotope labeling by amino acids in cell culture technology].
Neoplasms
[Ataxia telangiectasia]
Neoplasms
[Changes in protein kinase activity of the skin in cancer]
Neoplasms
[Changes of serum miR-375 and blood target genes in patients with allergic rhinitis before and after treatment and its significance].
Neoplasms
[Citron Rho-interacting serine/threonine kinase knockdown suppresses prostate cancer cell proliferation and metastasis by blocking Hippo-YAP pathway].
Neoplasms
[CK2? Regulates the Metastases and Migration of Lung Adenocarcinoma ?A549 Cell Line through PI3K/Akt/GSK-3? Signal Pathway].
Neoplasms
[Clinicopathological significance of expressions of DNA dependent protein kinase catalytic subunit and P16 in colorectal carcinoma]
Neoplasms
[Cloning, sequencing, expression, and primary identification of recombinant mouse protein kinase CK2 alpha subunit]
Neoplasms
[Correlation of casein kinase 2? overexpression to the metastatic ability of colorectal cancer cells in vitro].
Neoplasms
[Correlation of HIPK2 expression with HPV infection and apoptosis in cervical cancer]
Neoplasms
[Correlation of p38 mitogen-activated protein kinase signal transduction pathway to uPA expression in breast cancer]
Neoplasms
[Determination of cyclic AMP and protein kinases in the diagnosis of colonic tumors]
Neoplasms
[Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium]
Neoplasms
[Effect of moxa-burning heat stimulating Liangmen (ST 21) and Zusanli (ST 36) on proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer].
Neoplasms
[Effect of protein kinase CK2 gene silencing on radiosensitization in human nasopharyngeal carcinoma cells]
Neoplasms
[Effects of Na(+) /H(+) exchanger 1 inhibitor on intestinal injury of rats with burn sepsis and the mechanism].
Neoplasms
[Effects of Sanchinoside R1 on Growth Invasion and Migration of HL-60 Cells and Survival of AML Model Mice].
Neoplasms
[Erythropoietin accelerates the proliferation of glioma cells via activating Akt pathway].
Neoplasms
[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer]
Neoplasms
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Neoplasms
[Expression and significance of p-AKT, p-GSK3? and ?-catenin in epithelial carcinoma of ovary].
Neoplasms
[Expression of DNA-PK in hepato- and cholangio-neoplasms and its significance.]
Neoplasms
[Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]
Neoplasms
[Expression of p-AKT and p-mTOR in pediatric Burkitt lymphoma and their correlation with prognosis].
Neoplasms
[Expression of phosphorylated protein kinase B and PTEN protein in ovarian epithelial cancer]
Neoplasms
[Expression of PKB protein in human squamous-cell carcinoma and adenocarcinoma of lung]
Neoplasms
[Expressions of Raf-1 kinase, phosphorylated mitogen extracellular kinase 1, and phosphorylated extracellular signal-regulated protein kinase 1/2 in hepatocellular carcinoma and their relationship with prognosis]
Neoplasms
[Expressions of SMG-1, ATM and P53 in laryngeal squamous cell carcinoma and their clinical significance].
Neoplasms
[Feiyanning Decoction down-regulates the expressions of phosphorylated Akt and hypoxia inducible factor-1alpha proteins in transplanted lung adenocarcinoma in nude mice]
Neoplasms
[Hypermethylation of DAP-kinase gene CpG Island in malignant lymphoma with B-cell phenotype]
Neoplasms
[Immune regulatory effect of citalopram on microglial cells].
Neoplasms
[Implications of genetic risk factors in breast cancer: culprit genes and associated malignancies]
Neoplasms
[Inhibitory effect and its kinetic analysis of baicalein on recombinant human protein kinase CK2 holoenzyme]
Neoplasms
[Inhibitory effect of AG1109 on recombinant human protein kinase CK2 holoenzyme]
Neoplasms
[Inhibitory effect of antisense and dominant-negative AKT2 constructs on proliferation of glioma cell line TJ905.]
Neoplasms
[Mammalian target of rapamycin inhibitors for the targeted therapy of non-small cell lung cancer]
Neoplasms
[Mechanism of Chlorogenic Acid in Apoptotic Regulation through Notch1 ?Pathway in Non-small Cell Lung Carcinoma in Animal Level].
Neoplasms
[Ponatinib inhibits growth of patient-derived xenograft of cholangiocarcinoma expressing FGFR2-CCDC6 fusion protein in nude mice].
Neoplasms
[Potential sensitivity to metformin of the diabetics suffering and not suffering with cancer: a pharmacogenetic study].
Neoplasms
[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]
Neoplasms
[PRKAR1A gene mutations in two patients with myxoma syndrome (Carney complex)]
Neoplasms
[Prognostic value of combined expression of Aurora A, p53 and p21 WAF1 in patients after curative resection of non-small cell lung cancer].
Neoplasms
[Progress in the study of small molecule inhibitors of HSP90].
Neoplasms
[Progress of researches on mechanisms of acupuncture underlying improvement of depression in the past five years].
Neoplasms
[Protein kinase CK2 and cancer: further clues are accumulating]
Neoplasms
[Protein kinase D1 regulates the growth and metabolism of oral squamous carcinoma cells in tumor microenvironment].
Neoplasms
[Rare hereditary syndromes associated with polyposis and the development of malignant tumors].
Neoplasms
[RNA interference targeting DNA-PKcs inhibits glioma cells malignancies and enhances temozolomide sensitivity].
Neoplasms
[Role of JNK signal transduction pathway in nonalcoholic fatty liver disease]
Neoplasms
[Role of miR-106b-5p in the regulation of gene profiles in endothelial cells].
Neoplasms
[Serum pancreatic enzyme elevation under treatment with sorafenib].
Neoplasms
[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms]
Neoplasms
[Study of the expression of Aurora kinases in renal cell carcinoma].
Neoplasms
[Study on effect and mechanism of Honokiol enhancing tumor necrosis factor-related apoptosis inducing ligand against hepatocellular carcinoma HepG2 cells via activating JNK signaling pathway].
Neoplasms
[Study on the relationship between Aurora A expression in cancer cell and treatment efficacy of taxol for prostate cancer]
Neoplasms
[Synergistic effect of thermotherapy in combination with chemotherapy on lung tumor A549 cells growth through activation of c-Jun N-terminal kinase and inhibition of heat shock protein70 expression]
Neoplasms
[The basics of 14-3-3 protein family and research progress on therapeutic applications of 14-3-3 protein]
Neoplasms
[The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.]
Neoplasms
[The expression of PIK3CA in nasopharyngeal carcinoma].
Neoplasms
[The function of Aurora A and its role in the development of liver cancer].
Neoplasms
[The research on the mechanism of Pim-2 suppressing the apoptosis of tumor cell]
Neoplasms
[The role for oxidative stress in neurodegenerative diseases]
Neoplasms
[The role of arecoline on hepatic insulin resistance in type 2 diabetes rats].
Neoplasms
[The underlying mechanisms of overcoming EGFR-TKIs resistance by casein kinase 2 inhibitor].
Neoplasms
[Value of determining casein kinase activity in the diagnosis of cancer of the large intestine]
Neoplasms
ß-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.
Neoplasms, Germ Cell and Embryonal
Differential Akt signalling in non-seminomatous testicular germ cell tumors.
Neoplasms, Germ Cell and Embryonal
Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A.
Neoplasms, Glandular and Epithelial
HIPK2 expression in progression of cutaneous epithelial neoplasm.
Neoplasms, Squamous Cell
Expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in esophageal cancer and their association with the clinical and pathological parameters.
Neoplasms, Squamous Cell
Multiple squamous cell carcinomas of the skin after therapy with sorafenib combined with tipifarnib.
Neoplastic Cells, Circulating
Comparison of the PI3KCA pathway in circulating tumor cells and corresponding tumor tissue of patients with metastatic breast cancer.
Neoplastic Processes
Mammalian target of rapamycin (mTOR) inhibitors as anti-cancer agents.
Neoplastic Processes
Serum- and glucocorticoid-inducible kinase 3 is a potential oncogene in nasopharyngeal carcinoma.
Nephritis
Immune-Mediated Nephropathy and Systemic Autoimmunity in Mice Does Not Require Receptor Interacting Protein Kinase 3 (RIPK3).
Nephritis
LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production.
Nephritis
Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.
Nephrogenic Fibrosing Dermopathy
Differential Expression of Hedgehog and Snail in Cutaneous Fibrosing Disorders: Implications for Targeted Inhibition.
Nephrolithiasis
Inflammatory Cytokines in the Papillary Tips and Urine of Nephrolithiasis Patients.
Nervous System Diseases
14-3-3 proteins at the crossroads of neurodevelopment and schizophrenia.
Nervous System Diseases
14-3-3 proteins in neurological disorders.
Nervous System Diseases
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Nervous System Diseases
A ?1/2 adrenergic receptor-sensitive intracellular signaling pathway modulates CCL2 production in cultured spinal astrocytes.
Nervous System Diseases
Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009.
Nervous System Diseases
An enzyme-linked immunosorbent assay to quantify 14-3-3 proteins in the cerebrospinal fluid of suspected Creutzfeldt-Jakob disease patients.
Nervous System Diseases
Bi-directional genetic modulation of GSK-3? exacerbates hippocampal neuropathology in experimental status epilepticus.
Nervous System Diseases
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.
Nervous System Diseases
Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis.
Nervous System Diseases
Commonly Used Anesthesia/Euthanasia Methods for Brain Collection Differentially Impact MAPK Activity in Male and Female C57BL/6 Mice.
Nervous System Diseases
Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders.
Nervous System Diseases
Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders
Nervous System Diseases
Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders.
Nervous System Diseases
Detection of 14-3-3 protein in the cerebrospinal fluid in mitochondrial encephalopathy with lactic acidosis and stroke-like episodes.
Nervous System Diseases
Dynamic range of GSK3? not GSK3? is essential for bidirectional synaptic plasticity at hippocampal CA3-CA1 synapses.
Nervous System Diseases
Expression profile of PTPIP51 in mouse brain.
Nervous System Diseases
Extracellular vesicles in the diagnosis and treatment of central nervous system diseases.
Nervous System Diseases
From the low-density lipoprotein receptor-related protein 1 to neuropathic pain: a potentially novel target.
Nervous System Diseases
Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.
Nervous System Diseases
Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target?
Nervous System Diseases
Glycogen Synthase Kinase-3beta is a Functional Modulator of Serotonin 1B Receptors.
Nervous System Diseases
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS.
Nervous System Diseases
GSK-3 mediates the release of IL-1?, TNF-? and IL-10 from cortical glia.
Nervous System Diseases
GSK3? isoform-selective regulation of depression, memory and hippocampal cell proliferation.
Nervous System Diseases
Human 14-3-3 protein: radioimmunoassay, tissue distribution, and cerebrospinal fluid levels in patients with neurological disorders.
Nervous System Diseases
Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates.
Nervous System Diseases
Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3?
Nervous System Diseases
LTP inhibits LTD in the hippocampus via regulation of GSK3beta.
Nervous System Diseases
MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease.
Nervous System Diseases
Missense mutations in CASK, coding for the calcium-/calmodulin-dependent serine protein kinase, interfere with neurexin binding and neurexin-induced oligomerization.
Nervous System Diseases
Novel PRNP mutation in a patient with a slow progressive dementia syndrome.
Nervous System Diseases
Peptide Substrates for Rho-Associated Kinase 2 (Rho-Kinase 2/ROCK2).
Nervous System Diseases
Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders.
Nervous System Diseases
Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.
Nervous System Diseases
ROCK1 and ROCK2 inhibition alters dendritic spine morphology in hippocampal neurons.
Nervous System Diseases
Serum ROCK1 mRNA is of great diagnostic value for glioma patients.
Nervous System Diseases
Synthesis and Initial in Vivo Studies with [(11)C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3.
Nervous System Diseases
Synthesis of Coumarin Derivatives as Versatile Scaffolds for GSK-3? Enzyme Inhibition.
Nervous System Diseases
The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis.
Nervous System Diseases
The role of posttranslational modifications of ?-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors.
Nervous System Diseases
Theoretical study of GSK-3?: neural networks QSAR studies for the design of new inhibitors using 2D descriptors.
Nervous System Diseases
Unlocking the code of 14-3-3.
Nervous System Diseases
[The basics of 14-3-3 protein family and research progress on therapeutic applications of 14-3-3 protein]
Nervous System Neoplasms
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Neural Tube Defects
Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.
Neural Tube Defects
Protein kinase A deficiency causes axially localized neural tube defects in mice.
Neuralgia
A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.
Neuralgia
A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats.
Neuralgia
Activation of CaMKII and GluR1 by the PSD-95-GluN2B Coupling-Dependent Phosphorylation of GluN2B in the Spinal Cord in a Rat Model of Type-2 Diabetic Neuropathic Pain.
Neuralgia
Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury.
Neuralgia
Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats.
Neuralgia
Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice.
Neuralgia
Anti-hyperalgesic effect of CaMKII inhibitor is associated with downregulation of phosphorylated CREB in rat spinal cord.
Neuralgia
Benefits of exercise intervention in reducing neuropathic pain.
Neuralgia
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy.
Neuralgia
Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury.
Neuralgia
CaMKII and CaV3.2 T-type calcium channel mediate Connexin-43-dependent inflammation by activating astrocytes in vincristine-induced neuropathic pain.
Neuralgia
Cellular and molecular mechanisms of calcium/calmodulin-dependent protein kinase II in chronic pain.
Neuralgia
Changes of calcium/calmodulin-dependent protein kinase II expression in dorsal root ganglia during maturation in long-term diabetes.
Neuralgia
Curcumin could prevent the development of chronic neuropathic pain in rats with peripheral nerve injury.
Neuralgia
Decreased Activity in Neuropathic Pain Form and Gene Expression of Cyclin-Dependent Kinase5 and Glycogen Synthase Kinase-3 Beta in Soleus Muscle of Wistar Male Rats.
Neuralgia
Docosahexaenoic acid confers analgesic effects after median nerve injury via inhibition of c-Jun N-terminal kinase activation in microglia.
Neuralgia
Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion.
Neuralgia
Galanin receptor 1 plays an antinociceptive effect via inhibiting PKA activation in the nucleus accumbens of rats with neuropathic pain.
Neuralgia
Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain.
Neuralgia
Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action.
Neuralgia
HCN2 contributes to oxaliplatin-induced neuropathic pain by inducing spinal long-term potentiation via activation of NMDA receptor-mediated CaMKII signaling.
Neuralgia
Histone deacetylase inhibition inhibits brachial plexus avulsion-induced neuropathic pain.
Neuralgia
Identification of Natural Compounds against Neurodegenerative Diseases Using In Silico Techniques.
Neuralgia
Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472.
Neuralgia
Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain.
Neuralgia
Inhibition of glycogen synthase kinase 3beta activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain.
Neuralgia
Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain.
Neuralgia
Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain.
Neuralgia
Involvement of protein kinase B/Akt in analgesic effect of dexmedetomidine on neuropathic pain.
Neuralgia
Mammalian target of rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation.
Neuralgia
MC4R Is Involved in Neuropathic Pain by Regulating JNK Signaling Pathway After Chronic Constriction Injury.
Neuralgia
Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation.
Neuralgia
Neurobiological mechanisms of pain in sickle cell disease.
Neuralgia
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain.
Neuralgia
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology.
Neuralgia
Perturbing NR2B-PSD-95 interaction relieves neuropathic pain by inactivating CaMKII-CREB signaling.
Neuralgia
Phosphorylation of c-Jun N-terminal kinase (JNK) in sensory neurones of diabetic rats, with possible effects on nerve conduction and neuropathic pain: prevention with an aldose reductase inhibitor.
Neuralgia
Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway.
Neuralgia
Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis.
Neuralgia
Reactive oxygen species contribute to neuropathic pain and locomotor dysfunction via activation of CamKII in remote segments following spinal cord contusion injury in rats.
Neuralgia
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.
Neuralgia
Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat.
Neuralgia
Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.
Neuralgia
Silencing of spinal Trpv1 attenuates neuropathic pain in rats by inhibiting CAMKII expression and ERK2 phosphorylation.
Neuralgia
Spinal astrocytic c-Jun N-terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies.
Neuralgia
The 5-HT6 Receptors in the Ventrolateral Orbital Cortex Attenuate Allodynia in a Rodent Model of Neuropathic Pain.
Neuralgia
The Anxiolytic and Antidepressant Effects of Diallyl Disulfide and GYY4137 in Animals with Chronic Neuropathic Pain.
Neuralgia
The dopamine D1-D2DR complex in the rat spinal cord promotes neuropathic pain by increasing neuronal excitability after chronic constriction injury.
Neuralgia
The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development.
Neuralgia
The plasticity of the association between mu-opioid receptor and glutamate ionotropic receptor N in opioid analgesic tolerance and neuropathic pain.
Neuralgia
The Red Nucleus TNF-? Participates in the Initiation and Maintenance of Neuropathic Pain Through Different Signaling Pathways.
Neuralgia
The role of CaMKII in Neuropathic Pain and Fear Memory in Chronic Constriction Injury in Rats.
Neuralgia
Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated.
Neuralgia
Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain.
Neuralgia
[Effect of Electroacupuncture of "Weizhong" (BL 40) and "Huantiao" (GB 30) on cAMP-PKA-CREB Signaling of Spinal Cord in Rats with Neuropathic Pain].
Neuralgia
[Vascular endothelial growth factor antibody attenuates diabetic peripheral neuropathic pain in rats].
Neurilemmoma
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Neurilemmoma
Expression of c-Jun and Sox-2 in human schwannomas and traumatic neuromas.
Neurilemmoma
Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.
Neurilemmoma
Melanotic Schwannoma of the Vulva: A Case Report and Review of the Literature.
Neurilemmoma
Primary intraosseous melanotic schwannoma of the fibula associated with the Carney complex.
Neurilemmoma
Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.
Neurilemmoma
Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.
Neuroaxonal Dystrophies
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Neuroblastoma
68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment.
Neuroblastoma
9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma.
Neuroblastoma
?-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives.
Neuroblastoma
?-N-methylamino-L-alanine induces changes in both GSK3 and TDP-43 in human neuroblastoma.
Neuroblastoma
?-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells.
Neuroblastoma
A casein kinase II-related activity is involved in phosphorylation of microtubule-associated protein MAP-1B during neuroblastoma cell differentiation.
Neuroblastoma
A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins.
Neuroblastoma
A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286.
Neuroblastoma
A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase.
Neuroblastoma
A?-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and A? Secretion in Neural Cells.
Neuroblastoma
Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project.
Neuroblastoma
Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Activation of Ca2+/calmodulin-dependent protein kinase II by stimulation with bradykinin in neuroblastoma x glioma hybrid NG108-15 cells.
Neuroblastoma
Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF.
Neuroblastoma
Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease.
Neuroblastoma
Active c-jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3beta is required for tau aggregation.
Neuroblastoma
Alisertib Combined with Chemotherapy Achieves Response in Neuroblastoma.
Neuroblastoma
ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156.
Neuroblastoma
Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells.
Neuroblastoma
Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro.
Neuroblastoma
Apolipoprotein E and beta-amyloid (1-42) regulation of glycogen synthase kinase-3beta.
Neuroblastoma
Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer.
Neuroblastoma
Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism.
Neuroblastoma
Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma.
Neuroblastoma
Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.
Neuroblastoma
BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.
Neuroblastoma
BCL-2 and Aurora A Inhibitors Suppress MYCN-Amplified Neuroblastomas.
Neuroblastoma
Bcl-xL-mediated antioxidant function abrogates the disruption of mitochondrial dynamics induced by LRRK2 inhibition.
Neuroblastoma
Biological Activity of a Thiobarbituric Acid Compound in Neuroblastomas.
Neuroblastoma
Calcineurin dephosphorylates glycogen synthase kinase-3 beta at serine-9 in neuroblast-derived cells.
Neuroblastoma
CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation.
Neuroblastoma
Casein kinase ii (protein kinase ck2) regulates serotonin 5-ht(3) receptor channel function in ng108-15 cells.
Neuroblastoma
Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death.
Neuroblastoma
Complexes formed with integrin-?5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling.
Neuroblastoma
Computational algorithms for in silico profiling of activating mutations in cancer.
Neuroblastoma
Consistency and reproducibility of next-generation sequencing and other multigene mutational assays: A worldwide ring trial study on quantitative cytological molecular reference specimens.
Neuroblastoma
CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium.
Neuroblastoma
Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells.
Neuroblastoma
Cyclic nucleotide-dependent protein kinase activity in malignant and cyclic AMP-induced "differentiated" neuroblastoma cells in culture.
Neuroblastoma
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Neuroblastoma
Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition.
Neuroblastoma
Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells.
Neuroblastoma
Depletion of catalytic and regulatory subunits of protein kinase CK2 by antisense oligonucleotide treatment of neuroblastoma cells.
Neuroblastoma
Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-SY5Y cells.
Neuroblastoma
Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation.
Neuroblastoma
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis.
Neuroblastoma
DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
Neuroblastoma
Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation.
Neuroblastoma
Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.
Neuroblastoma
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.
Neuroblastoma
Downregulation of glycogen synthase kinase-3beta (GSK-3beta) protein expression during neuroblastoma IMR-32 cell differentiation.
Neuroblastoma
Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans.
Neuroblastoma
E6-Associated Protein Dependent Estrogen Receptor Regulation of Protein Kinase A Regulatory Subunit R2A Expression in Neuroblastoma.
Neuroblastoma
Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Neuroblastoma
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Neuroblastoma
Functional properties of LRRK2 mutations in Taiwanese Parkinson disease.
Neuroblastoma
G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.
Neuroblastoma
Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells.
Neuroblastoma
GD2 ganglioside-binding antibody 14G2a and specific aurora A kinase inhibitor MK-5108 induce autophagy in IMR-32 neuroblastoma cells.
Neuroblastoma
GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN.
Neuroblastoma
Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas.
Neuroblastoma
Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease.
Neuroblastoma
Glia maturation factor overexpression in neuroblastoma cells activates glycogen synthase kinase-3beta and caspase-3.
Neuroblastoma
Glycogen synthase kinase-3 (GSK3) controls deoxyglucose-induced mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells.
Neuroblastoma
Glycogen synthase kinase-3 and Axin function in a beta-catenin-independent pathway that regulates neurite outgrowth in neuroblastoma cells.
Neuroblastoma
Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium.
Neuroblastoma
GSK-3 mediates the okadaic acid-induced modification of collapsin response mediator protein-2 in human SK-N-SH neuroblastoma cells.
Neuroblastoma
GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells.
Neuroblastoma
Herpes simplex virus type 1 latency-associated transcript inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels.
Neuroblastoma
Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/?-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes.
Neuroblastoma
Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.
Neuroblastoma
Identification of ULK1 as a novel biomarker involved in miR-4487 and miR-595 regulation in neuroblastoma SH-SY5Y cell autophagy.
Neuroblastoma
Identification of unique heterozygous germline mutation, STK11 (p.F354L), in a child with encapsulated follicular variant of papillary thyroid carcinoma within 6 months of completing treatment for neuroblastoma.
Neuroblastoma
Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells.
Neuroblastoma
Inactivation of glycogen synthase kinase-3beta contributes to brain-derived neutrophic factor/TrkB-induced resistance to chemotherapy in neuroblastoma cells.
Neuroblastoma
Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3beta in N1E-115 neuroblastoma cells.
Neuroblastoma
Increase in cytoplasmic casein kinase II-type activity accompanies neurite outgrowth after DNA synthesis inhibition in NIA-103 neuroblastoma cells.
Neuroblastoma
Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells.
Neuroblastoma
Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells.
Neuroblastoma
Inhibition of neurite outgrowth in murine neuroblastoma NS-20Y cells by calmodulin inhibitors.
Neuroblastoma
Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4.
Neuroblastoma
Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors.
Neuroblastoma
Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma.
Neuroblastoma
Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappaB in cellular models of Parkinson's disease.
Neuroblastoma
Interaction between 14-3-3? and PrP influences the dimerization of 14-3-3 and fibrillization of PrP106-126.
Neuroblastoma
Interactions Between Glycogen Synthase Kinase 3beta, Protein Kinase B, and Protein Phosphatase 2A in Tau Phosphorylation in Mouse N2a Neuroblastoma Cells.
Neuroblastoma
Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells.
Neuroblastoma
Involvement of GSK-3beta in TWEAK-mediated NF-kappaB activation.
Neuroblastoma
JNK phosphorylation of paxillin, acting through the Rac1 and Cdc42 signaling cascade, mediates neurite extension in N1E-115 cells.
Neuroblastoma
Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease.
Neuroblastoma
Lithium induces morphological differentiation of mouse neuroblastoma cells.
Neuroblastoma
Long Non-coding RNA HOTAIR Promotes Parkinson's Disease Induced by MPTP Through up-regulating the Expression of LRRK2.
Neuroblastoma
LRRK2 expression in normal and pathologic human brain and in human cell lines.
Neuroblastoma
LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4.
Neuroblastoma
MAST1 modulates neuronal differentiation and cell cycle exit via P27 in neuroblastoma cells.
Neuroblastoma
Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells.
Neuroblastoma
MEK/ERKs signaling is essential for lithium-induced neurite outgrowth in N2a cells.
Neuroblastoma
Melanocytic nevi excised during B-Raf proto-oncogene (BRAF) inhibitor therapy: A study of 19 lesions from 10 patients.
Neuroblastoma
Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells.
Neuroblastoma
MicroRNA-145 suppresses uveal melanoma angiogenesis and growth by targeting neuroblastoma RAS viral oncogene homolog and vascular endothelial growth factor.
Neuroblastoma
MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2.
Neuroblastoma
Microtubule protein phosphorylation in neuroblastoma cells and neurite growth.
Neuroblastoma
miR-506 suppresses neuroblastoma metastasis by targeting ROCK1.
Neuroblastoma
MiRNA-335 Suppresses Neuroblastoma Cell Invasiveness By Direct Targeting of Multiple Genes from the non-Canonical TGF-? Signalling Pathway.
Neuroblastoma
Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome.
Neuroblastoma
Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells.
Neuroblastoma
Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille's heel to be exploited for the therapy of MYCN-amplified neuroblastoma.
Neuroblastoma
Mutational analysis of the RAS/RAF/MEK/ERK signaling pathway in 260 Han Chinese patients with cervical carcinoma.
Neuroblastoma
MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.
Neuroblastoma
Neurite outgrowth of neuroblastoma cells overexpressing alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II-effects of protein kinase inhibitors.
Neuroblastoma
Neurofibromatosis 2 tumor suppressor, the gene induced by valproic acid, mediates neurite outgrowth through interaction with paxillin.
Neuroblastoma
Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.
Neuroblastoma
Oestradiol regulates ?-catenin-mediated transcription in neurones.
Neuroblastoma
Overexpression of alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II in neuroblastoma cells -- H-7 promotes neurite outgrowth.
Neuroblastoma
Overexpression of Ca2+/calmodulin-dependent protein kinase II in Neuro2a and NG108-15 neuroblastoma cell lines promotes neurite outgrowth and growth cone motility.
Neuroblastoma
Overexpression of RII beta regulatory subunit of protein kinase A induces growth inhibition and reverse-transformation in SK-N-SH human neuroblastoma cells.
Neuroblastoma
PACAP action in nervous system development, regeneration, and neuroblastoma cell proliferation.
Neuroblastoma
Parkin attenuates wild-type tau modification in the presence of beta-amyloid and alpha-synuclein.
Neuroblastoma
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Neuroblastoma
Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Peptides derived from the knuckle epitope of BMP-9 induce the cholinergic differentiation and inactivate GSk3beta in human SH-SY5Y neuroblastoma cells.
Neuroblastoma
Perampanel Inhibits Neuroblastoma Cell Proliferation Through Down-regulation of AKT and ERK Pathways.
Neuroblastoma
Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial.
Neuroblastoma
Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells.
Neuroblastoma
Phosphatidylinositol 3-kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells.
Neuroblastoma
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
Neuroblastoma
Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells.
Neuroblastoma
Phosphorylation of microtubule-associated proteins by protein kinase CK2 in neuritogenesis.
Neuroblastoma
Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells.
Neuroblastoma
Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1? Triggers Mislocalization and Accumulation of TDP-43.
Neuroblastoma
Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3.
Neuroblastoma
Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells.
Neuroblastoma
Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element.
Neuroblastoma
Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition.
Neuroblastoma
Proteomics of dedifferentiation of SK-N-BE2 neuroblastoma cells.
Neuroblastoma
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.
Neuroblastoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Neuroblastoma
Raf kinase inhibitor protein enhances neuronal differentiation in human SH-SY5Y cells.
Neuroblastoma
Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium.
Neuroblastoma
Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function.
Neuroblastoma
Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.
Neuroblastoma
Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells.
Neuroblastoma
Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators.
Neuroblastoma
RET protein promotes non-adherent growth of NB-39-nu neuroblastoma cell line.
Neuroblastoma
Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.
Neuroblastoma
Rho-associated kinase is a therapeutic target in neuroblastoma.
Neuroblastoma
RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player.
Neuroblastoma
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma.
Neuroblastoma
RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model.
Neuroblastoma
Role of phosphorylated MAPlB in neuritogenesis.
Neuroblastoma
Salsolinol, an endogenous neurotoxin, activates JNK and NF-kappaB signaling pathways in human neuroblastoma cells.
Neuroblastoma
Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer.
Neuroblastoma
Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines.
Neuroblastoma
Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.
Neuroblastoma
Significance of tau phosphorylation and protein kinase regulation in the pathogenesis of Alzheimer disease.
Neuroblastoma
SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase.
Neuroblastoma
Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line.
Neuroblastoma
Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth.
Neuroblastoma
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma.
Neuroblastoma
Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.
Neuroblastoma
Targeting aurora kinase A inhibits hypoxia-mediated neuroblastoma cell tumorigenesis.
Neuroblastoma
Targeting GD2 ganglioside and aurora A kinase as a dual strategy leading to cell death in cultures of human neuroblastoma cells.
Neuroblastoma
The Amino Terminus of Herpes Simplex Virus 1 Glycoprotein K (gK) Is Required for gB Binding to Akt, Release of Intracellular Calcium, and Fusion of the Viral Envelope with Plasma Membranes.
Neuroblastoma
The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma.
Neuroblastoma
The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells.
Neuroblastoma
The effects of clozapine on the GSK-3-mediated signaling pathway.
Neuroblastoma
The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.
Neuroblastoma
The interrelationship between selective tau phosphorylation and microtubule association.
Neuroblastoma
The long noncoding RNA HOTAIR promotes Parkinson's disease by upregulating LRRK2 expression.
Neuroblastoma
The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.
Neuroblastoma
The MYCN protein of human neuroblastoma cells is phosphorylated by casein kinase II in the central region and at serine 367.
Neuroblastoma
The specific Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells.
Neuroblastoma
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.
Neuroblastoma
Tubulin phosphorylation by casein kinase II is similar to that found in vivo.
Neuroblastoma
Type II protein kinase A up-regulation is sufficient to induce growth inhibition in SK-N-SH human neuroblastoma cells.
Neuroblastoma
UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines.
Neuroblastoma
Unholy matrimony: Aurora A and N-Myc as malignant partners in neuroblastoma.
Neuroblastoma
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease.
Neuroblastoma
Vitronectin regulates the axon specification of mouse cerebellar granule cell precursors via ?v?5 integrin in the differentiation stage.
Neuroblastoma
Zyxin is a novel target for beta-amyloid peptide: characterization of its role in Alzheimer's pathogenesis.
Neuroblastoma
[Cellular reactions after stimulation of receptors: research model for evaluation of effects and action mechanisms of drugs for discovery of innovative drugs]
Neuroblastoma
[Protective effect of BAG-1L mediated by lentivirus in human neuroblastoma cells induced by hypoxia].
Neuroblastoma
[The stimulation of glutamate uptake by the phorbol ester in rat cerebral cortex synaptosomes and cell line of human anaplastic astrocytoma BT-325]
Neuroblastoma
[The temperature dependence of protein kinase A and C activity in variant mouse neuroblastoma cells differing genetically in their heat resistance]
Neurodegenerative Diseases
"Jnking" atherosclerosis.
Neurodegenerative Diseases
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.
Neurodegenerative Diseases
14-3-3 and aggresome formation: implications in neurodegenerative diseases.
Neurodegenerative Diseases
14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes.
Neurodegenerative Diseases
14-3-3 protein, total tau and phosphorylated tau in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease and neurodegenerative disease in Japan.
Neurodegenerative Diseases
14-3-3 proteins and regulation of cytoskeleton.
Neurodegenerative Diseases
14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease.
Neurodegenerative Diseases
14-3-3 proteins in neurodegeneration.
Neurodegenerative Diseases
14-3-3 Proteins in the Regulation of Rotenone-Induced Neurotoxicity Might be via Its Isoform 14-3-3Epsilon's Involvement in Autophagy.
Neurodegenerative Diseases
14-3-3 proteins: an important regulator of autophagy in diseases.
Neurodegenerative Diseases
14-3-3 Proteins: Novel Pharmacological Targets in Neurodegenerative Diseases.
Neurodegenerative Diseases
5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.
Neurodegenerative Diseases
?-N-methylamino-L-alanine induces changes in both GSK3 and TDP-43 in human neuroblastoma.
Neurodegenerative Diseases
A comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism.
Neurodegenerative Diseases
A homogenous luminescent proximity assay for 14-3-3 interactions with both phosphorylated and nonphosphorylated client peptides.
Neurodegenerative Diseases
A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286.
Neurodegenerative Diseases
A natural product from Cannabis sativa subsp. sativa inhibits homeodomain-interacting protein kinase 2 (HIPK2), attenuating MPP
Neurodegenerative Diseases
A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.
Neurodegenerative Diseases
A pivotal role of GSK-3 in synaptic plasticity.
Neurodegenerative Diseases
A polymorphism in the YWHAH gene encoding 14-3-3 eta that is not associated with sporadic Creutzfeldt-Jakob disease (CJD).
Neurodegenerative Diseases
A unique type of GSK-3 inhibitor brings new opportunities to the clinic.
Neurodegenerative Diseases
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Neurodegenerative Diseases
Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid.
Neurodegenerative Diseases
Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice.
Neurodegenerative Diseases
Age-related changes in glycogen synthase kinase 3beta (GSK3beta) immunoreactivity in the central nervous system of rats.
Neurodegenerative Diseases
Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels.
Neurodegenerative Diseases
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Neurodegenerative Diseases
An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders.
Neurodegenerative Diseases
Analysis of Cell-type Specific Expression of CK1{varepsilon} in Various Tissues of Young Adult BALB/c Mice and in Mammary Tumors of SV40 T-Ag Transgenic Mice.
Neurodegenerative Diseases
Anti-inflammatory Potential of GSK-3 Inhibitors.
Neurodegenerative Diseases
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.
Neurodegenerative Diseases
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.
Neurodegenerative Diseases
ATM-Dependent Phosphorylation of MEF2D Promotes Neuronal Survival after DNA Damage.
Neurodegenerative Diseases
Autopsy-diagnosed neurodegenerative dementia cases support the use of cerebrospinal fluid protein biomarkers in the diagnostic work-up.
Neurodegenerative Diseases
Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction.
Neurodegenerative Diseases
Bi-directional genetic modulation of GSK-3? exacerbates hippocampal neuropathology in experimental status epilepticus.
Neurodegenerative Diseases
Binge Alcohol Exposure Causes Neurobehavioral Deficits and GSK3? Activation in the Hippocampus of Adolescent Rats.
Neurodegenerative Diseases
Callyspongisines A-D: bromopyrrole alkaloids from an Australian marine sponge, Callyspongia sp.
Neurodegenerative Diseases
Calpain-mediated truncation of GSK-3 in post-mortem brain samples.
Neurodegenerative Diseases
CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death.
Neurodegenerative Diseases
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Neurodegenerative Diseases
Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer's disease brain.
Neurodegenerative Diseases
Cdk5 Contributes to Huntington's Disease Learning and Memory Deficits via Modulation of Brain Region-Specific Substrates.
Neurodegenerative Diseases
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease.
Neurodegenerative Diseases
Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways.
Neurodegenerative Diseases
Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years.
Neurodegenerative Diseases
Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02.
Neurodegenerative Diseases
CK1? kinase activity is modulated by Chk1-mediated phosphorylation.
Neurodegenerative Diseases
Cleavage of GSK-3? by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3? activity induced by H?O?.
Neurodegenerative Diseases
Clinical heterogeneity of LRRK2 p.I2012T mutation.
Neurodegenerative Diseases
Co-occurrence of sporadic parkinsonism and late-onset Alzheimer's disease in a Brazilian male with the LRRK2 p.G2019S mutation.
Neurodegenerative Diseases
Cognitive enhancement, TAU phosphorylation reduction, and neuronal protection by the treatment of an LRRK2 inhibitor in a tauopathy mouse model.
Neurodegenerative Diseases
Comparative virtual and experimental high-throughput screening for glycogen synthase kinase-3beta inhibitors.
Neurodegenerative Diseases
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3.
Neurodegenerative Diseases
Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase.
Neurodegenerative Diseases
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Neurodegenerative Diseases
Crowded, Cell-like Environment Accelerates the Nucleation Step of Amyloidogenic Protein Misfolding.
Neurodegenerative Diseases
Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells.
Neurodegenerative Diseases
Curcumin: from food spice to cancer prevention.
Neurodegenerative Diseases
Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons.
Neurodegenerative Diseases
Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation.
Neurodegenerative Diseases
Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease.
Neurodegenerative Diseases
Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.
Neurodegenerative Diseases
Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.
Neurodegenerative Diseases
Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.
Neurodegenerative Diseases
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Neurodegenerative Diseases
Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Neurodegenerative Diseases
Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2?/CK2? interaction.
Neurodegenerative Diseases
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation.
Neurodegenerative Diseases
Differential Expression of Small Heat Shock Protein 27 (Hsp27) in Ataxia telangiectasia Brains.
Neurodegenerative Diseases
Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.
Neurodegenerative Diseases
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Neurodegenerative Diseases
DNA damage responses in neural cells: Focus on the telomere.
Neurodegenerative Diseases
Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons.
Neurodegenerative Diseases
Downregulation of 14-3-3 Proteins in Alzheimer's Disease.
Neurodegenerative Diseases
Driving neural regeneration through the mammalian target of rapamycin.
Neurodegenerative Diseases
Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.
Neurodegenerative Diseases
Effect of Class Switch Recombination Defect on the Phenotype of Ataxia-Telangiectasia Patients.
Neurodegenerative Diseases
Efficient allele-specific targeting of LRRK2 R1441 mutations mediated by RNAi.
Neurodegenerative Diseases
Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration.
Neurodegenerative Diseases
Elucidation of Dietary Polyphenolics as Potential Inhibitor of Microtubule Affinity Regulating Kinase 4: In silico and In vitro Studies.
Neurodegenerative Diseases
Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO.
Neurodegenerative Diseases
Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3.
Neurodegenerative Diseases
Epigenetic Control of Rho-Associated Protein Kinase 2 in Neurodegeneration.
Neurodegenerative Diseases
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells.
Neurodegenerative Diseases
Evolutionary conservation and divergence of the human brain transcriptome.
Neurodegenerative Diseases
Expression of 14-3-3 transcript isoforms in response to ethanol exposure and their regulation by miRNAs.
Neurodegenerative Diseases
Expression of 14-3-3 Zeta Protein in Dexamethasone-Treated Mice and Human TM-1 Cells.
Neurodegenerative Diseases
Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection.
Neurodegenerative Diseases
Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation.
Neurodegenerative Diseases
Genetic Variants Associated With Neurodegenerative Diseases Regulate Gene Expression in Immune Cell CD14+ Monocytes.
Neurodegenerative Diseases
Genomic Characteristics of Genetic Creutzfeldt-Jakob Disease Patients with V180I Mutation and Associations with Other Neurodegenerative Disorders.
Neurodegenerative Diseases
Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation.
Neurodegenerative Diseases
Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).
Neurodegenerative Diseases
Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.
Neurodegenerative Diseases
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.
Neurodegenerative Diseases
Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death.
Neurodegenerative Diseases
Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes.
Neurodegenerative Diseases
Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.
Neurodegenerative Diseases
Glycogen synthase kinase-3 (GSK-3) inhibitors reach the clinic.
Neurodegenerative Diseases
Glycogen synthase kinase-3 - a promising therapeutic target: Dr Hagit Eldar-Finkelman interviewed by Emma Quigley.
Neurodegenerative Diseases
Glycogen synthase kinase-3 beta (GSK-3?) signaling: Implications for Parkinson's disease.
Neurodegenerative Diseases
Glycogen synthase kinase-3 reduces acetylcholine level in striatum via disturbing cellular distribution of choline acetyltransferase in cholinergic interneurons in rats.
Neurodegenerative Diseases
Glycogen synthase kinase-3--an overview of an over-achieving protein kinase.
Neurodegenerative Diseases
Glycogen synthase kinase-3beta activity plays very important roles in determining the fate of oxidative stress-inflicted neuronal cells.
Neurodegenerative Diseases
Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.
Neurodegenerative Diseases
GSK-3 and Tau: A Key Duet in Alzheimer's Disease.
Neurodegenerative Diseases
GSK-3 in Neurodegenerative Diseases.
Neurodegenerative Diseases
GSK-3 Inhibitors: From the Brain to the Retina and Back Again.
Neurodegenerative Diseases
GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration.
Neurodegenerative Diseases
GSK-3beta and oxidative stress in aged brain. Role of poly(ADP- -ribose) polymerase-1.
Neurodegenerative Diseases
GSK-3beta is required for memory reconsolidation in adult brain.
Neurodegenerative Diseases
GSK-3beta phosphorylation of functionally distinct tau isoforms has differential, but mild effects.
Neurodegenerative Diseases
GSK3B and MAPT Polymorphisms Are Associated with Grey Matter and Intracranial Volume in Healthy Individuals.
Neurodegenerative Diseases
GSK3beta signalling: casting a wide net in Alzheimer's disease.
Neurodegenerative Diseases
HDAC6 regulates mitochondrial transport in hippocampal neurons.
Neurodegenerative Diseases
Health risks for ataxia-telangiectasia mutated heterozygotes: A systematic review, Meta-analysis and evidence-based guideline.
Neurodegenerative Diseases
Highlighting the protective or degenerative role of AMPK activators in dementia experimental models.
Neurodegenerative Diseases
Highly Potent and Specific GSK-3beta Inhibitors That Block Tau Phosphorylation and Decrease alpha-Synuclein Protein Expression in a Cellular Model of Parkinson's Disease.
Neurodegenerative Diseases
Hippocampal neuronal death induced by kainic acid and restraint stress is suppressed by exercise.
Neurodegenerative Diseases
Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia.
Neurodegenerative Diseases
Hypothesis: JNK signaling is a therapeutic target of neurodegenerative diseases.
Neurodegenerative Diseases
Identification and characterization of PKC?, a kinase associated with SCA14, as an amyloidogenic protein.
Neurodegenerative Diseases
Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening.
Neurodegenerative Diseases
Identification of Natural Compounds against Neurodegenerative Diseases Using In Silico Techniques.
Neurodegenerative Diseases
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3? inhibitors through virtual screening.
Neurodegenerative Diseases
Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.
Neurodegenerative Diseases
Immunolocalization of CaMKII and NR2B in hippocampal subregions of rat during postnatal development.
Neurodegenerative Diseases
Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity.
Neurodegenerative Diseases
Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat.
Neurodegenerative Diseases
Inhibitory effect of alpha-lipoic acid on mitochondrial dysfunction and interleukin-8 expression in interleukin-1beta-stimulated ataxia teleangiectasia fibroblasts.
Neurodegenerative Diseases
Interactions of CaMKII with dopamine D2 receptors: roles in levodopa-induced dyskinesia in 6-hydroxydopamine lesioned Parkinson's rats.
Neurodegenerative Diseases
Interactive Association Between Intronic Polymorphism (rs10506151) of the LRRK2 Gene and Type 2 Diabetes on Neurodegenerative Diseases.
Neurodegenerative Diseases
Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.
Neurodegenerative Diseases
Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor.
Neurodegenerative Diseases
Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
Neurodegenerative Diseases
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Neurodegenerative Diseases
Kinase inhibitor scaffolds against neurodegenerative diseases from a Southern Australian ascidian, Didemnum sp.
Neurodegenerative Diseases
Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3?.
Neurodegenerative Diseases
Lithium and Neuropsychiatric Therapeutics: Neuroplasticity via Glycogen Synthase Kinase-3beta, beta-Catenin, and Neurotrophin Cascades.
Neurodegenerative Diseases
Lithium fails to protect dopaminergic neurons in the 6-OHDA model of Parkinson's disease.
Neurodegenerative Diseases
Lithium Inhibits GSK3? and Augments GluN2A Receptor Expression in the Prefrontal Cortex.
Neurodegenerative Diseases
Lithium Reduces BACE1 Overexpression, Beta Amyloid Accumulation, and Spatial Learning Deficits in Mice with Traumatic Brain Injury.
Neurodegenerative Diseases
Lithium treatment decreases activities of tau kinases in a murine model of senescence.
Neurodegenerative Diseases
Lithium: bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium.
Neurodegenerative Diseases
Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.
Neurodegenerative Diseases
Loss of function of Ywhah in mice induces deafness and cochlear outer hair cells' degeneration.
Neurodegenerative Diseases
Loss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice.
Neurodegenerative Diseases
Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation.
Neurodegenerative Diseases
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.
Neurodegenerative Diseases
LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons.
Neurodegenerative Diseases
LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia.
Neurodegenerative Diseases
LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction.
Neurodegenerative Diseases
LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Neurodegenerative Diseases
LRRK2 p.G2019S mutation is not common among Alzheimer's disease patients in Brazil.
Neurodegenerative Diseases
Mammalian STE20-like Kinase 1 Knockdown Attenuates TNF?-Mediated Neurodegenerative Disease by Repressing the JNK Pathway and Mitochondrial Stress.
Neurodegenerative Diseases
Map kinase signaling as therapeutic target for neurodegeneration.
Neurodegenerative Diseases
MAP1B rescues LRRK2 mutant-mediated cytotoxicity.
Neurodegenerative Diseases
Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration.
Neurodegenerative Diseases
Memantine Inhibits Calpain-Mediated Truncation of GSK-3 Induced by NMDA: Implications in Alzheimer's Disease.
Neurodegenerative Diseases
Meridianins and Lignarenone B as Potential GSK3? Inhibitors and Inductors of Structural Neuronal Plasticity.
Neurodegenerative Diseases
Mitochondrial dysfunction and apoptosis are attenuated through activation of AMPK/GSK-3?/PP2A pathway in Parkinson's disease.
Neurodegenerative Diseases
Mixed-lineage kinases: a target for the prevention of neurodegeneration.
Neurodegenerative Diseases
Molecular genetic findings in LRRK2 American, Canadian and German families.
Neurodegenerative Diseases
Monitoring 14-3-3 protein interactions with a homogeneous fluorescence polarization assay.
Neurodegenerative Diseases
Multiplying Messages LRRK beneath Parkinson Disease.
Neurodegenerative Diseases
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.
Neurodegenerative Diseases
Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C.
Neurodegenerative Diseases
Neurodegenerative disease: microRNAs under threat from LRRK2.
Neurodegenerative Diseases
Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways.
Neurodegenerative Diseases
Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease.
Neurodegenerative Diseases
Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons.
Neurodegenerative Diseases
Neuroprotective effects of Tiaogeng decoction against H2O2-induced oxidative injury and apoptosis in PC12 cells via Nrf2 and JNK signaling pathways.
Neurodegenerative Diseases
Neuroprotective function of 14-3-3 proteins in neurodegeneration.
Neurodegenerative Diseases
New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.
Neurodegenerative Diseases
New leads for selective GSK-3 inhibition: pharmacophore mapping and virtual screening studies.
Neurodegenerative Diseases
New perspective on the dual functions of indirubins in cancer therapy and neuroprotection.
Neurodegenerative Diseases
Non-motor symptoms in Chinese Parkinson's disease patients with and without LRRK2 G2385R and R1628P variants.
Neurodegenerative Diseases
Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease.
Neurodegenerative Diseases
Novel compounds for the modulation of mTOR and autophagy to treat neurodegenerative diseases.
Neurodegenerative Diseases
Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
Neurodegenerative Diseases
Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer's disease and cerebral amyloid angiopathy.
Neurodegenerative Diseases
Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics.
Neurodegenerative Diseases
Pathogenic Lrrk2 substitutions and Amyotrophic lateral sclerosis.
Neurodegenerative Diseases
Pharmacological inhibitors of glycogen synthase kinase 3.
Neurodegenerative Diseases
Pharmacophore feature-based virtual screening for finding potent GSK-3 inhibitors using molecular docking and dynamics simulations.
Neurodegenerative Diseases
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.
Neurodegenerative Diseases
Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death.
Neurodegenerative Diseases
Possible role of the glycogen synthase kinase-3 signaling pathway in trimethyltin-induced hippocampal neurodegeneration in mice.
Neurodegenerative Diseases
Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury.
Neurodegenerative Diseases
Potential mechanisms involved in the prevention of neurodegenerative diseases by lithium.
Neurodegenerative Diseases
Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma.
Neurodegenerative Diseases
PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.
Neurodegenerative Diseases
Progressive hind limb paralysis in mice carrying a v-Mos transgene.
Neurodegenerative Diseases
Proteinase-activated receptor 2 and disease biomarkers in cerebrospinal fluid in cases with autopsy-confirmed prion diseases and other neurodegenerative diseases.
Neurodegenerative Diseases
Proteomic analysis of 14-3-3 zeta binding proteins in the mouse hippocampus.
Neurodegenerative Diseases
PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies.
Neurodegenerative Diseases
Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease.
Neurodegenerative Diseases
Raf-1 Kinase Inhibitory Protein (RKIP) Promotes Retinal Ganglion Cell Survival and Axonal Regeneration Following Optic Nerve Crush.
Neurodegenerative Diseases
Regulation of GSK-3beta by calpain in the 3-nitropropionic acid model.
Neurodegenerative Diseases
Regulation of LRRK2 expression points to a functional role in human monocyte maturation.
Neurodegenerative Diseases
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention.
Neurodegenerative Diseases
Regulatory roles of JNK in programmed cell death.
Neurodegenerative Diseases
Resveratrol Inhibits Venezuelan Equine Encephalitis Virus Infection by Interfering with the AKT/GSK Pathway.
Neurodegenerative Diseases
Revisiting the Proposition of Binding Pockets and Bioactive Poses for GSK-3? Allosteric Modulators Addressed to Neurodegenerative Diseases.
Neurodegenerative Diseases
Role of GSK-3beta activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene.
Neurodegenerative Diseases
Role of protein kinase A in regulating mitochondrial function and neuronal development: implications to neurodegenerative diseases.
Neurodegenerative Diseases
Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons.
Neurodegenerative Diseases
SARS-CoV-2 dysregulation of PTBP1 and YWHAE/Z gene expression: A primer of neurodegeneration.
Neurodegenerative Diseases
Science Signaling Podcast for 15 November 2016: A new type of kinase inhibitor.
Neurodegenerative Diseases
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Neurodegenerative Diseases
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
Neurodegenerative Diseases
Small molecules modulation of 14-3-3 protein-protein interactions.
Neurodegenerative Diseases
Specific 14-3-3 isoform detection and immunolocalization in prion diseases.
Neurodegenerative Diseases
Staurosporine-induced apoptosis in astrocytes is prevented by A1 adenosine receptor activation.
Neurodegenerative Diseases
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Neurodegenerative Diseases
Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors.
Neurodegenerative Diseases
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: an update.
Neurodegenerative Diseases
Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.
Neurodegenerative Diseases
Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors.
Neurodegenerative Diseases
Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of ?-secretase (BACE1).
Neurodegenerative Diseases
Synthesis and biological evaluation of novel 5,6-dihydropyrimido[4,5-f]quinazoline derivatives as potent CDK2 inhibitors.
Neurodegenerative Diseases
Synthesis of pyrimidin-4-one-1,2,3-triazole conjugates as glycogen synthase kinase-3? inhibitors with anti-depressant activity.
Neurodegenerative Diseases
Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging.
Neurodegenerative Diseases
Targeting leucine-rich repeat kinase 2 in Parkinson's disease.
Neurodegenerative Diseases
Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders.
Neurodegenerative Diseases
Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors.
Neurodegenerative Diseases
The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats.
Neurodegenerative Diseases
The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease.
Neurodegenerative Diseases
The GSK3 beta signaling cascade and neurodegenerative disease.
Neurodegenerative Diseases
The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides.
Neurodegenerative Diseases
The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.
Neurodegenerative Diseases
The lrrk2 p.Gly2019Ser mutation is uncommon in a Danish cohort with various neurodegenerative disorders.
Neurodegenerative Diseases
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
Neurodegenerative Diseases
The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.
Neurodegenerative Diseases
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules.
Neurodegenerative Diseases
The role of protein disorder in the 14-3-3 interaction network.
Neurodegenerative Diseases
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Neurodegenerative Diseases
The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation.
Neurodegenerative Diseases
The synaptic function of LRRK2.
Neurodegenerative Diseases
The Wnt signaling pathway in bipolar disorder.
Neurodegenerative Diseases
The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress.
Neurodegenerative Diseases
Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation.
Neurodegenerative Diseases
TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2.
Neurodegenerative Diseases
Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes.
Neurodegenerative Diseases
[A new target for diabetes therapy: advances in the research of glycogen synthase kinase-3 inhibitors]
Neurodegenerative Diseases
[Clinical molecular genetics for PARK8 (LRRK2)]
Neurodegenerative Diseases
[The role of lithium in neurodegenerative diseases: new registries for old actors.]
Neuroectodermal Tumors
Upregulation of Ku expression in human neuroectodermal tumor cells after retroviral DNA integration.
Neuroectodermal Tumors, Primitive
PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors.
Neuroectodermal Tumors, Primitive
STK33 promotes the growth and progression of human pancreatic neuroendocrine tumour via activation of the PI3K/AKT/mTOR pathway.
Neuroectodermal Tumors, Primitive, Peripheral
Interaction between ERK and GSK3{beta} Mediates Basic Fibroblast Growth Factor-induced Apoptosis in SK-N-MC Neuroblastoma Cells.
Neuroendocrine Tumors
Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors.
Neuroendocrine Tumors
Current treatment options for neuroendocrine tumors.
Neuroendocrine Tumors
Expression of p-AKT and p-mTOR in a large series of bronchopulmonary neuroendocrine tumors.
Neuroendocrine Tumors
Growth factor receptor expression in human gastroenteropancreatic neuroendocrine tumours.
Neuroendocrine Tumors
Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells.
Neuroendocrine Tumors
Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target.
Neuroendocrine Tumors
Rho-kinase inhibition by Fasudil promotes tumor maturation and apoptosis in small-cell lung cancer.
Neuroendocrine Tumors
STK33 promotes the growth and progression of human pancreatic neuroendocrine tumour via activation of the PI3K/AKT/mTOR pathway.
Neurofibromatoses
A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor.
Neurofibromatoses
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
Neurofibromatoses
CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice.
Neurofibromatoses
Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies.
Neurofibromatoses
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Neurofibromatoses
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibromatoses
Pathological classification and molecular genetics of meningiomas.
Neurofibromatoses
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
Neurofibromatoses
Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells.
Neurofibromatoses
Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA.
Neurofibromatoses
Sichuan Pepper Extracts Block the PAK1/Cyclin D1 Pathway and the Growth of NF1-Deficient Cancer Xenograft in Mice.
Neurofibromatoses
Signal Therapy of Breast Cancers by the HDAC Inhibitor FK228 That Blocks the Activation of PAK1 and Abrogates the Tamoxifen-Resistance.
Neurofibromatoses
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).
Neurofibromatosis 1
A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor.
Neurofibromatosis 1
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
Neurofibromatosis 1
CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice.
Neurofibromatosis 1
Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies.
Neurofibromatosis 1
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibromatosis 1
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
Neurofibromatosis 1
Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells.
Neurofibromatosis 1
Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA.
Neurofibromatosis 2
CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice.
Neurofibromatosis 2
Pathological classification and molecular genetics of meningiomas.
Neurofibrosarcoma
Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.
Neurofibrosarcoma
Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.
Neurofibrosarcoma
Potentially useful markers for desmoplastic melanoma: an analysis of KBA.62, p-AKT, and ezrin.
Neurofibrosarcoma
Schwann cell lines derived from malignant peripheral nerve sheath tumors respond abnormally to platelet-derived growth factor-BB.
Neuroinflammatory Diseases
A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease models.
Neuroinflammatory Diseases
A systematic review of molecular approaches that link mitochondrial dysfunction and neuroinflammation in Parkinson's disease.
Neuroinflammatory Diseases
Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
Neuroinflammatory Diseases
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum.
Neuroinflammatory Diseases
Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation.
Neuroinflammatory Diseases
Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation.
Neuroinflammatory Diseases
Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3? Signaling in LPS-Treated Adult Mice.
Neuroinflammatory Diseases
Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in A?1-42-Induced Mice.
Neuroinflammatory Diseases
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Neuroinflammatory Diseases
Caruifolin D from artemisia absinthium L. inhibits neuroinflammation via reactive oxygen species-dependent c-jun N-terminal kinase and protein kinase c/NF-?B signaling pathways.
Neuroinflammatory Diseases
Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF-?B and JNK activations in microglia cells.
Neuroinflammatory Diseases
Cognitive effects of the GSK-3 inhibitor "lithium" in LPS/chronic mild stress rat model of depression: Hippocampal and cortical neuroinflammation and tauopathy.
Neuroinflammatory Diseases
Dietary n-3 PUFA Deficiency Increases Vulnerability to Scopolamine-Induced Cognitive Impairment in Male C57BL/6 Mice.
Neuroinflammatory Diseases
Down-regulation of MST1 in hippocampus protects against stress-induced depression-like behaviours and synaptic plasticity impairments.
Neuroinflammatory Diseases
Effects of paeonol on anti-neuroinflammatory responses in microglial cells.
Neuroinflammatory Diseases
Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO.
Neuroinflammatory Diseases
Endurance Exercise Prevents Metabolic Distress-induced Senescence in the Hippocampus.
Neuroinflammatory Diseases
Expression of microRNA in human retinal pigment epithelial cells following infection with Zaire ebolavirus.
Neuroinflammatory Diseases
G2019s LRRK2 promotes mitochondrial fission and increases TNF?-mediated neuroinflammation responses.
Neuroinflammatory Diseases
Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease.
Neuroinflammatory Diseases
Genetic Imaging of Neuroinflammation in Parkinson's Disease: Recent Advancements.
Neuroinflammatory Diseases
Glycogen synthase kinase-3 beta (GSK-3?) signaling: Implications for Parkinson's disease.
Neuroinflammatory Diseases
GSK-3 mediates the release of IL-1?, TNF-? and IL-10 from cortical glia.
Neuroinflammatory Diseases
Heat shock protein 70 suppresses neuroinflammation induced by ?-synuclein in astrocytes.
Neuroinflammatory Diseases
Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia.
Neuroinflammatory Diseases
In-Silico Screening of Ligand Based Pharmacophore, Database Mining and Molecular Docking on 2, 5-Diaminopyrimidines Azapurines as Potential Inhibitors of Glycogen Synthase Kinase-3?.
Neuroinflammatory Diseases
Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells.
Neuroinflammatory Diseases
JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke.
Neuroinflammatory Diseases
Kaempferol acts through mitogen-activated protein kinases and protein kinase B/Akt to elicit protection in a model of neuroinflammation in BV2 microglial cells.
Neuroinflammatory Diseases
Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.
Neuroinflammatory Diseases
Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-?B p50 signaling in cultured microglia cells.
Neuroinflammatory Diseases
Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis.
Neuroinflammatory Diseases
LRRK2 Ablation Attenuates ?lpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo.
Neuroinflammatory Diseases
LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?
Neuroinflammatory Diseases
LRRK2 at the Interface Between Peripheral and Central Immune Function in Parkinson's.
Neuroinflammatory Diseases
LRRK2 inhibition attenuates microglial inflammatory responses.
Neuroinflammatory Diseases
LRRK2 modifies ?-syn pathology and spread in mouse models and human neurons.
Neuroinflammatory Diseases
LRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson's Disease.
Neuroinflammatory Diseases
Mammalian STE20-like Kinase 1 Knockdown Attenuates TNF?-Mediated Neurodegenerative Disease by Repressing the JNK Pathway and Mitochondrial Stress.
Neuroinflammatory Diseases
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.
Neuroinflammatory Diseases
Matcha Improves Metabolic Imbalance-Induced Cognitive Dysfunction.
Neuroinflammatory Diseases
Mechanism of Non-receptor Tyrosine Kinase Src Regulating Neuroinflammation Through Phosphatase and Tensin Homology Protein in Microglia.
Neuroinflammatory Diseases
Melatonin Rescue Oxidative Stress-Mediated Neuroinflammation/ Neurodegeneration and Memory Impairment in Scopolamine-Induced Amnesia Mice Model.
Neuroinflammatory Diseases
Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage.
Neuroinflammatory Diseases
Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27 phosphorylation, and cell cycle: role and targeting.
Neuroinflammatory Diseases
Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo.
Neuroinflammatory Diseases
Mutations in LRRK2 impair NF-?B pathway in iPSC-derived neurons.
Neuroinflammatory Diseases
Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies.
Neuroinflammatory Diseases
Novel inhibitors of Rho-kinase mediated neuroinflammatory pathways and their potential application in recovery of injured spinal cord.
Neuroinflammatory Diseases
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology.
Neuroinflammatory Diseases
Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation.
Neuroinflammatory Diseases
Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation.
Neuroinflammatory Diseases
Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.
Neuroinflammatory Diseases
Pharmacotherapy of Alzheimer's Disease: Seeking Clarity in a Time of Uncertainty.
Neuroinflammatory Diseases
Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor ?-mediated neurotoxicity.
Neuroinflammatory Diseases
Platelet-Derived Growth Factor Receptor-? Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice.
Neuroinflammatory Diseases
Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models.
Neuroinflammatory Diseases
Potential involvement of glycogen synthase kinase (GSK)-3? in a rat model of multiple sclerosis: evidenced by lithium treatment.
Neuroinflammatory Diseases
Radiofluorination of oxazole-carboxamides for preclinical PET neuroimaging of GSK-3.
Neuroinflammatory Diseases
Raf kinase inhibitor protein protects microglial cells against 1-methyl-4-phenylpyridinium-induced neuroinflammation in vitro.
Neuroinflammatory Diseases
RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L.
Neuroinflammatory Diseases
Role of glial 14-3-3 gamma protein in autoimmune demyelination.
Neuroinflammatory Diseases
Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy.
Neuroinflammatory Diseases
Roles of Glycogen synthase kinase 3 in Alzheimer's disease.
Neuroinflammatory Diseases
Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors.
Neuroinflammatory Diseases
Single Inflammatory Trigger Leads to Neuroinflammation in LRRK2 Rodent Model without Degeneration of Dopaminergic Neurons.
Neuroinflammatory Diseases
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide.
Neuroinflammatory Diseases
Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management.
Neuroinflammatory Diseases
The correlation between accumulation of amyloid beta with enhanced neuroinflammation and cognitive impairment after intraventricular hemorrhage.
Neuroinflammatory Diseases
The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study.
Neuroinflammatory Diseases
The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling.
Neuroinflammatory Diseases
The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain.
Neuroinflammatory Diseases
The Unlikely Partnership Between LRRK2 and ?-Synuclein in Parkinson's Disease.
Neuroinflammatory Diseases
Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1.
Neurologic Manifestations
Isorhapontigenin alleviates cerebral ischemia/reperfusion injuries in rats and modulated the PI3K/Akt signaling pathway.
Neurologic Manifestations
Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice.
Neurologic Manifestations
[Influence of acupuncture intervention on neurologic deficits, cerebrocortical cell apoptosis and Protein kinase A expression in rats with focal cerebral ischemia].
Neuroma, Acoustic
Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides.
Neuroma, Acoustic
Inhibition of c-Jun N-Terminal Kinase Activity Enhances Vestibular Schwannoma Cell Sensitivity to Gamma Irradiation.
Neuroma, Acoustic
MicroRNA-21 Overexpression Contributes to Vestibular Schwannoma Cell Proliferation and Survival.
Neutropenia
A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient.
Neutropenia
G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis.
