Reference on EC 2.7.1.68 - 1-phosphatidylinositol-4-phosphate 5-kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Moritz, A.; Westerman, J.; De Graan, P.N.E.; Wirtz, K.W.A.
Phosphatidylinositol 4-kinase and phosphatidylinositol-4-phosphate 5-kinase from bovine brain membranes
Methods Enzymol.
209
202-211
1992
Bos taurus
Sommarin, M.; Sandelius, A.S.
Phosphatidylinositol and phosphatidylinositolphosphate kinases in plant plasma membranes
Biochim. Biophys. Acta
958
268-278
1988
Triticum aestivum
-
Cooper, P.H.; Hawthorne, J.N.
Phosphatidylinositol kinase and diphosphoinositide kinase of rat kidney cortex: properties and subcellular localization
Biochem. J.
160
97-105
1976
Rattus norvegicus
Kai, M.; Salway, J.G.; Hawthorne, J.N.
The diphosphoinositide kinase of rat brain
Biochem. J.
106
791-801
1968
Rattus norvegicus
Moritz, A.; De Graan, P.N.E.; Ekhart, P.F.; Gispen, W.H.; Wirtz, K.W.A.
Purification of a phosphatidylinositol 4-phosphate kinase from bovine brain membranes
J. Neurochem.
54
351-354
1990
Bos taurus
Smith, P.M.; Wreggett, K.A.; Irvine, R.F.
The phosphatidylinositol 4-phosphate kinase of rat brain and human platelets
Biochem. Soc. Trans.
14
1145-1146
1986
Homo sapiens, Rattus norvegicus
-
Bazenet, C.E.; Anderson, R.A.
Phosphatidylinositol-4-phosphate 5-kinases from human erythrocytes
Methods Enzymol.
209
189-202
1992
Homo sapiens
Van Rooijen, L.A.A.; Rossowska, M.; Bazan, N.G.
Inhibition of phosphatidylinositol-4-phosphate kinase by its product phosphatidylinositol-4,5-bisphosphate
Biochem. Biophys. Res. Commun.
126
150-155
1985
Bos taurus
Kato, H.; Uno, I.; Ishikawa, T.; Takenawa, T.
Activation of phosphatidylinositol kinase and phosphatidylinositol-4-phosphate kinase by cAMP in Saccharomyces cerevisiae
J. Biol. Chem.
264
3116-3121
1989
Saccharomyces cerevisiae
Lundberg, G.A.; Sundler, R.; Jergil, B.
Activation of phosphatidylinositol-4-phosphate kinase in rat liver plasma membranes by polyamines
Biochim. Biophys. Acta
922
1-7
1987
Rattus norvegicus
Cochet, C.; Chambaz, E.M.
Catalytic properties of a purified phosphatidylinositol-4-phosphate kinase from rat brain
Biochem. J.
237
25-31
1986
Rattus norvegicus
Lundberg, G.A.; Jergil, B.; Sundler, R.
Phosphatidylinositol-4-phosphate kinase from rat brain. Activation by polyamines and inhibition by phosphatidylinositol 4,5-bisphosphate
Eur. J. Biochem.
161
257-262
1986
Rattus norvegicus
Urumow, T.; Wieland, O.H.
Purification and partial characterization of phosphatidylinositol-4-phosphate kinase from rat liver plasma membranes. Further evidence for a stimulatory G-protein
Biochim. Biophys. Acta
1052
152-158
1990
Rattus norvegicus
Husebye, E.S.; Flatmark, T.
Purification and kinetic properties of a soluble phosphatidylinositol-4-phosphate kinase of the bovine adrenal medulla with emphasis on its inhibition by calcium ions
Biochim. Biophys. Acta
1010
250-257
1989
Bos taurus
Van Dongen, C.J.; Zwiers, H.; Gispen, W.H.
Purification and partial characterization of the phosphatidylinositol 4-phosphate kinase from rat brain
Biochem. J.
223
197-203
1984
Rattus norvegicus
Ling, L.E.; Schulz, J.T.; Cantley, L.C.
Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells
J. Biol. Chem.
264
5080-5088
1989
Homo sapiens
Moritz, A.; De Graan, P.N.E.; Gispen, W.H.; Wirtz, K.W.A.
Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase
J. Biol. Chem.
267
7207-7210
1992
Bos taurus
Galiano, F.J.; Ulug, E.T.; Davis, J.N.
Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Ibeta disrupts a phosphatidylinositol 4,5 bisphosphate regulated endosomal pathway
J. Cell. Biochem.
85
131-145
2002
Mus musculus
Zhang, X.; Loijens, J.C.; Boronenkov, I.V.; Parker, G.J.; Norris, F.A.; Chen, J.; Thum, O.; Prestwich, G.D.; Majerus, P.W.; Anderson, R.A.
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules
J. Biol. Chem.
272
17756-17761
1997
Homo sapiens
Cutler, N.S.; Heitman, J.; Cardenas, M.E.
STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae
J. Biol. Chem.
272
27671-27677
1997
Saccharomyces cerevisiae
Loijens, J.C.; Anderson, R.A.
Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family
J. Biol. Chem.
271
32937-32943
1996
Bos taurus
Homma, K.; Terui, S.; Minemura, M.; Qadota, H.; Anraku, Y.; Kanaho, Y.; Ohya, Y.
Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis
J. Biol. Chem.
273
15779-15786
1998
Saccharomyces cerevisiae
Vancurova, I.; Choi, J.H.; Lin, H.; Kuret, J.; Vancura, A.
Regulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I
J. Biol. Chem.
274
1147-1155
1999
Schizosaccharomyces pombe
Mikami, K.; Katagiri, T.; Iuchi, S.; Yamaguchi-Shinozaki, K.; Shinozaki, K.
A gene encoding phosphatidylinositol-4-phosphate 5-kinase is induced by water stress and abscisic acid in Arabidopsis thaliana
Plant J.
15
563-568
1998
Arabidopsis thaliana
Barbieri, M.A.; Heath, C.M.; Peters, E.M.; Wells, A.; Davis, J.N.; Stahl, P.D.
Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis
J. Biol. Chem.
276
47212-47216
2001
Mus musculus
Coppolino, M.G.; Dierckman, R.; Loijens, J.; Collins, R.F.; Pouladi, M.; Jongstra-Bilen, J.; Schreiber, A.D.; Trimble, W.S.; Anderson, R.; Grinstein, S.
Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis
J. Biol. Chem.
277
43849-43857
2002
Mus musculus
Yamazaki, M.; Miyazaki, H.; Watanabe, H.; Sasaki, T.; Maehama, T.; Frohman, M.A.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling
J. Biol. Chem.
277
17226-17230
2002
Mus musculus
Kwok, F.; Humpage, A.; Cheng, C.H.K.
Phosphatidylinositol phosphate 5-kinase: purification and inhibition studies
Prep. Biochem. Biotechnol.
26
1-19
1996
Ovis aries
Jones, D.H.; Morris, J.B.; Morgan, C.P.; Kondo, H.; Irvine, R.F.; Cockcroft, S.
Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment
J. Biol. Chem.
275
13962-13966
2000
Rattus norvegicus
Hairfield, M.L.; Westwater, C.; Dolan, J.W.
Phosphatidylinositol-4-phosphate 5-kinase activity is stimulated during temperature-induced morphogenesis in Candida albicans
Microbiology
148
1737-1746
2002
Candida albicans
Wenk, M.R.; Pellegrini, L.; Klenchin, V.A.; Di Paolo, G.; Chang, S.; Daniell, L.; Arioka, M.; Martin, T.F.; De Camilli, P.
PIP kinase Ig is the major PI(4,5)P2 synthesizing enzyme at the synapse
Neuron
32
79-88
2001
Rattus norvegicus
Tolias, K.F.; Hartwig, J.H.; Ishihara, H.; Shibasaki, Y.; Cantley, L.C.; Carpenter, C.L.
Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
Curr. Biol.
10
153-156
2000
Mus musculus
Oude Weernink, P.A.; Schulte, P.; Guo, Y.; Wetzel, J.; Amano, M.; Kaibuchi, K.; Haverland, S.; Voss, M.; Schmidt, M.; Mayr, G.W.; Jakobs, K.H.
Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase
J. Biol. Chem.
275
10168-10174
2000
Homo sapiens
Park, S.J.; Itoh, T.; Takenawa, T.
Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli
J. Biol. Chem.
276
4781-4787
2001
Mus musculus
van Horck, F.P.; Lavazais, E.; Eickholt, B.J.; Moolenaar, W.H.; Divecha, N.
Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling
Curr. Biol.
12
241-245
2002
Mus musculus
Kanaho, Y.; Miyazaki, H.; Yamazaki, M.
Activation of PI(4)P 5-kinase by small G proteins
Adv. Enzyme Regul.
