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EC Tree
IUBMB Comments Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
The taxonomic range for the selected organisms is: Danio rerio The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase,
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tyrosine-protein kinase JAK1
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70 kDa zeta-associated protein
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Agammaglobulinaemia tyrosine kinase
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Amylovoran biosynthesis membrane-associated protein amsA
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B cell progenitor kinase
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B lymphocyte kinase
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B-cell/myeloid kinase
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BCR-ABL tyrosine kinase
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BMP type II receptor
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BMP-2/BMP-4 receptor
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Bone marrow kinase BMX
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Breast tumor kinase
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Bruton's tyrosine kinase
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Calcium-dependent tyrosine kinase
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Cell adhesion kinase beta
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ectoprotein kinase
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Epithelial and endothelial tyrosine kinase
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EPS I polysaccharide export protein epsB
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focal adhesion kinase 1
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gene lck protein kinase
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gene lck tyrosine kinase
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Hematopoietic consensus tyrosine-lacking kinase
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Hemopoietic cell kinase
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IL-2-inducible T-cell kinase
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JAK protein tyrosine kinase
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kinase, protein (phosphorylating tyrosine)
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kinase, protein p56lck (phosphorylating)
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Lck Tyrosine kinase
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Leukocyte janus kinase
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nonreceptor protein tyrosine kinase
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Nuclear tyrosine protein kinase RAK
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p56lck protein kinase
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p56lck protein tyrosine kinase
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p56lck tyrosine kinase
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phosphotyrosyl-protein kinase
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Protein kinase (tyrosine-phosphorylating)
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Protein kinase BATK
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Protein kinase HYL
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Protein kinase Lck
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Protein kinase NTK
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Protein kinase p56-LCK
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Protein kinase p56lck
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Protein p56c-lck kinase
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Protein p56lck tyrosine kinase
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protein tyrosine kinase 2beta
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Protein tyrosine kinase lck
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Protein tyrosine kinase p56lck
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Protein tyrosine kinase pp56lck
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protein-tyrosine kinase
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Protein-tyrosine kinase C-TKL
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Protein-tyrosine kinase CYL
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Related adhesion focal tyrosine kinase
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Resting lymphocyte kinase
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S-domain receptor-like protein kinase
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Spleen tyrosine kinase
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SRC-related intestinal kinase
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Syk-related tyrosine kinase
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T cell-specific protein-tyrosine kinase
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T-cell-specific kinase
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Tyrosine kinase ARG
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Tyrosine kinase lck
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Tyrosine kinase p56lck
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Tyrosine phosphokinase
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Tyrosine protein kinase
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Tyrosine protein kinase p56lck
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Tyrosine-protein kinase brk
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Tyrosine-protein kinase CTK
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Tyrosine-protein kinase Lyk
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Tyrosine-protein kinase TYRO 10
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Tyrosine-specific protein kinase
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Tyrosylprotein kinase
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v-fps Protein-tyrosine kinase
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YES related kinase
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Protein tyrosine kinase
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Protein tyrosine kinase
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PTK
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additional information
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the enzymes belong to the Src family of kinases
additional information
Yes kinase is a Src-family tyrosine kinase
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phospho group transfer
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ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
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114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
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ATP + peptide
ADP + phospho-L-tyrosinyl-peptide
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PTKs phosphorylate substrates in a sequence-specific manner, relatively short peptide sequences determine selectivity, substrate specificity analysis using 144 different peptides, overview
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?
ATP + [FAK]-L-tyrosine
ADP + [FAK]-L-tyrosine phosphate
additional information
?
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ATP + [FAK]-L-tyrosine
ADP + [FAK]-L-tyrosine phosphate
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?
ATP + [FAK]-L-tyrosine
ADP + [FAK]-L-tyrosine phosphate
activation of FAK during epiboly and gastrulation by dynamic phosphorylation at Tyr861
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?
additional information
?
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Yes kinase is required during development, overview
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?
additional information
?
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Yes kinase is required during development, overview
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?
additional information
?
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the Yes kinase performs autophosphorylation
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?
additional information
?
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the Yes kinase performs autophosphorylation
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?
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ATP + [FAK]-L-tyrosine
ADP + [FAK]-L-tyrosine phosphate
activation of FAK during epiboly and gastrulation by dynamic phosphorylation at Tyr861
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?
additional information
?
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additional information
?
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Yes kinase is required during development, overview
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?
additional information
?
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Yes kinase is required during development, overview
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?
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ATP
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Mg2+
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4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine
i.e. pp2, inhibits Src family PTKs, inhibition of zebrafish egg/embryo development by Yes kinase inhibition
4-amino-7-phenylpyrazolo[3,4-d] pyrimidine
i.e. pp3, inhibits Src family PTKs, slight inhibition of zebrafish egg/embryo development by Yes kinase inhibition
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SwissProt
brenda
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brenda
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brenda
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brenda
additional information
enzyme is active at all stages of egg and embryo development
brenda
additional information
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enzyme is active at all stages of egg and embryo development
brenda
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brenda
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JAK1_DANRE
1153
0
132481
Swiss-Prot
other Location (Reliability: 2 )
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62000
x * 62000, recombinant Yes-kinase, SDS-PAGE
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?
x * 62000, recombinant Yes-kinase, SDS-PAGE
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phosphoprotein
the Yes kinase performs autophosphorylation
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additional information
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construction of Fyn/Yes and Wnt11 knockout mutants, activity profiling and phenotype analysis, overview
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recombinant c-Yes GST-fusion U and SH3 domains from Escherichia coli strain DH5alpha by glutathione affinity chromatography
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expression of c-Yes domains U and SH3 as GST-fusion proteins in Escherichia coli strain DH5alpha
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Danio rerio (O12990), Danio rerio (O93596), Mus musculus (P00520), Mus musculus (Q9R117), Drosophila melanogaster (P00528), Drosophila melanogaster (P18106), Drosophila melanogaster (Q24145), Drosophila melanogaster (Q9V9J3), Homo sapiens (P06239), Homo sapiens (Q06187), Macaca fascicularis (Q95M30), Rattus norvegicus (Q9WUD9)
brenda
Tsai, W.B.; Zhang, X.; Sharma, D.; Wu, W.; Kinsey, W.H.
Role of Yes kinase during early zebrafish development
Dev. Biol.
277
129-141
2005
Danio rerio (A1A5H8), Danio rerio
brenda
Lemeer, S.; Jopling, C.; Naji, F.; Ruijtenbeek, R.; Slijper, M.; Heck, A.J.; den Hertog, J.
Protein-tyrosine kinase activity profiling in knock down zebrafish embryos
PLoS ONE
7
581
2007
Danio rerio
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brenda