Nevus
Activation of c-jun N-terminal kinase is associated with cell proliferation and shorter relapse-free period in superficial spreading malignant melanoma.
Nevus
ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis.
Nevus
Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome.
Nevus
Expression of activated Akt in benign nevi, Spitz nevi and melanomas.
Nevus
Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas).
Nevus
Melanocytic nevi excised during B-Raf proto-oncogene (BRAF) inhibitor therapy: A study of 19 lesions from 10 patients.
Nevus
Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases.
Nevus
Tissue microarray analysis of ezrin, KBA.62, CD166, nestin, and p-Akt in melanoma versus banal and atypical nevi, and nonmelanocytic lesions.
Nevus, Blue
Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.
Nevus, Pigmented
Improving classification of melanocytic nevi: Association of BRAF V600E expression with distinct histomorphologic features.
Nevus, Pigmented
Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi.
Nevus, Pigmented
Melanocytic nevi excised during B-Raf proto-oncogene (BRAF) inhibitor therapy: A study of 19 lesions from 10 patients.
Nevus, Pigmented
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Newcastle Disease
A Raf kinase inhibitor demonstrates antiviral activities both in vitro and in vivo against different genotypes of virulent Newcastle disease virus.
Newcastle Disease
Autophagy in farm animals: current knowledge and future challenges.
Newcastle Disease
Expression of Raf kinase inhibitor protein is downregulated in response to Newcastle disease virus infection to promote viral replication.
Newcastle Disease
Viral strategies for triggering and manipulating mitophagy.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Nijmegen Breakage Syndrome
Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns.
Nijmegen Breakage Syndrome
AsSIRTing the DNA damage response.
Nijmegen Breakage Syndrome
Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays.
Nijmegen Breakage Syndrome
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
Nijmegen Breakage Syndrome
Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance.
Nijmegen Breakage Syndrome
Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells.
Nijmegen Breakage Syndrome
Identification of proteins in the hamster DNA end-binding complex.
Nijmegen Breakage Syndrome
Individual differences in chromosomal aberrations after in vitro irradiation of cells from healthy individuals, cancer and cancer susceptibility syndrome patients.
Nijmegen Breakage Syndrome
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks.
Nijmegen Breakage Syndrome
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Nijmegen Breakage Syndrome
Radiation, DNA damage and cancer.
Nijmegen Breakage Syndrome
Recombinational DNA repair and human disease.
Nijmegen Breakage Syndrome
Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells.
Nijmegen Breakage Syndrome
The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment.
Nijmegen Breakage Syndrome
The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and Induces Apoptosis.
Non-alcoholic Fatty Liver Disease
17?-estradiol ameliorates lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance.
Non-alcoholic Fatty Liver Disease
Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Non-alcoholic Fatty Liver Disease
c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps.
Non-alcoholic Fatty Liver Disease
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice.
Non-alcoholic Fatty Liver Disease
Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.
Non-alcoholic Fatty Liver Disease
Circ_0057558 promotes nonalcoholic fatty liver disease by regulating ROCK1/AMPK signaling through targeting miR-206.
Non-alcoholic Fatty Liver Disease
Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA?treated HepG2 cells.
Non-alcoholic Fatty Liver Disease
Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy.
Non-alcoholic Fatty Liver Disease
Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
Non-alcoholic Fatty Liver Disease
Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.
Non-alcoholic Fatty Liver Disease
Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways.
Non-alcoholic Fatty Liver Disease
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver.
Non-alcoholic Fatty Liver Disease
JNK regulation of hepatic manifestations of the metabolic syndrome.
Non-alcoholic Fatty Liver Disease
JNK1 but not JNK2 promotes the development of steatohepatitis in mice.
Non-alcoholic Fatty Liver Disease
Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Non-alcoholic Fatty Liver Disease
LncRNA NEAT1 promotes hepatic lipid accumulation via regulating miR-146a-5p/ROCK1 in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
LRRK2 Regulates CPT1A to Promote ?-Oxidation in HepG2 Cells.
Non-alcoholic Fatty Liver Disease
Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis.
Non-alcoholic Fatty Liver Disease
Rho kinase/AMPK axis regulates hepatic lipogenesis during overnutrition.
Non-alcoholic Fatty Liver Disease
Roles and mechanisms of NRG1 in modulating the pathogenesis of NAFLD through ErbB3 signaling in hepatocytes (NRG1 modulates NAFLD through ErbB3 signaling).
Non-alcoholic Fatty Liver Disease
Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin.
Non-alcoholic Fatty Liver Disease
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.
Non-alcoholic Fatty Liver Disease
The ASK1 Inhibitor Selonsertib in Patients with Nonalcoholic Steatohepatitis: A Randomized, Phase 2 Trial.
Non-alcoholic Fatty Liver Disease
The ménage à trois of autophagy, lipid droplets and liver disease.
Non-alcoholic Fatty Liver Disease
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Non-alcoholic Fatty Liver Disease
[Activation of Kupffer cell and related signal pathway proteins in the liver of high fat and high fructose diet induced NAFLD mice].
Non-alcoholic Fatty Liver Disease
[Role of JNK signal transduction pathway in nonalcoholic fatty liver disease]
non-specific serine/threonine protein kinase deficiency
14-3-3? and ? regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain.
non-specific serine/threonine protein kinase deficiency
3-phosphoinositide-dependent kinase 1 deficiency perturbs Toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells.
non-specific serine/threonine protein kinase deficiency
Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition.
non-specific serine/threonine protein kinase deficiency
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.
non-specific serine/threonine protein kinase deficiency
Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity.
non-specific serine/threonine protein kinase deficiency
Ataxia telangiectasia mutated deficiency does not result in genetic susceptibility to 50?Hz magnetic fields exposure in mouse embryonic fibroblasts.
non-specific serine/threonine protein kinase deficiency
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.
non-specific serine/threonine protein kinase deficiency
CARD3 deficiency exacerbates diet-induced obesity, hepatosteatosis, and insulin resistance in male mice.
non-specific serine/threonine protein kinase deficiency
CARD3 Deficiency Protects Against Colitis Through Reduced Epithelial Cell Apoptosis.
non-specific serine/threonine protein kinase deficiency
Chromosomal end-to-end fusions in immortalized mouse embryonic fibroblasts deficient in the DNA-dependent protein kinase catalytic subunit.
non-specific serine/threonine protein kinase deficiency
Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy.
non-specific serine/threonine protein kinase deficiency
Conditional Aurora A deficiency differentially affects early mouse embryo patterning.
non-specific serine/threonine protein kinase deficiency
Consequences of DNA-dependent protein kinase catalytic subunit deficiency on recombinant adeno-associated virus genome circularization and heterodimerization in muscle tissue.
non-specific serine/threonine protein kinase deficiency
Deciphering phenotypic variance in different models of DNA-PKcs deficiency.
non-specific serine/threonine protein kinase deficiency
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
non-specific serine/threonine protein kinase deficiency
Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice.
non-specific serine/threonine protein kinase deficiency
Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.
non-specific serine/threonine protein kinase deficiency
Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy.
non-specific serine/threonine protein kinase deficiency
Dissecting the Mechanisms of Doxorubicin and Oxidative Stress-Induced Cytotoxicity: The Involvement of Actin Cytoskeleton and ROCK1.
non-specific serine/threonine protein kinase deficiency
DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts.
non-specific serine/threonine protein kinase deficiency
DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance?
non-specific serine/threonine protein kinase deficiency
DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.
non-specific serine/threonine protein kinase deficiency
DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination.
non-specific serine/threonine protein kinase deficiency
DNA-PKcs deficiency in human: long predicted, finally found.
non-specific serine/threonine protein kinase deficiency
DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation.
non-specific serine/threonine protein kinase deficiency
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
non-specific serine/threonine protein kinase deficiency
DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-?B pathway.
non-specific serine/threonine protein kinase deficiency
DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly.
non-specific serine/threonine protein kinase deficiency
Effect of Ku86 and DNA-PKcs deficiency on non-homologous end-joining and homologous recombination using a transient transfection assay.
non-specific serine/threonine protein kinase deficiency
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
non-specific serine/threonine protein kinase deficiency
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination.
non-specific serine/threonine protein kinase deficiency
Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair.
non-specific serine/threonine protein kinase deficiency
Glycogen Synthase Kinase-3 and phospholipase C-beta signalling: Roles and possible interactions in myelodysplastic syndromes and acute myeloid leukemia.
non-specific serine/threonine protein kinase deficiency
High LET Radiation Amplifies Centrosome Overduplication Through a Pathway of ?-Tubulin Monoubiquitination.
non-specific serine/threonine protein kinase deficiency
HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity.
non-specific serine/threonine protein kinase deficiency
HIPK2 is necessary for type I interferon-mediated antiviral immunity.
non-specific serine/threonine protein kinase deficiency
HIPK2 phosphorylates HDAC3 for NF-?B acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.
non-specific serine/threonine protein kinase deficiency
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.
non-specific serine/threonine protein kinase deficiency
Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia.
non-specific serine/threonine protein kinase deficiency
Inactivation of homeodomain-interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53-dependent E-cadherin expression.
non-specific serine/threonine protein kinase deficiency
Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration.
non-specific serine/threonine protein kinase deficiency
Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs.
non-specific serine/threonine protein kinase deficiency
Kinome siRNA screen identifies SMG-1 as a negative regulator of HIF-1alpha in hypoxia.
non-specific serine/threonine protein kinase deficiency
Lack of spontaneous and radiation-induced chromosome breakage at interstitial telomeric sites in murine scid cells.
non-specific serine/threonine protein kinase deficiency
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
non-specific serine/threonine protein kinase deficiency
Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
non-specific serine/threonine protein kinase deficiency
Leucine-rich repeat kinase 2 regulates mouse dendritic cell migration by ORAI2.
non-specific serine/threonine protein kinase deficiency
Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration.
non-specific serine/threonine protein kinase deficiency
Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype.
non-specific serine/threonine protein kinase deficiency
LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
non-specific serine/threonine protein kinase deficiency
LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.
non-specific serine/threonine protein kinase deficiency
LRRK2 deficiency impacts ceramide metabolism in brain.
non-specific serine/threonine protein kinase deficiency
LRRK2 Deficiency Impairs trans-Golgi to Lysosome Trafficking and Endocytic Cargo Degradation in Human Renal Proximal Tubule Epithelial Cells.
non-specific serine/threonine protein kinase deficiency
LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.
non-specific serine/threonine protein kinase deficiency
LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.
non-specific serine/threonine protein kinase deficiency
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
non-specific serine/threonine protein kinase deficiency
LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production.
non-specific serine/threonine protein kinase deficiency
LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.
non-specific serine/threonine protein kinase deficiency
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.
non-specific serine/threonine protein kinase deficiency
Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice.
non-specific serine/threonine protein kinase deficiency
p53 Inhibits Adeno-Associated Viral Vector Integration.
non-specific serine/threonine protein kinase deficiency
Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts.
non-specific serine/threonine protein kinase deficiency
Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency.
non-specific serine/threonine protein kinase deficiency
Protein kinase A deficiency causes axially localized neural tube defects in mice.
non-specific serine/threonine protein kinase deficiency
Protein kinase D1 deficiency promotes differentiation in epidermal keratinocytes.
non-specific serine/threonine protein kinase deficiency
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.
non-specific serine/threonine protein kinase deficiency
Repair of radiation damage of U2OS osteosarcoma cells is related to DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity.
non-specific serine/threonine protein kinase deficiency
Restoration of T cell-specific V(D)J recombination in DNA-PKcs(-/-) mice by ionizing radiation: The effects on survival, development, and tumorigenesis.
non-specific serine/threonine protein kinase deficiency
ROCK1 Deficiency Enhances Protective Effects of Antioxidants against Apoptosis and Cell Detachment.
non-specific serine/threonine protein kinase deficiency
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
non-specific serine/threonine protein kinase deficiency
ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating the LATS2-JNK signaling pathway.
non-specific serine/threonine protein kinase deficiency
ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice.
non-specific serine/threonine protein kinase deficiency
ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.
non-specific serine/threonine protein kinase deficiency
Role of mammalian Rad54 in telomere length maintenance.
non-specific serine/threonine protein kinase deficiency
SCID dogs: similar transplant potential but distinct intra-uterine growth defects and premature replicative senescence compared with SCID mice.
non-specific serine/threonine protein kinase deficiency
SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency.
non-specific serine/threonine protein kinase deficiency
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
non-specific serine/threonine protein kinase deficiency
Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.
non-specific serine/threonine protein kinase deficiency
Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex.
non-specific serine/threonine protein kinase deficiency
Targeted disruption of ROCK1 causes insulin resistance in vivo.
non-specific serine/threonine protein kinase deficiency
Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence.
non-specific serine/threonine protein kinase deficiency
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.
non-specific serine/threonine protein kinase deficiency
The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair.
non-specific serine/threonine protein kinase deficiency
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.
non-specific serine/threonine protein kinase deficiency
The familial Parkinsonism gene LRRK2 regulates neurite process morphology.
non-specific serine/threonine protein kinase deficiency
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
non-specific serine/threonine protein kinase deficiency
The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas.
non-specific serine/threonine protein kinase deficiency
The Mechanisms of PD-L1 Regulation in Non-Small-Cell Lung Cancer (NSCLC): Which Are the Involved Players?
non-specific serine/threonine protein kinase deficiency
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.
non-specific serine/threonine protein kinase deficiency
The profiles of gamma-H2AX along with ATM/DNA-PKcs activation in the lymphocytes and granulocytes of rat and human blood exposed to gamma rays.
non-specific serine/threonine protein kinase deficiency
The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.
non-specific serine/threonine protein kinase deficiency
The regenerating family member 3 ? instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.
non-specific serine/threonine protein kinase deficiency
The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition.
non-specific serine/threonine protein kinase deficiency
Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma.
non-specific serine/threonine protein kinase deficiency
Update on DNA-Double Strand Break Repair Defects in Combined Primary Immunodeficiency.
non-specific serine/threonine protein kinase deficiency
Vanillin derivative VND3207 activates DNA-PKcs conferring protection against radiation-induced intestinal epithelial cells injury in vitro and in vivo.
non-specific serine/threonine protein kinase deficiency
Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population.
non-specific serine/threonine protein kinase deficiency
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Noonan Syndrome
Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription.
Noonan Syndrome
Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder within the RASopathy Clinical Spectrum.
Noonan Syndrome
Establishment of an induced pluripotent stem cell line from a Noonan syndrome patient with the heterozygote mutation p.S257L (c.770C > T) in RAF1 gene.
Noonan Syndrome
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
Noonan Syndrome
Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Noonan Syndrome
miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1.
Noonan Syndrome
PHENOTYPIC CONSEQUENCES AND THE MALIGNANCY RISK IN FAMILIAL NOONAN SYNDROME DUE TO A RARE P.S427G RAF1 MUTATION.
Noonan Syndrome
[New findings in Noonan syndrome and Leopard syndrome: activating mutations in RAF-1 and SOS-1]
Obesity
17?-estradiol ameliorates lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance.
Obesity
?-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells.
Obesity
A nontargeted proteomic approach to the study of visceral and subcutaneous adipose tissue in human obesity.
Obesity
A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans.
Obesity
Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.
Obesity
Adipose-Specific Inactivation of JNK Alleviates Atherosclerosis in ApoE-deficient Mice.
Obesity
Ameliorative effect of low-dose spironolactone on obesity and insulin resistance is through replenishment of estrogen in ovariectomized rats.
Obesity
Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology.
Obesity
Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes.
Obesity
Anti-obesity effects of 3-hydroxychromone derivative, a novel small-molecule inhibitor of glycogen synthase kinase-3.
Obesity
Anti?obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes
Obesity
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.
Obesity
C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
Obesity
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.
Obesity
Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?
Obesity
CARD3 deficiency exacerbates diet-induced obesity, hepatosteatosis, and insulin resistance in male mice.
Obesity
Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.
Obesity
Crystal structures of the S6K1 kinase domain in complexes with inhibitors.
Obesity
DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity.
Obesity
Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3?) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity.
Obesity
Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.
Obesity
Differentially regulated protein kinase A (PKA) activity in adipose tissue and liver is associated with resistance to diet-induced obesity and glucose intolerance in mice that lack PKA regulatory subunit type II?.
Obesity
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Obesity
Double-Stranded RNA-Activated Protein Kinase Is a Key Modulator of Insulin Sensitivity in Physiological Conditions and in Obesity in Mice.
Obesity
Dysfunction of human subcutaneous FAT arterioles in obesity associated or not with Type 2 diabetes.
Obesity
Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetes.
Obesity
Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
Obesity
Effects of Physical Exercise on the P38MAPK/REDD1/14-3-3 Pathways in the Myocardium of Diet-Induced Obesity Rats.
Obesity
Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes.
Obesity
Epigenome-Wide Study Identified Methylation Sites Associated with the Risk of Obesity.
Obesity
Explore the Protective Role of Obesity in the Progression of Myocardial Infarction.
Obesity
Free fatty acid-induced H2O2 activates TRPM2 to aggravate endothelial insulin resistance via Ca2+-dependent PERK/ATF4/TRB3 cascade in obese mice.
Obesity
Glycogen synthase kinase 3 in Wnt signaling pathway and cancer.
Obesity
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism.
Obesity
GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1.
Obesity
Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
Obesity
High fat diet induced obesity alters ovarian phosphatidylinositol-3 kinase signaling gene expression.
Obesity
High glucose impairs insulin signaling via activation of PKR pathway in L6 muscle cells.
Obesity
Human Protein Kinases and Obesity.
Obesity
Identification of Aurora Kinase A as a Biomarker for Prognosis in Obesity Patients with Early Breast Cancer.
Obesity
Identification of Hipk2 as an essential regulator of white fat development.
Obesity
Identification of lead small molecule inhibitors of glycogen synthase kinase-3 beta using a fragment-linking strategy.
Obesity
Imoxin attenuates high fructose-induced oxidative stress and apoptosis in renal epithelial cells via downregulation of protein kinase R pathway.
Obesity
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.
Obesity
Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit.
Obesity
Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.
Obesity
JNK signaling pathway in metabolic disorders: An emerging therapeutic target.
Obesity
Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.
Obesity
Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity.
Obesity
Low salt intake modulates insulin signaling, JNK activity and IRS-1ser307 phosphorylation in rat tissues.
Obesity
LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes.
Obesity
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Obesity
Mapping and association studies of diabetes related genes in the pig.
Obesity
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer.
Obesity
Mutation of the RIIbeta subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue.
Obesity
Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice.
Obesity
Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance.
Obesity
Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.
Obesity
Novel roles for JNK1 in metabolism.
Obesity
Obesity of G2e3 Knockout Mice Suggests That Obesity-Associated Variants Near Human G2E3 Decrease G2E3 Activity.
Obesity
Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase.
Obesity
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Obesity
Oral hormonal therapy with ethinylestradiol/levonorgestrel improves insulin resistance, obesity and glycogen synthase kinase-3 independent of circulating mineralocorticoid in estrogen-deficient rats.
Obesity
Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation.
Obesity
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Obesity
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.
Obesity
PKA-RIIB Deficiency Induces Brown Fatlike Adipocytes in Inguinal WAT and Promotes Energy Expenditure in Male FVB/NJ Mice.
Obesity
PLS and shape-based similarity analysis of maleimides - GSK-3 inhibitors.
Obesity
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Obesity
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
Obesity
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice.
Obesity
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice.
Obesity
Protein kinase A regulatory subunits in human adipose tissue: decreased R2B expression and activity in adipocytes from obese subjects.
Obesity
Protein kinase C? activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation.
Obesity
Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.
Obesity
Research Progress of 70 kDa Ribosomal Protein S6 Kinase (P70S6K) Inhibitors as Effective Therapeutic Tools for Obesity, Type II Diabetes and Cancer.
Obesity
Rho kinase/AMPK axis regulates hepatic lipogenesis during overnutrition.
Obesity
Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling.
Obesity
ROCK1 in AgRP Neurons Regulates Energy Expenditure and Locomotor Activity in Male Mice.
Obesity
ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance.
Obesity
ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity.
Obesity
Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes.
Obesity
Role of CaMKII in the regulation of fatty acids and lipid metabolism.
Obesity
Role of exercise-induced calmodulin protein kinase (CAMK)II activation in the regulation of omega-6 fatty acids and lipid metabolism genes in rat skeletal muscle.
Obesity
Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.
Obesity
Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply.
Obesity
Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice.
Obesity
Structural basis for compound C inhibition of the human AMP-activated protein kinase ?2 subunit kinase domain.
Obesity
Targeted disruption of ROCK1 causes insulin resistance in vivo.
Obesity
Targeting of the circadian clock via CK1?/? to improve glucose homeostasis in obesity.
Obesity
The 14-3-3 proteins in regulation of cellular metabolism.
Obesity
The consequences of long-term glycogen synthase kinase-3 inhibition on normal and insulin resistant rat hearts.
Obesity
The effect of metformin on biomarkers and survivals for breast cancer- a systematic review and meta-analysis of randomized clinical trials.
Obesity
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Obesity
The expression of CCN2, IQSEC, RSPO1, DNAJC15, RIPK2, IL13RA2, IRS1, and IRS2 genes in blood of obese boys with insulin resistance.
Obesity
The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
Obesity
The role for endoplasmic reticulum stress in diabetes mellitus.
Obesity
The role of uncoupling protein 1 in the metabolism and adiposity of RII beta-protein kinase A-deficient mice.
Obesity
Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice.
Obesity
Tissue-Specific Approaches Reveal Diverse Metabolic Functions of Rho-Kinase 1.
Obesity
Trangenic and knockout rodents: novel insights into mechanisms of body weight regulation.
Obesity
Zinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-?/p53 signaling pathways.
Obesity, Abdominal
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.
Obesity, Morbid
Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling.
Ocular Hypertension
Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma.
Oligodendroglioma
Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.
Oligodendroglioma
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Oligodendroglioma
Vasculogenic Mimicry Formation Predicts Tumor Progression in Oligodendroglioma.
Oligohydramnios
[Compound danshen injection regulated the expression of AQP3 in the human amnion epithelium cells through JNK signal pathway].
Oligospermia
Mutation screening and association study of the TSSK4 Gene in Chinese infertile men with impaired spermatogenesis.
Oligospermia
Searching for candidate genes for male infertility.
Oligospermia
Some Single Nucleotide Polymorphisms of the TSSK2 Gene May Be Associated with Human Spermatogenesis Impairment.
Optic Atrophy
Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts.
Optic Atrophy
Iraqi-Jewish kindreds with optic atrophy plus (3-methylglutaconic aciduria type 3) demonstrate linkage disequilibrium with the CTG repeat in the 3' untranslated region of the myotonic dystrophy protein kinase gene.
Optic Atrophy, Autosomal Dominant
OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells.
Optic Atrophy, Autosomal Dominant
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis.
Optic Atrophy, Autosomal Dominant
The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy.
Optic Nerve Injuries
Activation of cell survival signals in the goldfish retinal ganglion cells after optic nerve injury.
Optic Nerve Injuries
Akt is activated via insulin/IGF-1 receptor in rat retina with episcleral vein cauterization.
Optic Neuritis
Tau protein: a possible prognostic factor in optic neuritis and multiple sclerosis.
Osteoarthritis
14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis.
Osteoarthritis
A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.
Osteoarthritis
Activation of innate immunity by 14-3-3 ?, a new potential alarmin in osteoarthritis.
Osteoarthritis
Altered Wnt and NF-?B Signaling in Facet Joint Osteoarthritis: Insights from RNA Deep Sequencing.
Osteoarthritis
c-Jun N-terminal kinase - c-Jun pathway transactivates Bim to promote osteoarthritis.
Osteoarthritis
Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis.
Osteoarthritis
Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway.
Osteoarthritis
Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR?4428/FUT2 axis.
Osteoarthritis
Comment on: Deletion of c-Jun N-terminal Kinase Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice.
Osteoarthritis
Comparison of Serum Levels of 14-3-3 ETA Proteins between Rheumatoid Arthritis, Osteoarthritis and Normal Controls.
Osteoarthritis
Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27.
Osteoarthritis
Effects of sodium selenite on c-Jun N-terminal kinase signalling pathway induced by oxidative stress in human chondrocytes and c-Jun N-terminal kinase expression in patients with Kashin-Beck disease, an endemic osteoarthritis.
Osteoarthritis
Epigallocatechin-3-gallate selectively inhibits interleukin-1beta-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes.
Osteoarthritis
Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis.
Osteoarthritis
Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.
Osteoarthritis
Increased levels of the 14-3-3 ? and ? proteins in the synovial fluid of dogs with unilateral cranial cruciate ligament rupture.
Osteoarthritis
Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients.
Osteoarthritis
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology.
Osteoarthritis
Nanosome-Mediated Delivery Of Protein Kinase D Inhibitor Protects Chondrocytes From Interleukin-1?-Induced Stress And Apoptotic Death.
Osteoarthritis
Protein kinase B and extracellular signal-regulated kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes.
Osteoarthritis
SP600125, a JNK-Specific Inhibitor, Regulates in vitro Auricular Cartilage Regeneration by Promoting Cell Proliferation and Inhibiting Extracellular Matrix Metabolism.
Osteoarthritis
The inhibition of PLC?1 protects chondrocytes against osteoarthritis, implicating its binding to Akt.
Osteoarthritis
TNF?? increases inflammatory factor expression in synovial fibroblasts through the toll?like receptor?3?mediated ERK/AKT signaling pathway in a mouse model of rheumatoid arthritis.
Osteoarthritis, Knee
Activation of the extracellular-signal-regulated kinase (ERK)/c-Jun N-terminal kinase (JNK) signal pathway and osteogenic factors in subchondral bone of patients with knee osteoarthritis.
Osteoarthritis, Knee
Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes.
Osteoarthritis, Knee
Upregulation of urokinase-type plasminogen activator and inhibitor and gelatinase expression via 3 mitogen-activated protein kinases and PI3K pathways during the early development of osteoarthritis.
Osteochondritis Dissecans
Autophagy in farm animals: current knowledge and future challenges.
Osteochondroma
Bizarre parosteal osteochondromatous proliferation in the lingual area of the mandibular body versus osteochondroma at the mandibular condyle.
Osteolysis
Deficiency of PDK1 in osteoclasts delays fracture healing and repair.
Osteolysis
The USP14-NLRC5 pathway inhibits titanium particle-induced osteolysis in mice by suppressing NF-?B and PI3K/AKT activities.
Osteomyelitis
The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.
Osteopetrosis
Targeted disruption of leucine-rich repeat kinase 1 but not Leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.
Osteoporosis
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Osteoporosis
Chitosan/siCkip-1 biofunctionalized titanium implant for improved osseointegration in the osteoporotic condition.
Osteoporosis
CK2.3, a Mimetic Peptide of the BMP Type I Receptor, Increases Activity in Osteoblasts over BMP2.
Osteoporosis
CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
Osteoporosis
Discovery of potent and bioavailable GSK-3beta inhibitors.
Osteoporosis
Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug.
Osteoporosis
Mongolian Medicine echinops prevented postmenopausal osteoporosis and induced ER/AKT/ERK pathway in BMSCs.
Osteoporosis
Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis.
Osteoporosis
The identification and structural analysis of potential 14-3-3 interaction sites on the bone regulator protein Schnurri-3.
Osteoporosis
The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats.
Osteoporosis
Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/?-Catenin/ATF4 Signaling Pathways.
Osteoporosis, Postmenopausal
Effect of lncRNA AK023948 on rats with postmenopausal osteoporosis via PI3K/AKT signaling pathway.
Osteosarcoma
6-Hydroxythiobinupharidine Inhibits Migration of LM8 Osteosarcoma Cells by Decreasing Expression of LIM Domain Kinase 1.
Osteosarcoma
A correlation analysis between tumor imaging changes and p-AKT and HSP70 expression in tumor cells after osteosarcoma chemotherapy.
Osteosarcoma
Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway.
Osteosarcoma
alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression.
Osteosarcoma
An EGFR and AKT Signaling Pathway was Identified with Mediation Model in Osteosarcomas Clinical Study.
Osteosarcoma
Calcitonin-induced NF-?B activation up-regulates fibronectin expression in MG63 osteosarcoma cells.
Osteosarcoma
CCT128930 induces G1-phase arrest and apoptosis and synergistically enhances the anticancer efficiency of VS5584 in human osteosarcoma cells.
Osteosarcoma
CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity.
Osteosarcoma
CIP2A is overexpressed in osteosarcoma and regulates cell proliferation and invasion.
Osteosarcoma
Combined microRNA-340 and ROCK1 mRNA profiling predicts tumor progression and prognosis in pediatric osteosarcoma.
Osteosarcoma
Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.
Osteosarcoma
Downregulation of DNA-PKcs suppresses P-gp expression via inhibition of the Akt/NF-?B pathway in CD133-positive osteosarcoma MG-63 cells.
Osteosarcoma
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Osteosarcoma
EPEL promotes the migration and invasion of osteosarcoma cells by upregulating ROCK1.
Osteosarcoma
Expression of the CT/CGRP gene and its regulation by dibutyryl cyclic adenosine monophosphate in human osteoblastic cells.
Osteosarcoma
Expression of the nucleoside triphosphate pyrophosphohydrolase PC-1 is induced by basic fibroblast growth factor (bFGF) and modulated by activation of the protein kinase A and C pathways in osteoblast-like osteosarcoma cells.
Osteosarcoma
Four genes predict the survival of osteosarcoma patients based on TARGET database.
Osteosarcoma
FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness.
Osteosarcoma
Gallic Acid Induces the Apoptosis of Human Osteosarcoma Cells In Vitro and In Vivo via the Regulation of Mitogen-Activated Protein Kinase Pathways.
Osteosarcoma
Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways.
Osteosarcoma
Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients.
Osteosarcoma
Gefitinib Inhibits Invasion and Metastasis of Osteosarcoma via Inhibition of Macrophage Receptor Interacting Serine-Threonine Kinase 2.
Osteosarcoma
Gelsolin promotes cell growth and invasion through the upregulation of p-AKT and p-P38 pathway in osteosarcoma.
Osteosarcoma
GSK-3 inhibitor inhibits cell proliferation and induces apoptosis in human osteosarcoma cells.
Osteosarcoma
How wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow.
Osteosarcoma
Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells.
Osteosarcoma
Identification of two potential glycogen synthase kinase 3? inhibitors for the treatment of osteosarcoma.
Osteosarcoma
Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor.
Osteosarcoma
Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells.
Osteosarcoma
Interleukin-24 inhibits osteosarcoma cell migration and invasion via the JNK/c-Jun signaling pathways.
Osteosarcoma
LncRNA LINC00628 overexpression inhibits the growth and invasion through regulating PI3K/Akt signaling pathway in osteosarcoma.
Osteosarcoma
lncRNA SNHG1 negatively regulates miRNA?101?3p to enhance the expression of ROCK1 and promote cell proliferation, migration and invasion in osteosarcoma.
Osteosarcoma
LncRNA TDRG1 Promotes Proliferation, Invasion and Epithelial-Mesenchymal Transformation of Osteosarcoma Through PI3K/AKT Signal Pathway.
Osteosarcoma
Long non-coding RNA CCHE1 participates in postoperative distant recurrence but not local recurrence of osteosarcoma possibly by interacting with ROCK1.
Osteosarcoma
Long non-coding RNA HOXA11-AS functions as a competing endogenous RNA to regulate ROCK1 expression by sponging miR-124-3p in osteosarcoma.
Osteosarcoma
Long non-coding RNA MALAT1 for promoting metastasis and proliferation by acting as a ceRNA of miR-144-3p in osteosarcoma cells.
Osteosarcoma
Long non-coding RNA SNHG5 sponges miR-26a to promote the tumorigenesis of osteosarcoma by targeting ROCK1.
Osteosarcoma
Long non-coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR-335-5p in osteosarcoma cells.
Osteosarcoma
Long Noncoding RNA HAGLROS Promotes Cell Invasion and Metastasis by Sponging miR-152 and Upregulating ROCK1 Expression in Osteosarcoma.
Osteosarcoma
LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity.
Osteosarcoma
Mechanism of miR-122-5p regulating the activation of PI3K-Akt-mTOR signaling pathway on the cell proliferation and apoptosis of osteosarcoma cells through targeting TP53 gene.
Osteosarcoma
Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway.
Osteosarcoma
MicroRNA-101 inhibits proliferation, migration and invasion in osteosarcoma cells by targeting ROCK1.
Osteosarcoma
MicroRNA-129-5p suppresses cell proliferation, migration and invasion via targeting ROCK1 in osteosarcoma.
Osteosarcoma
MicroRNA-141 and microRNA-146b-5p inhibit the prometastatic mesenchymal characteristics through the RNA-binding protein AUF1 targeting the transcription factor ZEB1 and the protein kinase AKT.
Osteosarcoma
MicroRNA-144 acts as a tumor suppressor by targeting Rho-associated coiled-coil containing protein kinase 1 in osteosarcoma cells.
Osteosarcoma
MicroRNA-144 suppresses osteosarcoma growth and metastasis by targeting ROCK1 and ROCK2.
Osteosarcoma
microRNA-145 inhibits osteosarcoma cell proliferation and invasion by targeting ROCK1.
Osteosarcoma
MicroRNA-198 inhibited tumorous behaviors of human osteosarcoma through directly targeting ROCK1.
Osteosarcoma
MicroRNA-206 upregulation relieves circTCF25-induced osteosarcoma cell proliferation and migration.
Osteosarcoma
MicroRNA-335 and its target Rock1 synergistically influence tumor progression and prognosis in osteosarcoma.
Osteosarcoma
MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1.
Osteosarcoma
MicroRNA181c inhibits prostate cancer cell growth and invasion by targeting multiple ERK signaling pathway components.
Osteosarcoma
MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma.
Osteosarcoma
miR-139 inhibits osteosarcoma cell proliferation and invasion by targeting ROCK1.
Osteosarcoma
MiR-139 prompts the development of osteosarcomas mainly through targeting ROCK1.
Osteosarcoma
MiR-144 Inhibits Tumor Growth and Metastasis in Osteosarcoma via dual-suppressing RhoA/ROCK1 Signaling Pathway.
Osteosarcoma
miR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1.
Osteosarcoma
miR-150 is downregulated in osteosarcoma and suppresses cell proliferation, migration and invasion by targeting ROCK1.
Osteosarcoma
miR-202-5p inhibits the migration and invasion of osteosarcoma cells by targeting ROCK1.
Osteosarcoma
miR-214-5p Targets ROCK1 and Suppresses Proliferation and Invasion of Human Osteosarcoma Cells.
Osteosarcoma
miR-335 suppresses migration and invasion by targeting ROCK1 in osteosarcoma cells.
Osteosarcoma
NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation.
Osteosarcoma
NOV inhibits proliferation while promoting apoptosis and migration in osteosarcoma cell lines through p38/MAPK and JNK/MAPK pathways.
Osteosarcoma
Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy.
Osteosarcoma
Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.
Osteosarcoma
Oncogenic roles of serine-threonine kinase receptor-associated protein (STRAP) in osteosarcoma.
Osteosarcoma
Overexpression of HIPK2 removes the transrepression of proapoptotic genes mediated by the CtBP1-p300-FOXO3a complex and increases the chemosensitivity in osteosarcoma cells.
Osteosarcoma
Phosphorylation of IRS4 by CK1?2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway.
Osteosarcoma
Pictilisib Enhances the Antitumor Effect of Doxorubicin and Prevents Tumor-Mediated Bone Destruction by Blockade of PI3K/AKT Pathway.
Osteosarcoma
Platelet-derived growth factor-stimulated c-myc RNA accumulation in MG-63 human osteosarcoma cells is independent of both protein kinase A and protein kinase C.
Osteosarcoma
pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase.
Osteosarcoma
Protein Kinase B and Extracellular Signal-Regulated Kinase Inactivation is Associated with Regorafenib-Induced Inhibition of Osteosarcoma Progression In Vitro and In Vivo.
Osteosarcoma
PTHrP, its receptor, and protein kinase A activation in osteosarcoma.
Osteosarcoma
RANKL blockade prevents and treats aggressive osteosarcomas.
Osteosarcoma
Ras activation mediates WISP-1-induced increases in cell motility and matrix metalloproteinase expression in human osteosarcoma.
Osteosarcoma
Repair of radiation damage of U2OS osteosarcoma cells is related to DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity.
Osteosarcoma
Resistin enhances angiogenesis in osteosarcoma via the MAPK signaling pathway.
Osteosarcoma
RNF38 inhibits osteosarcoma cell proliferation by binding to CRY1.
Osteosarcoma
ROCK1 as a potential therapeutic target in osteosarcoma.
Osteosarcoma
ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.
Osteosarcoma
Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
Osteosarcoma
Short Hairpin RNA (shRNA) Ether à go-go 1 (Eag1) Inhibition of Human Osteosarcoma Angiogenesis via VEGF/PI3K/AKT Signaling.
Osteosarcoma
Silencing of RIPK4 inhibits epithelial?mesenchymal transition by inactivating the Wnt/??catenin signaling pathway in osteosarcoma.
Osteosarcoma
Targeting DNA-PKcs increased anticancer drug sensitivity by suppressing DNA damage repair in osteosarcoma cell line MG63.
Osteosarcoma
Targeting the FOXM1-regulated long noncoding RNA TUG1 in osteosarcoma.
Osteosarcoma
TGM2 knockdown reverses cisplatin chemoresistance in osteosarcoma.
Osteosarcoma
The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells.
Osteosarcoma
The Effects of Interleukin-33 (IL-33) on Osteosarcoma Cell Viability, Apoptosis, and Epithelial-Mesenchymal Transition are Mediated Through the PI3K/AKT Pathway.
Osteosarcoma
The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis.
Osteosarcoma
Transforming growth factor-beta type-II receptor signalling: intrinsic/associated casein kinase activity, receptor interactions and functional effects of blocking antibodies.
Osteosarcoma
Vasohibin 1 inhibits Adriamycin resistance in osteosarcoma cells via the protein kinase B signaling pathway.
Osteosarcoma
VEGF silencing inhibits human osteosarcoma angiogenesis and promotes cell apoptosis via PI3K/AKT signaling pathway.
Osteosarcoma
VEGF Silencing Inhibits Human Osteosarcoma Angiogenesis and Promotes Cell Apoptosis via PI3K/AKT Signaling Pathway.
Osteosclerosis
LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.
Otitis Media
C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media.
Ototoxicity
Activation of ?-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells.
Ototoxicity
Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity.
Ototoxicity
Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity.
Ototoxicity
Salicylate-Induced Ototoxicity of Spiral Ganglion Neurons: Ca2+/CaMKII-Mediated Interaction Between NMDA Receptor and GABAA Receptor.
Ototoxicity
Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells.
Ototoxicity
STK33 alleviates gentamicin-induced ototoxicity in cochlear hair cells and House Ear Institute-Organ of Corti 1 cells.
Ototoxicity
Topical administration of oleandrin could protect against gentamicin ototoxicity via inhibition of activator protein-1 and c-Jun N-terminal kinase.
Ototoxicity
Vestibular damage in chronic ototoxicity: A mini-review.
Ovarian Diseases
[Effects of phosphatidylinositol-3 kinase/protein kinase b/bone morphogenetic protein-15 pathway on the follicular development in the mammalian ovary].
Ovarian Neoplasms
14-3-3 ? expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.
Ovarian Neoplasms
A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis.
Ovarian Neoplasms
Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer.
Ovarian Neoplasms
Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells.
Ovarian Neoplasms
Androgen Plays a Carcinogenic Role in EOC via the PI3K/AKT Signaling Pathway in an AR-Dependent Manner.
Ovarian Neoplasms
Antisense oligonucleotide targeting of Raf-1: importance of raf-1 mRNA expression levels and raf-1-dependent signaling in determining growth response in ovarian cancer.
Ovarian Neoplasms
Apoptosis, growth arrest and suppression of invasiveness by CRE-decoy oligonucleotide in ovarian cancer cells: protein kinase A downregulation and cytoplasmic export of CRE-binding proteins.
Ovarian Neoplasms
Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase Inhibition Is Synthetically Lethal in XRCC1 Deficient Ovarian Cancer Cells.
Ovarian Neoplasms
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
Ovarian Neoplasms
ATM-dependent CHK2 activation induced by anticancer agent, irofulven.
Ovarian Neoplasms
Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor.
Ovarian Neoplasms
Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells.
Ovarian Neoplasms
Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer.
Ovarian Neoplasms
Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3.
Ovarian Neoplasms
Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells.
Ovarian Neoplasms
beta-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase.
Ovarian Neoplasms
BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition.
Ovarian Neoplasms
BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers.
Ovarian Neoplasms
Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells.
Ovarian Neoplasms
Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells.
Ovarian Neoplasms
Caveolin-1 mediates chemoresistance in cisplatin-resistant ovarian cancer cells by targeting apoptosis through the Notch-1/Akt/NF-?B pathway.
Ovarian Neoplasms
Clinicopathological and biological significance of aberrant activation of glycogen synthase kinase-3 in ovarian cancer.
Ovarian Neoplasms
Comparison of strategies targeting Raf-1 mRNA in ovarian cancer.
Ovarian Neoplasms
Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells.
Ovarian Neoplasms
Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation.
Ovarian Neoplasms
Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
Ovarian Neoplasms
Depleting Mirk Kinase Increases Cisplatin Toxicity in Ovarian Cancer Cells.
Ovarian Neoplasms
Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells.
Ovarian Neoplasms
Downregulation of TRIM27 expression inhibits the proliferation of ovarian cancer cells in vitro and in vivo.
Ovarian Neoplasms
Dual targeting of GSK3B and HDACs reduces tumor growth and improves survival in an ovarian cancer mouse model.
Ovarian Neoplasms
EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer.
Ovarian Neoplasms
Effect of KN-62, Ca2+/calmodulin-dependent protein kinase II inhibitor, on adriamycin resistance of human ovarian cancer cells.
Ovarian Neoplasms
Emerging serine-threonine kinase inhibitors for treating ovarian cancer.
Ovarian Neoplasms
Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway.
Ovarian Neoplasms
Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib Via Regulation of Rad-51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells.
Ovarian Neoplasms
Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer.
Ovarian Neoplasms
Estrogen regulation of STYK1 expression in estrogen receptor-alpha negative ovarian cancer cell lines.
Ovarian Neoplasms
Exploiting p70 S6 kinase as a target for ovarian cancer.
Ovarian Neoplasms
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
Ovarian Neoplasms
Extracellular signal-regulated protein kinase, but not c-Jun N-terminal kinase, is activated by type II gonadotropin-releasing hormone involved in the inhibition of ovarian cancer cell proliferation.
Ovarian Neoplasms
Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome.
Ovarian Neoplasms
FSH receptor binding inhibitor impacts K-Ras and c-Myc of ovarian cancer and signal pathway.
Ovarian Neoplasms
Genetic Perturbation of Pyruvate Dehydrogenase Kinase 1 Modulates Growth, Angiogenesis and Metabolic Pathways in Ovarian Cancer Xenografts.
Ovarian Neoplasms
Genetic testing by cancer site: stomach.
Ovarian Neoplasms
Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer
Ovarian Neoplasms
Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in Paclitaxel-Resistant Ovarian Cancer Cells.
Ovarian Neoplasms
Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.
Ovarian Neoplasms
Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as new lead to Treat Breast and Ovarian Cancer.
Ovarian Neoplasms
Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells.
Ovarian Neoplasms
GSK-3beta as a driving force in ovarian cancer.
Ovarian Neoplasms
High frequency of pathogenic non-founder germline mutations in BRCA1 and BRCA2 in families with breast and ovarian cancer in a founder population.
Ovarian Neoplasms
High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy.
Ovarian Neoplasms
Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer.
Ovarian Neoplasms
Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer.
Ovarian Neoplasms
Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel.
Ovarian Neoplasms
Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells.
Ovarian Neoplasms
Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid.
Ovarian Neoplasms
Investigating the clinical potential for 14-3-3 zeta protein to serve as a biomarker for epithelioid.
Ovarian Neoplasms
Investigational agents in development for the treatment of ovarian cancer.
Ovarian Neoplasms
Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B.
Ovarian Neoplasms
Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway.
Ovarian Neoplasms
LC-MS/MS Analysis of Ovarian Cancer Metastasis-Related Proteins Using a Nude Mouse Model: 14-3-3 Zeta as a Candidate Biomarker.
Ovarian Neoplasms
Long Noncoding RNA LINC01133 Confers Tumor-Suppressive Functions in Ovarian Cancer by Regulating Leucine-Rich Repeat Kinase 2 as an miR-205 Sponge.
Ovarian Neoplasms
LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair.
Ovarian Neoplasms
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway.
Ovarian Neoplasms
MEK1-independent activation of MAPK and MEK1-dependent activation of p70 S6 kinase by stem cell factor (SCF) in ovarian cancer cells.
Ovarian Neoplasms
MicroRNA-139-5p Inhibit Cell Proliferation and Invasion by Targeting RHO-Associated Coiled-Coil Containing Protein Kinase 2 in Ovarian Cancer.
Ovarian Neoplasms
Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells.
Ovarian Neoplasms
miR-21 regulates the proliferation and apoptosis of ovarian cancer cells through PTEN/PI3K/AKT.
Ovarian Neoplasms
MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells.
Ovarian Neoplasms
Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers.
Ovarian Neoplasms
Nek6 and Hif-1? cooperate with the cytoskeletal gateway of drug resistance to drive outcome in serous ovarian cancer.
Ovarian Neoplasms
New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.
Ovarian Neoplasms
NUCKS nuclear elevated expression indicates progression and prognosis of ovarian cancer.
Ovarian Neoplasms
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Ovarian Neoplasms
Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells.
Ovarian Neoplasms
p21-Activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients.
Ovarian Neoplasms
p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/b1 integrin signaling activation.
Ovarian Neoplasms
p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells.
Ovarian Neoplasms
p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells.
Ovarian Neoplasms
PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness.
Ovarian Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Ovarian Neoplasms
PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via ?5?1 integrin and JNK/IL-8 signaling.
Ovarian Neoplasms
Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
Ovarian Neoplasms
Phosphorylation of glycogen synthase kinase-3 beta at serine 9 confers cisplatin resistance in ovarian cancer cells.
Ovarian Neoplasms
Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT.
Ovarian Neoplasms
Prevalence of deleterious mutations among patients with breast cancer referred for multigene panel testing in a Romanian population.
Ovarian Neoplasms
Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy.
Ovarian Neoplasms
Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study.
Ovarian Neoplasms
Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion.
Ovarian Neoplasms
Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway.
Ovarian Neoplasms
Pyruvate dehydrogenase kinase 1 contributes to cisplatin resistance of ovarian cancer through EGFR activation.
Ovarian Neoplasms
Quantitative proteomic analysis of mitochondria from human ovarian cancer cells and their paclitaxel-resistant sublines.
Ovarian Neoplasms
Raf-1 is the predominant Raf isoform that mediates growth factor-stimulated growth in ovarian cancer cells.
Ovarian Neoplasms
Raf-1 kinase activity predicts for paclitaxel resistance in TP53mut, but not TP53wt human ovarian cancer cells.
Ovarian Neoplasms
REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer.
Ovarian Neoplasms
Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells.
Ovarian Neoplasms
Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian cancer cell line by wild-type PTEN gene.
Ovarian Neoplasms
ROCK cooperated with ET-1 to induce epithelial to mesenchymal transition through SLUG in human ovarian cancer cells.
Ovarian Neoplasms
Role of A-Kinase anchor protein (AKAP4) in growth and survival of ovarian cancer cells.
Ovarian Neoplasms
Role of PELP1/MNAR signaling in ovarian tumorigenesis.
Ovarian Neoplasms
Role of Wnt/?-catenin, Wnt/c-Jun N-terminal kinase and Wnt/Ca(2+) pathways in cisplatin-induced chemoresistance in ovarian cancer.
Ovarian Neoplasms
Roles of Cx43 and AKAP95 in ovarian cancer tissues in G1/S phase.
Ovarian Neoplasms
ShenLingLan Influences the Attachment and Migration of Ovarian Cancer Cells Potentially through the GSK3 Pathway.
Ovarian Neoplasms
SMAD3 inducing the transcription of ?STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.
Ovarian Neoplasms
ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor.
Ovarian Neoplasms
Systematic CpG Islands Methylation Profiling of Genes in the Wnt Pathway in Epithelial Ovarian Cancer Identifies Biomarkers of Progression-Free Survival.
Ovarian Neoplasms
Systematic module approach identifies altered genes and pathways in four types of ovarian cancer.
Ovarian Neoplasms
Tanshinone IIA induces apoptosis of ovarian cancer cells in vitro and in vivo through attenuation of PI3K/AKT/JNK signaling pathways.
Ovarian Neoplasms
TAp73-Mediated the Activation of C-Jun N-Terminal Kinase Enhances Cellular Chemosensitivity to Cisplatin in Ovarian Cancer Cells.
Ovarian Neoplasms
Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes.
Ovarian Neoplasms
Targeting Aurora A Kinase (AAK) in Platinum-Resistant High Grade Serous Ovarian Cancer.
Ovarian Neoplasms
The aberrant upstream pathway regulations of CDK1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells.
Ovarian Neoplasms
The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition.
Ovarian Neoplasms
The role of glycogen synthase kinase 3 (GSK3) in cancer with emphasis on ovarian cancer development and progression: A comprehensive review.
Ovarian Neoplasms
Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer.
Ovarian Neoplasms
Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer.
Ovarian Neoplasms
Transcriptomic Characterization of Endometrioid, Clear Cell, and High-Grade Serous Epithelial Ovarian Carcinoma.
Ovarian Neoplasms
Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both MIRK/DYRK1B and p130/RB2.
Ovarian Neoplasms
Unfolded protein response mediated JNK/AP-1 signal transduction, a target for ovarian cancer treatment.
Ovarian Neoplasms
Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells.
Ovarian Neoplasms
Wip1 suppresses ovarian cancer metastasis through the ATM/AKT/Snail mediated signaling.
Ovarian Neoplasms
Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta.
Ovarian Neoplasms
[Correlations between the p-Akt-mTOR-p70S6K pathway and clinicopathological features or chemoresistance of ovarian cancer].
Ovarian Neoplasms
[Effects of chrysin on sphere formation and CK2? expression of ovarian cancer stem-like cells derived from SKOV3 cell line].
Ovarian Neoplasms
[Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]
Ovarian Neoplasms
[Glycogen synthase kinase-3beta (GSK-3beta) promotes proliferation of ovarian cancer cells in vitro]
Ovarian Neoplasms
[Reversal of drug resistance in human ovarian cancer cells by wild-type PTEN gene and its mechanisms]
Ovarian Neoplasms
[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms]
Ovarian Neoplasms
[Suppression of ATR reverses the cisplatin resistance in ovarian cancer SKOV3 cells].
Overnutrition
Maintenance of metabolic homeostasis by sestrin2 and sestrin3.
Overweight
Body fat partitioning does not explain the interethnic variation in insulin sensitivity among Asian ethnicity: the Singapore adults metabolism study.
Overweight
Stress kinases, endoplasmic reticulum stress, and Alzheimer's disease related markers in peripheral blood mononuclear cells from subjects with increased body weight.
Paget Disease, Extramammary
Expression of insulin-like growth factor-1 receptor, p-AKT and p-ERK1/2 protein in extramammary Paget's disease.
Paget Disease, Extramammary
Immunohistochemical analysis of the mammalian target of rapamycin signalling pathway in extramammary Paget's disease.
Pancreatic Cyst
Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts.
Pancreatic Neoplasms
14-3-3sigma Modulates pancreatic cancer cell survival and invasiveness.
Pancreatic Neoplasms
A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer.
Pancreatic Neoplasms
A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer.
Pancreatic Neoplasms
A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo.
Pancreatic Neoplasms
A phase II study to evaluate LY2603618 in combination with gemcitabine in pancreatic cancer patients.
Pancreatic Neoplasms
Aberrant expression of STYK1 and E-cadherin confer a poor prognosis for pancreatic cancer patients.
Pancreatic Neoplasms
Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.
Pancreatic Neoplasms
Activated Akt and Erk Expression and Survival After Surgery in Pancreatic Carcinoma.
Pancreatic Neoplasms
Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma.
Pancreatic Neoplasms
Activation of Akt2 Inhibits anoikis and apoptosis induced by myogenic differentiation.
Pancreatic Neoplasms
Activation of GLP-1 receptor enhances the chemosensitivity of pancreatic cancer cells.
Pancreatic Neoplasms
Activation of Raf-1 in human pancreatic adenocarcinoma.
Pancreatic Neoplasms
AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2.
Pancreatic Neoplasms
Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells.
Pancreatic Neoplasms
Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells.
Pancreatic Neoplasms
Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity.
Pancreatic Neoplasms
Association between ATM polymorphisms and cancer risk: a meta-analysis.
Pancreatic Neoplasms
Associations of novel variants in PIK3C3, INSR and MAP3K4 of the ATM pathway genes with pancreatic cancer risk.
Pancreatic Neoplasms
ATM mutations in patients with hereditary pancreatic cancer.
Pancreatic Neoplasms
Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer.
Pancreatic Neoplasms
Aurora kinases.
Pancreatic Neoplasms
Autophagy Induced by CX-4945, a Casein Kinase 2 Inhibitor, Enhances Apoptosis in Pancreatic Cancer Cell Lines.
Pancreatic Neoplasms
Bcl-2/Bcl-xL inhibitor navitoclax increases the antitumor effect of Chk1 inhibitor prexasertib by inducing apoptosis in pancreatic cancer cells via inhibition of Bcl-xL but not Bcl-2.
Pancreatic Neoplasms
c-Jun N-terminal kinase inhibitor SP600125 enhances barrier function and elongation of human pancreatic cancer cell line HPAC in a Ca-switch model.
Pancreatic Neoplasms
Casein kinase II inhibition induces apoptosis in pancreatic cancer cells.
Pancreatic Neoplasms
Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint.
Pancreatic Neoplasms
CHK1 inhibition sensitizes pancreatic cancer cells to gemcitabine via promoting CDK-dependent DNA damage and ribonucleotide reductase downregulation.
Pancreatic Neoplasms
Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse.
Pancreatic Neoplasms
Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells.
Pancreatic Neoplasms
Context Dependence of Checkpoint Kinase 1 as a Therapeutic Target for Pancreatic Cancers Deficient in the BRCA2 Tumor Suppressor.
Pancreatic Neoplasms
Correction: Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-mediated DNA Damage Response.
Pancreatic Neoplasms
Dasatinib can enhance paclitaxel and gemcitabine inhibitory activity in human pancreatic cancer cells.
Pancreatic Neoplasms
DCAMKL-1 Regulates Epithelial-Mesenchymal Transition in Human Pancreatic Cells through a miR-200a-Dependent Mechanism.
Pancreatic Neoplasms
Dermokine contributes to epithelial-mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer.
Pancreatic Neoplasms
Design and synthesis of an in vivo-efficacious PIM3 kinase inhibitor as a candidate anti-pancreatic cancer agent.
Pancreatic Neoplasms
Differential 14-3-3 sigma DNA methylation and expression in c-myc- and activated H-ras-transformed cells under r- and K-selection.
Pancreatic Neoplasms
Differential activity of GSK-3 isoforms regulates NF-?B and TRAIL- or TNF? induced apoptosis in pancreatic cancer cells.
Pancreatic Neoplasms
DNA-PKcs is important for Akt activation and gemcitabine resistance in PANC-1 pancreatic cancer cells.
Pancreatic Neoplasms
Docking and three-dimensional quantitative structure-activity relationship analyses of imidazole and thiazolidine derivatives as Aurora A kinase inhibitors.
Pancreatic Neoplasms
Downregulation of Human Endogenous Retrovirus Type K (HERV-K) Viral env RNA in Pancreatic Cancer Cells Decreases Cell Proliferation and Tumor Growth.
Pancreatic Neoplasms
Effect of a combination of S-1 and gemcitabine on cell cycle regulation in pancreatic cancer cell lines.
Pancreatic Neoplasms
Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: an in vivo and in vitro study.
Pancreatic Neoplasms
Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma.
Pancreatic Neoplasms
Elevated DNA damage response in pancreatic cancer.
Pancreatic Neoplasms
Elevation of intracellular cyclic adenosine monophosphate inhibits the epidermal growth factor signal transduction pathway and cellular growth in pancreatic adenocarcinoma cell lines.
Pancreatic Neoplasms
Endocrine gland?derived vascular endothelial growth factor modulates proliferation, apoptosis and migration in pancreatic cancer cells.
Pancreatic Neoplasms
Enhancing apoptosis and overcoming resistance of gemcitabine in pancreatic cancer with bortezomib: a role of death-associated protein kinase-related apoptosis-inducing protein kinase 1.
Pancreatic Neoplasms
Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells.
Pancreatic Neoplasms
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.
Pancreatic Neoplasms
Expression and significance of CD44 and p-AKT in pancreatic head cancer.
Pancreatic Neoplasms
Expression of CD44 in pancreatic cancer and its significance.
Pancreatic Neoplasms
Expression profiles for 14-3-3 zeta and CCL20 in pancreatic cancer and chronic pancreatitis.
Pancreatic Neoplasms
Familial pancreatic cancer: from genes to improved patient care.
Pancreatic Neoplasms
Familial pancreatic carcinoma in Jews.
Pancreatic Neoplasms
FHL3 Contributes to EMT and Chemotherapy Resistance Through Up-Regulation of Slug and Activation of TGF?/Smad-Independent Pathways in Gastric Cancer.
Pancreatic Neoplasms
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Pancreatic Neoplasms
Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.
Pancreatic Neoplasms
Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications.
Pancreatic Neoplasms
Glycogen Synthase Kinase-3 (GSK3) Inhibition Induces Prosurvival Autophagic Signals in Human Pancreatic Cancer Cells.
Pancreatic Neoplasms
Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy.
Pancreatic Neoplasms
Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response.
Pancreatic Neoplasms
Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis.
Pancreatic Neoplasms
Glycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression.
Pancreatic Neoplasms
Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma.
Pancreatic Neoplasms
Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells.
Pancreatic Neoplasms
Growth factors and cytokines in pancreatic carcinogenesis.
Pancreatic Neoplasms
Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway.
Pancreatic Neoplasms
GSK-3: An important kinase in colon and pancreatic cancers.
Pancreatic Neoplasms
GSK-3? Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals.
Pancreatic Neoplasms
GSK-3? in Pancreatic Cancer: Spotlight on 9-ING-41, Its Therapeutic Potential and Immune Modulatory Properties.
Pancreatic Neoplasms
GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer.
Pancreatic Neoplasms
High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma.
Pancreatic Neoplasms
Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants.
Pancreatic Neoplasms
Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer.
Pancreatic Neoplasms
Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.
Pancreatic Neoplasms
Human SMG-1 is Involved in Gemcitabine-Induced Primary microRNA-155/BIC Up-Regulation in Human Pancreatic Cancer PANC-1 Cells.
Pancreatic Neoplasms
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
Pancreatic Neoplasms
Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer.
Pancreatic Neoplasms
IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Pancreatic Neoplasms
Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.
Pancreatic Neoplasms
In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic cancer.
Pancreatic Neoplasms
Inherited pancreatic cancer syndromes.
Pancreatic Neoplasms
Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms.
Pancreatic Neoplasms
Inhibition of LONP1 Suppresses Pancreatic Cancer Progression Via c-Jun N-Terminal Kinase Pathway-Meditated Epithelial-Mesenchymal Transition.
Pancreatic Neoplasms
Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A.
Pancreatic Neoplasms
Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer.
Pancreatic Neoplasms
Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.
Pancreatic Neoplasms
Insulin-Like Growth Factor 1 Receptor (IGF-1R) as a Target of MiR-497 and Plasma IGF-1R Levels Associated with TNM Stage of Pancreatic Cancer.
Pancreatic Neoplasms
Integrin-linked kinase activity is associated with interleukin-1 alpha-induced progressive behavior of pancreatic cancer and poor patient survival.
Pancreatic Neoplasms
Kinase signaling pathways as targets for intervention in pancreatic cancer.
Pancreatic Neoplasms
Knockdown of PFTK1 inhibits tumor cell proliferation, invasion and epithelial-to-mesenchymal transition in pancreatic cancer.
Pancreatic Neoplasms
Light-emitting diode irradiation induces AKT/mTOR-mediated apoptosis in human pancreatic cancer cells and xenograft mouse model.
Pancreatic Neoplasms
Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway.
Pancreatic Neoplasms
Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.
Pancreatic Neoplasms
Measurement of Protein Kinase B Activity in Single Primary Human Pancreatic Cancer Cells.
Pancreatic Neoplasms
micorRNA-101 silences DNA-PKcs and sensitizes pancreatic cancer cells to gemcitabine.
Pancreatic Neoplasms
MiR-142-3p targeting NUCKS1 inhibits proliferation and invasion of pancreatic cancer cells.
Pancreatic Neoplasms
miR-208-Induced Epithelial to Mesenchymal Transition of Pancreatic Cancer Cells Promotes Cell Metastasis and Invasion.
Pancreatic Neoplasms
Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer.
Pancreatic Neoplasms
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Pancreatic Neoplasms
Mitofusin2 Induces Cell Autophagy of Pancreatic Cancer through Inhibiting the PI3K/Akt/mTOR Signaling Pathway.
Pancreatic Neoplasms
MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases.
Pancreatic Neoplasms
Molecular aspects of pancreatic cancer and future perspectives.
Pancreatic Neoplasms
Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5.
Pancreatic Neoplasms
Notch signaling via regulation of RB and p-AKT but not PIK3CG contributes to MIA PaCa-2 cell growth and migration to affect pancreatic carcinogenesis.
Pancreatic Neoplasms
Oridonin induces autophagy-mediated cell death in pancreatic cancer by activating the c-Jun N-terminal kinase pathway and inhibiting phosphoinositide 3-kinase signaling.
Pancreatic Neoplasms
Overview of linkage analysis: application to pancreatic cancer.
Pancreatic Neoplasms
p21-Activated Kinase 4 (PAK4) as a Predictive Marker of Gemcitabine Sensitivity in Pancreatic Cancer Cell Lines.
Pancreatic Neoplasms
PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration.
Pancreatic Neoplasms
Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib response.
Pancreatic Neoplasms
Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice.
Pancreatic Neoplasms
Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.
Pancreatic Neoplasms
Phosph-Akt1 expression is associated with a favourable prognosis in pancreatic cancer.
Pancreatic Neoplasms
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.
Pancreatic Neoplasms
Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer.
Pancreatic Neoplasms
Prexasertib increases the sensitivity of pancreatic cancer cells to gemcitabine and S?1.
Pancreatic Neoplasms
Primate-specific miRNA-637 inhibited tumorigenesis in human pancreatic ductal adenocarcinoma cells by suppressing Akt1 expression.
Pancreatic Neoplasms
Primers on molecular pathways. The glycogen synthase kinase-3beta.
Pancreatic Neoplasms
Prognostic value of p21-activated kinase 4 in resected pancreatic cancer.
Pancreatic Neoplasms
Progress in cancer genetics: lessons from pancreatic cancer.
Pancreatic Neoplasms
Protein kinase D enzymes: novel kinase targets in pancreatic cancer.
Pancreatic Neoplasms
Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells.
Pancreatic Neoplasms
Protein kinase D1 regulates metabolic switch in pancreatic cancer via modulation of mTORC1.
Pancreatic Neoplasms
Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases.
Pancreatic Neoplasms
Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover.
Pancreatic Neoplasms
RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Pancreatic Neoplasms
Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer.
Pancreatic Neoplasms
Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells.
Pancreatic Neoplasms
Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells.
Pancreatic Neoplasms
RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.
Pancreatic Neoplasms
ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells.
Pancreatic Neoplasms
ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1.
Pancreatic Neoplasms
Role of protein kinase D signaling in pancreatic cancer.
Pancreatic Neoplasms
Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells.
Pancreatic Neoplasms
S100A11 promotes human pancreatic cancer PANC-1 cell proliferation and is involved in the PI3K/AKT signaling pathway.
Pancreatic Neoplasms
Secretion of MUC5AC mucin from pancreatic cancer cells in response to forskolin and VIP.
Pancreatic Neoplasms
Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.
Pancreatic Neoplasms
Sensitization of Pancreatic Cancer to Chemoradiation by the Chk1 Inhibitor MK8776.
Pancreatic Neoplasms
ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer.
