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tyrosine-protein kinase Abl
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70 kDa zeta-associated protein
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Agammaglobulinaemia tyrosine kinase
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Amylovoran biosynthesis membrane-associated protein amsA
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B cell progenitor kinase
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B lymphocyte kinase
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B-cell/myeloid kinase
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BCR-ABL tyrosine kinase
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BMP type II receptor
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BMP-2/BMP-4 receptor
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Bone marrow kinase BMX
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Breast tumor kinase
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Bruton's tyrosine kinase
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Calcium-dependent tyrosine kinase
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Cell adhesion kinase beta
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ectoprotein kinase
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Epithelial and endothelial tyrosine kinase
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EPS I polysaccharide export protein epsB
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focal adhesion kinase 1
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gene lck protein kinase
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gene lck tyrosine kinase
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Hematopoietic consensus tyrosine-lacking kinase
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Hemopoietic cell kinase
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IL-2-inducible T-cell kinase
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JAK protein tyrosine kinase
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kinase, protein (phosphorylating tyrosine)
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kinase, protein p56lck (phosphorylating)
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Lck Tyrosine kinase
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Leukocyte janus kinase
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nonreceptor protein tyrosine kinase
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nonreceptor tyrosine kinase
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Nuclear tyrosine protein kinase RAK
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p56lck protein kinase
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p56lck protein tyrosine kinase
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p56lck tyrosine kinase
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phosphotyrosyl-protein kinase
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Protein kinase (tyrosine-phosphorylating)
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Protein kinase BATK
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Protein kinase HYL
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Protein kinase Lck
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Protein kinase NTK
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Protein kinase p56-LCK
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Protein kinase p56lck
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Protein p56c-lck kinase
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Protein p56lck tyrosine kinase
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Protein tyrosine kinase
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protein tyrosine kinase 2beta
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Protein tyrosine kinase lck
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Protein tyrosine kinase p56lck
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Protein tyrosine kinase pp56lck
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Protein-tyrosine kinase C-TKL
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Protein-tyrosine kinase CYL
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RAF homolog serine/threonine-protein kinase dRAF-1
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Related adhesion focal tyrosine kinase
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Resting lymphocyte kinase
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S-domain receptor-like protein kinase
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serine/threonine-protein kinase receptor TKV
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Spleen tyrosine kinase
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SRC-related intestinal kinase
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Syk-related tyrosine kinase
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T cell-specific protein-tyrosine kinase
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T-cell-specific kinase
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Tyrosine kinase ARG
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Tyrosine kinase lck
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Tyrosine kinase p56lck
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Tyrosine phosphokinase
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Tyrosine protein kinase
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Tyrosine protein kinase p56lck
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Tyrosine-protein kinase brk
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Tyrosine-protein kinase CTK
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tyrosine-protein kinase Fps85D
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tyrosine-protein kinase hopscotch
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Tyrosine-protein kinase Lyk
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tyrosine-protein kinase PR2
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tyrosine-protein kinase shark
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tyrosine-protein kinase Src42A
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tyrosine-protein kinase Src64B
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Tyrosine-protein kinase TYRO 10
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Tyrosine-specific protein kinase
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Tyrosylprotein kinase
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v-fps Protein-tyrosine kinase
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YES related kinase
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additional information
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the enzyme belongs to the Janus family of tyrosine kinases
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ATP + a protein
ADP + a phosphoprotein
enzyme is required in early larval development
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-
?
ATP + cdc2
ADP + phosphorylated cdc2
ATP + signal transducer and activator of transcription
ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription
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-
-
?
ATP + [kinase Btk29]-L-tyrosine
ADP + [kinase Btk29]-L-tyrosine phosphate
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-
-
-
?
ATP + [ring canal protein]-L-tyrosine
ADP + [ring canal protein]-L-tyrosine phosphate
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-
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
additional information
?
-
ATP + cdc2
ADP + phosphorylated cdc2
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-
-
?
ATP + cdc2
ADP + phosphorylated cdc2
the Cdc2-inhibitory kinase is required for preventing premature activation of the mitotic program. Maternally provided Dwee1 is sufficient for regulating Cdc2 during embryogenesis
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-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
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activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview
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?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
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phosphorylation by Jak2 at tyrosine residues
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?
additional information
?
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-
?
additional information
?
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-
?
additional information
?
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mutations in the gene encoding the Drosophila tyrosine kinase Abelson substantially enhanced the severity of the CNS phenotype of armadillo mutations, consistent with these proteins functioning co-operatively at adherens junctions in both the CNS and the epidermis
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?
additional information
?
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in vitro autophosphorylation activity at tyrosine residues
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?
additional information
?
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in vitro autophosphorylation activity at tyrosine residues
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?
additional information
?
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required maternally for the establishment of the normal array of embryonic segments
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?
additional information
?
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plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling
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?
additional information
?
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plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling
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?
additional information
?
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Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview
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?
additional information
?
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receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another
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-
?
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ATP + a protein
ADP + a phosphoprotein
enzyme is required in early larval development
-
-
?
ATP + cdc2
ADP + phosphorylated cdc2
the Cdc2-inhibitory kinase is required for preventing premature activation of the mitotic program. Maternally provided Dwee1 is sufficient for regulating Cdc2 during embryogenesis
-
-
?
