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Information on EC 2.7.1.91 - sphingosine kinase
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2.7.1.91 sphingosine kinaseIUBMB Comments
The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species.
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Word Map
- 2.7.1.91
- sphingosine-1-phosphate
- 1-phosphate
- sphingolipids
- ceramide
- endothelial
- sirnas
- necrosis
- agonist
- metastasis
- artery
- erk
- phospholipase
- fingolimod
- fibrosis
- lymphocyte
-
protein-coupled
- sphingomyelinase
- tnf
- pulmonary
- leukemia
- sphingomyelin
-
anti-apoptotic
-
s1p-induced
- stat3
- pertussis
- mapks
-
pro-apoptotic
-
mitogen
- sclerosis
- pkc
-
rheostat
-
signal-regulated
- caspase-3
-
pro-survival
-
platelet-derived
- lysophospholipids
-
cardioprotective
- phytosphingosine
- drug development
- lymphopenia
-
egress
- glucosylceramide
- medicine
- fumonisins
-
s1p-mediated
- dihydroceramide
-
mitogenesis
-
pdgf-induced
-
ceramide-induced
-
lysophosphatidic
- fcepsilonri
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
sphk1, sphingosine kinase, sphk2, sphingosine kinase 1, sphingosine kinase-1, sphingosine kinase 2, sphk-1, sphingosine kinase-2, sphk1a, sphingosine kinase type 1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dihydrosphingosine kinase
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kinase, dihydrosphingosine (phosphorylating)
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-
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kinase, sphingosine (phosphorylating)
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SK
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sphingoid base kinase
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SPHK
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP:sphingoid base 1-phosphotransferase
The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species.
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CAS REGISTRY NUMBER
COMMENTARY
50864-48-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
N,N-dimethylsphingosine
0.005 mM, activation to 106% of control
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aberrant Crypt Foci
Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
Abortion, Spontaneous
Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice.
Acquired Immunodeficiency Syndrome
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.
Acute Lung Injury
Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition.
Acute Lung Injury
CALCIUM ENTRY INHIBITION DURING RESUSCITATION FROM SHOCK ATTENUATES INFLAMMATORY LUNG INJURY.
Acute Lung Injury
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.
Adenocarcinoma
Dimethylsphingosine and miltefosine induce apoptosis in lung adenocarcinoma A549?cells in a synergistic manner.
Adenocarcinoma
Down regulation of lncRNA MEG3 promotes colorectal adenocarcinoma cell proliferation and inhibits the apoptosis by up-regulating TGF-?1 and its downstream sphingosine kinase 1.
Adenocarcinoma
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Adenocarcinoma
Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXR? by K48/K63-linked polyubiquitination.
Adenocarcinoma
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells.
Adenocarcinoma
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models.
Adenocarcinoma of Lung
Sphingosine-1-Phosphate Contributes to TLR9-Induced TNF-? Release in Lung Tumor Cells.
Adenoma
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
Adenoma
Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression.
Adrenocortical Carcinoma
Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression.
Albuminuria
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Alveolar Bone Loss
Periodontal inflammation and alveolar bone loss induced by Aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice.
Alzheimer Disease
Effects of small interfering RNA targeting sphingosine kinase-1 gene on the animal model of Alzheimer's disease.
Alzheimer Disease
Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain.
Alzheimer Disease
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Alzheimer Disease
Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease.
Alzheimer Disease
Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival.
Amyotrophic Lateral Sclerosis
Autophagy and ALS: mechanistic insights and therapeutic implications.
Anaphylaxis
Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.
Anaphylaxis
Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo.
Anaphylaxis
The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis.
Anemia
Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.
Anemia
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Anemia, Sickle Cell
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.
Anemia, Sickle Cell
Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity.
Ankylosis
The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes.
Arteriosclerosis
The reduction of allograft arteriosclerosis in intestinal transplant is associated with sphingosine kinase 1/sphingosine-1-phosphate signaling after fish oil treatment.
Arthritis
Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis.
Arthritis
Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.
Arthritis
Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis.
Arthritis
Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.
Arthritis
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
Arthritis
Impact of Sphingosine Kinase on Inflammatory Pathways in Fibroblast-Like Synoviocytes.
Arthritis
Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?
Arthritis
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice.
Arthritis
Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis.
Arthritis
Sphingosine kinase 1/sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 pathway: A novel target of geniposide to inhibit angiogenesis.
Arthritis, Experimental
Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis.
Arthritis, Experimental
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice.
Arthritis, Experimental
S1P Increases VEGF Production in Osteoblasts and Facilitates Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-16-5p Expression via the c-Src/FAK Signaling Pathway in Rheumatoid Arthritis.
Arthritis, Experimental
The interplay between fibroblast-like synovial and vascular endothelial cells leads to angiogenesis via the sphingosine-1-phosphate-induced RhoA-F-Actin and Ras-Erk1/2 pathways and the intervention of geniposide.
Arthritis, Rheumatoid
Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines.
Arthritis, Rheumatoid
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Arthritis, Rheumatoid
Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis.
Arthritis, Rheumatoid
Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720.
Arthritis, Rheumatoid
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Arthritis, Rheumatoid
Impact of Sphingosine Kinase on Inflammatory Pathways in Fibroblast-Like Synoviocytes.
Arthritis, Rheumatoid
Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?
Arthritis, Rheumatoid
Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis.
Arthritis, Rheumatoid
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
Arthritis, Rheumatoid
Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro.
Arthritis, Rheumatoid
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice.
Arthritis, Rheumatoid
Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells.
Arthritis, Rheumatoid
Sphingosine-1-Phosphate Promotes the Persistence of Activated CD4 T Cells in Inflamed Sites.
Asthma
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.
Asthma
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Asthma
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
Asthma
Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.
Asthma
Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models.
Asthma
SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice.
Astrocytoma
Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival.
Astrocytoma
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines.
Atherosclerosis
Elevating Endogenous Sphingosine-1-Phosphate (S1P) Levels Improves Endothelial Function and Ameliorates Atherosclerosis in Low Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice.
Atherosclerosis
High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL.
Atherosclerosis
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
Atherosclerosis
SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet.
Atherosclerosis
Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells.
Atherosclerosis
Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation.
Autoimmune Diseases
Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis.
Bone Resorption
Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts.
Brain Edema
Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice.
Brain Edema
Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage.
Brain Injuries
Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice.
Brain Injuries
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Brain Injuries
Isoflurane cerebral preconditioning in a spontaneous hypertension rat model is associated with sphingosine kinases.
Brain Injuries
Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage.
Brain Injuries
Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke.
Brain Injuries
Post-injury administration of allicin attenuates ischemic brain injury through sphingosine kinase 2: In vivo and in vitro studies.
Brain Ischemia
Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.
Brain Ischemia
Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke.
Brain Ischemia
Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia.
Brain Ischemia
Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival.
Brain Ischemia
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-?B pathways in activated microglia in cerebral ischemia reperfusion.
Brain Neoplasms
Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells.
Breast Neoplasms
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
Breast Neoplasms
A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells.
Breast Neoplasms
A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.
Breast Neoplasms
ABCC1-exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1 Shortens Survival of Mice and Patients with Breast Cancer.
Breast Neoplasms
An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines.
Breast Neoplasms
Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.
Breast Neoplasms
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.
Breast Neoplasms
Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis.
Breast Neoplasms
C16?ceramide and sphingosine 1?phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation.
Breast Neoplasms
Correlation Between Doppler Ultrasound Blood Flow Parameters and Angiogenesis and Proliferation Activity in Breast Cancer.
Breast Neoplasms
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Breast Neoplasms
Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid.
Breast Neoplasms
Divergence of Intracellular Trafficking of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 3 in MCF-7 Breast Cancer Cells and MCF-7-Derived Stem Cell-Enriched Mammospheres.
Breast Neoplasms
Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation.
Breast Neoplasms
Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.
Breast Neoplasms
Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance.
Breast Neoplasms
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.
Breast Neoplasms
Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1.
Breast Neoplasms
Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming.
Breast Neoplasms
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor negative breast cancer.
Breast Neoplasms
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.
Breast Neoplasms
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation and actin rearrangement in MCF-7 breast cancer cells.
Breast Neoplasms
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Breast Neoplasms
Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model.
Breast Neoplasms
Genome-wide DNA methylation assessment of 'BRCA1-like' early-onset breast cancer: Data from the Australian Breast Cancer Family Registry.
Breast Neoplasms
High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients.
Breast Neoplasms
High Expression of Sphingosine Kinase 1 in Estrogen and Progesterone Receptors-Negative Breast Cancer.
Breast Neoplasms
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Breast Neoplasms
Identification of copy number alterations associated with the progression of DCIS to invasive ductal carcinoma.
Breast Neoplasms
Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.
Breast Neoplasms
Identifying novel sphingosine kinase 1 inhibitors as therapeutics against breast cancer.
Breast Neoplasms
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
Breast Neoplasms
Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer.
Breast Neoplasms
Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin.
Breast Neoplasms
Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway.
Breast Neoplasms
Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer.
Breast Neoplasms
Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival.
Breast Neoplasms
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
Breast Neoplasms
Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer.
Breast Neoplasms
Pharmacological Inhibition of Sphingosine Kinase Isoforms Alters Estrogen Receptor Signaling in Human Breast Cancer.
Breast Neoplasms
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.
Breast Neoplasms
Predictive value of sphingosine kinase 1 expression in neoadjuvant treatment of breast cancer.
Breast Neoplasms
Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration.
Breast Neoplasms
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate.
Breast Neoplasms
Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway.
Breast Neoplasms
Resveratrol Dimers Are Novel Sphingosine Kinase 1 Inhibitors and Affect Sphingosine Kinase 1 Expression and Cancer Cell Growth and Survival.
Breast Neoplasms
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor.
Breast Neoplasms
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.
Breast Neoplasms
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Breast Neoplasms
Sphingosine 1-phosphate signaling induces SNAI2 expression to promote cell invasion in breast cancer cells.
Breast Neoplasms
Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action.
Breast Neoplasms
Sphingosine kinase 1 activation by estrogen receptor ?36 contributes to tamoxifen resistance in breast cancer.
Breast Neoplasms
Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer.
Breast Neoplasms
Sphingosine Kinase 1 in Breast Cancer-A New Molecular Marker and a Therapy Target.
Breast Neoplasms
Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells.
