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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase

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EC Tree
IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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This record set is specific for:
UNIPROT: P23458
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tyrosine-protein kinase JAK1
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70 kDa zeta-associated protein
-
-
-
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ACTR-IIB
-
-
-
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ACTRIIA
-
-
-
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Agammaglobulinaemia tyrosine kinase
-
-
-
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Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
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ATK
-
-
-
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B cell progenitor kinase
-
-
-
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B lymphocyte kinase
-
-
-
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B-cell/myeloid kinase
-
-
-
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BCR-ABL tyrosine kinase
-
-
-
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BMK
-
-
-
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BMP type II receptor
-
-
-
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BMP-2/BMP-4 receptor
-
-
-
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Bone marrow kinase BMX
-
-
-
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BPK
-
-
-
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Breast tumor kinase
-
-
-
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Bruton's tyrosine kinase
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-
-
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c-ABL
-
-
-
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c-FER
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-
-
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C-FES
-
-
-
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C-SRC
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-
-
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C-SRC kinase
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-
-
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C-YES
-
-
-
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CADTK
-
-
-
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CAK beta
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-
-
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Calcium-dependent tyrosine kinase
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-
-
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Cell adhesion kinase beta
-
-
-
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D-ash
-
-
-
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DFer
-
-
-
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Dsrc28C
-
-
-
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ectoprotein kinase
-
-
-
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Epithelial and endothelial tyrosine kinase
-
-
-
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EPS I polysaccharide export protein epsB
-
-
-
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focal adhesion kinase 1
-
-
-
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gene lck protein kinase
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-
-
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gene lck tyrosine kinase
-
-
-
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Hematopoietic consensus tyrosine-lacking kinase
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-
-
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Hemopoietic cell kinase
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-
-
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IL-2-inducible T-cell kinase
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-
-
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Itk
-
-
-
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JAK protein tyrosine kinase
-
-
-
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Kinase EMB
-
-
-
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Kinase EMT
-
-
-
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Kinase TLK
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-
-
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kinase, protein (phosphorylating tyrosine)
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-
-
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kinase, protein p56lck (phosphorylating)
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-
-
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L-JAK
-
-
-
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Lck Tyrosine kinase
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-
-
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Leukocyte janus kinase
-
-
-
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LSK
-
-
-
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nonreceptor protein tyrosine kinase
-
-
-
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NTK38
-
-
-
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Nuclear tyrosine protein kinase RAK
-
-
-
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ORF6
-
-
-
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p150
-
-
-
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p55-BLK
-
-
-
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P55-FGR
-
-
-
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p56-HCK
-
-
-
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p56-HCK/p59-HCK
-
-
-
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P56-LCK
-
-
-
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p56lck kinase
-
-
-
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p56lck protein kinase
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-
-
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p56lck protein tyrosine kinase
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-
-
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p56lck tyrosine kinase
-
-
-
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P57-STK
-
-
-
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P59-FYN
-
-
-
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p59-HCK/p60-HCK
-
-
-
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P60-SRC
-
-
-
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p60-YRK
-
-
-
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P61-YES
-
-
-
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p94-FER
-
-
-
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phosphotyrosyl-protein kinase
-
-
-
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PP125FAK
-
-
-
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Protein kinase (tyrosine-phosphorylating)
-
-
-
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protein kinase A
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-
-
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Protein kinase BATK
-
-
-
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Protein kinase HYL
-
