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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Rous sarcoma virus and UniProt Accession P25020

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EC Tree
IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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This record set is specific for:
Rous sarcoma virus
UNIPROT: P25020
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Word Map
The taxonomic range for the selected organisms is: Rous sarcoma virus
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tyrosine-protein kinase transforming protein SRC
-
70 kDa zeta-associated protein
-
-
-
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
-
-
-
-
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LSK
-
-
-
-
nonreceptor protein tyrosine kinase
-
-
-
-
nonreceptor tyrosine kinase Src
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
-
-
-
-
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
-
-
-
-
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
PTK
-
-
-
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
Src protein-tyrosine kinase
-
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
Tyrosine-protein kinase CTK
-
-
-
-
Tyrosine-protein kinase Lyk
-
-
-
-
tyrosine-protein kinase transforming protein SRC
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
-
as MgATP2-, binding site structure
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
as MgATP-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
enzyme autophosphorylates at the activation loop for activation, inhibition by phosphorylation at the regulatory tyrosine residue, phosphorylation sites, detailed overview
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides, X-ray crystallography at resolutions of 1.5 and 2.0 A
crystal structure of the Src SH2 domain complexed with a high affinity 11-residue phosphopeptide, determined at 2.7 A resolution by X-ray diffraction. Crystal structure of Src SH2 in the absence of peptide, determined at 2.5 A resolution
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takeya, T.; Hanafusa, H.
Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus
Cell
32
881-890
1983
Gallus gallus (P00523), Gallus gallus, Rous sarcoma virus (P00526), Rous sarcoma virus
Manually annotated by BRENDA team
Barnier, J.V.; Dezelee, P.; Marx, M.; Calothy, G.
Nucleotide sequence of the src gene of the Schmidt-Ruppin strain of Rous sarcoma virus type E
Nucleic Acids Res.
17
1252
1989
Rous sarcoma virus (P00526)
Manually annotated by BRENDA team
Czernilofsky, A.P.; Levinson, A.D.; Varmus, H.E.; Bishop, J.M.; Tischer, E.; Goodman, H.
Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus
Nature
301
736-738
1983
Rous sarcoma virus (P00526)
Manually annotated by BRENDA team
Neil, J.C.; Ghysdael, J.; Vogt, P.K.; Smart, J.E.
Homologous tyrosine phosphorylation sites in transformation-specific gene products of distinct avian sarcoma viruses
Nature
291
675-677
1981
Avian sarcoma virus (P00525), Rous sarcoma virus (P00526), Rous sarcoma virus Prague C (P00526)
Manually annotated by BRENDA team
Plummer, M.S.; Holland, D.R.; Shahripour, A.; Lunney, E.A.; Fergus, J.H.; Marks, J.S.; McConnell, P.; Mueller, W.T.; Sawyer, T.K.
Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand
J. Med. Chem.
40
3719-3725
1997
Rous sarcoma virus (P00526)
Manually annotated by BRENDA team
Waksman, G.; Kominos, D.; Robertson, S.C.; Pant, N.; Baltimore, D.; Birge, R.B.; Cowburn, D.; Hanafusa, H.; Mayer, B.J.; Overduin, M.; et al.
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
Nature
358
646-653
1992
Rous sarcoma virus (P00526)
Manually annotated by BRENDA team
Waksman, G.; Shoelson, S.E.; Pant, N.; Cowburn, D.; Kuriyan, J.
Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms
Cell
72
779-790
1993
Rous sarcoma virus (P00526)
Manually annotated by BRENDA team
Schwartz, D.E.; Tizard, R.; Gilbert, W.
Nucleotide sequence of Rous sarcoma virus
Cell
32
853-869
1983
Rous sarcoma virus (P00526)
Manually annotated by BRENDA team
Bodor, J.; Poliak, E.; Pichrtova, J.; Geryk, J.; Svoboda, J.
Complete nucleotide sequence of LTR, v-src, LTR provirus H-19
Nucleic Acids Res.
17
8869
1989
Rous sarcoma virus (P25020), Rous sarcoma virus H-19 (P25020)
Manually annotated by BRENDA team
Dezelee, P.; Barnier, J.V.; Hampe, A.; Laugier, D.; Marx, M.; Galibert, F.; Calothy, G.
Small deletion in v-src SH3 domain of a transformation defective mutant of Rous sarcoma virus restores wild type transforming properties
Virology
189
556-567
1992
Rous sarcoma virus (P31693), Rous sarcoma virus
Manually annotated by BRENDA team
Kashuba, V.I.; Kavsan, V.M.; Ryndich, A.V.; Lazurkevich, Z.V.; Zubak, S.V.; Popov, S.V.; Dostalova, V.; Glozhanek, I.
Complete nucleotide sequence of Rous sarcoma virus variants adapted to duck cells
Mol. Biol.
27
436-450
1993
Rous sarcoma virus (Q07461)
-
Manually annotated by BRENDA team
Roskoski, R.Jr.
Src protein-tyrosine kinase structure and regulation
Biochem. Biophys. Res. Commun.
324
1155-1164
2004
Gallus gallus, Homo sapiens, Rous sarcoma virus
Manually annotated by BRENDA team