Breast Neoplasms
Sphingosine Kinase 1 is Associated With Immune Cell-Related Gene Expressions in Human Breast Cancer.
Breast Neoplasms
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.
Breast Neoplasms
Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1.
Breast Neoplasms
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.
Breast Neoplasms
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
Breast Neoplasms
Sphingosine kinase transmits estrogen signaling in human breast cancer cells.
Breast Neoplasms
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.
Breast Neoplasms
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Breast Neoplasms
Sphingosine-1-phosphate receptor 1 transmits estrogens' effects in endothelial cells.
Breast Neoplasms
Sphk1 participates in malignant progression of breast cancer by regulating epithelial-mesenchymal transition and stem cell characteristics.
Breast Neoplasms
SPHK1 regulates proliferation and survival responses in triple-negative breast cancer.
Breast Neoplasms
Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
Breast Neoplasms
Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.
Breast Neoplasms
TGF?-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis.
Breast Neoplasms
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.
Breast Neoplasms
The Importance of Sphingosine Kinase in Breast Cancer: A Potential for Breast Cancer Management.
Breast Neoplasms
The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ER? expression and enhances hormonal therapy for breast cancer.
Breast Neoplasms
The roles of antiapoptotic sphingosine kinase-1 and glucosylceramide genes in drug induced cell death of MCF-7 breast cancer cells.
Breast Neoplasms
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
Breast Neoplasms
[TNF-? regulates the proliferation of human breast cancer cells via regulation of ceramide content].
Bronchopulmonary Dysplasia
Hyperoxia-induced S1P1 signaling reduced angiogenesis by suppression of TIE-2 leading to experimental bronchopulmonary dysplasia.
Bronchopulmonary Dysplasia
Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia.
Bronchopulmonary Dysplasia
Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model: Role of S1P Signaling and Nox Proteins.
Carcinogenesis
A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells.
Carcinogenesis
Coumestrol suppresses hypoxia inducible factor 1? by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells.
Carcinogenesis
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Carcinogenesis
Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation.
Carcinogenesis
Functional Genetic Variants in SPHK1 Affect Susceptibility to Gastric Cancer in a Chinese Population.
Carcinogenesis
Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model.
Carcinogenesis
Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis.
Carcinogenesis
Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer.
Carcinogenesis
Lentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma.
Carcinogenesis
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.
Carcinogenesis
New insights into the roles and regulation of SphK2 as a therapeutic target in cancer chemoresistance.
Carcinogenesis
NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells.
Carcinogenesis
Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects.
Carcinogenesis
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling.
Carcinogenesis
Prognostic role of lipid phosphate phosphatases in non-smoker, lung adenocarcinoma patients.
Carcinogenesis
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
Carcinogenesis
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.
Carcinogenesis
Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
Carcinogenesis
Sphingosine kinase 1 is required for TGF-? mediated fibroblastto- myofibroblast differentiation in ovarian cancer.
Carcinogenesis
Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1? inactivation in hypoxic PC-3 prostate cancer cells.
Carcinogenesis
Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.
Carcinogenesis
Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.
Carcinogenesis
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.
Carcinogenesis
Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again.
Carcinogenesis
Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
Carcinogenesis
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats.
Carcinogenesis
Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.
Carcinogenesis
The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?
Carcinoma
A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
Carcinoma
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
Carcinoma
An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma.
Carcinoma
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
Carcinoma
Correction: Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis.
Carcinoma
Enhancement of SPHK1 in vitro by carbon ion irradiation in oral squamous cell carcinoma.
Carcinoma
Expression of sphingosine kinase gene in the interactions between human gastric carcinoma cell and vascular endothelial cell.
Carcinoma
Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma.
Carcinoma
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Carcinoma
Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.
Carcinoma
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
Carcinoma
Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin.
Carcinoma
KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2.
Carcinoma
LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR?378a?5p to enhance SPHK1 expression.
Carcinoma
LOSS OF SPHINGOSINE KINASE-1 IN CARCINOMA CELLS INCREASES FORMATION OF REACTIVE OXYGEN SPECIES AND SENSITIVITY TO DOXORUBICIN-INDUCED DNA DAMAGE.
Carcinoma
Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies.
Carcinoma
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
Carcinoma
MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.
Carcinoma
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
Carcinoma
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy.
Carcinoma
Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis.
Carcinoma
Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression.
Carcinoma
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
Carcinoma
Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma.
Carcinoma
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression.
Carcinoma
Sphingosine Kinase-1 Activation Causes Acquired Resistance Against Sunitinib in Renal Cell Carcinoma Cells.
Carcinoma
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
Carcinoma
SphK1-targeted miR-6784 inhibits functions of skin squamous cell carcinoma cells.
Carcinoma
Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis.
Carcinoma
Targeting sphingosine kinase 2 by ABC294640 inhibits human skin squamous cell carcinoma cell growth.
Carcinoma
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.
Carcinoma
The sphingosine kinase 2 inhibitor ABC294640 inhibits cervical carcinoma cell growth.
Carcinoma
[Adenovirus-mediated overexpression of KAI1 suppresses sphingosine kinase activation and metastasis of pancreatic carcinoma cells]
Carcinoma
[The expression and clinical significance of SphK1 and nuclear factor-?B p65 in human colon carcinoma].
Carcinoma, Ductal
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.
Carcinoma, Hepatocellular
Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.
Carcinoma, Hepatocellular
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Carcinoma, Hepatocellular
Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling.
Carcinoma, Hepatocellular
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2? and sphingosine kinase 1.
Carcinoma, Hepatocellular
HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
Carcinoma, Hepatocellular
KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2.
Carcinoma, Hepatocellular
Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).
Carcinoma, Hepatocellular
MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA.
Carcinoma, Hepatocellular
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Carcinoma, Hepatocellular
Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Sphingosine kinase 1 overexpression is associated with poor prognosis and oxaliplatin resistance in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice.
Carcinoma, Hepatocellular
Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor.
Carcinoma, Hepatocellular
SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells.
Carcinoma, Hepatocellular
SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/?-catenin signaling pathway.
Carcinoma, Hepatocellular
SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-?B pathway in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Sphk2 RNAi nanoparticles suppress tumor growth via downregulating cancer cell derived exosomal microRNA.
Carcinoma, Hepatocellular
Targeting SphK2 Reverses Acquired Resistance of Regorafenib in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
The impact of sphingosine kinase 1 on the prognosis of hepatocellular carcinoma patients with portal vein tumor thrombus.
Carcinoma, Hepatocellular
[Inhibitions of SphK1 inhibitor SKI II on cell cycle progression and cell invasion of hepatoma HepG2 cells].
Carcinoma, Non-Small-Cell Lung
ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Atorvastatin partially inhibits the epithelial-mesenchymal transition in A549 cells induced by TGF-?1 by attenuating the upregulation of SphK1.
Carcinoma, Non-Small-Cell Lung
LncRNA HULC promotes non-small cell lung cancer cell proliferation and inhibits the apoptosis by up-regulating sphingosine kinase 1 (SPHK1) and its downstream PI3K/Akt pathway.
Carcinoma, Non-Small-Cell Lung
LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1.
Carcinoma, Non-Small-Cell Lung
Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Sphingosine kinase 1 enhances the invasion and migration of non-small cell lung cancer cells via the AKT pathway.
Carcinoma, Non-Small-Cell Lung
Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-{kappa}B Pathway in Human Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine.
Carcinoma, Ovarian Epithelial
Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation.
Carcinoma, Ovarian Epithelial
Inhibition of sphingosine kinase 2 down-regulates ERK/c-Myc pathway and reduces cell proliferation in human epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer.
Carcinoma, Renal Cell
A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Sphingosine Kinase-1 Activation Causes Acquired Resistance Against Sunitinib in Renal Cell Carcinoma Cells.
Carcinoma, Squamous Cell
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Carcinoma, Squamous Cell
Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.
Carcinoma, Squamous Cell
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
Carcinoma, Squamous Cell
Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies.
Carcinoma, Squamous Cell
MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer.
Carcinoma, Squamous Cell
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
Carcinoma, Squamous Cell
SphK1-targeted miR-6784 inhibits functions of skin squamous cell carcinoma cells.
Carcinoma, Squamous Cell
Targeting sphingosine kinase 2 by ABC294640 inhibits human skin squamous cell carcinoma cell growth.
Carcinoma, Squamous Cell
The expression of sphingosine kinase-1 in head and neck carcinoma.
Cardiomyopathies
Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy.
Cardiovascular Diseases
Implication of sphingosin-1-phosphate in cardiovascular regulation.
Cardiovascular Diseases
Sphingosine kinase 1 (SK1) allosteric inhibitors that target the dimerization site.
Cerebral Infarction
Neuroprotective Effects of Danshen Chuanxiongqin Injection Against Ischemic Stroke: Metabolomic Insights by UHPLC-Q-Orbitrap HRMS Analysis.
Chagas Disease
Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy.
Cholangiocarcinoma
Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells.
Cholangiocarcinoma
Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas.
Cholangiocarcinoma
Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma.
Cholangiocarcinoma
Targeting sphingosine kinase 2 suppresses cell growth and synergizes with BCL2/BCL-XL inhibitors through NOXA-mediated MCL1 degradation in cholangiocarcinoma.
Chondrosarcoma
Sphingosine-1-phosphate promotes PDGF-dependent endothelial progenitor cell angiogenesis in human chondrosarcoma cells.
Chondrosarcoma
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression.
Chordoma
High expression of SPHK1 in sacral chordoma and association with patients' poor prognosis.
Colitis
Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice.
Colitis
Effect of the Sphingosine Kinase 1 Selective Inhibitor, PF543 on Dextran Sodium Sulfate-Induced Colitis in Mice.
Colitis
Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-?/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study.
Colitis
Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation.
Colitis
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
Colitis
Sphingosine-1-phosphate: Driver of NF?B and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer.
Colitis
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats.
Colitis, Ulcerative
Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway.
Colitis, Ulcerative
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Colitis, Ulcerative
Sphk1 promotes ulcerative colitis via activating JAK2/STAT3 signaling pathway.
Colitis, Ulcerative
Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase.
Colitis, Ulcerative
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats.
Colitis-Associated Neoplasms
Digestive Disease Week 2010. Turning Science into Medicine--part 2.