ATP + [kinase Btk29]-L-tyrosine
ADP + [kinase Btk29]-L-tyrosine phosphate
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-
-
-
?
ATP + [ring canal protein]-L-tyrosine
ADP + [ring canal protein]-L-tyrosine phosphate
-
-
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
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activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview
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-
?
additional information
?
-
additional information
?
-
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-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
mutations in the gene encoding the Drosophila tyrosine kinase Abelson substantially enhanced the severity of the CNS phenotype of armadillo mutations, consistent with these proteins functioning co-operatively at adherens junctions in both the CNS and the epidermis
-
-
?
additional information
?
-
required maternally for the establishment of the normal array of embryonic segments
-
-
?
additional information
?
-
plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling
-
-
?
additional information
?
-
-
plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling
-
-
?
additional information
?
-
-
Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview
-
-
?
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Danio rerio (O12990), Danio rerio (O93596), Mus musculus (P00520), Mus musculus (Q9R117), Drosophila melanogaster (P00528), Drosophila melanogaster (P18106), Drosophila melanogaster (Q24145), Drosophila melanogaster (Q9V9J3), Homo sapiens (P06239), Homo sapiens (Q06187), Macaca fascicularis (Q95M30), Rattus norvegicus (Q9WUD9)
brenda
Henkemeyer, M.J.; Bennett, R.L.; Gertler, F.B.; Hoffmann, F.M.
DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog
Mol. Cell. Biol.
8
843-853
1988
Drosophila melanogaster (P00522), Drosophila melanogaster
brenda
Hoffmann, F.M.; Fresco, L.D.; Hoffman-Falk, H.; Shilo, B.Z.
Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes
Cell
35
393-401
1983
Drosophila melanogaster (P00522)
brenda
Loureiro, J.; Peifer, M.
Roles of Armadillo, a Drosophila catenin, during central nervous system development
Curr. Biol.
8
622-632
1998
Drosophila melanogaster (P00522)
brenda
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (P54350), Drosophila melanogaster (Q9i7f7)
brenda
Oates, A.C.; Wollberg, P.; Achen, M.G.; Wilks, A.F.
Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA
Biochem. Biophys. Res. Commun.
249
660-667
1998
Drosophila melanogaster (Q9i7f7)
brenda
Sprenger, F.; Trosclair, M.M.; Morrison, D.K.
Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction
Mol. Cell. Biol.
13
1163-1172
1993
Drosophila melanogaster (P11346)
brenda
Ito, M.; Matsui, T.; Taniguchi, T.; Chihara, K.
Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog
Gene
139
215-218
1994
Drosophila melanogaster (Q9i7f7)
brenda
Binari, R.; Perrimon, N.
Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila
Genes Dev.
8
300-312
1994
Drosophila melanogaster (Q24592)
brenda
Fujimoto, J.; Sawamoto, K.; Okabe, M.; Takagi, Y.; Tezuka, T.; Yoshikawa, S.; Ryo, H.; Okano, H.; Yamamoto, T.
Cloning and characterization of Dfak56, a homolog of focal adhesion kinase, in Drosophila melanogaster
J. Biol. Chem.
274
29196-29201
1999
Drosophila melanogaster (Q9U5Y2), Drosophila melanogaster
brenda
Penton, A.; Chen, Y.; Staehling-Hampton, K.; Wrana, J.L.; Attisano, L.; Szidonya, J.; Cassill, J.A.; Massague, J.; Hoffmann, F.M.
Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
Cell
78
239-250
1994
Drosophila melanogaster (Q27933)
brenda
Brummel, T.J.; Twombly, V.; Marques, G.; Wrana, J.L.; Newfeld, S.J.; Attisano, L.; Massague, J.; O'Connor, M.B.; Gelbart, W.M.
Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila
Cell
78
251-261
1994
Drosophila melanogaster (Q27933)
brenda
Mark, G.E.; MacIntyre, R.J.; Digan, M.E.; Ambrosio, L.; Perrimon, N.
Drosophila melanogaster homologs of the raf oncogene
Mol. Cell. Biol.
7
2134-2140
1987
Drosophila melanogaster (P11346)
brenda
Nishida, Y.; Hata, M.; Ayaki, T.; Ryo, H.; Yamagata, M.; Shimizu, K.; Nishizuka, Y.
Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene
EMBO J.
7
775-781
1988
Drosophila melanogaster (P11346)
brenda
Campbell, S.D.; Sprenger, F.; Edgar, B.A.; O'Farrell, P.H.
Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro
Mol. Biol. Cell
6
1333-1347
1995
Drosophila melanogaster (P54350)
brenda
Wallace, T.A.; Sayeski, P.P.
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?
Cell Biochem. Biophys.
44
213-222
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
brenda
Issigonis, M.; Tulina, N.; de Cuevas, M.; Brawley, C.; Sandler, L.; Matunis, E.
JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche
Science
326
153-156
2009
Drosophila melanogaster
brenda
Tsarouhas, V.; Yao, L.; Samakovlis, C.
Src kinases and ERK activate distinct responses to Stitcher receptor tyrosine kinase signaling during wound healing in Drosophila
J. Cell Sci.
127
1829-1839
2014
Drosophila melanogaster
brenda