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5'-nucleotidase deficiency
A basis of the acanthocytosis in inherited and acquired disorders.
5'-nucleotidase deficiency
[Hemolytic anemias caused by erythrocyte enzyme disorders]
6-phosphofructokinase deficiency
Kinetic properties of mutant enzymes in erythrocyte phosphofructokinase deficiency and erythrocyte pyruvate kinase deficiency.
Acute Kidney Injury
Pyruvate kinase M2 mediates fibroblast proliferation to promote tubular epithelial cell survival in acute kidney injury.
Acute Kidney Injury
Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury.
Adenocarcinoma
Changes in glucose transport activities in mammary adenocarcinoma of dogs.
Adenocarcinoma
Comparison of Plasma Tu-M2-PK and CA19-9 in Pancreatic Cancer.
Adenocarcinoma
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Adenocarcinoma
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Adenocarcinoma
Identification of Differentiation-Related Proteins in Gastric Adenocarcinoma Tissues by Proteomics.
Adenocarcinoma
Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2.
Adenocarcinoma
Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.
Adenocarcinoma
Pyruvate Kinase Muscle Isoenzyme 2 (PKM2) Expression Is Associated with Overall Survival in Pancreatic Ductal Adenocarcinoma.
Adenocarcinoma
Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species.
Adenocarcinoma
The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus.
Adenocarcinoma
[Immunohistologic photometric quantification of pyruvate kinase content of rat tumors]
Adenocarcinoma
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
Adenocarcinoma of Lung
Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma.
Adenoma
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Adenoma
Enzymatic characteristics of tubular adenomas and carcinomas of the large intestine.
Adenoma
Evaluation of the Performance of a Fecal Tumor M2-PK Rapid Kit Using Stool Specimens for Detection of Colorectal Tumors.
Adenoma
Faecal biomarkers do not always identify pre-cancerous lesions in patients who present in primary care with bowel symptoms.
Adenoma
Faecal tumour pyruvate kinase M2: not a good marker for the detection of colorectal adenomas.
Adenoma
Hepatic preneoplasia in hepatitis B virus transgenic mice.
Adenoma
Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.
Adenoma
Pyruvate kinase in normal human thyroid tissue and thyroid neoplasms.
Adenoma
Reply: Faecal tumour pyruvate kinase M2: not a good marker for detection of colorectal adenomas.
Adenoma
Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study.
Adenoma
Tumor pyruvate kinase isoenzyme type M2 and immunochemical fecal occult blood test: performance in screening for colorectal cancer.
Adenoma, Liver Cell
Biochemical microanalysis of pyruvate kinase activity in preneoplastic and neoplastic liver lesions induced in rats by N-nitrosomorpholine.
Adenoma, Liver Cell
Unusual histochemical pattern in preneoplastic hepatic foci characterized by hyperactivity of several enzymes.
Adenoma, Oxyphilic
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
Adenoma, Oxyphilic
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
Adenomatous Polyps
Expression of tumor pyruvate kinase M2 isoform in plasma and stool of patients with colorectal cancer or adenomatous polyps.
adenosine deaminase deficiency
Ultra-performance liquid chromatography-tandem mass spectrometry-based multiplex enzyme assay for six enzymes associated with hereditary hemolytic anemia.
adenylate kinase deficiency
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Adrenoleukodystrophy
Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy.
Alkalosis
[Redox processes in the retina and tunic tissues of the rat eye in experimental alkalosis]
alpha-Thalassemia
Coexistence of alpha-thalassemia and a new pyruvate kinase variant: PK Fukien.
alpha-Thalassemia
Erythrocyte glucose-6-phosphate dehydrogenase and pyruvate kinase activities in hemoglobin H disease.
alpha-Thalassemia
Pyruvate kinase deficiency in an alpha-thalassemia family: first case report in Thailand.
alpha-Thalassemia
Rapid flow cytometric test using eosin-5-maleimide for diagnosis of red blood cell membrane disorders.
Altitude Sickness
Effect of chronic altitude hypoxia on hematologic and glycolytic parameters.
Altitude Sickness
Red cell glycolytic intermediates in normal, anaemic and transfused human fetuses.
Alzheimer Disease
Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease.
Alzheimer Disease
Amyloid-? peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex.
Anaplasmosis
The effect of Anaplasma marginale on the glycolytic pathway in bovine erythrocytes.
Anemia
A deficient pyruvate kinase with an electrophoretically slow-moving component.
Anemia
A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency.
Anemia
A new variant of erythrocyte pyruvate kinase - PK "maebashi".
Anemia
An autopsy case of pyruvate kinase deficiency anemia associated with severe hemochromatosis.
Anemia
Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE).
Anemia
Canine erythrocyte pyruvate kinase. II. Properties of abnormal enzyme associated with hemolytic anemia in the Basenji dog.
Anemia
Coexistence of congenital red cell pyruvate kinase and band 3 deficiency.
Anemia
Coinheritance of hereditary ellyptocytosis, pyruvate kinase, and glucose-6-phosphate dehidrogenase mutations. A rare anemia diagnostic paradigm.
Anemia
Congenital dyserythropoietic anemia associated to a GATA1 mutation aggravated by pyruvate kinase deficiency.
Anemia
Congenital Hemolytic Anemias: Is There a Role for the Immune System?
Anemia
Detection of G6PD and pyruvate kinase deficiencies in reticulocytosis by reference to erythrocyte creatine.
Anemia
Enzymic stability of red cells in iron deficiency anaemia. I. Stability of adenosine triphosphate and activity of pyruvate kinase.
Anemia
Equine infectious anemia. Pyruvate kinase deficiency in the red cells of thoroughbred horses.
Anemia
Erythrocyte PK deficiency: biochemical characterization of a patient with haemolytic anemia.
Anemia
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. I. Cell morphology.
Anemia
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. II. Cell deformability.
Anemia
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
Anemia
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
Anemia
Failure of partial splenectomy to ameliorate the anemia of pyruvate kinase deficiency.
Anemia
Fetal anaemia due to pyruvate kinase deficiency.
Anemia
Fragility of abnormal erythrocytes evaluated by response to shear stress.
Anemia
G6PD/PK ratio: a reliable parameter to identify glucose-6-phosphate dehydrogenase deficiency associated with microcytic anemia in heterozygous subjects.
