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ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ATP + phosphatidylinositol 3-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
-
-
-
?
ATP + phosphatidylinsositol 3,4-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
-
-
-
?
GTP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
GDP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
0.05 mM GTP is 2fold more active than ATP with type II enzyme. 0.05 mM GTP is 5fold more active than ATP with the type I enzyme
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?
additional information
?
-
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
641824, 641825, 641834, 641840, 660641, 661660, 672961, 673185, 675959, 721706, 722723, 738090, 738199, 738288, 738599, 738651, 738787, 738790, 738794, 738912, 759168, 759475, 760179 -
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
Rho-kinase is involved in the Rho-controlled synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate by phosphatidylinositol-4-phosphate 5-kinase
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
additional information
?
-
-
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
beta-arrestins direct the localization of phosphatidylinositol 4-phosphate 5-kinase 1alpha and phosphatidylinositol 4,5-bisphosphate production to agonist-activated 7-transmembrane receptors, thereby regulating receptor internalization
-
-
?
additional information
?
-
-
phosphatidylinositol 4-phosphate 5-kinase beta is involved in polarization at the uropod of neutrophil-differentiated HL60 cells. Phosphatidylinositol 4-phosphate 5-kinase beta localization is independent of its lipid kinase activity, but requires the 83 C-terminal amino acids. The C-terminus interacts with 4.1-ezrin-radixin-moesin-binding phosphoprotein 50, which enables further interactions with ezrin-radixin-moesin proteins and the Rho-GDP dissociation inhibitor
-
-
?
additional information
?
-
-
endosome-bound phosphatidylinositol 4-phosphate 5-kinase homolog PIP5K-like 1 recruits phosphatidylinositol 4-phosphate 5-kinases to intracellular compartments and interacts with them in cells
-
-
-
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ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
additional information
?
-
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
721706, 722723, 738090, 738199, 738288, 738599, 738651, 738787, 738790, 738794, 738912, 759168, 759475, 760179 -
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
Rho-kinase is involved in the Rho-controlled synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate by phosphatidylinositol-4-phosphate 5-kinase
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
additional information
?
-
-
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
additional information
?
-
-
beta-arrestins direct the localization of phosphatidylinositol 4-phosphate 5-kinase 1alpha and phosphatidylinositol 4,5-bisphosphate production to agonist-activated 7-transmembrane receptors, thereby regulating receptor internalization
-
-
?
additional information
?
-
-
phosphatidylinositol 4-phosphate 5-kinase beta is involved in polarization at the uropod of neutrophil-differentiated HL60 cells. Phosphatidylinositol 4-phosphate 5-kinase beta localization is independent of its lipid kinase activity, but requires the 83 C-terminal amino acids. The C-terminus interacts with 4.1-ezrin-radixin-moesin-binding phosphoprotein 50, which enables further interactions with ezrin-radixin-moesin proteins and the Rho-GDP dissociation inhibitor
-
-
?
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Alzheimer Disease
Phosphatidylinositol kinase is reduced in Alzheimer's disease.
Anaphylaxis
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.
Anaphylaxis
[Compartmentalization of phosphatidylinositol 4, 5-bisphosphate]
Anemia
Characterization of phosphoinositide kinases in normal and sickle anaemia red cells.
Anemia, Sickle Cell
Characterization of phosphoinositide kinases in normal and sickle anaemia red cells.
Arthritis
Neglected Two-Week-Old Unstable Fracture-Dislocation of the Hip in a 60 Years Old, Managed with Hip Preservation Surgery.
Arthritis
Pipkin type IV femoral head fractures: a case series and review of literature.
Arthritis
[Early primary total hip arthroplasty for acetabular fractures in elderly patients]
Breast Neoplasms
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer.
Breast Neoplasms
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Breast Neoplasms
Increased signal transduction activity and down-regulation in human cancer cells.