-
-
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Protein kinase Lck
-
-
-
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Protein kinase NTK
-
-
-
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Protein kinase p56-LCK
-
-
-
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Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
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Protein tyrosine kinase
-
-
-
-
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
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Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
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Protein-tyrosine kinase CYL
-
-
-
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PTK
-
-
-
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PTK-RL-18
-
-
-
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PTK70
-
-
-
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Quek1
-
-
-
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Related adhesion focal tyrosine kinase
-
-
-
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Resting lymphocyte kinase
-
-
-
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Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
src-kinase
-
-
-
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SRC-related intestinal kinase
-
-
-
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Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
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T cell-specific protein-tyrosine kinase
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-
-
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T-cell-specific kinase
-
-
-
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Tyrosine kinase
-
-
-
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Tyrosine kinase ARG
-
-
-
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Tyrosine kinase lck
-
-
-
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Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
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Tyrosine protein kinase p56lck
-
-
-
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Tyrosine-protein kinase brk
-
-
-
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Tyrosine-protein kinase CTK
-
-
-
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Tyrosine-protein kinase Lyk
-
-
-
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Tyrosine-protein kinase TYRO 10
-
-
-
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Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
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v-fps Protein-tyrosine kinase
-
-
-
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WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + [Signal Transducer and Activation of Transcription (STAT) protein]-L-tyrosine
ADP + [Signal Transducer and Activation of Transcription (STAT) protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-amino-5-((2R)-3-methylbutan-2-yl)-7-[5-(morpholin-4-yl)-pyridin-2-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
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3-amino-5-((2S)-3-methylbutan-2-yl)-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
3-amino-5-((2S)-3-methylbutan-2-yl)-7-[1-methyl-5-(morpholin-4-yl)-1H-pyrazol-3-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
3-amino-5-((2S)-3-methylbutan-2-yl)-7-[1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-3-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]-pyridin-4-one
-
3-amino-5-((2S)-3-methylbutan-2-yl)-7-[5-(morpholin-4-yl)-pyridin-2-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
3-amino-5-(2-methylpentan-3-yl)-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
3-amino-5-(3-methylbutan-2-yl)-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
3-amino-5-(3-methylbutan-2-yl)-7-[5-(morpholin-4-yl)pyridin-2-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
3-amino-5-isobutyl-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
3-amino-5-sec-butyl-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
3-amino-7-[5-(1,1-dioxidothiomorpholin-4-yl)-1-methyl-1H-pyrazol-3-yl]-5-((2S)-3-methylbutan-2-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
3-amino-7-[5-(2-hydroxypropan-2-yl)-1-methyl-1H-pyrazol-3-yl]-5-((2S)-3-methylbutan-2-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0001
3-amino-5-((2R)-3-methylbutan-2-yl)-7-[5-(morpholin-4-yl)-pyridin-2-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.00003
3-amino-5-((2S)-3-methylbutan-2-yl)-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.000016
3-amino-5-((2S)-3-methylbutan-2-yl)-7-[1-methyl-5-(morpholin-4-yl)-1H-pyrazol-3-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.000024
3-amino-5-((2S)-3-methylbutan-2-yl)-7-[1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-3-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]-pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.0000069
3-amino-5-((2S)-3-methylbutan-2-yl)-7-[5-(morpholin-4-yl)-pyridin-2-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.00026
3-amino-5-(2-methylpentan-3-yl)-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.000079
3-amino-5-(3-methylbutan-2-yl)-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.000015
3-amino-5-(3-methylbutan-2-yl)-7-[5-(morpholin-4-yl)pyridin-2-yl]-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.00023
3-amino-5-isobutyl-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.000091
3-amino-5-sec-butyl-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.000067
3-amino-7-[5-(1,1-dioxidothiomorpholin-4-yl)-1-methyl-1H-pyrazol-3-yl]-5-((2S)-3-methylbutan-2-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.000016
3-amino-7-[5-(2-hydroxypropan-2-yl)-1-methyl-1H-pyrazol-3-yl]-5-((2S)-3-methylbutan-2-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one
Homo sapiens
37°C, pH not specified in the publication
0.00000099
baricitinib
Homo sapiens
37°C, pH not specified in the publication
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
derived from the neural crest
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
JAK1_HUMAN
1154
0
133277
Swiss-Prot
other Location (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lee, S.T.; Strunk, K.M.; Spritz, R.A.
A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes
Oncogene
8
3403-3410
1993
Homo sapiens (P23458), Homo sapiens (Q05397)
Manually annotated by BRENDA team
Wilks, A.F.; Harpur, A.G.; Kurban, R.R.; Ralph, S.J.; Zurcher, G.; Ziemiecki, A.
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
Mol. Cell. Biol.
11
2057-2065
1991
Homo sapiens (P23458)
Manually annotated by BRENDA team
Yogo, T.; Nagamiya, H.; Seto, M.; Sasaki, S.; Shih-Chung, H.; Ohba, Y.; Tokunaga, N.; Lee, G.N.; Rhim, C.Y.; Yoon, C.H.; Cho, S.Y.; Skene, R.; Yamamoto, S.; Satou, Y.; Kuno, M.; Miyazaki, T.; Nakagawa, H.; Okabe, A.; Marui, S.; Aso, K.; Yoshida, M.
Structure-based design and synthesis of 3-amino-1,5-dihydro-4H-pyrazolopyridin-4-one derivatives as tyrosine kinase 2 inhibitors
J. Med. Chem.
59
733-749
2016
Homo sapiens (O60674), Homo sapiens (P23458), Homo sapiens (P29597), Homo sapiens (P52333), Homo sapiens
Manually annotated by BRENDA team