Pancreatic Neoplasms
STING (or SRC) Like an ICB: Priming the Immune Response in Pancreatic Cancer.
Pancreatic Neoplasms
STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1?.
Pancreatic Neoplasms
Synergistic Anti-Cancer Effects of AKT and SRC Inhibition in Human Pancreatic Cancer Cells.
Pancreatic Neoplasms
Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold.
Pancreatic Neoplasms
Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.
Pancreatic Neoplasms
Targeting X-linked inhibitor of apoptosis protein inhibits pancreatic cancer cell growth through p-Akt depletion.
Pancreatic Neoplasms
The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK.
Pancreatic Neoplasms
The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells.
Pancreatic Neoplasms
Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.
Pancreatic Neoplasms
Translational research in pancreatic cancer. Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010.
Pancreatic Neoplasms
Triciribine Phosphate Monohydrate, an AKT Inhibitor, Enhances Gemcitabine Activity in Pancreatic Cancer Cells.
Pancreatic Neoplasms
Type I collagen and divalent cation shifts disrupt cell-cell adhesion, increase migration, and decrease PTHrP, IL-6, and IL-8 expression in pancreatic cancer cells.
Pancreatic Neoplasms
Widely metastatic atypical pituitary adenoma with mTOR pathway STK11(F298L) mutation treated with everolimus therapy.
Pancreatic Neoplasms
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines.
Pancreatitis
A NOVEL PROTEIN KINASE D INHIBITOR ATTENUATES EARLY EVENTS OF EXPERIMENTAL PANCREATITIS IN ISOLATED RAT ACINI.
Pancreatitis
Effects of baicalin on inflammatory reaction, oxidative stress and PKDl and NF-kB protein expressions in rats with severe acute pancreatitis1.
Pancreatitis
Effects of Berberine on Acute Necrotizing Pancreatitis and Associated Lung Injury.
Pancreatitis
Effects of emodin on intestinal mucosal barrier by the upregulation of miR-218a-5p expression in rats with acute necrotizing pancreatitis.
Pancreatitis
Effects of glycogen synthase kinase-3beta inhibition on the development of cerulein-induced acute pancreatitis in mice*
Pancreatitis
Effects of glycogen synthase kinase-3beta inhibition on the development of cerulein-induced acute pancreatitis in mice.
Pancreatitis
Eupatilin Ameliorates Cerulein-Induced Pancreatitis Via Inhibition of the Protein Kinase D1 Signaling Pathway In Vitro.
Pancreatitis
Familial pancreatic carcinoma in Jews.
Pancreatitis
Glycogen synthase kinase-3 beta inhibitors protectagainst the acute lung injuries resulting from acute necrotizing pancreatitis.
Pancreatitis
Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation.
Pancreatitis
Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG12D/Pdx-1-Cre Mice.
Pancreatitis
Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis.
Pancreatitis
MIP-1? induces inflammatory responses by upregulating chemokine receptor 1/chemokine receptor 5 and activating c-Jun N-terminal kinase and mitogen-activated protein kinase signaling pathways in acute pancreatitis.
Pancreatitis
MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury.
Pancreatitis
Novel Small Molecule Inhibitors of Protein Kinase D Suppress NF-kappaB Activation and Attenuate the Severity of Rat Cerulein Pancreatitis.
Pancreatitis
Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis.
Pancreatitis
Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.
Pancreatitis
Protein kinase d regulates cell death pathways in experimental pancreatitis.
Pancreatitis
Rolipram and SP600125 Suppress the Early Increase in PTP1B Expression During Cerulein-Induced Pancreatitis in Rats.
Pancreatitis, Acute Necrotizing
Glycogen synthase kinase-3 beta inhibitors protectagainst the acute lung injuries resulting from acute necrotizing pancreatitis.
Pancreatitis, Acute Necrotizing
Nobiletin protects against murine l-arginine-induced acute pancreatitis in association with downregulating p38MAPK and AKT.
Pancreatitis, Chronic
Expression profiles for 14-3-3 zeta and CCL20 in pancreatic cancer and chronic pancreatitis.
Pancreatitis, Chronic
LY294002 enhances inhibitory effect of gemcitabine on proliferation of human pancreatic carcinoma PANC-1 cells.
Papilloma
Activated Akt-1 in specific cell populations during multi-stage skin carcinogenesis.
Papilloma
Gastric-type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances.
Papilloma
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Papilloma
Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS.
Papilloma
Murine gammaherpesvirus 68 ORF75c contains ubiquitin E3 ligase activity and requires PML SUMOylation but not other known cellular PML regulators, CK2 and E6AP, to mediate PML degradation.
Papilloma
Phosphatidylinositol 3-kinase regulates early differentiation in human laryngeal keratinocytes.
Papilloma
Progression of naive intraepithelial neoplasia genome to aggressive squamous cell carcinoma genome of uterine cervix.
Papilloma
Role of Human papilloma virus Infection and Altered Methylation of Specific Genes in Esophageal Cancer.
Papilloma
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development.
Papilloma, Choroid Plexus
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Papillomavirus Infections
A tumor of the uterine cervix with a complex histology in a Peutz-Jeghers syndrome patient with genomic deletion of the STK11 exon 1 region.
Papillomavirus Infections
Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival.
Papillomavirus Infections
Expression of P-Akt, NFkappaB and their correlation with human papillomavirus infection in cervical carcinoma.
Papillomavirus Infections
Human papillomavirus and gene mutations in head and neck squamous carcinomas.
Papillomavirus Infections
Role of Human papilloma virus Infection and Altered Methylation of Specific Genes in Esophageal Cancer.
Papillomavirus Infections
Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer.
Papillomavirus Infections
[Correlation of HIPK2 expression with HPV infection and apoptosis in cervical cancer]
Paralysis
A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy.
Paralysis
Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease.
Paralysis
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Paralysis
Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.
Paralysis
Evidence for irreversible inhibition of glycogen synthase kinase-3? by tideglusib.
Paralysis
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.
Paralysis
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Paralysis
LRRK2 and survival in progressive supranuclear palsy.
Paralysis
LRRK2 p.Ile1371Val Mutation in a Case with Neuropathologically Confirmed Multi-System Atrophy.
Paralysis
Lrrk2 R1441 substitution and progressive supranuclear palsy.
Paralysis
Pharmacophore feature-based virtual screening for finding potent GSK-3 inhibitors using molecular docking and dynamics simulations.
Paralysis
Randomized placebo-controlled trial of sodium valproate in progressive supranuclear palsy.
Paralysis
Screening for LRRK2 R1441 mutations in a cohort of PSP patients from Germany.
Paralysis
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Paralysis
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration.
Paralysis
Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial.
Paralysis
[Clinical molecular genetics for PARK8 (LRRK2)]
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Paramyxoviridae Infections
Parainfluenza virus 5 m protein interaction with host protein 14-3-3 negatively affects virus particle formation.
Paramyxoviridae Infections
Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II.
Paramyxoviridae Infections
Viral strategies for triggering and manipulating mitophagy.
Paraplegia
Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma.
Parasitemia
High levels of IgE autoantibody to 14-3-3 epsilon protein correlate with protection against severe Plasmodium falciparum malaria.
Parasitic Diseases
Assignment of the casein kinase II gene family to cattle chromosomes.
Parasitic Diseases
Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases.
Parathyroid Neoplasms
A proteomic approach to study parathyroid glands.
Parathyroid Neoplasms
Calmodulin and calmodulin-dependent protein kinase II (CaMKII) inhibit hormone secretion in human parathyroid adenoma.
Paresis
Creutzfeldt-Jakob disease with initial right hemiparesis masquerading as a stroke.
Parkinson Disease
"LRRK2: Autophagy and Lysosomal Activity".
Parkinson Disease
(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.
Parkinson Disease
(R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model.
Parkinson Disease
1-Pyrazolyl-5,6-Disubstituted Indazole Derivatives as LRRK2 Inhibitors for Treating Parkinson's Disease.
Parkinson Disease
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.
Parkinson Disease
14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3? overexpression promotes recovery in the MPTP mouse model of Parkinson's disease.
Parkinson Disease
14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains.
Parkinson Disease
14-3-3 proteins in neurodegeneration.
Parkinson Disease
14-3-3 Proteins in the Regulation of Rotenone-Induced Neurotoxicity Might be via Its Isoform 14-3-3Epsilon's Involvement in Autophagy.
Parkinson Disease
14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic ?-Synuclein.
Parkinson Disease
14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
Parkinson Disease
14-3-3theta Protects against Neurotoxicity in a Cellular Parkinson's Disease Model through Inhibition of the Apoptotic Factor Bax.
Parkinson Disease
18F-Labelled pyrrolopyrimidines reveal brain leucine-rich repeat kinase 2 expression implicated in Parkinson's disease.
Parkinson Disease
6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
Parkinson Disease
68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment.
Parkinson Disease
?-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain.
Parkinson Disease
?-synuclein, LRRK2 and their interplay in Parkinson's disease.
Parkinson Disease
A case of restless leg syndrome in a family with LRRK2 gene mutation.
Parkinson Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Parkinson Disease
A clinic-based screening of mutations in exons 31, 34, 35, 41, and 48 of LRRK2 in Iranian Parkinson's disease patients.
Parkinson Disease
A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations.
Parkinson Disease
A clinical, neuropsychological and olfactory evaluation of a large family with LRRK2 mutations.
Parkinson Disease
A cognitive fMRI study in non-manifesting LRRK2 and GBA carriers.
Parkinson Disease
A common leucine-rich repeat kinase 2 gene mutation in familial and sporadic Parkinson's disease in Russia.
Parkinson Disease
A common LRRK2 mutation in idiopathic Parkinson's disease.
Parkinson Disease
A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan.
Parkinson Disease
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
Parkinson Disease
A comparative study of Lrrk2 function in primary neuronal cultures.
Parkinson Disease
A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson disease.
Parkinson Disease
A comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism.
Parkinson Disease
A Comprehensive Analysis of Population Differences in LRRK2 Variant Distribution in Parkinson's Disease.
Parkinson Disease
A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity.
Parkinson Disease
A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2.
Parkinson Disease
A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation.
Parkinson Disease
A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson's Disease in Participants With Leucine-Rich Repeat Kinase 2 Mutation.
Parkinson Disease
A founding LRRK2 haplotype shared by Tunisian, US, European and Middle Eastern families with Parkinson's disease.
Parkinson Disease
A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.
Parkinson Disease
A genetic analysis of a Spanish population with early onset Parkinson's disease.
Parkinson Disease
A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry.
Parkinson Disease
A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.
Parkinson Disease
A Korean Parkinson's disease family with the LRRK2 p.Tyr1699Cys mutation showing clinical heterogeneity.
Parkinson Disease
A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.
Parkinson Disease
A liquid phase based C. elegans behavioral analysis system identifies motor activity loss in a nematode Parkinson's disease model.
Parkinson Disease
A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype.
Parkinson Disease
A More Homogeneous Phenotype in Parkinson's Disease Related to R1441G Mutation in the LRRK2 Gene.
Parkinson Disease
A natural product from Cannabis sativa subsp. sativa inhibits homeodomain-interacting protein kinase 2 (HIPK2), attenuating MPP
Parkinson Disease
A new approach to analysis of intracellular proteins and subcellular localization using cellprofiler and imageJ in combination.
Parkinson Disease
A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease models.
Parkinson Disease
A novel LRRK2 mutation in a mainland Chinese patient with familial Parkinson's disease.
Parkinson Disease
A novel LRRK2 mutation in an Austrian cohort of patients with Parkinson's disease.
Parkinson Disease
A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson's Disease Affects LRRK2 Protein Levels.
Parkinson Disease
A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Parkinson Disease
A novel P755L mutation in LRRK2 gene associated with Parkinson's disease.
Parkinson Disease
A novel rare variant of LRRK2 associated with familial Parkinson's disease: p.R1501W.
Parkinson Disease
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Parkinson Disease
A Possible Modifying Effect of the G2019S Mutation in the LRRK2 Gene on GBA Parkinson's Disease.
Parkinson Disease
A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway.
Parkinson Disease
A Proteomics Approach to Investigate miR-153-3p and miR-205-5p Targets in Neuroblastoma Cells.
Parkinson Disease
A QUICK screen for Lrrk2 interaction partners - leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.
Parkinson Disease
A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.
Parkinson Disease
A selective small-molecule inhibitor of c-Jun N-terminal kinase 1.
Parkinson Disease
A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases.
Parkinson Disease
A stress-free strategy to correct point mutations in patient iPS cells.
Parkinson Disease
A study of LRRK2 mutations and Parkinson's disease in Brazil.
Parkinson Disease
A study of six point mutation analysis of LRRK2 gene in Chinese mainland patients with Parkinson's disease.
Parkinson Disease
A trojan horse for Parkinson's disease.
Parkinson Disease
A Virtual Cohort Study of Individuals at Genetic Risk for Parkinson's Disease: Study Protocol and Design.
Parkinson Disease
A visual review of the interactome of LRRK2: Using deep-curated molecular interactions data to represent biology.
Parkinson Disease
Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes.
Parkinson Disease
Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2R1441G mice.
Parkinson Disease
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Parkinson Disease
Abrogation of ?-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.
Parkinson Disease
Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.
Parkinson Disease
Absence of commonly reported leucine-rich repeat kinase 2 mutations in eastern Indian Parkinson's disease patients.
Parkinson Disease
Absence/rarity of commonly reported LRRK2 mutations in Indian Parkinson's disease patients.
Parkinson Disease
Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease.
Parkinson Disease
Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease.
Parkinson Disease
Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease.
Parkinson Disease
Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease.
Parkinson Disease
Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.
Parkinson Disease
Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.
Parkinson Disease
Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants.
Parkinson Disease
Age at Onset of Parkinson's Disease Among Ashkenazi Jewish Patients: Contribution of Environmental Factors, LRRK2 p.G2019S and GBA p.N370S Mutations.
Parkinson Disease
Age-dependent accumulation of oligomeric SNCA/?-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Parkinson Disease
Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen.
Parkinson Disease
Age-dependent dopamine transporter dysfunction and Serine129 phospho-?-synuclein overload in G2019S LRRK2 mice.
Parkinson Disease
Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.
Parkinson Disease
AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression.
Parkinson Disease
Age-related LRRK2 G2019S Mutation Impacts Microglial Dopaminergic Fiber Refinement and Synaptic Pruning Involved in Abnormal Behaviors.
Parkinson Disease
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum.
Parkinson Disease
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Parkinson Disease
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homologue by conformation-specific Nanobodies.
Parkinson Disease
Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson's Disease.
Parkinson Disease
alpha-synuclein and LRRK2: partners in crime.
Parkinson Disease
Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.
Parkinson Disease
Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease.
Parkinson Disease
Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation.
Parkinson Disease
Altered intrinsic brain functional connectivity in drug-naïve Parkinson's disease patients with LRRK2 mutations.
Parkinson Disease
Altered reward-related neural responses in non-manifesting carriers of the Parkinson disease related LRRK2 mutation.
Parkinson Disease
Alternative to LRRK2-IN-1 for Pharmacological Studies of Parkinson's Disease.
Parkinson Disease
Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.
Parkinson Disease
AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease.
Parkinson Disease
An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson's Disease and G2019S LRRK2 Cohorts.
Parkinson Disease
An association analysis of the R1628P and G2385R polymorphisms of the LRRK2 gene in multiple system atrophy in a Chinese population.
Parkinson Disease
An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease.
Parkinson Disease
An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.
Parkinson Disease
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.
Parkinson Disease
An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant.
Parkinson Disease
An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.
Parkinson Disease
Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease.
Parkinson Disease
Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.
Parkinson Disease
Analysis of Leucine-rich repeat kinase 2 (LRRK2) and Parkinson protein 2 (parkin, PARK2) genes mutations in Slovak Parkinson disease patients.
Parkinson Disease
Analysis of LRRK 2 G 2019 S and I 2020 T mutations in Parkinson's disease.
Parkinson Disease
Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations.
Parkinson Disease
Analysis of LRRK2 functional domains in nondominant Parkinson disease.
Parkinson Disease
Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.
Parkinson Disease
Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.
Parkinson Disease
Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson's Disease Susceptibility in Chinese Han Population.
Parkinson Disease
Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease.
Parkinson Disease
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
Parkinson Disease
Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.
Parkinson Disease
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.
Parkinson Disease
Analysis of the LRRK2 Gly2385Arg variant in Alzheimer's disease in Taiwan.
Parkinson Disease
Analysis of the LRRK2 Gly2385Arg variant in primary dystonia and multiple system atrophy in Taiwan.
Parkinson Disease
Analysis of the LRRK2 p.G2019S mutation in Colombian Parkinson's Disease Patients.
Parkinson Disease
Anatomical localization of leucine-rich repeat kinase 2 in mouse brain.
Parkinson Disease
Ancient origin of the Parkinson disease gene LRRK2.
Parkinson Disease
Apoptotic mechanisms in mutant LRRK2-mediated cell death.
Parkinson Disease
ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2.
Parkinson Disease
ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2.
Parkinson Disease
Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.
Parkinson Disease
Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries.
Parkinson Disease
Aspirin and ibuprofen could lower risk of LRRK2 Parkinson disease.
Parkinson Disease
Assaying the kinase activity of LRRK2 in vitro.
Parkinson Disease
Assessment of risk factor variants of LRRK2, MAPT, SNCA and TCEANC2 genes in Hungarian sporadic Parkinson's disease patients.
Parkinson Disease
Association between G2385R and R1628P polymorphism of LRRK2 gene and sporadic Parkinson's disease in a Han-Chinese population in south-eastern China.
Parkinson Disease
Association between Parkinson's disease and G2019S and R1441C mutations of the LRRK2 gene.
Parkinson Disease
Association of caffeine and related analytes with resistance to Parkinson's disease among LRRK2 mutation carriers: A metabolomic study.
Parkinson Disease
Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression.
Parkinson Disease
Association of GWAS loci with PD in China.
Parkinson Disease
Association of leucine-rich repeat kinase 2 gene rs10878307 polymorphism and Parkinson's disease risk in South India-A meta-analysis and molecular dynamics simulation.
Parkinson Disease
Association of LRRK2 and GBA mutations in a Brazilian family with Parkinson's disease.
Parkinson Disease
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Parkinson Disease
Association of LRRK2 Haplotype With Age at Onset in Parkinson Disease.
Parkinson Disease
Association of LRRK2 R1628P variant with Parkinson's disease in Ethnic Han-Chinese and subgroup population.
Parkinson Disease
Association of rare variants in neurodegenerative genes with familial Alzheimer's disease.
Parkinson Disease
Association of Subthalamic Deep Brain Stimulation With Motor, Functional, and Pharmacologic Outcomes in Patients With Monogenic Parkinson Disease: A Systematic Review and Meta-analysis.
Parkinson Disease
Association of ZNF184, IL1R2, LRRK2, ITPKB, and PARK16 with sporadic Parkinson's disease in Eastern China.
Parkinson Disease
Astrocytic atrophy as a pathological feature of Parkinson's disease with LRRK2 mutation.
Parkinson Disease
ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?
Parkinson Disease
Autonomic dysfunction in parkinsonian LRRK2 mutation carriers.
Parkinson Disease
Autophagy and innate immunity: Insights from invertebrate model organisms.
Parkinson Disease
Autophagy and LRRK2 in the Aging Brain.
Parkinson Disease
Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases.
Parkinson Disease
Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities.
Parkinson Disease
Autosomal dominant Parkinson's disease: Incidence of mutations in LRRK2, SNCA, VPS35 and GBA genes in Brazil.
Parkinson Disease
Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease.
Parkinson Disease
Behavioral Deficits and Striatal DA Signaling in LRRK2 p.G2019S Transgenic Rats: A Multimodal Investigation Including PET Neuroimaging.
Parkinson Disease
Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.
Parkinson Disease
Biochemical and kinetic properties of the complex Roco G-protein cycle.
Parkinson Disease
Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.
Parkinson Disease
Biochemical and pathological characterization of Lrrk2.
Parkinson Disease
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.
Parkinson Disease
Biochemical markers for severity and risk in GBA and LRRK2 Parkinson's disease.
Parkinson Disease
Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3) attenuates dopaminergic neuronal damage in mouse model of Parkinson's disease.
Parkinson Disease
BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice.
Parkinson Disease
Brain injury induces HIF-1?-dependent transcriptional activation of LRRK2 that exacerbates brain damage.
Parkinson Disease
Brain Penetrant LRRK2 Inhibitor.
Parkinson Disease
Brain transcriptomic profiling in idiopathic and LRRK2-associated Parkinson's disease.
Parkinson Disease
Brain-derived neurotrophic factor (BDNF) genetic polymorphism greatly increases risk of leucine-rich repeat kinase 2 (LRRK2) for Parkinson's disease.
Parkinson Disease
CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.
Parkinson Disease
Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.
Parkinson Disease
Caenorhabditis elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth.
Parkinson Disease
CaMKII inhibition ameliorated levodopa-induced dyskinesia by downregulating tyrosine hydroxylase activity in an experimental model of Parkinson's disease.
Parkinson Disease
Can the increasing number of newly developed leucine-rich repeat kinase 2 inhibitors validate or invalidate a potential disease-modifying therapeutic approach for Parkinson's disease?
Parkinson Disease
Cancer and Parkinson's disease: the odd couple.
Parkinson Disease
Carriers of both GBA and LRRK2 mutations, compared to carriers of either, in Parkinson's disease: Risk estimates and genotype-phenotype correlations.
Parkinson Disease
Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease.
Parkinson Disease
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Parkinson Disease
Caught in the act: LRRK2 in exosomes.
Parkinson Disease
Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes.
Parkinson Disease
Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.
Parkinson Disease
Cellular processes associated with LRRK2 function and dysfunction.
Parkinson Disease
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients.
Parkinson Disease
CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.
Parkinson Disease
Cerebral Imaging Markers of GBA and LRRK2 Related Parkinson's Disease and Their First-Degree Unaffected Relatives.
Parkinson Disease
Cerebrospinal fluid amyloid ? and tau in LRRK2 mutation carriers.
Parkinson Disease
Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers.
Parkinson Disease
Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.
Parkinson Disease
Changes to Intermediary Metabolites in Sporadic and LRRK2 Parkinson's Disease Demonstrated by Proton Magnetic Resonance Spectroscopy.
Parkinson Disease
Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.
Parkinson Disease
Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases.
Parkinson Disease
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.
Parkinson Disease
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.
Parkinson Disease
Characterization of Parkinson's disease-related pathogenic TMEM230 mutants.
Parkinson Disease
Characterization of PINK1 processing, stability, and subcellular localization.
Parkinson Disease
Characterization of TAE684 as a potent LRRK2 kinase inhibitor.
Parkinson Disease
Characterization of the Roco protein family in Dictyostelium discoideum.
Parkinson Disease
Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.
Parkinson Disease
Chetomin rescues pathogenic phenotype of LRRK2 mutation in drosophila.
Parkinson Disease
Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons.
Parkinson Disease
Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers.
Parkinson Disease
Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study.
Parkinson Disease
Clinical and Pathological Characteristics of LRRK2 G2019S Patients with PD.
Parkinson Disease
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.
Parkinson Disease
Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.
Parkinson Disease
Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel.
Parkinson Disease
Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan.
Parkinson Disease
Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease.
Parkinson Disease
Clinical expression of LRRK2 G2019S mutations in the elderly.
Parkinson Disease
Clinical Features of LRRK2 Carriers with Parkinson's Disease.
Parkinson Disease
Clinical features of LRRK2 parkinsonism.
Parkinson Disease
Clinical features of LRRK2-associated Parkinson's disease in central Norway.
Parkinson Disease
Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations.
Parkinson Disease
Clinical Heterogeneity Among LRRK2 Variants in Parkinson's Disease: A Meta-Analysis.
Parkinson Disease
Clinical heterogeneity of LRRK2 p.I2012T mutation.
Parkinson Disease
Clinical heterogeneity of the LRRK2 G2019S mutation.
Parkinson Disease
Clinical Phenotype of LRRK2 R1441C in 2 Chinese Sisters.
Parkinson Disease
Clinical profiles associated with LRRK2 and GBA mutations in Brazilians with Parkinson's disease.
Parkinson Disease
Clinical profiles of Parkinson's disease associated with common leucine-rich repeat kinase 2 and glucocerebrosidase genetic variants in Chinese individuals.
Parkinson Disease
Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD.
Parkinson Disease
Clinicians' attitudes toward general screening of the Ashkenazi-Jewish population for prevalent founder BRCA1/2 and LRRK2 mutations.
Parkinson Disease
Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.
Parkinson Disease
Clustering of motor and nonmotor traits in leucine-rich repeat kinase 2 G2019S Parkinson's disease nonparkinsonian relatives: A multicenter family study.
Parkinson Disease
Co-occurrence of sporadic parkinsonism and late-onset Alzheimer's disease in a Brazilian male with the LRRK2 p.G2019S mutation.
Parkinson Disease
Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.
Parkinson Disease
Cognitive and behavioral symptoms in Parkinson's disease patients with the G2019S and R1441G mutations of the LRRK2 gene.
Parkinson Disease
Cognitive dysfunction in Parkinson's disease related to the R1441G mutation in LRRK2.
Parkinson Disease
Cognitive dysfunction in Tunisian LRRK2 associated Parkinson's disease.
Parkinson Disease
Cognitive enhancement, TAU phosphorylation reduction, and neuronal protection by the treatment of an LRRK2 inhibitor in a tauopathy mouse model.
Parkinson Disease
Cognitive Impairments in LRRK2-Related Parkinson's Disease: A Study in Chinese Individuals.
Parkinson Disease
Cognitive profile and 18F-fluorodeoxyglucose PET study in LRRK2-related Parkinson's disease.
Parkinson Disease
Combined Knockout of Lrrk2 and Rab29 Does Not Result in Behavioral Abnormalities in vivo.
Parkinson Disease
Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.
Parkinson Disease
Common variants of LRRK2 are not associated with sporadic Parkinson's disease.
Parkinson Disease
Common variation in the LRRK2 gene is a risk factor for Parkinson's disease.
Parkinson Disease
Comparative analysis of Parkinson's disease-associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons.
Parkinson Disease
Comparative blood transcriptome analysis in idiopathic and LRRK2 G2019S-associated Parkinson's disease.
Parkinson Disease
Comparison of an Online-Only Parkinson's Disease Research Cohort to Cohorts Assessed In Person.
Parkinson Disease
Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls.
Parkinson Disease
Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease.
Parkinson Disease
Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease.
Parkinson Disease
Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies.
Parkinson Disease
Comprehensive LRRK2 and GBA screening in Portuguese patients with Parkinson's disease: Identification of a new family with the LRRK2 p.Arg1441His mutation and novel missense variants.
Parkinson Disease
Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease.
Parkinson Disease
Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation.
Parkinson Disease
Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa.
Parkinson Disease
Computational analysis of the LRRK2 interactome.
Parkinson Disease
Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.
Parkinson Disease
Confirmation of LRRK2 S1647T variant as a risk factor for Parkinson's disease in Southern China.
Parkinson Disease
Confirmation of the association between LRRK2 R1628P variant and susceptibility to Parkinson's disease in the Thai population.
Parkinson Disease
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.
Parkinson Disease
Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo.
Parkinson Disease
Contribution of GTPase activity to LRRK2-associated Parkinson disease.
Parkinson Disease
Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5.
Parkinson Disease
Correction: Phosphorylation-Dependent 14-3-3 Binding to LRRK2 Is Impaired by Common Mutations of Familial Parkinson's Disease.
Parkinson Disease
Correction: S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
Parkinson Disease
Correlation between LRRK2 gene G2385R polymorphisms and Parkinson's disease.
Parkinson Disease
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Parkinson Disease
CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and ?-Synuclein modulation in dopaminergic neurons.
Parkinson Disease
Crohn's and Parkinson disease: is LRRK2 lurking around the corner?
Parkinson Disease
Cross-talk between LRRK2 and PKA: implication for Parkinson's disease?
Parkinson Disease
Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes.
Parkinson Disease
Crystal structure of the WD40 domain dimer of LRRK2.
Parkinson Disease
CSF lamp2 concentrations are decreased in female Parkinson's disease patients with LRRK2 mutations.
Parkinson Disease
CSF Nrf2 and HSPA8 in Parkinson's disease patients with and without LRRK2 gene mutations.
Parkinson Disease
CSF total and oligomeric ?-Synuclein along with TNF-? as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers.
Parkinson Disease
Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway.
Parkinson Disease
Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design.
Parkinson Disease
Cytogenetic Analysis of the Results of Genome Editing on the Cell Model of Parkinson's Disease.
Parkinson Disease
Death-associated protein kinase 1 variation and Parkinson's disease.
Parkinson Disease
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
Parkinson Disease
Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1.
Parkinson Disease
Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe.
Parkinson Disease
Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis.
Parkinson Disease
DEGAS: de novo discovery of dysregulated pathways in human diseases.
Parkinson Disease
Degradation of LRRK2 in the Treatment of Parkinson's Disease.
Parkinson Disease
Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain.
Parkinson Disease
Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect.
Parkinson Disease
Derivation of human induced pluripotent stem cell (iPSC) line with LRRK2 gene R1398H variant in Parkinson's disease.
Parkinson Disease
Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations.
Parkinson Disease
Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
Parkinson Disease
Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
Parkinson Disease
Design, synthesis, and evaluation of a selective chemosensor for leucine-rich repeat kinase 2.
Parkinson Disease
Development and biological evaluation of[18F]FMN3PA & [18F]FMN3PU for leucine-rich repeat kinase 2 (LRRK2) in vivo PET imaging.
Parkinson Disease
Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene.
Parkinson Disease
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites.
Parkinson Disease
Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation.
Parkinson Disease
Development of Inducible Leucine-rich Repeat Kinase 2 (LRRK2) Cell Lines for Therapeutics Development in Parkinson's Disease.
Parkinson Disease
Development of LRRK2 Inhibitors for the Treatment of Parkinson's Disease.
Parkinson Disease
Development of phospho-specific Rab protein antibodies to monitor
Parkinson Disease
Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.
Parkinson Disease
Dexamethasone induces the expression of LRRK2 and ?-synuclein, two genes that when mutated cause Parkinson's disease in an autosomal dominant manner.
Parkinson Disease
Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹??¹G) transgenic mouse.
Parkinson Disease
Dietary Amino Acids Impact LRRK2-Induced Neurodegeneration in Parkinson's Disease Models.
Parkinson Disease
Differences in MTHFR and LRRK2 variant's association with sporadic Parkinson's disease in Mexican Mestizos correlated to Native American ancestry.
Parkinson Disease
Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2.
Parkinson Disease
Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).
Parkinson Disease
Differential Effects of Familial Parkinson Mutations in LRRK2 Revealed by a Systematic Analysis of Autophosphorylation.
Parkinson Disease
Differential Inhibition of LRRK2 in Parkinson's Disease Patient Blood by a G2019S Selective LRRK2 Inhibitor.
Parkinson Disease
Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.
Parkinson Disease
Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.
Parkinson Disease
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Parkinson Disease
Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity.
Parkinson Disease
Disclosure of research results in genetic studies of Parkinson's disease caused by LRRK2 mutations.
Parkinson Disease
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Parkinson Disease
Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors.
Parkinson Disease
Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor.
Parkinson Disease
Discovery of Highly Potent, Selective and Brain Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors.
Parkinson Disease
Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.
Parkinson Disease
Discovery of LRRK2 inhibitors by using an ensemble of virtual screening methods.
Parkinson Disease
Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.
Parkinson Disease
Discrimination of Parkinson-associated LRRK2 alleles by introduction of a single nucleotide mismatch into siRNA.
Parkinson Disease
Disruption of LRRK2 does not cause specific loss of dopaminergic neurons in zebrafish.
Parkinson Disease
Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response.
Parkinson Disease
Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations.
Parkinson Disease
Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells.
Parkinson Disease
Distinctive roles of Rac1 and Rab29 in LRRK2 mediatedmembrane trafficking and neurite outgrowth.
Parkinson Disease
Distribution of PINK1 and LRRK2 in rat and mouse brain.
Parkinson Disease
Divergent ?-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.
Parkinson Disease
Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.
Parkinson Disease
Diversity in the regulation of autophagy and mitophagy: lessons from Parkinson's disease.
Parkinson Disease
DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study.
Parkinson Disease
Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?
Parkinson Disease
Does Uncoupling Protein 2 Expression Qualify as Marker of Disease Status in LRRK2-Associated Parkinson's Disease?
Parkinson Disease
Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation.
Parkinson Disease
Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease.
Parkinson Disease
Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.
Parkinson Disease
Dopamine neuron-specific LRRK2 G2019S effects on gene expression revealed by translatome profiling.
Parkinson Disease
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
Parkinson Disease
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
Parkinson Disease
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Parkinson Disease
Drosophila hep pathway mediates Lrrk2-induced neurodegeneration.
Parkinson Disease
Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb.
Parkinson Disease
Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling.
Parkinson Disease
Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
Parkinson Disease
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
Parkinson Disease
Dyskinesias in patients with Parkinson's disease: Effect of the leucine-rich repeat kinase 2 (LRRK2) G2019S mutation.
Parkinson Disease
Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans.
Parkinson Disease
Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.
Parkinson Disease
Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.
Parkinson Disease
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition.
Parkinson Disease
Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration.
Parkinson Disease
Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson's Disease Patients.
Parkinson Disease
Effect of dual-task interference on the hand flexibility of patients with Parkinson's disease carrying the leucine-rich repeat kinase 2 gene mutation.
Parkinson Disease
Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.
Parkinson Disease
Effect of LRRK2 G2385R Variant on Subthalamic Deep Brain Stimulation Efficacy in Parkinson's Disease in a Han Chinese Population.
Parkinson Disease
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
Parkinson Disease
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.
Parkinson Disease
Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission.
Parkinson Disease
Efficient allele-specific targeting of LRRK2 R1441 mutations mediated by RNAi.
Parkinson Disease
Efficient Estimation of Nonparametric Genetic Risk Function with Censored Data.
Parkinson Disease
Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair.
Parkinson Disease
Elevated levels of cerebrospinal fluid ?-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers.
Parkinson Disease
Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers.
Parkinson Disease
Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.
Parkinson Disease
Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation.
Parkinson Disease
Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons.
Parkinson Disease
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
Parkinson Disease
Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.
Parkinson Disease
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.
Parkinson Disease
Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls.
Parkinson Disease
ERKed by LRRK2: A cell biological perspective on hereditary and sporadic Parkinson's disease.
Parkinson Disease
Erratum: Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity.
Parkinson Disease
Erratum: LRRK2 Antisense Oligonucleotides Ameliorate ?-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.
Parkinson Disease
Erratum: Variable frequency of LRRK2 variants in the Latin American research consortium on the genetics of Parkinson's disease (LARGE-PD), a case of ancestry.
Parkinson Disease
Escaping Parkinson's disease: a neurologically healthy octogenarian with the LRRK2 G2019S mutation.
Parkinson Disease
Estimation of genetic risk function with covariates in the presence of missing genotypes.
Parkinson Disease
Etiology and pathophysiology of frontotemporal dementia, Parkinson disease and Alzheimer disease: lessons from genetic studies.
Parkinson Disease
Evaluating LRRK2 genetic variants with unclear pathogenicity.
Parkinson Disease
Evaluating the Role of SNCA, LRRK2, and GBA in Chinese Patients With Early-Onset Parkinson's Disease.
Parkinson Disease
Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease.
Parkinson Disease
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.
Parkinson Disease
Evaluation of the role of LRRK2 gene in Parkinson's disease in an East Indian cohort.
Parkinson Disease
Evidence for increased completed suicide in first-degree relatives of LRRK2 G2019S mutation Parkinson's disease.
Parkinson Disease
Evidence for prehistoric origins of the G2019S mutation in the North African Berber population.
Parkinson Disease
Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation.
Parkinson Disease
Exosome markers of LRRK2 kinase inhibition.
Parkinson Disease
Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells.
Parkinson Disease
Exploring the Effects of Genetic Variants on Clinical Profiles of Parkinson's Disease Assessed by the Unified Parkinson's Disease Rating Scale and the Hoehn-Yahr Stage.
Parkinson Disease
Exploring the functional impact of mutational drift in LRRK2 gene and identification of specific inhibitors for the treatment of Parkinson disease.
Parkinson Disease
Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.
Parkinson Disease
Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain.
Parkinson Disease
Expression of 14-3-3 transcript isoforms in response to ethanol exposure and their regulation by miRNAs.
Parkinson Disease
Expression of FasL and its interaction with Fas are mediated by c-Jun N-terminal kinase (JNK) pathway in 6-OHDA-induced rat model of Parkinson disease.
Parkinson Disease
Expression of leucine-rich-repeat-kinase 2 (LRRK2) during embryonic development.
Parkinson Disease
Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.
Parkinson Disease
Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2.
Parkinson Disease
Fall risk and gait in Parkinson's disease: the role of the LRRK2 G2019S mutation.
Parkinson Disease
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble ?-synuclein in neurons.
Parkinson Disease
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.
Parkinson Disease
Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.
Parkinson Disease
Fatigue correlates with LRRK2 G2385R variant in Chinese Parkinson's disease patients.
Parkinson Disease
Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.
Parkinson Disease
Fine-mapping of the non-coding variation driving the Caucasian LRRK2 GWAS signal in Parkinson's disease.
Parkinson Disease
Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus.
Parkinson Disease
First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein.
Parkinson Disease
First neuropathological description of a patient with Parkinson's disease and LRRK2 p.N1437H mutation.
Parkinson Disease
Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics.
Parkinson Disease
Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients.
Parkinson Disease
Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's Disease.
Parkinson Disease
Frequencies of LRRK2 variants in Thai patients with Parkinson's disease: evidence for an R1628P founder.
Parkinson Disease
Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease.
Parkinson Disease
Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease.
Parkinson Disease
Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.
Parkinson Disease
Frequency of the LRRK2 G2019S mutation in Italian patients affected by Parkinson's disease.
Parkinson Disease
Frequency of the LRRK2 G2019S mutation in late-onset sporadic patients with Parkinson's disease.
Parkinson Disease
Frequency of the LRRK2 G2019S mutation in siblings with Parkinson's disease.
Parkinson Disease
Frequency of the LRRK2 G2019S mutation in South African patients with Parkinson's disease.
Parkinson Disease
From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease.
Parkinson Disease
From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson's Disease: Lessons From LRRK2.
Parkinson Disease
Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond.
Parkinson Disease
Functional and behavioral consequences of Parkinson's disease-associated LRRK2-G2019S mutation.
Parkinson Disease
Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) Administration.
Parkinson Disease
Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.
Parkinson Disease
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
Parkinson Disease
Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance.
Parkinson Disease
Functional properties of LRRK2 mutations in Taiwanese Parkinson disease.
Parkinson Disease
G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort.
Parkinson Disease
G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system.
Parkinson Disease
G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.
Parkinson Disease
G2019S LRRK2 Increases Stress Susceptibility Through Inhibition of DAF-16 Nuclear Translocation in a 14-3-3 Associated-Manner in Caenorhabditis elegans.
Parkinson Disease
G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.
Parkinson Disease
G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies.
Parkinson Disease
G2019S LRRK2 mutation in familial and sporadic Parkinson's disease in Russia.
Parkinson Disease
G2019S LRRK2 mutation in French and North African families with Parkinson's disease.
Parkinson Disease
G2019S Mutation of the Leucine-Rich Repeat Kinase 2 Gene in a Cohort of Egyptian Patients with Parkinson's Disease.
Parkinson Disease
G2385R and I2020T Mutations Increase LRRK2 GTPase Activity.
Parkinson Disease
Gender differences in prevalence of LRRK2-associated Parkinson disease: A meta-analysis of observational studies.
Parkinson Disease
Gender differences in the risk of familial parkinsonism: beyond LRRK2?
Parkinson Disease
Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.
Parkinson Disease
Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease.
Parkinson Disease
Genealogical studies in LRRK2-associated Parkinson's disease in central Norway.
Parkinson Disease
Generation of 2 induced pluripotent stem cell lines derived from patients with Parkinson's disease carrying LRRK2 G2385R variant.
Parkinson Disease
Generation of a human induced pluripotent stem cell (iPSC) line carrying the Parkinson's disease linked LRRK2 variant S1647T.
Parkinson Disease
Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene.
Parkinson Disease
Generation of an induced pluripotent stem cell line (DANi-011A) from a Parkinson's disease patient with a LRRK2 p.G2019S mutation.
Parkinson Disease
Generation of fourteen isogenic cell lines for Parkinson's disease-associated leucine-rich repeat kinase (LRRK2).
Parkinson Disease
Generation of gene-corrected iPSC line, KIOMi002-A, from Parkinson's disease patient iPSC with LRRK2 G2019S mutation using BAC-based homologous recombination.
Parkinson Disease
Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson's disease carrying the I2020T mutation in LRRK2.
Parkinson Disease
Generation of induced pluripotent stem cells (IBMSi011-A) from a patient with Parkinson's disease carrying LRRK2 p.I1371V mutation.
Parkinson Disease
Generation of induced pluripotent stem cells (NIMHi001-A) from a Parkinson's disease patient of East Indian ethnicity carrying LRRK2 I1371V variant.
Parkinson Disease
Generation of induced pluripotent stem cells from a patient with Parkinson's disease carrying LRRK2 p.I2012T mutation.
Parkinson Disease
Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.
Parkinson Disease
Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage.
Parkinson Disease
Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: Importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.
Parkinson Disease
Genetic analysis of LRRK2 A419V variant in ethnic Chinese.
Parkinson Disease
Genetic analysis of LRRK2 functional domains in Brazilian patients with Parkinson's disease.
Parkinson Disease
Genetic analysis of LRRK2 in Parkinson's disease in Han Chinese population.
Parkinson Disease
Genetic analysis of LRRK2 mutations in patients with Parkinson disease.
Parkinson Disease
Genetic analysis of LRRK2 P755L variant in Caucasian patients with Parkinson's disease.
Parkinson Disease
Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutation.
Parkinson Disease
Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism.
Parkinson Disease
Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
Parkinson Disease
Genetic and Phenotypic Basis of Autosomal Dominant Parkinson's Disease in a Large Multi-Center Cohort.
Parkinson Disease
Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.
Parkinson Disease
Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease.
Parkinson Disease
Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression.
Parkinson Disease
Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study.
Parkinson Disease
Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival.
Parkinson Disease
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.
Parkinson Disease
Genetic factors influencing age at onset in LRRK2-linked Parkinson disease.
Parkinson Disease
Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
Parkinson Disease
Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.
Parkinson Disease
Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease.
Parkinson Disease
Genetic mouse models for understanding LRRK2 biology, pathology and pre-clinical application.
Parkinson Disease
Genetic risk factors in Finnish patients with Parkinson's disease.
Parkinson Disease
Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease.
Parkinson Disease
Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy.
Parkinson Disease
Genetic screening for two LRRK2 mutations in French patients with idiopathic Parkinson's disease.
Parkinson Disease
Genetic screening of the G2019S mutation of the LRRK2 gene in Southwest European, North African, and Sephardic Jewish subjects.
Parkinson Disease
Genetic Testing and Parkinson Disease: Assessment of Patient Knowledge, Attitudes, and Interest.
Parkinson Disease
Genetic testing of LRRK2 in Parkinson's disease: is there a clinical role?
Parkinson Disease
Genetic variants ofLRRK2 in Taiwanese Parkinson's disease.
Parkinson Disease
Genetic, structural, and molecular insights into the function of ras of complex proteins domains.
Parkinson Disease
Genetics of Parkinson's disease - a clinical perspective.
Parkinson Disease
Genetics of Parkinson's disease and parkinsonism.
Parkinson Disease
Genetics of Parkinson's disease.
Parkinson Disease
Genetics of Parkinson's disease: a review of SNCA and LRRK2.
Parkinson Disease
Genetics of Parkinson's disease: LRRK2 on the rise.
Parkinson Disease
Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila.
Parkinson Disease
Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease.
Parkinson Disease
Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.
Parkinson Disease
Genomewide linkage study of modifiers of LRRK2-related Parkinson's disease.
Parkinson Disease
Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset.
Parkinson Disease
Genotype-phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review.
Parkinson Disease
Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease.
Parkinson Disease
Ghrelin is neuroprotective in Parkinson's disease: molecular mechanisms of metabolic neuroprotection.
Parkinson Disease
Global distribution and reduced penetrance: Lrrk2 R1441C in an Irish Parkinson's disease kindred.
Parkinson Disease
Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations.
Parkinson Disease
Glucocerebrosidase mutations are not found in association with LRRK2 G2019S in subjects with parkinsonism.
Parkinson Disease
Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.
Parkinson Disease
Glycogen synthase kinase-3 as a key regulator of cognitive function.
Parkinson Disease
Glycogen synthase kinase-3 beta (GSK-3?) signaling: Implications for Parkinson's disease.
Parkinson Disease
Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease.
Parkinson Disease
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Parkinson Disease
Glycogen synthase kinase-3beta is associated with Parkinson's disease.
Parkinson Disease
Greater motor progression in patients with Parkinson disease who carry LRRK2 risk variants.
Parkinson Disease
GSK-3 as potential target for therapeutic intervention in cancer.
Parkinson Disease
GSK-3 in Neurodegenerative Diseases.
Parkinson Disease
GSK-3 Inhibitors: A new class of drugs for Alzheimer's Disease Treatment.
Parkinson Disease
GSK-3 mediates nuclear translocation of p62/SQSTM1 in MPTP-induced mouse model of Parkinson's disease.
Parkinson Disease
GSK-3? Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib.
Parkinson Disease
GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons.
Parkinson Disease
GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor.
Parkinson Disease
GSK3beta polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort.
Parkinson Disease
GST P1, a novel downstream regulator of LRRK2, G2019S-induced neuronal cell death.
Parkinson Disease
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
Parkinson Disease
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
Parkinson Disease
GTPase Activity and Neuronal Toxicity of Parkinson's Disease-Associated LRRK2 Is Regulated by ArfGAP1.
Parkinson Disease
GTPase activity plays a key role in the pathobiology of LRRK2.
Parkinson Disease
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
Parkinson Disease
GWAS risk factors in Parkinson's disease: LRRK2 coding variation and genetic interaction with PARK16.
Parkinson Disease
HDAC6 regulates mitochondrial transport in hippocampal neurons.
Parkinson Disease
Heat shock protein 90 modulates LRRK2 stability: potential implications for Parkinson's disease treatment.
Parkinson Disease
Hesperidin downregulates kinases lrrk2 and gsk3? in a 6-OHDA induced Parkinson's disease model.
Parkinson Disease
Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications.
Parkinson Disease
Heterozygous GBA D490V and ATP13a2 mutations do not exacerbate pathological ?-synuclein spread in the prodromal preformed fibrils model in young mice.
Parkinson Disease
Hierarchical Data-Driven Analysis of Clinical Symptoms Among Patients With Parkinson's Disease.
Parkinson Disease
High frequency and reduced penetrance of LRRK2 G2019S mutation among Parkinson's disease patients in Cantabria (Spain).
Parkinson Disease
High lithium levels in tobacco may account for reduced incidences of both Parkinson's disease and melanoma in smokers through enhanced ?-catenin-mediated activity.
Parkinson Disease
High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
Parkinson Disease
High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.
Parkinson Disease
High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal.
Parkinson Disease
Higher frequency of certain cancers in LRRK2 G2019S mutation carriers with Parkinson disease: a pooled analysis.
Parkinson Disease
Higher urate in LRRK2 mutation carriers resistant to Parkinson's disease.
Parkinson Disease
Higher Urine bis(Monoacylglycerol)Phosphate Levels in LRRK2 G2019S Mutation Carriers: Implications for Therapeutic Development.
Parkinson Disease
Highly Potent and Specific GSK-3beta Inhibitors That Block Tau Phosphorylation and Decrease alpha-Synuclein Protein Expression in a Cellular Model of Parkinson's Disease.
Parkinson Disease
Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment.
Parkinson Disease
How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease.
Parkinson Disease
Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.
Parkinson Disease
Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes.
Parkinson Disease
Hypercholinergic activity in LRRK2 Parkinson's disease.
Parkinson Disease
Hypothesis: Do miRNAs Targeting the Leucine-Rich Repeat Kinase 2 Gene (LRRK2) Influence Parkinson's Disease Susceptibility?
Parkinson Disease
I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.
Parkinson Disease
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3? signaling pathway.
Parkinson Disease
Identification & characterization of leucine-rich repeat kinase 2 & parkin RBR E3 ubiquitin protein ligase variants in patients with Parkinson's disease.
Parkinson Disease
Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.
Parkinson Disease
Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease.
Parkinson Disease
Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease.
Parkinson Disease
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.
Parkinson Disease
Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening.
Parkinson Disease
Identification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinson's disease.
Parkinson Disease
Identification of Bombyx mori 14-3-3 orthologs and the interactor Hsp60.
Parkinson Disease
Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls.
Parkinson Disease
Identification of four novel potentially Parkinson's disease associated LRRK2 variations among Iranian patients.
Parkinson Disease
Identification of LRRK2 missense variants in the accelerating medicines partnership Parkinson's disease cohort.
Parkinson Disease
Identification of novel variants in LRRK2 gene in patients with Parkinson's disease in Serbian population.
Parkinson Disease
Identification of peptides interfering with the LRRK2/PP1 interaction.
Parkinson Disease
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.
Parkinson Disease
Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2.
Parkinson Disease
Identification of Three Novel LRRK2 Mutations associated with Parkinson's Disease in a Calabrian Population.
Parkinson Disease
Impact of recent genetic findings in Parkinson's disease.
Parkinson Disease
Impact of Type II LRRK2 inhibitors on signalling and mitophagy.
Parkinson Disease
Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson's disease patients carrying the LRRK2 G2019S mutation.
Parkinson Disease
Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia.
Parkinson Disease
Impaired intracortical transmission in G2019S leucine rich-repeat kinase Parkinson patients.
Parkinson Disease
Improvements of Motor Performances in the Drosophila LRRK2 Loss-of-Function Model of Parkinson's Disease: Effects of Dialyzed Leucocyte Extracts from Human Serum.
Parkinson Disease
In silico and Wet Bench Interactomics Sheds Light on the Similitudes and Differences between Human ROCO Proteins.
Parkinson Disease
In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung.
Parkinson Disease
In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.
Parkinson Disease
In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets.
Parkinson Disease
In Vitro Modeling of Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S-Mediated Parkinson's Disease Pathology.
Parkinson Disease
Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity.
Parkinson Disease
Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins.
Parkinson Disease
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
Parkinson Disease
Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson's disease.
Parkinson Disease
Increased Oxidative Stress Markers in Cerebrospinal Fluid from Healthy Subjects with Parkinson's Disease-Associated LRRK2 Gene Mutations.
Parkinson Disease
Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers.
Parkinson Disease
Increased Striatal mRNA and Protein Levels of the Immunophilin FKBP-12 in Experimental Parkinson's Disease and Identification of FKBP-12-Binding Proteins.
Parkinson Disease
Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.
Parkinson Disease
Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond.
Parkinson Disease
Inflammatory bowel disease and Parkinson's disease: common pathophysiological links.
Parkinson Disease
Inflammatory Diseases Among Norwegian LRRK2 Mutation Carriers. A 15-Years Follow-Up of a Cohort.
Parkinson Disease
Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.
Parkinson Disease
Inhibiting thrombin improves motor function and decreases oxidative stress in the LRRK2 transgenic Drosophila melanogaster model of Parkinson's disease.
Parkinson Disease
Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation.
Parkinson Disease
Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity.
Parkinson Disease
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.
Parkinson Disease
Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization.
Parkinson Disease
Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker.
Parkinson Disease
Inhibitors of leucine-rich repeat kinase 2 (LRRK2): progress and promise for the treatment of Parkinson's disease.
Parkinson Disease
Inhibitors of LRRK2 as Treatment for Parkinson's Disease: Patent Highlight.
Parkinson Disease
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.
Parkinson Disease
Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice.
Parkinson Disease
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
Parkinson Disease
Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2.
Parkinson Disease
Integrating Gene Correction in the Reprogramming and Transdifferentiation Processes: A One-Step Strategy to Overcome Stem Cell-Based Gene Therapy Limitations.
Parkinson Disease
Interaction between SNCA, LRRK2 and GAK increases susceptibility to Parkinson's disease in a Chinese population.
Parkinson Disease
Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro.
Parkinson Disease
Interaction of LRRK2 and ?-Synuclein in Parkinson's Disease.
Parkinson Disease
Interaction of LRRK2 with kinase and GTPase signaling cascades.
Parkinson Disease
Interactions of CaMKII with dopamine D2 receptors: roles in levodopa-induced dyskinesia in 6-hydroxydopamine lesioned Parkinson's rats.
Parkinson Disease
Interest in genetic testing in Ashkenazi Jewish Parkinson's disease patients and their unaffected relatives.
Parkinson Disease
Interferon-? induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages.
Parkinson Disease
Interplay of LRRK2 with chaperone-mediated autophagy.
Parkinson Disease
Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.
Parkinson Disease
Intracellular Target-Specific Accretion of Cell Penetrating Peptides and Bioportides: Ultrastructural and Biological Correlates.
Parkinson Disease
Investigating convergent actions of genes linked to familial Parkinson's disease.
Parkinson Disease
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.
Parkinson Disease
Involvement of microRNA-135a-5p in the Protective Effects of Hydrogen Sulfide Against Parkinson's Disease.
Parkinson Disease
Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment.
Parkinson Disease
Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease.
Parkinson Disease
Is Inhibition of Kinase Activity the Only Therapeutic Strategy for LRRK2-associated Parkinson's Disease?
Parkinson Disease
Is the G2019S LRRK2 mutation common in all southern European populations?
Parkinson Disease
Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations.
Parkinson Disease
JNK inhibition as a potential strategy in treating Parkinson's disease.
Parkinson Disease
JNK-mediated activation of ATF2 contributes to dopaminergic neurodegeneration in the MPTP mouse model of Parkinson's disease.
Parkinson Disease
JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.
Parkinson Disease
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Parkinson Disease
Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes.
Parkinson Disease
Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery.
Parkinson Disease
Kinase drug discovery--what's next in the field?
Parkinson Disease
Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions.
Parkinson Disease
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.
Parkinson Disease
Kinases in synaptic development and neurological diseases.
Parkinson Disease
Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.
Parkinson Disease
Knockdown transgenic Lrrk Drosophila resists paraquat-induced locomotor impairment and neurodegeneration: A therapeutic strategy for Parkinson's disease.
Parkinson Disease
L'RRK de Triomphe: a solution for LRRK2 GTPase activity?
Parkinson Disease
L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner.
Parkinson Disease
Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease.
Parkinson Disease
Lack of association between the LRRK2 A419V variant and Asian Parkinson's disease.
Parkinson Disease
Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Parkinson Disease
Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease.
Parkinson Disease
Leucine rich repeat kinase 2 (LRRK2) GLY2019SER mutation is absent in a second cohort of Nigerian Africans with Parkinson disease.
Parkinson Disease
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents.
Parkinson Disease
Leucine Rich Repeat Kinase 2 and Innate Immunity.
Parkinson Disease
Leucine rich repeat kinase 2: a paradigm for pleiotropy.
Parkinson Disease
Leucine-Rich Repeat Kinase (LRRK2) Genetics and Parkinson's Disease.
Parkinson Disease
Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease.
Parkinson Disease
Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease.
Parkinson Disease
Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions.
Parkinson Disease
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Parkinson Disease
Leucine-rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes.
Parkinson Disease
Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity: Dependence on Dimerization.
Parkinson Disease
Leucine-rich repeat kinase 2 (LRRK2) mutations in a Swedish Parkinson cohort and a healthy nonagenarian.
Parkinson Disease
Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression.
Parkinson Disease
Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis.
Parkinson Disease
Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na(+)/K(+) ATPase Activity in Dendritic Cells.
Parkinson Disease
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
Parkinson Disease
Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease.
Parkinson Disease
Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway.
Parkinson Disease
Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease.
Parkinson Disease
Leucine-rich repeat kinase 2 and lysosomal dyshomeostasis in Parkinson disease.
Parkinson Disease
Leucine-rich repeat kinase 2 and Parkinson's disease.
Parkinson Disease
Leucine-rich repeat kinase 2 associates with lipid rafts.
Parkinson Disease
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Parkinson Disease
Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-?B Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells.
Parkinson Disease
Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
Parkinson Disease
Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.
Parkinson Disease
Leucine-rich repeat kinase 2 for beginners: six key questions.
Parkinson Disease
Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration.
Parkinson Disease
Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.
Parkinson Disease
Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation.
Parkinson Disease
Leucine-Rich Repeat Kinase 2 in Parkinson's Disease: Updated from Pathogenesis to Potential Therapeutic Target.
Parkinson Disease
Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway.
Parkinson Disease
Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells.
Parkinson Disease
Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 - 2011).
Parkinson Disease
Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).
Parkinson Disease
Leucine-rich repeat kinase 2 inhibitors: a review of recent patents (2011 - 2013).
Parkinson Disease
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Parkinson Disease
Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses.
Parkinson Disease
Leucine-Rich Repeat Kinase 2 Is Associated With Activation of the Paraventricular Nucleus of the Hypothalamus and Stress-Related Gastrointestinal Dysmotility.
Parkinson Disease
Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease.
Parkinson Disease
Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease.
Parkinson Disease
Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.
Parkinson Disease
Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells.
Parkinson Disease
Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity.
Parkinson Disease
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.
Parkinson Disease
Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?
Parkinson Disease
Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites.
Parkinson Disease
Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
Parkinson Disease
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Parkinson Disease
Leucine-rich repeat kinase 2-linked Parkinson's disease: clinical and molecular findings.
Parkinson Disease
Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cells.
Parkinson Disease
Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis.
Parkinson Disease
Leucine-rich repeat kinase 2: relevance to Parkinson's disease.
Parkinson Disease
Leucine-rich repeat kinase interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.
Parkinson Disease
Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration.
Parkinson Disease
Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype.
Parkinson Disease
Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3?.
Parkinson Disease
Levetiracetam treatment ameliorates LRRK2 pathological mutant phenotype.
Parkinson Disease
Lewis Acid-Facilitated Radiofluorination of MN3PU: A LRRK2 Radiotracer.
Parkinson Disease
Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease.
Parkinson Disease
LIPAD (LRRK2/Luebeck International Parkinson's Disease) Study Protocol: Deep Phenotyping of an International Genetic Cohort.
Parkinson Disease
LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson's disease progression.
Parkinson Disease
Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
Parkinson Disease
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.
Parkinson Disease
Long Non-coding RNA HOTAIR Promotes Parkinson's Disease Induced by MPTP Through up-regulating the Expression of LRRK2.
Parkinson Disease
Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease.
Parkinson Disease
Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs.
Parkinson Disease
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.
Parkinson Disease
Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Parkinson Disease
Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration.
Parkinson Disease
Low disease risk in relatives of north african lrrk2 Parkinson disease patients.
Parkinson Disease
Low frequency of common LRRK2 mutations in Mexican patients with Parkinson's disease.
Parkinson Disease
Low Levels of LRRK2 Gene Expression are Associated with LRRK2 SNPs and Contribute to Parkinson's Disease Progression.
Parkinson Disease
Lower cognitive performance in healthy G2019S LRRK2 mutation carriers.
Parkinson Disease
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.
Parkinson Disease
LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations.
Parkinson Disease
LRRK2 A419V variant is a risk factor for Parkinson's disease in Asian population.
Parkinson Disease
LRRK2 Ablation Attenuates ?lpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo.
Parkinson Disease
LRRK2 activation controls the repair of damaged endomembranes in macrophages.
Parkinson Disease
LRRK2 activation in idiopathic Parkinson's disease.
Parkinson Disease
LRRK2 activity does not dramatically alter ?-synuclein pathology in primary neurons.
Parkinson Disease
LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.
Parkinson Disease
Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.
Parkinson Disease
LRRK2 and Autophagy.
Parkinson Disease
Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation.
Parkinson Disease
LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease.
Parkinson Disease
LRRK2 and human disease: a complicated question or a question of complexes?
Parkinson Disease
LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
Parkinson Disease
LRRK2 and membrane trafficking: nexus of Parkinson's disease.
Parkinson Disease
LRRK2 and mitochondria: Recent advances and current views.
Parkinson Disease
LRRK2 and neurodegeneration.
Parkinson Disease
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.
Parkinson Disease
LRRK2 and Parkinson disease.
Parkinson Disease
LRRK2 and Parkinson's disease in Norway.
Parkinson Disease
LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models.
Parkinson Disease
LRRK2 and Rab GTPases.
Parkinson Disease
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
Parkinson Disease
LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.
Parkinson Disease
LRRK2 and the Endolysosomal System in Parkinson's Disease.
Parkinson Disease
LRRK2 and the Immune System.
Parkinson Disease
LRRK2 and the new era of Parkinson's disease research.
Parkinson Disease
LRRK2 Antisense Oligonucleotides Ameliorate ?-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.
Parkinson Disease
LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease.
Parkinson Disease
LRRK2 as a therapeutic target in Parkinson's disease.
Parkinson Disease
LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.
Parkinson Disease
LRRK2 at the Crossroad of Aging and Parkinson's Disease.
Parkinson Disease
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Parkinson Disease
LRRK2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.
Parkinson Disease
LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain.
Parkinson Disease
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same.
Parkinson Disease
LRRK2 contributes to monocyte dysregulation in Parkinson's disease.
Parkinson Disease
LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats.
Parkinson Disease
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.
Parkinson Disease
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.
Parkinson Disease
LRRK2 deficiency impacts ceramide metabolism in brain.
Parkinson Disease
LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.
Parkinson Disease
LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.
Parkinson Disease
LRRK2 dephosphorylation increases its ubiquitination.
Parkinson Disease
LRRK2 detection in human biofluids: potential use as a Parkinson's disease biomarker?
Parkinson Disease
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations.
Parkinson Disease
LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.
Parkinson Disease
LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.
Parkinson Disease
LRRK2 exon 41 mutations in sporadic Parkinson disease in Europeans.
Parkinson Disease
LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: A morphological and quantitative study.
Parkinson Disease
LRRK2 expression in normal and pathologic human brain and in human cell lines.
Parkinson Disease
LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1.
Parkinson Disease
LRRK2 expression is enriched in the striosomal compartment of mouse striatum.
Parkinson Disease
LRRK2 expression linked to dopamine-innervated areas.
Parkinson Disease
LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5.
Parkinson Disease
LRRK2 function on actin and microtubule dynamics in Parkinson disease.
Parkinson Disease
LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death.
Parkinson Disease
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
Parkinson Disease
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.
Parkinson Disease
LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity.
Parkinson Disease
LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.
Parkinson Disease
LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs.
Parkinson Disease
LRRK2 G2019S founder haplotype in the Chinese population.
Parkinson Disease
LRRK2 G2019S in Families with Parkinson Disease Who Originated from Europe and the Middle East: Evidence of Two Distinct Founding Events Beginning Two Millennia Ago.
Parkinson Disease
LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease.
Parkinson Disease
LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation.
Parkinson Disease
LRRK2 G2019S mutation and Parkinson's disease: A clinical, neuropsychological and neuropsychiatric study in a large Italian sample.
Parkinson Disease
LRRK2 G2019S mutation does not contribute to Parkinson's disease in South India.
Parkinson Disease
LRRK2 G2019S mutation in Parkinson's disease: A neuropsychological and neuropsychiatric study in a large Algerian cohort.
Parkinson Disease
LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.
Parkinson Disease
LRRK2 G2019S Mutation Inhibits Degradation of ?-Synuclein in an In Vitro Model of Parkinson's Disease.
Parkinson Disease
LRRK2 G2019S mutation: frequency and haplotype data in South African Parkinson's disease patients.
Parkinson Disease
LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson's Disease.
Parkinson Disease
LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease.
Parkinson Disease
LRRK2 G2019S Parkinson's disease with more benign phenotype than idiopathic.
Parkinson Disease
LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity.
Parkinson Disease
LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease.
Parkinson Disease
LRRK2 G2385R and LRRK2 R1628P increase risk of Parkinson's disease in a Han Chinese population from Southern Mainland China.
Parkinson Disease
LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population.
Parkinson Disease
Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.
Parkinson Disease
LRRK2 G2385R modulates age at onset in Parkinson's disease: A multi-center pooled analysis.
Parkinson Disease
LRRK2 G2385R variant carriers of female Parkinson's disease are more susceptible to motor fluctuation.
Parkinson Disease
LRRK2 G6055A mutation in Italian patients with familial or sporadic Parkinson's disease.