Breast Neoplasms
NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase ? and its implication in breast cancer cell proliferation.
Breast Neoplasms
Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells.
Breast Neoplasms
Quercetin down-regulates signal transduction in human breast carcinoma cells.
Breast Neoplasms
Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer.
Carcinoma
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Carcinoma
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
Carcinoma
Increased signal transduction activity and down-regulation in human cancer cells.
Carcinoma
Intracellular signalling: phosphatidylinositol lipid metabolism in cancer cells.
Carcinoma
Regulation of signal transduction.
Carcinoma
Regulation of the signal transduction program by drugs.
Carcinoma
Signal transduction and biochemical targeting of ovarian carcinoma.
Carcinoma
Synergistic action of tiazofurin and genistein in human ovarian carcinoma cells.
Carcinoma
Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells.
Carcinoma, Hepatocellular
1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): a proliferation- and malignancy-linked signal transduction enzyme.
Carcinoma, Hepatocellular
Current issues in the regulation of signal transduction.
Carcinoma, Hepatocellular
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
Carcinoma, Hepatocellular
Increased signal transduction activity and down-regulation in human cancer cells.
Carcinoma, Hepatocellular
Intracellular signalling: phosphatidylinositol lipid metabolism in cancer cells.
Carcinoma, Hepatocellular
Regulation of the signal transduction program by drugs.
Carcinoma, Non-Small-Cell Lung
Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis.
Carcinoma, Ovarian Epithelial
Increased signal transduction activity and down-regulation in human cancer cells.
Colonic Neoplasms
Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a.
Coxa Valga
Femoral Varus Osteotomy for Hip Instability after Traumatic Fracture Dislocations of the Hip Associated with Femoral Head Fractures: A Report of Two Cases.
Dehydration
A gene encoding phosphatidylinositol-4-phosphate 5-kinase is induced by water stress and abscisic acid in Arabidopsis thaliana.
Endometriosis
Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway.
Fracture Dislocation
Femoral Varus Osteotomy for Hip Instability after Traumatic Fracture Dislocations of the Hip Associated with Femoral Head Fractures: A Report of Two Cases.
Fracture Dislocation
Ganz Surgical Dislocation of the Hip Is a Safe Technique for Operative Treatment of Pipkin Fractures. Results of a Prospective Trial.
Fracture Dislocation
Posterior wall acetabulum fracture-dislocation with subsequent ipsilateral pipkin IV fracture-dislocation: How many hits can a hip take?
Fracture Dislocation
Surgical dislocation or the modified Heuter anterior approach for Pipkin I and II femoral head fracture dislocations.
Genetic Diseases, Inborn
Structural insights into lethal contractural syndrome type 3 (LCCS3) caused by a missense mutation of PIP5K?.
Glioma
CircRNA PIP5K1A promotes the progression of glioma through upregulation of the TCF12/PI3K/AKT pathway by sponging miR-515-5p.
Glioma
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
Guillain-Barre Syndrome
Correlation Between Daam2 Expression Changes and Demyelination in Guillain-Barre Syndrome.
Hip Dislocation
A case of pathological fracture caused by vitamin D insufficiency in a young athlete and a review of the literature.
Hip Dislocation
A treatment strategy to avoid iatrogenic Pipkin type III femoral head fracture-dislocations.
Hip Dislocation
Bilateral irreducible asymmetrical fracture-dislocation of the hip: A case report and literature review.
Hip Dislocation
Bilateral posterior hip dislocation associated with right Pipkin II fracture: A case report.
Hip Dislocation
Failed reduction of posterior hip dislocation accompanied by femoral head fracture: causes and resolving strategy.
Hip Dislocation
Management of Pipkin Fractures Using a Safe Surgical Hip Dislocation.
Hip Dislocation
Operative versus nonoperative management of Pipkin type-II fractures associated with posterior hip dislocation.
Hip Dislocation
Rotational osteoplasty and bioabsorbable polylactate pin fixation in Pipkin type 2 fracture with acute osteochondral defect: a case report.