Colitis-Associated Neoplasms
Effects of triptolide on the sphingosine kinase - Sphingosine-1-phosphate signaling pathway in colitis-associated colon cancer.
Colitis-Associated Neoplasms
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Colitis-Associated Neoplasms
Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation.
Colitis-Associated Neoplasms
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.
Colitis-Associated Neoplasms
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Colitis-Associated Neoplasms
Sphingosine-1-phosphate: Driver of NF?B and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer.
Colitis-Associated Neoplasms
Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer.
Colonic Neoplasms
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Colonic Neoplasms
Down-regulation of sphingosine kinase 2 (SphK2) increases the effects of all-trans-retinoic acid (ATRA) on colon cancer cells.
Colonic Neoplasms
Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor.
Colonic Neoplasms
Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXR? by K48/K63-linked polyubiquitination.
Colonic Neoplasms
Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D.
Colonic Neoplasms
Sodium Butyrate Induces Apoptosis of Human Colon Cancer Cells by Modulating ERK and Sphingosine Kinase 2.
Colonic Neoplasms
Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways.
Colonic Neoplasms
Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
Colonic Neoplasms
Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells.
Colonic Neoplasms
Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population.
Colonic Neoplasms
Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules.
Colonic Neoplasms
Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells.
Colonic Neoplasms
Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target.
Colonic Neoplasms
Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation.
Colonic Neoplasms
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial?mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Colonic Neoplasms
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Colonic Neoplasms
SphK1 Promotes Cancer Progression through Activating JAK/STAT Pathway and Up-Regulating S1PR1 Expression in Colon Cancer Cells.
Colonic Neoplasms
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.
Colonic Neoplasms
[Down-regulation of sphingosine kinase 1 (SphK1) enhances the chemosensitivity to cisplatin in human colon cancer RKO cells].
Colonic Neoplasms
[Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer TH-29 cells and its molecular mechanisms].
Colonic Neoplasms
[Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer Lovo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1].
Colorectal Neoplasms
De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.
Colorectal Neoplasms
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Colorectal Neoplasms
Increased Sphingosine Kinase 1 Expression Predicts Distant Metastasis and Poor Outcome in Patients With Colorectal Cancer.
Colorectal Neoplasms
Inhibition of SPHK1 suppresses phorbol 12-myristate 13-acetate-induced metastatic phenotype in colorectal cancer HT-29 cells.
Colorectal Neoplasms
MicroRNA-101 down-regulates sphingosine kinase 1 in colorectal cancer cells.
Colorectal Neoplasms
MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2.
Colorectal Neoplasms
miR-659-3p is involved in the regulation of the chemotherapy response of colorectal cancer via modulating the expression of SPHK1.
Colorectal Neoplasms
Relationship of vasculogenic mimicry, SphK1 expression, and Cx43 expression to metastasis and prognosis in colorectal cancer.
Colorectal Neoplasms
Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer.
Colorectal Neoplasms
Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer.
Colorectal Neoplasms
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models.
Colorectal Neoplasms
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression.
Colorectal Neoplasms
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial?mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Colorectal Neoplasms
Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases.
Colorectal Neoplasms
SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells.
Colorectal Neoplasms
SphK1 promotes tumor cell migration and invasion in colorectal cancer.
Colorectal Neoplasms
SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulating H3K56ac-mediated DPD expression.
Colorectal Neoplasms
Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543.
Colorectal Neoplasms
Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.
Colorectal Neoplasms
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Colorectal Neoplasms
Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer.
Communicable Diseases
Cutting Edge: Modulation of Intestinal Autoimmunity and IL-2 Signaling by Sphingosine Kinase 2 Independent of Sphingosine 1-Phosphate.
Coronary Artery Disease
Transforming Growth Factor ?1 (TGF-?1) Appears to Promote Coronary Artery Disease by Upregulating Sphingosine Kinase 1 (SPHK1) and Further Upregulating Its Downstream TIMP-1.
COVID-19
Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19.
Crohn Disease
Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease.
Cryptococcosis
Role of host sphingosine kinase 1 in the lung response against Cryptococcosis.
Cryptococcosis
The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway.
Demyelinating Diseases
Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication.
Demyelinating Diseases
Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.
Dengue
Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs.
Dengue
Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways.
Dengue
Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection.
Dengue
Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type -2 RNA.
Dengue
Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses.
Dengue
RNAi screen reveals a role of SPHK2 in dengue virus-mediated apoptosis in hepatic cell lines.
Dengue
Tumour necrosis factor alpha (TNF-{alpha}) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-{alpha} to activate nuclear factor {kappa}B and reduced sphingosine kinase-1 activity.
Diabetes Mellitus
Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice.
Diabetes Mellitus, Type 2
Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice.
Diabetic Nephropathies
AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose.
Diabetic Nephropathies
Berberine suppresses high glucose-induced TGF-?1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathway.
Diabetic Nephropathies
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Diabetic Nephropathies
Sphingosine kinase 1 mediates AGEs-induced fibronectin upregulation in diabetic nephropathy.
Diabetic Nephropathies
Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.
Diffuse Intrinsic Pontine Glioma
Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG).
Encephalomyelitis
Effect of sphingosine kinase modulators on interleukin-1? release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.
Encephalomyelitis
Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments.
Encephalomyelitis, Autoimmune, Experimental
Effect of sphingosine kinase modulators on interleukin-1? release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments.
Endometriosis
Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells.
Endometriosis
Targeting sphingosine kinase-1 with the low MW inhibitor SKI-5C suppresses the development of endometriotic lesions in mice.
Epilepsy
Spatiotemporal Expression of SphK1 and S1PR2 in the Hippocampus of Pilocarpine Rat Model and the Epileptic Foci of Temporal Lobe Epilepsy.
Epilepsy, Temporal Lobe
Spatiotemporal Expression of SphK1 and S1PR2 in the Hippocampus of Pilocarpine Rat Model and the Epileptic Foci of Temporal Lobe Epilepsy.
Epstein-Barr Virus Infections
Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3.
Esophageal Neoplasms
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR?378a?5p to enhance SPHK1 expression.
Esophageal Squamous Cell Carcinoma
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
Fetal Death
Sphingolipid Pathway Regulates Innate Immune Responses at the Fetomaternal Interface during Pregnancy.
Fibroadenoma
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Frontotemporal Dementia
Autophagy and ALS: mechanistic insights and therapeutic implications.
Gastrointestinal Diseases
Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target.
Glioblastoma
A bidirectional crosstalk between glioblastoma and brain endothelial cells potentiates the angiogenic and proliferative signaling of sphingosine-1-phosphate in the glioblastoma microenvironment.
Glioblastoma
A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
Glioblastoma
A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy.
Glioblastoma
A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.
Glioblastoma
Comparative analysis of the effects of a sphingosine kinase inhibitor to temozolomide and radiation treatment on glioblastoma cell lines.
Glioblastoma
Cross-talk between sphingosine-1-phosphate and EGFR signaling pathways enhances human glioblastoma cell invasiveness.
Glioblastoma
Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma.
Glioblastoma
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.
Glioblastoma
Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells.
Glioblastoma
Sphingosine Kinase Inhibitors as Maintenance Therapy of Glioblastoma After Ceramide-Induced Response.
Glioblastoma
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines.
Glioblastoma
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
Glioblastoma
The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.
Glioblastoma
The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells.
Glioblastoma
[Sphingosine kinase 1 promotes glioma cell proliferation under hypoxia via calcium signaling].
Glioma
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.
Glioma
Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal-regulated kinase.
Glioma
Interaction between transcription factors PAX6/PAX6-5a and specific members of miR-183-96-182 cluster, may contribute to glioma progression in glioblastoma cell lines.
Glioma
Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells.
Glioma
MicroRNA-28-5p regulates glioma cell proliferation, invasion and migration by targeting SphK1.
Glioma
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.
Glioma
Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness.
Glioma
Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma.
Glioma
Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.
Glioma
Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.
Glioma
Sphingosine?1?phosphate analogue FTY720 exhibits a potent anti?proliferative effect on glioblastoma cells.
Glioma
SPHK2 protein expression, Ki-67 index and infiltration of tumor-associated macrophages (TAMs) in human glioma.
Glioma
Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG).
Glioma
The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells.
Glioma
Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy.
Glioma
[Sphingosine kinase 1 promotes glioma cell proliferation under hypoxia via calcium signaling].
Glomerulonephritis
Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity.
Glomerulonephritis
Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases.
Glomerulosclerosis, Focal Segmental
Resveratrol Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis through C3aR/C5aR- Sphingosine Kinase 1 Pathway.
Glucose Intolerance
Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice.
Glucose Intolerance
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Goiter, Nodular
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Granuloma
Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.
Granuloma
The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway.
Heart Failure
Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?
Hematologic Neoplasms
Regulation of Sphingosine Kinase in Hematological Malignancies and Other Cancers.
Hemorrhagic Fever, Ebola
The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection.
Hepatitis B
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2? and sphingosine kinase 1.
Hepatitis C
Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis.
Hepatoblastoma
Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma.
Huntington Disease
Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.
Huntington Disease
Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model.
Huntington Disease
Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease.
Hyperalgesia
Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism.
Hyperalgesia
Sphingosine-1-phosphate acting via the S1P? receptor is a downstream signaling pathway in ceramide-induced hyperalgesia.
Hyperglycemia
Activation of sphingosine kinase-1 mediates inhibition of vascular smooth muscle cell apoptosis by hyperglycemia.
Hyperglycemia
Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells.
Hyperlipidemias
Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.
Hypersensitivity
Allergy therapy: the therapeutic potential of targeting sphingosine kinase signalling in mast cells.
Hypertension
Commentary: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Hypertension
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Hypertension
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies.
Hypertension
Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel.
Hypertension
Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells.
Hypertension
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.
Hypertension
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-?B activation.
Hypertension
Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension.
Hypertension
T-Cell Accumulation in the Hypertensive Brain: A Role for Sphingosine-1-Phosphate-Mediated Chemotaxis.
Hypertension
Targeting sphingosine kinase 1 for the treatment of pulmonary arterial hypertension.
Hypertension
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Hypertension
Vascular transcriptome profiling identifies Sphingosine kinase 1 as a modulator of angiotensin II-induced vascular dysfunction.
Hypertension, Pulmonary
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Hypertension, Pulmonary
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.
