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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Rattus norvegicus and UniProt Accession Q03351

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IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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Select one or more organisms in this record: ?
This record set is specific for:
Rattus norvegicus
UNIPROT: Q03351
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NT-3 growth factor receptor
-
TrkC receptor tyrosine kinase
-
Adhesion-related kinase
-
-
-
-
alpha platelet-derived growth factor receptor
-
Anaplastic lymphoma kinase
-
-
-
-
AXL oncogene
-
-
-
-
basic fibroblast growth factor receptor 1
-
BDNF/NT-3 growth factors receptor
-
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
-
-
-
-
c-kit
c-Kit tyrosine kinase
-
-
-
-
C-mer
-
-
-
-
c-met
C-ret
-
-
-
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
CD115 antigen
-
-
-
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
-
Discoidin receptor tyrosine kinase
-
-
-
-
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
-
DRT
-
-
-
-
EBK
-
-
-
-
EGF receptor tyrosine kinase
EGF-receptor
-
-
EGFr TK
-
-
-
-
EGFR tyrosine kinase
-
-
EGFR-tyrosine kinase
-
-
Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
Embryonic brain kinase
-
-
-
-
Endothelial kinase receptor EK1
-
-
-
-
Eph homologous kinase 3
-
EPH-and ELK-related kinase
-
-
-
-
ephrin type-A receptor 3
-
ephrin type-A receptor 5
-
ephrin type-A receptor 7
-
ephrin type-B receptor 1
-
epidermal growth factor receptor
-
-
epidermal growth factor receptor tyrosine kinase
-
-
Epidermal growth factor receptor-related protein
-
-
-
-
Epithelial cell kinase
-
-
-
-
epithelial discoidin domain receptor 1
-
erbB tyrosine kinase
-
-
-
-
ErbB-4 tyrosine kinase
-
-
ErbB2 kinase
-
-
-
-
erbB2 receptor tyrosine kinase
-
-
ERK
-
-
-
-
ETK
-
-
-
-
Fms proto-oncogene
-
-
-
-
GCTK
-
-
-
-
GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK
-
-
-
-
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
-
hepatocyte growth factor receptor
-
HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
-
high affinity nerve growth factor receptor
-
hydroxyaryl-protein kinase
-
-
-
-
HYK
-
-
-
-
ILP receptor
-
-
-
-
insulin receptor
insulin receptor protein-tyrosine kinase
-
-
-
-
insulin receptor-related receptor
-
insulin-like growth factor I receptor
-
IR-related receptor
-
-
-
-
IRK
-
-
-
-
IRR
-
-
-
-
Keratinocyte growth factor receptor
-
-
-
-
Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
Linotte protein
-
-
-
-
macrophage colony stimulating factor I receptor
-
MEK4
-
-
-
-
Met proto-oncogene tyrosine kinase
-
-
-
-
Met-related kinase
-
-
-
-
MFR
-
-
-
-
MIR
-
-
-
-
MLN 19
-
-
-
-
mROR1
-
-
-
-
mROR2
-
-
-
-
MSP receptor
-
-
-
-
NET
-
-
-
-
NEU proto-oncogene
-
-
-
-
Neurospecific receptor tyrosine kinase
-
-
-
-
neurotrophin tyrosine receptor kinase
-
NRTK
-
-
-
-
NUK
-
-
-
-
P140 TEK
-
-
-
-
p140-TrkA
-
-
-
-
p180erbB4
-
-
-
-
p185-Ron
-
-
-
-
p185erbB2
-
-
-
-
Pagliaccio
-
-
-
-
PDGF receptor
-
-
PDGF receptor tyrosine kinase
-
-
PDGF-R-alpha
-
-
-
-
PDGF-R-beta
-
-
-
-
PDGFR kinase
-
-
-
-
platelet-derived growth factor receptor kinase
-
-
Protein tyrosine kinase
-
-
Protein-tyrosine kinase byk
-
-
-
-