Parkinson Disease
LRRK2 gene G2019S mutation and SNPs [haplotypes] in subtypes of Parkinson's disease.
Parkinson Disease
LRRK2 gene in Parkinson disease.
Parkinson Disease
LRRK2 gene in Parkinson disease: mutation analysis and case control association study.
Parkinson Disease
LRRK2 gene variation and its contribution to Parkinson disease.
Parkinson Disease
LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson's disease compared to late-onset patients.
Parkinson Disease
LRRK2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease: a case-control study in Japan.
Parkinson Disease
LRRK2 Gly2385Arg variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
Parkinson Disease
LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.
Parkinson Disease
LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4.
Parkinson Disease
LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century.
Parkinson Disease
LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutation.
Parkinson Disease
LRRK2 I2020T mutation is associated with tau pathology.
Parkinson Disease
LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase.
Parkinson Disease
LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease.
Parkinson Disease
LRRK2 in Infection: Friend or Foe?
Parkinson Disease
LRRK2 in Parkinson disease: challenges of clinical trials.
Parkinson Disease
LRRK2 in Parkinson's disease - drawing the curtain of penetrance: a commentary.
Parkinson Disease
LRRK2 in Parkinson's disease and dementia with Lewy bodies.
Parkinson Disease
LRRK2 in Parkinson's disease: biochemical functions.
Parkinson Disease
LRRK2 in Parkinson's disease: building an understanding of disease etiology.
Parkinson Disease
LRRK2 in Parkinson's disease: function in cells and neurodegeneration.
Parkinson Disease
LRRK2 in Parkinson's disease: genetic and clinical studies from patients.
Parkinson Disease
LRRK2 in Parkinson's disease: in vivo models and approaches for understanding pathogenic roles.
Parkinson Disease
LRRK2 in Parkinson's disease: protein domains and functional insights.
Parkinson Disease
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.
Parkinson Disease
LRRK2 in Transcription and Translation Regulation: Relevance for Parkinson's Disease.
Parkinson Disease
LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance via Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes.
Parkinson Disease
LRRK2 inhibition attenuates microglial inflammatory responses.
Parkinson Disease
LRRK2 inhibition does not impart protection from ?-synuclein pathology and neuron death in non-transgenic mice.
Parkinson Disease
LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease.
Parkinson Disease
LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives.
Parkinson Disease
LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits.
Parkinson Disease
LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2.
Parkinson Disease
Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease.
Parkinson Disease
LRRK2 interactions with ?-synuclein in Parkinson's disease brains and in cell models.
Parkinson Disease
LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.
Parkinson Disease
LRRK2 interferes with aggresome formation for autophagic clearance.
Parkinson Disease
LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.
Parkinson Disease
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
Parkinson Disease
LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain.
Parkinson Disease
LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.
Parkinson Disease
LRRK2 is involved in the IFN-gamma response and host response to pathogens.
Parkinson Disease
LRRK2 is not a significant cause of Parkinson's disease in French-Canadians.
Parkinson Disease
LRRK2 is reduced in Parkinson's disease gut.
Parkinson Disease
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Parkinson Disease
LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status.
Parkinson Disease
LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons.
Parkinson Disease
LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation.
Parkinson Disease
LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients.
Parkinson Disease
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex.
Parkinson Disease
LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?
Parkinson Disease
LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons.
Parkinson Disease
LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells.
Parkinson Disease
LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation.
Parkinson Disease
LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction.
Parkinson Disease
LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation.
Parkinson Disease
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
Parkinson Disease
LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies.
Parkinson Disease
LRRK2 levels in immune cells are increased in Parkinson's disease.
Parkinson Disease
LRRK2 links genetic and sporadic Parkinson's disease.
Parkinson Disease
LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation.
Parkinson Disease
LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson's disease.
Parkinson Disease
LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication.
Parkinson Disease
LRRK2 mediates tubulation and vesicle sorting from lysosomes.
Parkinson Disease
LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.
Parkinson Disease
LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.
Parkinson Disease
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.
Parkinson Disease
Lrrk2 modulation of Wnt signaling during zebrafish development.
Parkinson Disease
LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis.
Parkinson Disease
LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8.
Parkinson Disease
LRRK2 mutation in familial Parkinson's disease in a Taiwanese population: clinical, PET, and functional studies.
Parkinson Disease
LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson's Disease Cohort from Kazakhstan.
Parkinson Disease
LRRK2 mutations and Parkinson's disease in Sardinia--A Mediterranean genetic isolate.
Parkinson Disease
LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease.
Parkinson Disease
LRRK2 mutations are a common cause of Parkinson's disease in Spain.
Parkinson Disease
LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.
Parkinson Disease
LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10.
Parkinson Disease
LRRK2 mutations in a clinic-based cohort of Parkinson's disease.
Parkinson Disease
LRRK2 mutations in Basque patients with Parkinson's disease - Authors' reply.
Parkinson Disease
LRRK2 mutations in Basque patients with Parkinson's disease.
Parkinson Disease
LRRK2 mutations in Parkinson disease.
Parkinson Disease
LRRK2 mutations in Parkinson disease; a sex effect or lack thereof? A meta-analysis.
Parkinson Disease
LRRK2 mutations in Parkinson's disease patients from Central Europe: A case control study.
Parkinson Disease
LRRK2 mutations in Parkinson's disease: confirmation of a gender effect in the Italian population.
Parkinson Disease
LRRK2 mutations in patients with Parkinson's disease from Peru and Uruguay.
Parkinson Disease
Lrrk2 mutations in South America: A study of Chilean Parkinson's disease.
Parkinson Disease
LRRK2 Mutations in Spanish Patients With Parkinson Disease: Frequency, Clinical Features, and Incomplete Penetrance.
Parkinson Disease
LRRK2 N551K and R1398H variants are protective in Malays and Chinese in Malaysia: A case-control association study for Parkinson's disease.
Parkinson Disease
LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Parkinson Disease
LRRK2 p.G2019S mutation is not common among Alzheimer's disease patients in Brazil.
Parkinson Disease
LRRK2 p.M1646T is associated with glucocerebrosidase activity and with Parkinson's disease.
Parkinson Disease
Lrrk2 p.Q1111H substitution and Parkinson's disease in Latin America.
Parkinson Disease
LRRK2 P755L variant in sporadic Parkinson's disease.
Parkinson Disease
LRRK2 Parkinson disease mutations enhance its microtubule association.
Parkinson Disease
LRRK2 Parkinson's disease: from animal models to cellular mechanisms.
Parkinson Disease
LRRK2 pathobiology in Parkinson's disease - virtual inclusion.
Parkinson Disease
LRRK2 pathobiology in Parkinson's disease.
Parkinson Disease
Lrrk2 pathogenic substitutions in Parkinson's disease.
Parkinson Disease
LRRK2 Pathways Leading to Neurodegeneration.
Parkinson Disease
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications.
Parkinson Disease
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
Parkinson Disease
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.
Parkinson Disease
LRRK2 phosphorylates novel tau epitopes and promotes tauopathy.
Parkinson Disease
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
Parkinson Disease
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.
Parkinson Disease
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Parkinson Disease
LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.
Parkinson Disease
LRRK2 Phosphorylation, More Than an Epiphenomenon.
Parkinson Disease
LRRK2 Phosphorylation.
Parkinson Disease
LRRK2 Phosphorylation: Behind the Scenes.
Parkinson Disease
LRRK2 Pro755Leu variant in ethnic Chinese population with Parkinson's disease.
Parkinson Disease
LRRK2 Promotes Tau Accumulation, Aggregation and Release.
Parkinson Disease
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
Parkinson Disease
LRRK2 R1398H polymorphism is associated with decreased risk of Parkinson's disease in a Han Chinese population.
Parkinson Disease
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.
Parkinson Disease
LRRK2 R1441G in Spanish patients with Parkinson's disease.
Parkinson Disease
LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity.
Parkinson Disease
Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain.
Parkinson Disease
LRRK2 R1628P contributes to Parkinson's disease susceptibility in Chinese Han populations from mainland China.
Parkinson Disease
LRRK2 R1628P increases risk of Parkinson's disease: replication evidence.
Parkinson Disease
LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
Parkinson Disease
LRRK2 recruitment, activity, and function in organelles.
Parkinson Disease
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.
Parkinson Disease
LRRK2 regulates endoplasmic reticulum-mitochondrial tethering through the PERK-mediated ubiquitination pathway.
Parkinson Disease
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
Parkinson Disease
LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.
Parkinson Disease
LRRK2 regulates synaptic vesicle endocytosis.
Parkinson Disease
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.
Parkinson Disease
LRRK2 Regulates Voltage-Gated Calcium Channel Function.
Parkinson Disease
Lrrk2 S1647T and BDNF V66M interact with environmental factors to increase risk of Parkinson's disease.
Parkinson Disease
LRRK2 screening in a Canadian Parkinson's disease cohort.
Parkinson Disease
LRRK2 secretion in exosomes is regulated by 14-3-3.
Parkinson Disease
LRRK2 signaling pathways: the key to unlocking neurodegeneration?
Parkinson Disease
LRRK2 Targeting Strategies as Potential Treatment of Parkinson's Disease.
Parkinson Disease
LRRK2 transport is regulated by its novel interacting partner Rab32.
Parkinson Disease
LRRK2 variation and dementia with Lewy bodies.
Parkinson Disease
LRRK2 variation and Parkinson's disease in African Americans.
Parkinson Disease
LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis.
Parkinson Disease
LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model.
Parkinson Disease
LRRK2, GBA and SMPD1 Founder Mutations and Parkinson's Disease in Ashkenazi Jews.
Parkinson Disease
Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain.
Parkinson Disease
LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.
Parkinson Disease
LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients.
Parkinson Disease
LRRK2-Related Parkinson's Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis.
Parkinson Disease
LRRK2: a common pathway for parkinsonism, pathogenesis and prevention?
Parkinson Disease
LRRK2: An Emerging New Molecule in the Enteric Neuronal System That Quantitatively Regulates Neuronal Peptides and IgA in the Gut.
Parkinson Disease
LRRK2: an éminence grise of Wnt-mediated neurogenesis?
Parkinson Disease
LRRK2: bridging the gap between sporadic and hereditary Parkinson's disease.
Parkinson Disease
LRRK2: Cause, Risk, and Mechanism.
Parkinson Disease
LRRK2: from kinase to GTPase to microtubules and back.
Parkinson Disease
LRRK2: Understanding the role of common and rare variants in Parkinson's disease.
Parkinson Disease
MAP1B rescues LRRK2 mutant-mediated cytotoxicity.
Parkinson Disease
MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease.
Parkinson Disease
MAPT IVS1+124 C>G modifies risk of LRRK2 G2385R for Parkinson's disease in Chinese individuals.
Parkinson Disease
Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson's Disease Model Mice.
Parkinson Disease
Measurement of LRRK2 and Ser910/935 Phosphorylated LRRK2 in Peripheral Blood Mononuclear Cells from Idiopathic Parkinson's Disease Patients.
Parkinson Disease
Measuring the activity of leucine-rich repeat kinase 2: a kinase involved in Parkinson's disease.
Parkinson Disease
Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.
Parkinson Disease
Mechanisms of LRRK2-mediated neurodegeneration.
Parkinson Disease
Mechanisms of Mutant LRRK2 Neurodegeneration.
Parkinson Disease
Melatonin attenuates hLRRK2-induced long-term memory deficit in a Drosophila model of Parkinson's disease.
Parkinson Disease
Meta-analysis of human gene expression in response to Mycobacterium tuberculosis infection reveals potential therapeutic targets.
Parkinson Disease
Metabolic alterations in plasma from patients with familial and idiopathic Parkinson's disease.
Parkinson Disease
Metabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson's Disease: A Pilot Study.
Parkinson Disease
Metabolic syndrome does not influence the phenotype of LRRK2 and GBA related Parkinson's disease.
Parkinson Disease
Metabolomic profiling in LRRK2-related Parkinson's disease.
Parkinson Disease
Methylation of ?-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients.
Parkinson Disease
Microarray expression analysis in idiopathic and LRRK2-associated Parkinson's disease.
Parkinson Disease
MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.
Parkinson Disease
MicroRNA-599 regulates the development of Parkinson's disease through mediating LRRK2 expression.
Parkinson Disease
Microtubule destabilization is shared by genetic and idiopathic Parkinson's disease patient fibroblasts.
Parkinson Disease
Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells.
Parkinson Disease
miR-135b Plays a Neuroprotective Role by Targeting GSK3? in MPP(+)-Intoxicated SH-SY5Y Cells.
Parkinson Disease
miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson's Disease.
Parkinson Disease
Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants.
Parkinson Disease
Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts.
Parkinson Disease
Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson's disease.
Parkinson Disease
Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease.
Parkinson Disease
Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.
Parkinson Disease
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin.
Parkinson Disease
Mitochondrial Protein PINK1 Positively Regulates RLR Signaling.
Parkinson Disease
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.
Parkinson Disease
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
Parkinson Disease
Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents.
Parkinson Disease
Modelling the functional genomics of Parkinson's disease in Caenorhabditis elegans: LRRK2 and beyond.
Parkinson Disease
Models of LRRK2-Associated Parkinson's Disease.
Parkinson Disease
Molecular analyses of the LRRK2 gene in European and North-African autosomal dominant Parkinson's disease.
Parkinson Disease
Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.
Parkinson Disease
Molecular Insights and Functional Implication of LRRK2 Dimerization.
Parkinson Disease
Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach.
Parkinson Disease
Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations.
Parkinson Disease
Mood and cognition in leucine-rich repeat kinase 2 G2019S Parkinson's disease.
Parkinson Disease
Motor and non-motor features of Parkinson's disease in LRRK2 G2019S carriers versus matched controls.
Parkinson Disease
Motor and nonmotor heterogeneity of LRRK2-related and idiopathic Parkinson's disease.
Parkinson Disease
Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease.
Parkinson Disease
Motor phenotype of LRRK2-associated Parkinson's disease: a tunisian longitudinal study.
Parkinson Disease
Motor progression of Parkinson's disease with the leucine-rich repeat kinase 2 G2019S mutation.
Parkinson Disease
Mouse models for LRRK2 Parkinson's disease.
Parkinson Disease
Movement disorders rounds: A case of missing pathology in a patient with LRRK2 Parkinson's disease.
Parkinson Disease
Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease.
Parkinson Disease
Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.
Parkinson Disease
Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons.
Parkinson Disease
Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation.
Parkinson Disease
Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.
Parkinson Disease
Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration.
Parkinson Disease
Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo.
Parkinson Disease
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies.
Parkinson Disease
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
Parkinson Disease
Mutant of leucine-rich repeat kinase 2 is not associated with non-motor symptoms in Chinese Parkinson's disease patients.
Parkinson Disease
Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.
Parkinson Disease
Mutation analysis of patients with neurodegenerative disorders using NeuroX array.
Parkinson Disease
Mutations in LRRK2 as a cause of Parkinson's disease.
Parkinson Disease
Mutations in LRRK2 impair NF-?B pathway in iPSC-derived neurons.
Parkinson Disease
Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease.
Parkinson Disease
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.
Parkinson Disease
Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data.
Parkinson Disease
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.
Parkinson Disease
NAPE-specific phospholipase D regulates LRRK2 association with neuronal membranes.
Parkinson Disease
Negative screening for 12 rare LRRK2 pathogenic variants in a cohort of Nigerians with Parkinson's disease.
Parkinson Disease
Network abnormalities among non-manifesting Parkinson disease related LRRK2 mutation carriers.
Parkinson Disease
Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.
Parkinson Disease
Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation.
Parkinson Disease
Neurobiology: A pathogenic tug of war.
Parkinson Disease
Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation.
Parkinson Disease
Neurodegenerative phenotypes in an A53T ?-synuclein transgenic mouse model are independent of LRRK2.
Parkinson Disease
Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out.
Parkinson Disease
Neuronal death signaling pathways triggered by mutant LRRK2.
Parkinson Disease
Neuropathology of Parkinson's disease associated with the LRRK2 Ile1371Val mutation.
Parkinson Disease
Neuropathology of Parkinson's disease with the R1441G mutation in LRRK2.
Parkinson Disease
Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide.
Parkinson Disease
Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease.
Parkinson Disease
Neuropsychological performance in LRRK2 G2019S carriers with Parkinson's disease.
Parkinson Disease
New Light Shed on Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Inhibitors in Parkinson's Disease.
Parkinson Disease
New LRRK2 variants identified in Parkinson's disease.
Parkinson Disease
Nigral and striatal connectivity alterations in asymptomatic LRRK2 mutation carriers: A magnetic resonance imaging study.
Parkinson Disease
Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.
Parkinson Disease
No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese.
Parkinson Disease
No association of DNM3 with age of onset in Asian Parkinson's disease.
Parkinson Disease
No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts.
Parkinson Disease
Non-cell autonomous mechanism of Parkinson's disease pathology caused by G2019S LRRK2 mutation in Ashkenazi Jewish patient: Single cell analysis.
Parkinson Disease
Non-motor symptoms in Chinese Parkinson's disease patients with and without LRRK2 G2385R and R1628P variants.
Parkinson Disease
Nonmotor symptoms in LRRK2 G2019S associated Parkinson's disease.
Parkinson Disease
Nonsteroidal Anti-Inflammatory Use and LRRK2 Parkinson's Disease Penetrance.
Parkinson Disease
Novel Cell-Based Assay for Identification of LRRK2 Inhibitors Using Its Aberrant Regulation of a Pluripotency Gene.
Parkinson Disease
Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.
Parkinson Disease
Novel gene (TMEM230) linked to Parkinson's disease.
Parkinson Disease
Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease.
Parkinson Disease
Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.
Parkinson Disease
Novel N-Heteroaryl Indazole Derivatives as LRRK2 Inhibitors for Treating Parkinson's Disease.
Parkinson Disease
Novel N-Heteroaryl Quinazolin-2-amine Derivatives as LRRK2 Inhibitors for Treating Parkinson's Disease.
Parkinson Disease
Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease.
Parkinson Disease
Novel recruitment strategy to enrich for LRRK2 mutation carriers.
Parkinson Disease
Novel Variants in LRRK2 and GBA Identified in Latino Parkinson Disease Cohort Enriched for Caribbean Origin.
Parkinson Disease
Nrf2 mitigates LRRK2- and ?-synuclein-induced neurodegeneration by modulating proteostasis.
Parkinson Disease
Nucks1 gene polymorphism rs823114 is associated with the positive symptoms and neurocognitive function of patients with schizophrenia in parts of southern China.
Parkinson Disease
Number and brightness analysis of LRRK2 oligomerization in live cells.
Parkinson Disease
Occurrence of Crohn's disease with Parkinson's disease.
Parkinson Disease
Olfaction and imaging biomarkers in premotor LRRK2 G2019S-associated Parkinson disease.
Parkinson Disease
Olfaction in LRRK2 Linked Parkinson's Disease: Is It Different from Idiopathic Parkinson's Disease?
Parkinson Disease
Olfactory deficits and cardiac (123) I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations.
Parkinson Disease
Olfactory Dysfunction in Parkinson's Disease Patients with the LRRK2 G2385R Variant.
Parkinson Disease
Olfactory dysfunction in sporadic Parkinson's Disease and LRRK2 carriers.
Parkinson Disease
Olfactory heterogeneity in LRRK2 related Parkinsonism.
Parkinson Disease
Oligomerization of Lrrk controls actin severing and ?-synuclein neurotoxicity in vivo.
Parkinson Disease
Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation.
Parkinson Disease
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors.
Parkinson Disease
Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice.
Parkinson Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Parkinson Disease
Outcomes of genetic test disclosure and genetic counseling in a large Parkinson's disease research study.
Parkinson Disease
Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and ?-Synuclein Pathology.
Parkinson Disease
PAK6 Phosphorylates 14-3-3? to Regulate Steady State Phosphorylation of LRRK2.
Parkinson Disease
Parkin Exon Rearrangements and Sequence Variants in LRRK2 Mutations Carriers: Analysis on a Possible Modifier Effect on LRRK2 Penetrance.
Parkinson Disease
Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-? hydroxysteroid dehydrogenase type 10.
Parkinson Disease
Parkin suppresses c-Jun N-terminal kinase-induced cell death via transcriptional regulation in Drosophila.
Parkinson Disease
Parkinson disease and leucine-rich repeat kinase 2 gene mutation: abridged secondary publication.
Parkinson Disease
Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations.
Parkinson Disease
Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder.
Parkinson Disease
Parkinson disease, cancer, and LRRK2: Causation or association?
Parkinson Disease
Parkinson disease, LRRK2 and the endocytic-autophagic pathway.
Parkinson Disease
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Parkinson Disease
Parkinson disease: LRRK2 variants linked to PD and Crohn's disease.
Parkinson Disease
Parkinson's disease and immune system: is the culprit LRRKing in the periphery?
Parkinson Disease
Parkinson's disease and low frequency alleles found together throughout LRRK2.
Parkinson Disease
Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics.
Parkinson Disease
Parkinson's disease and mitophagy: an emerging role for LRRK2.
Parkinson Disease
Parkinson's disease in the Western Pacific Region.
Parkinson Disease
Parkinson's disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration.
Parkinson Disease
Parkinson's disease-associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages.
Parkinson Disease
Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology.
Parkinson Disease
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.
Parkinson Disease
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.
Parkinson Disease
Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.
Parkinson Disease
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Parkinson Disease
Parkinson's Disease-Linked LRRK2-G2019S Mutation Alters Synaptic Plasticity and Promotes Resilience to Chronic Social Stress in Young Adulthood.
Parkinson Disease
Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.
Parkinson Disease
Parkinson's Disease: A Traffic Jam?
Parkinson Disease
Parkinson's disease: leucine-rich repeat kinase 2 and autophagy, intimate enemies.
Parkinson Disease
Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus.
Parkinson Disease
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
Parkinson Disease
Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity.
Parkinson Disease
Parkinsonian phenotype in Machado-Joseph disease (MJD/SCA3): a two-case report.
Parkinson Disease
Pathogenic Feed-Forward Mechanisms in Alzheimer's and Parkinson's Disease Converge on GSK-3.
Parkinson Disease
Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.
Parkinson Disease
Pathogenic LRRK2 mutations in nuclear ageing-A new organelle to study in Parkinson's disease.
Parkinson Disease
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.
Parkinson Disease
Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
Parkinson Disease
Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.
Parkinson Disease
Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of ?-catenin signaling.
Parkinson Disease
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Parkinson Disease
Pathogenicity of LRRK2 P755L variant in Parkinson's disease.
Parkinson Disease
Pathogenicity of the Lrrk2 R1514Q substitution in Parkinson's disease.
Parkinson Disease
Pathological Functions of LRRK2 in Parkinson's Disease.
Parkinson Disease
Pathological roles of ?-synuclein in neurological disorders.
Parkinson Disease
Pathophysiological heterogeneity in Parkinson's disease: Neurophysiological insights from LRRK2 mutations.
Parkinson Disease
Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations.
Parkinson Disease
Patient-control association study of the Leucine-Rich repeat kinase 2 (LRRK2) gene in South African Parkinson's disease patients.
Parkinson Disease
Patterns of Linkage Disequilibrium of LRRK2 across Different Races: Implications for Genetic Association Studies.
Parkinson Disease
Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain).
Parkinson Disease
Penetrance of LRRK2 mutations in familial Parkinson disease.
Parkinson Disease
Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score.
Parkinson Disease
Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants.
Parkinson Disease
PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.
Parkinson Disease
Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics.
Parkinson Disease
Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation.
Parkinson Disease
Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice.
Parkinson Disease
Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers.
Parkinson Disease
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.
Parkinson Disease
Phenotypical Differences in Neuronal Cultures Derived via Reprogramming the Fibroblasts from Patients Carrying Mutations in Parkinsonian Genes LRRK2 and PARK2.
Parkinson Disease
Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.
Parkinson Disease
Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.
Parkinson Disease
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
Parkinson Disease
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Parkinson Disease
Phosphoregulation on mitochondria: Integration of cell and organelle responses.
Parkinson Disease
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.
Parkinson Disease
Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
Parkinson Disease
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
Parkinson Disease
Phosphorylation of LRRK2 by casein kinase 1? regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Parkinson Disease
Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition.
Parkinson Disease
Phosphorylation-Dependent 14-3-3 Binding to LRRK2 Is Impaired by Common Mutations of Familial Parkinson's Disease.
Parkinson Disease
Physiological and pathological functions of LRRK2: implications from substrate proteins.
Parkinson Disease
Physiological and pathological roles of LRRK2 in the nuclear envelope integrity.
Parkinson Disease
PINK1 activation-turning on a promiscuous kinase.
Parkinson Disease
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
Parkinson Disease
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.
Parkinson Disease
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.
Parkinson Disease
PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1.
Parkinson Disease
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
Parkinson Disease
PINK1 is degraded through the N-end rule pathway.
Parkinson Disease
PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.
Parkinson Disease
PINK1 regulates mitochondrial trafficking in dendrites of cortical neurons through mitochondrial PKA.
Parkinson Disease
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.
Parkinson Disease
PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila.
Parkinson Disease
PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.
Parkinson Disease
Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson's disease.
Parkinson Disease
Population-specific frequencies for LRRK2 susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO-PD) consortium.
Parkinson Disease
Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease.
Parkinson Disease
Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors.
Parkinson Disease
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.
Parkinson Disease
Precision medicine in Parkinson's disease patients with LRRK2 and GBA risk variants - Let's get even more personal.
Parkinson Disease
Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.
Parkinson Disease
Prediction of the Repeat Domain Structures and Impact of Parkinsonism-Associated Variations on Structure and Function of all Functional Domains of Leucine-Rich Repeat Kinase 2 (LRRK2).
Parkinson Disease
Presynaptic dysfunction in Parkinson's disease: a focus on LRRK2.
Parkinson Disease
Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease.
Parkinson Disease
Prevalence and clinical features of LRRK2 mutations in patients with Parkinson's disease in southern Spain.
Parkinson Disease
Prevalence of cancer in Parkinson's disease related to R1441G and G2019S mutations in LRRK2.
Parkinson Disease
Prevalence of pre-diagnostic symptoms did not differ between LRRK2-related, GBA-related and idiopathic patients with Parkinson's disease.
Parkinson Disease
Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort.
Parkinson Disease
Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.
Parkinson Disease
Progress in familial Parkinson's disease.
Parkinson Disease
Progress in LRRK2-Associated Parkinson's Disease Animal Models.
Parkinson Disease
Progression and treatment of a series of patients with advanced LRRK2-associated Parkinson's disease.
Parkinson Disease
Progression in the LRRK2-Asssociated Parkinson Disease Population.
Parkinson Disease
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.
Parkinson Disease
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.
Parkinson Disease
Prospective clinical and DaT-SPECT imaging in premotor LRRK2 G2019S-associated Parkinson disease.
Parkinson Disease
Protective and toxic roles of dopamine in Parkinson's disease.
Parkinson Disease
Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.
Parkinson Disease
Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function.
Parkinson Disease
Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation.
Parkinson Disease
Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2.
Parkinson Disease
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Parkinson Disease
Psychological distress and lack of PINK1 promote bioenergetics alterations in peripheral blood mononuclear cells.
Parkinson Disease
QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease.
Parkinson Disease
Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis.
Parkinson Disease
Quantitative haplotyping of PCR products by nonsynchronous pyrosequencing with di-base addition.
Parkinson Disease
Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients.
Parkinson Disease
Quantitative Proteomic Analysis of Primitive Neural Stem Cells from LRRK2 G2019S-Associated Parkinson's Disease Patient-Derived iPSCs.
Parkinson Disease
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.
Parkinson Disease
R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.
Parkinson Disease
R1514Q substitution in Lrrk2 is not a pathogenic Parkinson's disease mutation.
Parkinson Disease
Rab GTPases as Physiological Substrates of LRRK2 Kinase.
Parkinson Disease
Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag.
Parkinson Disease
Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease.
Parkinson Disease
Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking.
Parkinson Disease
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.
Parkinson Disease
RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A.
Parkinson Disease
Radiosynthesis and evaluation of 4-(6-[18F]Fluoro-4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)morpholine as a novel radiotracer candidate targeting leucine-rich repeat kinase 2.
Parkinson Disease
Radiosynthesis and in Vivo Evaluation of [(11)C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain.
Parkinson Disease
Rare and common LRRK2 exonic variants in Parkinson's disease.
Parkinson Disease
Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form.
Parkinson Disease
Re: LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8.
Parkinson Disease
Re: The G2019S LRRK2 mutation is uncommon amongst Greek patients with familial Parkinson's disease.
Parkinson Disease
Reading the phosphorylation code: binding of the 14-3-3 protein to multivalent client phosphoproteins.
Parkinson Disease
Recent advances in Parkinson's disease genetics.
Parkinson Disease
Recent Developments in LRRK2-Targeted Therapy for Parkinson's Disease.
Parkinson Disease
Recurrent LRRK2 (Park8) mutations in early-onset Parkinson's disease.
Parkinson Disease
Redox Proteomics Analyses of the Influence of Co-expression of Wild Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease.
Parkinson Disease
Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers.
Parkinson Disease
Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2.
Parkinson Disease
Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNF?-mediated apoptosis.
Parkinson Disease
Regulation of autophagy by LRRK2 in Caenorhabditis elegans.
Parkinson Disease
Regulation of LRRK2 expression points to a functional role in human monocyte maturation.
Parkinson Disease
Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP.
Parkinson Disease
Regulation of LRRK2: insights from structural and biochemical analysis.
Parkinson Disease
Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.
Parkinson Disease
Regulation of Physiologic Actions of LRRK2: Focus on Autophagy.
Parkinson Disease
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention.
Parkinson Disease
Relationship between LRRK2 R1628P polymorphism and Parkinson's disease in Asian populations.
Parkinson Disease
Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population.
Parkinson Disease
Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers.
Parkinson Disease
Reprogramming of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient with a R1628P variant in the LRRK2 gene.
Parkinson Disease
Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson's Disease.
Parkinson Disease
RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player.
Parkinson Disease
Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.
Parkinson Disease
ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease.
Parkinson Disease
ROCO kinase activity is controlled by internal GTPase function.
Parkinson Disease
Roco Proteins and the Parkinson's Disease-Associated LRRK2.
Parkinson Disease
Roco Proteins: GTPases with a Baroque Structure and Mechanism.
Parkinson Disease
Role of glycogen synthase kinase-3 in l-DOPA-induced neurotoxicity.
Parkinson Disease
Role of LRRK2 and SNCA in autosomal dominant Parkinson's disease in Turkey.
Parkinson Disease
Role of LRRK2 in the regulation of dopamine receptor trafficking.
Parkinson Disease
Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.
Parkinson Disease
Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation.
Parkinson Disease
Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning.
Parkinson Disease
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
Parkinson Disease
Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 ? Inhibitors.
Parkinson Disease
Screening for chemical modulators for LRRK2.
Parkinson Disease
Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families.
Parkinson Disease
Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant.
Parkinson Disease
Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants.
Parkinson Disease
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Parkinson Disease
Screening LRRK2 gene mutations in patients with Parkinson's disease in Ghana.
Parkinson Disease
Screening of LRRK2 interactants by yeast 2-hybrid analysis.
Parkinson Disease
Selective Inhibitors of G2019S-LRRK2 Kinase Activity.
Parkinson Disease
Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.
Parkinson Disease
Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease.
Parkinson Disease
Sequence conservation between porcine and human LRRK2.
Parkinson Disease
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Parkinson Disease
Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease.
Parkinson Disease
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Parkinson Disease
Serial DaT-SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8 years' follow-up.
Parkinson Disease
Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
Parkinson Disease
Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies.
Parkinson Disease
Serum Uric Acid in LRRK2 Related Parkinson's Disease: Longitudinal Data from the PPMI Study.
Parkinson Disease
Sex differences in LRRK2 G2019S and idiopathic Parkinson's Disease.
Parkinson Disease
Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease.
Parkinson Disease
Short- and long-term effects of LRRK2 on axon and dendrite growth.
Parkinson Disease
Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.
Parkinson Disease
Silent Information Regulator 2 (Sir2) and Forkhead box O (FOXO) Complement Mitochondrial Dysfunction and Dopaminergic Neuron Loss in Drosophila Pten-induced kinase 1 (PINK1) Null Mutant.
Parkinson Disease
Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease.
Parkinson Disease
Single Inflammatory Trigger Leads to Neuroinflammation in LRRK2 Rodent Model without Degeneration of Dopaminergic Neurons.
Parkinson Disease
Sleep aspects on video-polysomnography in LRRK2 mutation carriers.
Parkinson Disease
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers.
Parkinson Disease
Small Molecule Kinase Inhibitors for LRRK2 and Their Application to Parkinson's Disease Models.
Parkinson Disease
Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment.
Parkinson Disease
Small-Molecule Inhibitors of LRRK2.
Parkinson Disease
SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease.
Parkinson Disease
SNCA but not DNM3 and GAK modifies age at onset of LRRK2-related Parkinson's disease in Chinese population.
Parkinson Disease
SNCA, LRRK2, MAPT polymorphisms and Parkinson's disease in Russia.
Parkinson Disease
Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.
Parkinson Disease
SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease.
Parkinson Disease
STK39, overexpressed in osteosarcoma, regulates osteosarcoma cell invasion and proliferation.
Parkinson Disease
Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation.
Parkinson Disease
Striatal leucine-rich repeat kinase 2 mRNA is increased in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned common marmosets (Callithrix jacchus) with L-3, 4-dihydroxyphenylalanine methyl ester-induced dyskinesia.
Parkinson Disease
Structural analysis of the full-length human LRRK2.
Parkinson Disease
Structural and functional in silico analysis of LRRK2 missense substitutions.
Parkinson Disease
Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2.
Parkinson Disease
Structural binding site comparisons reveal Crizotinib as a novel LRRK2 inhibitor.
Parkinson Disease
Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.
Parkinson Disease
Structural Characterization of LRRK2 Inhibitors.
Parkinson Disease
Structural interface between LRRK2 and 14-3-3 protein.
Parkinson Disease
Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.
Parkinson Disease
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.
Parkinson Disease
Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease.
Parkinson Disease
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Parkinson Disease
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration.
Parkinson Disease
Substantia nigra hyperechogenicity in Parkinson disease patients with leucine-rich repeat kinase 2 variants in the Chinese Han population.
Parkinson Disease
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
Parkinson Disease
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide.
Parkinson Disease
Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis.
Parkinson Disease
Survival rates among Parkinson's disease patients who carry mutations in the LRRK2 and GBA genes.
Parkinson Disease
Synthesis and biological evaluation of novel 2 (4`-hydroxynaphthyl) chromen-4-one as a CK2 inhibitor.
Parkinson Disease
Synthesis and In Vitro and In Vivo Evaluation of [(3)H]LRRK2-IN-1 as a Novel Radioligand for LRRK2.
Parkinson Disease
Synthesis of [(11)C]HG-10-102-01 as a new potential PET agent for imaging of LRRK2 enzyme in Parkinson's disease.
Parkinson Disease
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
Parkinson Disease
Systematic Review and UK-Based Study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.
Parkinson Disease
Targeting disease through novel pathways of apoptosis and autophagy.
Parkinson Disease
Targeting kinases in Parkinson's disease: A mechanism shared by LRRK2, neurotrophins, exenatide, urate, nilotinib and lithium.
Parkinson Disease
Targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of Parkinson's disease.
Parkinson Disease
Targeting leucine-rich repeat kinase 2 in Parkinson's disease.
Parkinson Disease
Targeting LRRK2 in Parkinson's disease: an update on recent developments.
Parkinson Disease
Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders.
Parkinson Disease
Test for LRRK2 mutations in patients with Parkinson's disease.
Parkinson Disease
Testing association between LRRK2 and Parkinson's disease and investigating linkage disequilibrium.
Parkinson Disease
The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions.
Parkinson Disease
The association between glycogen synthase kinase 3 beta polymorphisms and Parkinson's disease susceptibility: a meta-analysis.
Parkinson Disease
The Association between LRRK2 G2385R and Phenotype of Parkinson's Disease in Asian Population: A Meta-Analysis of Comparative Studies.
Parkinson Disease
The association between the LRRK2 G2385R variant and the risk of Parkinson's disease: a meta-analysis based on 23 case-control studies.
Parkinson Disease
The association between the LRRK2 R1628P variant and the risk of Parkinson's disease in Asian: a meta-analysis.
Parkinson Disease
The biology and pathobiology of LRRK2: implications for Parkinson's disease.
Parkinson Disease
The biology and pathology of the familial Parkinson's disease protein LRRK2.
Parkinson Disease
The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo.
Parkinson Disease
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T ?-Synuclein Toxicity in Dopaminergic Neurons In Vivo.
Parkinson Disease
The cannabinoid agonist WIN55212-2 decreases L-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated rats.
Parkinson Disease
The Cell Biology of LRRK2 in Parkinson's Disease.
Parkinson Disease
The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.
Parkinson Disease
The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease.
Parkinson Disease
The contribution of Niemann-Pick SMPD1 mutations to Parkinson disease in Ashkenazi Jews.
Parkinson Disease
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.
Parkinson Disease
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.
Parkinson Disease
The development of inhibitors of leucine-rich repeat kinase 2 (LRRK2) as a therapeutic strategy for Parkinson's disease: the current state of play.
Parkinson Disease
The Discovery of LRRK2 Mutations as a Cause of Parkinson's Disease.
Parkinson Disease
The discovery of LRRK2 p.R1441S, a novel mutation for Parkinson's disease, adds to the complexity of a mutational hotspot.
Parkinson Disease
The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFG? motif in the kinase domain.
Parkinson Disease
The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study.
Parkinson Disease
The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System.
Parkinson Disease
The familial Parkinsonism gene LRRK2 regulates neurite process morphology.
Parkinson Disease
The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.
Parkinson Disease
The G2019S LRRK2 mutation in Brazilian patients with Parkinson's disease: phenotype in monozygotic twins.
Parkinson Disease
The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.
Parkinson Disease
The G2019S LRRK2 Mutation is Rare in Korean Patients with Parkinson's Disease and Multiple System Atrophy.
Parkinson Disease
The G2019S LRRK2 mutation is rare in Korean patients with Parkinson's disease.
Parkinson Disease
The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease.
Parkinson Disease
The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients.
Parkinson Disease
The G2019S LRRK2 mutation: another morbid burden for Ashkenazi Jews may provide new insights on sporadic Parkinson's disease.
Parkinson Disease
The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.
Parkinson Disease
The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.
Parkinson Disease
The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.
Parkinson Disease
The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation.
Parkinson Disease
The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.
Parkinson Disease
The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism.
Parkinson Disease
The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study.
Parkinson Disease
The heterozygous R1441C mutation of leucine-rich repeat kinase 2 gene in a Chinese patient with Parkinson disease: A five-year follow-up and literatures review.
Parkinson Disease
The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities.
Parkinson Disease
The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling.
Parkinson Disease
The impact of murine LRRK2 G2019S transgene overexpression on acute responses to inflammatory challenge.
Parkinson Disease
The importance of LRRK2 mutations in Parkinson disease.
Parkinson Disease
The In Situ Structure of Parkinson's Disease-Linked LRRK2.
Parkinson Disease
The long noncoding RNA HOTAIR promotes Parkinson's disease by upregulating LRRK2 expression.
Parkinson Disease
The LRRK2 Arg1628Pro variant is a risk factor for Parkinson's disease in the Chinese population.
Parkinson Disease
The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews.
Parkinson Disease
The LRRK2 G2019S mutation in a series of Argentinean patients with Parkinson's disease: Clinical and demographic characteristics.
Parkinson Disease
The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease: is there a gender effect?
Parkinson Disease
The LRRK2 G2019S mutation is associated with Parkinson disease and concomitant non-skin cancers.
Parkinson Disease
The LRRK2 G2019S mutation status does not affect the outcome of subthalamic stimulation in patients with Parkinson's disease.
Parkinson Disease
The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.
Parkinson Disease
The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population.
Parkinson Disease
The LRRK2 gene in Parkinson's disease: mutation screening in patients from Germany.
Parkinson Disease
The LRRK2 gene is mutated in a Chinese autosomal-dominant Parkinson's disease family.
Parkinson Disease
The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence.
Parkinson Disease
The LRRK2 I2012T, G2019S and I2020T mutations are not common in patients with essential tremor.
Parkinson Disease
The LRRK2 I2012T, G2019S, and I2020T mutations are rare in Taiwanese patients with sporadic Parkinson's disease.
Parkinson Disease
The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.
Parkinson Disease
The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant.
Parkinson Disease
The LRRK2 R1441C mutation is more frequent than G2019S in Parkinson's disease patients from Southern Italy.
Parkinson Disease
The LRRK2 signalling system.
Parkinson Disease
The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.
Parkinson Disease
The LRRK2-RAB axis in regulation of vesicle trafficking and ?-synuclein propagation.
Parkinson Disease
The Michael J. Fox Foundation's Strategies for Accelerating Translation of LRRK2 into Therapies for Parkinson Disease.
Parkinson Disease
The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.
Parkinson Disease
The mouse/human cross-species heterodimer of leucine-rich repeat kinase 2: Possible significance in the transgenic model mouse of Parkinson's disease.
Parkinson Disease
The Neurobiology of LRRK2 and its Role in the Pathogenesis of Parkinson's Disease.
Parkinson Disease
The neuropathology of genetic Parkinson's disease.
Parkinson Disease
The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila.
Parkinson Disease
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.
Parkinson Disease
The Parkinson disease gene LRRK2: evolutionary and structural insights.
Parkinson Disease
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
Parkinson Disease
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.
Parkinson Disease
The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro.
Parkinson Disease
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.
Parkinson Disease
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
Parkinson Disease
The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.
Parkinson Disease
The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
Parkinson Disease
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Parkinson Disease
The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells.
Parkinson Disease
The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2.
Parkinson Disease
The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.
Parkinson Disease
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.
Parkinson Disease
The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4.
Parkinson Disease
The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.
Parkinson Disease
The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson's disease.
Parkinson Disease
The prevalence of the G2019S and R1441C/G/H mutations in LRRK2 in German patients with Parkinson's disease.
Parkinson Disease
The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.
Parkinson Disease
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
Parkinson Disease
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules.
Parkinson Disease
The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties.
Parkinson Disease
The role of c-Jun N-terminal kinase (JNK) in Parkinson's disease.
Parkinson Disease
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.
Parkinson Disease
The role of LRRK2 in cytoskeletal dynamics.
Parkinson Disease
The Role of LRRK2 in Neurodegeneration of Parkinson Disease.
Parkinson Disease
The Role of LRRK2 in the Regulation of Monocyte Adhesion to Endothelial Cells.
Parkinson Disease
The role of LRRK2 on PKA-NF?B pathway in microglia cells: implications for Parkinson's disease.
Parkinson Disease
The role of posttranslational modifications of ?-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors.
Parkinson Disease
The role of Rab GTPases in the pathobiology of Parkinson' disease.
Parkinson Disease
The role of SNCA and MAPT in Parkinson disease and LRRK2 parkinsonism in the Tunisian Arab-Berber population.
Parkinson Disease
The screening of the 3'UTR sequence of LRRK2 identified an association between the rs66737902 polymorphism and Parkinson's disease.
Parkinson Disease
The small GTPase activity of the ROC domain from LRRK2, a Parkinson's disease related protein.
Parkinson Disease
The SNCA (A53T, A30P, E46K) and LRRK2 (G2019S) mutations are rare cause of Parkinson's disease in South Indian patients.
Parkinson Disease
The Therapeutic Potential of LRRK2 and Alpha-synuclein in Parkinson's Disease.
Parkinson Disease
The unconventional G-protein cycle of LRRK2 and Roco proteins.
Parkinson Disease
The Unlikely Partnership Between LRRK2 and ?-Synuclein in Parkinson's Disease.
Parkinson Disease
The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.
Parkinson Disease
The WD40 domain is required for LRRK2 neurotoxicity.
Parkinson Disease
Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila.
Parkinson Disease
Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy.
Parkinson Disease
Tom70 Is Essential for PINK1 Import into Mitochondria.
Parkinson Disease
Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation.
Parkinson Disease
Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.
Parkinson Disease
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with ?-synuclein fibrils.
Parkinson Disease
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.
Parkinson Disease
Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice.
Parkinson Disease
Triazolopyridazine LRRK2 kinase inhibitors.
Parkinson Disease
Two Methods to Analyze LRRK2 Functions Under Lysosomal Stress: The Measurements of Cathepsin Release and Lysosomal Enlargement.
Parkinson Disease
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.
Parkinson Disease
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Parkinson Disease
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.
Parkinson Disease
Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.
Parkinson Disease
Understanding the role of glycogen synthase kinase-3 in L-DOPA-induced dyskinesia in Parkinson's disease.
Parkinson Disease
Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
Parkinson Disease
Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.
Parkinson Disease
Unregulated mitochondrial GSK3beta activity results in NADH: ubiquinone oxidoreductase deficiency.
Parkinson Disease
Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers.
Parkinson Disease
Using KASP technique to screen LRRK2 G2019S mutation in a large Tunisian cohort.
Parkinson Disease
Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2).
Parkinson Disease
Validity and utility of a LRRK2 G2019S mutation test for the diagnosis of Parkinson's disease.
Parkinson Disease
Variable frequency of LRRK2 variants in the Latin American research consortium on the genetics of Parkinson's disease (LARGE-PD), a case of ancestry.
Parkinson Disease
Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway.
Parkinson Disease
Visual dysfunction in Parkinson's disease.
Parkinson Disease
Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection.
Parkinson Disease
Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.
Parkinson Disease
What Have We Learned from Cerebrospinal Fluid Studies about Biomarkers for Detecting LRRK2 Parkinson's Disease Patients and Healthy Subjects with Parkinson's-Associated LRRK2 Mutations?
Parkinson Disease
When does postural instability appear in monogenic parkinsonisms? An individual-patient meta-analysis.
Parkinson Disease
Wild-type and mutant (G2019S) leucine-rich repeat kinase 2 (LRRK2) associate with subunits of the translocase of outer mitochondrial membrane (TOM) complex.
Parkinson Disease
Wild-type LRRK2 as a new potential therapeutic target in idiopathic Parkinson's disease.
Parkinson Disease
Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway.
Parkinson Disease
Withaferin A Regulates LRRK2 Levels by Interfering with the Hsp90- Cdc37 Chaperone Complex.
Parkinson Disease
Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review.
Parkinson Disease
WSB1: from homeostasis to hypoxia.
Parkinson Disease
Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.
Parkinson Disease
[11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat.
Parkinson Disease
[A PARK8 form of Parkinson's disease: a mutational analysis of the LRRK2 gene in Russian population]
Parkinson Disease
[Advance of the study on LRRK2 gene in Parkinson's disease]
Parkinson Disease
[Genetic screening for the LRRK2, G2019S and R1441 codon mutations in Parkinson's disease patients from Extremadura, Spain]
Parkinson Disease
[LRRK2: a gene belonging to the ROCO family is implicated in the Parkinson's disease]
Parkinson Disease
[Molecular basis of Parkinson's disease linked with mutations in the LRRK2 gene].
Parkinson Disease
[Mutation in LRRK2 is associated with familial presentation of Parkinson's disease in a Chilean kindred.]
Parkinson Disease
[Pathogenesis of Parkinson's disease through LRRK2 mutation].
Parkinson Disease
[The absence of the common LRRK2 G2019S mutation in 120 young onset Hungarian Parkinon's disease patients].
Parkinson Disease, Secondary
Dynamic interaction of genetic risk factors and cocaine abuse in the background of Parkinsonism - a case report.
Parkinsonian Disorders
(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.
Parkinsonian Disorders
6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
Parkinsonian Disorders
A case of ?-synuclein gene duplication presenting with head-shaking movements.
Parkinsonian Disorders
A common leucine-rich repeat kinase 2 gene mutation in familial and sporadic Parkinson's disease in Russia.
Parkinsonian Disorders
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
Parkinsonian Disorders
A comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism.
Parkinsonian Disorders
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
Parkinsonian Disorders
A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.
Parkinsonian Disorders
A new approach to Parkinson's disease: inhibition of leucine-rich repeat kinase-2.
Parkinsonian Disorders
A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease.
Parkinsonian Disorders
A tangled web - tau and sporadic Parkinson's disease.
Parkinsonian Disorders
Advances in the Genetics of Parkinson's Disease: A Guide for the Clinician.
Parkinsonian Disorders
An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.
Parkinsonian Disorders
Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease.
Parkinsonian Disorders
Are interrupted SCA2 CAG repeat expansions responsible for parkinsonism?
Parkinsonian Disorders
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Parkinsonian Disorders
Autosomal dominant Parkinson's disease: Incidence of mutations in LRRK2, SNCA, VPS35 and GBA genes in Brazil.
Parkinsonian Disorders
Biochemical and pathological characterization of Lrrk2.
Parkinsonian Disorders
Brain-derived neurotrophic factor (BDNF) genetic polymorphism greatly increases risk of leucine-rich repeat kinase 2 (LRRK2) for Parkinson's disease.
Parkinsonian Disorders
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Parkinsonian Disorders
Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism.
Parkinsonian Disorders
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.
Parkinsonian Disorders
Clinical features of LRRK2 parkinsonism.
Parkinsonian Disorders
Clinical features of LRRK2-associated Parkinson's disease in central Norway.
Parkinsonian Disorders
Clinical heterogeneity of LRRK2 p.I2012T mutation.
Parkinsonian Disorders
Clinical heterogeneity of the LRRK2 G2019S mutation.
Parkinsonian Disorders
Co-occurrence of sporadic parkinsonism and late-onset Alzheimer's disease in a Brazilian male with the LRRK2 p.G2019S mutation.
Parkinsonian Disorders
Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation.
Parkinsonian Disorders
Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy.
Parkinsonian Disorders
Contribution of glucocerebrosidase mutation in a large cohort of sporadic Parkinson's disease in Taiwan.
Parkinsonian Disorders
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Parkinsonian Disorders
Deciphering the role of heterozygous mutations in genes associated with parkinsonism.
Parkinsonian Disorders
Digenic parkinsonism: investigation of the synergistic effects of PRKN and LRRK2.
Parkinsonian Disorders
Disease penetrance of late-onset parkinsonism: a meta-analysis.
Parkinsonian Disorders
Disease progression in LRRK2 parkinsonism.
Parkinsonian Disorders
DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study.
Parkinsonian Disorders
Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity.
Parkinsonian Disorders
Dynamic interaction of genetic risk factors and cocaine abuse in the background of Parkinsonism - a case report.
Parkinsonian Disorders
Effective long-term subthalamic stimulation in PARK8 positive Parkinson's disease.
Parkinsonian Disorders
Emerging views of mitophagy in immunity and autoimmune diseases.
Parkinsonian Disorders
Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain.
Parkinsonian Disorders
Expression and phosphorylation of glutamate receptor subunits and CaMKII in a mouse model of Parkinsonism.
Parkinsonian Disorders
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.
Parkinsonian Disorders
Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.
Parkinsonian Disorders
G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy.
Parkinsonian Disorders
Gender differences in the risk of familial parkinsonism: beyond LRRK2?
Parkinsonian Disorders
Genealogical studies in LRRK2-associated Parkinson's disease in central Norway.
Parkinsonian Disorders
Genes associated with Parkinson syndrome.
Parkinsonian Disorders
Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism.
Parkinsonian Disorders
Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.
Parkinsonian Disorders
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Parkinsonian Disorders
Genetic susceptibility loci, environmental exposures, and Parkinson's disease: A case-control study of gene-environment interactions.
Parkinsonian Disorders
Genetics and epigenetics of Parkinson's disease.
Parkinsonian Disorders
Genetics and genomics of Parkinson's disease.
Parkinsonian Disorders
Genome Editing and the Problem of Tetraploidy in Cell Modeling of the Genetic Form of Parkinsonism.
Parkinsonian Disorders
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
Parkinsonian Disorders
Genotype-Phenotype Relations for the Atypical Parkinsonism Genes: MDSGene Systematic Review.
Parkinsonian Disorders
Glucocerebrosidase mutations are not found in association with LRRK2 G2019S in subjects with parkinsonism.
Parkinsonian Disorders
Glycogen Synthase Kinase 3beta and Its Phosphorylated Form (Y216) in the Paraquat-Induced Model of Parkinsonism.
Parkinsonian Disorders
Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism.
Parkinsonian Disorders
Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease.
Parkinsonian Disorders
Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.
Parkinsonian Disorders
Hyposmia in G2019S LRRK2-related parkinsonism: clinical and pathologic data.
Parkinsonian Disorders
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.
Parkinsonian Disorders
Identification of potential protein interactors of Lrrk2.
Parkinsonian Disorders
Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
Parkinsonian Disorders
Impact of recent genetic findings in Parkinson's disease.
Parkinsonian Disorders
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
Parkinsonian Disorders
Intact working memory in non-manifesting LRRK2 carriers - an fMRI study.
Parkinsonian Disorders
Interface between tauopathies and synucleinopathies: A tale of two proteins.
Parkinsonian Disorders
Knockdown transgenic Lrrk Drosophila resists paraquat-induced locomotor impairment and neurodegeneration: A therapeutic strategy for Parkinson's disease.
Parkinsonian Disorders
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.
Parkinsonian Disorders
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.
Parkinsonian Disorders
Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3? activity.
Parkinsonian Disorders
LRRK2 and Parkinson disease.
Parkinsonian Disorders
LRRK2 G2019S mutation and Parkinson's disease: A clinical, neuropsychological and neuropsychiatric study in a large Italian sample.
Parkinsonian Disorders
LRRK2 G2019S mutation in Parkinson's disease: A neuropsychological and neuropsychiatric study in a large Algerian cohort.
Parkinsonian Disorders
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Parkinsonian Disorders
Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.
Parkinsonian Disorders
LRRK2 gene and tremor-dominant parkinsonism.
Parkinsonian Disorders
LRRK2 Gly2385Arg variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
Parkinsonian Disorders
LRRK2 in Parkinson's disease: protein domains and functional insights.
Parkinsonian Disorders
LRRK2 mutations and Parkinsonism.
Parkinsonian Disorders
LRRK2 mutations are a common cause of Parkinson's disease in Spain.
Parkinsonian Disorders
LRRK2 mutations are not common in Alzheimer's disease.
Parkinsonian Disorders
LRRK2 mutations in a clinic-based cohort of Parkinson's disease.
Parkinsonian Disorders
LRRK2 parkinsonism in Tunisia and Norway: a comparative analysis of disease penetrance.
Parkinsonian Disorders
LRRK2 Parkinsonism: Does the Response to Gut Bacteria Mitigate the Neurological Picture?
Parkinsonian Disorders
Lrrk2 pathogenic substitutions in Parkinson's disease.
Parkinsonian Disorders
LRRK2 Pathways Leading to Neurodegeneration.
Parkinsonian Disorders
Lrrk2 R1441 substitution and progressive supranuclear palsy.
Parkinsonian Disorders
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.
Parkinsonian Disorders
Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain.
Parkinsonian Disorders
LRRK2: a common pathway for parkinsonism, pathogenesis and prevention?
Parkinsonian Disorders
MAPT IVS1+124 C>G modifies risk of LRRK2 G2385R for Parkinson's disease in Chinese individuals.
Parkinsonian Disorders
Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.
Parkinsonian Disorders
Mendelian forms of Parkinson's disease.
Parkinsonian Disorders
Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function.
Parkinsonian Disorders
Models for LRRK2-Linked Parkinsonism.
Parkinsonian Disorders
Modifiers of LRRK2 parkinsonism: new therapeutic targets.
Parkinsonian Disorders
Molecular genetic findings in LRRK2 American, Canadian and German families.
Parkinsonian Disorders
Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations.
Parkinsonian Disorders
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.
Parkinsonian Disorders
Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data.
Parkinsonian Disorders
Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation.
Parkinsonian Disorders
Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature.
Parkinsonian Disorders
New endemic familial parkinsonism in south Moravia, Czech Republic and its genetical background.
Parkinsonian Disorders
Novel LRRK2 mutations in Parkinsonism.
Parkinsonian Disorders
Olfactory heterogeneity in LRRK2 related Parkinsonism.
Parkinsonian Disorders
PARK8 LRRK2 parkinsonism.
Parkinsonian Disorders
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.
Parkinsonian Disorders
Parkin: a multifaceted ubiquitin ligase.
Parkinsonian Disorders
Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder.
Parkinsonian Disorders
Parkinsonism, Lrrk2 G2019S, and tau neuropathology.
Parkinsonian Disorders
Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
Parkinsonian Disorders
Pathogenic Lrrk2 substitutions and Amyotrophic lateral sclerosis.
Parkinsonian Disorders
Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants.
Parkinsonian Disorders
Phosphatases of ?-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism.
Parkinsonian Disorders
PINK1 protein in normal human brain and Parkinson's disease.
Parkinsonian Disorders
Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease.
Parkinsonian Disorders
Primary Central Nervous System Lymphoma Presenting as Parkinsonism with Atypical MRI Findings and Elevated 14-3-3 Protein.
Parkinsonian Disorders
Protein kinases linked to the pathogenesis of Parkinson's disease.
Parkinsonian Disorders
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.
Parkinsonian Disorders
Role of LRRK2 and SNCA in autosomal dominant Parkinson's disease in Turkey.
Parkinsonian Disorders
Role of LRRK2 variant p.Gly2019Ser in patients with Parkinsonism.
Parkinsonian Disorders
SARS-CoV-2 dysregulation of PTBP1 and YWHAE/Z gene expression: A primer of neurodegeneration.
Parkinsonian Disorders
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Parkinsonian Disorders
Sequence conservation between porcine and human LRRK2.
Parkinsonian Disorders
Serine-409 phosphorylation and oxidative damage define aggregation of human protein tau in yeast.
Parkinsonian Disorders
Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies.
Parkinsonian Disorders
Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile parkinsonism.
Parkinsonian Disorders
Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations.
Parkinsonian Disorders
Sustained Response to Deep Brain Stimulation in LRRK2 Parkinsonism with the Y1699C Mutation.
Parkinsonian Disorders
Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.
Parkinsonian Disorders
Targeting kinases in Parkinson's disease: A mechanism shared by LRRK2, neurotrophins, exenatide, urate, nilotinib and lithium.
Parkinsonian Disorders
Targeting the cannabinoid CB2 receptor to attenuate the progression of motor deficits in LRRK2-transgenic mice.
Parkinsonian Disorders
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.
Parkinsonian Disorders
TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT.
Parkinsonian Disorders
The ancestry of LRRK2 Gly2019Ser parkinsonism.
Parkinsonian Disorders
The biology and pathology of the familial Parkinson's disease protein LRRK2.
Parkinsonian Disorders
The endoplasmic reticulum/mitochondria interface: a subcellular platform for the orchestration of the functions of the PINK1-Parkin pathway?
Parkinsonian Disorders
The familial Parkinsonism gene LRRK2 regulates neurite process morphology.
Parkinsonian Disorders
The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.
Parkinsonian Disorders
The genetics of Parkinson disease.
Parkinsonian Disorders
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.
Parkinsonian Disorders
The nigrostriatal pathway in Creutzfeldt-Jakob disease.
Parkinsonian Disorders
The PINK1/Parkin pathway regulates mitochondrial morphology.
Parkinsonian Disorders
The role of SNCA and MAPT in Parkinson disease and LRRK2 parkinsonism in the Tunisian Arab-Berber population.
Parkinsonian Disorders
The role of the LRRK2 gene in Parkinsonism.
Parkinsonian Disorders
Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screening.
Parkinsonian Disorders
Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment.
Parkinsonian Disorders
Unilateral pallidotomy in a patient with parkinsonism and G2019S LRRK2 mutation.
Parkinsonian Disorders
[Epidemiology and causes of Parkinson's disease].
Parkinsonian Disorders
[LRRK2 is a major gene in North African parkinsonism]
Parkinsonian Disorders
[Parkinson's disease associated to mutation of the LRRK2 gene, mimicking multisystemic atrophy due to the combination of parkinsonism, early-onset dysautonomia and normal cardiac scintigraphy].
Parkinsonian Disorders
{alpha}-Synuclein contributes to GSK-3{beta}-catalyzed Tau phosphorylation in Parkinson's disease models.
Pellagra
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
Penile Neoplasms
Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer.
Perinatal Death
Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.
Perinatal Death
Phenotypic Effects of Homeodomain-Interacting Protein Kinase 2 Deletion in Mice.
Periodontitis
Autophagy upregulates inflammatory cytokines in gingival tissue of patients with periodontitis and lipopolysaccharide-stimulated human gingival fibroblasts.
Periodontitis
Wnt5a up-regulates Periostin through CaMKII pathway to influence periodontal tissue destruction in early periodontitis.
Peripheral Nerve Injuries
Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury.
Peripheral Nerve Injuries
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy.
Peripheral Nerve Injuries
Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration.
Peripheral Nerve Injuries
Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase.
Peripheral Nerve Injuries
Deep Sequencing Reveals the Significant Involvement of cAMP-Related Signaling Pathways Following Sciatic Nerve Crush.
Peripheral Nerve Injuries
Differential expression of CaMKII isoforms and overall kinase activity in rat dorsal root ganglia after injury.
Peripheral Nerve Injuries
Expression of p-Akt in Sensory Neurons and Spinal Cord after Peripheral Nerve Injury.
Peripheral Nerve Injuries
GSK3? inhibitor promotes myelination and mitigates muscle atrophy after peripheral nerve injury.
Peripheral Nerve Injuries
Involvement of spinal phosphorylation cascade of Tyr1472-NR2B, Thr286-CaMKII, and Ser831-GluR1 in neuropathic pain.
Peripheral Nerve Injuries
Protein kinase C? promotes proliferation and migration of schwann cells by activating ERK signaling pathway.
Peripheral Nerve Injuries
The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development.
Peripheral Nervous System Diseases
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Peripheral Nervous System Diseases
Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination.
Peripheral Nervous System Diseases
Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat.
Peripheral Nervous System Diseases
Spinal astrocytic c-Jun N-terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies.
Peripheral Nervous System Diseases
The isoform-specific functions of the c-Jun N-terminal kinase (JNK) in a mouse model of antiretroviral-induced painful peripheral neuropathy.
Peritoneal Fibrosis
Comparison of anti-peritoneal fibrotic effects between an mTORC1-specific blocker and a PI3K/mTOR dual-blocker.
Peritoneal Fibrosis
[Phosphorylation of glycogen synthase kinase-3beta induces epithelial mesenchymal transition in human peritoneal mesothelial cells.]
Peritoneal Neoplasms
Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites.
Peritonitis
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
Peritonitis
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
Peritonitis
Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis.
Peritonitis
The future of RIP2/RICK/CARDIAK as a biomarker of the inflammatory response to infection.
Persistent Hyperplastic Primary Vitreous
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.
Persistent Infection
Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice.
Persistent Infection
How Human Papillomavirus Replication and Immune Evasion Strategies Take Advantage of the Host DNA Damage Repair Machinery.
Peste-des-Petits-Ruminants
Autophagy in farm animals: current knowledge and future challenges.
Peutz-Jeghers Syndrome
A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.
Peutz-Jeghers Syndrome
A case of Peutz-Jeghers syndrome with breast cancer, bilateral sex cord tumor with annular tubules, and adenoma malignum caused by STK11 gene mutation.
Peutz-Jeghers Syndrome
A Clinical and Molecular Genetic Study in 11 Chinese Children with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
A De Novo Mutation of STK11 Gene in a Chinese Patient with Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
A Distinctive Adnexal (Usually Paratubal) Neoplasm Often Associated With Peutz-Jeghers Syndrome and Characterized by STK11 Alterations (STK11 Adnexal Tumor): A Report of 22 Cases.
Peutz-Jeghers Syndrome
A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
Peutz-Jeghers Syndrome
A novel de novo mutation in the serine-threonine kinase STK11 gene in a Korean patient with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.
Peutz-Jeghers Syndrome
A novel germline mutation of the LKB1 gene in a patient with Peutz-Jeghers syndrome with early-onset gastric cancer.
Peutz-Jeghers Syndrome
A novel mutation (c.855delG) in STK11 gene is associated with Peutz-Jeghers syndrome in a Chinese family.
Peutz-Jeghers Syndrome
A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Chinese patients.
Peutz-Jeghers Syndrome
A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Indian patients.
Peutz-Jeghers Syndrome
A novel mutation in the STK11 gene causes heritable Peutz-Jeghers syndrome - a case report.