43
107-119
2003
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Arioka, M.; Nakashima, S.; Shibasaki, Y.; Kitamoto, K.
Dibasic amino acid residues at the carboxy-terminal end of kinase homology domain participate in the plasma membrane localization and function of phosphatidylinositol 5-kinase gamma
Biochem. Biophys. Res. Commun.
319
456-463
2004
Mus musculus
Giudici, M.L.; Emson, P.C.; Irvine, R.F.
A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma
Biochem. J.
379
489-496
2004
Rattus norvegicus
Oude Weernink, P.A.; Schmidt, M.; Jakobs, K.H.
Regulation and cellular roles of phosphoinositide 5-kinases
Eur. J. Pharmacol.
500
87-99
2004
Saccharomyces cerevisiae, Candida albicans, Homo sapiens, Mus musculus, Schizosaccharomyces pombe
Perera, I.Y.; Davis, A.J.; Galanopoulou, D.; Im, Y.J.; Boss, W.F.
Characterization and comparative analysis of Arabidopsis phosphatidylinositol phosphate 5-kinase 10 reveals differences in Arabidopsis and human phosphatidylinositol phosphate kinases
FEBS Lett.
579
3427-3432
2005
Arabidopsis thaliana (Q56YP2), Arabidopsis thaliana (Q9LMN1), Homo sapiens (Q99755), Homo sapiens
Padron, D.; Wang, Y.J.; Yamamoto, M.; Yin, H.; Roth, M.G.
Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis
J. Cell Biol.
162
693-701
2003
Mus musculus
Wong, K.W.; Isberg, R.R.
Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake
J. Exp. Med.
198
603-614
2003
Mus musculus
Perez-Mansilla, B.; Ha, V.L.; Justin, N.; Wilkins, A.J.; Carpenter, C.L.; Thomas, G.M.
The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6
Biochim. Biophys. Acta
1761
1429-1442
2006
Mus musculus
Akiyama, C.; Shinozaki-Narikawa, N.; Kitazawa, T.; Hamakubo, T.; Kodama, T.; Shibasaki, Y.
Phosphatidylinositol-4-phosphate 5-kinase gamma is associated with cell-cell junction in A431 epithelial cells
Cell Biol. Int.
29
514-520
2005
Homo sapiens
Halstead, J.R.; van Rheenen, J.; Snel, M.H.; Meeuws, S.; Mohammed, S.; DSantos, C.S.; Heck, A.J.; Jalink, K.; Divecha, N.
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis
Curr. Biol.
16
1850-1856
2006
Homo sapiens, Mus musculus
Nakano-Kobayashi, A.; Yamazaki, M.; Unoki, T.; Hongu, T.; Murata, C.; Taguchi, R.; Katada, T.; Frohman, M.A.; Yokozeki, T.; Kanaho, Y.
Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis
EMBO J.
26
1105-1116
2007
Mus musculus
Xu, X.; Guo, H.; Wycuff, D.L.; Lee, M.
Role of phosphatidylinositol-4-phosphate 5 kinase (ppk-1) in ovulation of Caenorhabditis elegans
Exp. Cell Res.
313
2465-2475
2007
Caenorhabditis elegans
Giudici, M.L.; Lee, K.; Lim, R.; Irvine, R.F.
The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants
FEBS Lett.
580
6933-6937
2006
Mus musculus
Cabezas, A.; Pattni, K.; Stenmark, H.
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
Gene
371
34-41
2006
Homo sapiens (Q9Y2I7)
Ling, K.H.; Loo, S.S.; Rosli, R.; Shamsudin, M.N.; Mohamed, R.; Wan, K.L.
In silico identification and characterization of a putative phosphatidylinositol 4-phosphate 5-kinase (PIP5K) gene in Eimeria tenella
In Silico Biol.
7
115-121
2007
Eimeria tenella (A1YQB1), Eimeria tenella
Kobayashi, T.; Takematsu, H.; Yamaji, T.; Hiramoto, S.; Kozutsumi, Y.
Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast
J. Biol. Chem.
280
18087-18094
2005
Saccharomyces cerevisiae
Deng, L.; Sugiura, R.; Ohta, K.; Tada, K.; Suzuki, M.; Hirata, M.; Nakamura, S.; Shuntoh, H.; Kuno, T.
Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway
J. Biol. Chem.
280
27561-27568
2005
Schizosaccharomyces pombe
Powner, D.J.; Payne, R.M.; Pettitt, T.R.; Giudici, M.L.; Irvine, R.F.; Wakelam, M.J.
Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b
J. Cell Sci.
118
2975-2986
2005
Rattus norvegicus
Jarquin-Pardo, M.; Fitzpatrick, A.; Galiano, F.J.; First, E.A.; Davis, J.N.
Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate
J. Cell. Biochem.
100
112-128
2007
Mus musculus
Kisseleva, M.; Feng, Y.; Ward, M.; Song, C.; Anderson, R.A.; Longmore, G.D.
The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha
Mol. Cell. Biol.
25
3956-3966
2005
Homo sapiens
Lou, Y.; Gou, J.Y.; Xue, H.W.
PIP5K9, an Arabidopsis phosphatidylinositol monophosphate kinase, interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth
Plant Cell
19
163-181
2007
Arabidopsis thaliana (Q8L850), Arabidopsis thaliana
Gong, L.W.; Di Paolo, G.; Diaz, E.; Cestra, G.; Diaz, M.E.; Lindau, M.; De Camilli, P.; Toomre, D.
Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion
Proc. Natl. Acad. Sci. USA
102
5204-5209
2005
Mus musculus
Krauss, M.; Kukhtina, V.; Pechstein, A.; Haucke, V.
Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes
Proc. Natl. Acad. Sci. USA
103
11934-11939
2006
Rattus norvegicus
Kusano, H.; Testerink, C.; Vermeer, J.E.; Tsuge, T.; Shimada, H.; Oka, A.; Munnik, T.; Aoyama, T.
The arabidopsis phosphatidylinositol phosphate 5-kinase PIP5K3 is a key regulator of root hair tip growth
Plant Cell
20
367-380
2008
Arabidopsis thaliana (O48709), Arabidopsis thaliana
Weinkove, D.; Bastiani, M.; Chessa, T.A.; Joshi, D.; Hauth, L.; Cooke, F.T.; Divecha, N.; Schuske, K.
Overexpression of PPK-1, the Caenorhabditis elegans type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults
Dev. Biol.
313
384-397
2008
Caenorhabditis elegans (O01759), Caenorhabditis elegans
Weixel, K.M.; Edinger, R.S.; Kester, L.; Guerriero, C.J.; Wang, H.; Fang, L.; Kleyman, T.R.; Welling, P.A.; Weisz, O.A.; Johnson, J.P.
Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells
J. Biol. Chem.
282
36534-36542
2007
Mus musculus
Nelson, C.D.; Kovacs, J.J.; Nobles, K.N.; Whalen, E.J.; Lefkowitz, R.J.
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor
J. Biol. Chem.
283
21093-21101
2008
Homo sapiens
Lacalle, R.A.; Peregil, R.M.; Albar, J.P.; Merino, E.; Martinez-A, C.; Merida, I.; Manes, S.
Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement
J. Cell Biol.
179
1539-1553
2007
Homo sapiens
Lokuta, M.A.; Senetar, M.A.; Bennin, D.A.; Nuzzi, P.A.; Chan, K.T.; Ott, V.L.; Huttenlocher, A.
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis
Mol. Biol. Cell
18
5069-5080
2007
Homo sapiens, Mus musculus
Stenzel, I.; Ischebeck, T.; Koenig, S.; Ho?ubowska, A.; Sporysz, M.; Hause, B.; Heilmann, I.
The type B phosphatidylinositol-4-phosphate 5-kinase 3 is essential for root hair formation in Arabidopsis thaliana
Plant Cell
20
124-141
2008
Arabidopsis thaliana
Xia, Y.; Irvine, R.F.; Giudici, M.L.
Phosphatidylinositol 4-phosphate 5-kinase Igamma_v6, a new splice variant found in rodents and humans
Biochem. Biophys. Res. Commun.
411
416-420
2011
Homo sapiens, Mus musculus, Rattus norvegicus
Gallicchio, M.A.; Bach, L.A.
Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: role of cytosolic phospholipase A2alpha and phosphatidylinositol 4-phosphate 5-kinase gamma
Biochim. Biophys. Acta
1803
919-930
2010
Homo sapiens, Sus scrofa
Hasegawa, H.; Noguchi, J.; Yamashita, M.; Okada, R.; Sugimoto, R.; Furuya, M.; Unoki, T.; Funakoshi, Y.; Baba, T.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis
Biol. Reprod.