Anemia
Haemolytic anaemia in Basenji dogs. 2. Partial deficiency of erythrocyte pyruvate kinase (PK; EC 2.7.1.40) in heterozygous carriers.
Anemia
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Anemia
Hepatosplenomegaly as the only prenatal finding in a fetus with pyruvate kinase deficiency anemia.
Anemia
Hepcidin and Anemia: A Tight Relationship.
Anemia
How I do in front of an hemolytic anemia of unknown etiology?
Anemia
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
Anemia
In silico-screening approaches for lead generation: identification of novel allosteric modulators of human-erythrocyte pyruvate kinase.
Anemia
Increased IgG molecules bound to the surface of red blood cells of patients with sickle cell anemia.
Anemia
Ineffective erythropoiesis in mutant mice with deficient pyruvate kinase activity.
Anemia
Inherited erythrocyte pyruvate kinase deficiency: Studies on 15 members of two related families.
Anemia
Inherited pyruvate kinase deficiency and normal haematologic values in Australian Basenji dogs.
Anemia
Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in the PKLR gene (p.Arg518fs), and low hepcidin to ferritin ratios.
Anemia
Laboratory approach to investigation of anemia with a focus on pyruvate kinase deficiency.
Anemia
Mechanical membrane properties of human red blood cells and their change due to metabolic disturbance.
Anemia
Molecular Analyses of Pyruvate Kinase Deficient Turkish Patients from a Single Center.
Anemia
Molecular and clinical heterogeneity in pyruvate kinase deficiency in India.
Anemia
Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in the PKLR gene.
Anemia
Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
Anemia
Pathogenesis, laboratory diagnosis, and clinical implications of erythrocyte enzyme deficiencies in dogs, cats, and horses.
Anemia
PK-LR gene mutations in pyruvate kinase deficient Portuguese patients.
Anemia
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Anemia
Pyruvate kinase activity of erythrocytes in hereditary non-spherocytic hemolytic anemias.
Anemia
Pyruvate kinase deficiency anaemia in a Basenji dog.
Anemia
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
Anemia
Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn.
Anemia
Pyruvate kinase deficiency of mice associated with nonspherocytic hemolytic anemia and cure of the anemia by marrow transplantation without host irradiation.
Anemia
Pyruvate kinase deficient hemolytic anemia in the Northern Irish population.
Anemia
Red cell glycolytic intermediates in normal, anaemic and transfused human fetuses.
Anemia
Red cell pyruvate kinase deficiency in Spain: A study of 15 cases.
Anemia
Relative red blood cell enzyme levels as a clue to the diagnosis of pyruvate kinase deficiency.
Anemia
Reticulocyte-dependent labeling alterations of red cell membrane in pyruvate kinase deficiency anemia.
Anemia
Severe pyruvate kinase deficiency anemia. A case report.
Anemia
Spontaneous splenic rupture in primary cytomegalovirus infection.
Anemia
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.
Anemia
Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusiondependent pyruvate kinase deficiency anemia.
Anemia
Successful Liver Transplants for Liver Failure Associated With Pyruvate Kinase Deficiency.
Anemia
Surface ultrastructure of pyruvate kinase-deficient erythrocytes in the Basenji dog.
Anemia
Tanaka KR, Valentine WN, Miwa S. Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia. Blood. 1962;19(3):267-295.
Anemia
The allosteric regulation of pyruvate kinase.
Anemia
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
Anemia
The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.
Anemia
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ?-thalassemia mouse model.
Anemia
[A family study on pyruvate kinase deficiency anemia]
Anemia
[Apropos of 3 new types of hemolytic anemia in children. Infantile pyknocytosis. Familial hemolytic anemia with erythrocytic inclusions and pigmenturia. Anemia caused by a deficiency of pyruvate kinase.]
Anemia
[Clinical studies on hereditary nonspherocytic anemia with erythrocyte pyruvate kinase deficiency]
Anemia
[Diagnosis of pyruvate kinase deficiency]
Anemia
[Erythrocyte pyruvate kinase in healthy subjects and in nonspherocytic hemolytic pyruvate-kinase deficiency anemia]
Anemia
[Erythrocytic pyruvate kinase. II. Enzymatic heterogeneity of deficiencies. Studies concerning 28 cases with congenital hemolytic anemia]
Anemia
[Glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency]
Anemia
[Hemolytic anemias with pyruvate kinase deficiency]
Anemia
[HEREDITARY HEMOLYTIC ANEMIAS WITH PYRUVATE KINASE DEFICIENCY.]
Anemia
[On indications of spleen extirpation in nonspherocytic hemolytic anemias. Favorable success in pyruvate kinase deficiency]
Anemia
[Prenatal diagnosis of homozygous pyruvate kinase deficiency]
Anemia
[Problems in hemolytic anemias with insufficient pyruvate kinase. II. Identification of mutants of pyruvate kinase]
Anemia
[Problems in hemolytic anemias with pyruvate kinase deficiency. I. Clinical and hematologic picture in 4 patients]
Anemia
[Problems of erythrocyte metabolism in anemias with pyruvate kinase deficiency]
Anemia
[Pyruvate kinase activity of erythrocytes in hereditary non-spherocytic hemolytic anemias]
Anemia
[Pyruvate kinase deficiency in the newborn infant]
Anemia
[Significance of kinetic abnormalities of erythrocyte pyruvate kinase in congenital deficiencies]
Anemia
[Studies on erythrocyte metabolism in various hemolytic anemias: with special reference to pyruvate kinase deficiency]
Anemia, Aplastic
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Anemia, Aplastic
Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia.
Anemia, Aplastic
[Relative deficiency of glutathione reductase and or pyruvate kinase in erythrocytes in aplastic anemia and acute leukemia]
Anemia, Diamond-Blackfan
Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia.
Anemia, Diamond-Blackfan
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Anemia, Diamond-Blackfan
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Anemia, Dyserythropoietic, Congenital
Congenital dyserythropoietic anemia associated to a GATA1 mutation aggravated by pyruvate kinase deficiency.
Anemia, Dyserythropoietic, Congenital
Congenital Hemolytic Anemias: Is There a Role for the Immune System?
Anemia, Dyserythropoietic, Congenital
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
Anemia, Dyserythropoietic, Congenital
Hepcidin and Anemia: A Tight Relationship.