Hip Dislocation
Surgical hip dislocation vs arthroscopy for fixation of subfoveal femoral head fractures: A new technique for Pipkin type 1 fractures.
Hip Dislocation
Transfer of osteochondral shell autografts to salvage femoral head impaction injuries in hip trauma patients.
Hip Dislocation
Treatment of Pipkin type I fracture using safe surgical hip dislocation: A case report.
Hip Dislocation
Trochanteric Flip (Ganz) Anterior Hip Dislocation for Fixation of Pipkin Fracture-Dislocations.
Hip Dislocation
Usefulness of arthroscopic surgery in hip trauma cases.
Infertility
Role of phosphatidylinositol-4-phosphate 5' kinase (ppk-1) in ovulation of Caenorhabditis elegans.
Influenza, Human
A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection.
Intestinal Diseases
Eimeria maxima phosphatidylinositol 4-phosphate 5-kinase: locus sequencing, characterization, and cross-phylum comparison.
Lung Neoplasms
Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis.
Malaria
A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum.
Muscle Weakness
Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.
Neoplasm Metastasis
Cdk5-mediated phosphorylation regulates phosphatidylinositol 4-phosphate 5-kinase type I ? 90 activity and cell invasion.
Neoplasm Metastasis
Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer.
Neoplasms
1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): a proliferation- and malignancy-linked signal transduction enzyme.
Neoplasms
A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase.
Neoplasms
Amplification of signal transduction capacity and down-regulation by drugs.
Neoplasms
Amplified increase in signal transduction activity in cancer cells.
Neoplasms
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Neoplasms
Current issues in the regulation of signal transduction.
Neoplasms
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
Neoplasms
Down-regulation of increased signal transduction capacity in human cancer cells.
Neoplasms
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
Neoplasms
Intracellular signalling: phosphatidylinositol lipid metabolism in cancer cells.
Neoplasms
Oncogenic pathways implicated in ovarian epithelial cancer.
Neoplasms
Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage.
Neoplasms
Phosphatidylinositol phosphate 5-kinase I?i2 in association with Src controls anchorage-independent growth of tumor cells.
Neoplasms
PIP5K1A: a potential target for cancers with KRAS or TP53 mutations.
Neoplasms
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
Neoplasms
Type I Gamma Phosphatidylinositol Phosphate 5-kinase i5 Controls the Ubiquitination and Degradation of a Tumor Suppressor Mitogen-Inducible Gene 6.
Neoplasms
Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer.
Neuroblastoma
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
Neuroblastoma
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling.
Oculocerebrorenal Syndrome
The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule.
Osteoarthritis
Dislocated intra-articular femoral head fracture associated with fracture-dislocation of the hip and acetabulum: report of 12 cases and technical notes on surgical intervention.
Osteoarthritis
STUDY OF THE TREATMENT OF FEMORAL HEAD FRACTURES.
Osteoarthritis
Usefulness of arthroscopic surgery in hip trauma cases.
Osteoarthritis, Hip
Treatment of Pipkin fractures.
Osteoarthritis, Hip
[Treatment of Pipkin fractures]
Osteonecrosis
Ganz Surgical Dislocation of the Hip Is a Safe Technique for Operative Treatment of Pipkin Fractures. Results of a Prospective Trial.
Osteonecrosis
Pipkin type IV femoral head fractures: a case series and review of literature.
Osteonecrosis
Usefulness of arthroscopic surgery in hip trauma cases.
Pancreatic Neoplasms
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
Polycystic Kidney Diseases
Apical PtdIns(4,5)P2 is required for ciliogenesis and suppression of polycystic kidney disease.
Prostatic Neoplasms
Profiling and relative quantitation of phosphoinositides by multiple precursor ion scanning based on phosphate methylation and isotopic labeling.
Sarcoma, Avian
Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cells.
