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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Feline sarcoma virus and UniProt Accession P00544
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2.7.10.2 non-specific protein-tyrosine kinaseIUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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Word Map
- 2.7.10.2
- leukemia
- imatinib
- lymphocytic
- integrins
-
myelogenous
- metastasis
- t-cells
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cytogenetic
-
philadelphia
- mapks
- lymphoma
- sh2
- cytoskeleton
- erk
- phosphatidylinositol
- lymphoblastic
- adhesions
-
signal-regulated
-
myeloproliferative
- 3-kinase
- autophosphorylation
- paxillin
- dasatinib
- hematologic
- collagen
-
stats
-
remiss
- arthritis
- fibronectin
- neoplasm
-
relapse
-
tyrosine-phosphorylated
- oncoproteins
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platelet-derived
- pkc
- phosphotyrosine
-
rheumatoid
-
dominant-negative
- adaptor
- mesylate
-
allogeneic
- factor-beta
-
breakpoints
-
integrin-mediated
- cd4
- crisis
- c-kit
-
activins
- drug development
- synthesis
- medicine
- analysis
- pharmacology
- pdgfr
-
kinase-dependent
The taxonomic range for the selected organisms is: Feline sarcoma virus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
70 kDa zeta-associated protein
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ACTR-IIB
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ACTRIIA
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Agammaglobulinaemia tyrosine kinase
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Amylovoran biosynthesis membrane-associated protein amsA
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ATK
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B cell progenitor kinase
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B lymphocyte kinase
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B-cell/myeloid kinase
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BCR-ABL tyrosine kinase
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BMK
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BMP type II receptor
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BMP-2/BMP-4 receptor
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Bone marrow kinase BMX
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BPK
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Breast tumor kinase
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Bruton's tyrosine kinase
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c-ABL
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c-FER
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C-FES
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C-SRC
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C-SRC kinase
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C-YES
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CADTK
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CAK beta
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Calcium-dependent tyrosine kinase
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Cell adhesion kinase beta
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D-ash
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DFer
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Dsrc28C
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ectoprotein kinase
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Epithelial and endothelial tyrosine kinase
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EPS I polysaccharide export protein epsB
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focal adhesion kinase 1
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gene lck protein kinase
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gene lck tyrosine kinase
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Hematopoietic consensus tyrosine-lacking kinase
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Hemopoietic cell kinase
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IL-2-inducible T-cell kinase
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Itk
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JAK protein tyrosine kinase
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Kinase EMB
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Kinase EMT
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Kinase TLK
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kinase, protein (phosphorylating tyrosine)
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kinase, protein p56lck (phosphorylating)
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L-JAK
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Lck Tyrosine kinase
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Leukocyte janus kinase
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LSK
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nonreceptor protein tyrosine kinase
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NTK38
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Nuclear tyrosine protein kinase RAK
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ORF6
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p150
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p55-BLK
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P55-FGR
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p56-HCK
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p56-HCK/p59-HCK
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P56-LCK
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p56lck kinase
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p56lck protein kinase
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p56lck protein tyrosine kinase
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p56lck tyrosine kinase
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P57-STK
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P59-FYN
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p59-HCK/p60-HCK
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P60-SRC
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p60-YRK
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P61-YES
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p94-FER
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phosphotyrosyl-protein kinase
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PP125FAK
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Protein kinase (tyrosine-phosphorylating)
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protein kinase A
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Protein kinase BATK
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Protein kinase HYL