Peutz-Jeghers Syndrome
A novel pathogenic splice site variation in STK11 gene results in Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer.
Peutz-Jeghers Syndrome
A novel STK11 missense mutation (c.346G?>?T) causing Peutz-Jeghers syndrome in a Chinese male with a negative family history.
Peutz-Jeghers Syndrome
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity.
Peutz-Jeghers Syndrome
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
A tumor of the uterine cervix with a complex histology in a Peutz-Jeghers syndrome patient with genomic deletion of the STK11 exon 1 region.
Peutz-Jeghers Syndrome
Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt.
Peutz-Jeghers Syndrome
Alu-Mediated Genomic Deletion of the Serine/Threonine Protein Kinase 11 (STK11) Gene in Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
An exploration of genotype-phenotype link between Peutz-Jeghers syndrome and STK11: a review.
Peutz-Jeghers Syndrome
Analysis of STK11 Gene Variant in Five Chinese Patients with Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.
Peutz-Jeghers Syndrome
Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4.
Peutz-Jeghers Syndrome
Characterization of the STK11 splicing variant as a normal splicing isomer in a patient with Peutz-Jeghers syndrome harboring genomic deletion of the STK11 gene.
Peutz-Jeghers Syndrome
Clinical and Genetic Analyses of 38 Chinese Patients with Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
Clinical and Genetic Study of Children With Peutz-Jeghers Syndrome Identifies a High Frequency of STK11 De Novo Mutation.
Peutz-Jeghers Syndrome
Clinical characteristics and STK11 gene mutations in Chinese children with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Clinical features, endoscopic polypectomy and STK11 gene mutation in a nine-month-old Peutz-Jeghers syndrome Chinese infant.
Peutz-Jeghers Syndrome
Clinical manifestations and STK11 germline mutations in Taiwanese patients with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Close and regular surveillance is key to prevent severe complications for Peutz-Jeghers syndrome patients without gastrointestinal polyps: case report of a novel STK11 mutation (c.471_472delCT) in a Chinese girl.
Peutz-Jeghers Syndrome
Complete germline deletion of the STK11 gene in a family with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Complete STK11 Deletion and Atypical Symptoms in Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
Controlling the master-upstream regulation of the tumor suppressor LKB1.
Peutz-Jeghers Syndrome
De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Delayed diagnosis of Peutz-Jeghers syndrome due to pathological information loss or mistake in family/personal history.
Peutz-Jeghers Syndrome
Deleterious mis-splicing of STK11 caused by a novel single-nucleotide substitution in the 3' polypyrimidine tract of intron five.
Peutz-Jeghers Syndrome
Different phenotypes including gynecological cancer in three female patients with Peutz-Jeghers syndrome and mutations in the STK11 gene.
Peutz-Jeghers Syndrome
Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis.
Peutz-Jeghers Syndrome
Distinct promoter methylation patterns of LKB1 in the hamartomatous polyps of Peutz-Jeghers syndrome and its potential in gastrointestinal malignancy prediction.
Peutz-Jeghers Syndrome
Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.
Peutz-Jeghers Syndrome
Early genetic testing of STK11 is important for management and genetic counseling for Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Early screening the small bowel is key to protect Peutz-Jeghers syndrome patients from surgery: a novel mutation c.243delG in STK11 gene.
Peutz-Jeghers Syndrome
Emerging Therapeutic Implications of STK11 Mutation: Case Series.
Peutz-Jeghers Syndrome
Evaluation of the contribution of the three breast cancer susceptibility genes CHEK2, STK11, and PALB2 in non-BRCA1/2 French Canadian families with high risk of breast cancer.
Peutz-Jeghers Syndrome
Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Extremely young case of small bowel intussusception due to Peutz-Jeghers syndrome with nonsense mutation of STK11.
Peutz-Jeghers Syndrome
Familial pancreatic carcinoma in Jews.
Peutz-Jeghers Syndrome
Findings from the Peutz-Jeghers syndrome registry of uruguay.
Peutz-Jeghers Syndrome
First report of somatic mosaicism for mutations in STK11 in four patients with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability.
Peutz-Jeghers Syndrome
Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.
Peutz-Jeghers Syndrome
Functional Consequence of the STK11 Exon 7 Duplication Mutation Identified in a Korean Child with Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
Ganglioglioma arising in a Peutz-Jeghers patient: a case report with molecular implications.
Peutz-Jeghers Syndrome
Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Gene of the month: STK11.
Peutz-Jeghers Syndrome
Gene symbol: STK11. Disease: Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Gene symbol: STK11. Disease: Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
Genetic analysis and clinical description of Greek patients with Peutz-Jeghers syndrome: Creation of a National Registry.
Peutz-Jeghers Syndrome
Genetic Causes of Rare Pediatric Ovarian Tumors.
Peutz-Jeghers Syndrome
Genetic screening for Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Genetic testing by cancer site: stomach.
Peutz-Jeghers Syndrome
Genotype-phenotype correlations in Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Germline Mutation Analysis of STK11 Gene Using Direct Sequencing and Multiplex Ligation-Dependent Probe Amplification Assay in Korean Children with Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
Germline mutation in the STK11 gene in a girl with an ovarian Sertoli cell tumour.
Peutz-Jeghers Syndrome
Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.
Peutz-Jeghers Syndrome
Germline mutations of the STK11 gene in Korean Peutz-Jeghers syndrome patients.
Peutz-Jeghers Syndrome
Hamartomatous polyposis syndromes: molecular genetics, neoplastic risk, and surveillance recommendations.
Peutz-Jeghers Syndrome
Hereditary breast cancer: the era of new susceptibility genes.
Peutz-Jeghers Syndrome
Hereditary predisposition to cancers of the digestive tract, breast, gynecological and gonadal: Focus on the Peutz-Jeghers.
Peutz-Jeghers Syndrome
High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients.
Peutz-Jeghers Syndrome
High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
High Resolution Melting analysis as a rapid and efficient method of screening for small mutations in the STK11 gene in patients with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Identification of a novel de novo STK11 mutation in a Chinese child with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Identification of a novel mRNA species of the LKB1/STK11 Peutz-Jeghers serine/threonine kinase.
Peutz-Jeghers Syndrome
Identification of unique heterozygous germline mutation, STK11 (p.F354L), in a child with encapsulated follicular variant of papillary thyroid carcinoma within 6 months of completing treatment for neuroblastoma.
Peutz-Jeghers Syndrome
Implications of Splicing Alterations in the Onset and Phenotypic Variability of a Family with Subclinical Manifestation of Peutz-Jeghers Syndrome: Bioinformatic and Molecular Evidence.
Peutz-Jeghers Syndrome
Intracholecystic Papillary Neoplasms Are Distinct From Papillary Gallbladder Cancers: A Clinicopathologic and Exome-sequencing Study.
Peutz-Jeghers Syndrome
Lack of STK11 gene expression in homozygous twins with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.
Peutz-Jeghers Syndrome
LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.
Peutz-Jeghers Syndrome
LKB1 and cancer: The dual role of metabolic regulation.
Peutz-Jeghers Syndrome
LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest.
Peutz-Jeghers Syndrome
LKB1 Catalytic Activity Contributes to Estrogen Receptor {alpha} Signaling.
Peutz-Jeghers Syndrome
LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.
Peutz-Jeghers Syndrome
LKB1 deletion with the RIP.Cre-transgene modifies pancreatic {beta}-cell morphology and enhances insulin secretion in vivo.
Peutz-Jeghers Syndrome
LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.
Peutz-Jeghers Syndrome
LKB1 modulates lung cancer differentiation and metastasis.
Peutz-Jeghers Syndrome
LKB1 reduces ROS-mediated cell damage via activation of p38.
Peutz-Jeghers Syndrome
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Peutz-Jeghers Syndrome
LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain.
Peutz-Jeghers Syndrome
LKB1, a protein kinase regulating cell proliferation and polarity.
Peutz-Jeghers Syndrome
LKB1, the multitasking tumour suppressor kinase.
Peutz-Jeghers Syndrome
LKB1: cancer, polarity, metabolism, and now fertility.
Peutz-Jeghers Syndrome
Lobular endocervical glandular hyperplasia and peritoneal pigmentation associated with Peutz-Jeghers syndrome due to a germline mutation of STK11.
Peutz-Jeghers Syndrome
Mapping of a translocation breakpoint in a Peutz-Jeghers hamartoma to the putative PJS locus at 19q13.4 and mutation analysis of candidate genes in polyp and STK11-negative PJS cases.
Peutz-Jeghers Syndrome
Molecular characterization of gastric-type endocervical adenocarcinoma using next-generation sequencing.
Peutz-Jeghers Syndrome
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Peutz-Jeghers Syndrome
Molecular insights into Peutz-Jeghers syndrome: two probands with a germline mutation of LKB1.
Peutz-Jeghers Syndrome
Molecular mechanisms of LKB1 induced cell cycle arrest.
Peutz-Jeghers Syndrome
mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4).
Peutz-Jeghers Syndrome
Mutational analysis of STK11 gene in ovarian carcinomas.
Peutz-Jeghers Syndrome
Mutations in the human LKB1/STK11 gene.
Peutz-Jeghers Syndrome
Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Novel and Recurrent Mutations of STK11 Gene in Six Chinese Cases with Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
Novel germline STK11 variants and breast cancer phenotype identified in an Indian cohort of Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Novel mutations in the STK11 gene in Thai patients with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Novel serine/threonine kinase 11 gene mutations in Peutz-Jeghers syndrome patients and endoscopic management.
Peutz-Jeghers Syndrome
Organ-sparing surgery of the bilateral testicular large cell calcifying sertoli cell tumor in patient with atypical Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Peutz-Jeghers Syndrome
Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for prepubertal gynecomastia in boys with Peutz Jeghers Syndrome.
Peutz-Jeghers Syndrome
Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling.
Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome complicated by gastric-type cervical mucinous carcinoma and primary peritoneal carcinoma.
Peutz-Jeghers Syndrome
Peutz-Jeghers Syndrome Diagnosed in a Schizophrenic Patient with a Large Deletion in the STK11 Gene.
Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome with germline mutation of STK11.
Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome: a new understanding.
Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome: early clinical expression of a new STK11 gene variant.
Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome: four novel inactivating germline mutations in the STK11 gene. Mutations in brief no. 227. Online.
Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome: molecular analysis of a three-generation kindred with a novel defect in the serine threonine kinase gene STK11.
Peutz-Jeghers Syndrome
Polycystic ovary syndrome (PCOS) with melanocytic mucosal macules: the role of STK11 gene polymorphisms in PCOS and Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Prader-Willi Syndrome due to an Unbalanced de novo Translocation t(15;19)(q12;p13.3).
Peutz-Jeghers Syndrome
Prediction of Deleterious Non-synonymous SNPs of Human STK11 Gene by Combining Algorithms, Molecular Docking, and Molecular Dynamics Simulation.
Peutz-Jeghers Syndrome
Prenatal diagnosis in a hereditary Peutz-Jeghers syndrome family with high cancer risk.
Peutz-Jeghers Syndrome
Primary gastric adenocarcinoma in a patient with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Recurrent small intestine intussusception in a patient with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.
Peutz-Jeghers Syndrome
Relative frequency and morphology of cancers in STK11 mutation carriers.
Peutz-Jeghers Syndrome
Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient.
Peutz-Jeghers Syndrome
Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2.
Peutz-Jeghers Syndrome
Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA.
Peutz-Jeghers Syndrome
Serine/Threonine Kinase 11 Plays a Canonical Role in Malignant Progression of KRAS-mutant and GNAS-wild-type Intraductal Papillary Mucinous Neoplasms of the Pancreas.
Peutz-Jeghers Syndrome
Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.
Peutz-Jeghers Syndrome
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.
Peutz-Jeghers Syndrome
Specific Alu elements involved in a significant percentage of copy number variations of the STK11 gene in patients with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
STK11 Domain XI Mutations: Candidate Genetic Drivers Leading to the Development of Dysplastic Polyps in Peutz-Jeghers Syndrome.
Peutz-Jeghers Syndrome
STK11 gene analysis reveals a significant number of splice mutations in Chinese PJS patients.
Peutz-Jeghers Syndrome
STK11 genotyping and cancer risk in Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.
Peutz-Jeghers Syndrome
STK11 status and intussusception risk in Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.
Peutz-Jeghers Syndrome
Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling.
Peutz-Jeghers Syndrome
T-Cell Mutation Leads to GI Polyps.
Peutz-Jeghers Syndrome
Targeted Genomic Profiling of Female Adnexal Tumors of Probable Wolffian Origin (FATWO).
Peutz-Jeghers Syndrome
Targeting the LKB1 tumor suppressor.
Peutz-Jeghers Syndrome
The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.
Peutz-Jeghers Syndrome
The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis.
Peutz-Jeghers Syndrome
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
Peutz-Jeghers Syndrome
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice.
Peutz-Jeghers Syndrome
The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development.
Peutz-Jeghers Syndrome
The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1.
Peutz-Jeghers Syndrome
Three novel mutations of STK11 gene in Chinese patients with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Truncating mutations in Peutz-Jeghers syndrome are associated with more polyps, surgical interventions and cancers.
Peutz-Jeghers Syndrome
Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC).
Peutz-Jeghers Syndrome
Two cases of somatic STK11 mosaicism in Danish patients with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Two novel STK11 mutations in three Chinese families with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Two variants in STK11 gene in Chinese patients with Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice.
Peutz-Jeghers Syndrome
[A serine/threonine kinase gene defective in Peutz-Jeghers syndrome]
Peutz-Jeghers Syndrome
[Analysis of STK11 gene variants among 64 patients with Peutz-Jeghers syndrome].
Peutz-Jeghers Syndrome
[Mutated serine-threonine kinase gene (STK11) is the cause of Peutz-Jeghers syndrome]
Peutz-Jeghers Syndrome
[Mutation analysis of STK11 gene coding region for 20 Chinese patients with Peutz-Jeghers syndrome].
Peutz-Jeghers Syndrome
[Mutation analysis of STK11 gene in a Chinese family with Peutz-Jeghers syndrome].
Peutz-Jeghers Syndrome
[Mutations of the STK11 and FHIT genes among patients with Peutz-Jeghers syndrome].
Peutz-Jeghers Syndrome
[Patient with Peutz-Jeghers syndrome and liver metastases from an unknown primary tumor]
Peutz-Jeghers Syndrome
[Rare hereditary syndromes associated with polyposis and the development of malignant tumors].
Peutz-Jeghers Syndrome
[Sequence polymorphism of the promoter region of gene STK11 in patients with Peutz-Jeghers syndrome]
Peutz-Jeghers Syndrome
[STK11 gene mutation in Chinese with PJS]
Pharyngeal Neoplasms
Lower ataxia telangiectasia mutated (ATM) mRNA expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients.
Pharyngeal Neoplasms
Significance of interleukin-6 signaling in the resistance of pharyngeal cancer to irradiation and the epidermal growth factor receptor inhibitor.
Pheochromocytoma
15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis.
Pheochromocytoma
6-Methylmercaptopurine riboside is a potent and selective inhibitor of nerve growth factor-activated protein kinase N.
Pheochromocytoma
A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells.
Pheochromocytoma
Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway.
Pheochromocytoma
Characterization of the cytoplasmic proline-directed protein kinase in proliferative cells and tissues as a heterodimer comprised of p34cdc2 and p58cyclin A.
Pheochromocytoma
Expression of activin A and its receptors in human pheochromocytomas.
Pheochromocytoma
Expression of the choline acetyltransferase gene depends on protein kinase A activity.
Pheochromocytoma
Expression of tyrosine hydroxylase gene in cultured hypothalamic cells: roles of protein kinase A and C.
Pheochromocytoma
Growth factor induced MEK activation is primarily mediated by an activator different from c-raf.
Pheochromocytoma
GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.
Pheochromocytoma
Hypoxia regulates the cAMP- and Ca2+/calmodulin signaling systems in PC12 cells.
Pheochromocytoma
Identification of a novel proline-directed serine/threonine protein kinase in rat pheochromocytoma.
Pheochromocytoma
K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.
Pheochromocytoma
Lithium ions: a novel treatment for pheochromocytomas and paragangliomas.
Pheochromocytoma
MAPKAP kinase-2 is a primary response gene induced by depolarization in PC12 cells and in brain.
Pheochromocytoma
Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells.
Pheochromocytoma
Mitogenic and antimitogenic effects of pituitary adenylate cyclase-activating polypeptide (PACAP) in adult rat chromaffin cell cultures.
Pheochromocytoma
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
Pheochromocytoma
Mutations that abolish the ability of Ha-Ras to associate with Raf-1.
Pheochromocytoma
Nerve growth factor increases nicotinic ACh receptor gene expression and current density in wild-type and protein kinase A-deficient PC12 cells.
Pheochromocytoma
Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells.
Pheochromocytoma
Overexpression of 14-3-3 protein protects pheochromocytoma cells against 1-methyl-4-phenylpyridinium toxicity.
Pheochromocytoma
Overexpression of glia maturation factor (GMF) in PC12 pheochromocytoma cells activates p38 MAP kinase, MAPKAP kinase-2, and tyrosine hydroxylase.
Pheochromocytoma
Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol.
Pheochromocytoma
Regulation of protein kinase activities in PC12 pheochromocytoma cells.
Pheochromocytoma
Signaling pathways for antigen receptor-mediated induction of transcription factor CREB in B lymphocytes.
Pheochromocytoma
The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK).
Pheochromocytoma
The MAP kinase pathway is upstream of the activation of GSK3beta that enables it to phosphorylate MAP1B and contributes to the stimulation of axon growth.
Pheochromocytoma
The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.
Pheochromocytoma
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Pheochromocytoma
When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?
Pheochromocytoma
ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells.
Photophobia
Phototropin-dependent weak and strong light responses in the determination of branch position in the moss Physcomitrella patens.
Photophobia
Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments.
Pick Disease of the Brain
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Pick Disease of the Brain
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.
Pick Disease of the Brain
The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions.
Pinealoma
Immunocytochemical detection of 14-3-3 in primary nervous system tumors.
Pituitary Neoplasms
A pleiomorphic GH pituitary adenoma from a Carney complex patient displays universal allelic loss at the protein kinase A regulatory subunit 1A (PRKARIA) locus.
Pituitary Neoplasms
Cell cycle dysregulation in pituitary oncogenesis.
Pituitary Neoplasms
Enhanced protein kinase B/Akt signalling in pituitary tumours.
Pituitary Neoplasms
G protein mutations in pituitary tumors: a study on Turkish patients.
Pituitary Neoplasms
Germline deletion and a somatic mutation of the PRKAR1A gene in a Carney complex-related pituitary adenoma.
Pituitary Neoplasms
Harvey Cushing Treated the First Known Patient With Carney Complex.
Pituitary Neoplasms
Identification of Potential Biomarkers with Diagnostic Value in Pituitary Adenomas Using Prediction Analysis for Microarrays Method.
Pituitary Neoplasms
Identification of Seven Cell Cycle-Related Genes with Unfavorable Prognosis and Construction of their TF-miRNA-mRNA regulatory network in Breast Cancer.
Pituitary Neoplasms
Low levels of raf kinase inhibitory protein in growth hormone-secreting pituitary adenomas correlate with poor response to octreotide treatment.
Pituitary Neoplasms
Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line GH3.
Pituitary Neoplasms
Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.
Pituitary Neoplasms
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Pituitary Neoplasms
Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
Pituitary Neoplasms
Pivotal role of NF-?B in cellular senescence of experimental pituitary tumours.
Pituitary Neoplasms
RIalpha Influences Cellular Proliferation in Cancer Cells by Transporting RFC40 into the Nucleus.
Pituitary Neoplasms
Selective expression and immunogenicity of the cancer/testis antigens SP17, AKAP4 and PTTG1 in non-small cell lung cancer: new candidates for active immunotherapy.
Pituitary Neoplasms
Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors.
Pituitary Neoplasms
The roles of adenosine 3',5'-cyclic monophosphate-dependent protein kinase A and protein kinase C in stimulus-secretion coupling in AtT-20 cells.
Pituitary Neoplasms
Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A.
Pituitary Neoplasms
Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin/transforming growth factor-beta receptors in human pituitary adenomas.
Pituitary Neoplasms
Widely metastatic atypical pituitary adenoma with mTOR pathway STK11(F298L) mutation treated with everolimus therapy.
Placental Insufficiency
Comparative proteomic analysis associated with term placental insufficiency in cloned pig.
Placental Insufficiency
eNOS, NO, and the activation of ERK and AKT signaling at mid-gestation and near-term in an ovine model of intrauterine growth restriction.
Plague
Antigenic profiling of yersinia pestis infection in the Wyoming coyote (Canis latrans).
Plague
Targeting plague virulence factors: a combined machine learning method and multiple conformational virtual screening for the discovery of Yersinia protein kinase A inhibitors.
Plague
The activities of the Yersinia protein kinase A (YpkA) and outer protein J (YopJ) virulence factors converge on an eIF2alpha kinase.
Plant Diseases
A unique wheat disease resistance-like gene governs effector-triggered susceptibility to necrotrophic pathogens.
Plant Diseases
Plant pathology. Resistance crumbles?
Plant Diseases
Proteomic Analysis of Mature Lagenaria siceraria Seed.
Plant Diseases
RNA-seq bulked segregant analysis combined with KASP genotyping rapidly identified PmCH7087 as responsible for powdery mildew resistance in wheat.
Plasmacytoma
Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma.
Pleural Effusion
Characterisation of the Phosphatidylinositol 3-Kinase Pathway in Non-Small Cell Lung Cancer Cells Isolated from Pleural Effusions.
Pleurisy
Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice.
Pneumonia
3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
Pneumonia
ATM Polymorphisms Are Associated With Risk of Radiation-Induced Pneumonitis.
Pneumonia
CaMKII Oxidation Regulates Cockroach Allergen-Induced Mitophagy in Asthma.
Pneumonia
Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies.
Pneumonia
Ghrelin protects alveolar macrophages against lipopolysaccharide-induced apoptosis through growth hormone secretagogue receptor 1a-dependent c-Jun N-terminal kinase and Wnt/?-catenin signaling and suppresses lung inflammation.
Pneumonia
GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis.
Pneumonia
Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx.
Pneumonia
MAP kinase activation and apoptosis in lung tissues from patients with idiopathic pulmonary fibrosis.
Pneumonia
miR-495 targets ROCK1 to inhibit lipopolysaccharides-induced WI-38 cells apoptosis and inflammation.
Pneumonia
Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology.
Pneumonia
Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy.
Pneumonia
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis.
Pneumonia
Regulation of PTEN activity by p38?-PKD1 signaling in neutrophils confers inflammatory responses in the lung.
Pneumonia
Single-nucleotide polymorphisms of TGF?1 and ATM associated with radiation-induced pneumonitis: a prospective cohort study of thoracic cancer patients in China.
Pneumonia
Sirolimus alters lung pathology and viral load following influenza A virus infection.
Polycystic Kidney Diseases
Casein kinase 1? and 1? as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.
Polycystic Kidney Diseases
Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease.
Polycystic Kidney Diseases
High-resolution genetic localization of a modifying locus affecting disease severity in the juvenile cystic kidneys (jck) mouse model of polycystic kidney disease.
Polycystic Kidney Diseases
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.
Polycystic Kidney Diseases
Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.
Polycystic Kidney Diseases
The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD).
Polycystic Kidney Diseases
The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.
Polycystic Kidney Diseases
Therapies to slow polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway.
Polycystic Kidney, Autosomal Dominant
Celecoxib inhibits growth of human autosomal dominant polycystic kidney cyst-lining epithelial cells through the VEGF/Raf/MAPK/ERK signaling pathway.
Polycystic Kidney, Autosomal Dominant
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys.
Polycystic Kidney, Autosomal Dominant
Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease.
Polycystic Kidney, Autosomal Dominant
Modulation of polycystic kidney disease by G-protein coupled receptors and cyclic AMP signaling.
Polycystic Kidney, Autosomal Dominant
Olive leaf extract counteracts cell proliferation and cyst growth in an in vitro model of autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease.
Polycystic Kidney, Autosomal Dominant
Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model.
Polycystic Kidney, Autosomal Dominant
Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.
Polycystic Kidney, Autosomal Dominant
The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.
Polycystic Kidney, Autosomal Dominant
Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease.
Polycystic Kidney, Autosomal Recessive
The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD).
Polycystic Ovary Syndrome
Adipocytes from women with polycystic ovary syndrome demonstrate altered phosphorylation and activity of glycogen synthase kinase 3.
Polycystic Ovary Syndrome
Association between BMI and gene expression of anti-Müllerian hormone and androgen receptor in human granulosa cells in women with and without polycystic ovary syndrome.
Polycystic Ovary Syndrome
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Polycystic Ovary Syndrome
Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome
Dysregulation of the anti-Müllerian hormone system by steroids in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Early steps in androgen biosynthesis: from cholesterol to DHEA.
Polycystic Ovary Syndrome
Is pharmacogenomics our future? Metformin, ovulation and polymorphism of the STK11 gene in polycystic ovary syndrome.
Polycystic Ovary Syndrome
Loss of LH-induced down-regulation of anti-Mullerian hormone receptor expression may contribute to anovulation in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.
Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) with melanocytic mucosal macules: the role of STK11 gene polymorphisms in PCOS and Peutz-Jeghers syndrome.
Polycystic Ovary Syndrome
Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome.
Polycystic Ovary Syndrome
The casein kinase 2? promotes the occurrence polycystic ovary syndrome.
Polycystic Ovary Syndrome
[Effect of Acupuncture on Reproductive Endocrine and p-Akt Protein Expression in Polycystic Ovary Syndrome Rats with Insulin Resistance].
Polyuria
Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria.
Porcine Reproductive and Respiratory Syndrome
Autophagy and innate immunity: Insights from invertebrate model organisms.
Porcine Reproductive and Respiratory Syndrome
Characterization of the interactome of the porcine reproductive and respiratory syndrome virus (PRRSV) NSP2 protein reveals the hyper variable region as a binding platform for association with 14-3-3 proteins.
Porcine Reproductive and Respiratory Syndrome
Viral strategies for triggering and manipulating mitophagy.
Posterior Leukoencephalopathy Syndrome
Reversible posterior leukoencephalopathy syndrome induced by RAF kinase inhibitor BAY 43-9006.
Pre-Eclampsia
14-3-3 tau (YWHAQ) gene promoter hypermethylation in human placenta of preeclampsia.
Pre-Eclampsia
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.
Pre-Eclampsia
Gene expression profiling of placentas affected by pre-eclampsia.
Pre-Eclampsia
LncRNA MALAT1 regulates trophoblast cells migration and invasion via miR-206/IGF-1 axis.
Pre-Eclampsia
Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1.
Pre-Eclampsia
PKC delta in preeclamptic placentas promotes Bax dissociation from 14-3-3 zeta through 14-3-3 zeta phosphorylation.
Pre-Eclampsia
ROCK2 allelic variants are not associated with preeclampsia susceptibility in the Finnish population.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Aurora A kinase as a target for therapy in TCF3-HLF rearranged acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Converting cell lines representing hematological malignancies from glucocorticoid-resistant to glucocorticoid-sensitive: signaling pathway interactions.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Epigenetic changes in the DAP-kinase CpG island in pediatric lymphoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of PIM-2 and NF-?B genes is increased in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and is associated with complete remission rate and overall survival.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hypermethylation of Death-Associated Protein Kinase 1 differentiates natural killer cell lines from cell lines derived from T-acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Long non-coding RNA AWPPH interacts with ROCK2 and regulates the proliferation and apoptosis of cancer cells in pediatric T-cell acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Optimal IL-7R-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on CK2 activity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Restoring Ikaros's wings to solve a leukemia maze.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Simultaneous Inhibition of Protein Kinase CK2 and Dihydrofolate Reductase Results in Synergistic Effect on Acute Lymphoblastic Leukemia Cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Change of ROCK1 Gene Expression Level in Patients with Acute Lymphoblastic Leukemia and Its Clinical Significance].
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-?B.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
[Change of ROCK1 Gene Expression Level in Patients with Acute Lymphoblastic Leukemia and Its Clinical Significance].
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
[E-cadherin Expression in Children with Acute Leukemia and Its Clinical Significance].
Prediabetic State
Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients.
Prediabetic State
Liraglutide inhibits the progression of prediabetes in rats by reducing Raf-1 kinase inhibitor protein.
Prediabetic State
Metabolic syndrome does not influence the phenotype of LRRK2 and GBA related Parkinson's disease.
Prediabetic State
Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca(2+) release events in a rodent model of early stage diabetes: The arrhythmogenic substrate.
Prediabetic State
The Impact of Chronic Glycogen Synthase Kinase-3 Inhibition on Remodeling of Normal and Pre-Diabetic Rat Hearts.
Premature Birth
Hepatic Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons.
Premature Birth
The Preventive Effects of Quercetin on Preterm Birth Based on Network Pharmacology and Bioinformatics.
Primary Dysautonomias
Autonomic dysfunction in genetic forms of synucleinopathies.
Primary Dysautonomias
Clinical profiles associated with LRRK2 and GBA mutations in Brazilians with Parkinson's disease.
Primary Dysautonomias
[Parkinson's disease associated to mutation of the LRRK2 gene, mimicking multisystemic atrophy due to the combination of parkinsonism, early-onset dysautonomia and normal cardiac scintigraphy].
Primary Myelofibrosis
Kinase signaling and targeted therapy for primary myelofibrosis.
Primary Ovarian Insufficiency
Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure.
Primary Ovarian Insufficiency
Tripterygium glycosides induce premature ovarian failure in rats by promoting p53 phosphorylation and activating the serine/threonine kinase 11-p53-p21 signaling pathway.
Prion Diseases
A case report of genetic prion disease with two different PRNP variants.
Prion Diseases
A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.
Prion Diseases
A polymorphism in the YWHAH gene encoding 14-3-3 eta that is not associated with sporadic Creutzfeldt-Jakob disease (CJD).
Prion Diseases
A rare case of rapidly progressive dementia with elevated RT-QuIC and negative 14-3-3 and tau proteins.
Prion Diseases
Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease.
Prion Diseases
Cerebrospinal fluid non-phosphorylated tau in the differential diagnosis of Creutzfeldt-Jakob disease: a comparative prospective study with 14-3-3.
Prion Diseases
Changes of tau profiles in brains of the hamsters infected with scrapie strains 263K or 139A possibly associated with the alteration of phosphate kinases.
Prion Diseases
Comparison between plasma and cerebrospinal fluid biomarkers for the early diagnosis and association with survival in prion disease.
Prion Diseases
Creutzfeldt-Jakob Disease May Present Early With Unusual Bulbar Predominance.
Prion Diseases
Creutzfeldt-Jakob disease surveillance in Australia: update to 31 December 2018.
Prion Diseases
Creutzfeldt-Jakob disease surveillance in Australia: update to 31 December 2019.
Prion Diseases
Creutzfeldt-Jakob disease surveillance in Australia: update to 31 December 2020.
Prion Diseases
Diagnosis of prion diseases by RT-QuIC results in improved surveillance.
Prion Diseases
Diagnostic and prognostic performance of CSF ?-synuclein in prion disease in the context of rapidly progressive dementia.
Prion Diseases
Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.
Prion Diseases
Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients.
Prion Diseases
Different expression patterns of CK2 subunits in the brains of experimental animals and patients with transmissible spongiform encephalopathies.
Prion Diseases
High sensitivity of an ELISA kit for detection of the gamma-isoform of 14-3-3 proteins: usefulness in laboratory diagnosis of human prion disease.
Prion Diseases
Increase of neuron-specific enolase in patients with Creutzfeldt-Jakob disease.
Prion Diseases
Infection of Prions and Treatment of PrP106-126 Alter the Endogenous Status of Protein 14-3-3 and Trigger the Mitochondrial Apoptosis Possibly via Activating Bax Pathway.
Prion Diseases
Lack of association between 14-3-3 beta gene (YWHAB) polymorphisms and sporadic Creutzfeldt-Jakob disease (CJD).
Prion Diseases
Novel approaches in diagnosis and therapy of Creutzfeldt-Jakob disease.
Prion Diseases
Positive 14-3-3 and tau proteins in a sporadic Creutzfeldt-Jakob disease case and a brief perspective of prion diseases in Colombia.
Prion Diseases
Profiles of 14-3-3 and Total Tau in CSF Samples of Chinese Patients of Different Genetic Prion Diseases.
Prion Diseases
Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
Prion Diseases
Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea.
Prion Diseases
Real-Time Quaking-Induced Conversion for Diagnosis of Prion Disease.
Prion Diseases
Specific 14-3-3 isoform detection and immunolocalization in prion diseases.
Prion Diseases
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Prion Diseases
The 14-3-3 brain protein and transmissible spongiform encephalopathy.
Prion Diseases
The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.
Prion Diseases
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
Prion Diseases
The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein.
Prion Diseases
Validation of 14-3-3 Protein as a Marker in Sporadic Creutzfeldt-Jakob Disease Diagnostic.
Prion Diseases
[Analyses of 14-3-3 protein in the cerebrospinal fluid in Creutzfeldt-Jakob disease. Preliminary report]
Prion Diseases
[Bacillus anthracis, prions, Coxiella burnetii]
Prion Diseases
[Clinical characteristics and laboratory findings in prion diseases]
Prion Diseases
[CSF analysis of patients with prion disease by biomarkers and real-time qucking-induced conversion (RT-QUIC) method].
Prion Diseases
[Diagnosis of transmissible spongiform encephalopathies in Spain. Population perspective]
Prion Diseases
[Molecular interaction between PrP protein and the signal protein 14-3-3 beta]
Prion Diseases
[The basics of 14-3-3 protein family and research progress on therapeutic applications of 14-3-3 protein]
Prion Diseases
[Use and validity of the 14-3-3 protein test in the diagnosis of prion diseases: a 4-year prospective study]
Prolactinoma
PGAM5-CypD pathway is involved in bromocriptine-induced RIP3/MLKL-dependent necroptosis of prolactinoma cells.
Prostatic Hyperplasia
Activation of the mammalian target of rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics.
Prostatic Hyperplasia
Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases.
Prostatic Intraepithelial Neoplasia
Activation of the mammalian target of rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics.
Prostatic Intraepithelial Neoplasia
Functional analysis of the Aurora Kinase A Ile31 allelic variant in human prostate.
Prostatic Intraepithelial Neoplasia
Limited Significance of Activated Akt-Mammalian Target of Rapamycin Signaling Pathway in Prostate Cancer Progression.
Prostatic Neoplasms
14-3-3 Proteins Modulate the ETS Transcription Factor ETV1 in Prostate Cancer.
Prostatic Neoplasms
14-3-3sigma controls mitotic translation to facilitate cytokinesis.
Prostatic Neoplasms
2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.
Prostatic Neoplasms
3-Phosphoinositide-dependent protein kinase-1/Akt signalling and inhibition in a canine prostate carcinoma cell line.
Prostatic Neoplasms
4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management.
Prostatic Neoplasms
A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells.
Prostatic Neoplasms
A Hexane Fraction of Guava Leaves (Psidium guajava L.) Induces Anticancer Activity by Suppressing AKT/Mammalian Target of Rapamycin/Ribosomal p70 S6 Kinase in Human Prostate Cancer Cells.
Prostatic Neoplasms
A novel role for Wnt/Ca2+ signaling in actin cytoskeleton remodeling and cell motility in prostate cancer.
Prostatic Neoplasms
A Phase I/II Study of the Investigational Drug Alisertib in Combination With Abiraterone and Prednisone for Patients With Metastatic Castration-Resistant Prostate Cancer Progressing on Abiraterone.
Prostatic Neoplasms
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.
Prostatic Neoplasms
A randomized, double-blind, placebo-controlled, Phase II study with and without enzastaurin in combination with docetaxel-based chemotherapy in patients with castration-resistant metastatic prostate cancer.
Prostatic Neoplasms
A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NF?B and androgen receptor signaling in prostate cancer.
Prostatic Neoplasms
A-kinase interacting protein 1, a potential biomarker associated with advanced tumor features and CXCL1/2 in prostate cancer.
Prostatic Neoplasms
Aberrantly expressed long noncoding RNAs in recurrent implantation failure: A microarray related study.
Prostatic Neoplasms
Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate cancer cells through generation of reactive oxygen species and activation of c-Jun N-terminal kinase.
Prostatic Neoplasms
Activation of protein kinase CK2 attenuates FOXO3a functioning in a PML-dependent manner: implications in human prostate cancer.
Prostatic Neoplasms
Activation of the mammalian target of rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics.
Prostatic Neoplasms
Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions.
Prostatic Neoplasms
Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells.
Prostatic Neoplasms
Activation of the Wnt pathway through use of AR79, a glycogen synthase kinase 3beta inhibitor, promotes prostate cancer growth in soft tissue and bone.
Prostatic Neoplasms
Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity.
Prostatic Neoplasms
Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway.
Prostatic Neoplasms
Afzelin exhibits anti-cancer activity against androgen-sensitive LNCaP and androgen-independent PC-3 prostate cancer cells through the inhibition of LIM domain kinase 1.
Prostatic Neoplasms
AKT and cytosolic phospholipase A2? form a positive loop in prostate cancer cells.
Prostatic Neoplasms
Akt GSK-3 pathway as a target in genistein-induced inhibition of TRAMP prostate cancer progression toward a poorly differentiated phenotype.
Prostatic Neoplasms
AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.
Prostatic Neoplasms
Akt/survivin pathway inhibition enhances the apoptotic cell death-induced by alpha-santalol in human prostate cancer cells.
Prostatic Neoplasms
Altered expression of Akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue.
Prostatic Neoplasms
Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells.
Prostatic Neoplasms
AMP-activated protein kinase promotes human prostate cancer cell growth and survival.
Prostatic Neoplasms
Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway.
Prostatic Neoplasms
Analysis of complex protein kinase B signalling pathways in human prostate cancer samples.
Prostatic Neoplasms
Analysis of the expression and association of retinoblastoma binding protein 6 with the JNK signaling pathway in prostate cancers.
Prostatic Neoplasms
Androgen dependent regulation of protein kinase A subunits in prostate cancer cells.
Prostatic Neoplasms
Androgen deprivation therapy has no effect on Pim-1 expression in a mouse model of prostate cancer.
Prostatic Neoplasms
Androgen receptor activity at the prostate specific antigen locus: steroidal and non-steroidal mechanisms.
Prostatic Neoplasms
Androgen receptor levels are upregulated by Akt in prostate cancer.
Prostatic Neoplasms
Androgen suppresses protein kinase D1 expression through fibroblast growth factor receptor substrate 2 in prostate cancer cells.
Prostatic Neoplasms
Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2.
Prostatic Neoplasms
Anti-androgen receptor activity of apoptotic CK2 inhibitor CX4945 in human prostate cancer LNCap cells.
Prostatic Neoplasms
Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 ?/?-catenin pathway.
Prostatic Neoplasms
Antisense oligodeoxynucleotides targeting the serine/threonine kinase Pim-2 inhibited proliferation of DU-145 cells.
Prostatic Neoplasms
Artemisia kruhsiana leaf extract induces autophagic cell death in human prostate cancer cells.
Prostatic Neoplasms
ATM?JAK?PD?L1 signaling pathway inhibition decreases EMT and metastasis of androgen?independent prostate cancer.
Prostatic Neoplasms
Atorvastatin inhibited Rho-associated kinase 1 (ROCK1) and focal adhesion kinase (FAK) mediated adhesion and differentiation of CD133+CD44+ prostate cancer stem cells.
Prostatic Neoplasms
Attenuation of androgen receptor-dependent transcription by the serine/threonine kinase Pim-1.
Prostatic Neoplasms
Aurora A regulates expression of AR-V7 in models of castrate resistant prostate cancer.
Prostatic Neoplasms
Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.
Prostatic Neoplasms
Aurora-A regulates autophagy through the Akt pathway in human prostate cancer.
Prostatic Neoplasms
Beta-catenin mediates alteration in cell proliferation, motility and invasion of prostate cancer cells by differential expression of E-cadherin and protein kinase D1.
Prostatic Neoplasms
Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer.
Prostatic Neoplasms
Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.
Prostatic Neoplasms
Bioinformatics Based Therapeutic Effects of Sinomenium Acutum.
Prostatic Neoplasms
C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP.
Prostatic Neoplasms
Calcitonin increases tumorigenicity of prostate cancer cells: evidence for the role of protein kinase A and urokinase-type plasminogen receptor.
Prostatic Neoplasms
Calcitonin stimulates the secretion of urokinase-type plasminogen activator from prostate cancer cells: its possible implications on tumor cell invasion.
Prostatic Neoplasms
Calcium/Calmodulin-Dependent Kinase II Plays an Important Role in Prostate Cancer Cell Survival.
Prostatic Neoplasms
Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells.
Prostatic Neoplasms
CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.
Prostatic Neoplasms
Casein kinase 2 inhibition attenuates androgen receptor function and cell proliferation in prostate cancer cells.
Prostatic Neoplasms
Caveolin-1 Upregulation Contributes to c-Myc-Induced High-Grade Prostatic Intraepithelial Neoplasia and Prostate Cancer.
Prostatic Neoplasms
Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours.
Prostatic Neoplasms
Cell line modeling to study biomarker panel in prostate cancer.
Prostatic Neoplasms
Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer.
Prostatic Neoplasms
Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells.
Prostatic Neoplasms
Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells.
Prostatic Neoplasms
Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells.
Prostatic Neoplasms
CK2 Pro-Survival Role in Prostate Cancer Is Mediated via Maintenance and Promotion of Androgen Receptor and NF?B p65 Expression.
Prostatic Neoplasms
CK2-NCoR signaling cascade promotes prostate tumorigenesis.
Prostatic Neoplasms
Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
Prostatic Neoplasms
Curcumin attenuates ?-catenin signaling in prostate cancer cells through activation of protein kinase D1.
Prostatic Neoplasms
CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression.
Prostatic Neoplasms
CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12.
Prostatic Neoplasms
Cytoplasmic accumulation of glycogen synthase kinase-3beta is associated with aggressive clinicopathological features in human prostate cancer.
Prostatic Neoplasms
DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitor.
Prostatic Neoplasms
Defining and Targeting the Oncogenic Drivers of Neuroendocrine Prostate Cancer.
Prostatic Neoplasms
Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA.
Prostatic Neoplasms
Deregulation of FOXO3A during prostate cancer progression.
Prostatic Neoplasms
Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients.
Prostatic Neoplasms
Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells.
Prostatic Neoplasms
Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2.
Prostatic Neoplasms
Distinct expression and activity of GSK-3? and GSK-3? in prostate cancer.
Prostatic Neoplasms
DNA-PKcs Emerges as Master Driver of Metastasis.
Prostatic Neoplasms
DNA-PKcs Expression Is a Predictor of Biochemical Recurrence After Permanent Iodine 125 Interstitial Brachytherapy for Prostate Cancer.
Prostatic Neoplasms
DNA-PKcs Expression Predicts Response to Radiotherapy in Prostate Cancer.
Prostatic Neoplasms
Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer.
Prostatic Neoplasms
Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway.
Prostatic Neoplasms
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Prostatic Neoplasms
Effect of Ukrain on cell survival and apoptosis in the androgen-independent prostate cancer cell line PC-3.
Prostatic Neoplasms
Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer.
Prostatic Neoplasms
Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis.
Prostatic Neoplasms
Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells.
Prostatic Neoplasms
Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A.
Prostatic Neoplasms
Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines.
Prostatic Neoplasms
ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.
Prostatic Neoplasms
Expression and localisation of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients.
Prostatic Neoplasms
Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3{beta} phosphorylation.
Prostatic Neoplasms
Expression profiles of androgen independent bone metastatic prostate cancer cells indicate up-regulation of the putative serine-threonine kinase GS3955.
Prostatic Neoplasms
Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain.
Prostatic Neoplasms
Functional analysis of the Aurora Kinase A Ile31 allelic variant in human prostate.
Prostatic Neoplasms
Functional Loss of the gamma-catenin gene through epigenetic and genetic pathways in human prostate cancer.
Prostatic Neoplasms
G protein-coupled receptors provide survival signals in prostate cancer.
Prostatic Neoplasms
Gene fusion characterisation of rare aggressive prostate cancer variants-adenosquamous carcinoma, pleomorphic giant-cell carcinoma, and sarcomatoid carcinoma: an analysis of 19 cases.
Prostatic Neoplasms
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Prostatic Neoplasms
Genetic variants in RhoA and ROCK1 genes are associated with the development, progression and prognosis of prostate cancer.
Prostatic Neoplasms
Glycogen synthase kinase 3beta regulates cell death induced by synthetic triterpenoids.
Prostatic Neoplasms
Glycogen synthase kinase-3 beta is involved in the phosphorylation and suppression of androgen receptor activity.
Prostatic Neoplasms
Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis.
Prostatic Neoplasms
Glycogen synthase kinase-3 inhibitors suppress the AR-V7-mediated transcription and selectively inhibit cell growth in AR-V7-positive prostate cancer cells.
Prostatic Neoplasms
Glycogen synthase kinase-3: a potential preventive target for prostate cancer management.
Prostatic Neoplasms
Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer.
Prostatic Neoplasms
Glycogen synthase kinase-3beta suppression eliminates tumor necrosis factor-related apoptosis-inducing ligand resistance in prostate cancer.
Prostatic Neoplasms
Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells: role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways.
Prostatic Neoplasms
GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death.
Prostatic Neoplasms
Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling.
Prostatic Neoplasms
Heat shock protein 27 mediates repression of androgen receptor function by protein kinase D1 in prostate cancer cells.
Prostatic Neoplasms
High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence.
Prostatic Neoplasms
Hsa-miR-146a-5p modulates androgen-independent prostate cancer cells apoptosis by targeting ROCK1.
Prostatic Neoplasms
Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway.
Prostatic Neoplasms
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay.
Prostatic Neoplasms
Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells.
Prostatic Neoplasms
Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen.
Prostatic Neoplasms
Identification of natural allosteric inhibitor for Akt1 protein through computational approaches and in vitro evaluation.
Prostatic Neoplasms
Identification of simvastatin-regulated targets associated with JNK activation in DU145 human prostate cancer cell death signaling.
Prostatic Neoplasms
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
Prostatic Neoplasms
Imipramine Inhibits Migration and Invasion in Metastatic Castration-Resistant Prostate Cancer PC-3 Cells via AKT-Mediated NF-?B Signaling Pathway.
Prostatic Neoplasms
Impact of E6-associated protein on the proliferation and invasion of prostate cancer cells in bone metastasis.
Prostatic Neoplasms
Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells.
Prostatic Neoplasms
Increased Akt and phosphorylated Akt expression are associated with malignant biological features of prostate cancer in Japanese men.
Prostatic Neoplasms
Increased phospho-AKT is associated with loss of the androgen receptor during the progression of N-methyl-N-nitrosourea-induced prostate carcinogenesis in rats.
Prostatic Neoplasms
Independent role of phosphoinositol-3-kinase (PI3K) and casein kinase II (CK-2) in EGFR and Her-2-mediated constitutive NF-kappaB activation in prostate cancer cells.
Prostatic Neoplasms
Inecalcitol, an analog of 1?,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cells.
Prostatic Neoplasms
Inhibition of 5-lipoxygenase downregulates stemness and kills prostate cancer stem cells by triggering apoptosis via activation of c-Jun N-terminal kinase.
Prostatic Neoplasms
Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon.
Prostatic Neoplasms
Inhibition of Akt pathways in the treatment of prostate cancer.
Prostatic Neoplasms
Inhibition of apoptosis in prostate cancer cells by androgens is mediated through downregulation of c-Jun N-terminal kinase activation.
Prostatic Neoplasms
Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase.
Prostatic Neoplasms
Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells.
Prostatic Neoplasms
Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells.
Prostatic Neoplasms
Inhibition of glycogen synthase kinase-3 in androgen-responsive prostate cancer cell lines: are GSK inhibitors therapeutically useful?
Prostatic Neoplasms
Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth.
Prostatic Neoplasms
Inhibition of glycogen synthase kinase-3beta promotes nuclear export of the androgen receptor through a CRM1-dependent mechanism in prostate cancer cell lines.
Prostatic Neoplasms
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.
Prostatic Neoplasms
Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism.
Prostatic Neoplasms
Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism.
Prostatic Neoplasms
Inhibition of protein kinase CK2 leads to a modulation of androgen receptor dependent transcription in prostate cancer cells.
Prostatic Neoplasms
Inhibition of Protein Kinase CK2 Reduces Cyp24a1 Expression and Enhances 1,25-Dihydroxyvitamin D3 Antitumor Activity in Human Prostate Cancer Cells.
Prostatic Neoplasms
Inhibition of tumor growth and histopathological changes following treatment with a chemokine receptor CXCR4 antagonist in a prostate cancer xenograft model.
Prostatic Neoplasms
Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells.
Prostatic Neoplasms
Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells.
Prostatic Neoplasms
Investigational serine/threonine kinase inhibitors against prostate cancer metastases.
Prostatic Neoplasms
Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells.
Prostatic Neoplasms
JunD-mediated repression of GADD45? and ? regulates escape from cell death in prostate cancer.
Prostatic Neoplasms
KAT8 Regulates Androgen Signaling in Prostate Cancer Cells.
Prostatic Neoplasms
Killing two birds with one RKIP.
Prostatic Neoplasms
KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer.
Prostatic Neoplasms
Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.
Prostatic Neoplasms
Limited Significance of Activated Akt-Mammalian Target of Rapamycin Signaling Pathway in Prostate Cancer Progression.
Prostatic Neoplasms
Lithium suppresses cell proliferation by interrupting E2F-DNA interaction and subsequently reducing S-phase gene expression in prostate cancer.
Prostatic Neoplasms
Long noncoding RNA PANDAR promotes progression and predicts poor prognosis via upregulating ROCK1 in prostate cancer.
Prostatic Neoplasms
Loss of mir-146a function in hormone-refractory prostate cancer.
Prostatic Neoplasms
Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression.
Prostatic Neoplasms
Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer.
Prostatic Neoplasms
MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer.
Prostatic Neoplasms
Mechanism of ?-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3 ?-inactivated prostate cancer cells.
Prostatic Neoplasms
Mechanism of Androgen Receptor Corepression by CKBP2/CRIF1, a Multifunctional Transcription Factor Coregulator Expressed in Prostate Cancer.
Prostatic Neoplasms
Mechanisms of endocrine therapy-responsive and -unresponsive prostate tumours.
Prostatic Neoplasms
MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease.
Prostatic Neoplasms
Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance.
Prostatic Neoplasms
Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer.
Prostatic Neoplasms
Metastasis suppressor genes: a role for raf kinase inhibitor protein (RKIP).
Prostatic Neoplasms
Metformin sensitizes prostate cancer cells to radiation through EGFR/p-DNA-PKCS in vitro and in vivo.
Prostatic Neoplasms
MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells.
Prostatic Neoplasms
MicroRNA181c inhibits prostate cancer cell growth and invasion by targeting multiple ERK signaling pathway components.
Prostatic Neoplasms
Microsecond molecular dynamics simulations and dynamic network analysis provide understanding of the allosteric inactivation of GSK3? induced by the L343R mutation.
Prostatic Neoplasms
miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer.
Prostatic Neoplasms
miR-31-5p Regulates 14-3-3 ? to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway.
Prostatic Neoplasms
MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP.
Prostatic Neoplasms
Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells.
Prostatic Neoplasms
Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models.
Prostatic Neoplasms
Neuroendocrine cells in prostate cancer.
Prostatic Neoplasms
New Pyrazolopyrimidine Inhibitors of Protein Kinase D as Potent Anticancer Agents for Prostate Cancer Cells.
Prostatic Neoplasms
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.
Prostatic Neoplasms
Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility.
Prostatic Neoplasms
Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer.
Prostatic Neoplasms
Nuclear matrix targeting of the protein kinase CK2 signal as a common downstream response to androgen or growth factor stimulation of prostate cancer cells.
Prostatic Neoplasms
Observed correlation between the expression levels of catalytic subunit, C?2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness.
Prostatic Neoplasms
Oral enzastaurin in prostate cancer: A two-cohort phase II trial in patients with PSA progression in the non-metastatic castrate state and following docetaxel-based chemotherapy for castrate metastatic disease.
Prostatic Neoplasms
Overexpression of ecto-protein kinases in prostasomes of metastatic cell origin.
Prostatic Neoplasms
Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3'-kinase pathway.
Prostatic Neoplasms
Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer.
Prostatic Neoplasms
Overview of Protein Kinase B Enzyme:a Potential Target for breast and Prostate Cancer.
Prostatic Neoplasms
P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor ? expression and enhanced matrix metalloproteinase 9 secretion.
Prostatic Neoplasms
p21-Activated kinase 4 promotes prostate cancer progression through CREB.
Prostatic Neoplasms
PEBP4 silencing inhibits hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells.
Prostatic Neoplasms
Perifosine induces differentiation and cell death in prostate cancer cells.
Prostatic Neoplasms
Pharmacological exploitation of the alpha1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation.
Prostatic Neoplasms
Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth factor-beta pathways in prostate cancer.
Prostatic Neoplasms
Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival.
Prostatic Neoplasms
Pim family kinases enhance tumor growth of prostate cancer cells.
Prostatic Neoplasms
Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.
Prostatic Neoplasms
Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer.
Prostatic Neoplasms
PIM1 Kinase as a Target in Prostate Cancer: Roles in Tumorigenesis, Castration Resistance, and Docetaxel Resistance.
Prostatic Neoplasms
Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3K? inhibitors.
Prostatic Neoplasms
Presence of chromogranins and regulation of their synthesis and processing in a neuroendocrine prostate tumor cell line.
Prostatic Neoplasms
Prevention of Prostate Cancer with Oleanane Synthetic Triterpenoid CDDO-Me in the TRAMP Mouse Model of Prostate Cancer.
Prostatic Neoplasms
PRKAR2B-HIF-1? loop promotes aerobic glycolysis and tumour growth in prostate cancer.
Prostatic Neoplasms
Prognostic Value of Akt-1 in Human Prostate Cancer: A Computerized Quantitative Assessment with Quantum Dot Technology.
Prostatic Neoplasms
Prostaglandin E2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells.
Prostatic Neoplasms
Prostaglandin E2 stimulates S100A8 expression by activating protein kinase A and CCAAT/enhancer-binding-protein-beta in prostate cancer cells.
Prostatic Neoplasms
Prostate cancer cell proliferation is influenced by leptin.
Prostatic Neoplasms
Protein kinase A (PKA) pathway is functionally linked to androgen receptor (AR) in the progression of prostate cancer.
Prostatic Neoplasms
Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration.
Prostatic Neoplasms
Protein Kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cells.
Prostatic Neoplasms
Protein kinase A RI-alpha predicts for prostate cancer outcome: analysis of radiation therapy oncology group trial 86-10.
Prostatic Neoplasms
Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation.
Prostatic Neoplasms
Protein kinase A type II-? regulatory subunit regulates the response of prostate cancer cells to taxane treatment.
Prostatic Neoplasms
Protein kinase CK2 impact on intracellular calcium homeostasis in prostate cancer.
Prostatic Neoplasms
Protein kinase CK2 is involved in zinc homeostasis in breast and prostate cancer cells.
Prostatic Neoplasms
Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells.
Prostatic Neoplasms
Protein kinase D1 (PKD1) influences androgen receptor (AR) function in prostate cancer cells.
Prostatic Neoplasms
Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer.
Prostatic Neoplasms
Protein kinase D1-mediated phosphorylation and subcellular localization of beta-catenin.
Prostatic Neoplasms
Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.
Prostatic Neoplasms
Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy.
Prostatic Neoplasms
Proteomic identification of 14-3-3 sigma as a common component of the androgen receptor and the epidermal growth factor receptor signaling pathways of the human prostate epithelial cell line M12.
Prostatic Neoplasms
PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer.
Prostatic Neoplasms
PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer.
Prostatic Neoplasms
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.
Prostatic Neoplasms
Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3).
Prostatic Neoplasms
Raf Kinase Inhibitor Protein (RKIP) Blocks Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Breast and Prostate Cancer.
Prostatic Neoplasms
Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer.
Prostatic Neoplasms
Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene.
Prostatic Neoplasms
Raf-1 expression may influence progression to androgen insensitive prostate cancer.
Prostatic Neoplasms
Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound.
Prostatic Neoplasms
Reactive oxygen species-dependent apoptosis by gugulipid extract of Ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase.
Prostatic Neoplasms
Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.
Prostatic Neoplasms
Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases.
Prostatic Neoplasms
Reduced pim-1 expression increases chemotherapeutic drug sensitivity in human androgen-independent prostate cancer cells by inducing apoptosis.
Prostatic Neoplasms
Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells.
Prostatic Neoplasms
Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway.
Prostatic Neoplasms
Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.
Prostatic Neoplasms
Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells.
Prostatic Neoplasms
Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer.
Prostatic Neoplasms
Retraction: Raf Kinase Inhibitor Protein (RKIP) Blocks Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Breast and Prostate Cancer.
Prostatic Neoplasms
Rho-Associated Protein Kinase (ROCK) Promotes Proliferation and Migration of PC-3 and DU145 Prostate Cancer Cells by Targeting LIM Kinase 1 (LIMK1) and Matrix Metalloproteinase-2 (MMP-2).
Prostatic Neoplasms
RhoB enhances migration and MMP1 expression of prostate cancer DU145.
Prostatic Neoplasms
RhoBTB1 interacts with ROCKs and inhibits invasion.
Prostatic Neoplasms
RKIp inhibits the migration and invasion of human prostate cancer PC-3M cells through regulation of extracellular matrix.
Prostatic Neoplasms
RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells.
Prostatic Neoplasms
Role of protein kinase CK2 in the regulation of tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis in prostate cancer cells.
Prostatic Neoplasms
Role of Raf Kinase Inhibitor Protein in Pathophysiology of Prostate Cancer.
Prostatic Neoplasms
ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells.
Prostatic Neoplasms
Sanggenol L Induces Apoptosis and Cell Cycle Arrest via Activation of p53 and Suppression of PI3K/Akt/mTOR Signaling in Human Prostate Cancer Cells.
Prostatic Neoplasms
Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer.
Prostatic Neoplasms
SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest.
Prostatic Neoplasms
Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells.
Prostatic Neoplasms
SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1.
Prostatic Neoplasms
Sichuan Pepper Extracts Block the PAK1/Cyclin D1 Pathway and the Growth of NF1-Deficient Cancer Xenograft in Mice.
Prostatic Neoplasms
SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells.
Prostatic Neoplasms
Structure-based assessment and network analysis of targeting 14-3-3 proteins in prostate cancer.
Prostatic Neoplasms
Suppression of BCL2 by Antisense Oligonucleotides and Compensation by Non-Targeted Genes May Enhance Tumor Proliferation.
Prostatic Neoplasms
Suppression of casein kinase 2 sensitizes tumor cells to antitumor TRAIL therapy by regulating the phosphorylation and localization of p65 in prostate cancer.
Prostatic Neoplasms
Suppression of glycogen synthase kinase 3 activity reduces tumor growth of prostate cancer in vivo.
Prostatic Neoplasms
Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells.
Prostatic Neoplasms
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
Prostatic Neoplasms
Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer.
Prostatic Neoplasms
Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo.
Prostatic Neoplasms
Testosterone, sex hormone-binding globulin, and body composition in young adult African American and Caucasian men.
Prostatic Neoplasms
TF - A novel cell-permeable and selective inhibitor of human protein kinase CK2 induces apoptosis in the prostate cancer cell line LNCaP.
Prostatic Neoplasms
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.
Prostatic Neoplasms
The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein.
Prostatic Neoplasms
The Effects and Mechanism of YK-4-279 in Combination with Docetaxel on Prostate Cancer.
Prostatic Neoplasms
The importance of protein kinase A in prostate cancer: relationship to patient outcome in Radiation Therapy Oncology Group trial 92-02.
Prostatic Neoplasms
The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer.
Prostatic Neoplasms
The molecular mechanism of Vav3 oncogene on upregulation of androgen receptor activity in prostate cancer cells.
Prostatic Neoplasms
The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer.
Prostatic Neoplasms
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling.
Prostatic Neoplasms
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models.
Prostatic Neoplasms
The Role of the Calcitonin Peptide Family in Prostate Cancer and Bone Metastasis.
Prostatic Neoplasms
The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance.
Prostatic Neoplasms
The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation.
Prostatic Neoplasms
Therapeutic efficacy of curcumin/TRAIL combination regimen for hormone-refractory prostate cancer.
Prostatic Neoplasms
Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.
Prostatic Neoplasms
Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells.
Prostatic Neoplasms
Tissue transglutaminase interacts with protein kinase A anchor protein 13 in prostate cancer.
Prostatic Neoplasms
Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).
Prostatic Neoplasms
Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins.
Prostatic Neoplasms
Transcriptional regulation of PRKAR2B by miR-200b-3p/200c-3p and XBP1 in human prostate cancer.
Prostatic Neoplasms
Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes.
Prostatic Neoplasms
Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase.
Prostatic Neoplasms
UNC5D, suppressed by promoter hypermethylation, inhibits cell metastasis by activating death-associated protein kinase 1 in prostate cancer.
Prostatic Neoplasms
Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer.
Prostatic Neoplasms
Up-regulation of LIMK1 expression in prostate cancer is correlated with poor pathological features, lymph node metastases and biochemical recurrence.
Prostatic Neoplasms
Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma.
Prostatic Neoplasms
Vascular endothelial growth factor-C protects prostate cancer cells from oxidative stress by the activation of mammalian target of rapamycin complex-2 and AKT-1.
Prostatic Neoplasms
Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKC? without inhibiting Akt.
Prostatic Neoplasms
Zinc and p53 disrupt mitochondrial binding of HK2 by phosphorylating VDAC1.
Prostatic Neoplasms
[Both CK2 catalytic subunits involves in androgen receptor signaling in prostate cancer cells].
Prostatic Neoplasms
[Citron Rho-interacting serine/threonine kinase knockdown suppresses prostate cancer cell proliferation and metastasis by blocking Hippo-YAP pathway].
Prostatic Neoplasms
[Effect of Aurora A on biological phenotypes of prostate cancer cells]
Prostatic Neoplasms
[Effect of aurora A on carcinogenesis of human prostate cancer]
Prostatic Neoplasms
[Expression of Raf kinase inhibitor protein and E-cadherin in prostate cancer tissues.]
Prostatic Neoplasms
[Study on the relationship between Aurora A expression in cancer cell and treatment efficacy of taxol for prostate cancer]
Prostatic Neoplasms
{beta}2-Microglobulin Is a Signaling and Growth-Promoting Factor for Human Prostate Cancer Bone Metastasis.
protein acetyllysine n-acetyltransferase deficiency
Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation.
protein acetyllysine n-acetyltransferase deficiency
Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction.
protein-tyrosine-phosphatase deficiency
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.
protein-tyrosine-phosphatase deficiency
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
Proteinuria
A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.
Proteinuria
Curcumin protects against fructose-induced podocyte insulin signaling impairment through upregulation of miR-206.
Proteinuria
Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice.
Proteinuria
Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathway.
Proteinuria
Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.
Pseudohypoaldosteronism
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo.
Pseudohypoaldosteronism
A novel protein kinase signaling pathway essential for blood pressure regulation in humans.
Pseudohypoaldosteronism
Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
Pseudohypoaldosteronism
Dietary salt modulates the sodium chloride cotransporter expression likely through an aldosterone-mediated WNK4-ERK1/2 signaling pathway.
Pseudohypoaldosteronism
Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
Pseudohypoaldosteronism
Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF.
Pseudohypoaldosteronism
Monogenic forms of human hypertension.
Pseudohypoaldosteronism
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform.
Pseudohypoaldosteronism
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.
Pseudohypoaldosteronism
Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.
Pseudohypoaldosteronism
The molecular basis of hypertension.
Pseudohypoaldosteronism
Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.
Pseudohypoaldosteronism
WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.
Pseudohypoparathyroidism
Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance.
Pseudorabies
A major phosphoprotein of cells infected with pseudorabies virus is phosphorylated by cellular casein kinase II.
Pseudorabies
Activation of a ribosomal protein S6 kinase in mouse fibroblasts during infection with herpesvirus.
Pseudorabies
Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1.
Pseudorabies
Role of pseudorabies virus Us3 protein kinase during neuronal infection.
Pseudorabies
The Pseudorabies Virus Encoded Serine/Threonine Kinase Us3 and Viral Egress.