Protein-tyrosine kinase receptor MPK-11
-
-
-
-
Proto-oncogene tyrosine-protein kinase Kit
-
-
-
-
proto-oncogene tyrosine-protein kinase MER
-
rceptor protein-tyrosine kinase erbB-4
-
receptor protein-tyrosine kinase erbB-2
-
receptor protein-tyrosine kinase erbB-3
-
Receptor protein-tyrosine kinase HEK11
-
-
-
-
Receptor protein-tyrosine kinase HEK5
-
-
-
-
Receptor protein-tyrosine kinase HEK7
-
-
-
-
Receptor protein-tyrosine kinase HEK8
-
-
-
-
Receptor protein-tyrosine kinase TKT
-
-
-
-
receptor tyrosine kinase
Receptor tyrosine kinase MerTK
-
-
-
-
receptor tyrosine-protein kinase erbB-2
-
Receptor-activated Janus kinase
-
-
-
-
Ret receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
-
SCFR
-
-
-
-
sky receptor tyrosine kinase
-
Slow nerve growth factor receptor
-
-
-
-
Stem cell-derived tyrosine kinase
-
-
-
-
Torpedo protein
-
-
-
-
TRK1 transforming tyrosine kinase protein
-
-
-
-
TrkB receptor
TrkB tyrosine kinase
-
-
-
-
TrkC tyrosine kinase
-
-
-
-
Tunica interna endothelial cell kinase
-
-
-
-
Tyrosine kinase
-
-
Tyrosine kinase CEK6 receptor
-
-
-
-
Tyrosine kinase DDR
-
-
-
-
tyrosine kinase receptor
-
-
Tyrosine kinase receptor HD-14
-
-
-
-
Tyrosine kinase-type cell surface receptor HER2
-
-
-
-
Tyrosine kinase-type cell surface receptor HER3
-
-
-
-
Tyrosine kinase-type cell surface receptor HER4
-
-
-
-
Tyrosine-protein kinase CAK
-
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
-
Tyrosine-protein kinase DTK
-
-
-
-
Tyrosine-protein kinase FLT3
-
-
-
-
Tyrosine-protein kinase FRT
-
-
-
-
Tyrosine-protein kinase receptor CEK10
-
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
-
Tyrosine-protein kinase receptor CEK5
-
-
-
-
Tyrosine-protein kinase receptor CEK7
-
-
-
-
Tyrosine-protein kinase receptor CEK8
-
-
-
-
Tyrosine-protein kinase receptor CEPHA7
-
-
-
-
Tyrosine-protein kinase receptor ECK
-
-
-
-
Tyrosine-protein kinase receptor EEK
-
-
-
-
Tyrosine-protein kinase receptor EPH
-
-
-
-
Tyrosine-protein kinase receptor ESK
-
-
-
-
Tyrosine-protein kinase receptor ETK1
-
-
-
-
Tyrosine-protein kinase receptor FLT
-
-
-
-
Tyrosine-protein kinase receptor FLT3
-
-
-
-
Tyrosine-protein kinase receptor FLT4
-
-
-
-
Tyrosine-protein kinase receptor HTK
-
-
-
-
Tyrosine-protein kinase receptor PAG
-
-
-
-
Tyrosine-protein kinase receptor QEK5
-
-
-
-
Tyrosine-protein kinase receptor REK4
-
-
-
-
Tyrosine-protein kinase receptor SEK
-
-
-
-
Tyrosine-protein kinase receptor TCK
-
-
-
-
Tyrosine-protein kinase receptor TEK
-
-
-
-
tyrosine-protein kinase receptor TYRO3
-
Tyrosine-protein kinase receptor XEK
-
-
-
-
Tyrosine-protein kinase receptor XELK
-
-
-
-
Tyrosine-protein kinase receptor ZEK1
-
-
-
-
Tyrosine-protein kinase receptor ZEK2
-
-
-
-
Tyrosine-protein kinase receptor ZEK3
-
-
-
-
Tyrosine-protein kinase RSE
-
-
-
-
Tyrosine-protein kinase SKY
-
-
-
-
vascular endothelial growth factor receptor
vascular endothelial growth factor receptor 1
-
vascular endothelial growth factor receptor 2
-
Vascular permeability factor receptor
-
-
-
-
VEGF receptor
-
VEGF-receptor
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + insulin receptor substrate 2-L-tyrosine
ADP + insulin receptor substrate 2-L-tyrosine phosphate
show the reaction diagram
-
-
tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
-
?
