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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Bos taurus and UniProt Accession Q06807

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IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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This record set is specific for:
Bos taurus
UNIPROT: Q06807
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
angiopoietin 1 receptor
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Adhesion-related kinase
-
-
-
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Anaplastic lymphoma kinase
-
-
-
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AXL oncogene
-
-
-
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Brain-specific kinase
-
-
-
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Breathless protein
-
-
-
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c-erbB3
-
-
-
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c-fgr
-
-
-
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c-fms
-
-
-
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c-kit
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-
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c-Kit tyrosine kinase
-
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-
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C-mer
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c-met
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-
-
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C-ret
-
-
-
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C14
-
-
-
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Cadherin 96Ca
-
-
-
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CD115 antigen
-
-
-
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CD117 antigen
-
-
-
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CD135 antigen
-
-
-
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CD136 antigen
-
-
-
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CD140a antigen
-
-
-
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CD140b antigen
-
-
-
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CD167a antigen
-
-
-
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CD202b antigen
-
-
-
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CD220 antigen
-
-
-
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CD221 antigen
-
-
-
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CD246 antigen
-
-
-
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CDW136
-
-
-
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CEK4
-
-
-
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Cell adhesion kinase
-
-
-
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Derailed protein
-
-
-
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DFGF-R1
-
-
-
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Discoidin receptor tyrosine kinase
-
-
-
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Doughnut protein
-
-
-
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Dror
-
-
-
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Drosophila relative of ERBB
-
-
-
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DRT
-
-
-
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EBK
-
-
-
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EGF receptor tyrosine kinase
-
-
-
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Egfr
-
-
-
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EGFr TK
-
-
-
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Egg laying defective protein 15
-
-
-
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ELK
-
-
-
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Embryonic brain kinase
-
-
-
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Endothelial kinase receptor EK1
-
-
-
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EPH-and ELK-related kinase
-
-
-
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Epidermal growth factor receptor-related protein
-
-
-
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Epithelial cell kinase
-
-
-
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erbB tyrosine kinase
-
-
-
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ErbB2 kinase
-
-
-
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ERK
-
-
-
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ETK
-
-
-
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Fms proto-oncogene
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-
-
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GCTK
-
-
-
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GP145-TrkB
-
-
-
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GP145-TrkB/GP95-TrkB
-
-
-
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GP145-TrkC
-
-
-
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Gurken receptor
-
-
-
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Heartless protein
-
-
-
-
HEK
-
-
-
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HEK3
-
-
-
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HEK4
-
-
-
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HEK6
-
-
-
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Heparin-binding growth factor receptor
-
-
-
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HGF receptor
-
-
-
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HGF-SF receptor
-
-
-
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hydroxyaryl-protein kinase
-
-
-
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HYK
-
-
-
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ILP receptor
-
-
-
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insulin receptor protein-tyrosine kinase
-
-
-
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IR-related receptor
-
-
-
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IRK
-
-
-
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IRR
-
-
-
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Keratinocyte growth factor receptor
-
-
-
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Kinase insert domain receptor
-
-
-
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Kinase NYK
-
-
-
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Kinase VIK
-
-
-
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Linotte protein
-
-
-
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mast/stem cell growth factor receptor
-
MEK4
-
-
-
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Met proto-oncogene tyrosine kinase
-
-
-
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Met-related kinase
-
-
-
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MFR
-
-
-
-
MIR
-
-
-
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MLN 19
-
-
-
-
mROR1
-
-
-
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mROR2
-
-
-
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MSP receptor
-
-
-
-
NET
-
-
-
-
NEU proto-oncogene
-
-
-
-
Neurospecific receptor tyrosine kinase
-
-
-
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NRTK
-
-
-
-
NUK
-
-
-
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P140 TEK
-
-
-
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p140-TrkA
-
-
-
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p180erbB4
-
-
-
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p185-Ron
-
-
-
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p185erbB2
-
-
-
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Pagliaccio
-
-
-
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PDGF-R-alpha
-
-
-
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PDGF-R-beta
-
-
-
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PDGFR
-
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PDGFR kinase
-
-
-
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platelet-derived growth factor receptor