Pseudorabies
The pseudorabies virus serine/threonine kinase Us3 contains mitochondrial, nuclear and membrane localization signals.
Psoriasis
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Psoriasis
A highly decreased binding of cyclic adenosine monophosphate to protein kinase A in erythrocyte membranes is specific for active psoriasis.
Psoriasis
A study on altered expression of serine palmitoyltransferase and ceramidase in psoriatic skin lesion.
Psoriasis
c-Jun N-terminal kinase (JNK)-phospho-c-JUN (ser63/73) pathway is essential for FOXP3 nuclear translocation in psoriasis.
Psoriasis
Casein kinase III activity in psoriasis.
Psoriasis
Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages.
Psoriasis
Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and its Pharmacokinetic Application.
Psoriasis
Inhibiting Glycogen Synthase Kinase-3 Decreases 12-O-Tetradecanoylphorbol-13-Acetate-Induced Interferon-?-Mediated Skin Inflammation.
Psoriasis
Integrative biology approach identifies cytokine targeting strategies for psoriasis.
Psoriasis
Lithium regulates keratinocyte proliferation via glycogen synthase kinase 3 and NFAT2 (nuclear factor of activated T cells 2).
Psoriasis
LncRNA RP6-65G23.1 accelerates proliferation and inhibits apoptosis via p-ERK1/2/p-AKT signaling pathway on keratinocytes.
Psoriasis
MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40.
Psoriasis
Protein kinase D distribution in normal human epidermis, basal cell carcinoma and psoriasis.
Psoriasis
Sorafenib-associated remission of psoriasis in hypernephroma: case report.
Psoriasis
Sortilin regulates keratinocyte proliferation and apoptosis through the PI3K-AKT signaling pathway.
Psoriasis
The role of p38 MAPK in the aetiopathogenesis of psoriasis and psoriatic arthritis.
Psychomotor Agitation
Region-specific inhibition of 14-3-3 proteins induces psychomotor behaviors in mice.
Pterygium
The role of RIPK4 in epidermis physiology
Puberty, Precocious
Buserelin Inhibits the Immunosuppressive Activity of Regulatory T Cells through the Protein Kinase A Signaling in a Central Precocious Puberty Model.
Pulmonary Arterial Hypertension
Ataxia-Telangiectasia Mutated (ATM) Protein Signaling Participates in Development of Pulmonary Arterial Hypertension in Rats.
Pulmonary Arterial Hypertension
Baicalin prevents pulmonary arterial remodeling in vivo via the AKT/ERK/NF-?B signaling pathways.
Pulmonary Arterial Hypertension
Checkpoint Kinase 1 Promotes the Development of Pulmonary Arterial Hypertension.
Pulmonary Arterial Hypertension
High glucose promotes vascular smooth muscle cell proliferation by upregulating proto-oncogene serine/threonine-protein kinase Pim-1 expression.
Pulmonary Arterial Hypertension
Sequencing of mutations in the serine/threonine kinase domain of the bone morphogenetic protein receptor type 2 gene causing pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Atrophy and hypertrophy signalling of the quadriceps and diaphragm in COPD.
Pulmonary Disease, Chronic Obstructive
Bufei Yishen Granules Combined with Acupoint Sticking Therapy Suppress Inflammation in Chronic Obstructive Pulmonary Disease Rats: Via JNK/p38 Signaling Pathway.
Pulmonary Disease, Chronic Obstructive
Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease (COPD).
Pulmonary Disease, Chronic Obstructive
Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients.
Pulmonary Disease, Chronic Obstructive
Glycogen synthase kinase-3 (GSK-3) regulates TGF-?(1) -induced differentiation of pulmonary fibroblasts.
Pulmonary Disease, Chronic Obstructive
Glycogen Synthase Kinase-3 regulates Cigarette Smoke Extract- and IL-1{beta}-Induced Cytokine Secretion by Airway Smooth Muscle.
Pulmonary Disease, Chronic Obstructive
Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation.
Pulmonary Disease, Chronic Obstructive
Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pulmonary Disease, Chronic Obstructive
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Pulmonary Disease, Chronic Obstructive
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Pulmonary Disease, Chronic Obstructive
Reduced expression of growth differentiation factor 11 promoted the progression of chronic obstructive pulmonary disease by activating the AKT signaling pathway.
Pulmonary Disease, Chronic Obstructive
Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin.
Pulmonary Disease, Chronic Obstructive
The PI3K/AKT/mTOR pathway regulates autophagy to induce apoptosis of alveolar epithelial cells in chronic obstructive pulmonary disease caused by PM2.5 particulate matter.
Pulmonary Disease, Chronic Obstructive
Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer.
Pulmonary Edema
Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury.
Pulmonary Edema
ROCK2 and MYLK variants under hypobaric hypoxic environment of high altitude associate with high altitude pulmonary edema and adaptation.
Pulmonary Fibrosis
3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
Pulmonary Fibrosis
Buyang Huanwu Decoction Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats via Downregulation of Related Protein and Gene Expression.
Pulmonary Fibrosis
CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis.
Pulmonary Fibrosis
Casein Kinase 1?/? Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-? in Pulmonary Fibrosis.
Pulmonary Fibrosis
Clinical significance of mTOR, ZEB1, ROCK1 expression in lung tissues of pulmonary fibrosis patients.
Pulmonary Fibrosis
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Pulmonary Fibrosis
Function of the transforming growth factor-?1/c-Jun N-terminal kinase signaling pathway in the action of thalidomide on a rat model of pulmonary fibrosis.
Pulmonary Fibrosis
LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis.
Pulmonary Fibrosis
The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.
Pure Autonomic Failure
Autonomic dysfunction in genetic forms of synucleinopathies.
pyruvate dehydrogenase (acetyl-transferring) deficiency
Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect.
Pyruvate Dehydrogenase Complex Deficiency Disease
Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect.
Rabies
1H, 13C and 15N resonance assignments of the PDZ of microtubule-associated serine/threonine kinase 205 (MAST205) in complex with the C-terminal motif from the rabies virus glycoprotein.
Rabies
Rabies virus nucleoprotein is phosphorylated by cellular casein kinase II.
Rabies
Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth.
Rabies
The Serine/Threonine Kinase AP2-Associated Kinase 1 Plays an Important Role in Rabies Virus Entry.
Radiation Pneumonitis
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy.
receptor protein serine/threonine kinase deficiency
RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation.
Rectal Neoplasms
CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.
Rectal Neoplasms
Comparative mutational analysis of distal colon cancer with rectal cancer.
Rectal Neoplasms
Complete Pathologic Response of Multiple Liver Metastases and Clinical Complete Response of Rectal Cancer in a Patient with Ataxia-Telangiectasia Mutated Gene Mutations After XELOXIRI Plus Bevacizumab: A Case Report.
Rectal Neoplasms
Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer.
Rectal Neoplasms
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Rectal Neoplasms
MicroRNA?144 inhibits migration and proliferation in rectal cancer by downregulating ROCK?1.
Rectal Neoplasms
Synergistic effects of AKAP95, Cyclin D1, Cyclin E1, and Cx43 in the development of rectal cancer.
REM Sleep Behavior Disorder
Absence of LRRK2 mutations in a cohort of patients with idiopathic REM sleep behavior disorder.
REM Sleep Behavior Disorder
Cognition among individuals along a spectrum of increased risk for Parkinson's disease.
REM Sleep Behavior Disorder
LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder.
REM Sleep Behavior Disorder
REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers.
REM Sleep Behavior Disorder
Sleep aspects on video-polysomnography in LRRK2 mutation carriers.
Renal Insufficiency
Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
Renal Insufficiency
Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney.
Renal Insufficiency, Chronic
Estradiol reverses TGF-beta1-induced mesangial cell apoptosis by a casein kinase 2-dependent mechanism.
Renal Insufficiency, Chronic
No associations between rs2030712 and rs7456421 single nucleotide polymorphisms of HIPK2 gene and prevalence of chronic kidney disease. Results of a family-based study.
Renal Insufficiency, Chronic
Redox and Activation of Protein Kinase A Dysregulates Calcium Homeostasis in Pulmonary Vein Cardiomyocytes of Chronic Kidney Disease.
Renal Insufficiency, Chronic
Renoprotective Effects of a Novel Receptor-Interacting Protein Kinase 2 Inhibitor, AS3334034, in Uninephrectomized Adriamycin-Induced Chronic Kidney Disease Rats.
Renal Insufficiency, Chronic
RIPK3 blockade attenuates kidney fibrosis in a folic acid model of renal injury.
Renal Insufficiency, Chronic
The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk.
Renal Insufficiency, Chronic
Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma.
Reoviridae Infections
Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun.
Reperfusion Injury
A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice.
Reperfusion Injury
A Rho-associated kinase mitigates reperfusion-induced change in the shape of cardiac capillary endothelial cells in situ.
Reperfusion Injury
Alamandine protects rat from myocardial ischemia-reperfusion injury by activating JNK and inhibiting NF-?B.
Reperfusion Injury
Attenuation of ischemia-reperfusion injury by sevoflurane postconditioning involves protein kinase B and glycogen synthase kinase 3 beta activation in isolated rat hearts.
Reperfusion Injury
Berberine inhibits the ischemia-reperfusion injury induced inflammatory response and apoptosis of myocardial cells through the phosphoinositide 3-kinase/RAC-? serine/threonine-protein kinase and nuclear factor-?B signaling pathways.
Reperfusion Injury
Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS.
Reperfusion Injury
Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3beta.
Reperfusion Injury
Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by Inhibitor 1 of Protein Phosphatase 1 Protects Against Myocardial Ischemia-Reperfusion Injury.
Reperfusion Injury
CaMKII determines mitochondrial stress responses in heart.
Reperfusion Injury
CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.
Reperfusion Injury
CaMKII: The molecular villain that aggravates cardiovascular disease.
Reperfusion Injury
CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1.
Reperfusion Injury
Cardioprotection against reperfusion injury: updated mechanisms and strategies.
Reperfusion Injury
Cardioprotection by post-conditioning with exogenous triiodothyronine in isolated perfused rat hearts and isolated adult rat cardiomyocytes.
Reperfusion Injury
Cardioprotective effect of melatonin against ischaemia/reperfusion damage.
Reperfusion Injury
Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore.
Reperfusion Injury
Death-associated Protein Kinase 1 Regulates Oxidative Stress In Cardiac Ischemia Reperfusion Injury.
Reperfusion Injury
Denitrosylation of nNOS induced by cerebral ischemia-reperfusion contributes to nitrosylation of CaMKII and its inhibition of autophosphorylation in hippocampal CA1.
Reperfusion Injury
DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis.
Reperfusion Injury
Effect of hydrogen sulfide on cardiomyocyte apoptosis in rats with myocardial ischemia-reperfusion injury via the JNK signaling pathway.
Reperfusion Injury
Effect of sevoflurane on the ATPase activity of hippocampal neurons in a rat model of cerebral ischemia-reperfusion injury via the cAMP-PKA signaling pathway.
Reperfusion Injury
Effect of ulinastatin on myocardial ischemia-reperfusion injury through JNK and P38 MAPK signaling pathways.
Reperfusion Injury
Effects and Mechanism of Action of Inducible Nitric Oxide Synthase on Apoptosis in a Rat Model of Cerebral Ischemia-Reperfusion Injury.
Reperfusion Injury
Effects of SP600125 and hypothermic machine perfusion on livers donated after cardiac death in a pig allograft transplantation model.
Reperfusion Injury
Essential role for smooth muscle cell stromal interaction molecule-1 in myocardial infarction.
Reperfusion Injury
Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3beta.
Reperfusion Injury
Glycogen synthase kinase 3 inhibition protects the heart from acute ischemia-reperfusion injury via inhibition of inflammation and apoptosis.
Reperfusion Injury
HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1.
Reperfusion Injury
Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.
Reperfusion Injury
Identification of Tpr and ?-actinin-4 as two novel SLK-interacting proteins.
Reperfusion Injury
Increased expression of IRE1alpha and stress-related signal transduction proteins in ischemia-reperfusion injured retina.
Reperfusion Injury
Infarct-remodeled myocardium is receptive to protection by isoflurane postconditioning: role of protein kinase B/Akt signaling.
Reperfusion Injury
Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8.
Reperfusion Injury
Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury.
Reperfusion Injury
Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism.
Reperfusion Injury
Inhibition of GSK-3beta ameliorates hepatic ischemia-reperfusion injury through GSK-3beta/beta-catenin signaling pathway in mice.
Reperfusion Injury
Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3beta.
Reperfusion Injury
Isoform- and Cell Type-Specific Roles of Glycogen Synthase Kinase 3 N-Terminal Serine Phosphorylation in Liver Ischemia Reperfusion Injury.
Reperfusion Injury
JNK inhibition alleviates oxidative DNA damage, germ cell apoptosis, and mitochondrial dysfunction in testicular ischemia reperfusion injury.
Reperfusion Injury
Lipid peroxidation activates mitogen-activated protein kinases in testicular ischemia-reperfusion injury.
Reperfusion Injury
Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury.
Reperfusion Injury
Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3beta and mitochondrial permeability transition pore.
Reperfusion Injury
MiR-181a affects myocardial ischemia-reperfusion injury in rats via regulating akt signaling pathway.
Reperfusion Injury
Myocardial reperfusion injury management: Erythropoietin compared with postconditioning.
Reperfusion Injury
Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity.
Reperfusion Injury
Optimized postconditioning algorithm protects liver graft after liver transplantation in rats.
Reperfusion Injury
Oxidation of Protein Kinase A Regulatory Subunit PKARI? Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release.
Reperfusion Injury
p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.
Reperfusion Injury
Past and present course of cardioprotection against ischemia-reperfusion injury.
Reperfusion Injury
Pharmacologic therapeutics for cardiac reperfusion injury.
Reperfusion Injury
PKC? and PKC? are Differentially Activated and Modulate Neurotoxic Signaling Pathways During Oxygen Glucose Deprivation in Rat Cortical Slices.
Reperfusion Injury
Protective effect of urantide against ischemia-reperfusion injury via protein kinase C and phosphtidylinositol 3'-kinase - Akt pathway.
Reperfusion Injury
Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies.
Reperfusion Injury
Protein kinase A-mediated cardioprotection of Tongxinluo relates to the inhibition of myocardial inflammation, apoptosis, and edema in reperfused swine hearts.
Reperfusion Injury
Protein Kinase B (PKB/AKT1) Formed Signaling Complexes with Mitochondrial Proteins and Prevented Glycolytic Energy Dysfunction in Cultured Cardiomyocytes During Ischemia-Reperfusion Injury.
Reperfusion Injury
Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)-Mixed Lineage Kinase Domain-Like Protein (MLKL)-Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers.
Reperfusion Injury
Remote ischemic preconditioning does not induce activation of Akt and STAT5 in the rat heart.
Reperfusion Injury
Research on mechanism of sevoflurane in alleviating cerebral ischemia-reperfusion injury in rats through JNK signaling pathway.
Reperfusion Injury
Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo: [Le role des Erk1/2, p70s6K et eNOS dans la cardioprotection induite par l'isoflurane pendant la reperfusion in vivo precoce].
Reperfusion Injury
Roles of MAPKAPK-2 and HSP27 in the reduction of renal ischemia-reperfusion injury by ischemic postconditioning in rats.
Reperfusion Injury
Salvianolate increases heat shock protein expression in a cerebral ischemia-reperfusion injury model.
Reperfusion Injury
Sevoflurane protects against ischemia-reperfusion injury in mice after total knee arthroplasty via facilitating RASD1-mediated protein kinase A pathway activation.
Reperfusion Injury
STAT3? interacts with nuclear GSK3beta and cytoplasmic RISK pathway and stabilizes rhythm in the anoxic-reoxygenated embryonic heart.
Reperfusion Injury
Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
Reperfusion Injury
The protective effects of CHIR99021 against oxidative injury in LO2 cells.
Reperfusion Injury
The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury.
Reperfusion Injury
Transforming growth-beta 1 contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury by regulating the c-Jun N-terminal kinase signaling pathway.
Reperfusion Injury
Tubular mitochondrial AKT1 is activated during ischemia reperfusion injury and has a critical role in predisposition to chronic kidney disease.
Reperfusion Injury
[Ischemic preconditioning attenuates myocardial no-reflow and reperfusion injury after revascularization of acute myocardial infarction by reducing myocardial edema via the protein kinase A pathway].
Reperfusion Injury
[Na+/Ca2+ exchanger mediates ischemia-reperfusion injury by activation of CaMKII in isolated rat heart].
Reperfusion Injury
[Protective role of PTEN inhibition against liver ischemia-reperfusion injury in mice and its underlying mechanisms].
Respiratory Distress Syndrome
Activation of death-associated protein kinase 1 promotes neutrophil apoptosis to accelerate inflammatory resolution in acute respiratory distress syndrome.
Respiratory Distress Syndrome
Inhibition of c-Jun N-terminal Kinase Signaling Pathway Alleviates Lipopolysaccharide-induced Acute Respiratory Distress Syndrome in Rats.
Respiratory Insufficiency
Effect of Tamoxifen and Brain-Penetrant Protein Kinase C and c-Jun N-Terminal Kinase Inhibitors on Tolerance to Opioid-Induced Respiratory Depression in Mice.
Respiratory Insufficiency
Inhibition of protein kinase A and GIRK channel reverses fentanyl-induced respiratory depression.
Respiratory Insufficiency
Phenotypic Effects of Homeodomain-Interacting Protein Kinase 2 Deletion in Mice.
Restless Legs Syndrome
A case of restless leg syndrome in a family with LRRK2 gene mutation.
Retinal Degeneration
A Drosophila model for LRRK2-linked parkinsonism.
Retinal Degeneration
Exploring Excitotoxicity and Regulation of a Constitutively Active TRP Ca2+ Channel in Drosophila.
Retinal Degeneration
Expression of Wild-Type Rp1 Protein in Rp1 Knock-in Mice Rescues the Retinal Degeneration Phenotype.
Retinal Degeneration
GSK-3 Inhibitors: From the Brain to the Retina and Back Again.
Retinal Degeneration
Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen.
Retinal Degeneration
Leucine-rich repeat kinase interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.
Retinal Degeneration
Loss of Raf-1 kinase inhibitory protein delays early-onset severe retinal ciliopathy in Cep290rd16 mouse.
Retinal Degeneration
Role of rhodopsin and arrestin phosphorylation in retinal degeneration of Drosophila.
Retinal Degeneration
The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss.
Retinal Detachment
Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress.
Retinal Detachment
Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.
Retinal Neovascularization
Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina.
Retinal Neovascularization
Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites.
Retinal Neovascularization
Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization.
Retinal Neovascularization
The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt-VEGF signaling pathway.
Retinal Neovascularization
The role of Raf-1 kinase in diabetic retinopathy.
Retinitis
Antisense therapy in oncology: new hope for an old idea?
Retinitis Pigmentosa
A novel missense RP1 mutation in retinitis pigmentosa.
Retinitis Pigmentosa
Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen.
Retinitis Pigmentosa
Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation.
Retinitis Pigmentosa
Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa.
Retinitis Pigmentosa
Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa.
Retinitis Pigmentosa
Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis).
Retinitis Pigmentosa
Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa.
Retinitis Pigmentosa
Three novel and the common Arg677Ter RP1 protein truncating mutations causing autosomal dominant retinitis pigmentosa in a Spanish population.
Retinoblastoma
7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d] pyrimidin-4-ylamine inhibits the proliferation and migration of vascular smooth muscle cells by suppressing ERK and Akt pathways.
Retinoblastoma
Aberrant CpG island hypermethylation profile is associated with atypical and anaplastic meningiomas.
Retinoblastoma
Analysis of the expression and association of retinoblastoma binding protein 6 with the JNK signaling pathway in prostate cancers.
Retinoblastoma
Arterialization of a vein graft promotes cell cycle progression through Akt and p38 mitogen-activated protein kinase pathways: impact of the preparation procedure.
Retinoblastoma
c-Jun N-terminal kinase is involved in the regulation of proliferation and apoptosis by integrin-linked kinase in human retinoblastoma cells.
Retinoblastoma
CB2R induces a protective response for epileptic seizure via the PI3K 110?-AKT signaling pathway.
Retinoblastoma
CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells.
Retinoblastoma
Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblastoma by regulating ROCK1 expression.
Retinoblastoma
Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas.
Retinoblastoma
Co-purification of p34cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein.
Retinoblastoma
Cooperative cell-growth inhibition by combination treatment with ZD1839 (Iressa) and trastuzumab (Herceptin) in non-small-cell lung cancer.
Retinoblastoma
Differential regulation of the synthesis and activity of the major cyclin-dependent kinases, p34cdc2, p33cdk2, and p34cdk4, during cell cycle entry and progression in normal human T lymphocytes.
Retinoblastoma
Disrupting the interaction between retinoblastoma protein and Raf-1 leads to defects in progenitor cell proliferation and survival during early inner ear development.
Retinoblastoma
DNA damage checkpoints in stem cells, ageing and cancer.
Retinoblastoma
DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology.
Retinoblastoma
GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling.
Retinoblastoma
Glycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cells.
Retinoblastoma
GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation.
Retinoblastoma
Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1.
Retinoblastoma
GSK-3/beta-catenin signaling axis in airway smooth muscle: role in mitogenic signaling.
Retinoblastoma
In vivo analysis reveals different apoptotic pathways in pre- and postmigratory cerebellar granule cells of rabbit.
Retinoblastoma
Involvement of glycogen synthase kinase-3beta signaling and aberrant nucleocytoplasmic localization of retinoblastoma protein in tumor promotion in a rat two-stage thyroid carcinogenesis model.
Retinoblastoma
Kang-ai Injection () Inhibits Gastric Cancer Cells Proliferation through IL-6/STAT3 Pathway.
Retinoblastoma
LncRNA NEAT1 Acts as an miR-148b-3p Sponge to Regulate ROCK1 Inhibition of Retinoblastoma Growth.
Retinoblastoma
Mediation of corticotropin releasing factor type 1 receptor phosphorylation and desensitization by protein kinase C: a possible role in stress adaptation.
Retinoblastoma
MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and cyclin D1.
Retinoblastoma
MicroRNA?330 is downregulated in retinoblastoma and suppresses cell viability and invasion by directly targeting ROCK1.
Retinoblastoma
MicroRNA?448 inhibits the progression of retinoblastoma by directly targeting ROCK1 and regulating PI3K/AKT signalling pathway.
Retinoblastoma
Mir-138-5p acts as a tumor suppressor by targeting pyruvate dehydrogenase kinase 1 in human retinoblastoma.
Retinoblastoma
Molecular characterization of apoptosis induced by CARF silencing in human cancer cells.
Retinoblastoma
Naturally occurring reoviruses for human cancer therapy.
Retinoblastoma
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase.
Retinoblastoma
New Insights into the Molecular Characteristics of Pulmonary Carcinoids and Large Cell Neuroendocrine Carcinomas, and the Impact on Their Clinical Management.
Retinoblastoma
Okadaic acid suppresses TPA-induced differentiation by stimulating G1/S transition in human myeloblastic leukaemia ML-1 cells.
Retinoblastoma
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
Retinoblastoma
Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation.
Retinoblastoma
Prevention of CCAAT/enhancer-binding protein beta DNA binding by hypoxia during adipogenesis.
Retinoblastoma
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Retinoblastoma
Purification and properties of the Xenopus Hat1 acetyltransferase: association with the 14-3-3 proteins in the oocyte nucleus.
Retinoblastoma
Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response.
Retinoblastoma
Rapamycin-induced apoptosis is p53-independent in human prostate carcinoma PC-3 cells.
Retinoblastoma
Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells.
Retinoblastoma
Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235.
Retinoblastoma
Retinoblastoma protein (pRB) was significantly phosphorylated through a Ras-to-MAPK pathway in mutant K-ras stably transfected human adrenocortical cells.
Retinoblastoma
Retinoblastoma suppressor associated protein 46 (RbAp46) attenuates the beta-catenin/TCF signaling through up-regulation of GSK-3beta expression.
Retinoblastoma
Single amino acid substitutions in "low-risk" human papillomavirus (HPV) type 6 E7 protein enhance features characteristic of the "high-risk" HPV E7 oncoproteins.
Retinoblastoma
Structure, regulation, and biological functions of TIGAR and its role in diseases.
Retinoblastoma
Temporal and spatial localization of novel nuclear protein NP95 in mitotic and meiotic cells.
Retinoblastoma
The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site.
Retinoblastoma
The cAMP analog 8-Cl-cAMP inhibits growth and induces differentiation and apoptosis in retinoblastoma cells.
Retinoblastoma
The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein.
Retinoblastoma
The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase.
Retinoblastoma
Transformation by v-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors.
Retinoblastoma
Vitamin D - a new treatment for airway remodelling in asthma?
Retinoblastoma
Vitamin D growth inhibition of breast cancer cells: gene expression patterns assessed by cDNA microarray.
Retinoblastoma
Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1.
Retinoschisis
Characterization of two unusual RS1 gene deletions segregating in Danish retinoschisis families.
Rett Syndrome
CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery.
Rett Syndrome
CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling.
Rett Syndrome
Identification of amphiphysin 1 as an endogenous substrate for CDKL5, a protein kinase associated with X-linked neurodevelopmental disorder.
Rett Syndrome
Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).
Rhabdoid Tumor
Aurora A is a repressed effector target of the chromatin remodeling protein INI1/hSNF5 required for rhabdoid tumor cell survival.
Rhabdoid Tumor
P-Akt expression distinguishes two types of malignant rhabdoid tumors.
Rhabdomyosarcoma
4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.
Rhabdomyosarcoma
Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin.
Rhabdomyosarcoma
Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma.
Rhabdomyosarcoma
Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death.
Rhabdomyosarcoma
Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex.
Rhabdomyosarcoma
Construction and characterization of a conditionally active construct of the insulin-regulated forkhead transcription factor FKHR.
Rhabdomyosarcoma
Definition of regulatory sequence elements in the promoter region and the first intron of the myotonic dystrophy protein kinase gene.
Rhabdomyosarcoma
Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells.
Rhabdomyosarcoma
MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals.
Rhabdomyosarcoma
Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells.
Rhabdomyosarcoma
Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of rapamycin independent of forkhead box O proteins.
Rhabdomyosarcoma
Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling.
Rhabdomyosarcoma
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
Rhabdomyosarcoma
The Kinase Mirk/Dyrk1B Mediates Cell Survival in Pancreatic Ductal Adenocarcinoma.
Rhabdomyosarcoma
The role of protein kinase CK2 in skeletal muscle: Myogenesis, neuromuscular junctions, and rhabdomyosarcoma.
Rhabdomyosarcoma
Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways.
Rhabdomyosarcoma, Alveolar
Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells.
Rhabdomyosarcoma, Alveolar
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Rhabdomyosarcoma, Embryonal
Glycogen synthase kinase 3 inhibitors induce the canonical WNT/?-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.
Rheumatic Diseases
c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases.
Rift Valley Fever
Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis.
Rift Valley Fever
The Rift Valley fever virus nonstructural protein NSs is phosphorylated at serine residues located in casein kinase II consensus motifs in the carboxy-terminus.
Rinderpest
Cellular casein kinase II-mediated phosphorylation of rinderpest virus P protein is a prerequisite for its role in replication/transcription of the genome.
ring-type e3 ubiquitin transferase deficiency
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis.
RNA Virus Infections
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.
RNA Virus Infections
HIPK2 is necessary for type I interferon-mediated antiviral immunity.
Romano-Ward Syndrome
Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region.
Root Resorption
Calcitonin in human odontoclasts regulates root resorption activity via protein kinase A.
Rotavirus Infections
Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis.
Rotavirus Infections
Inhibition of cyclooxygenase activity reduces rotavirus infection at a postbinding step.
Salivary Gland Neoplasms
The PI3K/AKT/mTOR signalling pathway is active in salivary gland cancer and implies different functions and prognoses depending on cell localisation.
Salmonella Infections
Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.
Salmonella Infections
Phosphoproteomic analysis of Salmonella-infected cells identifies key kinase regulators and SopB-dependent host phosphorylation events.
Sarcoidosis
Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening.
Sarcoidosis
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
Sarcoma
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Sarcoma
14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma.
Sarcoma
14-3-3 sigma is a useful immunohistochemical marker for diagnosing ovarian granulosa cell tumors and steroid cell tumors.
Sarcoma
A cAMP-independent serine/threonine kinase activity is associated with the mos sequences of ts110 Moloney murine sarcoma virus-encoded P85gag-mos.
Sarcoma
A murine sarcoma virus-associated protein kinase: interaction with actin and microtubular protein.
Sarcoma
A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells.
Sarcoma
Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome.
Sarcoma
Advances in anti-BRAF therapies for lung cancer.
Sarcoma
Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults.
Sarcoma
Antitumor activity of irradiated riboflavin on human renal carcinoma cell line 786-O.
Sarcoma
Apoptosis induced by chemotherapeutic agents involves c-Jun N-terminal kinase activation in sarcoma cell lines.
Sarcoma
Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer.
Sarcoma
Association between the expression levels of TAZ, AXL and CTGF and clinicopathological parameters in patients with colon cancer.
Sarcoma
Association of Aspirin and Nonsteroidal Anti-Inflammatory Drugs With Colorectal Cancer Risk by Molecular Subtypes.
Sarcoma
Association of BMI and major molecular pathological markers of colorectal cancer in men and women.
Sarcoma
Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis.
Sarcoma
BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates.
Sarcoma
BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives.
Sarcoma
BRAF V600 mutations in Langerhans cell histiocytosis with a simple and unique assay.
Sarcoma
BRAF, a target in melanoma: implications for solid tumor drug development.
Sarcoma
BRAFV600E: Implications for Carcinogenesis and Molecular Therapy.
Sarcoma
C-jun N-terminal kinase activation is required for apoptotic cell death induced by TNF-related apoptosis-inducing ligand plus DNA-damaging agents in sarcoma cell lines.
Sarcoma
Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers.
Sarcoma
Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature.
Sarcoma
Consistency and reproducibility of next-generation sequencing and other multigene mutational assays: A worldwide ring trial study on quantitative cytological molecular reference specimens.
Sarcoma
Consistency and reproducibility of next-generation sequencing in cytopathology: A second worldwide ring trial study on improved cytological molecular reference specimens.
Sarcoma
Construction of a reference material panel for detecting KRAS/NRAS/EGFR/BRAF/MET mutations in plasma ctDNA.
Sarcoma
Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension.
Sarcoma
Decoding the Role of CD271 in Melanoma.
Sarcoma
Design, synthesis and evaluation of wound healing activity for ?-sitosterols derivatives as potent Na+/K+-ATPase inhibitors.
Sarcoma
Differences in symptom occurrence, severity, and distress ratings between patients with gastrointestinal cancers who received chemotherapy alone or chemotherapy with targeted therapy.
Sarcoma
Drug resistance to targeted therapeutic strategies in non-small cell lung cancer.
Sarcoma
Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells.
Sarcoma
EGFR, ALK, RET, KRAS and BRAF alterations in never-smokers with non-small cell lung cancer.
Sarcoma
Electrochemical investigations into Tau protein phosphorylations.
Sarcoma
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment.
Sarcoma
Expression of hepatocyte growth factor and c-Met is characteristic of ?-fetoprotein-producing colorectal adenocarcinoma: A report of three cases.
Sarcoma
Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer.
Sarcoma
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Sarcoma
Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.
Sarcoma
Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.
Sarcoma
Human papillomavirus and gene mutations in head and neck squamous carcinomas.
Sarcoma
Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer.
Sarcoma
Identified a disintegrin and metalloproteinase with thrombospondin motifs 6 serve as a novel gastric cancer prognostic biomarker by bioinformatics analysis.
Sarcoma
Incidence of Lung Adenocarcinoma Biomarker in a Caribbean and African Caribbean Population.
Sarcoma
KRAS and BRAF mutations in serum exosomes from patients with colorectal cancer in a Chinese population.
Sarcoma
KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.
Sarcoma
Light-mediated activation reveals a key role for protein kinase A and sarcoma protein kinase in the development of sperm hyper-activated motility.
Sarcoma
LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma.
Sarcoma
lncRNA SLC16A1-AS1 as a novel prognostic biomarker in non-small cell lung cancer.
Sarcoma
Long-fragment DNA as a potential marker for stool-based detection of colorectal cancer.
Sarcoma
Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma.
Sarcoma
MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas.
Sarcoma
Molecular alterations in non-small cell lung carcinomas of the young.
Sarcoma
Molecular biomarkers and classification models in the evaluation of the prognosis of colorectal cancer.
Sarcoma
Molecular Mechanism of Hydroxyurea Enhances K562 Cell Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand.
Sarcoma
Multiple primary malignant neoplasms: A case report and literature review.
Sarcoma
Mutated mitogen-activated protein kinase: a tumor rejection antigen of mouse sarcoma.
Sarcoma
Mutational Profile of Papillary Thyroid Carcinoma in an Endemic Goiter Region of North India.
Sarcoma
New BRAF (v raf murine sarcoma viral oncogene homologue B1) mutation in rheumatoid arthritis.
Sarcoma
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.
Sarcoma
Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ?50%: real-world data.
Sarcoma
Polo-like kinase 2 promotes chemoresistance and predicts limited survival benefit from adjuvant chemotherapy in colorectal cancer.
Sarcoma
Profiling Oncogenic Germline Mutations in Unselected Chinese Lung Cancer Patients.
Sarcoma
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Sarcoma
Prognostic significance of activated AKT expression in soft-tissue sarcoma.
Sarcoma
Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-?B and matrix metalloproteinase-2/-9 signaling pathways.
Sarcoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Sarcoma
Raf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sarcomas.
Sarcoma
RASSF1A promotes apoptosis and suppresses the proliferation of ovarian cancer cells.
Sarcoma
Recent developments in salvage chemotherapy for patients with metastatic soft tissue sarcoma.
Sarcoma
Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Sarcoma
Serine kinase activity associated with Maloney murine sarcoma virus-124-encoded p37mos.
Sarcoma
Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.
Sarcoma
Silencing of advanced glycosylation and glycosylation and product-specific receptor (RAGE) inhibits the metastasis and growth of non-small cell lung cancer.
Sarcoma
Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways.
Sarcoma
Standards and novel therapeutic options in the treatment of patients with soft tissue sarcoma.
Sarcoma
Survival analysis in Caucasian pulmonary adenocarcinoma patients based on differential targets between Caucasian and Asian population.
Sarcoma
Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines.
Sarcoma
Targeting Autophagy for Overcoming Resistance to Anti-EGFR Treatments.
Sarcoma
Targeting BRAF and RAS in Colorectal Cancer.
Sarcoma
TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases.
Sarcoma
Triiodothyronine stimulates steroid and VEGF production in murine Leydig cells via cAMP-PKA pathway.
Sarcoma
Use of 5'-?-Ferrocenyl Adenosine Triphosphate (Fc-ATP) Bioconjugates Having Poly(ethylene glycol) Spacers in Kinase-Catalyzed Phosphorylations.
Sarcoma
Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met.
Sarcoma
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
Sarcoma
Yield and Clinical Utility of Next-Generation Sequencing in Selected Patients With Lung Adenocarcinoma.
Sarcoma
[Genetic Profile of Young Chinese Patients with Lung Adenocarcinoma].
Sarcoma, Avian
A similar ribosomal protein S6 kinase activity is found in insulin-treated 3T3-L1 cells and chick embryo fibroblasts transformed by Rous sarcoma virus.
Sarcoma, Avian
Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus.
Sarcoma, Avian
Mechanisms of insulin-like growth factor I augmentation of follicle-stimulating hormone-induced porcine steroidogenic acute regulatory protein gene promoter activity in granulosa cells.
Sarcoma, Avian
Phosphorylation of a high molecular weight DNA polymerase alpha.
Sarcoma, Avian
Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus.
Sarcoma, Avian
Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis.
Sarcoma, Avian
Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma virus transforming protein, serum, or phorbol ester.
Sarcoma, Endometrial Stromal
14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma.
Sarcoma, Endometrial Stromal
14-3-3 sigma is a useful immunohistochemical marker for diagnosing ovarian granulosa cell tumors and steroid cell tumors.
Sarcoma, Ewing
Arsenic trioxide inhibits Ewing's sarcoma cell invasiveness by targeting p38(MAPK) and c-Jun N-terminal kinase.
Sarcoma, Ewing
Atypical Protein Kinase C? Is Required for Wnt3a-dependent Neurite Outgrowth and Binds to Phosphorylated Dishevelled 2.
Sarcoma, Ewing
EWS-Fli1 up-regulates expression of the Aurora A and Aurora B kinases.
Sarcoma, Ewing
Identifying the molecular phenotype of renal progenitor cells.
Sarcoma, Ewing
Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.
Sarcoma, Ewing
mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells.
Sarcoma, Ewing
NF-kappaB activation prevents apoptotic oxidative stress via an increase of both thioredoxin and MnSOD levels in TNFalpha-treated Ewing sarcoma cells.
Sarcoma, Ewing
Oncogenic serine-threonine kinase receptor-associated protein modulates the function of Ewing sarcoma protein through a novel mechanism.
Sarcoma, Ewing
Targeting ROCK2 rather than ROCK1 inhibits Ewing sarcoma malignancy.
Sarcoma, Ewing
[Expression of metanephric differentiation markers in human mesenchymal stem cells].
Sarcoma, Kaposi
HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.
Sarcoma, Kaposi
Interaction With 14-3-3 Correlates With Inactivation of the RIG-I Signalosome by Herpesvirus Ubiquitin Deconjugases.
Sarcoma, Kaposi
Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and autophagy.
Sarcoma, Kaposi
Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation.
Sarcoma, Kaposi
Monitoring antitumor efficacy of rapamycin in Kaposi sarcoma.
Sarcoma, Kaposi
ORF36 protein kinase of Kaposi's sarcoma herpesvirus activates the c-Jun N-terminal kinase signaling pathway.
Sarcoma, Synovial
Phosphatidylinositol-3'-kinase/AKT signalling is essential in synovial sarcoma.
Schistosomiasis
Detection of IgG in sera of patients with schistosomiasis japonica by developing magnetic affinity enzyme-linked immunoassay based on recombinant 14-3-3 protein.
Schistosomiasis
The 14-3-3 protein as a vaccine candidate against schistosomiasis.
Schistosomiasis
[Characterization and preliminary application of six monoclonal antibodies against recombinant signal protein 14-3-3 of Schistosoma japonicum].
Schistosomiasis japonica
Application of signaling protein 14-3-3 and 26 kDa glutathione-S-transferase to serological diagnosis of Schistosomiasis japonica.
Schistosomiasis japonica
Detection of IgG in sera of patients with schistosomiasis japonica by developing magnetic affinity enzyme-linked immunoassay based on recombinant 14-3-3 protein.
Schistosomiasis mansoni
Protein kinase A signalling in Schistosoma mansoni cercariae and schistosomules.
Scleroderma, Systemic
A cell model system to study regulation of phosphotidylinositol 3-kinase and protein kinase B activity by cytokines/growth factors produced by type I collagen stimulated immune cells from patients with systemic sclerosis.
Scleroderma, Systemic
Alteration in protein kinase B (AKT) activity in platelets from patients with systemic sclerosis.
Scleroderma, Systemic
Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and its Pharmacokinetic Application.
Scleroderma, Systemic
Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts.
Scleroderma, Systemic
Inhibition of glycogen synthase kinase 3{beta} induces dermal fibrosis by activation of the canonical Wnt pathway.
Scoliosis
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Scrapie
Binding of 14-3-3 proteins to a single stranded oligodeoxynucleotide aptamer.
Scrapie
Different expression patterns of CK2 subunits in the brains of experimental animals and patients with transmissible spongiform encephalopathies.
Scrapie
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain.
Scrapie
Infection of Prions and Treatment of PrP106-126 Alter the Endogenous Status of Protein 14-3-3 and Trigger the Mitochondrial Apoptosis Possibly via Activating Bax Pathway.
Scrapie
The 14-3-3 cerebrospinal fluid immunoassay lacks utility in the diagnosis of clinical scrapie.
Seizures
14-3-3? and ? regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain.
Seizures
A mechanism for the inactivation of Ca2+/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo.
Seizures
Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death.
Seizures
Antiepileptic Effect of Uncaria rhynchophylla and Rhynchophylline Involved in the Initiation of c-Jun N-Terminal Kinase Phosphorylation of MAPK Signal Pathways in Acute Seizures of Kainic Acid-Treated Rats.
Seizures
Bi-directional genetic modulation of GSK-3? exacerbates hippocampal neuropathology in experimental status epilepticus.
Seizures
Brief seizure activity alters Ca2+/calmodulin dependent protein kinase II dephosphorylation and subcellular distribution in rat brain for several hours.
Seizures
Ca2+/calmodulin-dependent protein kinase II is reversibly autophosphorylated, inactivated and made sedimentable by acute neuronal excitation in rats in vivo.
Seizures
Calcium/calmodulin kinase II activity of hippocampus in kainate-induced epilepsy.
Seizures
Decreased expression of the alpha subunit of Ca2+/ calmodulin-dependent protein kinase type II mRNA in the adult rat CNS following recurrent limbic seizures.
Seizures
Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.
Seizures
Detection of 14-3-3zeta in cerebrospinal fluid following experimentally evoked seizures.
Seizures
DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures.
Seizures
Downregulated GPR30 expression in the epileptogenic foci of female patients with focal cortical dysplasia type IIb and tuberous sclerosis complex is correlated with 18 F-FDG PET-CT values.
Seizures
Effects of pentoxifylline and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice.
Seizures
Electric Stimulation of Ear Reduces the Effect of Toll-Like Receptor 4 Signaling Pathway on Kainic Acid-Induced Epileptic Seizures in Rats.
Seizures
Food deprivation attenuates seizures through CaMKII and EAG K+ channels.
Seizures
Glycogen Synthase Kinase-3 Inhibitors Reverse Deficits in Long-term Potentiation and Cognition in Fragile X Mice.
Seizures
Hippocampal neuronal death induced by kainic acid and restraint stress is suppressed by exercise.
Seizures
Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy.
Seizures
Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function.
Seizures
Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
Seizures
Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1.
Seizures
Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain.
Seizures
Interaction of 14-3-3 with Bid during seizure-induced neuronal death.
Seizures
Involvement of cAMP- and Ca(2+)/calmodulin-dependent neuronal protein phosphorylation in mechanisms underlying genetic predisposition to audiogenic seizures in rats.
Seizures
Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy.
Seizures
Kainic acid-induced seizures activate GSK-3beta in the hippocampus of D2R-/- mice.
Seizures
Ketogenic diet protects the hippocampus from kainic acid toxicity by inhibiting the dissociation of bad from 14-3-3.
Seizures
Lethal neonatal rigidity and multifocal seizure syndrome with a new mutation in BRAT1.
Seizures
Long-lasting decrease in neuronal Ca2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent seizures.
Seizures
N-methyl-D-aspartate receptor dependent transcriptional regulation of two calcium/calmodulin-dependent protein kinase type II isoforms in rodent cerebral cortex.
Seizures
Neonatal hypocalcemic seizures in siblings exposed to topiramate in utero.
Seizures
Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure.
Seizures
Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence.
Seizures
Overexpression of 14-3-3? Increases Brain Levels of C/EBP Homologous Protein CHOP.
Seizures
PLPP/CIN-mediated NF2-serine 10 dephosphorylation regulates F-actin stability and Mdm2 degradation in an activity-dependent manner.
Seizures
Prolonged changes in Ca2+/calmodulin-dependent protein kinase II after a brief pentylenetetrazol seizure; potential role in kindling.
Seizures
Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus.
Seizures
Protein kinase Cdelta is associated with 14-3-3 phosphorylation in seizure-induced neuronal death.
Seizures
Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain.
Seizures
Repetitive electroconvulsive seizures induce activity of c-Jun N-terminal kinase and compartment-specific desensitization of c-Jun phosphorylation in the rat brain.
Seizures
Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
Seizures
Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat.
Seizures
The Ca2+/calmodulin signaling system in the neural response to excitability. Involvement of neuronal and glial cells.
Seizures
The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.
Seizures
The Putative Role of mTOR Inhibitors in Non-tuberous Sclerosis Complex-Related Epilepsy.
Seizures
Thymoquinone and Vitamin C Attenuates Pentylenetetrazole-Induced Seizures Via Activation of GABAB1 Receptor in Adult Rats Cortex and Hippocampus.
Seizures
Unravelling the Role of Glycogen Synthase Kinase-3 in Alzheimer's Disease-Related Epileptic Seizures.
Seizures
[Dephosphorelation of Bad and upregulation of Bcl-2 in hippocampus of rats following limbic seizure induced by kainic acid injection into amygdaloid nucleus]
Seizures
[Effect of seizure activity on subunit composition of Ca2+/calmodulin-dependent protein kinase II in hippocampus of Krushinskii-Molodkina rats].
Seizures, Febrile
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Seizures, Febrile
Febrile seizures: characterization of double-stranded RNA-induced gene expression.
Seizures, Febrile
Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population.
Seizures, Febrile
[Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions]
Seminoma
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Seminoma
14-3-3 beta in the healthy and diseased male reproductive system.
Seminoma
A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells.
Seminoma
Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A.
Seminoma
GPER and Testicular Germ Cell Cancer.
Seminoma
Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis.
Seminoma
TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway.
Sepsis
Alternations of 14-3-3 ? and ? protein levels in brain during experimental sepsis.
Sepsis
Artesunate ameliorates sepsis-induced acute lung injury by activating the mTOR/AKT/PI3K axis.
Sepsis
Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1? in liver.
Sepsis
Calpain activity and muscle wasting in sepsis.
Sepsis
CaMKII activity is reduced in skeletal muscle during sepsis.
Sepsis
CaMKII-dependent ryanodine receptor phosphorylation mediates sepsis-induced cardiomyocyte apoptosis.
Sepsis
Characterization and Outcome of Two Pediatric Intensive Care Units with Different Resources.
Sepsis
Differential activation of protein kinase A in various regions of myocardium during sepsis.
Sepsis
Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies.
Sepsis
Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis.
Sepsis
Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigs.
Sepsis
Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation.
Sepsis
Glycogen synthase kinase-3beta suppresses tumor necrosis factor-alpha expression in cardiomyocytes during lipopolysaccharide stimulation.
Sepsis
GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat.
Sepsis
GSK-3beta inhibitors reduce protein degradation in muscles from septic rats and in dexamethasone-treated myotubes.
Sepsis
HIPK2 phosphorylates HDAC3 for NF-?B acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.
Sepsis
HIPK2 sustains inflammatory cytokine production by promoting endoplasmic reticulum stress in macrophages.
Sepsis
Inhibiting glycogen synthase kinase 3beta in sepsis.
Sepsis
Inhibition of glycogen synthase kinase (GSK)-3-? improves liver microcirculation and hepatocellular function after hemorrhagic shock.
Sepsis
Liver protein kinase A activity is decreased during the late hypoglycemic phase of sepsis.
Sepsis
lncRNA MALAT1 Accelerates Skeletal Muscle Cell Apoptosis and Inflammatory Response in Sepsis by Decreasing BRCA1 Expression by Recruiting EZH2.
Sepsis
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.
Sepsis
MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis.
Sepsis
Mechanisms of Ataxia Telangiectasia Mutated (ATM) Control in the DNA Damage Response to Oxidative Stress, Epigenetic Regulation, and Persistent Innate Immune Suppression Following Sepsis.
Sepsis
Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.
Sepsis
Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy.
Sepsis
Phosphorylation of eukaryotic initiation factor eIF2Bepsilon in skeletal muscle during sepsis.
Sepsis
Protective Role of Peroxisome Proliferator-Activated Receptor-{beta}/{delta} in Septic Shock.
Sepsis
Protein kinase a activity is increased in rat heart during late hypodynamic phase of sepsis.
Sepsis
Regulatory effect of lncRNA NKILA on autophagy induced by sepsis kidney injury.
Sepsis
Role of connexin 43 in vascular hyperpermeability and relationship to Rock1-MLC20 pathway in septic rats.
Sepsis
[Kinetic studies of protein kinase A in rat liver during early sepsis]
Sepsis
[Kinetic studies of protein kinase A in rat liver during late sepsis]
Sepsis
[Role of Rho/ROCK signaling pathway in the protective effects of hydrogen against acute lung injury in septic mice].
Sepsis
[Sepsis induces JNK and CHOP pathways apoptosis of lymphoid organs and stimulates inflammatory cytokines changes in the mice].
Sertoli Cell Tumor
Germline mutation in the STK11 gene in a girl with an ovarian Sertoli cell tumour.
Sertoli Cell-Only Syndrome
A PLK4 mutation causing azoospermia in a man with Sertoli cell-only syndrome.
Severe Acute Respiratory Syndrome
Coronavirus interactions with the cellular autophagy machinery.
Severe Acute Respiratory Syndrome
Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication.
Severe Acute Respiratory Syndrome
Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
Severe Acute Respiratory Syndrome
mTOR inhibition and p53 activation, microRNAs: The possible therapy against pandemic COVID-19.
Severe Combined Immunodeficiency
A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p.
Severe Combined Immunodeficiency
Adaptive response and the influence of ageing: effects of low-dose irradiation on cell growth of cultured glial cells.
Severe Combined Immunodeficiency
Characterization of the promoter region, first ten exons and nine intron-exon boundaries of the DNA-dependent protein kinase catalytic subunit gene, DNA-PKcs (XRCC7).
Severe Combined Immunodeficiency
DNA-dependent protein kinase does not play a role in adaptive survival responses to ionizing radiation.
Severe Combined Immunodeficiency
DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties.
Severe Combined Immunodeficiency
DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination.
Severe Combined Immunodeficiency
Existence of a threshold-like dose for gamma-ray induction of thymic lymphomas and no susceptibility to radiation-induced solid tumors in SCID mice.
Severe Combined Immunodeficiency
Expression of DNA-dependent protein kinase holoenzyme upon induction of lymphocyte differentiation and V(D)J recombination.
Severe Combined Immunodeficiency
Generation and Characterization of Severe Combined Immunodeficiency Rats.
Severe Combined Immunodeficiency
Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis.
Severe Combined Immunodeficiency
Glycogen synthase kinase-3beta inhibition preserves hematopoietic stem cell activity and inhibits leukemic cell growth.
Severe Combined Immunodeficiency
Interaction between DNA-dependent protein kinase and a novel protein, KIP.
Severe Combined Immunodeficiency
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.
Severe Combined Immunodeficiency
Minisatellite instability in severe combined immunodeficiency mouse cells.
Severe Combined Immunodeficiency
Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency.
Severe Combined Immunodeficiency
Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice.
Severe Combined Immunodeficiency
Pathways of removal of free DNA vector ends in normal and DNA-PKcs-deficient SCID mouse hepatocytes transduced with rAAV vectors.
Severe Combined Immunodeficiency
Radiation-induced apoptosis in scid mice spleen after low dose irradiation.
Severe Combined Immunodeficiency
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.
Sex Cord-Gonadal Stromal Tumors
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Morphologic and Molecular Study of 26 Cases Confirms Recurrent NCOA1-3 Rearrangement.
Shock, Septic
Glycogen synthase kinase 3beta as a target for the therapy of shock and inflammation.
Shock, Septic
GSK3beta Inhibitor Peptide Protects Mice from LPS-induced Endotoxin Shock.
Shock, Septic
Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.
Shock, Septic
Protein kinase C delta (PKC?)-extracellular-signal regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia.
Sialadenitis
Epigallocatechin gallate stimulates the neuroreactive salivary secretomotor system in autoimmune sialadenitis of MRL-Fas(lpr) mice via activation of cAMP-dependent protein kinase A and inactivation of nuclear factor ?B.
Sick Sinus Syndrome
CaMKII oxidative activation and the pathogenesis of cardiac disease.
Sick Sinus Syndrome
Insulin sensitization causes accelerated sinus nodal dysfunction through autophagic dysregulation in hypertensive mice.
Sick Sinus Syndrome
Oxidized CaMKII causes cardiac sinus node dysfunction in mice.
Sick Sinus Syndrome
Protective effects of kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization.
Sick Sinus Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Situs Inversus
Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos.
Skin Diseases
A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.
Skin Diseases
An Update on Autoinflammatory Diseases: Inflammasomopathies.
Skin Diseases
Inhibiting Glycogen Synthase Kinase-3 Decreases 12-O-Tetradecanoylphorbol-13-Acetate-Induced Interferon-?-Mediated Skin Inflammation.
Skin Diseases
Regulation of the catalytic activity of herpes simplex virus 1 protein kinase Us3 by autophosphorylation and its role in pathogenesis.
Skin Neoplasms
3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase in vitro and in vivo.
Skin Neoplasms
Decoding the Role of CD271 in Melanoma.
Skin Neoplasms
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Skin Neoplasms
Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Skin Neoplasms
MicroRNA-21 activation of Akt via PTEN is involved in the epithelial-mesenchymal transition and malignant transformation of human keratinocytes induced by arsenite.
Skin Neoplasms
Monitoring antitumor efficacy of rapamycin in Kaposi sarcoma.
Skin Neoplasms
NAMPT Over-Expression Recapitulates the BRAF Inhibitor Resistant Phenotype Plasticity in Melanoma.
Skin Neoplasms
The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer.
Sleep Apnea, Obstructive
Reduced Peripheral Blood Mononuclear Cell ROCK1 and ROCK2 Levels in Obstructive Sleep Apnea Syndrome.
Sleep Deprivation
Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders.
Sleep Deprivation
Fxr1 regulates sleep and synaptic homeostasis.
Sleep Deprivation
Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: Role of oxidative stress, BDNF and CaMKII.
Sleep Deprivation
Phosphorylation of CaMKII in the rat dorsal raphe nucleus plays an important role in sleep-wake regulation.
Sleep Deprivation
Rolipram rescues memory consolidation deficits caused by sleep deprivation: Implication of the cAMP/PKA and cAMP/Epac pathways.
Sleep Deprivation
Sleep deprivation impairs cAMP signalling in the hippocampus.
Sleep Deprivation
Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning.
Sleep Deprivation
Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease.
Sleep Deprivation
Suppression of hippocampal plasticity-related gene expression by sleep deprivation in rats.
Sleep Disorders, Circadian Rhythm
A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders.
Sleep Disorders, Circadian Rhythm
Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders.
Sleep Wake Disorders
A comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism.
Sleep Wake Disorders
A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders.
Sleep Wake Disorders
Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders.
Sleep Wake Disorders
Computational Analysis of N-acetyl transferase in Tribolium castaneum.
Sleep Wake Disorders
Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease.
Sleep Wake Disorders
Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters.
Sleep Wake Disorders
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers.
Small Cell Lung Carcinoma
Activated Raf-1 causes growth arrest in human small cell lung cancer cells.
Small Cell Lung Carcinoma
Assays for raf-1 kinase phosphorylation and activity in human small cell lung cancer cells.
Small Cell Lung Carcinoma
Doxorubicin induces expression of multidrug resistance-associated protein 1 in human small cell lung cancer cell lines by the c-jun N-terminal kinase pathway.
Small Cell Lung Carcinoma
Expression and prognostic significance of kit, protein kinase B, and mitogen-activated protein kinase in patients with small cell lung cancer.
Small Cell Lung Carcinoma
Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
Small Cell Lung Carcinoma
Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers.
Small Cell Lung Carcinoma
Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C.
Small Cell Lung Carcinoma
Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells.
Small Cell Lung Carcinoma
Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer.
Small Cell Lung Carcinoma
The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway.
Small Cell Lung Carcinoma
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.
Small Cell Lung Carcinoma
[Analyzed the molecular interaction network of tumor suppressor gene 14-3-3 sigma in lung cancer cell based on stable isotope labeling by amino acids in cell culture technology].
Small Cell Lung Carcinoma
[Effect of basic fibroblast growth factor antibody combined with irinotecan on proliferation and apoptosis of small cell lung cancer H223 cells in vitro].
Smith-Magenis Syndrome
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Sotos Syndrome
A child with an STK11 mutation and Sotos syndrome-like features: can STK11 mutations produce a Sotos syndrome phenocopy?
Spasms, Infantile
CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling.
Spasms, Infantile
Disruption of the serine/threonine kinase 9 gene causes severe X-linked infantile spasms and mental retardation.
Spasms, Infantile
Genetics of the epilepsies.
Spasms, Infantile
Identification of amphiphysin 1 as an endogenous substrate for CDKL5, a protein kinase associated with X-linked neurodevelopmental disorder.
Spastic Paraplegia, Hereditary
Oxidative DNA Damage and Activation of c-Jun N-Terminal Kinase Pathway in Fibroblasts from Patients with Hereditary Spastic Paraplegia.
Spermatic Cord Torsion
The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in testicular torsion and autoimmune orchitis.
Spina Bifida Cystica
Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling.
Spinal Cord Compression
Apoptosis in human compressive myelopathy due to metastatic neoplasia.
Spinal Cord Diseases
Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis.
Spinal Cord Injuries
(284) Persistent electrical activity in primary nociceptors after spinal cord injury is maintained by scaffolded adenylyl cyclase and protein kinase A and is associated with altered adenylyl cyclase regulation.
Spinal Cord Injuries
Activation of Neurogenesis in Multipotent Stem Cells Cultured In Vitro and in the Spinal Cord Tissue After Severe Injury by Inhibition of Glycogen Synthase Kinase-3.
Spinal Cord Injuries
AR-A014418 as a glycogen synthase kinase-3 inhibitor: Anti-apoptotic and therapeutic potential in experimental spinal cord injury.
Spinal Cord Injuries
ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats.
Spinal Cord Injuries
C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice.
Spinal Cord Injuries
Combined application of Rho-ROCKII and GSK-3? inhibitors exerts an improved protective effect on axonal regeneration in rats with spinal cord injury.
Spinal Cord Injuries
Effect of electroacupuncture on the mRNA and protein expression of Rho-A and Rho-associated kinase II in spinal cord injury rats.
Spinal Cord Injuries
Effects of hyperbaric oxygen on glucose-regulated protein 78 and c-Jun N-terminal kinase expression after spinal cord injury in rats.
Spinal Cord Injuries
Electroacupuncture improves neurogenic bladder dysfunction through activation of NGF/TrkA signaling in a rat model.
Spinal Cord Injuries
Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma.
Spinal Cord Injuries
GSK-3 Inhibitor Promotes Neuronal Cell Regeneration and Functional Recovery in a Rat Model of Spinal Cord Injury.
Spinal Cord Injuries
GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.
Spinal Cord Injuries
Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS.
Spinal Cord Injuries
Ischemic preconditioning suppresses apoptosis of rabbit spinal neurocytes by inhibiting ASK1-14-3-3 dissociation.
Spinal Cord Injuries
Lentiviral Vector Mediates Exogenous Gene Expression in Adult Rat DRG Following Peripheral Nerve Remote Delivery.
Spinal Cord Injuries
miR-152 promotes spinal cord injury recovery via c-jun amino terminal kinase pathway.
Spinal Cord Injuries
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury.
Spinal Cord Injuries
Overexpression of HIPK2 attenuates spinal cord injury in rats by modulating apoptosis, oxidative stress, and inflammation.
Spinal Cord Injuries
Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.
Spinal Cord Injuries
Reactive oxygen species contribute to neuropathic pain and locomotor dysfunction via activation of CamKII in remote segments following spinal cord contusion injury in rats.
Spinal Cord Injuries
Resveratrol ameliorates autophagic flux to promote functional recovery in rats after spinal cord injury.
Spinal Cord Injuries
Serine-threonine protein kinase activation may be an effective target for reducing neuronal apoptosis after spinal cord injury.
Spinal Cord Injuries
Temporal-spatial expressions of p27(kip1) and its phosphorylation on Serine-10 after acute spinal cord injury in adult rat: Implications for post-traumatic glial proliferation.
Spinal Cord Injuries
The change tendency of PI3K/Akt pathway after spinal cord injury.
Spinal Cord Ischemia
Inactivation and subcellular redistribution of Ca2+/calmodulin-dependent protein kinase II following spinal cord ischemia.
Spinal Cord Ischemia
Neuroprotective effects of activated protein C through induction of insulin-like growth factor-1 (IGF-1), IGF-1 receptor, and its downstream signal phosphorylated serine-threonine kinase after spinal cord ischemia in rabbits.
Spinal Cord Ischemia
Reduced protein kinase C activity in ischemic spinal cord.
Spinal Dysraphism
Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling.
Spinal Dysraphism
Genes encoding catalytic subunits of protein kinase A and risk of spina bifida.
Spinal Dysraphism
MARK2/Par1b Insufficiency Attenuates DVL Gene Transcription via Histone Deacetylation in Lumbosacral Spina Bifida.
Spinocerebellar Ataxias
14-3-3 Proteins and Spinocerebellar Ataxia Type 1: from Molecular Interaction to Human Neuropathology.
Spinocerebellar Ataxias
Anticipation of onset age in familial Parkinson's disease without SCA gene mutations.
Spinocerebellar Ataxias
CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.
Spinocerebellar Ataxias
Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation.
Spinocerebellar Ataxias
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Spinocerebellar Ataxias
Identification and characterization of PKC?, a kinase associated with SCA14, as an amyloidogenic protein.
Spinocerebellar Ataxias
Identification of a novel phosphorylation site in ataxin-1.
Spinocerebellar Ataxias
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Spinocerebellar Ataxias
Intranuclear immunolocalization of 14-3-3 protein isoforms in brains with spinocerebellar ataxia type 1.
Spinocerebellar Ataxias
Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
Spinocerebellar Ataxias
Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.
Spinocerebellar Ataxias
Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration.
Spinocerebellar Ataxias
Serine/threonine kinase 17b (STK17B) signaling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.
Spinocerebellar Ataxias
Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.
Spinocerebellar Ataxias
The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions.
Spinocerebellar Ataxias
Yeast 14-3-3 proteins.
Spondylitis, Ankylosing
MicroRNA let-7i-3p affects osteoblast differentiation in ankylosing spondylitis via targeting PDK1.
Squamous Cell Carcinoma of Head and Neck
A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment.
Squamous Cell Carcinoma of Head and Neck
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival.
Squamous Cell Carcinoma of Head and Neck
Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Antisense raf oligodeoxyribonucleotide is a radiosensitizer in vivo.
Squamous Cell Carcinoma of Head and Neck
Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Ataxia-telangiectasia mutated interactor regulates head and neck cancer metastasis via KRas expression.
Squamous Cell Carcinoma of Head and Neck
c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines.
Squamous Cell Carcinoma of Head and Neck
Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation.
Squamous Cell Carcinoma of Head and Neck
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Squamous Cell Carcinoma of Head and Neck
CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Clinical significance of raf-1 kinase inhibitor protein in oral squamous cell carcinoma and its role in cell metastasis.
Squamous Cell Carcinoma of Head and Neck
Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck.
Squamous Cell Carcinoma of Head and Neck
CX-4945 and siRNA-Mediated Knockdown of CK2 Improves Cisplatin Response in HPV(+) and HPV(-) HNSCC Cell Lines.
Squamous Cell Carcinoma of Head and Neck
Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis.
Squamous Cell Carcinoma of Head and Neck
Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
DNA-dependent protein kinase catalytic subunit functions in metastasis and influences survival in advanced-stage laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery.
Squamous Cell Carcinoma of Head and Neck
Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival.
Squamous Cell Carcinoma of Head and Neck
Dysregulation of splicing proteins in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Effect of ATR Inhibition in RT Response of HPV-Negative and HPV-Positive Head and Neck Cancers.
Squamous Cell Carcinoma of Head and Neck
Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.
Squamous Cell Carcinoma of Head and Neck
Evaluation of the p-AKT, p-JNK and FoxO3a function in oral epithelial dysplasia.
Squamous Cell Carcinoma of Head and Neck
Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression.
Squamous Cell Carcinoma of Head and Neck
Expression and prognostic significance of the P53-related DNA damage repair proteins checkpoint kinase 1 (CHK1) and growth arrest and DNA-damage-inducible 45 alpha (GADD45A) in human oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Expression of DNA-dependent protein kinase catalytic subunit in laryngeal squamous cell carcinoma and its importance.
Squamous Cell Carcinoma of Head and Neck
Expression of protein tyrosine kinases in head and neck squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Inactivation of homeodomain-interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53-dependent E-cadherin expression.
Squamous Cell Carcinoma of Head and Neck
Increased PD-L1 expression in radioresistant HNSCC cell lines after irradiation affects cell proliferation due to inactivation of GSK-3beta.