ATP + poly-(Glu-Tyr)
ADP + poly-(Glu-Tyr) phosphate
show the reaction diagram
-
-
Tyr-phosphate
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
phospholipase C-gamma 1 is directly phosphorylated by TrkB
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6,7-dimethyl-2-phenylquinoxaline
-
-
AEE788
-
50 mg/kg AEE788 inhibits the autophosphorylation of both epidermal growth factor receptor andvascular endothelial growth factor receptor
AG1296
-
selective inhibitor
AG1478
FPT III
-
inhibition of epidermal growth factor receptor tyrosine kinase
genistein
-
inhibition of epidermal growth factor receptor tyrosine kinase
herceptin
-
-
-
hexachlorobenzene
-
increases after in vivo administration the total epidermal growth factor receptor content and decreases the plasma membrane epidermal growth factor receptor content compared to untreated rats, higher enzyme activity at low doses of 1 mg per kg body weight, reduced enzyme activity at higher doses of 100 mg hexachlorobenzene per kg body weight and above, chronic treatment induces a down-regulation of epidermal growth factor receptor and increases the EGFR-tyrosine kinase activity in the microsomal fraction
imatinib
K-252a
-
complete inhibition at 200 nM
KN93
-
inhibition of epidermal growth factor receptor tyrosine kinase
N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide
shows in vivo inhibition of corneal angiogenesis
PKI-166
-
0.5 mM/kg body weight
ZD1839
-
selective inhibitor
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
dibutyryl cAMP
-
tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
hexachlorobenzene
-
increases after in vivo administration the total epidermal growth factor receptor content and decreases the plasma membrane epidermal growth factor receptor content compared to untreated rats, higher enzyme activity at low doses, reduced enzyme activity at higher doses of hexachlorobenzene
hydrogen peroxide
-
-
protein S
-
-
-
reactive oxygen species
-
additional information
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
areas expressing high levels of trkB or trkC mRNAs included olfactory formations, neocortex, hippocampus, thalamic and hypothalamic nuclei, brainstem nuclei, cerebellum and spinal cord motoneurons
Manually annotated by BRENDA team
expressed during central nervous system neurogenesis
Manually annotated by BRENDA team
hippocampal neurons obtained from 17.5-day-old embryos
Manually annotated by BRENDA team
-
primary cells
Manually annotated by BRENDA team
isoforms are products of abnormal alternative splicing in tumor cell lines
Manually annotated by BRENDA team
isoforms are products of abnormal alternative splicing in tumor cell lines
Manually annotated by BRENDA team
normal peripheral blood mononuclear cell
Manually annotated by BRENDA team
proliferating L6 alpha 1 myoblasts, mrfms gene is transcriptionally active only in undifferentiated myoblasts
Manually annotated by BRENDA team
adult ventricular myocyte
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
nerve growth factor-mediated survival in PC12 cells is associated with surface localized TrkA via the activation of the PI-3K/Akt pathway, whereas internalized TrkA induces nerve growth factor-mediated differentiation via the ERK pathway
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
brain-derived neurotrophic factor and TrkB signaling activates Narp expression alone
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NTRK3_RAT
864
2
97064
Swiss-Prot
Secretory Pathway (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
120000
-
SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
V664E
oncogenic mutation in TM domain, mutation increases the dimerizing propensities of the transmembrane domains
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of the complete coding region of the rat HGF receptor
expressed in cultured NIH-3T3 mouse fibroblasts
expression in HEK 293 and B104-1-1 cells
isolation and sequencing of cDNA clones
isolation of cDNA
the gene for c-fgr is located on chromosome 1
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Rattus norvegicus (O08775), Homo sapiens (P00533), Homo sapiens (P04629), Homo sapiens (P06213), Homo sapiens (P07949), Homo sapiens (P17948), Homo sapiens (Q9UM73), Drosophila melanogaster (P04412), Caenorhabditis elegans (Q10656), Gallus gallus (Q91044), Gallus gallus (Q91987)
Manually annotated by BRENDA team
Li, Y.Y.; McTiernan, C.F.; Feldman, A.M.
IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytes
Am. J. Physiol.
274
H331-341
1998
Rattus norvegicus (O08680)
Manually annotated by BRENDA team
Bargmann, C.I.; Hung, M.C.; Weinberg, R.A.