Hypertension, Pulmonary
Sphingosine kinase 1/sphingosine 1-phosphate signalling pathway as a potential therapeutic target of pulmonary hypertension.
Hypertension, Pulmonary
Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?
Hypertrophy, Right Ventricular
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Hypertrophy, Right Ventricular
Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension.
Hypoxia, Brain
Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke.
Idiopathic Pulmonary Fibrosis
Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.
Immune System Diseases
Tumor necrosis factor-induced neutrophil adhesion occurs via sphingosine kinase-1-dependent activation of endothelial {alpha}5{beta}1 integrin.
Infarction, Middle Cerebral Artery
Junctional protein regulation by sphingosine kinase 2 contributes to blood-brain barrier protection in hypoxic preconditioning-induced cerebral ischemic tolerance.
Infarction, Middle Cerebral Artery
Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke.
Infarction, Middle Cerebral Artery
Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia.
Infarction, Middle Cerebral Artery
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.
Infections
Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and inflammation in mouse lung.
Infections
In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria.
Infections
In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection.
Infections
Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways.
Infections
Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection.
Infections
Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.
Infections
Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type -2 RNA.
Infections
RNAi screen reveals a role of SPHK2 in dengue virus-mediated apoptosis in hepatic cell lines.
Infections
S1P Increases VEGF Production in Osteoblasts and Facilitates Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-16-5p Expression via the c-Src/FAK Signaling Pathway in Rheumatoid Arthritis.
Infections
Sphingolipids Are Dual Specific Drug Targets for the Management of Pulmonary Infections: Perspective.
Infections
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.
Infections
Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex.
Infections
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.
Infections
Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages.
Infections
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice.
Infections
Tumour necrosis factor alpha (TNF-{alpha}) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-{alpha} to activate nuclear factor {kappa}B and reduced sphingosine kinase-1 activity.
Inflammatory Bowel Diseases
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Inflammatory Bowel Diseases
Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.
Inflammatory Bowel Diseases
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
Inflammatory Bowel Diseases
Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis.
Inflammatory Bowel Diseases
Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-?/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study.
Inflammatory Bowel Diseases
Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Inflammatory Bowel Diseases
Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway.
Inflammatory Bowel Diseases
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
Inflammatory Bowel Diseases
Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases.
Influenza, Human
Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?
Influenza, Human
Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System.
Influenza, Human
Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.
Influenza, Human
Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.
Influenza, Human
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice.
Insulin Resistance
Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice.
Insulin Resistance
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
Insulin Resistance
Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes.
Insulin Resistance
Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High Fat-Fed Mice.
Insulin Resistance
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Insulin Resistance
Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance.
Insulinoma
Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line.
Insulinoma
Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines.
Intestinal Neoplasms
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
Keloid
[Expression and function of sphingosine kinases 1 and 2 in human keloid fibroblasts]
Kidney Diseases
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Leiomyoma
Endothelin-1 inhibits apoptosis through a sphingosine kinase 1-dependent mechanism in uterine leiomyoma ELT3 cells.
Leiomyoma
Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect.
Leishmaniasis
Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence.
Leishmaniasis
Sphingosine-1-phosphate signaling in Leishmania donovani infection in macrophages.
Leukemia
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Leukemia
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.
Leukemia
Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent.
Leukemia
Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1.
Leukemia
Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling.
Leukemia
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.
Leukemia
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.
Leukemia
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Leukemia
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells.
Leukemia
Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins.
Leukemia
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.
Leukemia
Regulation of sphingosine kinase 1 gene expression by protein kinase C in a human leukemia cell line, MEG-O1.
Leukemia
Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway.
Leukemia
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria.
Leukemia
Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.
Leukemia
v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins.
Leukemia, Erythroblastic, Acute
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.
Leukemia, Erythroblastic, Acute
Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity.
Leukemia, Large Granular Lymphocytic
Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
MiR-659-3p regulates the progression of chronic myeloid leukemia by targeting SPHK1.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells.
Leukemia, Myeloid
Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells.
Leukemia, Myeloid, Acute
Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1.
Leukemia, Myeloid, Acute
Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function.
Leukemia, Myeloid, Acute
SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models.
Leukemia, Myeloid, Acute
SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo.
Leukemia, Myeloid, Acute
Targeting sphingosine kinase 1 in acute myeloid leukemia: translation to clinic.
Leukemia, Myeloid, Acute
Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.
Leukemia, Myeloid, Acute
The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.
Liver Cirrhosis
Bone marrow-derived mesenchymal stem cells differentiate to hepatic myofibroblasts by transforming growth factor-?1 via sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis.
Liver Cirrhosis
Leucine-rich Repeats and Immunoglobulin 1 (LRIG1) Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation via Inhibiting Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P) Pathway.
Liver Cirrhosis
Polydatin attenuates hepatic stellate cell proliferation and liver fibrosis by suppressing sphingosine kinase 1.
Liver Cirrhosis
Salidroside Inhibits CCl4-Induced Liver Fibrosis in Mice by Reducing Activation and Migration of HSC Induced by Liver Sinusoidal Endothelial Cell-Derived Exosomal SphK1.
Liver Cirrhosis
Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2.
Liver Cirrhosis
Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis is Involved in Liver Fibrosis-Associated Angiogenesis.
Liver Diseases
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
Liver Diseases
Generation of mice with hepatocyte-specific conditional deletion of sphingosine kinase 1.
Liver Diseases
Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin.
Liver Diseases
Sphingosine-1-phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
Liver Failure, Acute
C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure.
Liver Failure, Acute
Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNF?-dependent inflammation and apoptosis.
Liver Failure, Acute
Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells.
Liver Failure, Acute
Sphingosine kinase 1 dependent protein kinase C-? activation plays an important role in acute liver failure in mice.
Liver Failure, Acute
Sphingosine kinase 1 inhibition improves lipopolysaccharide/D-galactosamine-induced acute liver failure by inhibiting mitogen-activated protein kinases pathway.
Liver Neoplasms
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Liver Neoplasms
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2? and sphingosine kinase 1.
Liver Neoplasms
Inhibition of sphingosine kinase 1 enhances cytotoxicity, ceramide levels and ROS formation in liver cancer cells treated with selenite.
Liver Neoplasms
Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).
Liver Neoplasms
MicroRNA-338-3p suppresses proliferation of human liver cancer cells by targeting SphK2.
Liver Neoplasms
MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA.
Lung Injury
Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication Mice.
Lung Injury
Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats.
Lung Injury
Expression of sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 in malaria-associated acute lung injury/acute respiratory distress syndrome in a mouse model.
Lung Injury
Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia.
Lung Injury
Inhibition of Sphingosine Kinase 1 Attenuates Sepsis-induced Microvascular Leakage via Inhibiting Macrophage NLRP3 Inflammasome Activation in Mice.
Lung Injury
Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe Plasmodium falciparum Malaria with Pulmonary Edema.
Lung Injury
Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury.
Lung Neoplasms
ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer.
Lung Neoplasms
Atorvastatin partially inhibits the epithelial-mesenchymal transition in A549 cells induced by TGF-?1 by attenuating the upregulation of SphK1.
Lung Neoplasms
Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.
Lung Neoplasms
Circular RNA HIPK3 exerts oncogenic properties through suppression of miR-124 in lung cancer.
Lung Neoplasms
Discovery of Harmaline as a Potent Inhibitor of Sphingosine Kinase-1: A Chemopreventive Role in Lung Cancer.
Lung Neoplasms
DMS triggers apoptosis associated with the inhibition of SPHK1/NF-?B activation and increase in intracellular Ca2+ concentration in human cancer cells.
Lung Neoplasms
Epithelial mesenchymal transition of non-small-cell lung cancer cells A549 induced by SPHK1.
Lung Neoplasms
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells.
Lung Neoplasms
Increased SPK1 expression promotes cell growth by activating the ERK1/2 signaling in non-small-cell lung cancer.
Lung Neoplasms
Inhibition of ceramide glucosylation sensitizes lung cancer cells to ABC294640, a first-in-class small molecule SphK2 inhibitor.
Lung Neoplasms
LncRNA HULC promotes non-small cell lung cancer cell proliferation and inhibits the apoptosis by up-regulating sphingosine kinase 1 (SPHK1) and its downstream PI3K/Akt pathway.
Lung Neoplasms
LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1.
Lung Neoplasms
MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2.
Lung Neoplasms
Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer.
Lung Neoplasms
Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer.
Lung Neoplasms
Sphingosine kinase 1 enhances the invasion and migration of non-small cell lung cancer cells via the AKT pathway.
Lung Neoplasms
Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-{kappa}B Pathway in Human Non-Small Cell Lung Cancer.
Lung Neoplasms
Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine.
Lung Neoplasms
SphK1 functions downstream of IGF-1 to modulate IGF-1-induced EMT, migration and paclitaxel resistance of A549 cells: A preliminary in vitro study.
Lung Neoplasms
SphK1 promotes development of non?small cell lung cancer through activation of STAT3.
Lung Neoplasms
The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo.
Lung Neoplasms
[Role of SPHK1 regulates multi-drug resistance of small cell lung cancer ?and its clinical significance].
Lupus Erythematosus, Systemic
Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.
Lymphatic Metastasis
Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer.
Lymphatic Metastasis
Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis.
Lymphatic Metastasis
Inhibition of sphingosine kinase 2 down-regulates ERK/c-Myc pathway and reduces cell proliferation in human epithelial ovarian cancer.
Lymphatic Metastasis
Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer.
Lymphatic Metastasis
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Lymphatic Metastasis
Relationship of vasculogenic mimicry, SphK1 expression, and Cx43 expression to metastasis and prognosis in colorectal cancer.
Lymphatic Metastasis
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Lymphatic Metastasis
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.
Lymphatic Metastasis
Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules.
Lymphatic Metastasis
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
Lymphatic Metastasis
SphK1 promotes tumor cell migration and invasion in colorectal cancer.
Lymphatic Metastasis
Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.
Lymphocytic Choriomeningitis
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.
Lymphoma
Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract.
Lymphoma
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions.
Lymphoma
Sphingosine Kinase Blockade Leads to Increased Natural Killer T Cell Responses to Mantle Cell Lymphoma.
Lymphoma
Sphingosine kinase is an attractive target for novel pharmacological interventions in non-Hodgkin lymphomas.
Lymphoma
Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells.