Squamous Cell Carcinoma of Head and Neck
Inhibitory Effect of 1,8-Cineol on ?-Catenin Regulation, WNT11 Expression, and Cellular Progression in HNSCC.
Squamous Cell Carcinoma of Head and Neck
Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Involvement of the Wnt-?-catenin pathway in invasion and migration of oral squamous carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Knockdown of HPIP Inhibits the Proliferation and Invasion of Head-and-Neck Squamous Cell Carcinoma Cells by Regulating PI3K/Akt Signaling Pathway.
Squamous Cell Carcinoma of Head and Neck
LASP1 promotes proliferation, metastasis, invasion in head and neck squamous cell carcinoma and through direct interaction with HSPA1A.
Squamous Cell Carcinoma of Head and Neck
Long noncoding RNA MORT overexpression inhibits cancer cell proliferation in oral squamous cell carcinoma by downregulating ROCK1.
Squamous Cell Carcinoma of Head and Neck
Loss of 14-3-3 sigma protein expression and presence of human papillomavirus type 16 E6 in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.
Squamous Cell Carcinoma of Head and Neck
MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Metallothionein and p-Akt proteins in oral dysplasia and in oral squamous cell carcinoma: an immunohistochemical study.
Squamous Cell Carcinoma of Head and Neck
Methylation and intratumoural heterogeneity of 14-3-3 sigma in oral cancer.
Squamous Cell Carcinoma of Head and Neck
MicroRNA-140-5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21-activated kinase 4.
Squamous Cell Carcinoma of Head and Neck
MicroRNA?195 inhibits cell proliferation, migration and invasion in laryngeal squamous cell carcinoma by targeting ROCK1.
Squamous Cell Carcinoma of Head and Neck
Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
p-Akt and its relationship with clinicopathological features and survival in oral squamous cell carcinoma: an immunohistochemical study.
Squamous Cell Carcinoma of Head and Neck
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Patterns of gene promoter methylation in squamous cell cancer of the head and neck.
Squamous Cell Carcinoma of Head and Neck
Phosphorylated p63 induces transcription of regulatory particle non ATP-ase subunit 13 and nitric oxide synthase-2 protein degradation.
Squamous Cell Carcinoma of Head and Neck
Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Proteomic profiling of differential display analysis for human oral squamous cell carcinoma: 14-3-3 ? Protein is upregulated in human oral squamous cell carcinoma and dependent on the differentiation level.
Squamous Cell Carcinoma of Head and Neck
Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Squamous Cell Carcinoma of Head and Neck
Significance of mammalian target of rapamycin in patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil.
Squamous Cell Carcinoma of Head and Neck
Silencing of long non-coding RNA CCAT2 depressed malignancy of oral squamous cell carcinoma via Wnt/?-catenin pathway.
Squamous Cell Carcinoma of Head and Neck
STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis.
Squamous Cell Carcinoma of Head and Neck
STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Squamous Cell Carcinoma of Head and Neck
STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-?1.
Squamous Cell Carcinoma of Head and Neck
Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons.
Squamous Cell Carcinoma of Head and Neck
Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death.
Squamous Cell Carcinoma of Head and Neck
Teasing out the best molecular marker in the AKT/mTOR pathway in head and neck squamous cell cancer patients.
Squamous Cell Carcinoma of Head and Neck
The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.
Squamous Cell Carcinoma of Head and Neck
The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro.
Squamous Cell Carcinoma of Head and Neck
The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
The Potential Prognostic Value of Connexin 43 Expression in Head and Neck Squamous Cell Carcinomas.
Squamous Cell Carcinoma of Head and Neck
The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.
Squamous Cell Carcinoma of Head and Neck
Therapeutic targeting of protein kinase CK2 gene expression in feline oral squamous cell carcinoma - a naturally occurring large animal model of head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
[Expression and clinical significance of serine-threonine kinase/mammalian target of rapamycin/p70 S6K signal path- way in oral squamous cell carcinoma].
Squamous Cell Carcinoma of Head and Neck
[Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation].
Squamous Cell Carcinoma of Head and Neck
[Expressions of SMG-1, ATM and P53 in laryngeal squamous cell carcinoma and their clinical significance].
Squamous Cell Carcinoma of Head and Neck
[Protein kinase D1 regulates the growth and metabolism of oral squamous carcinoma cells in tumor microenvironment].
Squamous Cell Carcinoma of Head and Neck
[The expression and activity of protein kinase A I in oral squamous cell carcinoma.]
Squamous Cell Carcinoma of Head and Neck
[The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma]
Squamous Cell Carcinoma of Head and Neck
[The study of serine/threonine kinase signaling pathway-mediated inhibition of proliferation and invasion of oral squamous cell carcinoma transfected with p53 gene].
ST Elevation Myocardial Infarction
Increased Rho kinase activity predicts worse cardiovascular outcome in ST-segment elevation myocardial infarction patients.
Staphylococcal Infections
Identification of the differential expression of genes and upstream microRNAs in small cell lung cancer compared with normal lung based on bioinformatics analysis.
Starvation
A defect in nir1, a nirA-like transcription factor, confers morphological abnormalities and loss of pathogenicity in Colletotrichum acutatum.
Starvation
A New alpha5beta1 integrin-dependent survival pathway through GSK3beta activation in leukemic cells.
Starvation
A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival.
Starvation
A role for AMPK in increased insulin action after serum starvation.
Starvation
Adaptation to sustained nitrogen starvation by Escherichia coli requires the eukaryote-like serine/threonine kinase YeaG.
Starvation
AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells.
Starvation
Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death.
Starvation
Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway.
Starvation
Autophagy under glucose starvation enhances protein translation initiation in response to re-addition of glucose in C2C12 myotubes.
Starvation
Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons.
Starvation
Combined Short-Term Glucose Starvation and Chemotherapy in 3D Colorectal Cancer Cell Culture Decreases 14-3-3 Family Protein Expression and Phenotypic Response to Therapy.
Starvation
Complex Formation, Phosphorylation, and Localization of Protein Kinase A of Schizosaccharomyces pombe upon Glucose Starvation.
Starvation
Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2.
Starvation
Cyclic AMP-dependent protein kinase in mammary tissue of the lactating rat. Activity ratio and responsiveness of the target enzymes acetyl-CoA carboxylase and glycogen phosphorylase to beta-adrenergic stimulation.
Starvation
DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR1.
Starvation
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.
Starvation
Early post-hatching starvation delays p70 S6 kinase activation in the muscle of neonatal chicks.
Starvation
Effect of starvation, diabetes and insulin on the casein kinase 2 from rat liver cytosol.
Starvation
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
Starvation
Enhanced expression of a calcium-dependent protein kinase from the moss Funaria hygrometrica under nutritional starvation.
Starvation
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways.
Starvation
Fatty acid and retinoid binding proteins have distinct binding pockets for the two types of cargo.
Starvation
Galectin-3 Enhances Migration of Minature Pig Bone Marrow Mesenchymal Stem Cells Through Inhibition of RhoA-GTP Activity.
Starvation
GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration.
Starvation
GCN2, an old dog with new tricks.
Starvation
Glucose deprivation induced upregulation of phosphoenolpyruvate carboxykinase modulates virulence in Leishmania donovani.
Starvation
GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death.
Starvation
Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways.
Starvation
Herpes simplex virus type 1 latency-associated transcript inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels.
Starvation
How do sugars regulate plant growth and development? New insight into the role of trehalose-6-phosphate.
Starvation
Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of ?-mannosidase under nitrogen starvation conditions.
Starvation
Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans.
Starvation
IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation.
Starvation
Inhibition of cellular growth by increased guanine nucleotide pools. Characterization of an Escherichia coli mutant with a guanosine kinase that is insensitive to feedback inhibition by GTP.
Starvation
Interaction of the WD40 domain of a myoinositol polyphosphate 5-phosphatase with SnRK1 links inositol, sugar, and stress signaling.
Starvation
Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
Starvation
Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84.
Starvation
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.
Starvation
MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4.
Starvation
Mitochondrial elongation-mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress.
Starvation
Molecular cloning and cellular distribution of two 14-3-3 isoforms from Hydra: 14-3-3 proteins respond to starvation and bind to phosphorylated targets.
Starvation
mTOR Signaling, Function, Novel Inhibitors, and Therapeutic Targets.
Starvation
Multinuclear giant cell formation is enhanced by down-regulation of Wnt signaling in gastric cancer cell line, AGS.
Starvation
p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes.
Starvation
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Starvation
Phosphatase targets in TOR signaling.
Starvation
Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria.
Starvation
PI3K/Akt and MAPK pathways evoke activation of FoxO transcription factor to undergo neuronal apoptosis in brain of the silkworm Bombyx mori (Lepidoptera: Bombycidae).
Starvation
Pim family kinases enhance tumor growth of prostate cancer cells.
Starvation
pkn22 (alr2502) encoding a putative Ser/Thr kinase in the cyanobacterium Anabaena sp. PCC 7120 is induced by both iron starvation and oxidative stress and regulates the expression of isiA.
Starvation
Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis.
Starvation
Protein kinase A regulates gene-specific translational adaptation in differentiating yeast.
Starvation
Raf-1 protein expression in human breast cancer cells.
Starvation
Regulation of eukaryotic translation initiation factor 6 dynamics through multisite phosphorylation by GSK3.
Starvation
Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells.
Starvation
Selective 14-3-3? Upregulation Promotes Beclin-1-LC3-Autophagic Influx via ?-Catenin Interaction in Starved Neurons In Vitro and In Vivo.
Starvation
Serine/Threonine Kinase Pim-2 Promotes Liver Tumorigenesis Induction Through Mediating Survival and Preventing Apoptosis of Liver Cell.
Starvation
Sip2p and its partner snf1p kinase affect aging in S. cerevisiae.
Starvation
SNF1-related protein kinase 1: the many-faced signaling hub regulating developmental plasticity in plants.
Starvation
SnRK1 Isoforms AKIN10 and AKIN11 Are Differentially Regulated in Arabidopsis Plants under Phosphate Starvation.
Starvation
SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants.
Starvation
SnRK1A-Interacting Negative Regulators Modulate the Nutrient Starvation Signaling Sensor SnRK1 in Source-Sink Communication in Cereal Seedlings under Abiotic Stress.
Starvation
Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity.
Starvation
Sul1 and Sul2 Sulfate Transceptors Signal to Protein Kinase A upon Exit of Sulfur Starvation.
Starvation
Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.
Starvation
SWATH-MS quantitative proteomic investigation of nitrogen starvation in Arabidopsis reveals new aspects of plant nitrogen stress responses.
Starvation
The autophagy-related gene Acatg1 is involved in conidiation and cephalosporin production in Acremonium chrysogenum.
Starvation
The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis.
Starvation
The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males.
Starvation
The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy.
Starvation
The hprK gene of Enterococcus faecalis encodes a novel bifunctional enzyme: the HPr kinase/phosphatase.
Starvation
The hybrid four-CBS-domain KIN?? subunit functions as the canonical ? subunit of the plant energy sensor SnRK1.
Starvation
The Pkn22 Ser/Thr kinase in Nostoc PCC 7120: role of FurA and NtcA regulators and transcript profiling under nitrogen starvation and oxidative stress.
Starvation
The regulation of autophagy by calcium signals: Do we have a consensus?
Starvation
The role of PKN in the regulation of alphaB-crystallin expression via heat shock transcription factor 1.
Starvation
The trehalose-6-phosphate phosphatase Tps2 regulates ATG8 transcription and autophagy in Saccharomyces cerevisiae.
Starvation
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.
Starvation
Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.
Starvation
ULK1 cycling: The ups and downs of the autophagy response.
Starvation
ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.
Starvation
ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction.
Starvation
Unexpected link between metal ion deficiency and autophagy in Aspergillus fumigatus.
Status Epilepticus
A mechanism for the inactivation of Ca2+/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo.
Status Epilepticus
Akt Inhibitor Perifosine Prevents Epileptogenesis in a Rat Model of Temporal Lobe Epilepsy.
Status Epilepticus
Bi-directional genetic modulation of GSK-3? exacerbates hippocampal neuropathology in experimental status epilepticus.
Status Epilepticus
c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus.
Status Epilepticus
Prolonged seizure activity leads to increased Protein Kinase A activation in the rat pilocarpine model of status epilepticus.
Status Epilepticus
Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.
Status Epilepticus
[Effect of recombinant human erythropoietin on hippocampal p-Akt and caspase-9 expressions in rats with status epilepticus and the mechanism]
Stomach Diseases
Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori.
Stomach Neoplasms
12-O-tetradecanoylphorbol-1, 3-acetate induces the negative regulation of protein kinase B by protein kinase Calpha during gastric cancer cell apoptosis.
Stomach Neoplasms
12-O-tetradecanoylphorbol-1,3-acetate-induced degradation of protein kinase B via ubiquitin- -proteasomal pathway depends on its Ser473 phosphorylation in gastric cancer cells.
Stomach Neoplasms
14-3-3 sigma and p53 expression in gastric cancer and its clinical applications.
Stomach Neoplasms
14-3-3? is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer.
Stomach Neoplasms
2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer.
Stomach Neoplasms
3-Phosphoinositide Dependent Protein Kinase-1 (PDK-1) Promotes Migration and Invasion in Gastric Cancer Cells Through Activating the NF-?B Pathway.
Stomach Neoplasms
A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer.
Stomach Neoplasms
A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells.
Stomach Neoplasms
A-kinase anchoring protein 12 regulates the completion of cytokinesis.
Stomach Neoplasms
Aberrant DNA-PKcs and ERGIC1 expression may be involved in initiation of gastric cancer.
Stomach Neoplasms
Absence of mutations in the analysis of coding sequences of the entire transforming growth factor-beta type II receptor gene in sporadic human breast cancers.
Stomach Neoplasms
Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer.
Stomach Neoplasms
Adenovirus-mediated TIPE2 overexpression inhibits gastric cancer metastasis via reversal of epithelial-mesenchymal transition.
Stomach Neoplasms
alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner.
Stomach Neoplasms
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
Stomach Neoplasms
Analysis of correlation between HP infection and activation of PI3K/Akt pathway in mucosal tissues of gastric cancer and precancerous lesions.
Stomach Neoplasms
Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer.
Stomach Neoplasms
Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.
Stomach Neoplasms
Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases.
Stomach Neoplasms
ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis.
Stomach Neoplasms
Association Between Cyclin D1 Polymorphism with CpG Island Promoter Methylation Status of Tumor Suppressor Genes in Gastric Cancer.
Stomach Neoplasms
Association of serine/threonine kinase 11 mutations and response to programmed cell death 1 inhibitors in metastatic gastric cancer.
Stomach Neoplasms
AT13148, a first-in-class multi-AGC kinase inhibitor, potently inhibits gastric cancer cells both in vitro and in vivo.
Stomach Neoplasms
Autoantibody against 14-3-3 zeta: a serological marker in detection of gastric cancer.
Stomach Neoplasms
Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer.
Stomach Neoplasms
BUB1 promotes proliferation of liver cancer cells by activating SMAD2 phosphorylation.
Stomach Neoplasms
c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer.
Stomach Neoplasms
c-Jun N-terminal kinase is required for thermotherapy-induced apoptosis in human gastric cancer cells.
Stomach Neoplasms
c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells.
Stomach Neoplasms
C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits.
Stomach Neoplasms
Calcium/calmodulin?dependent protein kinase II enhances metastasis of human gastric cancer by upregulating nuclear factor??B and Akt?mediated matrix metalloproteinase?9 production.
Stomach Neoplasms
Casein kinase 2 inhibitor CX-4945 elicits an anti-Warburg effects through the downregulation of TAp73 and inhibits gastric tumorigenesis.
Stomach Neoplasms
Casein Kinase 2 Inhibitor, CX-4945, as a Potential Targeted Anticancer Agent in Gastric Cancer.
Stomach Neoplasms
Casein kinase 2 interacting protein 1 positively regulates caudal-related homeobox 1 in intestinal-type gastric cancer.
Stomach Neoplasms
CDK5RAP3 suppresses Wnt/?-catenin signaling by inhibiting AKT phosphorylation in gastric cancer.
Stomach Neoplasms
Changes in Myostatin Signaling in Non-Weight-Losing Cancer Patients.
Stomach Neoplasms
Clinical implication of 14-3-3 epsilon expression in gastric cancer.
Stomach Neoplasms
Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing.
Stomach Neoplasms
Clinical significance of PI3K/Akt/mTOR signaling in gastric carcinoma.
Stomach Neoplasms
Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110? Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers.
Stomach Neoplasms
Compare the Effects of Magnolol on Gastric Cancer Cells Through c-Jun N-Terminal Kinase Signaling Pathway and Gold Magnetic.
Stomach Neoplasms
Constitutive activation of glycogen synthase kinase-3beta correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer.
Stomach Neoplasms
Copy-number increase of AURKA in gastric cancers in a Chinese population: a correlation with tumor progression.
Stomach Neoplasms
Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line.
Stomach Neoplasms
Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma.
Stomach Neoplasms
Differential expression of HER2 and downstream proteins in prediction of advanced tumor phenotypes and overall survival of patients with Epstein-Barr virus-positive vs. negative gastric cancers.
Stomach Neoplasms
Down-Regulation of circNRIP1 Promotes the Apoptosis and Inhibits the Migration and Invasion of Gastric Cancer Cells by miR-182/ROCK1 Axis.
Stomach Neoplasms
Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway.
Stomach Neoplasms
Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1.
Stomach Neoplasms
Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer.
Stomach Neoplasms
Effect of EGFR and p-AKT Overexpression on Chromosomal Instability in Gastric Cancer.
Stomach Neoplasms
Elevated microRNA-7 inhibits proliferation and tumor angiogenesis and promotes apoptosis of gastric cancer cells via repression of Raf-1.
Stomach Neoplasms
Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells.
Stomach Neoplasms
Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion.
Stomach Neoplasms
Epithelial-mesenchymal transition in gastric cancer (Review).
Stomach Neoplasms
Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma.
Stomach Neoplasms
Expression of Concern: Elevated microRNA-7 inhibits proliferation and tumor angiogenesis and promotes apoptosis of gastric cancer cells via repression of Raf-1.
Stomach Neoplasms
Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells.
Stomach Neoplasms
Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis.
Stomach Neoplasms
Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability.
Stomach Neoplasms
Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer.
Stomach Neoplasms
Geldanamycin induces apoptosis in human gastric carcinomas by affecting multiple oncogenic kinases that have synergic effects with TNF-related apoptosis-inducing ligand.
Stomach Neoplasms
Gene amplification of ribosomal protein s6 kinase-1 and -2 in gastric cancer.
Stomach Neoplasms
Genetic testing by cancer site: stomach.
Stomach Neoplasms
Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the ?-Catenin/TCF/LEF-1 pathway in gastric cancer cells.
Stomach Neoplasms
Glycogen Synthase Kinase-3beta regulates Snail and beta-catenin during gastrin-induced migration of gastric cancer cells.
Stomach Neoplasms
Helicobacter pylori induces cell migration and invasion through casein kinase 2 in gastric epithelial cells.
Stomach Neoplasms
Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo(-/-) mice.
Stomach Neoplasms
Helicobacter pylori infection of gastric cancer cells elevates the level of expression and activation of protein kinase d2.
Stomach Neoplasms
HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer.
Stomach Neoplasms
High expression of integrin-linked kinase predicts aggressiveness and poor prognosis in patients with gastric cancer.
Stomach Neoplasms
High expression of PFTK1 in cancer cells predicts poor prognosis in colorectal cancer.
Stomach Neoplasms
HSP90 inhibitor, AUY922, debilitates intrinsic and acquired lapatinib-resistant HER2-positive gastric cancer cells.
Stomach Neoplasms
Immunohistochemical detection of the Raf kinase inhibitor protein in nonneoplastic gastric tissue and gastric cancer tissue.
Stomach Neoplasms
Inhibiting casein kinase 2 overcomes paclitaxel resistance in gastric cancer.
Stomach Neoplasms
Inhibition of gastric cancer angiogenesis by vector-based RNA interference for Raf-1.
Stomach Neoplasms
Inhibitory effect of Polo-like kinase 1 depletion on mitosis and apoptosis of gastric cancer cells.
Stomach Neoplasms
Iron chelator-induced apoptosis via the ER stress pathway in gastric cancer cells.
Stomach Neoplasms
Kir2.1 interaction with Stk38 promotes invasion and metastasis of human gastric cancer by enhancing MEKK2-MEK1/2-ERK1/2 signaling.
Stomach Neoplasms
Knockdown of A-kinase anchor protein 4 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/?-catenin pathway in human gastric cancer cells.
Stomach Neoplasms
Knockdown of Microtubule Associated Serine/threonine Kinase Like Expression Inhibits Gastric Cancer Cell Growth and Induces Apoptosis by Activation of ERK1/2 and Inactivation of NF-?B Signaling.
Stomach Neoplasms
Knockdown of RIPK2 Inhibits Proliferation and Migration, and Induces Apoptosis via the NF-?B Signaling Pathway in Gastric Cancer.
Stomach Neoplasms
Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model.
Stomach Neoplasms
Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.
Stomach Neoplasms
LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies.
Stomach Neoplasms
LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells.
Stomach Neoplasms
LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target.
Stomach Neoplasms
Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers.
Stomach Neoplasms
Low STYK1 expression indicates poor prognosis in gastric cancer.
Stomach Neoplasms
LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells.
Stomach Neoplasms
Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis.
Stomach Neoplasms
Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line.
Stomach Neoplasms
MicroRNA 135a Suppresses Lymph Node Metastasis through Down-Regulation of ROCK1 in Early Gastric Cancer.
Stomach Neoplasms
microRNA-133a Inhibits Proliferation of Gastric Cancer Cells By Downregulating ERBB2 Expression.
Stomach Neoplasms
MicroRNA-139 inhibits the proliferation, migration and invasion of gastric cancer cells by directly targeting ?-associated protein kinase 1.
Stomach Neoplasms
MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer.
Stomach Neoplasms
MicroRNA-222-3p associated with Helicobacter pylori targets HIPK2 to promote cell proliferation, invasion, and inhibits apoptosis in gastric cancer.
Stomach Neoplasms
Midkine confers Adriamycin resistance in human gastric cancer cells.
Stomach Neoplasms
miR-124 inhibits growth and invasion of gastric cancer by targeting ROCK1.
Stomach Neoplasms
miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2.
Stomach Neoplasms
MiR-203 inhibits tumor invasion and metastasis in gastric cancer by ATM.
Stomach Neoplasms
miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway.
Stomach Neoplasms
MK-2206, an Akt inhibitor, enhances carboplatinum/paclitaxel efficacy in gastric cancer cell lines.
Stomach Neoplasms
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Stomach Neoplasms
Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer.
Stomach Neoplasms
Mutation analysis of the transforming growth factor-beta type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-beta.
Stomach Neoplasms
Mutation at intronic repeats of the ataxia-telangiectasia mutated (ATM) gene and ATM protein loss in primary gastric cancer with microsatellite instability.
Stomach Neoplasms
Mutations in STK11 gene in Czech Peutz-Jeghers patients.
Stomach Neoplasms
Notch1 and PI3K/Akt signaling blockers DAPT and LY294002 coordinately inhibit metastasis of gastric cancer through mutual enhancement.
Stomach Neoplasms
Novel tertiary sulfonamide derivatives containing benzimidazole moiety as potent anti-gastric cancer agents: Design, synthesis and SAR studies.
Stomach Neoplasms
Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have progressed following first-line therapy (GOLD): a double-blind, randomised, placebo-controlled, phase 3 trial.
Stomach Neoplasms
ONECUT2 Accelerates Tumor Proliferation Through Activating ROCK1 Expression in Gastric Cancer.
Stomach Neoplasms
p-Akt as a potential poor prognostic factor for gastric cancer: a systematic review and meta-analysis.
Stomach Neoplasms
p120-catenin participates in the progress of gastric cancer through regulating the Rac1 and Pak1 signaling pathway.
Stomach Neoplasms
P21-activated kinase 4 overexpression in metastatic gastric cancer patients.
Stomach Neoplasms
P27Kip1, regulated by glycogen synthase kinase-3beta, results in HMBA-induced differentiation of human gastric cancer cells.
Stomach Neoplasms
PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion.
Stomach Neoplasms
PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/Erk-dependent pathways.
Stomach Neoplasms
PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis.
Stomach Neoplasms
Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells.
Stomach Neoplasms
Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax.
Stomach Neoplasms
PRL-3 promotes gastric cancer peritoneal metastasis via the PI3K/AKT signaling pathway in vitro and in vivo.
Stomach Neoplasms
Proapoptotic and Growth-inhibitory Effects of Plumbagin on Human Gastric Cancer Cells Via Suppression of Signal Transducer and Activator of Transcription 3 and Protein Kinase B.
Stomach Neoplasms
Procyanidin B2 induces apoptosis and autophagy in gastric cancer cells by inhibiting Akt/mTOR signaling pathway.
Stomach Neoplasms
Prognostic value of RKIP and p-ERK in gastric cancer.
Stomach Neoplasms
Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer.
Stomach Neoplasms
Promoter methylation status of DAP-kinase and RUNX3 genes in neoplastic and non-neoplastic gastric epithelia.
Stomach Neoplasms
Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail.
Stomach Neoplasms
Protein-tyrosine kinase and protein-serine/threonine kinase expression in human gastric cancer cell lines.
Stomach Neoplasms
PTEN Gene Induces Cell Invasion and Migration via Regulating AKT/GSK-3?/?-Catenin Signaling Pathway in Human Gastric Cancer.
Stomach Neoplasms
Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer.
Stomach Neoplasms
Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.
Stomach Neoplasms
Reduction of miR?132?3p contributes to gastric cancer proliferation by targeting MUC13.
Stomach Neoplasms
Regenerating gene family member 4 promotes growth and migration of gastric cancer through protein kinase B pathway.
Stomach Neoplasms
Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.
Stomach Neoplasms
Reversal of cisplatin resistance in human gastric cancer cells by a wogonin-conjugated Pt(IV) prodrug via attenuating Casein Kinase 2-mediated Nuclear Factor-?B pathways.
Stomach Neoplasms
RKIP expression associated with gastric cancer cell invasion and metastasis.
Stomach Neoplasms
RKIP inhibits gastric cancer cell survival and invasion by regulating the expression of HMGA2 and OPN.
Stomach Neoplasms
RKIP promotes cisplatin-induced gastric cancer cell death through NF-?B/Snail pathway.
Stomach Neoplasms
RKIP suppresses gastric cancer cell proliferation and invasion and enhances apoptosis regulated by microRNA-224.
Stomach Neoplasms
RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer.
Stomach Neoplasms
RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer.
Stomach Neoplasms
Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer.
Stomach Neoplasms
Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA.
Stomach Neoplasms
Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k-Akt signaling pathway.
Stomach Neoplasms
Structure of the activated c-raf-1 gene from human stomach cancer.
Stomach Neoplasms
Targeting AKT protein kinase in gastric cancer.
Stomach Neoplasms
The aurora kinase A regulates GSK-3beta in gastric cancer cells.
Stomach Neoplasms
The clinical implication of 14-3-3 sigma expression in primary gastrointestinal malignancy.
Stomach Neoplasms
The compound 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via reactive oxygen species-regulated mitogen-activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gastric cancer cells.
Stomach Neoplasms
The differential proteome profile of stomach cancer: identification of the biomarker candidates.
Stomach Neoplasms
The expression of protein kinase B in gastric cancer cell apoptosis induced by 12-O-tetradecanoylphorbol-1, 3-acetate.
Stomach Neoplasms
The survival analysis and oncogenic effects of CFP1 and 14-3-3 expression on gastric cancer.
Stomach Neoplasms
The Wnt/?-catenin and PI3K/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation.
Stomach Neoplasms
Transcriptome Analysis of the Inhibitory Effect of Astaxanthin on Helicobacter pylori-Induced Gastric Carcinoma Cell Motility.
Stomach Neoplasms
Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases.
Stomach Neoplasms
Upregulation of ECT2 is associated with transcriptional program of cancer stem cells and predicts poor clinical outcome in gastric cancer.
Stomach Neoplasms
Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1.
Stomach Neoplasms
Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and ?-H2A.X phosphorylation.
Stomach Neoplasms
[Activated c-raf-1 gene from human stomach cancer]
Stomach Neoplasms
[Inhibition of serine/threonine kinase 15 gene expression induces apoptosis of gastric cancer cells]
Stomach Neoplasms
[Jaridonin, a new diterpenoid from Isodon rubescens, induces cell cycle arrest in gastric cancer cells through activating ataxia telangiectasia mutated kinase].
Stomach Neoplasms
[Nimesulide, a selective cyclooxygenase-2 inhibitor inhibits telomerase activity by blocking activation of PKB in gastric cancer cell line]
Stomach Neoplasms
[Overexpression of 14-3-3 in primary gastric cancers and clinical application for the detection of micrometastases in the peritoneal cavity]
Stomach Neoplasms
[Protein kinase B inhibitor enhance sensitivity of gastric cancer cell to etoposide]
Stomach Neoplasms
[Screening of novel biomarkers for the detection of intraperitoneally disseminated cancer cells using human cDNA microarray]
Stomach Ulcer
Activation of Raf-1 during experimental gastric ulcer healing is Ras-mediated and protein kinase C-independent.
Stomach Ulcer
Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion and restraint stress-induced gastric ulcers in rats.
Stomatitis
Acute oral mucositis in nasopharyngeal carcinoma patients treated with radiotherapy: Association with genetic polymorphism in DNA DSB repair genes.
Strabismus
DAnkrd49 and Bdbt act via Casein kinase I? to regulate planar polarity in Drosophila.
Strabismus
Reciprocal action of Casein Kinase I? on core planar polarity proteins regulates clustering and asymmetric localisation.
Streptococcal Infections
Regulatory Role of GSK-3 ? on NF- ? B, Nitric Oxide, and TNF- ? in Group A Streptococcal Infection.
Stroke
14-3-3 Isoforms Differentially Regulate NF?B Signaling in the Brain After Ischemia-Reperfusion.
Stroke
14-3-3 proteins in neurodegeneration.
Stroke
5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.
Stroke
Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats.
Stroke
Age-related changes in glycogen synthase kinase 3beta (GSK3beta) immunoreactivity in the central nervous system of rats.
Stroke
AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.
Stroke
Akt1 gene deletion and stroke.
Stroke
Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models.
Stroke
Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke.
Stroke
Bone Marrow Mononuclear Cells Transplantation and Training Increased Transplantation of Energy Source Transporters in Chronic Stroke.
Stroke
C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
Stroke
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Stroke
CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1.
Stroke
Combined ampakine and BDNF treatments enhance poststroke functional recovery in aged mice via AKT-CREB signaling.
Stroke
Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats.
Stroke
Common variants of ROCKs and the risk of hypertension, and stroke: Two case-control studies and a follow-up study in Chinese Han population.
Stroke
Cryptotanshinone exhibits therapeutical effects on cerebral stroke through the PI3K/AKT?eNOS signaling pathway.
Stroke
Delayed Activin A administration attenuates tissue death after transient focal cerebral ischemia and is associated with decreased stress-responsive kinase activation.
Stroke
Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3?.
Stroke
Differences in post-ischaemic motor recovery and angiogenesis of MCAO rats following electroacupuncture at different acupoints.
Stroke
Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin.
Stroke
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Stroke
DNA damage responses in neural cells: Focus on the telomere.
Stroke
Effective post-insult neuroprotection by a novel CaMKII inhibitor.
Stroke
Excitotoxic insult results in a long-lasting activation of CaMKII? and mitochondrial damage in living hippocampal neurons.
Stroke
Genetic Mutation of GluN2B Protects Brain Cells Against Stroke Damages.
Stroke
Ginkgetin aglycone attenuates neuroinflammation and neuronal injury in the rats with ischemic stroke by modulating STAT3/JAK2/SIRT1.
Stroke
Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation.
Stroke
Glycogen synthase kinase 3: an emerging therapeutic target.
Stroke
Glycogen synthase kinase-3 (GSK-3) inhibitors reach the clinic.
Stroke
Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking.
Stroke
Glycogen synthase kinase-3: a target for novel bipolar disorder treatments.
Stroke
GSK-3 Inhibitors: A new class of drugs for Alzheimer's Disease Treatment.
Stroke
GSK-3 inhibitors: discoveries and developments.
Stroke
GSK3beta signalling: casting a wide net in Alzheimer's disease.
Stroke
Hyperglycemia decreases expression of 14-3-3 proteins in an animal model of stroke.
Stroke
Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH.
Stroke
Identification of small molecules that inhibit GSK-3beta through virtual screening.
Stroke
Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat.
Stroke
Insight into glycogen synthase kinase-3? inhibitory activity of phyto-constituents from Melissa officinalis: in silico studies.
Stroke
Intervention of death-associated protein kinase 1-p53 interaction exerts the therapeutic effects against stroke.
Stroke
MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease.
Stroke
miR-214 Alleviates Ischemic Stroke-Induced Neuronal Death by Targeting DAPK1 in Mice.
Stroke
NADPH Oxidase-2: Linking Glucose, Acidosis, and Excitotoxicity in Stroke.
Stroke
NCX as a key player in the neuroprotection exerted by ischemic preconditioning and postconditioning.
Stroke
Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling in hypoxia/re-oxygenation.
Stroke
Power output is increased after phosphorylation of myofibrillar proteins in rat skinned cardiac myocytes.
Stroke
PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
Stroke
Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein.
Stroke
Reverse two-hybrid screening identifies residues of JNK required for interaction with the kinase interaction motif of JNK-interacting protein-1.
Stroke
Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3? inhibitors: A critical review.
Stroke
Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition.
Stroke
Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke.
Stroke
Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management.
Stroke
Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke.
Stroke
Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders.
Stroke
The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.
Stroke
The role of Ca(2+)-calmodulin stimulated protein kinase II in ischaemic stroke - A potential target for neuroprotective therapies.
Stroke
Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo.
Strongyloidiasis
Production of recombinant 14-3-3 protein and determination of its immunogenicity for application in serodiagnosis of strongyloidiasis.
Subarachnoid Hemorrhage
Activation of c-jun in the rat basilar artery after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Activation of the Protein Kinase B (Akt) Reduces Nur77-induced Apoptosis During Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rat.
Subarachnoid Hemorrhage
Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model.
Subarachnoid Hemorrhage
Etanercept Alleviates Early Brain Injury Following Experimental Subarachnoid Hemorrhage and the Possible Role of Tumor Necrosis Factor-? and c-Jun N-Terminal Kinase Pathway.
Subarachnoid Hemorrhage
Inhibition of c-Jun N-terminal kinase ameliorates early brain injury after subarachnoid hemorrhage through inhibition of a Nur77 dependent apoptosis pathway.
Subarachnoid Hemorrhage
Inhibition of c-Jun N-terminal kinase pathway attenuates cerebral vasospasm after experimental subarachnoid hemorrhage through the suppression of apoptosis.
Subarachnoid Hemorrhage
Inhibition of c-Jun N-terminal kinase prevents blood-brain barrier disruption and normalizes the expression of tight junction proteins clautin-5 and ZO-1 in a rat model of subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Inhibition of HDAC4 Attenuated JNK/c-Jun-Dependent Neuronal Apoptosis and Early Brain Injury Following Subarachnoid Hemorrhage by Transcriptionally Suppressing MKK7.
Subarachnoid Hemorrhage
Possible Role of Raf-1 Kinase in the Development of Cerebral Vasospasm and Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats.
Subarachnoid Hemorrhage
Role of c-Jun N-terminal kinase in cerebral vasospasm after experimental subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
[Effect of thyroxine on the expression of HIF-1? after aneurysmal subarachnoid hemorrhage in rat brain and its mechanism].
Sunburn
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin.
Supranuclear Palsy, Progressive
A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy.
Supranuclear Palsy, Progressive
Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease.
Supranuclear Palsy, Progressive
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Supranuclear Palsy, Progressive
Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.
Supranuclear Palsy, Progressive
Evidence for irreversible inhibition of glycogen synthase kinase-3? by tideglusib.
Supranuclear Palsy, Progressive
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.
Supranuclear Palsy, Progressive
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Supranuclear Palsy, Progressive
LRRK2 and survival in progressive supranuclear palsy.
Supranuclear Palsy, Progressive
LRRK2 p.Ile1371Val Mutation in a Case with Neuropathologically Confirmed Multi-System Atrophy.
Supranuclear Palsy, Progressive
Lrrk2 R1441 substitution and progressive supranuclear palsy.
Supranuclear Palsy, Progressive
Pharmacophore feature-based virtual screening for finding potent GSK-3 inhibitors using molecular docking and dynamics simulations.
Supranuclear Palsy, Progressive
Randomized placebo-controlled trial of sodium valproate in progressive supranuclear palsy.
Supranuclear Palsy, Progressive
Screening for LRRK2 R1441 mutations in a cohort of PSP patients from Germany.
Supranuclear Palsy, Progressive
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Supranuclear Palsy, Progressive
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration.
Supranuclear Palsy, Progressive
Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial.
Supranuclear Palsy, Progressive
[Clinical molecular genetics for PARK8 (LRRK2)]
Synucleinopathies
14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic ?-Synuclein.
Synucleinopathies
?-synuclein RT-QuIC in cerebrospinal fluid of LRRK2-linked Parkinson's disease.
Synucleinopathies
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
Synucleinopathies
High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
Synucleinopathies
How many biomarkers to discriminate neurodegenerative dementia?
Synucleinopathies
Investigation of Somatic Mutations in Human Brains Targeting Genes Associated With Parkinson's Disease.
Synucleinopathies
LRRK2 and neurodegeneration.
Synucleinopathies
LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease.
Synucleinopathies
Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease.
Synucleinopathies
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.
Synucleinopathies
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications.
Synucleinopathies
Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out.
Synucleinopathies
Papp-Lantos inclusions and the pathogenesis of multiple system atrophy: an update.
Synucleinopathies
Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants.
Synucleinopathies
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Synucleinopathies
[Clinical molecular genetics for PARK8 (LRRK2)]
Tachycardia
Conduction in the right and left ventricle is differentially regulated by protein kinases and phosphatases: implications for arrhythmogenesis.
Tachycardia
Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes.
Tachycardia, Ventricular
Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions.
Tachycardia, Ventricular
Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.
Tachycardia, Ventricular
CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia.
Tachycardia, Ventricular
Cardioprotective role of GTS-21 by attenuating the TLR4/NF-?B pathway in streptozotocin-induced diabetic cardiomyopathy in rats.
Tachycardia, Ventricular
Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.
Tachycardia, Ventricular
Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits.
Tachycardia, Ventricular
The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet.
Takayasu Arteritis
Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.
Tardive Dyskinesia
Genetic association of BDNF val66met and GSK-3beta-50T/C polymorphisms with tardive dyskinesia.
Tauopathies
A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice.
Tauopathies
Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice.
Tauopathies
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.
Tauopathies
Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy.
Tauopathies
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.
Tauopathies
Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.
Tauopathies
Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice.
Tauopathies
Cognitive effects of the GSK-3 inhibitor "lithium" in LPS/chronic mild stress rat model of depression: Hippocampal and cortical neuroinflammation and tauopathy.
Tauopathies
Cognitive enhancement, TAU phosphorylation reduction, and neuronal protection by the treatment of an LRRK2 inhibitor in a tauopathy mouse model.
Tauopathies
Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration.
Tauopathies
Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies.
Tauopathies
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Tauopathies
Differential effects of 14-3-3 dimers on Tau phosphorylation, stability and toxicity in vivo.
Tauopathies
Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein.
Tauopathies
Effects of Thioflavin T and GSK-3 Inhibition on Lifespan and Motility in a Caenorhabditis elegans Model of Tauopathy.
Tauopathies
Efficacy of a novel, orally active GSK-3 inhibitor 6-Methyl-N-[3-[[3-(1-methylethoxy)propyl]carbamoyl]-1H-pyrazol-4-yl]pyridine-3-carboxamide in tau transgenic mice.
Tauopathies
Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond.
Tauopathies
G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.
Tauopathies
Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study.
Tauopathies
Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.
Tauopathies
GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila.
Tauopathies
Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.
Tauopathies
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo.
Tauopathies
Inhibition of glycogen synthase kinase-3: an emerging target in the treatment of traumatic brain injury.
Tauopathies
Inhibition of proteasome and Shaggy/Glycogen synthase kinase-3beta kinase prevents clearance of phosphorylated tau in Drosophila.
Tauopathies
Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
Tauopathies
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Tauopathies
Lithium, a potential protective drug in Alzheimer's disease.
Tauopathies
Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion.
Tauopathies
LRRK2 and neurodegeneration.
Tauopathies
LRRK2 phosphorylates novel tau epitopes and promotes tauopathy.
Tauopathies
Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.
Tauopathies
Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.
Tauopathies
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Tauopathies
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Tauopathies
Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice.
Tauopathies
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Tauopathies
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration.
Tauopathies
Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.
Tauopathies
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain.
Tauopathies
The Stress c-Jun N-terminal Kinase Signaling Pathway Activation Correlates with Synaptic Pathology and Presents A Sex Bias in P301L Mouse Model of Tauopathy.
Tauopathies
Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation.
Tauopathies
Zeta 14-3-3 protein favours the formation of human tau fibrillar polymers.
Tauopathies
[Clinical molecular genetics for PARK8 (LRRK2)]
TDP-43 Proteinopathies
Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.
TDP-43 Proteinopathies
First Japanese autopsy case showing LRRK2 mutation G2019S and TDP-43 proteinopathy.
Telangiectasia, Hereditary Hemorrhagic
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Telangiectasia, Hereditary Hemorrhagic
Variation in Telangiectasia Predisposing Genes Is Associated With Overall Radiation Toxicity.
Telangiectasia, Hereditary Hemorrhagic
[Analysis of genetic mutation and modifier genes in pulmonary arterial hypertension]
Telangiectasis
A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status.
Telangiectasis
Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.
Telangiectasis
Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage.
Telangiectasis
Allogeneic Stem Cell Transplantation after Fanconi Anemia Conditioning in Children with Ataxia-Telangiectasia Results in Stable T Cell Engraftment and Lack of Infections despite Mixed Chimerism.
Telangiectasis
Cerebral Abnormalities in Adults with Ataxia-Telangiectasia.
Telangiectasis
Cutaneous Granulomatosis and Class Switching Defect as a Presenting Sign in Ataxia-Telangiectasia: First Case from the National Iranian Registry and Review of the Literature.
Telangiectasis
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Telangiectasis
DNA damage signaling in the cellular responses to mustard vesicants.
Telangiectasis
DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.
Telangiectasis
Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.
Telangiectasis
EBV encoded miRNA BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway.
Telangiectasis
Elongated telomeres in scid mice.
Telangiectasis
Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Telangiectasis
Gallic acid induces DNA damage and inhibits DNA repair-associated protein expression in human oral cancer SCC-4 cells.
Telangiectasis
In Vitro Analysis of the Role of RPA and RPA Phosphorylation in ATR-Mediated Checkpoint Signaling.
Telangiectasis
Inactivation of mTor arrests bovine oocytes in the metaphase-I stage, despite reversible inhibition of 4E-BP1 phosphorylation.
Telangiectasis
L-carnitine enhances resistance to oxidative stress by reducing DNA damage in Ataxia telangiectasia cells.
Telangiectasis
Multiple roles for MRE11 at uncapped telomeres.
Telangiectasis
N-hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells.
Telangiectasis
P65-mediated miR-590 inhibition modulates the chemoresistance of osteosarcoma to doxorubicin through targeting wild-type p53-induced phosphatase 1.
Telangiectasis
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Telangiectasis
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Telangiectasis
Rejuvenating Bi(d)ology.
Telangiectasis
SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes.
Telangiectasis
Ursolic Acid-Regulated Energy Metabolism-Reliever or Propeller of Ultraviolet-Induced Oxidative Stress and DNA Damage?
Telangiectasis
Variation in Telangiectasia Predisposing Genes Is Associated With Overall Radiation Toxicity.
Telangiectasis
[Analysis of genetic mutation and modifier genes in pulmonary arterial hypertension]
Temporomandibular Joint Disorders
Central Role of Protein Kinase A in Promoting Trigeminal Nociception in an In Vivo Model of Temporomandibular Disorders.
Temporomandibular Joint Disorders
Enriched Chicken Bone Broth as a Dietary Supplement Reduces Nociception and Sensitization Associated with Prolonged Jaw Opening.
Tendinopathy
Targeting the NF-?B signaling pathway in chronic tendon disease.
Teratocarcinoma
Abundance, complexation, and trafficking of Wnt/beta-catenin signaling elements in response to Wnt3.
Teratocarcinoma
Characterization of protein kinase CK2 protein subunits and p53 in F9 teratocarcinoma cells in the absence and presence of cisplatin.
Teratocarcinoma
Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells.
Teratocarcinoma
In situ hybridization analysis of ZPK gene expression during murine embryogenesis.
Teratocarcinoma
Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line.
Teratocarcinoma
MPK38 expression is upregulated in immature T cells activated by concanavalin A.
Teratocarcinoma
p53 and the ribosomal protein L5 participate in high molecular mass complex formation with protein kinase CK2 in murine teratocarcinoma cell line F9 after serum stimulation and cisplatin treatment.
Teratocarcinoma
Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation.
Teratocarcinoma
Retinoic acid stimulates protein kinase A-associated G proteins during human teratocarcinoma differentiation.
Teratocarcinoma
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.
Teratoma
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Teratoma
A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status.
Teratozoospermia
Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit.
Teratozoospermia
PICK1 deficiency causes male infertility in mice by disrupting acrosome formation.
Teratozoospermia
Profiling signaling proteins in human spermatozoa: biomarker identification for sperm quality evaluation.
Teratozoospermia
Search for mutations involved in human globozoospermia.
Teratozoospermia
Searching for candidate genes for male infertility.
Testicular Neoplasms
Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3.
Testicular Neoplasms
MK2206 Enhances Cisplatin-Induced Cytotoxicity and Apoptosis in Testicular Cancer Through Akt Signaling Pathway Inhibition.
Testicular Neoplasms
Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells.
Testicular Neoplasms
[Peutz-Jeghers syndrome : Not only a polyposis!]
Tetanus
Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation.
Tetanus
Domoic acid induces a long-lasting enhancement of CA1 field responses and impairs tetanus-induced long-term potentiation in rat hippocampal slices.
Tetanus
Models of calmodulin trapping and CaM kinase II activation in a dendritic spine.
Tetanus
Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons.
Tetanus
Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons.
Tetanus
Transport of AMPA receptors during long-term potentiation is impaired in rats with hepatic encephalopathy.
Tetanus
Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus.
Tetralogy of Fallot
Low-frequency intermediate penetrance variants in the ROCK1 gene predispose to Tetralogy of Fallot.
Tetralogy of Fallot
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Thecoma
14-3-3 sigma is a useful immunohistochemical marker for diagnosing ovarian granulosa cell tumors and steroid cell tumors.
Thecoma
Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors?
Theileriasis
Assignment of the casein kinase II gene family to cattle chromosomes.
Theileriasis
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle.
Theileriasis
Casein kinase II in theileriosis.
Thrombasthenia
Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia.
Thrombocytopenia
Prediction of the post-translational modification sites on dengue virus E protein and deciphering their role in pathogenesis.
Thrombocytopenia
Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeleton dynamics in platelets.
Thromboinflammation
Ser/Thr protein kinase B?-NADPH oxidase 2 signaling in thromboinflammation.
Thrombophilia
A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant.
Thrombosis
14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.
Thrombosis
Co-Upregulation of 14-3-3? and P-Akt is Associated with Oncogenesis and Recurrence of Hepatocellular Carcinoma.
Thrombosis
Differential Phosphoinositide 3-Kinase Signaling: Implications for PTCA?
Thrombosis
Function of protein kinase CK2 in thrombus formation.
Thrombosis
GSK3beta is a negative regulator of platelet function and thrombosis.
Thrombosis
Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Förster resonance energy transfer.
Thrombosis
PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.
Thrombosis
Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.
Thrombosis
Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol 3-kinase/Akt-dependent heat-shock protein/endothelial nitric oxide synthase signaling.
Thrombosis
Role of protein kinase CK2 in the dynamic interaction of platelets, leukocytes and endothelial cells during thrombus formation.
Thrombosis
RXR Ligands Negatively Regulate Thrombosis and Hemostasis.
Thrombosis
Selective Biligand Inhibitor of CK2 Increases Caspase-3 Activity in Cancerous Cells and Inhibits Platelet Aggregation.
Thrombotic Microangiopathies
STK11 loss drives rapid progression in a breast cancer patient resulting in pulmonary tumor thrombotic microangiopathy.
Thymoma
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis.
Thymoma
A20 Inhibits ?-Cell Apoptosis by Multiple Mechanisms and Predicts Residual ?-Cell Function in Type 1 Diabetes.
Thymoma
Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals.
Thymoma
AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells.
Thymoma
Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt.
Thymoma
Astaxanthin Modulation of Signaling Pathways That Regulate Autophagy.
Thymoma
Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics.
Thymoma
BTB and CNC homology 1 inhibition ameliorates fibrosis and inflammation via blocking ERK pathway in pulmonary fibrosis.
Thymoma
cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Thymoma
Correction of DNA Protein Kinase Deficiency by Spliceosome-mediated RNA Trans-splicing and Sleeping Beauty Transposon Delivery.
Thymoma
Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.
Thymoma
Dimerumic Acid and Deferricoprogen Activate Ak Mouse Strain Thymoma/Heme Oxygenase-1 Pathways and Prevent Apoptotic Cell Death in 6-Hydroxydopamine-Induced SH-SY5Y Cells.
Thymoma
Effects of low-level laser irradiation on mesenchymal stem cell proliferation: a microarray analysis.
Thymoma
Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer.
Thymoma
Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia.
Thymoma
Family of peptides synthesized in the human body have anticancer effects.
Thymoma
Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways.
Thymoma
Genome-wide analysis of murine bone marrow?derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells.
Thymoma
Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats.
Thymoma
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Thymoma
Heat induces myogenic transcription factors of myoblast cells via transient receptor potential vanilloid 1 (Trpv1).
Thymoma
Hepatic insulin-like growth factor receptor is upregulated by activation of the GSK3B-FOXO3 pathway after partial hepatectomy.
Thymoma
Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis.
Thymoma
Identification of high-affinity phorbol ester receptor in cytosol of EL4 thymoma cells: requirement for calcium, magnesium, and phospholipids.
Thymoma
In Vitro Functional Correction of the Mutation Responsible for Murine Severe Combined Immune Deficiency by Small Fragment Homologous Replacement.
Thymoma
In vitro functional correction of the mutation responsible for murine severe combined immune deficiency by small fragment homologous replacement.
Thymoma
Insulin signaling in mouse oocytes.
Thymoma
Lack of association between AKT1 variances versus clinical manifestations and social function in patients with schizophrenia.
Thymoma
Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease.
Thymoma
Molecular Profiling of Thymoma and Thymic Carcinoma: Genetic Differences and Potential Novel Therapeutic Targets.
Thymoma
New function of type I IFN: induction of autophagy.
Thymoma
Nicotine-Induced Structural Plasticity in Mesencephalic Dopaminergic Neurons Is Mediated by Dopamine D3 Receptors and Akt-mTORC1 Signalling.
Thymoma
Overexpression of protein kinase B/AKT induces phosphorylation of p70S6K and 4E-BP1 in goat fetal fibroblasts.
Thymoma
Phenotypes of AKT3 deletion: a case report and literature review.
Thymoma
Quantitative Phosphoproteomic Analysis Reveals the Regulatory Networks of Elovl6 on Lipid and Glucose Metabolism in Zebrafish.
Thymoma
Reduction of dopamine and glycogen synthase kinase-3 signaling in rat striatum after continuous administration of haloperidol.
Thymoma
Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma.
Thymoma
Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Thymoma
Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury.
Thymoma
T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.
Thymoma
The possible role of the Akt signaling pathway in schizophrenia.
Thymoma
Transcriptome Analysis of Potential miRNA Involved in Adipogenic Differentiation of C2C12 Myoblasts.
Thymoma
Transcriptomic differences of genes in the avian target of rapamycin (avTOR) pathway in a divergent line of meat-type chickens selected for feed efficiency.
Thymoma
Wnt4 overexpression promotes thymoma development through a JNK-mediated planar cell polarity-like pathway.
Thymus Neoplasms
Insulin-like growth factor-1 receptor and phosphorylated AKT-serine 473 expression in 132 resected thymomas and thymic carcinomas.
Thyroid Cancer, Papillary
A meta-analysis evaluating the relationship between B-type Raf kinase mutation and cervical lymphatic metastasis in papillary thyroid cancer.
Thyroid Cancer, Papillary
A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
Thyroid Cancer, Papillary
A testing algorithm for detection of the B-type Raf kinase V600E mutation in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
A-kinase interacting protein 1 as a potential biomarker of advanced tumor features and increased recurrence risk in papillary thyroid carcinoma patients.
Thyroid Cancer, Papillary
Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Association analysis and the clinical significance of BRAF gene mutations and ultrasound features in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Association between BRAF(V600E) mutation and the clinicopathological features of solitary papillary thyroid microcarcinoma.
Thyroid Cancer, Papillary
B-RAF V600E mutational analysis of fine needle aspirates correlates with diagnosis of thyroid nodules.
Thyroid Cancer, Papillary
BRAF Mutation in Papillary Thyroid Cancer and Its Value in Tailoring Initial Treatment: A Systematic Review and Meta-Analysis.
Thyroid Cancer, Papillary
BRAF T1796A transversion mutation in various thyroid neoplasms.
Thyroid Cancer, Papillary
BRAF(V600E) mutation is associated with an increased risk of nodal recurrence requiring reoperative surgery in patients with papillary thyroid cancer.
Thyroid Cancer, Papillary
BRAFV600E mutation and expression of proangiogenic molecular markers in papillary thyroid carcinomas.
Thyroid Cancer, Papillary
BRAFV600E mutation, BRAF-activated long non-coding RNA and miR-9 expression in papillary thyroid carcinoma, and their association with clinicopathological features.
Thyroid Cancer, Papillary
CKS1B promotes cell proliferation and invasion by activating STAT3/PD-L1 and phosphorylation of Akt signaling in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Clinicopathological Features and Prognosis of Papillary Thyroid Microcarcinoma for Surgery and Relationships with the BRAFV600E Mutational Status and Expression of Angiogenic Factors.
Thyroid Cancer, Papillary
Correlation of BRAF mutation and SUVmax levels in thyroid cancer patients incidentally detected in (18)F-fluorodeoxyglucose positron emission tomography.
Thyroid Cancer, Papillary
Diagnostic value of fine needle aspiration BRAF(V600E) mutation analysis in papillary thyroid cancer: a systematic review and meta-analysis.
Thyroid Cancer, Papillary
Estrogen receptor subtype expression and regulation is altered in papillary thyroid cancer after menopause.
Thyroid Cancer, Papillary
Expression characteristics of proteins of IGF-1R, p-Akt, and survivin in papillary thyroid carcinoma patients with type 2 diabetes mellitus.
Thyroid Cancer, Papillary
Identification of Potential BRAF Inhibitor Joint Therapy Targets in PTC based on WGCAN and DCGA.
Thyroid Cancer, Papillary
Identification of unique heterozygous germline mutation, STK11 (p.F354L), in a child with encapsulated follicular variant of papillary thyroid carcinoma within 6 months of completing treatment for neuroblastoma.
Thyroid Cancer, Papillary
Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Immunohistochemistry is highly sensitive and specific for detecting the BRAF V600E mutation in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Key candidate genes associated with BRAFV600E in papillary thyroid carcinoma on microarray analysis.
Thyroid Cancer, Papillary
Lack of Association of B-type Raf Kinase V600E Mutation with High-risk Tumor Features and Adverse Outcome in Conventional and Follicular Variants of Papillary Thyroid Carcinoma.
Thyroid Cancer, Papillary
Long non-coding RNA DLEUI promotes papillary thyroid carcinoma progression by sponging miR-421 and increasing ROCK1 expression.
Thyroid Cancer, Papillary
Loss of Raf-1 kinase inhibitor protein expression is associated with lymph node metastasis in papillary thyroid cancer.
Thyroid Cancer, Papillary
Methylation status of genes in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
MicroRNA-26a suppresses the malignant biological behaviors of papillary thyroid carcinoma by targeting ROCK1 and regulating PI3K/AKT signaling pathway.
Thyroid Cancer, Papillary
MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies.
Thyroid Cancer, Papillary
MicroRNA-361-5p inhibits papillary thyroid carcinoma progression by targeting ROCK1.
Thyroid Cancer, Papillary
Morphoproteomics demonstrates activation of mammalian target of rapamycin pathway in papillary thyroid carcinomas with nuclear translocation of MTOR in aggressive histological variants.
Thyroid Cancer, Papillary
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Thyroid Cancer, Papillary
P21-activated kinase 4 involves TSH induced papillary thyroid cancer cell proliferation.
Thyroid Cancer, Papillary
PD-L1, PDK-1 and p-Akt are correlated in patients with papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Radiomics Study of Thyroid Ultrasound for Predicting BRAF Mutation in Papillary Thyroid Carcinoma: Preliminary Results.
Thyroid Cancer, Papillary
Relationships of FOXE1 and ATM genetic polymorphisms with papillary thyroid carcinoma risk: a meta-analysis.
Thyroid Cancer, Papillary
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Thyroid Cancer, Papillary
Silencing of long noncoding RNA H19 inhibited invasion and migration of papillary thyroid cancer cells via microRNA-138-dependent regulating of LRRK2.
Thyroid Cancer, Papillary
Silencing of long noncoding RNA RP11-476D10.1 enhances apoptosis and autophagy while inhibiting proliferation of papillary thyroid carcinoma cells via microRNA-138-5p-dependent inhibition of LRRK2.
Thyroid Cancer, Papillary
Single nucleotide polymorphisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Snail-1 Overexpression Correlates with Metastatic Phenotype in BRAFV600E Positive Papillary Thyroid Carcinoma.
Thyroid Cancer, Papillary
THE RELATIONSHIP OF BRAF
Thyroid Cancer, Papillary
Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2.
Thyroid Carcinoma, Anaplastic
Adaptor protein LNK promotes anaplastic thyroid carcinoma cell growth via 14-3-3 ?/? binding.
Thyroid Carcinoma, Anaplastic
Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
Thyroid Diseases
Shedding light on thyroid hormone disorders and Parkinson disease pathology: mechanisms and risk factors.
Thyroid Neoplasms
14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.
Thyroid Neoplasms
A systematic review of genetic studies of thyroid disorders in Taiwan.
Thyroid Neoplasms
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer.
Thyroid Neoplasms
BRAF Mutation in Papillary Thyroid Cancer and Its Value in Tailoring Initial Treatment: A Systematic Review and Meta-Analysis.
Thyroid Neoplasms
BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications.
Thyroid Neoplasms
BRAF mutation in thyroid cancer.
Thyroid Neoplasms
c-Myc is a major determinant for antitumor activity of Aurora A kinase inhibitor MLN8237 in thyroid cancer.
Thyroid Neoplasms
Calcium/Calmodulin-Dependent Protein Kinase II and Its Endogenous Inhibitor ? in Medullary Thyroid Cancer.
Thyroid Neoplasms
Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells.
Thyroid Neoplasms
Downregulated LRRK2 gene expression inhibits proliferation and migration while promoting the apoptosis of thyroid cancer cells by inhibiting activation of the JNK signaling pathway.
Thyroid Neoplasms
Exogenous Hydrogen Sulfide Regulates the Growth of Human Thyroid Carcinoma Cells.
Thyroid Neoplasms
Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines.
Thyroid Neoplasms
Identification of unique heterozygous germline mutation, STK11 (p.F354L), in a child with encapsulated follicular variant of papillary thyroid carcinoma within 6 months of completing treatment for neuroblastoma.
Thyroid Neoplasms
In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer.
Thyroid Neoplasms
Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells.
Thyroid Neoplasms
Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo.
Thyroid Neoplasms
Iodine promotes thyroid cancer development via SPANXA1 through the PI3K/AKT signalling pathway.
Thyroid Neoplasms
Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1.
Thyroid Neoplasms
miR-584 Suppresses Invasion and Cell Migration of Thyroid Carcinoma by Regulating the Target Oncogene ROCK1.
Thyroid Neoplasms
Multiple signaling pathways converge on beta-catenin in thyroid cancer.
Thyroid Neoplasms
Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.
Thyroid Neoplasms
Nanolock-Nanopore Facilitated Digital Diagnostics of Cancer Driver Mutation in Tumor Tissue.
Thyroid Neoplasms
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Thyroid Neoplasms
Papillary thyroid carcinoma in a 9-year-old girl with ataxia-telangiectasia.
Thyroid Neoplasms
PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma.
Thyroid Neoplasms
Peptide P11 suppresses the growth of human thyroid carcinoma by inhibiting the PI3K/AKT/mTOR signaling pathway.
Thyroid Neoplasms
Phase II trial of sorafenib in advanced thyroid cancer.
Thyroid Neoplasms
Phosphoproteomics of MAPK inhibition in BRAF-mutated cells and a role for the lethal synergism of dual BRAF and CK2 inhibition.
Thyroid Neoplasms
Post-transcriptional silencing of RET occurs, but is not required, during raf-1 mediated differentiation of medullary thyroid carcinoma cells.
Thyroid Neoplasms
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
Thyroid Neoplasms
RAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer.
Thyroid Neoplasms
Raf-1 Kinase Inhibitory Protein Expression in Thyroid Carcinomas.
Thyroid Neoplasms
RAF-1 promotes survival of thyroid cancer cells harboring RET/PTC1 rearrangement independently of ERK activation.
Thyroid Neoplasms
Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target.
Thyroid Neoplasms
Rapid and simple detection of hot spot point mutations of epidermal growth factor receptor, BRAF, and NRAS in cancers using the loop-hybrid mobility shift assay.
Thyroid Neoplasms
Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.
Thyroid Neoplasms
Relationship between thyroid tumor radiosensitivity and nuclear localization of DNA-dependent protein kinase catalytic subunit.
Thyroid Neoplasms
Risk Stratification Using a Novel Genetic Classifier Including PLEKHS1 Promoter Mutations for Differentiated Thyroid Cancer with Distant Metastasis.
Thyroid Neoplasms
Role and relevance of BRAF mutations in risk stratifying patients of papillary thyroid cancers along with a review of literature.
Thyroid Neoplasms
Silencing of A-Kinase Anchor Protein 4 (AKAP4) Inhibits Proliferation and Progression of Thyroid Cancer.
Thyroid Neoplasms
Snail-1 Overexpression Correlates with Metastatic Phenotype in BRAFV600E Positive Papillary Thyroid Carcinoma.
Thyroid Neoplasms
Sorafenib for the treatment of thyroid cancer: an updated review.
Thyroid Neoplasms
STK11 Mutation Identified in Thyroid Carcinoma.
Thyroid Neoplasms
Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta.
Thyroid Neoplasms
The detection of SAS1B in serum provides clues for early diagnosis of thyroid cancer.
Thyroid Neoplasms
The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.
Thyroid Neoplasms
The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition.
Thyroid Neoplasms
The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas.
Thyroid Neoplasms
THE RELATIONSHIP OF BRAF
Thyroid Neoplasms
Tumor suppressor role of notch1 and raf-1 signaling in medullary thyroid cancer cells.
Thyroid Neoplasms
[Construction of GSK-3beta-targeting RNAi adenovirus vector and the influence of Wnt/beta-catenin pathway in proliferation of human thyrocytes]
Thyroid Neoplasms
[Effects of serine/threonine-protein kinase B-Raf-activated long-chain non-coding RNA on apoptosis and autophagy in thyroid carcinoma cells].
Thyroid Nodule
Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.
Thyroid Nodule
Preoperative BRAF(V600E) mutation screening is unlikely to alter initial surgical treatment of patients with indeterminate thyroid nodules: A prospective case series of 960 patients.
Thyroiditis
Indicators of multifocality in papillary thyroid carcinoma concurrent with Hashimoto's thyroiditis.
Tics
Analysis of Chromatin Opening in Heterochromatic Non-Small Cell Lung Cancer Tumor-Initiating Cells in Relation to DNA-Damaging Antitumor Treatment.
Tics
Ovarian stanniocalcin is structurally unique in mammals and its production and release are regulated through the luteinizing hormone receptor.
Tics
Wnt/?-catenin activation and macrophage induction during liver cancer development following steatosis.