86:136
1-12
2012
Mus musculus
Sakurai, A.; Jian, X.; Lee, C.J.; Manavski, Y.; Chavakis, E.; Donaldson, J.; Randazzo, P.A.; Gutkind, J.S.
Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein
J. Biol. Chem.
286
34335-34345
2011
Homo sapiens
Shulga, Y.V.; Anderson, R.A.; Topham, M.K.; Epand, R.M.
Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator
J. Biol. Chem.
287
35953-35963
2012
Mus musculus
Nguyen, T.T.; Kim, Y.M.; Kim, T.D.; Le, O.T.; Kim, J.J.; Kang, H.C.; Hasegawa, H.; Kanaho, Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location
J. Biol. Chem.
288
5645-5659
2013
Homo sapiens, Mus musculus (P70182)
Goh, M.Y.; Pan, M.Z.; Blake, D.P.; Wan, K.L.; Song, B.K.
Eimeria maxima phosphatidylinositol 4-phosphate 5-kinase: locus sequencing, characterization, and cross-phylum comparison
Parasitol. Res.
108
611-620
2011
Eimeria maxima (C8BX38), Eimeria maxima, Eimeria maxima Weybridge (C8BX38)
Noda, Y.; Niwa, S.; Homma, N.; Fukuda, H.; Imajo-Ohmi, S.; Hirokawa, N.
Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKalpha) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches
Proc. Natl. Acad. Sci. USA
109
1725-1730
2012
Mus musculus
Sakagami, H.; Katsumata, O.; Hara, Y.; Tamaki, H.; Fukaya, M.
Preferential localization of type I phosphatidylinositol 4-phosphate 5-kinase gamma at the periactive zone of mouse photoreceptor ribbon synapses
Brain Res.
1586
23-33
2014
Mus musculus
Sun, Y.; Hedman, A.C.; Tan, X.; Schill, N.J.; Anderson, R.A.
Endosomal type Igamma PIP 5-kinase controls EGF receptor lysosomal sorting
Dev. Cell
25
144-155
2013
Homo sapiens
Choi, S.; Thapa, N.; Hedman, A.C.; Li, Z.; Sacks, D.B.; Anderson, R.A.
IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration
EMBO J.
32
2617-2630
2013
Homo sapiens (O60331)
Hara, Y.; Fukaya, M.; Tamaki, H.; Sakagami, H.
Type I phosphatidylinositol 4-phosphate 5-kinase gamma is required for neuronal migration in the mouse developing cerebral cortex
Eur. J. Neurosci.
38
2659-2671
2013
Mus musculus
Liu, T.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells
Exp. Mol. Med.
45
e16
2013
Rattus norvegicus
Lacalle, R.A.; de Karam, J.C.; Martinez-Munoz, L.; Artetxe, I.; Peregil, R.M.; Sot, J.; Rojas, A.M.; Goni, F.M.; Mellado, M.; Manes, S.
Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity
FASEB J.
29
2371-2385
2015
Homo sapiens
Porciello, N.; Kunkl, M.; Viola, A.; Tuosto, L.
Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation
Front. Immunol.
7
186
2016
Homo sapiens
Thapa, N.; Choi, S.; Hedman, A.; Tan, X.; Anderson, R.A.
Phosphatidylinositol phosphate 5-kinase Igammai2 in association with Src controls anchorage-independent growth of tumor cells
J. Biol. Chem.
288
34707-34718
2013
Homo sapiens
Thapa, N.; Choi, S.; Tan, X.; Wise, T.; Anderson, R.A.
Phosphatidylinositol phosphate 5-kinase Igamma and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth
J. Biol. Chem.
290
18843-18854
2015
Homo sapiens
Chakrabarti, R.; Sanyal, S.; Ghosh, A.; Bhar, K.; Das, C.; Siddhanta, A.
Phosphatidylinositol-4-phosphate 5-kinase 1alpha modulates ribosomal RNA gene silencing through its interaction with histone H3 lysine 9 trimethylation and heterochromatin protein HP1-alpha
J. Biol. Chem.
290
20893-20903
2015
Homo sapiens (Q99755)
Muscolini, M.; Camperio, C.; Capuano, C.; Caristi, S.; Piccolella, E.; Galandrini, R.; Tuosto, L.
Phosphatidylinositol 4-phosphate 5-kinase alpha activation critically contributes to CD28-dependent signaling responses
J. Immunol.
190
5279-5286
2013
Homo sapiens
Muscolini, M.; Camperio, C.; Porciello, N.; Caristi, S.; Capuano, C.; Viola, A.; Galandrini, R.; Tuosto, L.