Lymphoma
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
Lymphoma, B-Cell
Hesperidin modulates dextran sulfate sodium-induced ulcerative colitis in rats: Targeting sphingosine kinase-1- sphingosine 1 phosphate signaling pathway, mitochondrial biogenesis, inflammation, and apoptosis.
Lymphoma, Large B-Cell, Diffuse
Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors.
Lymphoma, Mantle-Cell
Sphingosine Kinase Blockade Leads to Increased Natural Killer T Cell Responses to Mantle Cell Lymphoma.
Lymphoma, Primary Effusion
Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells.
Lymphoma, Primary Effusion
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
Lymphopenia
Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate.
Lymphopenia
New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth.
Lymphopenia
Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia.
Lymphopenia
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720.
Lymphopenia
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.
Macular Degeneration
Immunohistochemical Detection of Sphingosine-1-Phosphate and Sphingosine Kinase-1 in Human Tissue Samples and Cell Lines.
Macular Degeneration
Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples.
Malaria
Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe Plasmodium falciparum Malaria with Pulmonary Edema.
Malaria
Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes.
Malaria, Falciparum
Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe Plasmodium falciparum Malaria with Pulmonary Edema.
Massive Hepatic Necrosis
Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNF?-dependent inflammation and apoptosis.
Massive Hepatic Necrosis
Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin.
Measles
Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro.
Melanoma
Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma.
Melanoma
Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells.
Melanoma
Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration.
Melanoma
Increasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition.
Melanoma
Involvement of vacuolar H(+) -ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720.
Melanoma
Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity.
Melanoma
Regulation of nonclassical fgf1 release and fgf-dependent cell transformation by CBF1-mediated notch signaling.
Melanoma
Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1.
Melanoma
Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis.
Melanoma
Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression.
Mesothelioma
Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.
Metabolic Diseases
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
Metabolic Diseases
K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.
Metabolic Syndrome
K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.
Metabolic Syndrome
SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes.
Multiple Endocrine Neoplasia Type 2a
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
Multiple Myeloma
Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis.
Multiple Myeloma
Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
Multiple Myeloma
Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs.
Multiple Sclerosis
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Multiple Sclerosis
FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Multiple Sclerosis
FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.
Multiple Sclerosis
Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor.
Multiple Sclerosis
Immunohistochemical Detection of Sphingosine-1-Phosphate and Sphingosine Kinase-1 in Human Tissue Samples and Cell Lines.
Multiple Sclerosis
Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples.
Multiple Sclerosis
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
Myelodysplastic Syndromes
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells.
Myocardial Ischemia
Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.
Nasopharyngeal Carcinoma
High expression of sphingosine kinase 1 is associated with poor prognosis in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.
Neoplasm Metastasis
A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
Neoplasm Metastasis
Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase.
Neoplasm Metastasis
An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma.
Neoplasm Metastasis
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.
Neoplasm Metastasis
Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis.
Neoplasm Metastasis
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.
Neoplasm Metastasis
Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma.
Neoplasm Metastasis
Epithelial mesenchymal transition of non-small-cell lung cancer cells A549 induced by SPHK1.
Neoplasm Metastasis
Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer.
Neoplasm Metastasis
Functional implications of pH-induced conformational changes in the Sphingosine kinase 1.
Neoplasm Metastasis
Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis.
Neoplasm Metastasis
High expression of sphingosine kinase 1 is associated with poor prognosis in nasopharyngeal carcinoma.
Neoplasm Metastasis
Hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat.
Neoplasm Metastasis
HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma.
Neoplasm Metastasis
Increased Sphingosine Kinase 1 Expression Predicts Distant Metastasis and Poor Outcome in Patients With Colorectal Cancer.
Neoplasm Metastasis
Inhibition of sphingosine kinase 2 down-regulates ERK/c-Myc pathway and reduces cell proliferation in human epithelial ovarian cancer.
Neoplasm Metastasis
Inhibitory effects of novel SphK2 inhibitors on migration of cancer cells.
Neoplasm Metastasis
Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer.
Neoplasm Metastasis
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
Neoplasm Metastasis
MiR-128 suppresses the growth of thyroid carcinoma by negatively regulating SPHK1.
Neoplasm Metastasis
MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2.
Neoplasm Metastasis
Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer.
Neoplasm Metastasis
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.
Neoplasm Metastasis
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Neoplasm Metastasis
Relationship of vasculogenic mimicry, SphK1 expression, and Cx43 expression to metastasis and prognosis in colorectal cancer.
Neoplasm Metastasis
Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.
Neoplasm Metastasis
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Neoplasm Metastasis
Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.
Neoplasm Metastasis
Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis.
Neoplasm Metastasis
Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.
Neoplasm Metastasis
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.
Neoplasm Metastasis
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.
Neoplasm Metastasis
Sphingosine kinase 1 is required for TGF-? mediated fibroblastto- myofibroblast differentiation in ovarian cancer.
Neoplasm Metastasis
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
Neoplasm Metastasis
Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules.
Neoplasm Metastasis
Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.
Neoplasm Metastasis
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression.
Neoplasm Metastasis
Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance.
Neoplasm Metastasis
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial?mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Neoplasm Metastasis
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Neoplasm Metastasis
Sphingosine-1-phosphate promotes PDGF-dependent endothelial progenitor cell angiogenesis in human chondrosarcoma cells.
Neoplasm Metastasis
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression.
Neoplasm Metastasis
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
Neoplasm Metastasis
SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells.
Neoplasm Metastasis
SPHK1 promotes metastasis of thyroid carcinoma through activation of the S1P/S1PR3/Notch signaling pathway.
Neoplasm Metastasis
SphK1-driven autophagy potentiates focal adhesion paxillin-mediated metastasis in colorectal cancer.
Neoplasm Metastasis
SphK2/S1P Promotes Metastasis of Triple-Negative Breast Cancer Through the PAK1/LIMK1/Cofilin1 Signaling Pathway.
Neoplasm Metastasis
TGF?-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis.
Neoplasm Metastasis
The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.
Neoplasm Metastasis
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
Neoplasm Metastasis
Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.
Neoplasm Metastasis
[Adenovirus-mediated overexpression of KAI1 suppresses sphingosine kinase activation and metastasis of pancreatic carcinoma cells]
Neoplasm Metastasis
[Relationship between sphingosine kinase 1 expression and tumor invasion, metastasis and prognosis in gastric cancer].
Neoplasms
1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.
Neoplasms
213Bi-induced death of HSC45-M2 gastric cancer cells is characterized by G2 arrest and up-regulation of genes known to prevent apoptosis but induce necrosis and mitotic catastrophe.
Neoplasms
A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme Assay.
Neoplasms
A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
Neoplasms
A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
Neoplasms
A novel sphingosine kinase 1 inhibitor (SKI-5C) induces cell death of Wilms' tumor cells
Neoplasms
A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.
Neoplasms
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Neoplasms
A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.
Neoplasms
A Stilbenoid Isorhapontigenin as a Potential Anti-Cancer Agent against Breast Cancer through Inhibiting Sphingosine Kinases/Tubulin Stabilization.
Neoplasms
ABC294640, a novel sphingosine kinase 2 inhibitor induces oncogenic virus infected cell autophagic death and represses tumor growth.
Neoplasms
ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer.
Neoplasms
ABCC1-exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1 Shortens Survival of Mice and Patients with Breast Cancer.
Neoplasms
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
Neoplasms
Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells.
Neoplasms
Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting.
Neoplasms
Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes.
Neoplasms
Alphastatin downregulates vascular endothelial cells sphingosine kinase activity and suppresses tumor growth in nude mice bearing human gastric cancer xenografts.
Neoplasms
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
Neoplasms
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Neoplasms
An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines.
Neoplasms
An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.
Neoplasms
Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice.
Neoplasms
Anti-cancer effect of pristimerin by inhibition of HIF-1? involves the SPHK-1 pathway in hypoxic prostate cancer cells.
Neoplasms
Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.
Neoplasms
Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells.
Neoplasms
Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.
Neoplasms
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.
Neoplasms
Bone Marrow-Derived Mesenchymal Stem Cells Differentially Affect Glioblastoma Cell Proliferation, Migration, and Invasion: A 2D-DIGE Proteomic Analysis.
Neoplasms
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Neoplasms
Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors.
Neoplasms
Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression.
Neoplasms
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.
Neoplasms
Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer.
Neoplasms
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Neoplasms
De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.
Neoplasms
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Neoplasms
Design and Development of Novel Urea, Sulfonyltriurea, and Sulfonamide Derivatives as Potential Inhibitors of Sphingosine Kinase 1.
Neoplasms
Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors.
Neoplasms
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.
Neoplasms
Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor.
Neoplasms
Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry.
Neoplasms
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.
Neoplasms
Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas.
Neoplasms
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.
Neoplasms
Divergence of Intracellular Trafficking of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 3 in MCF-7 Breast Cancer Cells and MCF-7-Derived Stem Cell-Enriched Mammospheres.
Neoplasms
Down regulation of lncRNA MEG3 promotes colorectal adenocarcinoma cell proliferation and inhibits the apoptosis by up-regulating TGF-?1 and its downstream sphingosine kinase 1.
Neoplasms
Down-regulation of sphingosine kinase 2 (SphK2) increases the effects of all-trans-retinoic acid (ATRA) on colon cancer cells.
Neoplasms
Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.
Neoplasms
Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma.
Neoplasms
Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.
Neoplasms
Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells.
Neoplasms
E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin ?v?6 and maintained through TGF? signalling.
Neoplasms
Emerging Connections of S1P-Metabolizing Enzymes with Host Defense and Immunity During Virus Infections.
Neoplasms
Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma.
Neoplasms
Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium.
Neoplasms
Evaluation of binding and inhibition mechanism of dietary phytochemicals with sphingosine kinase 1: Towards targeted anticancer therapy.
Neoplasms
Evaluation of ellagic acid as an inhibitor of sphingosine kinase 1: A targeted approach towards anticancer therapy.
Neoplasms
Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming.
Neoplasms
Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase.
Neoplasms
Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer.
Neoplasms
Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma.
Neoplasms
Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion.
Neoplasms
Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors.
Neoplasms
First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.
Neoplasms
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model.
Neoplasms
FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression.
Neoplasms
Functional implications of pH-induced conformational changes in the Sphingosine kinase 1.
Neoplasms
Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis.
Neoplasms
Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model.