Tongue Neoplasms
Akt activation correlates with adverse outcome in tongue cancer.
Tooth Loss
Tooth Loss Induces Memory Impairment and Gliosis in App Knock-In Mouse Models of Alzheimer's Disease.
Torsades de Pointes
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Torsades de Pointes
Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits.
Toxoplasmosis
1NM-PP1 Treatment of Mice Infected with Toxoplasma gondii.
Toxoplasmosis
A Novel Calcium-Dependent Protein Kinase 1 Inhibitor Potently Prevents Toxoplasma gondii Transmission to Foetuses in Mouse.
Toxoplasmosis
A novel Toxoplasma gondii calcium-dependent protein kinase.
Toxoplasmosis
Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.
Toxoplasmosis
Characterization of an excreted/secreted antigen form of 14-3-3 protein in Toxoplasma gondii tachyzoites.
Toxoplasmosis
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
Toxoplasmosis
Evaluation of protective immune responses induced by DNA vaccines encoding Toxoplasma gondii surface antigen 1 (SAG1) and 14-3-3 protein in BALB/c mice.
Toxoplasmosis
Evaluation of protective immunity induced by recombinant calcium-dependent protein kinase 1 (TgCDPK1) protein against acute toxoplasmosis in mice.
Toxoplasmosis
Imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1 decrease the parasite burden in mice with acute toxoplasmosis.
Toxoplasmosis
Perspective on current and emerging drugs in the treatment of acute and chronic toxoplasmosis.
Toxoplasmosis
Protective efficacy of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice.
Toxoplasmosis
Targeted disruption of CK1? in Toxoplasma gondii increases acute virulence in mice.
Toxoplasmosis
Vaccination with recombinant Toxoplasma gondii CDPK3 induces protective immunity against experimental toxoplasmosis.
Toxoplasmosis, Congenital
Live Attenuated Pru:?cdpk2 Strain of Toxoplasma gondii Protects Against Acute, Chronic, and Congenital Toxoplasmosis.
transaldolase deficiency
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Trauma, Nervous System
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.
Trauma, Nervous System
Down-regulation of ROCK2 alleviates ethanol-induced cerebral nerve injury partly by the suppression of the NF-?B signaling pathway.
Tremor
A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson disease.
Tremor
Deficiency of the RI? subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.
Tremor
Diagnostic delay in Parkinson's disease caused by PRKN mutations.
Tremor
Identification of Three Novel LRRK2 Mutations associated with Parkinson's Disease in a Calabrian Population.
Tremor
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Tremor
LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study.
Tremor
Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease.
Tremor
Neuronal Apoptosis and Motor Deficits in Mice with Genetic Inhibition of GSK-3 Are Fas-Dependent.
Tremor
Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease.
Tremor
Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant.
Tremor
The discovery of LRRK2 p.R1441S, a novel mutation for Parkinson's disease, adds to the complexity of a mutational hotspot.
Tremor
Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screening.
Triple Negative Breast Neoplasms
A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.
Triple Negative Breast Neoplasms
A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer.
Triple Negative Breast Neoplasms
A Phase II Single Arm Pilot Study of the CHK1 Inhibitor Prexasertib (LY2606368) in BRCA Wild-Type, Advanced Triple-Negative Breast Cancer.
Triple Negative Breast Neoplasms
Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy.
Triple Negative Breast Neoplasms
AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer.
Triple Negative Breast Neoplasms
An In Vivo Study for Targeted Delivery of Curcumin in Human Triple Negative Breast Carcinoma Cells Using Biocompatible PLGA Microspheres Conjugated with Folic Acid.
Triple Negative Breast Neoplasms
Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases.
Triple Negative Breast Neoplasms
ATM kinase regulates tumor immunoreactions in lymphocyte-predominant breast cancer through modulation of NKG2D ligand and TNF cytokines on tumor cells.
Triple Negative Breast Neoplasms
Aurora A kinase activates YAP signaling in triple-negative breast cancer.
Triple Negative Breast Neoplasms
c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun.
Triple Negative Breast Neoplasms
Checkpoint Kinase 1 (CHK1) Inhibition Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Proton Irradiation via Rad51 Downregulation.
Triple Negative Breast Neoplasms
Chk1 as a new therapeutic target in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Discovery of a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer.
Triple Negative Breast Neoplasms
Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation.
Triple Negative Breast Neoplasms
Epigenetic changes and nuclear factor-?B activation, but not microRNA-224, downregulate Raf-1 kinase inhibitor protein in triple-negative breast cancer SUM 159 cells.
Triple Negative Breast Neoplasms
HMGA1 Modulates Gene Transcription Sustaining a Tumor Signalling Pathway Acting on the Epigenetic Status of Triple-Negative Breast Cancer Cells.
Triple Negative Breast Neoplasms
Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer.
Triple Negative Breast Neoplasms
Investigation of molecular alterations of AKT-3 in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Knockdown of A-kinase anchor protein 4 inhibits proliferation of triple-negative breast cancer cells in vitro and in vivo.
Triple Negative Breast Neoplasms
Knockdown of CSNK2ß suppresses MDA-MB231 cell growth, induces apoptosis, inhibits migration and invasion.
Triple Negative Breast Neoplasms
miR-143-3p targeting LIM domain kinase 1 suppresses the progression of triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
One therapeutic approach for triple-negative breast cancer: Checkpoint kinase 1 inhibitor AZD7762 combination with neoadjuvant carboplatin.
Triple Negative Breast Neoplasms
Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors.
Triple Negative Breast Neoplasms
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.
Triple Negative Breast Neoplasms
PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim.
Triple Negative Breast Neoplasms
Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways.
Triple Negative Breast Neoplasms
ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.
Triple Negative Breast Neoplasms
Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells.
Triple Negative Breast Neoplasms
Synergistic Interactions of 5-Fluorouracil with Inhibitors of Protein Kinase CK2 Correlate with p38 MAPK Activation and FAK Inhibition in the Triple-Negative Breast Cancer Cell Line.
Triple Negative Breast Neoplasms
Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.
Triple Negative Breast Neoplasms
The effects of RKIP gene expression on the biological characteristics of human triple-negative breast cancer cells in vitro.
Triple Negative Breast Neoplasms
[18F]F-ET-OTSSP167 Targets Maternal Embryo Leucine Zipper Kinase for PET Imaging of Triple-Negative Breast Cancer.
Trophoblastic Neoplasms
Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma.
Trophoblastic Tumor, Placental Site
Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma.
Trypanosomiasis, African
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.
Trypanosomiasis, African
The design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis.
Tuberculosis
A Comprehensive Study of the Interaction between Peptidoglycan Fragments and the Extracellular Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB.
Tuberculosis
A conserved dimer and global conformational changes in the structure of apo-PknE Ser/Thr protein kinase from Mycobacterium tuberculosis.
Tuberculosis
A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity.
Tuberculosis
A protein kinase inhibitor as an antimycobacterial agent.
Tuberculosis
A Serine/threonine kinase PknL, is involved in the adaptive response of Mycobacterium tuberculosis.
Tuberculosis
A serine/threonine protein kinase from Mycobacterium tuberculosis.
Tuberculosis
AKT1 polymorphisms are associated with tuberculosis in the Chinese population.
Tuberculosis
Allosteric activation by dimerization of the PknD receptor Ser/Thr protein kinase from Mycobacterium tuberculosis.
Tuberculosis
Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB.
Tuberculosis
An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice.
Tuberculosis
An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Tuberculosis
Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants.
Tuberculosis
Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase.
Tuberculosis
Biochemical and Spatial Coincidence in the Provisional Ser/Thr Protein Kinase Interaction Network of Mycobacterium tuberculosis.
Tuberculosis
Bioinformatics approach to prioritize known drugs towards repurposing for tuberculosis.
Tuberculosis
Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.
Tuberculosis
Chemical shift assignment of the intrinsically disordered N-terminus and the rubredoxin domain in the folded metal bound and unfolded oxidized state of mycobacterial protein kinase G.
Tuberculosis
Cloning, overexpression, and characterization of a serine/threonine protein kinase pknI from Mycobacterium tuberculosis H37Rv.
Tuberculosis
Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis.
Tuberculosis
Critical role of toll-like receptor 9 in morphine and Mycobacterium tuberculosis-Induced apoptosis in mice.
Tuberculosis
Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis.
Tuberculosis
Deletion of serine/threonine-protein kinase pknL from Mycobacterium tuberculosis reduces the efficacy of isoniazid and ethambutol.
Tuberculosis
Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice.
Tuberculosis
Development and validation of a sensitive LC-MS/MS method for the quantitation of IMB-YH-4py5-2H, an antituberculosis candidate, and its application to the pharmacokinetic study.
Tuberculosis
Development of a new generation of vectors for gene expression, gene replacement, and protein-protein interaction studies in mycobacteria.
Tuberculosis
Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis.
Tuberculosis
Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.
Tuberculosis
Evidence that a eukaryotic-type serine/threonine protein kinase from Mycobacterium tuberculosis regulates morphological changes associated with cell division.
Tuberculosis
Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase PknB.
Tuberculosis
FHA domain containing protein Rv0019c and Polyketide-associated protein PapA5, from substrates of Serine/Threonine Protein Kinase PknB to interacting proteins of Mycobacterium tuberculosis.
Tuberculosis
Forkhead-associated (FHA) Domain Containing ABC Transporter Rv1747 Is Positively Regulated by Ser/Thr Phosphorylation in Mycobacterium tuberculosis.
Tuberculosis
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ.
Tuberculosis
Global Profiling of PknG Interactions Using a Human Proteome Microarray Reveals Novel Connections with CypA.
Tuberculosis
GTPase activity of mycobacterial FtsZ is impaired due to its transphosphorylation by the eukaryotic-type Ser/Thr kinase, PknA.
Tuberculosis
HupB, a nucleoid-associated protein of Mycobacterium tuberculosis, is modified by serine/threonine protein kinases in vivo.
Tuberculosis
Identification of Novel Mycobacterial Inhibitors Against Mycobacterial Protein Kinase G.
Tuberculosis
In silico and experimental validation of protein-protein interactions between PknI and Rv2159c from Mycobacterium tuberculosis.
Tuberculosis
Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe-S center.
Tuberculosis
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
Tuberculosis
Insight into the structural requirements of aminopyrimidine derivatives for good potency against both purified enzyme and whole cells of M. tuberculosis: combination of HQSAR, CoMSIA, and MD simulation studies.
Tuberculosis
Interactome analysis and design of inhibitors against selected protein targets of Ser/Thr protein kinase (STPK) signaling pathways in Mycobacterium tuberculosis H37Rv.
Tuberculosis
Interdomain Interaction Reconstitutes the Functionality of PknA, a Eukaryotic Type Ser/Thr Kinase from Mycobacterium tuberculosis.
Tuberculosis
Key Structures and Interactions for Binding of Mycobacterium tuberculosis Protein Kinase B Inhibitors from Molecular Dynamics Simulation.
Tuberculosis
Lauric acid and myristic acid from Allium sativum inhibit the growth of Mycobacterium tuberculosis H37Ra: in silico analysis reveals possible binding to protein kinase B.
Tuberculosis
LRRK2 at the Interface Between Peripheral and Central Immune Function in Parkinson's.
Tuberculosis
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
Tuberculosis
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.
Tuberculosis
M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival.
Tuberculosis
M. tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog.
Tuberculosis
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.
Tuberculosis
Mycobacterial immunomodulation and viral manipulation of neuronal copper efflux in the setting of sporadic Parkinson's disease: A multi - hit, outside - in hypothesis of its pathogenesis.
Tuberculosis
Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b.
Tuberculosis
Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation.
Tuberculosis
Mycobacterium tuberculosis phagosomes exhibit altered calmodulin-dependent signal transduction: contribution to inhibition of phagosome-lysosome fusion and intracellular survival in human macrophages.
Tuberculosis
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity.
Tuberculosis
Mycobacterium tuberculosis Raf kinase inhibitor protein (RKIP) Rv2140c is involved in cell wall arabinogalactan biosynthesis via phosphorylation.
Tuberculosis
Mycobacterium tuberculosis RKIP (Rv2140c) dephosphorylates ERK/NF-?B upstream signaling molecules to subvert macrophage innate immune response.
Tuberculosis
Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch.
Tuberculosis
Mycobacterium tuberculosis Thymidylyltransferase RmlA Is Negatively Regulated by Ser/Thr Protein Kinase PknB.
Tuberculosis
Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD.
Tuberculosis
New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.
Tuberculosis
Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase.
Tuberculosis
NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G.
Tuberculosis
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase.
Tuberculosis
Phosphorylation of pyruvate kinase A by protein kinase J leads to the altered growth and differential rate of intracellular survival of mycobacteria.
Tuberculosis
Phosphorylation-dependent interaction between a serine/threonine kinase PknA and a putative cell division protein Wag31 in Mycobacterium tuberculosis.
Tuberculosis
PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis.
Tuberculosis
PknB remains an essential and a conserved target for drug development in susceptible and MDR strains of M. Tuberculosis.
Tuberculosis
pknE, a serine/threonine kinase of Mycobacterium tuberculosis modulates multiple apoptotic paradigms.
Tuberculosis
PknE, a serine/threonine protein kinase from Mycobacterium tuberculosis has a role in adaptive responses.
Tuberculosis
PknE, a serine/threonine protein kinase of Mycobacterium tuberculosis initiates survival crosstalk that also impacts HIV coinfection.
Tuberculosis
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
Tuberculosis
PknH, a transmembrane Hank's type serine/threonine kinase from Mycobacterium tuberculosis is differentially expressed under stress conditions.
Tuberculosis
PRECLINICAL PHARMACOKINETIC ANALYSIS OF (E)-METHYL-4-ARYL-4-OXABUT-2-ENOATE, A NOVEL SER/THR PROTEIN KINASE B INIBITOR, IN RATS.
Tuberculosis
Predictive Binding Affinity of Plant-Derived Natural Products Towards the Protein Kinase G Enzyme of Mycobacterium tuberculosis (MtPknG).
Tuberculosis
Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host.
Tuberculosis
Protein Kinase B (PknB) of Mycobacterium tuberculosis is essential for growth of the pathogen in vitro as well as for survival within the host.
Tuberculosis
Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112.
Tuberculosis
Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection.
Tuberculosis
Protein Kinase G confers survival advantage to Mycobacterium tuberculosis during latency like conditions.
Tuberculosis
Protein PknE, a novel transmembrane eukaryotic-like serine/threonine kinase from Mycobacterium tuberculosis.
Tuberculosis
Proteome and phosphoproteome analysis of the serine/threonine protein kinase E mutant of Mycobacterium tuberculosis.
Tuberculosis
Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response.
Tuberculosis
Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions.
Tuberculosis
Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis.
Tuberculosis
Retraction: PknE, a Serine/Threonine Protein Kinase of Mycobacterium tuberculosis Initiates Survival Crosstalk That Also Impacts HIV Coinfection.
Tuberculosis
RIPK2 polymorphisms and susceptibility to tuberculosis in a Western Chinese Han population.
Tuberculosis
Role of Mycobacterium tuberculosis Ser/Thr kinase PknF: implications in glucose transport and cell division.
Tuberculosis
Sclerotiorin inhibits protein kinase G from Mycobacterium tuberculosis and impairs mycobacterial growth in macrophages.
Tuberculosis
Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller.
Tuberculosis
Structural and genetic analyses of the Mycobacterium tuberculosis Protein Kinase B sensor domain identify a potential ligand binding site.
Tuberculosis
Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase.
Tuberculosis
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.
Tuberculosis
Targeting PknB, an eukaryotic-like serine/threonine protein kinase of Mycobacterium tuberculosis with phytomolecules.
Tuberculosis
The crystal structure of the catalytic domain of the Ser/Thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.
Tuberculosis
The Extracytoplasmic Domain of the Mycobacterium tuberculosis Ser/Thr Kinase PknB Binds Specific Muropeptides and Is Required for PknB Localization.
Tuberculosis
The Mycobacterium bovis homologous protein of the Mycobacterium tuberculosis serine/threonine protein kinase Mbk (PknD) is truncated.
Tuberculosis
The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo.
Tuberculosis
The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation.
Tuberculosis
The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c.
Tuberculosis
The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.
Tuberculosis
The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth.
Tuberculosis
The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division.
Tuberculosis
The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection.
Tuberculosis
Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination.
Tuberculosis
Tuning the Mycobacterium tuberculosis alternative sigma factor SigF through the multidomain regulator Rv1364c and osmosensory kinase, protein kinase D.
Tuberculosis
Two FHA domains on an ABC transporter, Rv1747, mediate its phosphorylation by PknF, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Tuberculosis
Understanding the role of PknJ in Mycobacterium tuberculosis: biochemical characterization and identification of novel substrate pyruvate kinase A.
Tuberculosis
Wag31, a homologue of the cell division protein DivIVA, regulates growth, morphology and polar cell wall synthesis in mycobacteria.
Tuberculosis, Pulmonary
[Overexpression of miR-125b promotes apoptosis of macrophages].
Tuberous Sclerosis
A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression.
Tuberous Sclerosis
Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated.
Tuberous Sclerosis
Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways.
Tuberous Sclerosis
BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.
Tuberous Sclerosis
cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.
Tuberous Sclerosis
Concomitant low-dose doxorubicin treatment and exercise.
Tuberous Sclerosis
Correction: The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Tuberous Sclerosis
Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells.
Tuberous Sclerosis
Downhill Running Excessive Training Inhibits Hypertrophy in Mice Skeletal Muscles with Different Fiber Type Composition.
Tuberous Sclerosis
Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium.
Tuberous Sclerosis
Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway.
Tuberous Sclerosis
Genetics and molecular biology of tuberous sclerosis complex.
Tuberous Sclerosis
Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process.
Tuberous Sclerosis
GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways.
Tuberous Sclerosis
Immunohistochemical Analysis of mTOR Pathway-Related Proteins in Kaposiform Hemangioendothelioma.
Tuberous Sclerosis
Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion.
Tuberous Sclerosis
Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs.
Tuberous Sclerosis
Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells.
Tuberous Sclerosis
Leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs.
Tuberous Sclerosis
MARCKSL1 exhibits anti-angiogenic effects through suppression of VEGFR-2-dependent Akt/PDK-1/mTOR phosphorylation.
Tuberous Sclerosis
MTOR Suppresses Environmental Particle-Induced Inflammatory Response in Macrophages.
Tuberous Sclerosis
NMDA receptor activation regulates sociability by its effect on mTOR signaling activity.
Tuberous Sclerosis
Novel Anti-Angiogenic and Anti-Tumour Activities of the N-Terminal Domain of NOEY2 via Binding to VEGFR-2 in Ovarian Cancer.
Tuberous Sclerosis
p38? senses environmental stress to control innate immune responses via mechanistic target of rapamycin.
Tuberous Sclerosis
PI3K/mTOR Signaling Pathways in Medulloblastoma.
Tuberous Sclerosis
RAD 001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia.
Tuberous Sclerosis
Regulation of tuberous sclerosis complex (TSC) function by 14-3-3 proteins.
Tuberous Sclerosis
Restraining PI3K: mTOR signalling goes back to the membrane.
Tuberous Sclerosis
Role of the PI3K/Akt, mTOR, and STK11/LKB1 pathways in the tumorigenesis of sclerosing hemangioma of the lung.
Tuberous Sclerosis
Sirolimus-induced signaling modifications in Kaposi's sarcoma with resolution in a liver transplant recipient.
Tuberous Sclerosis
Stimulation of muscle protein synthesis by prolonged parenteral infusion of leucine is dependent on amino acid availability in neonatal pigs.
Tuberous Sclerosis
Targeting phosphoinositide 3-kinase: moving towards therapy.
Tuberous Sclerosis
The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.
Tuberous Sclerosis
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Tuberous Sclerosis
The Putative Role of mTOR Inhibitors in Non-tuberous Sclerosis Complex-Related Epilepsy.
Tuberous Sclerosis
The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding.
Tuberous Sclerosis
Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.
Tuberous Sclerosis
Tuberous sclerosis genes regulate cellular 14-3-3 protein levels.
Tuberous Sclerosis
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
Tuberous Sclerosis
TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1.
Tuberous Sclerosis
[The effect of downregulation of MCT1 on the proliferation of glioma cells].
Tularemia
Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice.
type i protein arginine methyltransferase deficiency
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
Ureteral Obstruction
A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-?1/Smad3 Pathway.
Ureteral Obstruction
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
Ureteral Obstruction
PKB/SGK-Resistant GSK-3 Signaling Following Unilateral Ureteral Obstruction.
Ureteral Obstruction
Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice.
Ureteral Obstruction
Tubular HIPK2 is a key contributor to renal fibrosis.
Urinary Bladder Neck Obstruction
Mesenchymal stem cell therapy inhibited inflammatory and profibrotic pathways induced by partial bladder outlet obstruction and prevented high-pressure urine storage.
Urinary Bladder Neoplasms
19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage.
Urinary Bladder Neoplasms
4-HPR impairs bladder cancer cell migration and invasion by interfering with the Wnt5a/JNK and Wnt5a/MMP-2 signaling pathways.
Urinary Bladder Neoplasms
9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer.
Urinary Bladder Neoplasms
?-elemene induced anticancer effect in bladder cancer through upregulation of PTEN and suppression of AKT phosphorylation.
Urinary Bladder Neoplasms
A Novel Cyclic Pentadepsipeptide, N-Methylsansalvamide, Suppresses Angiogenic Responses and Exhibits Antitumor Efficacy against Bladder Cancer.
Urinary Bladder Neoplasms
Akt activation correlates with the tumor aggressiveness in Tunisian patients with bladder cancer.
Urinary Bladder Neoplasms
AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells.
Urinary Bladder Neoplasms
ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2?-Mediated Glycolysis.
Urinary Bladder Neoplasms
AMPKalpha2 Regulates Bladder Cancer Growth Through SKP2-mediated Degradation of p27.
Urinary Bladder Neoplasms
Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer.
Urinary Bladder Neoplasms
ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment.
Urinary Bladder Neoplasms
Aurora A Kinase as a diagnostic urinary marker for urothelial bladder cancer.
Urinary Bladder Neoplasms
Aurora kinase B is an independent protective factor in superficial bladder tumours with a dysfunctional G1 checkpoint.
Urinary Bladder Neoplasms
Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells.
Urinary Bladder Neoplasms
Benzyl isothiocyanate promotes miR-99a expression through ERK/AP-1-dependent pathway in bladder cancer cells.
Urinary Bladder Neoplasms
Beta-catenin mutations correlate with over expression of C-myc and cyclin D1 Genes in bladder cancer.
Urinary Bladder Neoplasms
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Urinary Bladder Neoplasms
CK1? as a potential therapeutic target to treat bladder cancer.
Urinary Bladder Neoplasms
Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells.
Urinary Bladder Neoplasms
Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2? contributes to human bladder cancer cell survival.
Urinary Bladder Neoplasms
DCAMKL1 is associated with the malignant status and poor outcome in bladder cancer.
Urinary Bladder Neoplasms
Down-regulation of CIT can inhibit the growth of human bladder cancer cells.
Urinary Bladder Neoplasms
Downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1.
Urinary Bladder Neoplasms
Downregulation of homeodomain-interacting protein kinase-2 contributes to bladder cancer metastasis by regulating Wnt signaling.
Urinary Bladder Neoplasms
Expression and Functions of Formyl Peptide Receptor 1 in Drug-Resistant Bladder Cancer.
Urinary Bladder Neoplasms
Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms.
Urinary Bladder Neoplasms
Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition.
Urinary Bladder Neoplasms
Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-?B/IKK pathway-induced apoptosis.
Urinary Bladder Neoplasms
Glycogen Synthase Kinase-3{beta}: A Prognostic Marker and a Potential Therapeutic Target in Human Bladder Cancer.
Urinary Bladder Neoplasms
Hypermethylation-mediated partial transcriptional silencing of DAP-kinase gene in bladder cancer.
Urinary Bladder Neoplasms
Inhibition of checkpoint kinase 1 potentiates anticancer activity of gemcitabine in bladder cancer cells.
Urinary Bladder Neoplasms
Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer.
Urinary Bladder Neoplasms
Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer.
Urinary Bladder Neoplasms
Knockdown of KNTC1 Inhibits the Proliferation, Migration and Tumorigenesis of Human Bladder Cancer Cells and Induces Apoptosis.
Urinary Bladder Neoplasms
Knockdown of TRIM26 inhibits the proliferation, migration and invasion of bladder cancer cells through the Akt/GSK3?/?-catenin pathway.
Urinary Bladder Neoplasms
LINC01638 lncRNA mediates the postoperative distant recurrence of bladder cancer by upregulating ROCK2.
Urinary Bladder Neoplasms
Lnc-MUC20-9 binds to ROCK1 and functions as a tumor suppressor in bladder cancer.
Urinary Bladder Neoplasms
Matrine inhibits bladder cancer cell growth and invasion in vitro through PI3K/AKT signaling pathway: An experimental study.
Urinary Bladder Neoplasms
MicroRNA-124-3p affects proliferation, migration and apoptosis of bladder cancer cells through targeting AURKA.
Urinary Bladder Neoplasms
MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1.
Urinary Bladder Neoplasms
MicroRNA-1280 inhibits invasion and metastasis by targeting ROCK1 in bladder cancer.
Urinary Bladder Neoplasms
MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1.
Urinary Bladder Neoplasms
MiR-122 targets VEGFC in bladder cancer to inhibit tumor growth and angiogenesis.
Urinary Bladder Neoplasms
Overexpression of Citron Rho-Interacting Serine/Threonine Kinase Associated with Poor Outcome in Bladder Cancer.
Urinary Bladder Neoplasms
Overexpression of ROCK1 promotes cancer cell proliferation and is associated with poor prognosis in human urothelial bladder cancer.
Urinary Bladder Neoplasms
Phospholipase C-? regulates bladder cancer cells via ATM/EXO1.
Urinary Bladder Neoplasms
PI3K/AKT pathway genetic alterations and dysregulation of expression in bladder cancer.
Urinary Bladder Neoplasms
Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M.
Urinary Bladder Neoplasms
Rapamycin enhances growth inhibition on urothelial carcinoma cells through LKB1 deficiency-mediated mitochondrial dysregulation.
Urinary Bladder Neoplasms
Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression.
Urinary Bladder Neoplasms
Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase.
Urinary Bladder Neoplasms
Targeting protein kinase CK2 suppresses bladder cancer cell survival via the glucose metabolic pathway.
Urinary Bladder Neoplasms
The association of death-associated protein kinase hypermethylation with early recurrence in superficial bladder cancers.
Urinary Bladder Neoplasms
The Investigational Aurora Kinase A Inhibitor MLN8237 Induces Defects in Cell Viability and Cell-Cycle Progression in Malignant Bladder Cancer Cells In Vitro and In Vivo.
Urinary Bladder Neoplasms
The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates.
Urinary Bladder Neoplasms
Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells.
Urinary Bladder, Neurogenic
Electroacupuncture improves neurogenic bladder dysfunction through activation of NGF/TrkA signaling in a rat model.
Urinary Bladder, Overactive
Gene expression in urinary incontinence and pelvic organ prolapse: a review of literature.
Urinary Incontinence
Gene expression in urinary incontinence and pelvic organ prolapse: a review of literature.
Urinary Retention
A mechanistic study on urine retention in d-amphetamine addicts.
Urogenital Neoplasms
Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines.
Urogenital Neoplasms
MIF family proteins in genitourinary cancer: tumorigenic roles and therapeutic potential.
Uterine Cervical Neoplasms
?-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling.
Uterine Cervical Neoplasms
?2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway.
Uterine Cervical Neoplasms
Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2?.
Uterine Cervical Neoplasms
Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer.
Uterine Cervical Neoplasms
Cell-type-specific Modulation of Non-homologous End Joining of Gamma Ray-induced DNA Double-strand Breaks by cAMP Signaling in Human Cancer Cells.
Uterine Cervical Neoplasms
Correlation between homeodomain-interacting protein kinase 2 and apoptosis in cervical cancer.
Uterine Cervical Neoplasms
Cytotoxic activity of 3,6-dihydroxyflavone in human cervical cancer cells and its therapeutic effect on c-Jun N-terminal kinase inhibition.
Uterine Cervical Neoplasms
DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis.
Uterine Cervical Neoplasms
Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents.
Uterine Cervical Neoplasms
Destablilization of TRAF6 by DRAK1 Suppresses Tumor Growth and Metastasis in Cervical Cancer Cells.
Uterine Cervical Neoplasms
Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237.
Uterine Cervical Neoplasms
Differential impact of Raf-1 kinase activity on tumor cell resistance to paclitaxel and docetaxel.
Uterine Cervical Neoplasms
Differential proteins among normal cervix cells and cervical cancer cells with HPV-16 infection, through mass spectrometry-based Proteomics (2D-DIGE) in women from Southern México.
Uterine Cervical Neoplasms
Discovery of cyclin-dependent kinase inhibitor, CR229, using structurebased drug screening.
Uterine Cervical Neoplasms
E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer.
Uterine Cervical Neoplasms
Enhancement of Radiation Effectiveness in Cervical Cancer Cells by Combining Ionizing Radiation with Hyperthermia and Molecular Targeting Agents.
Uterine Cervical Neoplasms
Experimental study on the apoptosis of cervical cancer Hela cells induced by juglone through c-Jun N-terminal kinase/c-Jun pathway.
Uterine Cervical Neoplasms
Exploration of the molecular mechanisms of cervical cancer based on mRNA expression profiles and predicted microRNA interactions.
Uterine Cervical Neoplasms
Expression and Humoral Response of A-Kinase Anchor Protein 4 in Cervical Cancer.
Uterine Cervical Neoplasms
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Uterine Cervical Neoplasms
Expression of DNA damage response proteins and complete remission after radiotherapy of stage IB-IIA of cervical cancer.
Uterine Cervical Neoplasms
Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy.
Uterine Cervical Neoplasms
Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
Uterine Cervical Neoplasms
Gene silencing of A-kinase anchor protein 4 inhibits cervical cancer growth in vitro and in vivo.
Uterine Cervical Neoplasms
Genomic alterations in STK11 can predict clinical outcomes in cervical cancer patients.
Uterine Cervical Neoplasms
HOXA5 inhibits the proliferation and induces the apoptosis of cervical cancer cells via regulation of protein kinase B and p27.
Uterine Cervical Neoplasms
Human papillomavirus 16 E6 increases the radiosensitivity of p53-mutated cervical cancer cells, associated with up-regulation of aurora A.
Uterine Cervical Neoplasms
Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells.
Uterine Cervical Neoplasms
Immunohistochemical detection of Raf kinase inhibitor protein in normal cervical tissue and cervical cancer tissue.
Uterine Cervical Neoplasms
Immunohistochemical expression of 14-3-3 sigma protein in various histological subtypes of uterine cervical cancers.
Uterine Cervical Neoplasms
Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer.
Uterine Cervical Neoplasms
Inhibition of Aurora A and Aurora B Is Required for the Sensitivity of HPV-Driven Cervical Cancers to Aurora Kinase Inhibitors.
Uterine Cervical Neoplasms
Inhibition of Aurora A promotes chemosensitivity via inducing cell cycle arrest and apoptosis in cervical cancer cells.
Uterine Cervical Neoplasms
Interaction between 14-3-3? and PrP influences the dimerization of 14-3-3 and fibrillization of PrP106-126.
Uterine Cervical Neoplasms
Interplay of microRNAs to genetic, epigenetic, copy number variations of cervical cancer related genes.
Uterine Cervical Neoplasms
Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells.
Uterine Cervical Neoplasms
Latex of euphorbia antiquorum induces apoptosis in human cervical cancer cells via c-jun n-terminal kinase activation and reactive oxygen species production.
Uterine Cervical Neoplasms
LncRNA DANCR promotes cervical cancer progression by upregulating ROCK1 via sponging miR-335-5p.
Uterine Cervical Neoplasms
lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer.
Uterine Cervical Neoplasms
Long non-coding RNA cancer susceptibility candidate 2 inhibits the cell proliferation, invasion and angiogenesis of cervical cancer through the MAPK pathway.
Uterine Cervical Neoplasms
Long Noncoding RNA SNHG7, a Molecular Sponge for microRNA-485, Promotes the Aggressive Behavior of Cervical Cancer by Regulating PAK4.
Uterine Cervical Neoplasms
Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression.
Uterine Cervical Neoplasms
MicroRNA-18a enhances the radiosensitivity of cervical cancer cells by promoting radiation-induced apoptosis.
Uterine Cervical Neoplasms
MicroRNA-217 functions as a tumor suppressor in cervical cancer cells through targeting Rho-associated protein kinase 1.
Uterine Cervical Neoplasms
MicroRNA-99b suppresses human cervical cancer cell activity by inhibiting the PI3K/AKT/mTOR signaling pathway.
Uterine Cervical Neoplasms
MiR-1258 promotes the apoptosis of cervical cancer cells by regulating the E2F1/P53 signaling pathway.
Uterine Cervical Neoplasms
Osthole promotes the suppressive effects of cisplatin on NRF2 expression to prevent drug-resistant cervical cancer progression.
Uterine Cervical Neoplasms
Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy.
Uterine Cervical Neoplasms
Prognostic and predictive roles of microRNA?411 and its target STK17A in evaluating radiotherapy efficacy and their effects on cell migration and invasion via the p53 signaling pathway in cervical cancer.
Uterine Cervical Neoplasms
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
Uterine Cervical Neoplasms
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
Uterine Cervical Neoplasms
RKIP Inhibition in Cervical Cancer Is Associated with Higher Tumor Aggressive Behavior and Resistance to Cisplatin Therapy.
Uterine Cervical Neoplasms
SMAD3 inducing the transcription of ?STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.
Uterine Cervical Neoplasms
Study on the effect of Integrin ?V?6 on proliferation and apoptosis of cervical cancer cells.
Uterine Cervical Neoplasms
Synthesis, characterization, and anticancer activity of two mixed ligand copper(ii) complexes by regulating the VEGF/VEGFR2 signaling pathway.
Uterine Cervical Neoplasms
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/?-catenin signaling pathway in cervical cancer.
Uterine Cervical Neoplasms
The PI3KCA and AKT Inhibitory Activities of Litsea Cubeba Lour. Fruits and Heartwoods Towards Hela Cells.
Uterine Cervical Neoplasms
The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa.
Uterine Cervical Neoplasms
TRIP4 promotes tumor growth and metastasis and regulates radiosensitivity of cervical cancer by activating MAPK, PI3K/AKT, and hTERT signaling.
Uterine Cervical Neoplasms
Vorinostat upregulates MICA via the PI3K/Akt pathway to enhance the ability of natural killer cells to kill tumor cells.
Uterine Cervical Neoplasms
[Correlation of HIPK2 expression with HPV infection and apoptosis in cervical cancer]
Uterine Cervical Neoplasms
[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]
Uterine Neoplasms
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol.
Uterine Neoplasms
LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment.
Uveitis
A peptide inhibitor of c-Jun N-terminal kinase for the treatment of Endotoxin-Induced Uveitis.
Uveitis
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Uveitis
Subconjunctival injection of XG-102, a c-Jun N-terminal kinase inhibitor peptide, in the treatment of endotoxin-induced uveitis in rats.
Vaccinia
A mitogenic signal triggered at an early stage of vaccinia virus infection: implication of MEK/ERK and protein kinase A in virus multiplication.
Vaccinia
Aurora A controls CD8+ T cell cytotoxic activity and antiviral response.
Vaccinia
Casein kinase 2 regulates vaccinia virus actin tail formation.
Vaccinia
Characterization of vaccinia virus gene B12R.
Vaccinia
Emerging biological functions of the vaccinia-related kinase (VRK) family.
Vaccinia
Expression of constitutively active CaMKII in target tissue modifies presynaptic axon arbor growth.
Vaccinia
Expression of the insulin receptor with a recombinant vaccinia virus. Biochemical evidence that the insulin receptor has intrinsic serine kinase activity.
Vaccinia
Expression of the P-protein of the human hepatitis B virus in a vaccinia virus system and detection of the nucleocapsid-associated P-gene product by radiolabelling at newly introduced phosphorylation sites.
Vaccinia
Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal.
Vaccinia
Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R.
Vaccinia
Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase.
Vaccinia
IL12 p35 and p40 subunit genes administered as pPAL plasmid constructs do not improve protection of pPAL-LACK vaccine against canine leishmaniasis.
Vaccinia
Molecular cloning and characterization of a novel nuclear protein kinase in mice.
Vaccinia
Phosphorylation of ribosomal proteins by the vaccinia virus B1R protein kinase.
Vaccinia
Regulation of viral intermediate gene expression by the vaccinia virus B1 protein kinase.
Vaccinia
Role of cell signaling in poxvirus-mediated foreign gene expression in mammalian cells.
Vaccinia
Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase.
Vaccinia
The vaccinia virus B1R gene product is a serine/threonine protein kinase.
Vaccinia
The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication.
Vaccinia
The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus.
Vaccinia
Vaccinia protein kinase 2: a second essential serine/threonine protein kinase encoded by vaccinia virus.
Vaccinia
Vaccinia virus gene B1R encodes a 34-kDa serine/threonine protein kinase that localizes in cytoplasmic factories and is packaged into virions.
Vaccinia
Vaccinia virus morphogenesis is blocked by temperature-sensitive mutations in the F10 gene, which encodes protein kinase 2.
Varicocele
14-3-3 epsilon plays an important role in testicular germ cell apoptosis: A functional proteomic study of experimental varicocele.
Vascular Calcification
Aberrant activation of Wnt pathways in arteries associates with vascular calcification in chronic kidney disease.
Vascular Calcification
Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of ?-Klotho.
Vascular Calcification
Role of PKB/SGK-dependent phosphorylation of GSK-3?/? in vascular calcification during cholecalciferol overload in mice.
Vascular Diseases
Ca2/Calmodulin-Dependent Protein Kinase- II in Vasoactive Peptide-Induced Responses and Vascular Biology.
Vascular Diseases
CaMKII in the cardiovascular system: sensing redox states.
Vascular Diseases
Gene modification with integrin-linked kinase improves function of endothelial progenitor cells in pre-eclampsia in vitro.
Vascular Diseases
Glycogen synthase kinase-3 mediates endothelial cell activation by tumor necrosis factor-alpha.
Vascular Diseases
Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death.
Vascular Diseases
High glucose promotes vascular smooth muscle cell proliferation by upregulating proto-oncogene serine/threonine-protein kinase Pim-1 expression.
Vascular Diseases
Histopathological study of JNK in venous wall of patients with chronic venous insufficiency related to osteogenesis process.
Vascular Diseases
Inhibition of p90RSK is critical to abolish Angiotensin II-induced rat aortic smooth muscle cell proliferation and migration.
Vascular Diseases
Interactive Roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases.
Vascular Diseases
Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling.
Vascular System Injuries
Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway.
Vascular System Injuries
Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells.
Vascular System Injuries
Ca2+/calmodulin-dependent protein kinase II function in vascular remodelling.
Vascular System Injuries
miR-155-dependent regulation of mammalian sterile 20-like kinase 2 (MST2) coordinates inflammation, oxidative stress and proliferation in vascular smooth muscle cells.
Vascular System Injuries
NF1 regulates a Ras-dependent vascular smooth muscle proliferative injury response.
Vascular System Injuries
Regulation of the versican promoter by the beta-catenin-T-cell factor complex in vascular smooth muscle cells.
Vascular System Injuries
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
Vascular System Injuries
The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9.
Vascular System Injuries
The Multifunctional Ca2+/Calmodulin-dependent Kinase II {delta} (CaMKII{delta}) Controls Neointima Formation after Carotid Ligation and Vascular Smooth Muscle Cell Proliferation through Cell Cycle Regulation by p21.
Vascular System Injuries
Vein graft arterialization causes differential activation of mitogen-activated protein kinases.
Vasculitis
14-3-3 in Thoracic Aortic Aneurysms: Identification of a Novel Autoantigen in Large Vessel Vasculitis.
Vasculitis
Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.
Vasculitis
Correlation between serum cysteine-rich protein 61 and disease activity of antineutrophil cytoplasmic antibody-associated vasculitis.
Vasospasm, Intracranial
Inhibition of c-Jun N-terminal kinase pathway attenuates cerebral vasospasm after experimental subarachnoid hemorrhage through the suppression of apoptosis.
Vasospasm, Intracranial
Possible Role of Raf-1 Kinase in the Development of Cerebral Vasospasm and Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats.
Vasospasm, Intracranial
Role of c-Jun N-terminal kinase in cerebral vasospasm after experimental subarachnoid hemorrhage.
Venous Thrombosis
A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant.
Venous Thrombosis
Role and mechanism of tissue plasminogen activator in venous wall fibrosis remodeling after deep venous thrombosis via the glycogen synthase kinase-3 beta signaling pathway.
Ventilator-Induced Lung Injury
Death-associated Protein Kinase 1 Mediates Ventilator-induced Lung Injury in Mice by Promoting Alveolar Epithelial Cell Apoptosis.
Ventilator-Induced Lung Injury
Death-Associated Protein Kinase 1 Promotes Alveolar Epithelial Cell Apoptosis and Ventilator-Induced Lung Injury Through P53 Pathway.
Ventilator-Induced Lung Injury
Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury.
Ventricular Dysfunction, Left
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.
Ventricular Dysfunction, Left
Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.
Ventricular Dysfunction, Left
Inhibition of glycogen synthase kinase 3beta during heart failure is protective.
Ventricular Fibrillation
Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart.
Vesicular Stomatitis
A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response.
Vesicular Stomatitis
A regulatory role for cAMP-dependent protein kinase in protein traffic along the exocytic route.
Vesicular Stomatitis
Autophagy and innate immunity: Insights from invertebrate model organisms.
Vesicular Stomatitis
Casein kinase II is the P protein phosphorylating cellular kinase associated with the ribonucleoprotein complex of purified vesicular stomatitis virus.
Vesicular Stomatitis
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Vesicular Stomatitis
HIPK2 is necessary for type I interferon-mediated antiviral immunity.
Vesicular Stomatitis
Identification and characterization of serine/threonine protein kinase activity intrinsic to the L protein of vesicular stomatitis virus New Jersey.
Vesicular Stomatitis
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Vesicular Stomatitis
Multimerization and transcriptional activation of the phosphoprotein (P) of vesicular stomatitis virus by casein kinase-II.
Vesicular Stomatitis
Phosphorylated states of vesicular stomatitis virus P protein in vitro and in vivo.
Vesicular Stomatitis
Phosphorylation by cellular casein kinase II is essential for transcriptional activity of vesicular stomatitis virus phosphoprotein P.
Vesicular Stomatitis
Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II.
Vesicular Stomatitis
Phosphorylation of vesicular stomatitis virus M protein: evidence for a second virion-associated protein serine kinase activity.
Vesicular Stomatitis
Phosphorylation within the amino-terminal acidic domain I of the phosphoprotein of vesicular stomatitis virus is required for transcription but not for replication.
Vesicular Stomatitis
Role of cellular casein kinase II in the function of the phosphoprotein (P) subunit of RNA polymerase of vesicular stomatitis virus.
Vesicular Stomatitis
The transcriptional form of the phosphoprotein of vesicular stomatitis virus is a trimer: structure and stability.
Virus Diseases
14-3-3 is a VP3-binding protein involved in Macrobrachium rosenbergii Taihu virus infection in shrimp.
Virus Diseases
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Virus Diseases
A ?Raf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures.
Virus Diseases
A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient.
Virus Diseases
A mitogenic signal triggered at an early stage of vaccinia virus infection: implication of MEK/ERK and protein kinase A in virus multiplication.
Virus Diseases
Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8.
Virus Diseases
Adenosine Monophosphate-Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection.
Virus Diseases
Altered cholesterol trafficking in herpesvirus-infected arterial cells. Evidence for viral protein kinase-mediated cholesterol accumulation.
Virus Diseases
Antisense Oligonucleotides Targeting Raf-1 Block Japanese Encephalitis Virus In Vitro and In Vivo.
Virus Diseases
Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.
Virus Diseases
Aurora A controls CD8+ T cell cytotoxic activity and antiviral response.
Virus Diseases
BmAtg13 promotes the replication and proliferation of Bombyx mori nucleopolyhedrovirus.
Virus Diseases
Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection.
Virus Diseases
Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins.
Virus Diseases
Cytosolic RNA recognition pathway activates 14-3-3 protein mediated signaling and caspase-dependent disruption of cytokeratin network in human keratinocytes.
Virus Diseases
Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.
Virus Diseases
Dynamic flexibility of double-stranded RNA activated PKR in solution.
Virus Diseases
Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2.
Virus Diseases
Expression of Raf kinase inhibitor protein is downregulated in response to Newcastle disease virus infection to promote viral replication.
Virus Diseases
Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/?-Catenin Pathway.
Virus Diseases
GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response.
Virus Diseases
GSK-3-associated signaling is crucial to virus infection of cells.
Virus Diseases
Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis.
Virus Diseases
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.
Virus Diseases
Human gene profiling in response to the active protein kinase, interferon-induced serine/threonine protein kinase (PKR), in infected cells. Involvement of the transcription factor ATF-3 IN PKR-induced apoptosis.
Virus Diseases
Identification of a c-Jun homolog from Litopenaeus vannamei as a downstream substrate of JNK in response to WSSV infection.
Virus Diseases
Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection.
Virus Diseases
Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells.
Virus Diseases
Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity.
Virus Diseases
Insertions in the gG gene of pseudorabies virus reduce expression of the upstream Us3 protein and inhibit cell-to-cell spread of virus infection.
Virus Diseases
Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and Type I interferon signaling.
Virus Diseases
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.
Virus Diseases
Mitogen-activated protein kinase-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection.
Virus Diseases
mTOR inhibition and p53 activation, microRNAs: The possible therapy against pandemic COVID-19.
Virus Diseases
mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses.
Virus Diseases
Oncolysis of canine tumor cells by myxoma virus lacking the serp2 gene.
Virus Diseases
One-thousand-and-one substrates of protein kinase CK2?
Virus Diseases
Phosphoproteomics Combined with Quantitative 14-3-3-affinity Capture Identifies SIRT1 and RAI as Novel Regulators of Cytosolic Double-stranded RNA Recognition Pathway.
Virus Diseases
Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection.
Virus Diseases
Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.
Virus Diseases
Point mutations in BHV-1 Us3 gene abolish its ability to induce cytoskeletal changes in various cell types.
Virus Diseases
Progression of naive intraepithelial neoplasia genome to aggressive squamous cell carcinoma genome of uterine cervix.
Virus Diseases
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Virus Diseases
RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity.
Virus Diseases
Role of the p21-activated kinases (PAKs) in influenza A virus replication.
Virus Diseases
Roles of Stress-Activated Protein Kinases in the replication of Singapore grouper iridovirus and regulation of the inflammatory responses in grouper cells.
Virus Diseases
Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes.
Virus Diseases
Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
Virus Diseases
Small molecule inhibitors of the RNA-dependent protein kinase.
Virus Diseases
SnRK1 phosphorylation of AL2 delays Cabbage leaf curl virus infection in Arabidopsis.
Virus Diseases
Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.
Virus Diseases
Stress-activated protein kinases are involved in coxsackievirus B3 viral progeny release.
Virus Diseases
Structural tuning of the fluorescent protein iLOV for improved photostability.
Virus Diseases
Synthesis and biological evaluation of novel 2 (4`-hydroxynaphthyl) chromen-4-one as a CK2 inhibitor.
Virus Diseases
Targeting Casein kinase 2 with quercetin or enzymatically modified isoquercitrin as a strategy for boosting the type 1 interferon response to viruses and promoting cardiovascular health.
Virus Diseases
The Alphaherpesvirus Serine/Threonine Kinase Us3 Disrupts PML Nuclear Bodies.
Virus Diseases
The Dietary Restriction-Like Gene drl-1, Which Encodes a Putative Serine/Threonine Kinase, Is Essential for Orsay Virus Infection in Caenorhabditis elegans.
Virus Diseases
The down-regulation of casein kinase 1 alpha as a host defense response against infectious bursal disease virus infection.
Virus Diseases
The kinase CK1? controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.
Virus Diseases
The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells.
Virus Diseases
The Multifarious Role of 14-3-3 Family of Proteins in Viral Replication.
Virus Diseases
The phosphorylation profile of protein kinase A substrates is modulated during Varicella-zoster virus infection.
Virus Diseases
The role of 14-3-3 proteins in cell signalling pathways and virus infection.
Virus Diseases
The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation.
Virus Diseases
The Us3 protein kinase of herpes simplex virus 1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad.
Virus Diseases
Varicella-zoster virus infection of human fibroblast cells activates the c-Jun N-terminal kinase pathway.
Virus Diseases
VZV ORF47 Serine Protein Kinase and Its Viral Substrates.
Virus Diseases
[Mechanism of nuclear translocation of hypoxia-inducible factor-1? in influenza A (H1N1) virus infected-alveolar epithelial cells].
Visna
Involvement of a membrane-associated serine/threonine kinase complex in cellular binding of visna virus.
Vitiligo
?icroRNA?421 participates in vitiligo development through regulating human melanocyte survival by targeting receptor?interacting serine/threonine kinase 1.
Vitiligo
SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival.
Vitreoretinopathy, Proliferative
Phosphoinositide-3-kinase ? inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells.
Vitreoretinopathy, Proliferative
Protein Kinase A Inhibitor H89 Attenuates Experimental Proliferative Vitreoretinopathy.
von Hippel-Lindau Disease
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Vulvar Neoplasms
ROCK1 as a novel prognostic marker in vulvar cancer.
Waldenstrom Macroglobulinemia
A Multicenter Phase II Study of Single-Agent Enzastaurin in Previously Treated Waldenstrom Macroglobulinemia.
Warts
A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient.
Warts
Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells.
Warts
Drosophila casein kinase 2 (CK2) promotes warts protein to suppress Yorkie protein activity for growth control.
Warts
Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo.
Warts
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.
Warts
In vivo regulation of Yorkie phosphorylation and localization.
Warts
Lats2 is a negative regulator of myocyte size in the heart.
Warts
Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila.
Warts
Proteomic analysis of steroid-triggered autophagic programmed cell death during Drosophila development.
Warts
Roles of Membrane and Vesicular Traffic in Regulation of the Hippo Pathway.
Warts
The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.
Warts
The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie.
Warts
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.
Warts
Tumor suppressor LATS1 is a negative regulator of oncogene YAP.
Warts
Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function.
Warts
WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.
Warts
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor.
Werner Syndrome
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.
Werner Syndrome
Identification of proteins in the hamster DNA end-binding complex.
Werner Syndrome
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
West Nile Fever
Virus-induced Ca2+ influx extends survival of west nile virus-infected cells.
West Nile Fever
West nile virus-induced activation of mammalian target of rapamycin complex 1 supports viral growth and viral protein expression.
Whipple Disease
Isolated CNS Whipple disease with normal brain MRI and false-positive CSF 14-3-3 protein: a case report and review of the literature.
Whipple Disease
Laboratory diagnosis of central nervous system infections.
Whooping Cough
5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus.
Whooping Cough
?(2) -Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes.
Whooping Cough
?-Opioid receptors stimulate the metabolic sensor AMP-activated protein kinase through coincident signaling with G(q/11)-coupled receptors.
Whooping Cough
?-Tetrahydrocannabinol induces cytotoxicity in macrophage J774-1 cells: involvement of cannabinoid receptor 2 and p38 MAPK.
Whooping Cough
A new signalling pathway for parallel fibre presynaptic type 4 metabotropic glutamate receptors (mGluR4) in the rat cerebellar cortex.
Whooping Cough
A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes.
Whooping Cough
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger.
Whooping Cough
Acetylcholine elicits a rebound stimulation of Ca2+ current mediated by pertussis toxin-sensitive G protein and cAMP-dependent protein kinase A in atrial myocytes.
Whooping Cough
Activation of G proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons.
Whooping Cough
Activation of microtubule-associated protein kinase (Erk) and p70 S6 kinase by D2 dopamine receptors.
Whooping Cough
Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis.
Whooping Cough
Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent.
Whooping Cough
Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.
Whooping Cough
Activation of the {beta}-catenin/T-cell-specific transcription factor/lymphoid enhancer factor-1 pathway by plasminogen activators in ECV304 carcinoma cells.
Whooping Cough
Adenosine attenuates oxidant injury in human proximal tubular cells via A(1) and A(2a) adenosine receptors.
Whooping Cough
Adrenergic receptors inhibit TRPV1 activity in the dorsal root ganglion neurons of rats.
Whooping Cough
Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry.
Whooping Cough
Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Whooping Cough
Angiotensin II induces diverse signal transduction pathways via both Gq and Gi proteins in liver epithelial cells.
Whooping Cough
ATP-induced inhibition of Na+, K+, Cl- cotransport in Madin-Darby canine kidney cells: lack of involvement of known purinoceptor-coupled signaling pathways.
Whooping Cough
Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1.
Whooping Cough
Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subunits and the phosphoinositide 3-kinase pathway.
Whooping Cough
Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus.
Whooping Cough
Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts.
Whooping Cough
cAMP and protein kinase A modulate cholinergic rapid eye movement sleep generation.
Whooping Cough
Cannabinoid CB1 receptor-mediated inhibition of glutamate release from rat hippocampal synaptosomes.
Whooping Cough
Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling.
Whooping Cough
Collagen Synthesis Is Suppressed in Dermal Fibroblasts by the Human Antimicrobial Peptide LL-37.
Whooping Cough
Comprehensive Analysis of LncRNA-mRNA Expression Profiles and the ceRNA Network Associated with Pyroptosis in LPS-Induced Acute Lung Injury.
Whooping Cough
Contribution of cAMP to the inhibitory effect of non-steroidal anti-inflammatory drugs in rat uterine smooth muscle.
Whooping Cough
Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.
Whooping Cough
Coupling of serotonin 5-HT1B receptors to activation of mitogen-activated protein kinase (ERK-2) and p70 S6 kinase signaling systems.
Whooping Cough
Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages.
Whooping Cough
Cyclic phosphatidic acid elicits neurotrophin-like actions in embryonic hippocampal neurons.
Whooping Cough
Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts.
Whooping Cough
Dexmedetomidine Inhibits ASIC Activity via Activation of ?2A Adrenergic Receptors in Rat Dorsal Root Ganglion Neurons.
Whooping Cough
Direct activation of second messenger pathways mimics cell adhesion molecule-dependent neurite outgrowth.
Whooping Cough
Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal.
Whooping Cough
Dopamine stimulates 45Ca2+ uptake through cAMP, PLC/PKC, and MAPKs in renal proximal tubule cells.
Whooping Cough
Dual effects of ATP on the potassium channel and intracellular Ca2+ release in smooth muscle cells of the bovine brain arteries.
Whooping Cough
Effects of angiotensin II on the action potential durations of atrial myocytes in hypertensive rats.
Whooping Cough
Effects of parathyroid hormone on cytosolic calcium of rat adipocytes.
Whooping Cough
Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein.
Whooping Cough
Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells.
Whooping Cough
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
Whooping Cough
Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30.
Whooping Cough
Evidence for a cyclic AMP-dependent pathway in angiotensin AT1-receptor activation of human omental arteries.
Whooping Cough
Extracellular signal-regulated kinase 1/2 activation by myometrial oxytocin receptor involves Galpha(q)Gbetagamma and epidermal growth factor receptor tyrosine kinase activation.
Whooping Cough
Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein ?? subunit-dependent pathway in rat cerebrocortical nerve terminals.
Whooping Cough
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
Whooping Cough
G-proteins are involved in riluzole inhibition of high voltage-activated calcium channels in rat dorsal root ganglion neurons.
Whooping Cough
GABA mediates autoreceptor feedback inhibition in the rat carotid body via presynaptic GABAB receptors and TASK-1.
Whooping Cough
Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway.
Whooping Cough
Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Whooping Cough
Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase.
Whooping Cough
Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways.
Whooping Cough
High glucose inhibits fructose uptake in renal proximal tubule cells: involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2.
Whooping Cough
Inhibition of oxytocin-stimulated phosphoinositide turnover in rat myometrium by pertussis and cholera toxins may involve protein kinase A activation.
Whooping Cough
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes.
Whooping Cough
Involvement of a putative G-protein-coupled receptor and a branching pathway in argipressin (4-8) signal transduction in rat hippocampus.
Whooping Cough
Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line.
Whooping Cough
Involvement of cyclic adenosine monophosphate-dependent protein kinase A and pertussis toxin-sensitive G proteins in the migratory response of human CD14+ mononuclear cells to katacalcin.
Whooping Cough
Involvement of Gq/11 in both integrin signal-dependent and -independent pathways regulating endothelin-induced neural progenitor proliferation.
Whooping Cough
kappa-opioid receptor stimulation inhibits cardiac hypertrophy induced by beta1-adrenoceptor stimulation in the rat.
Whooping Cough
Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane.
Whooping Cough
Lithium activates mammalian Na+/H+ exchangers: isoform specificity and inhibition by genistein.
Whooping Cough
Low-Density Lipoprotein Induced Expression of Connective Tissue Growth Factor via Transactivation of Sphingosine 1-Phosphate Receptors in Mesangial Cells.
Whooping Cough
Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathway.
Whooping Cough
Lysophosphatidic acid-induced proliferation-related signals in astrocytes.
Whooping Cough
Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells.
Whooping Cough
Mechanisms mediating pituitary adenylate cyclase-activating polypeptide depolarization of rat sympathetic neurons.
Whooping Cough
Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT.
Whooping Cough
Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways.
Whooping Cough
Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins.
Whooping Cough
mGluR7 inhibits glutamate release through a PKC-independent decrease in the activity of P/Q-type Ca2+ channels and by diminishing cAMP in hippocampal nerve terminals.
Whooping Cough
Microbial hijacking of complement-toll-like receptor crosstalk.
Whooping Cough
Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase.
Whooping Cough
Molecular mechanisms underlying forskolin-mediated up-regulation of human dopamine D2L receptors.
Whooping Cough
Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways.
Whooping Cough
Mouse retinal ganglion cell signalling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways.
Whooping Cough
Multiple pathways of apolipoprotein E signaling in primary neurons.
Whooping Cough
Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT1A receptors.
Whooping Cough
Neuronal mechanism of nociceptin-induced modulation of learning and memory: involvement of N-methyl-D-aspartate receptors.
Whooping Cough
Neuropeptide Y inhibits axonal transport of particles in neurites of cultured adult mouse dorsal root ganglion cells.
Whooping Cough
Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones.
Whooping Cough
Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells.
Whooping Cough
Phosphatidylinositol-3 kinase is distinctively required for mu-, but not kappa-opioid receptor-induced activation of c-Jun N-terminal kinase.
Whooping Cough
Phospholipase C activity in NCB-20 cells is inhibited by protein kinase A-mediated phosphorylation of low molecular mass GTP-binding proteins.
Whooping Cough
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Whooping Cough
Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.
Whooping Cough
Raf-1 kinase activation by angiotensin II in adrenal glomerulosa cells: roles of Gi, phosphatidylinositol 3-kinase, and Ca2+ influx.
Whooping Cough
Raf-1 kinase mediates adenylyl cyclase sensitization by TNF-alpha in human airway smooth muscle cells.
Whooping Cough
Rapid and non-genomic reduction of intracellular [Ca(2+)] induced by aldosterone in human bronchial epithelium.
Whooping Cough
Regulation of expression of early growth response transcription factors in rat primary cortical neurons by extracellular ATP.
Whooping Cough
Regulation of gap-junction protein connexin 43 by beta-adrenergic receptor stimulation in rat cardiomyocytes.
Whooping Cough
Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.
Whooping Cough
Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide.
Whooping Cough
Role of GTP-binding proteins in the polyunsaturated fatty acid stimulated proliferation of mouse mammary epithelial cells.
Whooping Cough
Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: Evidence for Gi/o modulation via EP3 receptors.
Whooping Cough
Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration.
Whooping Cough
Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor.
Whooping Cough
Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1).
Whooping Cough
Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2.
Whooping Cough
Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation.
Whooping Cough
Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein.
Whooping Cough
sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation.
Whooping Cough
Stable guanosine 5'-triphosphate-analogues inhibit specific (+)-[3H]isradipine binding in rat hearts by a Ca(2+)-lowering, G protein-independent mechanism.
Whooping Cough
Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: new pharmacological profile and mechanism of activation.
Whooping Cough
Structure-activity relationship and signal transduction of gamma-MSH peptides in GH3 cells: further evidence for a new melanocortin receptor.
Whooping Cough
Testosterone rapidly increases Ca(2+)-activated K(+) currents causing hyperpolarization in human coronary artery endothelial cells.
Whooping Cough
The beta1-adrenergic receptor mediates extracellular signal-regulated kinase activation via Galphas.
Whooping Cough
The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.
Whooping Cough
The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5.
Whooping Cough
The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus.
Whooping Cough
The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway.
Whooping Cough
The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells.
Whooping Cough
The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals.
Whooping Cough
The neuropeptide pituitary adenylate cyclase activating polypeptide modulates Ca2+ and pro-inflammatory functions in human monocytes through the G protein-coupled receptors VPAC-1 and formyl peptide receptor-like 1.
Whooping Cough
The neurotransmitter glutamate reduces axonal responsiveness to multiple repellents through the activation of metabotropic glutamate receptor 1.
Whooping Cough
The proteinase-activated receptor-2 mediates phagocytosis in a Rho-dependent manner in human keratinocytes.
Whooping Cough
Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein.
Whooping Cough
WAY208466 inhibits glutamate release at hippocampal nerve terminals.
Williams Syndrome
The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3.
Wilms Tumor
Inhibition of GSK3 Represses the Expression of Retinoic Acid Synthetic Enzyme ALDH1A2 via Wnt/?-Catenin Signaling in WiT49 Cells.
Wilms Tumor
Investigation of New Therapeutic Targets in Undifferentiated Endometrial Sarcoma.
Wilms Tumor
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Wilms Tumor
MicroRNA-483-3p Promotes Proliferation, Migration, and Invasion and Induces Chemoresistance of Wilms' Tumor Cells.
Wilms Tumor
MiR-200c inhibits proliferation and promotes apoptosis of Wilms tumor cells by regulating akt signaling pathway.
Wiskott-Aldrich Syndrome
Interplay between N-WASP and CK2 optimizes clathrin-mediated endocytosis of EGFR.
Wiskott-Aldrich Syndrome
Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.
Wiskott-Aldrich Syndrome
LRRK2 and WAVE2 regulate microglial-transition through distinct morphological phenotypes to induce neurotoxicity in a novel two-hit in vitro model of neurodegeneration.
Wiskott-Aldrich Syndrome
miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function.
Wiskott-Aldrich Syndrome
Potential implications of interleukin-7 in chronic wound healing.
Wiskott-Aldrich Syndrome
Rho kinase collaborates with p21-activated kinase to regulate actin polymerization and contraction in airway smooth muscle.
Wiskott-Aldrich Syndrome
Role of Rho-GTPases in megakaryopoiesis.
Xanthomatosis
Presence of palmar xanthomas in myotonic dystrophy identifies different patterns of linkage disequilibrium between the apolipoprotein E and myotonic dystrophy protein kinase loci.
Xeroderma Pigmentosum
A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.
Xeroderma Pigmentosum
A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient.
Xeroderma Pigmentosum
Endothelin-1 and ?-melanocortin have redundant effects on global genome repair in UV-irradiated human melanocytes despite distinct signaling pathways.
Xeroderma Pigmentosum
Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells.
Xeroderma Pigmentosum
NDR1 modulates the UV-induced DNA-damage checkpoint and nucleotide excision repair.
Xeroderma Pigmentosum
Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer.
Xeroderma Pigmentosum
Phosphorylation of Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A by Ataxia Telangiectasia Mutated and Rad3-Related-Dependent Checkpoint Pathway Promotes Cell Survival in Response to UV Irradiation.
Xerostomia
MicroRNA-mRNA expression profiles and functional network of submandibular gland in type 2 diabetic db/db mice.
Yellow Fever
IDENTIFICATION AND EXPRESSION ANALYSIS OF TWO 14-3-3 PROTEINS IN THE MOSQUITO Aedes aegypti, AN IMPORTANT ARBOVIRUSES VECTOR.
Yellow Fever
The flaviviral methyltransferase is a substrate of Casein Kinase 1.
Zellweger Syndrome
A novel migration-related gene product, doublecortin, in neuronal migration disorder of fetuses and infants with Zellweger syndrome.
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