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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Rattus norvegicus and UniProt Accession Q924U5

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EC Tree
IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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Select one or more organisms in this record: ?
This record set is specific for:
Rattus norvegicus
UNIPROT: Q924U5
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
testis-specific protein kinase 2
-
70 kDa zeta-associated protein
-
-
-
-
A-Raf proto-oncogene serine/threonine-protein kinase
-
activin receptor type I
-
activin receptor type II
-
activin X1 receptor
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
anti-mullerian hormone type II receptor
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
-
-
-
-
C-SRC kinase
-
-
-
-
c-Src tyrosine kinase
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
JAK2 protein tyrosine kinase
-
Janus kinase
-
-
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LIM domain kinase 2
-
LSK
-
-
-
-
Lyn tyrosine kinase
-
mullerian inhibiting substance type II receptor
-
nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
proto-oncogene serine/threonine-protein kinase mos
-
proto-oncogene tyrosine-protein kinase SRC
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
-
RAF proto-oncogene serine/threonine-protein kinase
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
serine/threonine-protein kinase receptor R2
-
serine/threonine-protein kinase receptor R3
-
SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
Src tyrosine kinase
-
-
Src-family protein kinase
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
TGF-beta receptor type I
-
TGF-beta receptor type II
-
TGF-beta type II receptor
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
tyrosine kinase Fyn
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
tyrosine-protein kinase CSK
-
Tyrosine-protein kinase CTK
-
-
-
-
tyrosine-protein kinase HCK
-
tyrosine-protein kinase JAK2
-
tyrosine-protein kinase JAK3
-
Tyrosine-protein kinase Lyk
-
-
-
-
tyrosine-protein kinase LYN
-
tyrosine-protein kinase SYK
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
the enzyme induces formation of actin stress fibers and focal adhesions
-
-
?
ATP + cofilin
ADP + phosphorylated cofilin
show the reaction diagram
phosphorylation specifically at Ser-3
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
TESK1 has a specific function in spermatogenesis
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
show the reaction diagram
-
-
-
-
?
ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
show the reaction diagram
-
-
-
-
?
ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
show the reaction diagram
-
-
-
-
?
ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
show the reaction diagram
-
-
-
-
?
ATP + FAK
ADP + phospho-tyrosinyl-FAK
show the reaction diagram
-
-
-
-
?
ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
show the reaction diagram
-
-
-
-
?
ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
show the reaction diagram
-
-
-
-
?
ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
show the reaction diagram
-
-
-
-
?
ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
show the reaction diagram
-
-
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
specifically phosphorylates Tyr527 of p60c-src from neonatal rat brain, specifically phosphorylates a negative regulatory site of p60c-src
-
-
?
ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
show the reaction diagram
-
-
-
-
?
ATP + Shc protein
ADP + phospho-tyrosinyl-Shc protein
show the reaction diagram
-
-
-
-
?
ATP + STAT3
ADP + phospho-tyrosinyl-STAT3
show the reaction diagram
-
-
-
-
?
ATP + [protein kinase C zeta]-L-tyrosine
ADP + [protein kinase C zeta]-L-tyrosine phosphate
show the reaction diagram
-
Src kinase plays an important role in angiotensin II-elicited protein kinase C zeta activation and the subsequent downstream signaling including ERK1/2 activation and vascular smooth muscle cell proliferation
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
the enzyme induces formation of actin stress fibers and focal adhesions
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
TESK1 has a specific function in spermatogenesis
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
show the reaction diagram
-
-
-
-
?
ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
show the reaction diagram
-
-
-
-
?
ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
show the reaction diagram
-
-
-
-
?
ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
show the reaction diagram
-
-
-
-
?
ATP + FAK
ADP + phospho-tyrosinyl-FAK
show the reaction diagram
-
-
-
-
?
ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
show the reaction diagram
-
-
-
-
?
ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
show the reaction diagram
-
-
-
-
?
ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
show the reaction diagram
-
-
-
-
?
ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
show the reaction diagram
-
-
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
specifically phosphorylates Tyr527 of p60c-src from neonatal rat brain, specifically phosphorylates a negative regulatory site of p60c-src
-
-
?
ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
show the reaction diagram
-
-
-
-
?
