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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Gallus gallus and UniProt Accession Q05876

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EC Tree
IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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This record set is specific for:
Gallus gallus
UNIPROT: Q05876
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proto-oncogene tyrosine-protein kinase FYN
-
70 kDa zeta-associated protein
-
-
-
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
bone morphogenetic protein receptor type IB
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LIM domain kinase 2
-
LIM-kinase
-
LSK
-
-
-
-
nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
-
-
-
-
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
proto-oncogene serine/threonine-protein kinase mos
-
proto-oncogene tyrosine-protein kinase LCK
-
proto-oncogene tyrosine-protein kinase SRC
-
proto-oncogene tyrosine-protein kinase YES
-
proto-oncogene tyrosine-protein kinase YRK
-
PTK
-
-
-
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
Src protein-tyrosine kinase
-
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
tyrosine-protein kinase CSK
-
Tyrosine-protein kinase CTK
-
-
-
-
Tyrosine-protein kinase Lyk
-
-
-
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
Yes-related kinase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
AEEEIYGEFEAKKKK + ATP
? + ADP
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
it is likely that LIMK is involved in developmental or oncogenic processes through interactions with these LIM-containing proteins
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
phosphorylates the regulatory C-terminal tyrosine residue present on cytoplasmic tyrosine kinases of the Src family
-
-
?
denatured enolase + ATP
phosphorylated denatured enolase + ADP
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
it is likely that LIMK is involved in developmental or oncogenic processes through interactions with these LIM-containing proteins
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
phosphorylates the regulatory C-terminal tyrosine residue present on cytoplasmic tyrosine kinases of the Src family
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
-
as MgATP2-, binding site structure
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
as MgATP2-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Gleevec
also known as STI-571 or imatinib
p-fluorosulfonylbenzoyl 5'-adenosine
inactivates tyrosine protein kinase activity of p60src by reacting with lysine 295
additional information
completely inhibited by an excess of substrate peptide
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
the overall activity kcat of the catalytic domain Src, Src-CD, including the C-terminal tail for two exogenous substrates, the Src substrate peptide AEEEIYGEFEAKKKK and denatured enolase is about 10 times higher than that of wild-type Src. The kcat values for phosphorylation of the Src substrate peptide are similar for the unphosphorylated and monophosphorylated Src-CD, 50 min-1, but the apparent Km values differ significantly, approximately 0.003 mM and 0.010 mM, respectively
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
the overall activity kcat of the catalytic domain Src, Src-CD, including the C-terminal tail for two exogenous substrates, the Src substrate peptide AEEEIYGEFEAKKKK and denatured enolase is about 10 times higher than that of wild-type Src. The kcat values for phosphorylation of the Src substrate peptide are similar for the unphosphorylated and monophosphorylated Src-CD, 50 min-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
faintly expressed
Manually annotated by BRENDA team
expression at low level
Manually annotated by BRENDA team
faintly expressed
Manually annotated by BRENDA team
faintly expressed
Manually annotated by BRENDA team
expression in T lymphocytes but not in B lymphocytes
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FYN_CHICK
534
0
60265
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60911
x * 60911, calculation from nucleotide sequence
additional information
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 60911, calculation from nucleotide sequence
additional information
-
enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
enzyme autophosphorylates at the activation loop for activation, inhibition by phosphorylation at the regulatory tyrosine residue, phosphorylation sites, detailed overview
side-chain modification
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with gleevec
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
catalytic domain Src including the C-terminal tail Src-CD, expressed in Schizosaccharomyces pombe
crystal structure of chicken Src which is phosphorylated at Tyr527
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
analysis of cDNAs of the proto-oncogene c-src
catalytic domain Src including the C-terminal tail Src-CD, expressed in Schizosaccharomyces pombe
isolation of cDNA
unique domain of the yrk protein expressed in bacteria
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cooper, J.A.; Gould, K.L.; Cartwright, C.A.; Hunter, T.
Tyr527 is phosphorylated in pp60c-src: implications for regulation
Science
231
1431-1434
1986
Gallus gallus (P00523)
Manually annotated by BRENDA team
Dorai, T.; Levy, J.B.; Kang, L.; Brugge, J.S.; Wang, L.H.
Analysis of cDNAs of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the genesis of the 3' end of v-src
Mol. Cell. Biol.
11
4165-4176
1991
Gallus gallus (P00523), Gallus gallus
Manually annotated by BRENDA team
Feng, S.; Chen, J.K.; Yu, H.; Simon, J.A.; Schreiber, S.L.
Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions
Science
266
1241-1247
1994
Gallus gallus (P00523)
Manually annotated by BRENDA team
Gould, K.L.; Woodgett, J.R.; Cooper, J.A.; Buss, J.E.; Shalloway, D.; Hunter, T.
Protein kinase C phosphorylates pp60src at a novel site
Cell
42
849-857
1985
Gallus gallus (P00523)
Manually annotated by BRENDA team
Kamps, M.P.; Taylor, S.S.; Sefton, B.M.
Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites
Nature
310
589-592
1984
Gallus gallus (P00523)
Manually annotated by BRENDA team
Smart, J.E.; Oppermann, H.; Czernilofsky, A.P.; Purchio, A.F.; Erikson, R.L.; Bishop, J.M.
Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src)
Proc. Natl. Acad. Sci. USA
78
6013-6017
1981
Gallus gallus (P00523)
Manually annotated by BRENDA team
Takeya, T.; Hanafusa, H.
Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus
Cell
32
881-890
1983
Gallus gallus (P00523), Gallus gallus, Rous sarcoma virus (P00526), Rous sarcoma virus
Manually annotated by BRENDA team
Weijland, A.; Neubauer, G.; Courtneidge, S.A.; Mann, M.; Wierenga, R.K.; Superti-Furga, G.
The purification and characterization of the catalytic domain of Src expressed in Schizosaccharomyces pombe. Comparison of unphosphorylated and tyrosine phosphorylated species
Eur. J. Biochem.
240
756-764
1996
Gallus gallus (P00523)
Manually annotated by BRENDA team
Williams, J.C.; Weijland, A.; Gonfloni, S.; Thompson, A.; Courtneidge, S.A.; Superti-Furga, G.; Wierenga, R.K.
The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions
J. Mol. Biol.
274
757-775
1997
Gallus gallus (P00523), Gallus gallus
Manually annotated by BRENDA team
Yu, H.; Rosen, M.K.; Schreiber, S.L.
1H and 15N assignments and secondary structure of the Src SH3 domain
FEBS Lett.
324
87-92
1993
Gallus gallus (P00523)
Manually annotated by BRENDA team
Marcelle, C.; Eichmann, A.
Molecular cloning of a family of protein kinase genes expressed in the avian embryo
Oncogene
7
2479-2487
1992
Gallus gallus (P09324)
Manually annotated by BRENDA team
Sudol, M.; Kieswetter, C.; Zhao, Y.H.; Dorai, T.; Wang, L.H.; Hanafusa, H.
Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison with the viral yes gene
Nucleic Acids Res.
16
9876
1988
Gallus gallus (P09324)
Manually annotated by BRENDA team
Zheng, X.F.; Podell, S.; Sefton, B.M.; Kaplan, P.L.
The sequence of chicken c-yes and p61c-yes
Oncogene
4
99-104
1989
Gallus gallus (P09324), Gallus gallus
Manually annotated by BRENDA team
Sabe, H.; Knudsen, B.; Okada, M.; Nada, S.; Nakagawa, H.; Hanafusa, H.
Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein
Proc. Natl. Acad. Sci. USA
89
2190-2194
1992
Gallus gallus (P41239), Gallus gallus
Manually annotated by BRENDA team
Chow, L.M.; Ratcliffe, M.J.; Veillette, A.
Tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene
Mol. Cell. Biol.
12
1226-1233
1992
Gallus gallus (P42683), Gallus gallus
Manually annotated by BRENDA team
Strebhardt, K.; Mullins, J.I.; Bruck, C.; Rubsamen-Waigmann, H.
Additional member of the protein-tyrosine kinase family: the src- and lck-related protooncogene c-tkl
Proc. Natl. Acad. Sci. USA
84
8778-8782
1987
Gallus gallus (P42683), Gallus gallus
Manually annotated by BRENDA team
Sudol, M.; Greulich, H.; Newman, L.; Sarkar, A.; Sukegawa, J.; Yamamoto, T.
A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues
Oncogene
8
823-831
1993
Gallus gallus (Q02977), Gallus gallus (Q05876), Gallus gallus
Manually annotated by BRENDA team
Schaller, M.D.; Borgman, C.A.; Parson, J.T.
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK
Mol. Cell. Biol.
13
785-791
1993
Gallus gallus (Q92063), Gallus gallus
Manually annotated by BRENDA team
Devor, B.B.; Zhang, X.; Patel, S.K.; Polte, T.R.; Hanks, S.K.
Chicken and mouse focal adhesion kinases are similar in structure at their amino termini
Biochem. Biophys. Res. Commun.
190
1084-1089
1993
Gallus gallus (Q00944), Gallus gallus
Manually annotated by BRENDA team
Schaller, M.D.; Borgman, C.A.; Cobb, B.S.; Vines, R.R.; Reynolds.A.B.; Parsons, J.T.
Pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions
Proc. Natl. Acad. Sci. USA
89
5192-5196
1992
Gallus gallus (Q00944), Gallus gallus
Manually annotated by BRENDA team
Sumitomo, S.; Saito, T.; Nohno, T.
A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta
DNA Seq.
3
297-302
1993
Gallus gallus (Q05438)
Manually annotated by BRENDA team
Schmidt, M.; Oskarsson, M.K.; Dunn, J.K.; Blair, D.G.; Hughes, S.; Propst, F.; Vande Woude, G.F.
Chicken homolog of the mos proto-oncogene
Mol. Cell. Biol.
8
923-929
1988
Gallus gallus (P10741)
Manually annotated by BRENDA team
Ohashi, K.; Toshima, J.; Tajinda, K.; Nakamura, T.; Mizuno, K.
Molecular cloning of a chicken lung cDNA encoding a novel protein kinase with N-terminal two LIM/double zinc finger motifs
J. Biochem.
116
636-642
1994
Gallus gallus (P53666), Gallus gallus
Manually annotated by BRENDA team
Roskoski, R.Jr.
Src protein-tyrosine kinase structure and regulation
Biochem. Biophys. Res. Commun.
324
1155-1164
2004
Gallus gallus, Homo sapiens, Rous sarcoma virus
Manually annotated by BRENDA team
Lin, Y.L.; Roux, B.
Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases
J. Am. Chem. Soc.
135
14741-14753
2013
Mus musculus (P00520), Gallus gallus (P00523), Homo sapiens (P06239)
Manually annotated by BRENDA team