Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1,2-dipalmitoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1,2-dipalmitoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ATP + 1-stearoyl-2-arachidonoyl phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-stearoyl-2-arachidonoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-stearoyl-2-oleoyl phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-stearoyl-2-oleoyl phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + dipalmitoyl phosphatidylinositol 4-phosphate
ADP + dipalmitoylphosphatidylinositol 4,5-bisphosphate
-
-
-
-
?
additional information
?
-
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
641839, 641846, 641847, 641848, 641853, 660641, 660875, 661660, 662494, 662546, 672374, 673185, 673332, 673679, 675019, 676789, 722784, 723653, 737960, 738165, 739178, 759034 -
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the activity of the enzyme is regulated by the reversible balance between cAMP-dependent protein kinase-dependent phosphorylation and protein phosphatase 1-dependent dephosphorylation
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
enzyme type 1beta is essential for epidermal growth factor receptor-mediated endocytosis
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
in addition to regulating early steps in endocytosis, the enzyme acts through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to regulate endosomal trafficking and/or fusion
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIP-5kina-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis. PIPKIalpha appears to contribute to the transient changes in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels that are associated with, and likely required for, the recruitment and regulation of actin-modulating proteins
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIP 5-kinase alpha is a critical mediator of thrombin- and Rac-dependent actin assembly
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme plays an essential role during neurite retraction in response to a number of diverse stimuli
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, especially produced by isozyme beta, is required for constitutive endocytosis of transferrin receptors via clathrin-coated pits, and probably also for the regulation thereof
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme activity is regulated by Arf6 activation
-
-
?
additional information
?
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production by the enzyme, presence of Arf6, and binding of the bacterial invasin protein to beta1 integrin receptors are required for the small GTPase Rac1-dependent pathway, which is activated for efficient entry of the bacterium Yersinia pseudotuberculosis, into mammalian cells, overview
-
-
?
additional information
?
-
-
enzyme is important in cell signaling and cell shaping, overview, the enzyme is essential for regulation of neurite modeling, ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
additional information
?
-
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the activity of the enzyme is regulated by the reversible balance between cAMP-dependent protein kinase-dependent phosphorylation and protein phosphatase 1-dependent dephosphorylation
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
enzyme type 1beta is essential for epidermal growth factor receptor-mediated endocytosis
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
in addition to regulating early steps in endocytosis, the enzyme acts through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to regulate endosomal trafficking and/or fusion
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIP-5kina-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis. PIPKIalpha appears to contribute to the transient changes in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels that are associated with, and likely required for, the recruitment and regulation of actin-modulating proteins
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
PIP 5-kinase alpha is a critical mediator of thrombin- and Rac-dependent actin assembly
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme plays an essential role during neurite retraction in response to a number of diverse stimuli
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, especially produced by isozyme beta, is required for constitutive endocytosis of transferrin receptors via clathrin-coated pits, and probably also for the regulation thereof
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
the enzyme activity is regulated by Arf6 activation
-
-
?
additional information
?
-
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production by the enzyme, presence of Arf6, and binding of the bacterial invasin protein to beta1 integrin receptors are required for the small GTPase Rac1-dependent pathway, which is activated for efficient entry of the bacterium Yersinia pseudotuberculosis, into mammalian cells, overview
-
-
?
additional information
?
-
-
enzyme is important in cell signaling and cell shaping, overview, the enzyme is essential for regulation of neurite modeling, ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
?
additional information
?