ATP + Shc protein
ADP + phospho-tyrosinyl-Shc protein
show the reaction diagram
-
-
-
-
?
ATP + STAT3
ADP + phospho-tyrosinyl-STAT3
show the reaction diagram
-
-
-
-
?
ATP + [protein kinase C zeta]-L-tyrosine
ADP + [protein kinase C zeta]-L-tyrosine phosphate
show the reaction diagram
-
Src kinase plays an important role in angiotensin II-elicited protein kinase C zeta activation and the subsequent downstream signaling including ERK1/2 activation and vascular smooth muscle cell proliferation
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
PP2
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine
-
selective Src-kinase inhibitors 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine and 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine, at 5 microM, attenuate acetylcholine-induced ionic currents and intracellular Ca2+ ion concentration transients in major pelvic ganglion neurons
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine
-
-
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine
-
selective Src-kinase inhibitors 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine and 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine, at 5 microM, attenuate acetylcholine-induced ionic currents and intracellular Ca2+ ion concentration transients in major pelvic ganglion neurons
AZM 475271
-
-
CGP 76030
-
-
CGP 77675
-
-
genistein
M 475271
-
-
tyrphostin A23
-
inhibits PTKs
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
-
-
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
Rattus norvegicus
-
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2
-
phosphorylation assay
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
-
phosphorylation assay
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
predominant expression in
Manually annotated by BRENDA team
mesenchymal cells located adjacent to the mullerian ducts of males and females at day 15 of embryonic development
Manually annotated by BRENDA team
spinal microglia
Manually annotated by BRENDA team
-
ventricular
Manually annotated by BRENDA team
primary neuronal culture
Manually annotated by BRENDA team
both type II and IIB activin receptor genes are widely expressed in the male and female reproductive tissues
Manually annotated by BRENDA team
-
autonomic ganglion innervating urinary bladder
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
localized mainly in
Manually annotated by BRENDA team
-
Src family PTKs
Manually annotated by BRENDA team
-
the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TESK2_RAT
570
0
63559
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
125000
determined by SDS-PAGE and Western Blot analysis
53000
alternative splicing variant, identified by SDS-PAGE and Western blot analysis
56000
identified by SDS-PAGE and Western blot analysis
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment, SH4 is followed by the regulatory SH3 and SH2 domains, which are highly conserved and bind proline-rich and phosphotyrosyl regions, respectively
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in COS cells
isolation of cDNA
transfected into Chinese hamster ovary cells
two species of type II activin receptor, ActROO and ActRIIB
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
at the mRNA level, JAK1 is significantly increased in rats with nephropathy induced by unilateral nephrectomy and a single tail vein injection of adriamycin (5 mg/kg) in week 2, whereas JAK2 mRNA shows a significant decrease by weeks 2 and 4, followed by an significant increase in week 6
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
pharmacology
-
the enzyme is a pharmaceutical target for inhibitors in therapy of acute inflammatory responses, e.g. acute lung injury, ischemic brain injury, brain injury, spinal cord compression, stroke, and myocardial infarction, detailed overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Danio rerio (O12990), Danio rerio (O93596), Mus musculus (P00520), Mus musculus (Q9R117), Drosophila melanogaster (P00528), Drosophila melanogaster (P18106), Drosophila melanogaster (Q24145), Drosophila melanogaster (Q9V9J3), Homo sapiens (P06239), Homo sapiens (Q06187), Macaca fascicularis (Q95M30), Rattus norvegicus (Q9WUD9)
Manually annotated by BRENDA team
Rider, L.G.; Raben, N.; Miller, L.; Jelsema, C.
The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells
Gene
138
219-222
1994
Homo sapiens (P07948), Homo sapiens, Rattus norvegicus (Q07014)
Manually annotated by BRENDA team
Nada, S.; Okada, M.; MacAuley, A.; Cooper, J.A.; Nakagawa, H.
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src
Nature
351
69-72
1991
Rattus norvegicus (P32577)
Manually annotated by BRENDA team
Okada, M.; Nada, S.; Yamanashi, Y.; Yamamoto, T.; Nakagawa, H.