Anemia, Dyserythropoietic, Congenital
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Anemia, Hemolytic
A CASE OF CONGENITAL ATYPICAL HAEMOLYTIC ANAEMIA WITH PYRUVATE KINASE DEFICIENCY.
Anemia, Hemolytic
A case of haemolytic anaemia due to pyruvate kinase deficiency.
Anemia, Hemolytic
A case of hereditary spherocytosis misdiagnosed as pyruvate kinase deficient hemolytic anemia.
Anemia, Hemolytic
A case of severe pyruvate kinase deficiency in a primigravida: successful outcome.
Anemia, Hemolytic
A Family Affected by a Life-Threatening Erythrocyte Defect Caused by Pyruvate Kinase Deficiency With Normal Iron Status: A Case Report.
Anemia, Hemolytic
A kindred with red cell pyruvate kinase deficiency.
Anemia, Hemolytic
A New Variant of PKLR Gene Associated With Mild Hemolysis may be Responsible for the Misdiagnosis in Pyruvate Kinase Deficiency.
Anemia, Hemolytic
A Novel and a Previously Described Compound Heterozygous PKLR Gene Mutations Causing Pyruvate Kinase Deficiency in a Chinese Child.
Anemia, Hemolytic
A pyruvate kinase variant with an increased affinity for phosphoenolpyruvate in an individual with congenital non-spherocytic haemolytic anaemia.
Anemia, Hemolytic
A Sri Lankan girl with a new genetic variant in the PKLR gene causing pyruvate kinase deficiency: a case report.
Anemia, Hemolytic
Acquired hemolytic anemia associated with infectious mononucleosis in a patient with congenital pyruvate kinase deficiency.
Anemia, Hemolytic
Acquired pyruvate kinase deficiency.
Anemia, Hemolytic
Addressing the diagnostic gaps in pyruvate kinase deficiency: Consensus recommendations on the diagnosis of pyruvate kinase deficiency.
Anemia, Hemolytic
Adoptive immunotherapy to increase the level of donor hematopoietic chimerism after nonmyeloablative marrow transplantation for severe canine hereditary hemolytic anemia.
Anemia, Hemolytic
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Anemia, Hemolytic
Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia.
Anemia, Hemolytic
Alu element insertion in PKLR gene as a novel cause of pyruvate kinase deficiency in Middle Eastern patients.
Anemia, Hemolytic
AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency.
Anemia, Hemolytic
An isozyme of erythrocyte pyruvate kinase (PK-Los Angeles) with impaired kinetics corrected by fructose-1, 6-diphosphate.
Anemia, Hemolytic
Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency.
Anemia, Hemolytic
Atypical pyruvate kinase in a family with spherocytic haemolytic anaemia.
Anemia, Hemolytic
Atypical pyruvate kinase in a patient with haemolytic anaemia.
Anemia, Hemolytic
Bilirubin cholelithiasis and haemosiderosis in an anaemic pyruvate kinase-deficient Somali cat.
Anemia, Hemolytic
Biochemical and molecular characterization of variant pyruvate kinase enzymes and genes from three patients with red blood cell pyruvate kinase deficiency.
Anemia, Hemolytic
Biochemical characterization of four new erythrocyte pyruvate kinase variants.
Anemia, Hemolytic
Biochemical characterization of three mutant isozymes of erythrocyte pyruvate kinase: PK-"Gainesville," PK-"San Juan," and PK-"Cape Canaveral".
Anemia, Hemolytic
Biphasic reaction kinetics in an anomalous isozyme of erythrocyte pyruvate kinase.
Anemia, Hemolytic
Calculation of surface area and volume of human erythrocytes from scanning electron micrographs.
Anemia, Hemolytic
Canine erythrocyte pyruvate kinase. II. Properties of abnormal enzyme associated with hemolytic anemia in the Basenji dog.
Anemia, Hemolytic
Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency.
Anemia, Hemolytic
Chronic haemolytic anaemia because of pyruvate kinase (PK) deficiency in a child heterozygous for haemoglobin S and no clinical features of sickle cell disease.
Anemia, Hemolytic
Chronic haemolytic anaemia in two patients heterozygous for erythrocyte pyruvate kinase deficiency. Electrofocusing and immunological studies of erythrocyte and liver pyruvate kinase.
Anemia, Hemolytic
Clinically relevant gene editing in hematopoietic stem cells for the treatment of pyruvate kinase deficiency.
Anemia, Hemolytic
Comorbidities and complications in adults with pyruvate kinase deficiency.
Anemia, Hemolytic
Congenital non-spherocytic haemolytic anaemia variants with primary and secondary pyruvate kinase deficiency. I. Erythrokinetic patterns.
Anemia, Hemolytic
Congenital non-spherocytic haemolytic anaemia variants with primary and secondary pyruvate kinase deficiency. II. Enzymatic studies.
Anemia, Hemolytic
Consensus document for the diagnosis and treatment of pyruvate kinase deficiency.
Anemia, Hemolytic
Cord blood transplantation in a young child with pyruvate kinase deficiency.
Anemia, Hemolytic
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia.
Anemia, Hemolytic
Delayed onset of hemolytic anemia in CBA-Pk-1slc/Pk-1slc mice with a point mutation of the gene encoding red blood cell type pyruvate kinase.
Anemia, Hemolytic
Determination of erythrocyte pyruvate kinase deficiency in Basenjis with chronic hemolytic anemia.
Anemia, Hemolytic
Development of an Automated Enzymatic Method to Quantify Pyruvate Kinase in Red Blood Cells.
Anemia, Hemolytic
Diagnosis of pyruvate kinase deficiency in a transfusion-dependent patient with severe hemolytic anemia.
Anemia, Hemolytic
Disruption of a novel regulatory element in the erythroid-specific promoter of the human PKLR gene causes severe pyruvate kinase deficiency.
Anemia, Hemolytic
Dyserythropoiesis in a child with pyruvate kinase deficiency and coexistent unilateral multicystic dysplastic kidney.
Anemia, Hemolytic
Effect of riboflavin treatment on human red cell pyruvate kinase deficiency.
Anemia, Hemolytic
Eight novel mutations and consequences on mRNA and protein level in pyruvate kinase-deficient patients with nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Elevated pyruvate kinase activity in patients with hemolytic anemia due to red cell pyruvate kinase "deficiency".