Starvation
Regulation of the signal transduction program by drugs.
Stomach Neoplasms
Type Igamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin.
Tuberculosis
Polyphosphate deficiency in Mycobacterium tuberculosis is associated with enhanced drug susceptibility and impaired growth in guinea pigs.
Whooping Cough
Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells.
Wiskott-Aldrich Syndrome
Effect of ovarian hormones on genes promoting dendritic spines in laser-captured serotonin neurons from macaques.
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additional information
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upon activation by semaphorin 3E, plexin-D1 recruits phosphatidylinositol-4-phosphate 5-kinase, and its enzymatic lipid product, phosphatidylinositol 4,5-bisphosphate, binds to the pleckstrin homology domain of guanine nucleotide exchange protein 100, GEP100. Phosphatidylinositol 4,5-bisphosphate binding to GEP100 enhances its guanine nucleotide exchange factor activity toward Arf6, thus resulting in the disassembly of integrin-mediated focal adhesions and endothelial cell collapse
malfunction
-
isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide
malfunction
-
enzyme knockdown impairs Akt activation in response to both FBS and ECM protein stimulation
malfunction
-
enzyme silencing impairs CD28-mediated IL-8 and IL-2 transcriptional activation
malfunction
downregulation of isoforms PIP5K1alpha and PIP5K1gamma strongly impairs the targeting of HIV-1 Gag polyprotein precursor Pr55Gag to the plasma membrane with a rerouting of the polyprotein within intracellular compartments
malfunction
-
knockdown of isoform PIPKIgammai5 leads to the loss of mitogen-inducible gene 6 expression, which dramatically enhances and prolongs epidermal growth factor receptor-mediated cell signaling
metabolism
-
phosphorylation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the type I PI 4-phosphate 5-kinase (PIP5K) family members including PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma isoforms is the major pathway of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis in mammalian cells
metabolism
enzyme isoform PIP5KIgamma regulates KCNQ2/3 currents and store-operated calcium entry in distinct ways in tsA201 cells
metabolism
enzyme isoforms PIP5KIbeta regulates KCNQ2/3 currents and store-operated calcium entry in distinct ways in tsA201 cells
physiological function
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate regulates many critical cellular events and mediates plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-dependent Toll-like receptor 4 signaling pathway. Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein location
physiological function
-
phosphatidylinositol 4,5 bisphosphate is a major membrane phospholipid that affects cellular processes such as actin cytoskeleton modulation, membrane trafficking and ion channel activity. Isozyme PIP5Kgamma is essential for advanced glycation end products induced inhibition of renal Na+/K+ ATPase activity
physiological function
-
CD28 induces the recruitment of the enzyme to the immunological synapse, where it regulates filamin A and lipid raft accumulation, as well as T cell activation, in a nonredundant manner
physiological function
-
enzyme overexpression promotes class I PI3K and the serine/threoninespecific protein kinase Akt signaling and oncogenic growth
physiological function
-
T lymphocyte triggering is finely tuned by phosphatidylinositol 4,5-biphosphate kinases activity
physiological function
-
the enzyme and sorting nexin 5 protein form a signaling nexus that controls epidermal growth factor receptor endosomal sorting, degradation, and signaling
physiological function
the enzyme functions as a member of the rDNA silencing complex
physiological function