Neoplasms
Glabridin Suppresses Intercellular Adhesion Molecule-1 Expression in Tumor Necrosis Factor-{alpha}-Stimulated Human Umbilical Vein Endothelial Cells by Blocking Sphingosine Kinase Pathway: Implications of Akt, Extracellular Signal-Regulated Kinase, and Nuclear Factor-{kappa}B/Rel Signaling Pathways.
Neoplasms
Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor.
Neoplasms
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2? and sphingosine kinase 1.
Neoplasms
High expression of sphingosine kinase 1 is associated with poor prognosis in nasopharyngeal carcinoma.
Neoplasms
High expression of SPHK1 in sacral chordoma and association with patients' poor prognosis.
Neoplasms
Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation.
Neoplasms
Hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat.
Neoplasms
HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma.
Neoplasms
Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.
Neoplasms
Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells.
Neoplasms
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Neoplasms
Immunohistochemical Detection of Sphingosine-1-Phosphate and Sphingosine Kinase-1 in Human Tissue Samples and Cell Lines.
Neoplasms
Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples.
Neoplasms
Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue.
Neoplasms
Importance of Sphingosine Kinase (SphK) as a Target in Developing Cancer Therapeutics and Recent Developments in the Synthesis of Novel SphK Inhibitors.
Neoplasms
In Silico Characterization of Structural Distinctions between Isoforms of Human and Mouse Sphingosine Kinases for Accelerating Drug Discovery.
Neoplasms
In Silico Identification of Novel Orthosteric Inhibitors of Sphingosine Kinase 1 (SK1).
Neoplasms
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Neoplasms
Increased Sphingosine Kinase 1 Expression Predicts Distant Metastasis and Poor Outcome in Patients With Colorectal Cancer.
Neoplasms
Increased SPK1 expression promotes cell growth by activating the ERK1/2 signaling in non-small-cell lung cancer.
Neoplasms
Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.
Neoplasms
Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.
Neoplasms
Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade.
Neoplasms
Inhibition of ceramide glucosylation sensitizes lung cancer cells to ABC294640, a first-in-class small molecule SphK2 inhibitor.
Neoplasms
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
Neoplasms
Inhibition of SPHK1 suppresses phorbol 12-myristate 13-acetate-induced metastatic phenotype in colorectal cancer HT-29 cells.
Neoplasms
Inhibition of SphK2 Stimulated Hepatic Gluconeogenesis Associated with Dephosphorylation and Deacetylation of STAT3.
Neoplasms
Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer.
Neoplasms
Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation.
Neoplasms
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
Neoplasms
Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.
Neoplasms
Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation.
Neoplasms
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
Neoplasms
Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin.
Neoplasms
LC-HRMS based approach to identify novel sphingolipid biomarkers in breast cancer patients.
Neoplasms
Lentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma.
Neoplasms
LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR?378a?5p to enhance SPHK1 expression.
Neoplasms
Long Intergenic Nonprotein Coding RNA 173 Inhibits Tumor Growth and Promotes Apoptosis by Repressing Sphingosine Kinase 1 Protein Expression in Pancreatic Cancer.
Neoplasms
Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).
Neoplasms
Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.
Neoplasms
Mechanistic insights into the urea-induced denaturation of human sphingosine kinase 1.
Neoplasms
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
Neoplasms
MicroRNA-28-5p regulates glioma cell proliferation, invasion and migration by targeting SphK1.
Neoplasms
MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2.
Neoplasms
MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2.
Neoplasms
MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.
Neoplasms
miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1.
Neoplasms
MiR-128 suppresses the growth of thyroid carcinoma by negatively regulating SPHK1.
Neoplasms
MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2.
Neoplasms
MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA.
Neoplasms
MiR-577 inhibits papillary thyroid carcinoma cell proliferation, migration and invasion by targeting SphK2.
Neoplasms
miR-613 inhibits bladder cancer proliferation and migration through targeting SphK1.
Neoplasms
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
Neoplasms
New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth.
Neoplasms
New insights into the roles and regulation of SphK2 as a therapeutic target in cancer chemoresistance.
Neoplasms
NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells.
Neoplasms
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy.
Neoplasms
Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer.
Neoplasms
Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway.
Neoplasms
Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer.
Neoplasms
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Neoplasms
Pharmacological Inhibition of Sphingosine Kinase Isoforms Alters Estrogen Receptor Signaling in Human Breast Cancer.
Neoplasms
Polarization of the innate immune response by prostaglandin E2: a puzzle of receptors and signals.
Neoplasms
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.
Neoplasms
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Neoplasms
Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors.
Neoplasms
Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer.
Neoplasms
Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.
Neoplasms
Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.
Neoplasms
Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.
Neoplasms
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate.
Neoplasms
Regulation of Sphingosine Kinase in Hematological Malignancies and Other Cancers.
Neoplasms
Relationship of vasculogenic mimicry, SphK1 expression, and Cx43 expression to metastasis and prognosis in colorectal cancer.
Neoplasms
Resveratrol Dimers Are Novel Sphingosine Kinase 1 Inhibitors and Affect Sphingosine Kinase 1 Expression and Cancer Cell Growth and Survival.
Neoplasms
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
Neoplasms
RNAi screen reveals a role of SPHK2 in dengue virus-mediated apoptosis in hepatic cell lines.
Neoplasms
Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.
Neoplasms
Role of Sphingosine Kinase in the Expression of Adhesion Molecules on Monocytes Induced by Tumor Necrosis Factor-Alpha (Relevant to Atherosclerosis).
Neoplasms
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.
Neoplasms
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Neoplasms
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
Neoplasms
Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D.
Neoplasms
SK1 inhibitor RB005 Induces Apoptosis in Colorectal Cancer Cells through SK1 Inhibition Dependent and Independent Pathway.
Neoplasms
Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances.
Neoplasms
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria.
Neoplasms
Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RAR? expression.
Neoplasms
Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.
Neoplasms
Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers.
Neoplasms
Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro.
Neoplasms
Sphingosine kinase 1 (SK1) allosteric inhibitors that target the dimerization site.
Neoplasms
Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.
Neoplasms
Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation.
Neoplasms
Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways.
Neoplasms
Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
Neoplasms
Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.
Neoplasms
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.
Neoplasms
Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression.
Neoplasms
Sphingosine kinase 1 is overexpressed and promotes proliferation in human thyroid cancer.
Neoplasms
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.
Neoplasms
Sphingosine kinase 1 is required for TGF-? mediated fibroblastto- myofibroblast differentiation in ovarian cancer.
Neoplasms
Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.
Neoplasms
Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer.
Neoplasms
Sphingosine kinase 1 knockout alleviates hepatic ischemia/reperfusion injury by attenuating inflammation and oxidative stress in mice.
Neoplasms
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
Neoplasms
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models.
Neoplasms
Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma.
Neoplasms
Sphingosine kinase 1 overexpression is associated with poor prognosis and oxaliplatin resistance in hepatocellular carcinoma.
Neoplasms
Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population.
Neoplasms
Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules.
Neoplasms
Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.
Neoplasms
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions.
Neoplasms
Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.
Neoplasms
Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1.
Neoplasms
Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor ?B Activation.
Neoplasms
Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.
Neoplasms
Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.
Neoplasms
Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma.
Neoplasms
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.
Neoplasms
Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression.
Neoplasms
Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.
Neoplasms
Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target.
Neoplasms
Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells.
Neoplasms
Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2.
Neoplasms
Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography.
Neoplasms
Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.
Neoplasms
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.
Neoplasms
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
Neoplasms
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
Neoplasms
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.
Neoplasms
Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens.
Neoplasms
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines.
Neoplasms
Sphingosine kinase-1 inhibition sensitizes curcumin-induced growth inhibition and apoptosis in ovarian cancer cells.
Neoplasms
Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs.
Neoplasms
Sphingosine kinase-2 Inhibitor ABC294640 Enhances Doxorubicin-Induced Apoptosis of NSCLC Cells via Altering Survivin Expression.
Neoplasms
Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1.
Neoplasms
Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance.
Neoplasms
Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth.
Neoplasms
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Neoplasms
Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation.
Neoplasms
Sphingosine-1-phosphate signalling drives an angiogenic transcriptional programme in diffuse large B cell lymphoma.
Neoplasms
Sphingosine-1-phosphate: Driver of NF?B and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer.
Neoplasms
Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer.
Neoplasms
SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/?-catenin signaling pathway.
Neoplasms
SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-?B pathway in hepatocellular carcinoma.
Neoplasms
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-?B pathways in activated microglia in cerebral ischemia reperfusion.
Neoplasms
Sphk1 participates in malignant progression of breast cancer by regulating epithelial-mesenchymal transition and stem cell characteristics.
Neoplasms
Sphk1 promotes breast epithelial cell proliferation via NF-?B-p65-mediated cyclin D1 expression.
Neoplasms
SphK1 Promotes Cancer Progression through Activating JAK/STAT Pathway and Up-Regulating S1PR1 Expression in Colon Cancer Cells.
Neoplasms
SphK1-driven autophagy potentiates focal adhesion paxillin-mediated metastasis in colorectal cancer.
Neoplasms
SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells.
Neoplasms
Sphk2 RNAi nanoparticles suppress tumor growth via downregulating cancer cell derived exosomal microRNA.
Neoplasms
Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.
Neoplasms
Structure-activity relationship studies and bioactivity evaluation of 1,2,3-triazole containing analogues as a selective sphingosine kinase-2 inhibitors.
Neoplasms
Suppression of breast xenograft growth and progression in nude mice: implications for the use of orally administered sphingolipids as chemopreventive agents against breast cancer.
Neoplasms
Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.
Neoplasms
Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
Neoplasms
Targeting Ovarian Cancer and Chemoresistance Through Selective Inhibition of Sphingosine Kinase-2 with ABC294640.
Neoplasms
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats.
Neoplasms
Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.
Neoplasms
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
Neoplasms
Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy.
Neoplasms
Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.
Neoplasms
Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.
Neoplasms
The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells.
Neoplasms
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.
Neoplasms
The impact of sphingosine kinase 1 on the prognosis of hepatocellular carcinoma patients with portal vein tumor thrombus.
Neoplasms
The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells.
Neoplasms
The Importance of Sphingosine Kinase in Breast Cancer: A Potential for Breast Cancer Management.
Neoplasms
The Relationship of Sphingosine Kinase 1 With Pyroptosis Provides a New Strategy for Tumor Therapy.