CSK: a protein-tyrosine kinase involved in regulation of src family kinases
J. Biol. Chem.
266
24249-24252
1991
Rattus norvegicus (P32577)
Manually annotated by BRENDA team
Kuo, S.S.; Moran, P.; Gripp, J.; Armanini, M.; Phillips, H.S.; Goddard, A.; Caras, I.W.
Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk
J. Neurosci. Res.
38
705-715
1994
Rattus norvegicus (P41243)
Manually annotated by BRENDA team
Okano, Y.; Sugimoto, Y.; Fukuoka, M.; Matsui, A.; Nagata, K.; Nozawa, Y.
Identification of rat cDNA encoding hck tyrosine kinase from megakaryocytes
Biochem. Biophys. Res. Commun.
181
1137-1144
1991
Rattus norvegicus (P50545)
Manually annotated by BRENDA team
Nunoue, K.; Ohashi, K.; Okano, I.; Mizuno, K.
LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family
Oncogene
11
701-710
1995
Rattus norvegicus (P53670)
Manually annotated by BRENDA team
Vonakis, B.M.; Chen, H.; Haleem-Smith, H.; Metzger, H.
The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE
J. Biol. Chem.
272
24072-24080
1997
Rattus norvegicus (Q07014)
Manually annotated by BRENDA team
Duhe, R.J.; Rui, H.; Greenwood, J.D.; Garvey, K.; Farrar, W.L.
Cloning of the gene encoding rat JAK2, a protein tyrosine kinase
Gene
158
281-285
1995
Rattus norvegicus (Q62689)
Manually annotated by BRENDA team
Takahashi, T.; Shirasawa, T.
Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases
FEBS Lett.
342
124-128
1994
Rattus norvegicus (Q63272)
Manually annotated by BRENDA team
Rowley, R.B.; Bolen, J.B.; Fargnoli, J.
Molecular cloning of rodent p72Syk. Evidence of alternative mRNA splicing
J. Biol. Chem.
270
12659-12664
1995
Rattus norvegicus (Q64725)
Manually annotated by BRENDA team
Burgaya, F.; Girault, J.A.
Cloning of focal adhesion kinase, pp125FAK, from rat brain reveals multiple transcripts with different patterns of expression
Brain Res. Mol. Brain Res.
37
63-73
1996
Rattus norvegicus (O35346)
Manually annotated by BRENDA team
O'Donovan, C.; Martin, M.J.; Gattiker, A.; Gasteiger, E.; Bairoch, A.; Apweiler, R.
High quality protein knowledge resources: Swiss-Prot and TrEMBL
Brief. Bioinform.
2
275-284
2002
Rattus norvegicus (P70600), Homo sapiens (Q14289)
-
Manually annotated by BRENDA team
Teixeira, J.; Kehas, D.J.; Antun, R.; Donahoe, P.K.
Transcriptional regulation of the rat Mullerian inhibiting substance type II receptor in rodent Leydig cells
Proc. Natl. Acad. Sci. USA
96
13831-13838
1999
Rattus norvegicus (Q62893)
Manually annotated by BRENDA team
Teixeira, J.; He, W.W.; Shah, P.C.; Morikawa, N.; Lee, M.M.; Catlin, E.A.; Hudson, P.L.; Wing, J.; Maclaughlin, D.T.; Donahoe, P.K.
Developmental expression of a candidate mullerian inhibiting substance type II receptor
Endocrinology
137
160-165
1996
Rattus norvegicus (Q62893)
Manually annotated by BRENDA team
Takumi, T.; Moustakas, A.; Lin, H.Y.; Lodish, H.F.
Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line GH3
Exp. Cell Res.
216
208-214
1995
Rattus norvegicus (P80202)
Manually annotated by BRENDA team
Baarends, W.M.; van Helmond, M.J.; Post, M.; van der Schoot, P.J.; Hoogerbrugge, J.W.; de Winter, J.P.; Uilenbroek, J.T.; Karels, B.; Wilming, L.G.; Meijers, J.H.; et al.
A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the mullerian duct
Development
120
189-197
1994
Rattus norvegicus (Q62893)
Manually annotated by BRENDA team
Tsuchida, K.; Lewis, K.A.; Mathews, L.S.; Vale, W.W.