Anemia, Hemolytic
Enzymatic pattern of glucose metabolic pathways in pyruvate kinase-deficient erythrocytes.
Anemia, Hemolytic
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. I. Cell morphology.
Anemia, Hemolytic
Erythrocyte pyruvate kinase deficiency in non-spherocytic hemolytic anemia: a system of multiple genetic markers?
Anemia, Hemolytic
Erythrocyte pyruvate kinase deficiency mutation identified in multiple breeds of domestic cats.
Anemia, Hemolytic
ERYTHROCYTE PYRUVATE KINASE DEFICIENCY RESULTING IN CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Anemia, Hemolytic
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
Anemia, Hemolytic
Erythrocyte pyruvate kinase deficiency: 2015 status report.
Anemia, Hemolytic
Erythrocyte pyruvate kinase- and glucose phosphate isomerase deficiency: perturbation of glycolysis by structural defects and functional alterations of defective enzymes and its relation to the clinical severity of chronic hemolytic anemia.
Anemia, Hemolytic
Erythrocytic pyruvate kinase deficiency and hemolytic anemia inherited as a dominant trait.
Anemia, Hemolytic
Erythrocytic Pyruvate Kinase Mutations Causing Hemolytic Anemia, Osteosclerosis, and Secondary Hemochromatosis in Dogs.
Anemia, Hemolytic
Erythropoiesis: Pyruvate Kinase Deficiency which Causes Nonspherocytic Hemolytic Anemia: The Gene and its Mutations.
Anemia, Hemolytic
Erythropoietin in the treatment of iron overload in a patient with hemolytic anemia and pyruvate kinase deficiency.
Anemia, Hemolytic
Estimating the prevalence of pyruvate kinase deficiency from the gene frequency in the general white population.
Anemia, Hemolytic
Ex vivo analysis of aberrant splicing induced by two donor site mutations in PKLR of a patient with severe pyruvate kinase deficiency.
Anemia, Hemolytic
Extreme deficiency of L-type pyruvate kinase with moderate clinical expression.
Anemia, Hemolytic
Familial haemolytic anaemia due to pyruvate kinase deficiency.
Anemia, Hemolytic
Familial hemolytic anemia resulting from an abnormal red blood cell pyruvate kinase.
Anemia, Hemolytic
Fifteen novel mutations in PKLR associated with pyruvate kinase (PK) deficiency: structural implications of amino acid substitutions in PK.
Anemia, Hemolytic
First reported case of prenatal diagnosis for pyruvate kinase deficiency in a Chinese family.
Anemia, Hemolytic
Five unknown mutations in the LR pyruvate kinase gene associated with severe hereditary nonspherocytic haemolytic anaemia in France.
Anemia, Hemolytic
Frame shift mutation, exon skipping, and a two-codon deletion caused by splice site mutations account for pyruvate kinase deficiency.
Anemia, Hemolytic
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Anemia, Hemolytic
Genetic test for pyruvate kinase deficiency of Basenjis.
Anemia, Hemolytic
Glucose-6-phosphate dehydrogenase and red cell pyruvate kinase deficiency in neonatal jaundice cases in egypt.
Anemia, Hemolytic
Haematological parameters and altered erythrocyte metabolism in anaemic dogs.
Anemia, Hemolytic
Haemolytic anaemia due to pyruvate kinase deficiency.
Anemia, Hemolytic
Haemolytic anaemia in Basenji dogs. 2. Partial deficiency of erythrocyte pyruvate kinase (PK; EC 2.7.1.40) in heterozygous carriers.
Anemia, Hemolytic
Haemolytic anaemia with hereditary pyruvate kinase instability developing acute leukaemia.
Anemia, Hemolytic
Health-Related Quality of Life and Fatigue in Children and Adults with Pyruvate Kinase Deficiency.
Anemia, Hemolytic
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Anemia, Hemolytic
Hemochromatosis and pyruvate kinase deficiency. Report of a case and review of the literature.
Anemia, Hemolytic
Hemolytic anemia and pyruvate kinase deficiency in pregnancy.
Anemia, Hemolytic
Hemolytic anemia due to pyruvate kinase deficiency: characterization of the enzymatic activity from eight patients.
Anemia, Hemolytic
Hemolytic anemia in pregnancy associated with erythrocyte pyruvate kinase deficiency.
Anemia, Hemolytic
Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma.
Anemia, Hemolytic
Hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency: A biochemical, genetic and clinical overview.
Anemia, Hemolytic
Hereditary hemolytic anemia caused by diverse point mutations of pyruvate kinase gene found in Japan and Hong Kong.
Anemia, Hemolytic
Hereditary nonspherocytic hemolytic anemia due to pyruvate kinase deficiency: a prevalence study in Quebec (Canada).
Anemia, Hemolytic
Heterogeneity of erythrocyte pyruvate kinase deficiency and related metabolic disorders in patients with hematological diseases.
Anemia, Hemolytic
Heterozygous pyruvate kinase deficiency and severe hemolytic anemia in a pregnant woman with concomitant, glucose-6-phosphate dehydrogenase deficiency.
Anemia, Hemolytic
Homozygous pyruvate kinase deficiency in Hong Kong ethnic minorities.
Anemia, Hemolytic
How we manage patients with pyruvate kinase deficiency.
Anemia, Hemolytic
Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Identification and in silico characterization of a novel PKLR genotype in a Turkish newborn.
Anemia, Hemolytic
Identification of a novel promoter mutation in the human pyruvate kinase (PK) LR gene of a patient with severe haemolytic anaemia.
Anemia, Hemolytic
Identification of an erythrocyte pyruvate kinase variant in a family from Latium with non-spherocytic congenital haemolytic anaemia.
Anemia, Hemolytic
Impaired erythrocyte phosphoribosylpyrophosphate formation in hemolytic anemia due to pyruvate kinase deficiency.
Anemia, Hemolytic
Improving the laboratory diagnosis of pyruvate kinase deficiency.
Anemia, Hemolytic
In silico-screening approaches for lead generation: identification of novel allosteric modulators of human-erythrocyte pyruvate kinase.
Anemia, Hemolytic
In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach.
Anemia, Hemolytic
Inherited pyruvate kinase deficiency and normal haematologic values in Australian Basenji dogs.