Neoplasms
The role of sphingosine kinase and sphingosine-1-phosphate in the regulation of endothelial cell biology.
Neoplasms
The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.
Neoplasms
The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells.
Neoplasms
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.
Neoplasms
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
Neoplasms
The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.
Neoplasms
The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy.
Neoplasms
The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target.
Neoplasms
Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.
Neoplasms
TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.
Neoplasms
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
Neoplasms
Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.
Neoplasms
Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway.
Neoplasms
Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.
Neoplasms
Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression.
Neoplasms
Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes.
Neoplasms
Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde.
Neoplasms
Tumour necrosis factor alpha (TNF-{alpha}) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-{alpha} to activate nuclear factor {kappa}B and reduced sphingosine kinase-1 activity.
Neoplasms
Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy.
Neoplasms
Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.
Neoplasms
Up-regulation of tumor suppressor genes by exogenous dhC16-Cer contributes to its anti-cancer activity in primary effusion lymphoma.
Neoplasms
Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer.
Neoplasms
Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.
Neoplasms
v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins.
Neoplasms
Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity.
Neoplasms
When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.
Neoplasms
[Regulation of sphingosine kinase 1 in the TNF-?-induced expression of MUC5AC in airway epithelial cells.]
Neoplasms
[Relationship between sphingosine kinase 1 expression and tumor invasion, metastasis and prognosis in gastric cancer].
Neoplasms
[TNF-? regulates the proliferation of human breast cancer cells via regulation of ceramide content].
Neoplasms, Squamous Cell
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Nervous System Diseases
Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival.
Neuroblastoma
A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
Neuroblastoma
Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide.
Neuroblastoma
Lentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma.
Neuroblastoma
Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors.
Neuroblastoma
Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation.
Neuroblastoma
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
Neuroblastoma
Sphingosine Kinase 1/S1P Pathway Involvement in the GDNF-Induced GAP43 Transcription.
Neurodegenerative Diseases
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Neurodegenerative Diseases
Novelty of Sphingolipids in the Central Nervous System Physiology and Disease: Focusing on the Sphingolipid Hypothesis of Neuroinflammation and Neurodegeneration.
Neurodegenerative Diseases
Sphingosine kinase 1 could enhance stem cell therapy efficiency for neurodegenerative diseases through induction of HIF-1.
Neurodegenerative Diseases
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.
Neurodegenerative Diseases
Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease.
Neuroinflammatory Diseases
A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation.
Neuroinflammatory Diseases
Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
Neuroinflammatory Diseases
Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy.
Neuroinflammatory Diseases
Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
Neuroinflammatory Diseases
Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia.
Neuroinflammatory Diseases
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.
Neuroinflammatory Diseases
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-?B pathways in activated microglia in cerebral ischemia reperfusion.
Neutropenia
A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, peritonitis, and cytokine production in vivo.
Niemann-Pick Disease, Type C
Targeting defective sphingosine kinase 1 in Niemann-Pick type C disease with an activator mitigates cholesterol accumulation.
Non-alcoholic Fatty Liver Disease
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Generation of sphingosine-1-phosphate by sphingosine kinase 1 protects nonalcoholic fatty liver from ischemia/reperfusion injury through alleviating reactive oxygen species production in hepatocytes.
Non-alcoholic Fatty Liver Disease
Telmisartan and/or chlorogenic acid attenuates fructose-induced non-alcoholic fatty liver disease in rats: Implications of cross-talk between angiotensin, the sphingosine kinase/sphingoine-1-phosphate pathway, and TLR4 receptors.
Obesity
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
Obesity
K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.
Obesity
Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor ? in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity.
Obesity
Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance.
Optic Atrophy, Autosomal Dominant
Mitochondrial A-kinase anchoring proteins in cardiac ventricular myocytes.
Osteoarthritis
Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis.
Osteoarthritis
Experimental Osteoarthritis in Rats Is Attenuated by ABC294640, a Selective Inhibitor of Sphingosine Kinase-2.
Osteoarthritis
miRNA-103 promotes chondrocyte apoptosis by down-regulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis.
Osteosarcoma
Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro.
Osteosarcoma
Furowanin A Exhibits Antiproliferative and Pro-Apoptotic Activities by Targeting Sphingosine Kinase 1 in Osteosarcoma.
Osteosarcoma
Long Noncoding RNA MALAT1 Interacts with miR-124-3p to Modulate Osteosarcoma Progression by Targeting SphK1.
Osteosarcoma
MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1.
Osteosarcoma
MicroRNA-506-3p initiates mesenchymal-to-epithelial transition and suppresses autophagy in osteosarcoma cells by directly targeting SPHK1.
Osteosarcoma
Sphingosine kinase 1 contributes to doxorubicin resistance and glycolysis in osteosarcoma.
Osteosarcoma
The therapeutic value of the SphK1-targeting microRNA-3677 in human osteosarcoma cells.
Ovarian Neoplasms
CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1.
Ovarian Neoplasms
Exosomal transfer of miR-124 inhibits normal fibroblasts to cancer-associated fibroblasts transition by targeting sphingosine kinase 1 in ovarian cancer.
Ovarian Neoplasms
Follicle-stimulating hormone promotes the proliferation of epithelial ovarian cancer cells by activating sphingosine kinase.
Ovarian Neoplasms
MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1.
Ovarian Neoplasms
Sphingosine kinase 1 is required for TGF-? mediated fibroblastto- myofibroblast differentiation in ovarian cancer.
Ovarian Neoplasms
Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis.
Ovarian Neoplasms
Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo.
Ovarian Neoplasms
Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.
Ovarian Neoplasms
Sphingosine kinase-1 inhibition sensitizes curcumin-induced growth inhibition and apoptosis in ovarian cancer cells.
Ovarian Neoplasms
Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer.
Ovarian Neoplasms
Targeting Ovarian Cancer and Chemoresistance Through Selective Inhibition of Sphingosine Kinase-2 with ABC294640.
Pancreatic Neoplasms
Different Roles of Sphingosine Kinase 1 and 2 in Pancreatic Cancer Progression.
Pancreatic Neoplasms
Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-?B signaling.
Pancreatic Neoplasms
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Pancreatic Neoplasms
Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer.
Pancreatic Neoplasms
KAI1 inhibits HGF-induced invasion of pancreatic cancer by sphingosine kinase activity.
Pancreatic Neoplasms
Long Intergenic Nonprotein Coding RNA 173 Inhibits Tumor Growth and Promotes Apoptosis by Repressing Sphingosine Kinase 1 Protein Expression in Pancreatic Cancer.
Pancreatic Neoplasms
Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640.
Pancreatic Neoplasms
Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.
Parkinson Disease
Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase.
Parkinson Disease
Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease.
Parkinson Disease
Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP(+)-treated MN9D cells in vitro.
Periapical Periodontitis
SPHK1-S1PR1-RANKL Axis Regulates the Interactions Between Macrophages and BMSCs in Inflammatory Bone Loss.
Peritoneal Neoplasms
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Peritonitis
A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, peritonitis, and cytokine production in vivo.
Peritonitis
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice.
Peritonitis
Refining siRNA in vivo transfection: silencing SPHK1 reveals its key role in C5a-induced inflammation in vivo.
Pheochromocytoma
Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors.
Pheochromocytoma
Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation.
Pheochromocytoma
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.
Pheochromocytoma
Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12.
Pneumonia
Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and inflammation in mouse lung.
Pneumonia
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1.
Pneumonia
Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.
Pneumonia
Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness.
Pneumonia
S1P Generation by Sphingosine Kinase-2 in Recruited Macrophages Resolves Lung Inflammation by Blocking STING Signaling in Alveolar Macrophages.
Pneumonia
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.
Pneumonia, Pneumococcal
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.
Polycystic Kidney Diseases
Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.
Pregnancy, Ectopic
Aberrant sphingolipid metabolism in the human fallopian tube with ectopic pregnancy.
Premature Birth
Inhibition of sphingosine kinase prevents lipopolysaccharide-induced preterm birth and suppresses proinflammatory responses in a murine model.
Premature Birth
Sphingosine kinase: a novel putative target for the prevention of infection-triggered preterm birth.
Prostatic Neoplasms
Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase.
Prostatic Neoplasms
Anti-cancer effect of pristimerin by inhibition of HIF-1? involves the SPHK-1 pathway in hypoxic prostate cancer cells.
Prostatic Neoplasms
Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models.
Prostatic Neoplasms
Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.
Prostatic Neoplasms
Coumestrol suppresses hypoxia inducible factor 1? by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells.
Prostatic Neoplasms
Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.
Prostatic Neoplasms
Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1? and sphingosine kinase 1.
Prostatic Neoplasms
Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells.
Prostatic Neoplasms
First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.
Prostatic Neoplasms
FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
Prostatic Neoplasms
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Prostatic Neoplasms
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation.
Prostatic Neoplasms
Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.
Prostatic Neoplasms
Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival.
Prostatic Neoplasms
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.
Prostatic Neoplasms
Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel.
Prostatic Neoplasms
Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1? inactivation in hypoxic PC-3 prostate cancer cells.
Prostatic Neoplasms
Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens.
Prostatic Neoplasms
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models.
Prostatic Neoplasms
Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival.
Prostatic Neoplasms
Studies of hormonal regulation, phenotype plasticity, bone metastasis, and experimental therapeutics in androgen-repressed human prostate cancer (ARCaP) model.
Prostatic Neoplasms
Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.
Prostatic Neoplasms
The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.
Prostatic Neoplasms
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
Prostatic Neoplasms
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
Prostatic Neoplasms
The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.
Prostatic Neoplasms
Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer.
Proteinuria
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies.
Proteinuria
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Pseudolymphoma
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions.
Psoriasis
A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes.
Psoriasis
Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice.
Pulmonary Arterial Hypertension
Commentary: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Pulmonary Arterial Hypertension
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Pulmonary Arterial Hypertension
Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells.
Pulmonary Arterial Hypertension
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.
Pulmonary Arterial Hypertension
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-?B activation.
Pulmonary Arterial Hypertension
Targeting sphingosine kinase 1 for the treatment of pulmonary arterial hypertension.
Pulmonary Arterial Hypertension
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720.
Pulmonary Disease, Chronic Obstructive
Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.
Pulmonary Edema
Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe Plasmodium falciparum Malaria with Pulmonary Edema.