-
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Protein-tyrosine kinase byk
-
-
-
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Protein-tyrosine kinase receptor MPK-11
-
-
-
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Proto-oncogene tyrosine-protein kinase Kit
-
-
-
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Receptor protein-tyrosine kinase HEK11
-
-
-
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Receptor protein-tyrosine kinase HEK5
-
-
-
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Receptor protein-tyrosine kinase HEK7
-
-
-
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Receptor protein-tyrosine kinase HEK8
-
-
-
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Receptor protein-tyrosine kinase TKT
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-
-
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Receptor tyrosine kinase MerTK
-
-
-
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Receptor-activated Janus kinase
-
-
-
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Ron
-
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RON receptor tyrosine kinase
-
-
RTK
-
-
-
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SCFR
-
-
-
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Slow nerve growth factor receptor
-
-
-
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Stem cell-derived tyrosine kinase
-
-
-
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Torpedo protein
-
-
-
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TRK1 transforming tyrosine kinase protein
-
-
-
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TrkB tyrosine kinase
-
-
-
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TrkC tyrosine kinase
-
-
-
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Tunica interna endothelial cell kinase
-
-
-
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Tyrosine kinase CEK6 receptor
-
-
-
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Tyrosine kinase DDR
-
-
-
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Tyrosine kinase receptor HD-14
-
-
-
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Tyrosine kinase-type cell surface receptor HER2
-
-
-
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Tyrosine kinase-type cell surface receptor HER3
-
-
-
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Tyrosine kinase-type cell surface receptor HER4
-
-
-
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Tyrosine-protein kinase CAK
-
-
-
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Tyrosine-protein kinase CEK9
-
-
-
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Tyrosine-protein kinase DTK
-
-
-
-
Tyrosine-protein kinase FLT3
-
-
-
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Tyrosine-protein kinase FRT
-
-
-
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Tyrosine-protein kinase receptor CEK10
-
-
-
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Tyrosine-protein kinase receptor CEK11
-
-
-
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Tyrosine-protein kinase receptor CEK5
-
-
-
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Tyrosine-protein kinase receptor CEK7
-
-
-
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Tyrosine-protein kinase receptor CEK8
-
-
-
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Tyrosine-protein kinase receptor CEPHA7
-
-
-
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Tyrosine-protein kinase receptor ECK
-
-
-
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Tyrosine-protein kinase receptor EEK
-
-
-
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Tyrosine-protein kinase receptor EPH
-
-
-
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Tyrosine-protein kinase receptor ESK
-
-
-
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Tyrosine-protein kinase receptor ETK1
-
-
-
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Tyrosine-protein kinase receptor FLT
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-
-
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Tyrosine-protein kinase receptor FLT3
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-
-
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Tyrosine-protein kinase receptor FLT4
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-
-
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Tyrosine-protein kinase receptor HTK
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-
-
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Tyrosine-protein kinase receptor PAG
-
-
-
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Tyrosine-protein kinase receptor QEK5
-
-
-
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Tyrosine-protein kinase receptor REK4
-
-
-
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Tyrosine-protein kinase receptor SEK
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-
-
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Tyrosine-protein kinase receptor TCK
-
-
-
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Tyrosine-protein kinase receptor TEK
-
-
-
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tyrosine-protein kinase receptor Tie-1
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Tyrosine-protein kinase receptor XEK
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-
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Tyrosine-protein kinase receptor XELK
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-
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Tyrosine-protein kinase receptor ZEK1
-
-
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Tyrosine-protein kinase receptor ZEK2
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-
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Tyrosine-protein kinase receptor ZEK3
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-
-
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Tyrosine-protein kinase RSE
-
-
-
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Tyrosine-protein kinase SKY
-
-
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Vascular permeability factor receptor
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ebselen
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expressed in early embryonic vascular system
Manually annotated by BRENDA team
expressed in early embryonic vascular system
Manually annotated by BRENDA team
-
tracheal
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TIE2_BOVIN
1125
1
125927
Swiss-Prot
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
sequence of a bovine c-kit proto-oncogene cDNA
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kubota, T.; Hikono, H.; Sasaki, E.; Sakurai, M.
Sequence of a bovine c-kit proto-oncogene cDNA
Gene
141
305-306
1994
Bos taurus (P43481), Bos taurus
Manually annotated by BRENDA team
Sato, T.N.; Qin, Y.; Kozak, C.A.; Audus, K.L.
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system
Proc. Natl. Acad. Sci. USA
90
9355-9358
1993
Mus musculus (Q02858), Mus musculus (Q06806), Mus musculus, Bos taurus (Q06807)
Manually annotated by BRENDA team
Schnurch, H.; Risau, W.
Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage
Development
119
957-968
1993
Mus musculus (Q02858), Mus musculus, Bos taurus (Q06805)
Manually annotated by BRENDA team
Aslan, M.; Ozben, T.
Oxidants in receptor tyrosine kinase signal transduction pathways
Antioxid. Redox Signal.
5
781-788
2003
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Wagh, P.K.; Peace, B.E.; Waltz, S.E.
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis
Adv. Cancer Res.
100
1-33
2008
Bos taurus, Canis lupus, Gallus gallus, Equus caballus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus, Strongylocentrotus purpuratus, Takifugu rubripes
Manually annotated by BRENDA team