The neu oncogene encodes an epidermal growth factor receptor-related protein
Nature
319
226-230
1986
Rattus norvegicus (P06494)
Manually annotated by BRENDA team
Gullick, W.J.; Bottomley, A.C.; Lofts, F.J.; Doak, D.G.; Mulvey, D.; Newman, R.; Crumpton, M.J.; Sternberg, M.J.; Campbell, I.D.
Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein
EMBO J.
11
43-48
1992
Rattus norvegicus (P06494)
Manually annotated by BRENDA team
Lai, C.; Lemke, G.
An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system
Neuron
6
691-704
1991
Rattus norvegicus (P06494), Rattus norvegicus (Q62956)
Manually annotated by BRENDA team
Letwin, K.; Yee, S.P.; Pawson, T.
Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody
Oncogene
3
621-627
1988
Rattus norvegicus (P09759)
Manually annotated by BRENDA team
Lhotak, V.; Greer, P.; Letwin, K.; Pawson, T.
Characterization of elk, a brain-specific receptor tyrosine kinase
Mol. Cell. Biol.
11
2496-2502
1991
Rattus norvegicus (P09759)
Manually annotated by BRENDA team
Inoue, K.; Ikawa, S.; Semba, K.; Sukegawa, J.; Yamamoto, T.; Toyoshima, K.
Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9
Oncogene
1
301-304
1987
Rattus norvegicus (P09759), Homo sapiens (Q08345), Homo sapiens
Manually annotated by BRENDA team
Katamine, S.; Notario, V.; Rao, C.D.; Miki, T.; Cheah, M.S.; Tronick, S.R.; Robbins, K.C.
Primary structure of the human fgr proto-oncogene product p55c-fgr
Mol. Cell. Biol.
8
259-266
1988
Rattus norvegicus (P09759)
Manually annotated by BRENDA team
Nishizawa, M.; Semba, K.; Yoshida, M.C.; Yamamoto, T.; Sasaki, M.; Toyoshima, K.
Structure, expression, and chromosomal location of the human c-fgr gene
Mol. Cell. Biol.
6
511-517
1986
Rattus norvegicus (P09759)
Manually annotated by BRENDA team
Goldstein, B.J.; Dudley, A.L.
The rat insulin receptor: primary structure and conservation of tissue-specific alternative messenger RNA splicing
Mol. Endocrinol.
4
235-244
1990
Rattus norvegicus (P15127)
Manually annotated by BRENDA team
Herren, B.; Weyer, K.A.; Rouge, M.; Lotscher, P.; Pech, M.
Conservation in sequence and affinity of human and rodent PDGF ligands and receptors
Biochim. Biophys. Acta
1173
294-302
1993
Rattus norvegicus (P20786)
Manually annotated by BRENDA team
Lee, K.H.; Bowen-Pope, D.F.; Reed, R.R.
Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium
Mol. Cell. Biol.
10
2237-2246
1990
Rattus norvegicus (P20786)
Manually annotated by BRENDA team
Werner, H.; Woloschak, M.; Adamo, M.; Shen-Orr, Z.; Roberts, C.T., Jr.; LeRoith, D.
Developmental regulation of the rat insulin-like growth factor I receptor gene
Proc. Natl. Acad. Sci. USA
86
7451-7455
1989
Rattus norvegicus (P24062)
Manually annotated by BRENDA team
Du, J.; Delafontaine, P.
Inhibition of vascular smooth muscle cell growth through antisense transcription of a rat insulin-like growth factor I receptor cDNA
Circ. Res.
76
963-972
1995
Rattus norvegicus (P24062)
Manually annotated by BRENDA team
Kurachi, H.; Jobo, K.; Ohta, M.; Kawasaki, T.; Itoh, N.
A new member of the insulin receptor family, insulin receptor-related receptor, is expressed preferentially in the kidney
Biochem. Biophys. Res. Commun.
187
934-939
1992
Rattus norvegicus (P24062)
Manually annotated by BRENDA team
Barker, P.A.; Lomen-Hoerth, C.; Gensch, E.M.; Meakin, S.O.; Glass, D.J.; Shooter, E.M.
Tissue-specific alternative splicing generates two isoforms of the trkA receptor
J. Biol. Chem.
268
15150-15157
1993
Rattus norvegicus (P35739)
Manually annotated by BRENDA team
Meakin, S.O.; Suter, U.; Drinkwater, C.C.; Welcher, A.A.; Shooter, E.M.