Molecular characterization of rat transforming growth factor-beta type II receptor
Biochem. Biophys. Res. Commun.
191
790-795
1993
Rattus norvegicus (P38438)
Manually annotated by BRENDA team
Tsuchida, K.; Mathews, L.S.; Vale, W.W.
Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor
Proc. Natl. Acad. Sci. USA
90
11242-11246
1993
Rattus norvegicus (P80201)
Manually annotated by BRENDA team
He, W.W.; Gustafson, M.L.; Hirobe, S.; Donahoe, P.K.
Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family
Dev. Dyn.
196
133-142
1993
Rattus norvegicus (P80201), Rattus norvegicus (P80202), Rattus norvegicus (P80203), Rattus norvegicus (P80204)
Manually annotated by BRENDA team
Feng, Z.M.; Madigan, M.B.; Chen, C.L.
Expression of type II activin receptor genes in the male and female reproductive tissues of the rat
Endocrinology
132
2593-2600
1993
Rattus norvegicus (P38444)
Manually annotated by BRENDA team
Choi, M.E.; Kim, E.G.; Huang, Q.; Ballermann, B.J.
Rat mesangial cell hypertrophy in response to transforming growth factor-beta 1
Kidney Int.
44
948-958
1993
Rattus norvegicus (P38438)
Manually annotated by BRENDA team
Shinozaki, H.; Ito, I.; Hasegawa, Y.; Nakamura, K.; Igarashi, S.; Nakamura, M.; Miyamoto, K.; Eto, Y.; Ibuki, Y.; Minegishi, T.
Cloning and sequencing oa rat type II activin receptor
FEBS Lett.
312
53-56
1992
Rattus norvegicus (P38444)
Manually annotated by BRENDA team
Leibovitch, S.A.; Lenormand, J.L.; Leibovitch, M.P.; Guiller, M.; Mallard, L.; Harel, J.
Rat myogenic c-mos cDNA: cloning sequence analysis and regulation during muscle development
Oncogene
5
1149-1157
1990
Rattus norvegicus (P00539)
Manually annotated by BRENDA team
Van der Hoorn, F.A.; Firzlaff, J.
Complete c-mos (rat) nucleotide sequence: presence of conserved domains in c-mos proteins
Nucleic Acids Res.
12
2147-2156
1984
Rattus norvegicus (P00539)
Manually annotated by BRENDA team
Toshima, J.; Ohashi, K.; Okano, I.; Nunoue, K.; Kishioka, M.; Kuma, K.; Miyata, T.; Hirai, M.; Baba, T.; Mizuno, K.
Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells
J. Biol. Chem.
270
31331-31337
1995
Homo sapiens (Q15569), Homo sapiens, Rattus norvegicus (Q63572)
Manually annotated by BRENDA team
Toshima, J.; Toshima, J.Y.; Takeuchi, K.; Mori, R.; Mizuno, K.
Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells
J. Biol. Chem.
276
31449-31458
2001
Rattus norvegicus (Q924U5), Homo sapiens (Q96S53)
Manually annotated by BRENDA team
Ishikawa, F.; Takaku, F.; Nagao, M.; Sugimura, T.
Rat c-raf oncogene activation by a rearrangement that produces a fused protein
Mol. Cell. Biol.
7
1226-1232
1987
Rattus norvegicus (P11345)
Manually annotated by BRENDA team
Terada, T.; Ito, Y.; Shirouzu, M.; Tateno, M.; Hashimoto, K.; Kigawa, T.; Ebisuzaki, T.; Takio, K.; Shibata, T.; Yokoyama, S.; Smith, B.O.; Laue, E.D.; Cooper, J.A.
Nuclear magnetic resonance and molecular dynamics studies on the interactions of the Ras-binding domain of Raf-1 with wild-type and mutant Ras proteins
J. Mol. Biol.
286
219-232
1999
Rattus norvegicus (P11345)
Manually annotated by BRENDA team
Ishikawa, F.; Takaku, F.; Nagao, M.; Sugimura, T.