the enzyme interacts with the cytoskeleton regulator IQGAP1 and modulates IQ motif containing GTPase activating protein 1 (IQGAP1) function in migration. The enzyme is required for IQGAP1 recruitment to the leading edge membrane in response to integrin or growth factor receptor activation
physiological function
-
the enzyme is a key modulator of CD28 costimulatory signals and required for CD28-mediated transcription of both interleukin-8 and interleukin-2 genes
physiological function
-
the enzyme is a key modulator of CD28 costimulatory signals leading to the efficient T cell activation. Enzyme recruitment and activation is essential for CD28-mediated cytoskeleton rearrangement necessary for organizing a complete signaling compartment leading to downstream signaling functions
physiological function
-
the enzyme prevents the decrease in the HRG (human ether-a-go-go-related gene) potassium current induced by Gq protein-coupled receptor stimulation
physiological function
-
the enzyme regulates Src activation downstream of growth factor receptors and integrins. The enzyme and Src synergistically control anchorage-independent tumor cell growth
physiological function
-
isoform PIPKIgammai5 controls Mig6 ubiquitination and degradation. Isoform PIPKIgammai5, the E3 ubiquitin ligase neuronal precursor cell-expressed developmentally down-regulated 4-1, and mitogen-inducible gene 6 form a molecular nexus that controls epidermal growth factor receptor activation and downstream signalling
physiological function
-
overexpression of isoform PIP5K1A results in significant enhancement of non-amyloidogenic amyloid precursor protein processing and a concomitant suppression of the amyloidogenic pathway, leading to a marked decrease in secreted amyloid-beta peptide
physiological function
the 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate pools produced by isoforms PIP5K1alpha and gamma are involved in HIV-1 Gag polyprotein precursor Pr55Gag plasma membrane targeting process
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Smith, P.M.; Wreggett, K.A.; Irvine, R.F.
The phosphatidylinositol 4-phosphate kinase of rat brain and human platelets
Biochem. Soc. Trans.
14
1145-1146
1986
Homo sapiens, Rattus norvegicus
-
brenda
Bazenet, C.E.; Anderson, R.A.
Phosphatidylinositol-4-phosphate 5-kinases from human erythrocytes
Methods Enzymol.
209
189-202
1992
Homo sapiens
brenda
Ling, L.E.; Schulz, J.T.; Cantley, L.C.
Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells
J. Biol. Chem.
264
5080-5088
1989
Homo sapiens
brenda
Zhang, X.; Loijens, J.C.; Boronenkov, I.V.; Parker, G.J.; Norris, F.A.; Chen, J.; Thum, O.; Prestwich, G.D.; Majerus, P.W.; Anderson, R.A.
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules
J. Biol. Chem.
272
17756-17761
1997
Homo sapiens
brenda
Oude Weernink, P.A.; Schulte, P.; Guo, Y.; Wetzel, J.; Amano, M.; Kaibuchi, K.; Haverland, S.; Voss, M.; Schmidt, M.; Mayr, G.W.; Jakobs, K.H.
Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase
J. Biol. Chem.
275
10168-10174
2000
Homo sapiens
brenda
Kanaho, Y.; Miyazaki, H.; Yamazaki, M.
Activation of PI(4)P 5-kinase by small G proteins
Adv. Enzyme Regul.
43
107-119
2003
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Oude Weernink, P.A.; Schmidt, M.; Jakobs, K.H.
Regulation and cellular roles of phosphoinositide 5-kinases
Eur. J. Pharmacol.
500
87-99
2004
Saccharomyces cerevisiae, Candida albicans, Homo sapiens, Mus musculus, Schizosaccharomyces pombe
brenda
Perera, I.Y.; Davis, A.J.; Galanopoulou, D.; Im, Y.J.; Boss, W.F.
Characterization and comparative analysis of Arabidopsis phosphatidylinositol phosphate 5-kinase 10 reveals differences in Arabidopsis and human phosphatidylinositol phosphate kinases
FEBS Lett.
579
3427-3432
2005
Arabidopsis thaliana (Q56YP2), Arabidopsis thaliana (Q9LMN1), Homo sapiens (Q99755), Homo sapiens
brenda
Akiyama, C.; Shinozaki-Narikawa, N.; Kitazawa, T.; Hamakubo, T.; Kodama, T.; Shibasaki, Y.
Phosphatidylinositol-4-phosphate 5-kinase gamma is associated with cell-cell junction in A431 epithelial cells
Cell Biol. Int.