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Protein kinase Lck
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Protein kinase NTK
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Protein kinase p56-LCK
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Protein kinase p56lck
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Protein p56c-lck kinase
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Protein p56lck tyrosine kinase
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Protein tyrosine kinase
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protein tyrosine kinase 2beta
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Protein tyrosine kinase lck
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Protein tyrosine kinase p56lck
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Protein tyrosine kinase pp56lck
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Protein-tyrosine kinase C-TKL
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Protein-tyrosine kinase CYL
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PTK
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PTK-RL-18
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PTK70
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Quek1
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Related adhesion focal tyrosine kinase
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Resting lymphocyte kinase
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Rlk/Txk
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S-domain receptor-like protein kinase
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SLK
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Spleen tyrosine kinase
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src-kinase
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SRC-related intestinal kinase
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Syk-related tyrosine kinase
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SYN
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T cell-specific protein-tyrosine kinase
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T-cell-specific kinase
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Tyrosine kinase
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Tyrosine kinase ARG
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Tyrosine kinase lck
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Tyrosine kinase p56lck
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Tyrosine phosphokinase
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Tyrosine protein kinase
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Tyrosine protein kinase p56lck
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Tyrosine-protein kinase brk
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Tyrosine-protein kinase CTK
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Tyrosine-protein kinase Lyk
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Tyrosine-protein kinase TYRO 10
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Tyrosine-specific protein kinase
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Tyrosylprotein kinase
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v-fps Protein-tyrosine kinase
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WEE1hu
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YES related kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
cellular counterpart of the viral v-fms oncogene product, the c-fms product, is the receptor for colony-stimulating factor 1 of macrophages, CSF-1. CSF-1 appeares to activate the serine/threonine kinase
-
additional information
-
cellular counterpart of the viral v-fms oncogene product, the c-fms product, is the receptor for colony-stimulating factor 1 of macrophages, CSF-1. CSF-1 appeares to activate the serine/threonine kinase
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
the presence of hydrophobic signal peptides within the amino-terminal leader sequence and in the middle of the v-fms-encoded moiety suggests that the transforming glycoprotein becomes oriented with its amino terminus within the lumen of the rough endoplasmic reticulum and its carboxyl terminus protruding across the membrane of the rough endoplasmic reticulum into the cytoplasm
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase
additional information
sequence of the transforming polyprotein of the McDonough strain of feline sarcoma virus includes 231 nucleotides specifying a leader peptide, 1,377 nucleotides encoding most of the feline leukemia virus-derived gag gene, and 2,969 nucleotides representing the viral transforming gene v-fms
additional information
-
sequence of the transforming polyprotein of the McDonough strain of feline sarcoma virus includes 231 nucleotides specifying a leader peptide, 1,377 nucleotides encoding most of the feline leukemia virus-derived gag gene, and 2,969 nucleotides representing the viral transforming gene v-fms
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycoprotein
fourteen potential sites for glycosylation are predicted within the v-fms-encoded portion of the protein, primary translation product is rapidly glycosylated
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hampe, A.; Laprevotte, I.; Galibert, F.; Fedele, L.A.; Sherr, C.J.
Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes
Cell
30
775-785
1982
Feline sarcoma virus (P00542), Feline sarcoma virus (P00543), Feline sarcoma virus, Feline sarcoma virus Gardner-Arnstein (P00542), Feline sarcoma virus Snyder-Theilen (P00543)
Hampe, A.; Gobet, M.; Sherr, C.J.; Galibert, F.
Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases
Proc. Natl. Acad. Sci. USA
81
85-89
1984
Feline sarcoma virus (P00545), Feline sarcoma virus, Feline sarcoma virus McDonough (P00545)
Smola, U.; Hennig, D.; Hadwiger-Fangmeier, A.; Schutz, B.; Pfaff, E.; Niemann, H.; Tamura, T.
Reassessment of the v-fms sequence: threonine phosphorylation of the COOH-terminal domain
J. Virol.
65
6181-6187
1991
Feline sarcoma virus (P00545), Feline sarcoma virus
Semba, K.; Kamata, N.; Toyoshima, K.; Yamamoto, T.
A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma
Proc. Natl. Acad. Sci. USA
82
6497-6501
1985
Feline sarcoma virus (P00544), Feline sarcoma virus Gardner-Rasheed (P00544)
Bergold, P.J.; Blumenthal, J.A.; D'Andrea, E.; Snyder, H.W.; Lederman, L.; Silverstone, A.; Nguyen, H.; Besmer, P.
Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert
J. Virol.
61
1193-1202
1987
Feline sarcoma virus (P10447), Feline sarcoma virus, Feline sarcoma virus Hardy-Zuckerman 2 (P10447)
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