The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor
Proc. Natl. Acad. Sci. USA
89
2374-2378
1992
Rattus norvegicus (P35739)
Manually annotated by BRENDA team
Yamane, A.; Seetharam, L.; Yamaguchi, S.; Gotoh, N.; Takahashi, T.; Neufeld, G.; Shibuya, M.
A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1)
Oncogene
9
2683-2690
1994
Rattus norvegicus (P53767)
Manually annotated by BRENDA team
Maisonpierre, P.C.; Barrezueta, N.X.; Yancopoulos, G.D.
Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression
Oncogene
8
3277-3288
1993
Rattus norvegicus (P54757)
Manually annotated by BRENDA team
Taylor, V.; Miescher, G.C.; Pfarr, S.; Honegger, P.; Breitschopf, H.; Lassmann, H.; Steck, A.J.
Expression and developmental regulation of Ehk-1, a neuronal Elk-like receptor tyrosine kinase in brain
Neuroscience
63
163-178
1994
Rattus norvegicus (P54757)
Manually annotated by BRENDA team
Valenzuela, D.M.; Rojas, E.; Griffiths, J.A.; Compton, D.L.; Gisser, M.; Ip, N.Y.; Goldfarb, M.; Yancopoulos, G.D.
Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family
Oncogene
10
1573-1580
1995
Rattus norvegicus (P54759)
Manually annotated by BRENDA team
Ohashi, K.; Honda, S.; Ichinomiya, N.; Nakamura, T.; Mizuno, K.
Molecular cloning and in situ localization in the brain of rat sky receptor tyrosine kinase
J. Biochem.
117
1267-1275
1995
Rattus norvegicus (P55146)
Manually annotated by BRENDA team
D'Cruz, P.M.; Yasumura, D.; Weir, J.; Matthes, M.T.; Abderrahim, H.; LaVail, M.M.; Vollrath, D.
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
Hum. Mol. Genet.
9
645-651
2000
Rattus norvegicus (P57097)
Manually annotated by BRENDA team
Liu, Y.; Tolbert, E.M.; Sun, A.M.; Dworkin, L.D.
Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells
Am. J. Physiol.
271
F679-688
1996
Rattus norvegicus (P97523)
Manually annotated by BRENDA team
Pepper, M.S.; Soriano, J.V.; Menoud, P.A.; Sappino, A.P.; Orci, L.; Montesano, R.
Modulation of hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution
Exp. Cell Res.
219
204-210
1995
Rattus norvegicus (P97523)
Manually annotated by BRENDA team
Tsujii, M.; Kawano, S.; Tsuji, S.; Ito, T.; Hayashi, N.; Horimoto, M.; Mita, E.; Nagano, K.; Masuda, E.; et al.
Increased expression of c-met messenger RNA following acute gastric injury in rats
Biochem. Biophys. Res. Commun.
200
536-541
1994
Rattus norvegicus (P97523)
Manually annotated by BRENDA team
Wallenius, V.R.; Rawet, H.; Skrtic, S.; Helou, K.; Qiu, Y.; Levan, G.; Ekberg, S.; Carlsson, B.; Isaksson, O.G.; Nakamura, T.; Jansson, J.O.
Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA
Mamm. Genome
8
661-667
1997
Rattus norvegicus (P97523)
Manually annotated by BRENDA team
Borycki, A.G.; Guillier, M.; Leibovitch, M.P.; Leibovitch, S.A.
Molecular cloning of CSF-1 receptor from rat myoblasts. Sequence analysis and regulation during myogenesis
Growth Factors
6
209-218
1992
Rattus norvegicus (Q00495)
Manually annotated by BRENDA team
Merlio, J.P.; Ernfors, P.; Jaber, M.; Persson, H.
Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system
Neuroscience
51
513-532
1992
Rattus norvegicus (Q03351)
Manually annotated by BRENDA team
Tsoulfas, P.; Soppet, D.; Escandon, E.; Tessarollo, L.; Mendoza-Ramirez, J.L.; Rosenthal, A.; Nikolics, K.; Parada, L.F.
