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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Fujinami sarcoma virus and UniProt Accession P00530

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EC Tree
IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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This record set is specific for:
Fujinami sarcoma virus
UNIPROT: P00530
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The taxonomic range for the selected organisms is: Fujinami sarcoma virus
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tyrosine-protein kinase transforming protein FPS
-
70 kDa zeta-associated protein
-
-
-
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
-
-
-
-
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LSK
-
-
-
-
nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
-
-
-
-
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
-
-
-
-
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
PTK
-
-
-
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
Tyrosine-protein kinase CTK
-
-
-
-
Tyrosine-protein kinase Lyk
-
-
-
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FPS_FUJSV
873
0
99536
Swiss-Prot
Mitochondrion (Reliability: 4)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E1025D
the mutation causes a complete ts phenotype
H559R
mutation results in a partial temperature sensitivity
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
determination of the entire nucleotide sequence of the molecularly cloned DNA of Fujinami sarcoma virus
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chen, L.H.; Hatada, E.; Wheatley, W.; Lee, W.H.
Single amino acid substitution, from Glu1025 to Asp, of the fps oncogenic protein causes temperature sensitivity in transformation and kinase activity
Virology
155
106-119
1986
Fujinami sarcoma virus (P00530), Fujinami sarcoma virus
Manually annotated by BRENDA team
Shibuya, M.; Hanafusa, H.
Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses
Cell
30
787-795
1982
Fujinami sarcoma virus (P00530)
Manually annotated by BRENDA team