Anemia, Hemolytic
Inhibition of the pentose phosphate shunt by 2,3-diphosphoglycerate in erythrocyte pyruvate kinase deficiency.
Anemia, Hemolytic
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Anemia, Hemolytic
Laboratory studies of erythrocytic pyruvate kinase deficiency. Pathogenesis of the hemolysis.
Anemia, Hemolytic
Life-threatening nonspherocytic hemolytic anemia in a patient with a null mutation in the PKLR gene and no compensatory PKM gene expression.
Anemia, Hemolytic
Low substrate affinity of pyruvate kinase variant (PK Sapporo) caused by a single amino acid substitution (426 Arg-->Gln) associated with hereditary hemolytic anemia.
Anemia, Hemolytic
Malaria: looking for selection signatures in the human PKLR gene region.
Anemia, Hemolytic
Management of pyruvate kinase deficiency in children and adults.
Anemia, Hemolytic
Membrane-localized pyruvate kinase of red blood cells in hemolytic anemia associated with pyruvate kinase deficiency.
Anemia, Hemolytic
Mining for allosteric information: Natural mutations and positional sequence conservation in pyruvate kinase.
Anemia, Hemolytic
Molecular analysis of 29 pyruvate kinase-deficient patients from central Europe with hereditary hemolytic anemia.
Anemia, Hemolytic
Molecular characterization of the PK-LR gene in pyruvate kinase deficient Spanish patients. Red Cell Pathology Group of the Spanish Society of Haematology (AEHH).
Anemia, Hemolytic
Molecular characterization of the PK-LR gene in sixteen pyruvate kinase-deficient patients.
Anemia, Hemolytic
Molecular heterogeneity of pyruvate kinase deficiency.
Anemia, Hemolytic
Molecular modelling of human red blood cell pyruvate kinase: structural implications of a novel G1091 to a mutation causing severe nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Mutations in pyruvate kinase.
Anemia, Hemolytic
Mutations in the R-type pyruvate kinase gene and altered enzyme kinetic properties in patients with hemolytic anemia due to pyruvate kinase deficiency.
Anemia, Hemolytic
Nonspherocytic haemolytic anaemia and severe jaundice in a newborn with partial pyruvate kinase deficiency.
Anemia, Hemolytic
Novel mutations and structural implications in R-type pyruvate kinase-deficient patients from Southern Italy.
Anemia, Hemolytic
Novel mutations associated with pyruvate kinase deficiency in Brazil.
Anemia, Hemolytic
Patient with pyruvate kinase deficiency developed acute myelogenous leukemia.
Anemia, Hemolytic
Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers.
Anemia, Hemolytic
PK Mondor: prenatal diagnosis of a frameshift mutation in the LR pyruvate kinase gene associated with severe hereditary non-spherocytic haemolytic anaemia.
Anemia, Hemolytic
PK-LR gene mutations in pyruvate kinase deficient Portuguese patients.
Anemia, Hemolytic
Point mutations in the L-type pyruvate kinase gene of two children with hemolytic anemia caused by pyruvate kinase deficiency.
Anemia, Hemolytic
Prevalence of erythrocyte pyruvate kinase deficiency and normal values of enzyme in a Turkish population.
Anemia, Hemolytic
Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Pyruvate kinase deficiency anaemia in a Basenji dog.
Anemia, Hemolytic
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
Anemia, Hemolytic
Pyruvate kinase deficiency causing hemolytic anemia with secondary hemochromatosis in a Cairn terrier.
Anemia, Hemolytic
Pyruvate kinase deficiency complicating pregnancy.
Anemia, Hemolytic
Pyruvate kinase deficiency hemolytic anemia: enzymatic characterization studies in twelve patients.
Anemia, Hemolytic
Pyruvate kinase deficiency hemolytic anemia: two successful pregnancy outcomes.
Anemia, Hemolytic
Pyruvate kinase deficiency in children.
Anemia, Hemolytic
Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria.
Anemia, Hemolytic
Pyruvate kinase deficiency of mice associated with nonspherocytic hemolytic anemia and cure of the anemia by marrow transplantation without host irradiation.
Anemia, Hemolytic
Pyruvate Kinase Deficiency which Causes Nonspherocytic Hemolytic Anemia: The Gene and its Mutations.
Anemia, Hemolytic
Pyruvate kinase deficiency: characterization of two new genetic variants.
Anemia, Hemolytic
Pyruvate kinase deficiency: correlation between enzyme activity, extent of hemolytic anemia and protection against malaria in independent mouse mutants.
Anemia, Hemolytic
Pyruvate kinase deficiency: the genotype-phenotype association.
Anemia, Hemolytic
PYRUVATE KINASE DEFICIENT HEMOLYTIC ANEMIA IN AN AMISH ISOLATE.
Anemia, Hemolytic
Pyruvate kinase deficient hemolytic anemia in the Northern Irish population.
Anemia, Hemolytic
Pyruvate kinase Greensboro. A four-generation study of a high K0.5s (phosphoenolpyruvate) variant.
Anemia, Hemolytic
Pyruvate kinase isozyme (PK-Greenville) with defective allosteric activation by fructose-1,6-diphosphate: the role of F-1,6-P modulation in normal erythrocyte metabolism.
Anemia, Hemolytic
Quinine protects pyruvate-kinase deficient red cells from dehydration.
Anemia, Hemolytic
Red blood cell age, pyruvate kinase activity, and insulin receptors. Evidence that monocytes and RBCs may behave differently.
Anemia, Hemolytic
Red Blood Cell Enzyme Disorders.
Anemia, Hemolytic
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Anemia, Hemolytic
Red blood cell PK deficiency: An update of PK-LR gene mutation database.
Anemia, Hemolytic
Red cell pyruvate kinase deficiency in Southern Sardinia.
Anemia, Hemolytic
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene.
Anemia, Hemolytic
Red cell pyruvate kinase deficiency: adverse effect of oral contraceptives.
Anemia, Hemolytic
Red cell pyruvate kinase deficiency: from genetics to clinical manifestations.
Anemia, Hemolytic
Red cell pyruvate kinase deficiency: molecular and clinical aspects.
Anemia, Hemolytic
Rescue of Pyruvate Kinase Deficiency in Mice by Gene Therapy Using the Human Isoenzyme.