-
-
subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide. Isozyme PIP5Kalpha shRNA-15 knockdown cells are less effective inducing iNOS protein expression and nitric oxide production after lipopolysaccharide stimulation overnight and for 24 h, respectively, compared with control cells
metabolism
phosphorylation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the type I PI 4-phosphate 5-kinase (PIP5K) family members including PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma isoforms is the major pathway of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis in mammalian cells
physiological function
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate regulates many critical cellular events and mediates plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-dependent Toll-like receptor 4 signaling pathway. Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein location
additional information
-
identification of the binding domain for His6-tagged KIF2A and GST-tagged PIPKalpha interaction, overview
malfunction
-
enzyme knockoout mutants are infertile, phenotypes, overview. Flagella of sperm from isozyme Pip5k1a knockout mutant and even more of Pip5k1a/Pip5k1b double-knockout mutant mice remarkably undergo morphological changes and impairment, whereas Pip5k1b-knockout mutant sperm is morphologically normal. F-actin organization in the seminiferous epithelium is disrupted by the loss of PIP5K1A and PIP5K1B
malfunction
-
overexpression of PIPKalpha inhibits axon elongation via KIF2A in N1E-115 neuroblastoma cells
malfunction
-
enzyme knockdown affects the recruitment of talin and focal adhesion kinase to the plasma membrane
malfunction
-
isoform PIP5Kalpha knockdown of BV-2 cells significantly suppresses lipoteichoic acid-induced activation of toll-like receptor 2 downstream signaling, including the production of proinflammatory cytokines and phosphorylation of nuclear factor-kappaB, JNK, and p38 MAP kinase. Besides, isoform PIP5Kalpha knockdown inhibits phagocytic uptake of Escherichia coli particles and autophagy-related vesicle formation triggered by lipoteichoic acid
physiological function
-
isozyme phosphatidylinositol 4-phosphate 5-kinase alpha, PIPKalpha, regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches, unique PIPK-mediated KIF2A-dependent mechanism controlling microtubule dynamics in neuronal development, overview. Murine PIPKalpha as a negative regulator of neurite formation in N1E-115 neuroblastoma cells and early-stage hippocampal neurons
physiological function
-
the lipid kinase phosphatidylinositol 4-phosphate 5-kinase produces a versatile signaling phospholipid, phosphatidylinositol 4,5-bisphosphate, isozymes PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis
physiological function
-
the enzyme negatively regulates axon elongation and growth cone size and is involved in the cellular signaling pathway for Sema3A-triggered repulsion in dorsal root ganglion neurons
physiological function
-
the enzyme plays an essential role in neuronal migration, possibly through recruitment of adhesion components to the plasma membrane
physiological function
-
phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Galiano, F.J.; Ulug, E.T.; Davis, J.N.
Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Ibeta disrupts a phosphatidylinositol 4,5 bisphosphate regulated endosomal pathway
J. Cell. Biochem.
85
131-145
2002
Mus musculus
brenda
Barbieri, M.A.; Heath, C.M.; Peters, E.M.; Wells, A.; Davis, J.N.; Stahl, P.D.
Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis
J. Biol. Chem.
276
47212-47216
2001
Mus musculus
brenda
Coppolino, M.G.; Dierckman, R.; Loijens, J.; Collins, R.F.; Pouladi, M.; Jongstra-Bilen, J.; Schreiber, A.D.; Trimble, W.S.; Anderson, R.; Grinstein, S.
Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis
J. Biol. Chem.
277
43849-43857
2002
Mus musculus
brenda
Yamazaki, M.; Miyazaki, H.; Watanabe, H.; Sasaki, T.; Maehama, T.; Frohman, M.A.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling
J. Biol. Chem.
277
17226-17230
2002
Mus musculus
brenda
Tolias, K.F.; Hartwig, J.H.; Ishihara, H.; Shibasaki, Y.; Cantley, L.C.; Carpenter, C.L.
Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
Curr. Biol.
10
153-156
2000
Mus musculus
brenda
Park, S.J.; Itoh, T.; Takenawa, T.
Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli
J. Biol. Chem.
276
4781-4787
2001
Mus musculus
brenda
van Horck, F.P.; Lavazais, E.; Eickholt, B.J.; Moolenaar, W.H.; Divecha, N.
Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling
Curr. Biol.
12
241-245
2002
Mus musculus
brenda
Kanaho, Y.; Miyazaki, H.; Yamazaki, M.
Activation of PI(4)P 5-kinase by small G proteins
Adv. Enzyme Regul.
43
107-119
2003
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Arioka, M.; Nakashima, S.; Shibasaki, Y.; Kitamoto, K.
Dibasic amino acid residues at the carboxy-terminal end of kinase homology domain participate in the plasma membrane localization and function of phosphatidylinositol 5-kinase gamma
Biochem. Biophys. Res. Commun.
319
456-463
2004
Mus musculus
brenda
Oude Weernink, P.A.; Schmidt, M.; Jakobs, K.H.
Regulation and cellular roles of phosphoinositide 5-kinases
Eur. J. Pharmacol.
500
87-99
2004
Saccharomyces cerevisiae, Candida albicans, Homo sapiens, Mus musculus, Schizosaccharomyces pombe
brenda
Padron, D.; Wang, Y.J.; Yamamoto, M.; Yin, H.; Roth, M.G.
Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis
J. Cell Biol.
162
693-701
2003
Mus musculus
brenda
Wong, K.W.; Isberg, R.R.
Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake
J. Exp. Med.
198
603-614
2003
Mus musculus
brenda
Perez-Mansilla, B.; Ha, V.L.; Justin, N.; Wilkins, A.J.; Carpenter, C.L.; Thomas, G.M.
The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6
Biochim. Biophys. Acta
1761
1429-1442
2006
Mus musculus
brenda
Halstead, J.R.; van Rheenen, J.; Snel, M.H.; Meeuws, S.; Mohammed, S.; DSantos, C.S.; Heck, A.J.; Jalink, K.; Divecha, N.