Phosphatidylinositol 4-phosphate 5-kinase alpha and Vav1 mutual cooperation in CD28-mediated actin remodeling and signaling functions
J. Immunol.
194
1323-1333
2015
Homo sapiens
Kallikourdis, M.; Trovato, A.E.; Roselli, G.; Muscolini, M.; Porciello, N.; Tuosto, L.; Viola, A.
Phosphatidylinositol 4-phosphate 5-kinase beta controls recruitment of lipid rafts into the immunological synapse
J. Immunol.
196
1955-1963
2016
Homo sapiens
Kubo, T.; Ding, W.G.; Toyoda, F.; Fujii, Y.; Omatsu-Kanbe, M.; Matsuura, H.
Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation
J. Pharmacol. Sci.
127
127-134
2015
Homo sapiens
Yamazaki, M.; Yamauchi, Y.; Goshima, Y.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase beta regulates growth cone morphology and semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons
Neurosci. Lett.
547
59-64
2013
Mus musculus
Wada, Y.; Kusano, H.; Tsuge, T.; Aoyama, T.
Phosphatidylinositol phosphate 5-kinase genes respond to phosphate deficiency for root hair elongation in Arabidopsis thaliana
Plant J.
81
426-437
2015
Arabidopsis thaliana
Ugalde, J.M.; Rodriguez-Furlan, C.; Rycke, R.D.; Norambuena, L.; Friml, J.; Leon, G.; Tejos, R.
Phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole morphology during Arabidopsis thaliana pollen development
Plant Sci.
250
10-19
2016
Arabidopsis thaliana
Nguyen, T.T.N.; Seo, E.; Choi, J.; Le, O.T.T.; Kim, J.Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid
Cell. Signal.
38
159-170
2017
Mus musculus
Wu, P.F.; Bhore, N.; Lee, Y.L.; Chou, J.Y.; Chen, Y.W.; Wu, P.Y.; Hsu, W.M.; Lee, H.; Huang, Y.S.; Lu, P.J.; Liao, Y.F.
Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein
FASEB J.
34
12127-12146
2020
Homo sapiens
Sharma, S.; Bhattacharya, S.; Bhattacharya, A.
PtdIns(4,5)P2 is generated by a novel phosphatidylinositol 4-phosphate 5-kinase in the protist parasite Entamoeba histolytica
FEBS J.
286
2216-2234
2019
Entamoeba histolytica (C4LSF7), Entamoeba histolytica HM1:IMSS (C4LSF7)
Khrongyut, S.; Rawangwong, A.; Pidsaya, A.; Sakagami, H.; Kondo, H.; Hipkaeo, W.
Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) alpha, beta, gamma in the three major salivary glands in situ of mice and their response to beta-adrenoceptor stimulation
J. Anat.
234
502-514
2019
Mus musculus (O70161), Mus musculus (P70181), Mus musculus (P70182)
Sun, M.; Cai, J.; Anderson, R.A.; Sun, Y.
Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls the ubiquitination and degradation of the tumor suppressor mitogen-inducible gene 6
J. Biol. Chem.
291
21461-21473
2016
Homo sapiens
De La Cruz, L.; Traynor-Kaplan, A.; Vivas, O.; Hille, B.; Jensen, J.
Plasma membrane processes are differentially regulated by type I phosphatidylinositol phosphate 5-kinases and RASSF4
J. Cell Sci.
133
jcs233254
2020
Homo sapiens (O14986), Homo sapiens (O60331)
Gonzales, B.; de Rocquigny, H.; Beziau, A.; Durand, S.; Burlaud-Gaillard, J.; Lefebvre, A.; Krull, S.; Emond, P.; Brand, D.; Piver, E.
Type I phosphatidylinositol-4-phosphate 5-kinases alpha and gamma play a key role in targeting HIV-1 Pr55Gag to the plasma membrane
J. Virol.
94
e00189-20
2020
Homo sapiens (O60331), Homo sapiens (Q99755)
Gerth, K.; Lin, F.; Daamen, F.; Menzel, W.; Heinrich, F.; Heilmann, M.
Arabidopsis phosphatidylinositol 4-phosphate 5-kinase 2 contains a functional nuclear localization sequence and interacts with alpha-importins
Plant J.
92
862-878
2017
Arabidopsis thaliana
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