Anemia, Hemolytic
Residual pyruvate kinase activity in PKLR deficient erythroid precursors of a patient suffering from severe haemolytic anaemia.
Anemia, Hemolytic
Retrovirus-mediated gene transfer of human pyruvate kinase (PK) cDNA into murine hematopoietic cells: implications for gene therapy of human PK deficiency.
Anemia, Hemolytic
RLS with PLMS in a child with hemolytic anemia caused by pyruvate kinase deficiency.
Anemia, Hemolytic
Roentgenographic manifestations of pyruvate kinase deficiency hemolytic anemia.
Anemia, Hemolytic
Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.
Anemia, Hemolytic
Sequestration and destruction of reticulocyte in the spleen in pyruvate kinase deficiency hereditary nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Severe canine hereditary hemolytic anemia treated by nonmyeloablative marrow transplantation.
Anemia, Hemolytic
Severe H1N1-associated acute respiratory failure in immunocompromised children.
Anemia, Hemolytic
Severe hemolytic anemia in a Vietnamese family, associated with novel mutations in the gene encoding for pyruvate kinase.
Anemia, Hemolytic
Severe hereditary haemolytic anaemica in dogs treated by marrow trasplantation.
Anemia, Hemolytic
Severe pyruvate kinase deficiency anemia. A case report.
Anemia, Hemolytic
Simultaneous inheritance of mutant isoenzymes of erythrocyte pyruvate kinase associated with chronic haemolytic anaemia.
Anemia, Hemolytic
Single port robotic splenectomy for pyruvate kinase deficiency in a five-year-old patient, a case report of a surgical first.
Anemia, Hemolytic
Six previously undescribed pyruvate kinase mutations causing enzyme deficiency.
Anemia, Hemolytic
Spectrum of novel mutations in the human PKLR gene in pyruvate kinase-deficient Indian patients with heterogeneous clinical phenotypes.
Anemia, Hemolytic
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Study of the molecular defects in pyruvate kinase deficient patients affected by nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusiondependent pyruvate kinase deficiency anemia.
Anemia, Hemolytic
Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency.
Anemia, Hemolytic
Successful Liver Transplants for Liver Failure Associated With Pyruvate Kinase Deficiency.
Anemia, Hemolytic
Tanaka KR, Valentine WN, Miwa S. Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia. Blood. 1962;19(3):267-295.
Anemia, Hemolytic
The burden of disease in pyruvate kinase deficiency: Patients' perception of the impact on health-related quality of life.
Anemia, Hemolytic
The clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study.
Anemia, Hemolytic
The influence of magnesium ions on pyruvate kinase-deficient red blood cells.
Anemia, Hemolytic
The molecular basis of canine pyruvate kinase deficiency.
Anemia, Hemolytic
The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency.
Anemia, Hemolytic
The variable manifestations of disease in pyruvate kinase deficiency and their management.
Anemia, Hemolytic
Three cases of hemolytic anemia with erythrocyte pyruvate kinase deficiency in Alberta.
Anemia, Hemolytic
Three pyruvate kinase variants with increased affinity for PEP.
Anemia, Hemolytic
Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency.
Anemia, Hemolytic
Two homozygous cases of erythrocyte pyruvate kinase (PK) deficiency in Japan: PK Sendai and PK Shinshu.
Anemia, Hemolytic
Two Novel Missense Mutations and a 5bp Deletion in the Erythroid-Specific Promoter of the PKLR Gene in Two Unrelated Patients With Pyruvate Kinase Deficient Transfusion-Dependent Chronic Nonspherocytic Hemolytic Anemia.
Anemia, Hemolytic
[A case of congenital non-spherocytic hemolytic anemia caused by enzyme deficiency in pyruvate kinase]
Anemia, Hemolytic
[A case of nonspherocytic hemolytic anemia caused by deficient activity of erythrocyte pyruvate kinase]
Anemia, Hemolytic
[Anomalies of glycolysis during hemolytic anemia due to deficiency of pyruvate kinase in the erythrocytes]
Anemia, Hemolytic
[Apropos of 3 new types of hemolytic anemia in children. Infantile pyknocytosis. Familial hemolytic anemia with erythrocytic inclusions and pigmenturia. Anemia caused by a deficiency of pyruvate kinase.]
Anemia, Hemolytic
[Chronic non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency in a Costa Rican family carrying hemoglobin C disease]
Anemia, Hemolytic
[Congenital non spherocytic hemolytic anemia caused by pyruvate kinase abnormalities]
Anemia, Hemolytic
[Congenital nonspherocytic hemolytic anemia with deficiency of erythrocytic pyruvate kinase]
Anemia, Hemolytic
[Constitutional hemolytic anemia due to pyruvate kinase deficiency. Study of 2 families]
Anemia, Hemolytic
[Defects in erythrocyte glycolysis enzymes as the cause of nonspherocytic hemolytic anemia]
Anemia, Hemolytic
[Deficiency of pyruvate kinase in erythrocytes: biochemical studies. Preliminary communication]
Anemia, Hemolytic
[Efficacy of splenectomy in 2 cases of hemolytic anemia caused by pyruvate kinase deficiency]
Anemia, Hemolytic
[Ektacytometric determination of the deformability of red blood cells in hemolytic anemia with pyruvate kinase deficiency]
Anemia, Hemolytic
[Erythrocyte pyruvate kinase deficiency: hemolytic anemia in a heterozygote]
Anemia, Hemolytic
[Erythrocyte pyruvate kinase deficiency: hemolytic anemia in single and double heterozygotes]
Anemia, Hemolytic
[Erythrocytic pyruvate kinase deficiency accompanied by a severe neonatal hemolytic anemia. Family study and biochemical characterization of the enzyme]
Anemia, Hemolytic
[Erythrocytic pyruvate kinase. II. Enzymatic heterogeneity of deficiencies. Studies concerning 28 cases with congenital hemolytic anemia]
Anemia, Hemolytic
[Familial chronic jaundice caused by nonspherocytic hemolytic anemia, with increase of erythrocyte pyruvate kinase]
Anemia, Hemolytic
