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IUBMB CommentsUnlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase,
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tyrosine-protein kinase transforming protein fms
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70 kDa zeta-associated protein
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Agammaglobulinaemia tyrosine kinase
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Amylovoran biosynthesis membrane-associated protein amsA
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B cell progenitor kinase
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B lymphocyte kinase
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B-cell/myeloid kinase
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BCR-ABL tyrosine kinase
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BMP type II receptor
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BMP-2/BMP-4 receptor
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Bone marrow kinase BMX
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Breast tumor kinase
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Bruton's tyrosine kinase
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Calcium-dependent tyrosine kinase
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Cell adhesion kinase beta
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ectoprotein kinase
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Epithelial and endothelial tyrosine kinase
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EPS I polysaccharide export protein epsB
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focal adhesion kinase 1
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gene lck protein kinase
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gene lck tyrosine kinase
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Hematopoietic consensus tyrosine-lacking kinase
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Hemopoietic cell kinase
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IL-2-inducible T-cell kinase
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JAK protein tyrosine kinase
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kinase, protein (phosphorylating tyrosine)
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kinase, protein p56lck (phosphorylating)
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Lck Tyrosine kinase
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Leukocyte janus kinase
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nonreceptor protein tyrosine kinase
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Nuclear tyrosine protein kinase RAK
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p56lck protein kinase
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p56lck protein tyrosine kinase
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p56lck tyrosine kinase
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phosphotyrosyl-protein kinase
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Protein kinase (tyrosine-phosphorylating)
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Protein kinase BATK
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Protein kinase HYL
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Protein kinase Lck
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Protein kinase NTK
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Protein kinase p56-LCK
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Protein kinase p56lck
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Protein p56c-lck kinase
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Protein p56lck tyrosine kinase
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Protein tyrosine kinase
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protein tyrosine kinase 2beta
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Protein tyrosine kinase lck
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Protein tyrosine kinase p56lck
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Protein tyrosine kinase pp56lck
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Protein-tyrosine kinase C-TKL
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Protein-tyrosine kinase CYL
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Related adhesion focal tyrosine kinase
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Resting lymphocyte kinase
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S-domain receptor-like protein kinase
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Spleen tyrosine kinase
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SRC-related intestinal kinase
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Syk-related tyrosine kinase
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T cell-specific protein-tyrosine kinase
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T-cell-specific kinase
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Tyrosine kinase ARG
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Tyrosine kinase lck
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Tyrosine kinase p56lck
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Tyrosine phosphokinase
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Tyrosine protein kinase
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Tyrosine protein kinase p56lck
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Tyrosine-protein kinase brk
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Tyrosine-protein kinase CTK
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Tyrosine-protein kinase Lyk
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tyrosine-protein kinase transforming protein ABL
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tyrosine-protein kinase transforming protein FES
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tyrosine-protein kinase transforming protein FGR
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Tyrosine-protein kinase TYRO 10
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Tyrosine-specific protein kinase
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Tyrosylprotein kinase
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v-fps Protein-tyrosine kinase
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YES related kinase
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additional information
cellular counterpart of the viral v-fms oncogene product, the c-fms product, is the receptor for colony-stimulating factor 1 of macrophages, CSF-1. CSF-1 appeares to activate the serine/threonine kinase
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additional information
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cellular counterpart of the viral v-fms oncogene product, the c-fms product, is the receptor for colony-stimulating factor 1 of macrophages, CSF-1. CSF-1 appeares to activate the serine/threonine kinase
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additional information
sequence of the transforming polyprotein of the McDonough strain of feline sarcoma virus includes 231 nucleotides specifying a leader peptide, 1,377 nucleotides encoding most of the feline leukemia virus-derived gag gene, and 2,969 nucleotides representing the viral transforming gene v-fms
additional information
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sequence of the transforming polyprotein of the McDonough strain of feline sarcoma virus includes 231 nucleotides specifying a leader peptide, 1,377 nucleotides encoding most of the feline leukemia virus-derived gag gene, and 2,969 nucleotides representing the viral transforming gene v-fms
additional information
the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase
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Hampe, A.; Laprevotte, I.; Galibert, F.; Fedele, L.A.; Sherr, C.J.
Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes
Cell
30
775-785
1982
Feline sarcoma virus (P00542), Feline sarcoma virus (P00543), Feline sarcoma virus, Feline sarcoma virus Gardner-Arnstein (P00542), Feline sarcoma virus Snyder-Theilen (P00543)
brenda
Hampe, A.; Gobet, M.; Sherr, C.J.; Galibert, F.
Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases
Proc. Natl. Acad. Sci. USA
81
85-89
1984
Feline sarcoma virus (P00545), Feline sarcoma virus, Feline sarcoma virus McDonough (P00545)
brenda
Smola, U.; Hennig, D.; Hadwiger-Fangmeier, A.; Schutz, B.; Pfaff, E.; Niemann, H.; Tamura, T.
Reassessment of the v-fms sequence: threonine phosphorylation of the COOH-terminal domain
J. Virol.
65
6181-6187
1991
Feline sarcoma virus (P00545), Feline sarcoma virus
brenda
Semba, K.; Kamata, N.; Toyoshima, K.; Yamamoto, T.
A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma
Proc. Natl. Acad. Sci. USA
82
6497-6501
1985
Feline sarcoma virus (P00544), Feline sarcoma virus Gardner-Rasheed (P00544)
brenda
Bergold, P.J.; Blumenthal, J.A.; D'Andrea, E.; Snyder, H.W.; Lederman, L.; Silverstone, A.; Nguyen, H.; Besmer, P.
Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert
J. Virol.
61
1193-1202
1987
Feline sarcoma virus (P10447), Feline sarcoma virus, Feline sarcoma virus Hardy-Zuckerman 2 (P10447)
brenda