Information on EC 2.7.1.93 - alkylglycerol kinase

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The expected taxonomic range for this enzyme is: Oryctolagus cuniculus

EC NUMBER
COMMENTARY
2.7.1.93
-
RECOMMENDED NAME
GeneOntology No.
alkylglycerol kinase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Ether lipid metabolism
-
SYSTEMATIC NAME
IUBMB Comments
ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
1-alkylglycerol kinase (phosphorylating)
-
-
-
-
alkylglycerol phosphotransferase
-
-
-
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ATP-alkylglycerol phosphotransferase
-
-
-
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ATP:1-alkyl-sn-glycerol phosphotransferase
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-
-
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kinase, 1-alkylglycerol (phosphorylating)
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-
-
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CAS REGISTRY NUMBER
COMMENTARY
55354-37-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
adult male New Zealand white rabbit
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-alkyl-sn-glycerol
ADP + 1-alkyl-sn-glycero-3-phosphate
show the reaction diagram
-
stereospecific for the substrates possessing an sn-1 alkyl chain
formation of 1-alkyl-2-lyso-sn-glycero-3-phosphate
?
ATP + 1-alkyl-sn-glycerol
ADP + 1-alkyl-sn-glycero-3-phosphate
show the reaction diagram
-
stereoselective transfer of the terminal phosphate of ATP to position 3 of the substrate, ATP is an absolute requirement for enzymatic activity, involved in the biosynthesis of complex ether-linked glycerolipids
-
?
ATP + 1-O-hexadecyl-sn-glycerol
ADP + 1-O-hexadecyl-sn-glycero-3-phosphate
show the reaction diagram
-
-
-
?
ATP + 1-O-hexadecyl-sn-glycerol
ADP + 1-O-hexadecyl-sn-glycero-3-phosphate
show the reaction diagram
-
-
-
?
ATP + 1-octadecyl-sn-glycerol
ADP + 1-octadecyl-sn-glycero-3-phosphate
show the reaction diagram
-
-
-
?
ATP + 1-octadecyl-sn-glycerol
ADP + 1-octadecyl-sn-glycero-3-phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
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not: 3-alkyl-sn-glycerols
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-
-
additional information
?
-
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not: alkylethylene glycols, only trace activity with 1-thio-hexadecyl-2,3-propanediol
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-
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additional information
?
-
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not: S-alkyl-alkylglycerols, 2-hexadecylglycerol, 3-hexadecyl-sn-glycerol, 1-hexadecylethylene glycol
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-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-alkyl-sn-glycerol
ADP + 1-alkyl-sn-glycero-3-phosphate
show the reaction diagram
-
involved in the biosynthesis of complex ether-linked glycerolipids
-
?
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Mg2+
-
absolute requirement for a divalent metal ion, Mg2+ is most effective
Mn2+
-
about 50% as effective as Mg2+ in activation
additional information
-
little activity with Zn2+, Ba2+, Cu2+, Ca2+, Hg2+, Sn2+, Sr2+, Ni2+, Fe2+, NaCl and KCl
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
additional information
-
not inhibited by rac-1-hexadecanoylglycerol, rac-1,2-dihexadecanoylglycerol, rac-1-hexadecyl-2-hexadecanoylglycerol or 2-hexadecylglycerol
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KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.1
-
-
0.1 M Tris-maleate buffer; no sharp pH optimum
7.1
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no sharp pH optimum
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.1
8.1
-
about 66% of maximal activity at pH 6.1 and 8.1
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20°C, whole microsomal preparation, 0.25 M sucrose, 5 mM dithiothreitol, at least 2 months, stable
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-20°C, whole microsomal preparation, at least 2 months, stable
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Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
nutrition
-
enzyme plays a very important role in nutritional experiments, both in vivo and in cell culture, where the intent is either to restore or to increase the cellular levels of ether-linked phospholipids