29
514-520
2005
Homo sapiens
brenda
Halstead, J.R.; van Rheenen, J.; Snel, M.H.; Meeuws, S.; Mohammed, S.; DSantos, C.S.; Heck, A.J.; Jalink, K.; Divecha, N.
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis
Curr. Biol.
16
1850-1856
2006
Homo sapiens, Mus musculus
brenda
Cabezas, A.; Pattni, K.; Stenmark, H.
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
Gene
371
34-41
2006
Homo sapiens (Q9Y2I7)
brenda
Kisseleva, M.; Feng, Y.; Ward, M.; Song, C.; Anderson, R.A.; Longmore, G.D.
The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha
Mol. Cell. Biol.
25
3956-3966
2005
Homo sapiens
brenda
Nelson, C.D.; Kovacs, J.J.; Nobles, K.N.; Whalen, E.J.; Lefkowitz, R.J.
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor
J. Biol. Chem.
283
21093-21101
2008
Homo sapiens
brenda
Lacalle, R.A.; Peregil, R.M.; Albar, J.P.; Merino, E.; Martinez-A, C.; Merida, I.; Manes, S.
Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement
J. Cell Biol.
179
1539-1553
2007
Homo sapiens
brenda
Lokuta, M.A.; Senetar, M.A.; Bennin, D.A.; Nuzzi, P.A.; Chan, K.T.; Ott, V.L.; Huttenlocher, A.
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis
Mol. Biol. Cell
18
5069-5080
2007
Homo sapiens, Mus musculus
brenda
Xia, Y.; Irvine, R.F.; Giudici, M.L.
Phosphatidylinositol 4-phosphate 5-kinase Igamma_v6, a new splice variant found in rodents and humans
Biochem. Biophys. Res. Commun.
411
416-420
2011
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Gallicchio, M.A.; Bach, L.A.
Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: role of cytosolic phospholipase A2alpha and phosphatidylinositol 4-phosphate 5-kinase gamma
Biochim. Biophys. Acta
1803
919-930
2010
Homo sapiens, Sus scrofa
brenda
Sakurai, A.; Jian, X.; Lee, C.J.; Manavski, Y.; Chavakis, E.; Donaldson, J.; Randazzo, P.A.; Gutkind, J.S.
Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein
J. Biol. Chem.
286
34335-34345
2011
Homo sapiens
brenda
Nguyen, T.T.; Kim, Y.M.; Kim, T.D.; Le, O.T.; Kim, J.J.; Kang, H.C.; Hasegawa, H.; Kanaho, Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location
J. Biol. Chem.
288
5645-5659
2013
Homo sapiens, Mus musculus (P70182)
brenda
Sun, Y.; Hedman, A.C.; Tan, X.; Schill, N.J.; Anderson, R.A.
Endosomal type Igamma PIP 5-kinase controls EGF receptor lysosomal sorting
Dev. Cell
25
144-155
2013
Homo sapiens
brenda
Choi, S.; Thapa, N.; Hedman, A.C.; Li, Z.; Sacks, D.B.; Anderson, R.A.
IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration
EMBO J.
32
2617-2630
2013
Homo sapiens (O60331)
brenda
Lacalle, R.A.; de Karam, J.C.; Martinez-Munoz, L.; Artetxe, I.; Peregil, R.M.; Sot, J.; Rojas, A.M.; Goni, F.M.; Mellado, M.; Manes, S.
Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity
FASEB J.
29
2371-2385
2015
Homo sapiens
brenda
Porciello, N.; Kunkl, M.; Viola, A.; Tuosto, L.
Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation
Front. Immunol.
7
186
2016
Homo sapiens
brenda
Thapa, N.; Choi, S.; Hedman, A.; Tan, X.; Anderson, R.A.