The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells
Neuron
10
975-990
1993
Rattus norvegicus (Q03351)
Manually annotated by BRENDA team
Valenzuela, D.M.; Maisonpierre, P.C.; Glass, D.J.; Rojas, E.; Nunez, L.; Kong, Y.; Gies, D.R.; Stitt, T.N.; Ip, N.Y.; Yancopoulos, G.D.
Alternative forms of rat TrkC with different functional capabilities
Neuron
10
963-974
1993
Rattus norvegicus (Q03351)
Manually annotated by BRENDA team
Yazaki, N.; Fujita, H.; Ohta, M.; Kawasaki, T.; Itoh, N.
The structure and expression of the FGF receptor-1 mRNA isoforms in rat tissues
Biochim. Biophys. Acta
1172
37-42
1993
Rattus norvegicus (Q04589)
Manually annotated by BRENDA team
Carroll, S.L.; Miller, M.L.; Frohnert, P.W.; Kim, S.S.; Corbett, J.A.
Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration
J. Neurosci.
17
1642-1659
1997
Rattus norvegicus (Q62799), Rattus norvegicus (Q62956)
Manually annotated by BRENDA team
Hellyer, N.J.; Kim, H.H.; Greaves, C.H.; Sierke, S.L.; Koland, J.G.
Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein
Gene
165
279-284
1995
Rattus norvegicus (Q62799)
Manually annotated by BRENDA team
Zhao, Y.Y.; Sawyer, D.R.; Baliga, R.R.; Opel, D.J.; Han, X.; Marchionni, M.A.; Kelly, R.A.
Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
J. Biol. Chem.
273
10261-10269
1998
Rattus norvegicus (Q62956)
Manually annotated by BRENDA team
Sanchez, M.P.; Tapley, P.; Saini, S.S.; He, B.; Pulido, D.; Barbacid, M.
Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain
Proc. Natl. Acad. Sci. USA
91
1819-1823
1994
Rattus norvegicus (Q63474)
Manually annotated by BRENDA team
Middlemas, D.S.; Lindberg, R.A.; Hunter, T.
TrkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors
Mol. Cell. Biol.
11
143-153
1991
Rattus norvegicus (Q63604)
Manually annotated by BRENDA team
Middlemas, D.S.; Meisenhelder, J.; Hunter, T.
Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor
J. Biol. Chem.
269
5458-5466
1994
Rattus norvegicus (Q63604)
Manually annotated by BRENDA team
Randi, A.S.; Sancovich, H.A.; Ferramola de Sancovich, A.M.; Loaiza, A.; Kolliker Frers, R.A.; Spinelli, F.; Kleiman de Pisarev, D.L.
Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver
Biochem. Pharmacol.
65
1495-1506
2003
Rattus norvegicus
Manually annotated by BRENDA team
Fang, Y.; Han, S.I.; Mitchell, C.; Gupta, S.; Studer, E.; Grant, S.; Hylemon, P.B.; Dent, P.
Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes
Hepatology
40
961-971
2004
Rattus norvegicus
Manually annotated by BRENDA team
Benter, I.F.; Juggi, J.S.; Khan, I.; Yousif, M.H.M.; Canatan, H.; Akhtar, S.
Signal transduction mechanisms involved in cardiac preconditioning: role of Ras-GTPase, Ca2+/calmodulin-dependent protein kinase II and epidermal growth factor receptor
Mol. Cell. Biochem.
268
175-183
2005
Rattus norvegicus
Manually annotated by BRENDA team
Hupfeld, C.J.; Olefsky, J.M.
Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins
Annu. Rev. Physiol.
69
561-577
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Bernstein, H.G.; Lendeckel, U.; Bertram, I.; Bukowska, A.; Kanakis, D.; Dobrowolny, H.; Stauch, R.; Krell, D.; Mawrin, C.; Budinger, E.; Keilhoff, G.; Bogerts, B.
Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain
Brain Res. Bull.
69
546-559
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Mehdi, M.Z.; Azar, Z.M.; Srivastava, A.K.
Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling
Cell Biochem. Biophys.
47
1-10
2007
Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Ingram, J.L.; Bonner, J.C.
EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases
Curr. Mol. Med.
6
409-421
2006
Rattus norvegicus
Manually annotated by BRENDA team
Hafizi, S.; Dahlbaeck, B.
Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
FEBS J.
273
5231-5244
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Tapinos, N.; Ohnishi, M.; Rambukkana, A.
ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli
Nat. Med.
12
961-966
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Li, L.; Su, Y.; Zhao, C.; Zhao, H.; Liu, G.; Wang, J.; Xu, Q.
The role of Ret receptor tyrosine kinase in dopaminergic neuron development
Neuroscience
142
391-400
2006
Rattus norvegicus
Manually annotated by BRENDA team
Wagh, P.K.; Peace, B.E.; Waltz, S.E.
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis
Adv. Cancer Res.
100
1-33
2008
Bos taurus, Canis lupus, Gallus gallus, Equus caballus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus, Strongylocentrotus purpuratus, Takifugu rubripes
Manually annotated by BRENDA team
Schulte, J.H.; Kuhfittig-Kulle, S.; Klein-Hitpass, L.; Schramm, A.; Biard, D.S.; Pfeiffer, P.; Eggert, A.
Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells
DNA Repair
7
1757-1764
2008
Rattus norvegicus (P35739), Homo sapiens (Q16288), Homo sapiens
Manually annotated by BRENDA team
Harmange, J.C.; Weiss, M.M.; Germain, J.; Polverino, A.J.; Borg, G.; Bready, J.; Chen, D.; Choquette, D.; Coxon, A.; DeMelfi, T.; DiPietro, L.; Doerr, N.; Estrada, J.; Flynn, J.; Graceffa, R.F.; Harriman, S.P.; Kaufman, S.; La, D.S.; Long, A.; Martin, M.W.; Neervannan, S.; Patel, V.F.; Potashman, M.; Regal, K.
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation
J. Med. Chem.
51
1649-1667
2008
Rattus norvegicus (O08775), Mus musculus (P35918), Homo sapiens (P35968), Homo sapiens
Manually annotated by BRENDA team
Romanelli, R.J.; Wood, T.L.
Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses
J. Neurochem.
105
2055-2068
2008
Cricetulus griseus, Homo sapiens, Rattus norvegicus (P35739)
Manually annotated by BRENDA team
Nurmio, M.; Kallio, J.; Toppari, J.; Jahnukainen, K.
Adult reproductive functions after early postnatal inhibition by imatinib of the two receptor tyrosine kinases, c-kit and PDGFR, in the rat testis
Reprod. Toxicol.
25
442-446
2008
Rattus norvegicus
Manually annotated by BRENDA team
Deng, M.; Huang, H.; Jin, H.; Dirsch, O.; Dahmen, U.
The anti-proliferative side effects of AEE788, a tyrosine kinase inhibitor blocking both EGF- and VEGF-receptor, are liver-size-dependent after partial hepatectomy in rats
Invest. New Drugs
29
593-606
2011
Rattus norvegicus
Manually annotated by BRENDA team
Doyle, S.; Pyndiah, S.; De Gois, S.; Erickson, J.D.
Excitation-transcription coupling via calcium/calmodulin-dependent protein kinase/ERK1/2 signaling mediates the coordinate induction of VGLUT2 and Narp triggered by a prolonged increase in glutamatergic synaptic activity
J. Biol. Chem.
285
14366-14376
2010
Rattus norvegicus
Manually annotated by BRENDA team
Amos, P.J.; Kapur, S.K.; Stapor, P.C.; Shang, H.; Bekiranov, S.; Khurgel, M.; Rodeheaver, G.T.; Peirce, S.M.; Katz, A.J.
Human adipose-derived stromal cells accelerate diabetic wound healing: impact of cell formulation and delivery
Tissue Eng. Part A
16
1595-1606
2010
Rattus norvegicus
Manually annotated by BRENDA team
Fukushima, T.; Arai, T.; Ariga-Nedachi, M.; Okajima, H.; Ooi, Y.; Iijima, Y.; Sone, M.; Cho, Y.; Ando, Y.; Kasahara, K.; Ozoe, A.; Yoshihara, H.; Chida, K.; Okada, S.; Kopchick, J.; Asano, T.; Hakuno, F.; Takahashi, S.
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases
Biochem. Biophys. Res. Commun.
404
767-773
2011
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
He, L.; Shobnam, N.; Hristova, K.
Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domain
Biochim. Biophys. Acta
1808
253-259
2011
Rattus norvegicus (P06494), Homo sapiens (P22607)
Manually annotated by BRENDA team