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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Danio rerio and UniProt Accession O13146

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IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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This record set is specific for:
Danio rerio
UNIPROT: O13146
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The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Eph-like kinase1
-
ephrin type-A receptor 3
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Adhesion-related kinase
-
-
-
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Anaplastic lymphoma kinase
-
-
-
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angiopoietin 1 receptor
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AXL oncogene
-
-
-
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Brain-specific kinase
-
-
-
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Breathless protein
-
-
-
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c-erbB3
-
-
-
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c-fgr
-
-
-
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c-fms
-
-
-
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c-kit
-
-
-
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c-Kit tyrosine kinase
-
-
-
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C-mer
-
-
-
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c-met
-
-
-
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C-ret
-
-
-
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C14
-
-
-
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Cadherin 96Ca
-
-
-
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CD115 antigen
-
-
-
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CD117 antigen
-
-
-
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CD135 antigen
-
-
-
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CD136 antigen
-
-
-
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CD140a antigen
-
-
-
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CD140b antigen
-
-
-
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CD167a antigen
-
-
-
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CD202b antigen
-
-
-
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CD220 antigen
-
-
-
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CD221 antigen
-
-
-
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CD246 antigen
-
-
-
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CDW136
-
-
-
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CEK4
-
-
-
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Cell adhesion kinase
-
-
-
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Derailed protein
-
-
-
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DFGF-R1
-
-
-
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Discoidin receptor tyrosine kinase
-
-
-
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Doughnut protein
-
-
-
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Dror
-
-
-
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Drosophila relative of ERBB
-
-
-
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DRT
-
-
-
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EBK
-
-
-
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EGF receptor tyrosine kinase
-
-
-
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Egfr
-
-
-
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EGFr TK
-
-
-
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Egg laying defective protein 15
-
-
-
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ELK
-
-
-
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Embryonic brain kinase
-
-
-
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Endothelial kinase receptor EK1
-
-
-
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EPH-and ELK-related kinase
-
-
-
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Epidermal growth factor receptor-related protein
-
-
-
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Epithelial cell kinase
-
-
-
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erbB tyrosine kinase
-
-
-
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ErbB2 kinase
-
-
-
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ERK
-
-
-
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ETK
-
-
-
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Fms proto-oncogene
-
-
-
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GCTK
-
-
-
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GP145-TrkB
-
-
-
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GP145-TrkB/GP95-TrkB
-
-
-
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GP145-TrkC
-
-
-
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Gurken receptor
-
-
-
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Heartless protein
-
-
-
-
HEK
-
-
-
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HEK3
-
-
-
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HEK4
-
-
-
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HEK6
-
-
-
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Heparin-binding growth factor receptor
-
-
-
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HGF receptor
-
-
-
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HGF-SF receptor
-
-
-
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hydroxyaryl-protein kinase
-
-
-
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HYK
-
-
-
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ILP receptor
-
-
-
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insulin receptor protein-tyrosine kinase
-
-
-
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IR-related receptor
-
-
-
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IRK
-
-
-
-
IRR
-
-
-
-
Keratinocyte growth factor receptor
-
-
-
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Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
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Kinase VIK
-
-
-
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Linotte protein
-
-
-
-
MEK4
-
-
-
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Met proto-oncogene tyrosine kinase
-
-
-
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Met-related kinase
-
-
-
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MFR
-
-
-
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MIR
-
-
-
-
MLN 19
-
-
-
-
mROR1
-
-
-
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mROR2
-
-
-
-
MSP receptor
-
-
-
-
NET
-
-
-
-
NEU proto-oncogene
-
-
-
-
Neurospecific receptor tyrosine kinase
-
-
-
-
NRTK
-
-
-
-
NUK
-
-
-
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P140 TEK
-
-
-
-
p140-TrkA
-
-
-
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p180erbB4
-
-
-
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p185-Ron
-
-
-