[From gene to disease; hereditary non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency]
Anemia, Hemolytic
[Glucocorticoid-induced effect of erythropoietin in haemolytic anaemia with uraemia and red cell enzyme deficiency (author's transl)]
Anemia, Hemolytic
[Haemolytic anaemia an leg ulcers due to pyruvate kinase deficiency. report of the second venezuelan family (author's transl)]
Anemia, Hemolytic
[Haemolytic anaemia due to hereditary defect of erythrocyte pyruvate kinase. Clinical, familial, and biological study of ten cases (author's transl)]
Anemia, Hemolytic
[Hemolytic anemia caused by pyruvate kinase deficiency and pregnancy]
Anemia, Hemolytic
[Hereditary haemolytic anaemia due to pyruvate kinase deficiency. Prognosis of neonatal forms (author's transl)]
Anemia, Hemolytic
[Inherited hemolytic anemia due to pyruvate kinase deficiency: II. Density-layer centrifugation of erythrocytes (author's transl)]
Anemia, Hemolytic
[Iron overload in congenital hemolytic anemia caused by pyruvate kinase deficiency. A major late complication]
Anemia, Hemolytic
[Metabolic studies in a family with 3 cases of congenital non-spherocytic hemolytic anemia with a pyruvate kinase deficiency]
Anemia, Hemolytic
[Molecular study of red cell pyruvate kinase deficiency in 15 patients with chronic hemolytic anemia. Group of Erythropathology of Hematology and hemotherapy Association of Spain (HHAS)]
Anemia, Hemolytic
[Non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency]
Anemia, Hemolytic
[Nonspherocytic haemolytic anaemia due to inborn pyruvate kinase disorder (variant PK--type 1) in a Slovak family (author's transl)]
Anemia, Hemolytic
[Nonspherocytic hemolytic anemia in pyruvate kinase deficiency]
Anemia, Hemolytic
[Physico-chemical and kinetic properties of pyruvate kinase in erythrocytes in enzymopathic hemolytic anemia]
Anemia, Hemolytic
[Pyruvate kinase deficiency ass3ciated with nonspherocytic hemolytic anemia. Biochemical hematological study of 3 cases]
Anemia, Hemolytic
[PYRUVATE KINASE DEFICIENCY HEREDITARY NONSPHEROCYTIC HEMOLYTIC ANEMIA. REPORT OF TWO CASES IN A JAPANESE FAMILY AND REVIEW OF LITERATURE.]
Anemia, Hemolytic
[Pyruvate kinase deficiency in hereditary, non-spherocytic hemolytic anemia]
Anemia, Hemolytic
[Pyruvate kinase deficiency, infectious mononucleosis, hemolytic anemia with cold autoantibodies and massive splenic infarction]
Anemia, Hemolytic
[Splenectomized pyruvate kinase deficiency hemolytic anemia with positive Coombs' test: report of a case with family study (author's transl)]
Anemia, Hemolytic
[The clinical and laboratory characteristics of congenital pyruvate kinase deficiency].
Anemia, Hemolytic
[Vascular complications in a case of hemolytic anemia due to pyruvate kinase deficiency]
Anemia, Hemolytic, Autoimmune
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
Anemia, Hemolytic, Autoimmune
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Anemia, Hemolytic, Autoimmune
Rapid flow cytometric test using eosin-5-maleimide for diagnosis of red blood cell membrane disorders.
Anemia, Hemolytic, Autoimmune
Serum ferritin in patients with various haemolytic disorders.
Anemia, Hemolytic, Autoimmune
[The modified "pink test" in the diagnosis of hereditary spherocytosis]
Anemia, Hemolytic, Congenital
A case of hereditary spherocytosis misdiagnosed as pyruvate kinase deficient hemolytic anemia.
Anemia, Hemolytic, Congenital
A Case With Pyruvate Kinase Deficiency Remarkably Sensitive to Heat.
Anemia, Hemolytic, Congenital
A family case of pyruvate kinase variant, PK 'Nichinan'.
Anemia, Hemolytic, Congenital
A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency.
Anemia, Hemolytic, Congenital
Canine erythrocyte pyruvate kinase. II. Properties of abnormal enzyme associated with hemolytic anemia in the Basenji dog.
Anemia, Hemolytic, Congenital
Case report: pyruvate kinase deficiency.
Anemia, Hemolytic, Congenital
cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia.
Anemia, Hemolytic, Congenital
Congenital hemolytic anemia in the Basenji dog due to erythrocyte pyruvate kinase deficiency.
Anemia, Hemolytic, Congenital
Erythrocyte pyruvate kinase deficiency in the Ohio Amish: origin and characterization of the mutant enzyme.
Anemia, Hemolytic, Congenital
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
Anemia, Hemolytic, Congenital
Functionally abnormal pyruvate kinase in congenital hemolytic anemia.
Anemia, Hemolytic, Congenital
Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency.
Anemia, Hemolytic, Congenital
Hereditary hemolytic anemia caused by diverse point mutations of pyruvate kinase gene found in Japan and Hong Kong.
Anemia, Hemolytic, Congenital
Identical point mutations of the R-type pyruvate kinase (PK) cDNA found in unrelated PK variants associated with hereditary hemolytic anemia.
Anemia, Hemolytic, Congenital
Increased expression of a novel leukocytic factor in patients with hemolytic anemia.
Anemia, Hemolytic, Congenital
Intra-erythrocytary enzymes before and after splenectomy.
Anemia, Hemolytic, Congenital
Low substrate affinity of pyruvate kinase variant (PK Sapporo) caused by a single amino acid substitution (426 Arg-->Gln) associated with hereditary hemolytic anemia.
Anemia, Hemolytic, Congenital
Molecular aspects of erythroenzymopathies associated with hereditary hemolytic anemia.
Anemia, Hemolytic, Congenital
Molecular basis of erythroenzymopathies associated with hereditary hemolytic anemia: tabulation of mutant enzymes.
Anemia, Hemolytic, Congenital
Molecular characterization of PK-LR gene in pyruvate kinase-deficient Italian patients.
Anemia, Hemolytic, Congenital
Mutations in the pyruvate kinase L gene in patients with hereditary hemolytic anemia.
Anemia, Hemolytic, Congenital
Prevalence of erythrocyte pyruvate kinase deficiency and normal values of enzyme in a Turkish population.