Phosphatidylinositol phosphate 5-kinase Igammai2 in association with Src controls anchorage-independent growth of tumor cells
J. Biol. Chem.
288
34707-34718
2013
Homo sapiens
brenda
Thapa, N.; Choi, S.; Tan, X.; Wise, T.; Anderson, R.A.
Phosphatidylinositol phosphate 5-kinase Igamma and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth
J. Biol. Chem.
290
18843-18854
2015
Homo sapiens
brenda
Chakrabarti, R.; Sanyal, S.; Ghosh, A.; Bhar, K.; Das, C.; Siddhanta, A.
Phosphatidylinositol-4-phosphate 5-kinase 1alpha modulates ribosomal RNA gene silencing through its interaction with histone H3 lysine 9 trimethylation and heterochromatin protein HP1-alpha
J. Biol. Chem.
290
20893-20903
2015
Homo sapiens (Q99755)
brenda
Muscolini, M.; Camperio, C.; Capuano, C.; Caristi, S.; Piccolella, E.; Galandrini, R.; Tuosto, L.
Phosphatidylinositol 4-phosphate 5-kinase alpha activation critically contributes to CD28-dependent signaling responses
J. Immunol.
190
5279-5286
2013
Homo sapiens
brenda
Muscolini, M.; Camperio, C.; Porciello, N.; Caristi, S.; Capuano, C.; Viola, A.; Galandrini, R.; Tuosto, L.
Phosphatidylinositol 4-phosphate 5-kinase alpha and Vav1 mutual cooperation in CD28-mediated actin remodeling and signaling functions
J. Immunol.
194
1323-1333
2015
Homo sapiens
brenda
Kallikourdis, M.; Trovato, A.E.; Roselli, G.; Muscolini, M.; Porciello, N.; Tuosto, L.; Viola, A.
Phosphatidylinositol 4-phosphate 5-kinase beta controls recruitment of lipid rafts into the immunological synapse
J. Immunol.
196
1955-1963
2016
Homo sapiens
brenda
Kubo, T.; Ding, W.G.; Toyoda, F.; Fujii, Y.; Omatsu-Kanbe, M.; Matsuura, H.
Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation
J. Pharmacol. Sci.
127
127-134
2015
Homo sapiens
brenda
Wu, P.F.; Bhore, N.; Lee, Y.L.; Chou, J.Y.; Chen, Y.W.; Wu, P.Y.; Hsu, W.M.; Lee, H.; Huang, Y.S.; Lu, P.J.; Liao, Y.F.
Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein
FASEB J.
34
12127-12146
2020
Homo sapiens
brenda
Sun, M.; Cai, J.; Anderson, R.A.; Sun, Y.
Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls the ubiquitination and degradation of the tumor suppressor mitogen-inducible gene 6
J. Biol. Chem.
291
21461-21473
2016
Homo sapiens
brenda
De La Cruz, L.; Traynor-Kaplan, A.; Vivas, O.; Hille, B.; Jensen, J.
Plasma membrane processes are differentially regulated by type I phosphatidylinositol phosphate 5-kinases and RASSF4
J. Cell Sci.
133
jcs233254
2020
Homo sapiens (O14986), Homo sapiens (O60331)
brenda
Gonzales, B.; de Rocquigny, H.; Beziau, A.; Durand, S.; Burlaud-Gaillard, J.; Lefebvre, A.; Krull, S.; Emond, P.; Brand, D.; Piver, E.
Type I phosphatidylinositol-4-phosphate 5-kinases alpha and gamma play a key role in targeting HIV-1 Pr55Gag to the plasma membrane
J. Virol.
94
e00189-20
2020
Homo sapiens (O60331), Homo sapiens (Q99755)
brenda
Yang, Y.; Park, M.; Maekawa, M.; Fairn, G.D.
Enforced expression of phosphatidylinositol 4-phosphate 5-kinase homolog alters PtdIns(4,5)P2 distribution and the localization of small G-proteins
Sci. Rep.
9
14789
2019
Homo sapiens
brenda