Information on EC 2.7.1.51 - L-fuculokinase

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The expected taxonomic range for this enzyme is: Enterobacteriaceae

EC NUMBER
COMMENTARY
2.7.1.51
-
RECOMMENDED NAME
GeneOntology No.
L-fuculokinase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ATP + L-fuculose = ADP + L-fuculose 1-phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Fructose and mannose metabolism
-
fucose degradation
-
SYSTEMATIC NAME
IUBMB Comments
ATP:L-fuculose 1-phosphotransferase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
kinase, L-fuculo- (phosphorylating)
-
-
-
-
L-fuculose kinase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9026-64-6
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
PRL-R3, strain 176
-
-
Manually annotated by BRENDA team
K-12 mutant strain 1102 derived from parent strain 1000
-
-
Manually annotated by BRENDA team
strain O-111 B4
-
-
Manually annotated by BRENDA team
Escherichia coli O-111 B4
strain O-111 B4
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + D-fructose
ADP + D-fructose 1-phosphate
show the reaction diagram
Escherichia coli, Citrobacter freundii, Escherichia coli O-111 B4
-
phosphorylation at about 45% the rate of L-fuculose
-
-
?
ATP + D-ribulose
ADP + D-ribulose 1-phosphate
show the reaction diagram
Escherichia coli, Citrobacter freundii, Escherichia coli O-111 B4
-
phosphorylation at about 40% the rate of L-fuculose, not L-ribulose
-
-
?
ATP + D-xylulose
ADP + D-xylulose 1-phosphate
show the reaction diagram
Escherichia coli, Citrobacter freundii, Escherichia coli O-111 B4
-
phosphorylation at about 40% the rate of L-fuculose
-
-
?
ATP + L-fuculose
ADP + L-fuculose 1-phosphate
show the reaction diagram
-
-
-
-
-
ATP + L-fuculose
ADP + L-fuculose 1-phosphate
show the reaction diagram
-
specific for ATP, cannot be replaced by GTP, ITP, CTP or UTP, no substrates are L-fucose, D-psicose, D-tagatose, L-sorbose, 6-deoxy-L-sorbose or L-rhamnulose
-
?
ATP + L-fuculose
ADP + L-fuculose 1-phosphate
show the reaction diagram
-
involved in L-fucose metabolism, inducible
-
-
-
ATP + L-fuculose
ADP + L-fuculose 1-phosphate
show the reaction diagram
Escherichia coli O-111 B4
-
specific for ATP, cannot be replaced by GTP, ITP, CTP or UTP, no substrates are L-fucose, D-psicose, D-tagatose, L-sorbose, 6-deoxy-L-sorbose or L-rhamnulose
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + L-fuculose
ADP + L-fuculose 1-phosphate
show the reaction diagram
-
-
-
-
-
ATP + L-fuculose
ADP + L-fuculose 1-phosphate
show the reaction diagram
-
involved in L-fucose metabolism, inducible
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ca2+
-
activation, about 50% as efficient as Mn2+ or Mg2+
Co2+
-
activation, about 50% as efficient as Mn2+ or Mg2+
Mg2+
-
requirement, as efficient as Mn2+
Mn2+
-
requirement, as efficient as Mg2+
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
1.4
-
L-Fuculose
-
-
1.4
-
L-Fuculose
-
pH 7.8, 37°C
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.106
1.24
-
several wild-type and mutant strains
0.966
-
-
pH 7.8, 37°C
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6
8.6
-
about half-maximal activity at pH 6 and 8.6
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
PDB
SCOP
CATH
ORGANISM
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE