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Information on EC 2.7.11.1 - non-specific serine/threonine protein kinase

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IUBMB Comments
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
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UNIPROT: P31751
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase a, 14-3-3, camkii, p-akt, lrrk2, c-jun n-terminal kinase, serine/threonine kinase, raf-1, protein kinase b, gsk-3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
RAC-beta serine/threonine protein kinase
-
serine/threonine kinase
-
A-kinase
-
-
-
-
A-T, mutated
-
-
-
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A-T, mutated homolog
-
-
-
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AMH type II receptor
-
-
-
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Anti-sigma B factor rsbT
-
-
-
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AP50 kinase
-
-
-
-
Ataxia telangiectasia mutated
-
-
-
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Ataxia telangiectasia mutated homolog
-
-
-
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ATP-protein transphosphorylase
-
-
-
-
betaIIPKC
-
-
-
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Breast-tumor-amplified kinase
-
-
-
-
Calcium-dependent protein kinase C
-
-
-
-
Calcium/phospholipid-dependent protein kinase
-
-
-
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cAMP-dependent protein kinase A
-
-
-
-
casein kinase
-
-
-
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casein kinase 2
-
-
-
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casein kinase I
-
-
-
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casein kinase II
-
-
-
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casein kinase-2
-
-
-
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CDC25 suppressing protein kinase
-
-
-
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Cell division cycle 2-like
-
-
-
-
CK-2
-
-
-
-
CK2
-
-
-
-
CK2-alpha
-
-
-
-
CKI
-
-
-
-
CKII
-
-
-
-
CLP-36 interacting kinase
-
-
-
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cyclic monophosphate-dependent protein kinase
-
-
-
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cyclic nucleotide-dependent protein kinase
-
-
-
-
cyclin-dependent kinase
-
-
-
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cytidine 3',5'-cyclic monophosphate-responsive protein kinase
-
-
-
-
DNA-PKcs
-
-
-
-
DNPK1
-
-
-
-
dSTPK61
-
-
-
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G11 protein
-
-
-
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hARK1
-
-
-
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histone kinase
-
-
-
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hPDK1
-
-
-
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Hpr kinase
-
-
-
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hPSK
-
-
-
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HSPK 21
-
-
-
-
HSPK 36
-
-
-
-
hydroxyalkyl-protein kinase
-
-
-
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Kinase interacting with stathmin
-
-
-
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kinase, casein (phosphorylating)
-
-
-
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kinase, protamine (phosphorylating)
-
-
-
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kinase, protein (phosphorylating)
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-
-
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kinase, protein, A (phosphorylating)
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-
-
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kinase, protein, C (phosphorylating)
-
-
-
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Lymphocyte-oriented kinase
-
-
-
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M phase-specific cdc2 kinase
-
-
-
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mitogen-activated S6 kinase
-
-
-
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mPDK1
-
-
-
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MPSK
-
-
-
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Myristoylated and palmitoylated serine-threonine kinase
-
-
-
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NY-REN-55 antigen
-
-
-
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P-CIP2
-
-
-
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P460
-
-
-
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p46Eg265
-
-
-
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p46XlEg22
-
-
-
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p82 kinase
-
-
-
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pEg2
-
-
-
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phosphorylase b kinase kinase
-
-
-
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Phototropin
-
-
-
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Pim-2h
-
-
-
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PKA
-
-
-
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PkB kinase
-
-
-
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pp39-mos
-
-
-
-
Pre-mRNA protein kinase
-
-
-
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protamine kinase
-
-
-
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protein glutamyl kinase
-
-
-
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protein kinase (phosphorylating)
-
-
-
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Protein kinase B kinase
-
-
-
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protein kinase CK2
-
-
-
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Protein kinase Krct
-
-
-
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Protein kinase MST
-
-
-
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protein kinase p58
-
-
-
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Protein kinase PKL12
-
-
-
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protein phosphokinase
-
-
-
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protein serine kinase
-
-
-
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protein serine-threonine kinase
-
-
-
-
protein-aspartyl kinase
-
-
-
-
protein-cysteine kinase
-
-
-
-
protein-serine kinase
-
-
-
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protein-serine/threonine kinase
-
-
-
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PRP4 kinase
-
-
-
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PRP4 pre-mRNA processing factor 4 homolog
-
-
-
-
PSK-H1
-
-
-
-
Raf kinase
-
-
-
-
Raf-1
-
-
-
-
ratAurA
-
-
-
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ribosomal protein S6 kinase II
-
-
-
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ribosomal S6 protein kinase
-
-
-
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RP1 protein
-
-
-
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S-receptor kinase
-
-
-
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serine kinase
-
-
-
-
serine protein kinase
-
-
-
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serine(threonine) protein kinase
-
-
-
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serine-specific protein kinase
-
-
-
-
serine/threonine kinase
-
-
-
-
Serine/threonine kinase 15
-
-
-
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Serine/threonine kinase Ayk1
-
-
-
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serine/threonine protein kinase
-
-
-
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Serine/threonine-protein kinase NRK2
-
-
-
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Serine/threonine-protein kinase NYD-SPK
-
-
-
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SRK
-
-
-
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Ste20-like kinase
-
-
-
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STE20-like kinase MST1
-
-
-
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STE20-like kinase MST2
-
-
-
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STE20-like kinase MST3
-
-
-
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Switch protein/serine kinase
-
-
-
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T-antigen kinase
-
-
-
-
threonine-specific protein kinase
-
-
-
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Twitchin kinase
-
-
-
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type-2 casein kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (non-specific)
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
CAS REGISTRY NUMBER
COMMENTARY hide
191808-15-8
phosphoinositide dependent protein kinase 1
340830-03-7
-
37278-10-7
-
377752-08-4
ribosomal protein S6 kinase 2
389133-24-8
ribosomal S6 kinase 3
52660-18-1
casein kinase, protein kinase CK2
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
90698-26-3
ribosomal protein S6 kinase 1
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + glycogen synthase kinase-3 (GSK-3) fusion protein
ADP + phosphorylated- glycogen synthase kinase-3 fusion protein
show the reaction diagram
-
-
-
?
additional information
?
-
AKT2 may contribute to the pathogenesis of ovarian carcinomas
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
AKT2 may contribute to the pathogenesis of ovarian carcinomas
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Insulin
in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt2-Ser473 phosphorylation
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AKT2_HUMAN
481
0
55769
Swiss-Prot
other Location (Reliability: 3)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
Muscle cells from diabetic patients display an impaired Akt2-Ser473 phosphorylation and a higher level of the Akt2-Ser473-specific protein phosphatase PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) in muscle from diabetic patients
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cheng, J.Q.; Godwin, A.K.; Bellacosa, A.; Taguchi, T.; Franke, T.F.; Hamilton, T.C.; Tsichlis, P.N.; Testa, J.R.
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
Proc. Natl. Acad. Sci. USA
89
9267-9271
1992
Homo sapiens (P31751)
Manually annotated by BRENDA team
Jones, P.F.; Jakubowicz, T.; Hemmings, B.A.
Molecular cloning of a second form of rac protein kinase
Cell Regul.
2
1001-1009
1991
Homo sapiens (P31751), Homo sapiens
Manually annotated by BRENDA team
Cozzone, D.; Froejdoe, S.; Disse, E.; Debard, C.; Laville, M.; Pirola, L.; Vidal, H.
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients
Diabetologia
51
512-521
2008
Homo sapiens (P31749), Homo sapiens (P31751), Homo sapiens (Q9Y243), Homo sapiens
Manually annotated by BRENDA team