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis
Curr. Biol.
16
1850-1856
2006
Homo sapiens, Mus musculus
brenda
Nakano-Kobayashi, A.; Yamazaki, M.; Unoki, T.; Hongu, T.; Murata, C.; Taguchi, R.; Katada, T.; Frohman, M.A.; Yokozeki, T.; Kanaho, Y.
Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis
EMBO J.
26
1105-1116
2007
Mus musculus
brenda
Giudici, M.L.; Lee, K.; Lim, R.; Irvine, R.F.
The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants
FEBS Lett.
580
6933-6937
2006
Mus musculus
brenda
Jarquin-Pardo, M.; Fitzpatrick, A.; Galiano, F.J.; First, E.A.; Davis, J.N.
Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate
J. Cell. Biochem.
100
112-128
2007
Mus musculus
brenda
Gong, L.W.; Di Paolo, G.; Diaz, E.; Cestra, G.; Diaz, M.E.; Lindau, M.; De Camilli, P.; Toomre, D.
Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion
Proc. Natl. Acad. Sci. USA
102
5204-5209
2005
Mus musculus
brenda
Weixel, K.M.; Edinger, R.S.; Kester, L.; Guerriero, C.J.; Wang, H.; Fang, L.; Kleyman, T.R.; Welling, P.A.; Weisz, O.A.; Johnson, J.P.
Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells
J. Biol. Chem.
282
36534-36542
2007
Mus musculus
brenda
Lokuta, M.A.; Senetar, M.A.; Bennin, D.A.; Nuzzi, P.A.; Chan, K.T.; Ott, V.L.; Huttenlocher, A.
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis
Mol. Biol. Cell
18
5069-5080
2007
Homo sapiens, Mus musculus
brenda
Xia, Y.; Irvine, R.F.; Giudici, M.L.
Phosphatidylinositol 4-phosphate 5-kinase Igamma_v6, a new splice variant found in rodents and humans
Biochem. Biophys. Res. Commun.
411
416-420
2011
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Hasegawa, H.; Noguchi, J.; Yamashita, M.; Okada, R.; Sugimoto, R.; Furuya, M.; Unoki, T.; Funakoshi, Y.; Baba, T.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis
Biol. Reprod.
86:136
1-12
2012
Mus musculus
brenda
Shulga, Y.V.; Anderson, R.A.; Topham, M.K.; Epand, R.M.
Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator
J. Biol. Chem.
287
35953-35963
2012
Mus musculus
brenda
Nguyen, T.T.; Kim, Y.M.; Kim, T.D.; Le, O.T.; Kim, J.J.; Kang, H.C.; Hasegawa, H.; Kanaho, Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location
J. Biol. Chem.
288
5645-5659
2013
Homo sapiens, Mus musculus (P70182)
brenda
Noda, Y.; Niwa, S.; Homma, N.; Fukuda, H.; Imajo-Ohmi, S.; Hirokawa, N.
Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKalpha) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches
Proc. Natl. Acad. Sci. USA
109
1725-1730
2012
Mus musculus
brenda
Sakagami, H.; Katsumata, O.; Hara, Y.; Tamaki, H.; Fukaya, M.
Preferential localization of type I phosphatidylinositol 4-phosphate 5-kinase gamma at the periactive zone of mouse photoreceptor ribbon synapses
Brain Res.
1586
23-33
2014
Mus musculus
brenda
Hara, Y.; Fukaya, M.; Tamaki, H.; Sakagami, H.
Type I phosphatidylinositol 4-phosphate 5-kinase gamma is required for neuronal migration in the mouse developing cerebral cortex
Eur. J. Neurosci.
38
2659-2671
2013
Mus musculus
brenda
Yamazaki, M.; Yamauchi, Y.; Goshima, Y.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase beta regulates growth cone morphology and semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons
Neurosci. Lett.
547
59-64
2013
Mus musculus
brenda
Nguyen, T.T.N.; Seo, E.; Choi, J.; Le, O.T.T.; Kim, J.Y.; Jou, I.; Lee, S.Y.
Phosphatidylinositol 4-phosphate 5-kinase alpha contributes to toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid
Cell. Signal.
38
159-170
2017
Mus musculus
brenda
Khrongyut, S.; Rawangwong, A.; Pidsaya, A.; Sakagami, H.; Kondo, H.; Hipkaeo, W.
Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) alpha, beta, gamma in the three major salivary glands in situ of mice and their response to beta-adrenoceptor stimulation
J. Anat.
234
502-514
2019
Mus musculus (O70161), Mus musculus (P70181), Mus musculus (P70182)
brenda