The complete primary structure of the rat A-raf cDNA coding region: conservation of the putative regulatory regions present in rat c-raf
Oncogene Res.
1
243-253
1987
Rattus norvegicus (P14056)
Manually annotated by BRENDA team
Gao, Z.; Lau, C.P.; Wong, T.M.; Li, G.R.
Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes
Cell. Signal.
16
333-341
2004
Rattus norvegicus
Manually annotated by BRENDA team
Ovrevik, J.; Lag, M.; Schwarze, P.; Refsnes, M.
p38 and Src-ERK1/2 pathways regulate crystalline silica-induced chemokine release in pulmonary epithelial cells
Toxicol. Sci.
81
480-490
2004
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Okutani, D.; Lodyga, M.; Han, B.; Liu, M.
Src protein tyrosine kinase family and acute inflammatory responses
Am. J. Physiol. Lung Cell Mol. Physiol.
291
L129-L141
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Ulanova, M.; Asfaha, S.; Stenton, G.; Lint, A.; Gilbertson, D.; Schreiber, A.; Befus, D.
Involvement of Syk protein tyrosine kinase in LPS-induced responses in macrophages
J. Endotoxin Res.
13
117-125
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Pereira, D.B.; Chao, M.V.
The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts
J. Neurosci.
27
4859-4869
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Tsuda, M.; Tozaki-Saitoh, H.; Masuda, T.; Toyomitsu, E.; Tezuka, T.; Yamamoto, T.; Inoue, K.
Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury
Glia
56
50-58
2008
Mus musculus (P25911), Rattus norvegicus (Q07014)
Manually annotated by BRENDA team
Alvarez, S.E.; Seguin, L.R.; Villarreal, R.S.; Nahmias, C.; Ciuffo, G.M.
Involvement of c-Src tyrosine kinase in SHP-1 phosphatase activation by Ang II AT2 receptors in rat fetal tissues
J. Cell. Biochem.
105
703-711
2008
Rattus norvegicus
Manually annotated by BRENDA team
Shani, V.; Bromberg, Y.; Sperling, O.; Zoref-Shani, E.
Involvement of Src Tyrosine Kinases (SFKs) and of Focal Adhesion Kinase (FAK) in the injurious mechanism in rat primary neuronal cultures exposed to chemical ischemia
J. Mol. Neurosci.
37
50-59
2009
Rattus norvegicus, Rattus norvegicus (O35346)
Manually annotated by BRENDA team
Tsuruno, S.; Kawaguchi, S.Y.; Hirano, T.
Src-family protein tyrosine kinase negatively regulates cerebellar long-term depression
Neurosci. Res.
61
329-332
2008
Rattus norvegicus (Q9WUD9)
Manually annotated by BRENDA team
Liang, Y.; Jin, Y.; Li, Y.
Expression of JAKs/STATs pathway molecules in rat model of rapid focal segmental glomerulosclerosis
Pediatr. Nephrol.
24
1661-1671
2009
Rattus norvegicus
Manually annotated by BRENDA team
Kim, N.H.; Park, K.S.; Cha, S.K.; Yoon, J.H.; Yeh, B.I.; Han, K.H.; Kong, I.D.
Src family kinase potentiates the activity of nicotinic acetylcholine receptor in rat autonomic ganglion innervating urinary bladder
Neurosci. Lett.
494
190-195
2011
Rattus norvegicus
Manually annotated by BRENDA team
Li, L.; Zhou, Y.; Wang, C.; Zhao, Y.L.; Zhang, Z.G.; Fan, D.; Cui, X.B.; Wu, L.L.
Src tyrosine kinase regulates angiotensin II-induced protein kinase Czeta activation and proliferation in vascular smooth muscle cells
Peptides
31
1159-1164
2010
Rattus norvegicus (Q9WUD9)
Manually annotated by BRENDA team
Ge, H.; Zhao, M.; Lee, S.; Xu, Z.
Mitochondrial Src tyrosine kinase plays a role in the cardioprotective effect of ischemic preconditioning by modulating complex I activity and mitochondrial ROS generation
Free Radic. Res.
49
1210-1217
2015
Rattus norvegicus
Manually annotated by BRENDA team