Pulmonary Fibrosis
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Pulmonary Fibrosis
Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.
Pulmonary Fibrosis
Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.
Pulmonary Fibrosis
Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis.
Pulmonary Fibrosis
The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes.
Renal Insufficiency, Chronic
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.
Reperfusion Injury
A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy.
Reperfusion Injury
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.
Reperfusion Injury
Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway.
Reperfusion Injury
Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways.
Reperfusion Injury
Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation.
Reperfusion Injury
Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury.
Reperfusion Injury
Sphingosine kinase 1 promotes cerebral ischemia-reperfusion injury through inducing ER stress and activating the NF-?B signaling pathway.
Reperfusion Injury
Sphingosine kinase 1 protects against renal ischemia-reperfusion injury in mice by sphingosine-1-phosphate(1) receptor activation.
Reperfusion Injury
The Role of Sphingomyelin Metabolism in the Protection of Rat Brain Microvascular Endothelial Cells by Mild Hypothermia.
Respiratory Distress Syndrome
Expression of sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 in malaria-associated acute lung injury/acute respiratory distress syndrome in a mouse model.
Retinal Degeneration
Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration.
Retinal Neovascularization
Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.
Rheumatic Diseases
Sphingosine kinase and sphingosine-1-phosphate receptors: novel therapeutic targets of rheumatoid arthritis?
Sandhoff Disease
Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.
Sepsis
Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication Mice.
Sepsis
Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis.
Sepsis
Inhibition of Sphingosine Kinase 1 Attenuates Sepsis-induced Microvascular Leakage via Inhibiting Macrophage NLRP3 Inflammasome Activation in Mice.
Sepsis
n-3 Polyunsaturated Fatty Acids Improve Inflammation via Inhibiting Sphingosine Kinase 1 in a Rat Model of Parenteral Nutrition and CLP-Induced Sepsis.
Sepsis
Preclinical evidence of sphingosine kinase 1 inhibition in alleviation of intestinal epithelial injury in polymicrobial sepsis.
Sepsis
SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.
Shock, Septic
SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.
Skin Diseases
Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice.
Small Cell Lung Carcinoma
[Role of SPHK1 regulates multi-drug resistance of small cell lung cancer ?and its clinical significance].
sphingosine kinase deficiency
Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.
sphingosine kinase deficiency
Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPAR?.
sphingosine kinase deficiency
Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.
sphingosine kinase deficiency
Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model.
sphingosine kinase deficiency
Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.
sphingosine kinase deficiency
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
sphingosine kinase deficiency
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
sphingosine kinase deficiency
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
sphingosine kinase deficiency
Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signalling in macrophages.
sphingosine kinase deficiency
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
sphingosine kinase deficiency
Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness.
sphingosine kinase deficiency
Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model: Role of S1P Signaling and Nox Proteins.
sphingosine kinase deficiency
Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
sphingosine kinase deficiency
Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-?.
sphingosine kinase deficiency
Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts.
sphingosine kinase deficiency
Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication.
sphingosine kinase deficiency
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.
sphingosine kinase deficiency
SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition.
sphingosine kinase deficiency
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.
sphingosine kinase deficiency
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
sphingosine kinase deficiency
TRAF2 regulates TNF and NF-?B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.
Spinal Cord Injuries
Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
A role of sphingosine kinase 1 in head and neck carcinogenesis.
Squamous Cell Carcinoma of Head and Neck
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
Squamous Cell Carcinoma of Head and Neck
Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Enhancement of SPHK1 in vitro by carbon ion irradiation in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Gold nanorod-sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Squamous Cell Carcinoma of Head and Neck
Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
Squamous Cell Carcinoma of Head and Neck
MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
Squamous Cell Carcinoma of Head and Neck
Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
The expression of sphingosine kinase-1 in head and neck carcinoma.
Squamous Cell Carcinoma of Head and Neck
The impact of sphingosine kinase-1 in head and neck cancer.
Starvation
Endothelin-1 inhibits apoptosis through a sphingosine kinase 1-dependent mechanism in uterine leiomyoma ELT3 cells.
Starvation
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.
Starvation
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation.
Starvation
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.
Stomach Neoplasms
A sphingosine kinase-1 inhibitor, SKI-II, induces growth inhibition and apoptosis in human gastric cancer cells.
Stomach Neoplasms
Alphastatin downregulates vascular endothelial cells sphingosine kinase activity and suppresses tumor growth in nude mice bearing human gastric cancer xenografts.
Stomach Neoplasms
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Stomach Neoplasms
Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer.
Stomach Neoplasms
Functional Genetic Variants in SPHK1 Affect Susceptibility to Gastric Cancer in a Chinese Population.
Stomach Neoplasms
Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.
Stomach Neoplasms
METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2.
Stomach Neoplasms
miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1.
Stomach Neoplasms
Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.
Stomach Neoplasms
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients.
Stomach Neoplasms
SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling.
Stomach Neoplasms
Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.
Stomach Neoplasms
[Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro].
Stomach Neoplasms
[Relationship between sphingosine kinase 1 expression and tumor invasion, metastasis and prognosis in gastric cancer].
Stroke
Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.
Stroke
Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway.
Stroke
Junctional protein regulation by sphingosine kinase 2 contributes to blood-brain barrier protection in hypoxic preconditioning-induced cerebral ischemic tolerance.
Subarachnoid Hemorrhage
Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice.
Subarachnoid Hemorrhage
Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage.
Synovitis
Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720.
Synovitis
Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses.
Synovitis
Sphingosine kinase and sphingosine-1-phosphate receptors: novel therapeutic targets of rheumatoid arthritis?
Teratocarcinoma
A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry.
Thrombocytopenia
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
Thrombocytopenia
Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes.
Thrombocytopenia
Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P).
Thrombosis
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
Thrombosis
Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formation.
Thrombosis
The impact of sphingosine kinase 1 on the prognosis of hepatocellular carcinoma patients with portal vein tumor thrombus.
Thyroid Cancer, Papillary
Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer.
Thyroid Cancer, Papillary
Long noncoding RNA LINC00520 accelerates progression of papillary thyroid carcinoma by serving as a competing endogenous RNA of microRNA-577 to increase Sphk2 expression.
Thyroid Cancer, Papillary
MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2.
Thyroid Cancer, Papillary
MiR-577 inhibits papillary thyroid carcinoma cell proliferation, migration and invasion by targeting SphK2.
Thyroid Cancer, Papillary
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Thyroid Cancer, Papillary
Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.
Thyroid Neoplasms
Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer.
Thyroid Neoplasms
MiR-128 suppresses the growth of thyroid carcinoma by negatively regulating SPHK1.
Thyroid Neoplasms
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Thyroid Neoplasms
Sphingosine kinase 1 is overexpressed and promotes proliferation in human thyroid cancer.
Thyroid Neoplasms
Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2.
Thyroid Neoplasms
SPHK1 promotes metastasis of thyroid carcinoma through activation of the S1P/S1PR3/Notch signaling pathway.
Triple Negative Breast Neoplasms
Inhibition of insulin-like growth factor-binding protein-3 signaling through sphingosine kinase-1 sensitizes triple-negative breast cancer cells to EGF receptor blockade.
Triple Negative Breast Neoplasms
Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway.
Triple Negative Breast Neoplasms
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate.
Triple Negative Breast Neoplasms
Sphingosine kinase 1 activation by estrogen receptor ?36 contributes to tamoxifen resistance in breast cancer.
Triple Negative Breast Neoplasms
Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.
Triple Negative Breast Neoplasms
SPHK1 regulates proliferation and survival responses in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
Trypanosomiasis, African
Sphingosine Kinase Regulates Microtubule Dynamics and Organelle Positioning Necessary for Proper G1/S Cell Cycle Transition in Trypanosoma brucei.
Tuberculosis
Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase.
Tuberculosis
Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase.
Tuberculosis
Sphingolipids Are Dual Specific Drug Targets for the Management of Pulmonary Infections: Perspective.
Tuberculosis
Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis.
Tuberculosis
Tuberculosis lymph node granulomas: using transcriptomics to discover immunopathology paradigms and guide host-directed therapy.
Tuberculosis, Lymph Node
Tuberculosis lymph node granulomas: using transcriptomics to discover immunopathology paradigms and guide host-directed therapy.
Ureteral Obstruction
Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction.
Ureteral Obstruction
Knockout of Sphingosine Kinase 1 Attenuates Renal Fibrosis in Unilateral Ureteral Obstruction Model.
Ureteral Obstruction
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.
Urethral Obstruction
Tumor necrosis factor superfamily 14 is critical for the development of renal fibrosis.
Urinary Bladder Neoplasms
Increased SPHK1 expression is associated with poor prognosis in bladder cancer.
Urinary Bladder Neoplasms
miR-613 inhibits bladder cancer proliferation and migration through targeting SphK1.
Urinary Bladder Neoplasms
MiRNA-125b inhibits proliferation and migration by targeting SphK1 in bladder cancer.
Uterine Cervical Neoplasms
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.
Vascular System Injuries
Differential regulation of sphingosine kinases 1 and 2 in lung injury.
Virus Diseases
In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection.
Virus Diseases
Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection.
Virus Diseases
Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses.
Virus Diseases
Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.
Virus Diseases
Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.
Virus Diseases
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.
Virus Diseases
Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus.
Virus Diseases
Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro.
Whooping Cough
Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms.
Whooping Cough
Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms.
Whooping Cough
Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein ?? subunit-dependent pathway in rat cerebrocortical nerve terminals.
Whooping Cough
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation.
Whooping Cough
Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes.
Whooping Cough
Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation.
Whooping Cough
The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.
Whooping Cough
The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator.
Wilms Tumor
A novel sphingosine kinase 1 inhibitor (SKI-5C) induces cell death of Wilms' tumor cells
Wilms Tumor
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
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SOURCE
Klawitter, S.; Hofmann, L.P.; Pfeilschifter, J.; Huwiler, A.
Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity
Br. J. Pharmacol.
150
271-280
2007
Rattus norvegicus (Q6AYB2), Rattus norvegicus (Q91V26)
brenda
Vessey, D.A.; Kelley, M.; Zhang, J.; Li, L.; Tao, R.; Karliner, J.S.
Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart
J. Biochem. Mol. Toxicol.
21
273-279
2007
Rattus norvegicus (Q6AYB2), Rattus norvegicus (Q91V26)
brenda
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