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p185erbB2
-
-
-
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Pagliaccio
-
-
-
-
PDGF-R-alpha
-
-
-
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PDGF-R-beta
-
-
-
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PDGFR kinase
-
-
-
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Protein-tyrosine kinase byk
-
-
-
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Protein-tyrosine kinase receptor MPK-11
-
-
-
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Proto-oncogene tyrosine-protein kinase Kit
-
-
-
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Receptor protein-tyrosine kinase HEK11
-
-
-
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Receptor protein-tyrosine kinase HEK5
-
-
-
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Receptor protein-tyrosine kinase HEK7
-
-
-
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Receptor protein-tyrosine kinase HEK8
-
-
-
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Receptor protein-tyrosine kinase TKT
-
-
-
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Receptor tyrosine kinase MerTK
-
-
-
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Receptor-activated Janus kinase
-
-
-
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RTK
-
-
-
-
SCFR
-
-
-
-
Slow nerve growth factor receptor
-
-
-
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Stem cell-derived tyrosine kinase
-
-
-
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Torpedo protein
-
-
-
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TRK1 transforming tyrosine kinase protein
-
-
-
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TrkB tyrosine kinase
-
-
-
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TrkC tyrosine kinase
-
-
-
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Tunica interna endothelial cell kinase
-
-
-
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Tyrosine kinase CEK6 receptor
-
-
-
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Tyrosine kinase DDR
-
-
-
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Tyrosine kinase receptor HD-14
-
-
-
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Tyrosine kinase-type cell surface receptor HER2
-
-
-
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Tyrosine kinase-type cell surface receptor HER3
-
-
-
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Tyrosine kinase-type cell surface receptor HER4
-
-
-
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Tyrosine-protein kinase CAK
-
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
-
Tyrosine-protein kinase DTK
-
-
-
-
Tyrosine-protein kinase FLT3
-
-
-
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Tyrosine-protein kinase FRT
-
-
-
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Tyrosine-protein kinase receptor CEK10
-
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
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Tyrosine-protein kinase receptor CEK5
-
-
-
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Tyrosine-protein kinase receptor CEK7
-
-
-
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Tyrosine-protein kinase receptor CEK8
-
-
-
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Tyrosine-protein kinase receptor CEPHA7
-
-
-
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Tyrosine-protein kinase receptor ECK
-
-
-
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Tyrosine-protein kinase receptor EEK
-
-
-
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Tyrosine-protein kinase receptor EPH
-
-
-
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Tyrosine-protein kinase receptor ESK
-
-
-
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Tyrosine-protein kinase receptor ETK1
-
-
-
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Tyrosine-protein kinase receptor FLT
-
-
-
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Tyrosine-protein kinase receptor FLT3
-
-
-
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Tyrosine-protein kinase receptor FLT4
-
-
-
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Tyrosine-protein kinase receptor HTK
-
-
-
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Tyrosine-protein kinase receptor PAG
-
-
-
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Tyrosine-protein kinase receptor QEK5
-
-
-
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Tyrosine-protein kinase receptor REK4
-
-
-
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Tyrosine-protein kinase receptor SEK
-
-
-
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Tyrosine-protein kinase receptor TCK
-
-
-
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Tyrosine-protein kinase receptor TEK
-
-
-
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Tyrosine-protein kinase receptor XEK
-
-
-
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Tyrosine-protein kinase receptor XELK
-
-
-
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Tyrosine-protein kinase receptor ZEK1
-
-
-
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Tyrosine-protein kinase receptor ZEK2
-
-
-
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Tyrosine-protein kinase receptor ZEK3
-
-
-
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Tyrosine-protein kinase RSE
-
-
-
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Tyrosine-protein kinase SKY
-
-
-
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vascular endothelial growth factor receptor 2
-
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Vascular permeability factor receptor
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-
-
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VEGFR2
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
VEGFR1 and VEGFR2 are the most important receptors involved in neovascularization
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
EPHA3_DANRE
981
1
109655
Swiss-Prot
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
0.1 mM trans-3,5,4'-trimethoxystilbene downregulates VEGFR2 mRNA expression 4fold
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bovenkamp, D.E.; Greer, P.
Novel Eph-family receptor tyrosine kinase is widely expressed in the developing zebrafish nervous system
Dev. Dyn.
209
166-181
1997
Danio rerio (O13146), Danio rerio
Manually annotated by BRENDA team
Lyons, M.S.; Bell, B.; Stainier, D.; Peters, K.G.
Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-specific receptor tyrosine kinases
Dev. Dyn.
212
133-140
1998
Danio rerio (O73791), Danio rerio
Manually annotated by BRENDA team
Alex, D.; Leong, E.C.; Zhang, Z.J.; Yan, G.T.; Cheng, S.H.; Leong, C.W.; Li, Z.H.; Lam, K.H.; Chan, S.W.; Lee, S.M.
Resveratrol derivative, trans-3,5,4-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation
J. Cell. Biochem.
109
339-346
2010
Danio rerio
Manually annotated by BRENDA team