Anemia, Hemolytic, Congenital
Pyruvate kinase "Göttingen 1,2": congenital hemolytic anemia, evidence of double heterozygosity, and lack of enzyme cooperativity.
Anemia, Hemolytic, Congenital
Pyruvate kinase deficiency and severe congenital hemolytic anemia in a double heterozygous patient with paternal transmission of an early germ-line de novo mutation.
Anemia, Hemolytic, Congenital
Red cell enzymopathies as a model of inborn errors of metabolism.
Anemia, Hemolytic, Congenital
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency.
Anemia, Hemolytic, Congenital
Six novel variants in the PKLR gene associated with pyruvate kinase deficiency in Argentinian patients.
Anemia, Hemolytic, Congenital
[Congenital hemolytic anemia caused by pyruvate kinase variants (PK 'Kasumi')]
Anemia, Hemolytic, Congenital
[Erythrocytic pyruvate kinase. II. Enzymatic heterogeneity of deficiencies. Studies concerning 28 cases with congenital hemolytic anemia]
Anemia, Hemolytic, Congenital
[Hereditary hemolytic anemia due to functionally abnormal pyruvate kinase. Report of a case (author's transl)]
Anemia, Hemolytic, Congenital
[HEREDITARY HEMOLYTIC ANEMIAS WITH PYRUVATE KINASE DEFICIENCY.]
Anemia, Hemolytic, Congenital
[Iron overload in congenital hemolytic anemia caused by pyruvate kinase deficiency. A major late complication]
Anemia, Hemolytic, Congenital
[Nonspherocytic congenital hemolytic anemia induced by a pyruvate kinase deficiency. Presentation of a clinical case]
Anemia, Hemolytic, Congenital
[Pathophysiology and laboratory tests of hemolytic anemia: with special reference to erythroenzymopathies]
Anemia, Hemolytic, Congenital
[Pyruvate kinase deficiency hereditary hemolytic anemia (author's transl)]
Anemia, Hemolytic, Congenital Nonspherocytic
ERYTHROCYTE PYRUVATE KINASE DEFICIENCY RESULTING IN CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Anemia, Hemolytic, Congenital Nonspherocytic
Management of pyruvate kinase deficiency in children and adults.
Anemia, Hemolytic, Congenital Nonspherocytic
The influence of magnesium ions on pyruvate kinase-deficient red blood cells.
Anemia, Hemolytic, Congenital Nonspherocytic
[Congenital nonspherocytic hemolytic anemia with deficiency of erythrocytic pyruvate kinase]
Anemia, Iron-Deficiency
Enzymic stability of red cells in iron deficiency anaemia. I. Stability of adenosine triphosphate and activity of pyruvate kinase.
Anemia, Iron-Deficiency
Spontaneous splenic rupture in primary cytomegalovirus infection.
Anemia, Iron-Deficiency
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
Anemia, Macrocytic
Acute myeloblastic leukemia following non-Hodgkin lymphoma in an adolescent. A report of a case with preleukemic syndrome, and review of the literature.
Anemia, Macrocytic
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
Anemia, Neonatal
[Prenatal diagnosis of homozygous pyruvate kinase deficiency]
Anemia, Pernicious
[The importance of determination of ferritin levels in erythrocytes]
Anemia, Refractory
Mechanisms of the acquired erythrocyte enzyme deficiencies in blood diseases.
Anemia, Refractory
[Enzyme deficiencies of blood cells in bone marrow insufficiency (author's transl]
Anemia, Sickle Cell
A new sickle cell disease phenotype associating Hb S trait, severe pyruvate kinase deficiency (PK Conakry), and an alpha2 globin gene variant (Hb Conakry).
Anemia, Sickle Cell
Chronic haemolytic anaemia because of pyruvate kinase (PK) deficiency in a child heterozygous for haemoglobin S and no clinical features of sickle cell disease.
Anemia, Sickle Cell
Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy.
Anemia, Sickle Cell
Fragility of abnormal erythrocytes evaluated by response to shear stress.
Anemia, Sickle Cell
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Anemia, Sickle Cell
How I do in front of an hemolytic anemia of unknown etiology?
Anemia, Sickle Cell
Increased IgG molecules bound to the surface of red blood cells of patients with sickle cell anemia.
Anemia, Sickle Cell
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Anemia, Sickle Cell
Red blood cell disorders in Rwandese neonates: screening for sickle cell disease and glucose-6-phosphate dehydrogenase deficiency.
Anemia, Sickle Cell
Relationship of density distribution and pyruvate kinase electrophoretic pattern of erythrocytes in sickle cell diseases and other disorders.
Anemia, Sickle Cell
Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters.
Anemia, Sickle Cell
Sickle cell disease in a carrier with pyruvate kinase deficiency.
Anemia, Sideroblastic
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Anemia, Sideroblastic
Hepcidin and Anemia: A Tight Relationship.
Anemia, Sideroblastic
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Anemia, Sideroblastic
Targeted next generation sequencing for the diagnosis of patients with rare congenital anemias.
Angina Pectoris
A kindred with red cell pyruvate kinase deficiency.
Arthritis, Psoriatic
Granulocyte pyruvate kinase in psoriasis vulgaris and psoriasis arthropathica.
Arthritis, Rheumatoid
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Asthma
Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma.
Astrocytoma
Cellular expression of K-type pyruvate kinase in normal and neoplastic human tissues.
Astrocytoma
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Astrocytoma
Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism.
Astrocytoma
Study of pyruvate kinase activity in human astrocytomas - Alanine-inhibition test revisted.
Ataxia
The double dealing of cyclin D1.
Atherosclerosis
T-cell-derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2.
Autoimmune Diseases
Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders.
Babesiosis
Babesia rodhaini: the protective effect of pyruvate kinase deficiency in mice.
Bacterial Infections
Caffeine supplementation in diet mitigates Aeromonas hydrophila-induced impairment of the gill phosphotransfer network in grass carp Ctenopharyngodon idella.
Bacterial Infections
Involvement of the phosphoryl transfer network on cardiac energetic metabolism during Staphylococcus aureus infection and its association to disease pathophysiology.
Bacterial Infections
Ribosome-Amplified Metabolism, RAMBO, Measured by NMR Spectroscopy.
Barrett Esophagus
Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia.
beta-Thalassemia
31P NMR spectroscopy of erythrocytes in congenital hemolytic anemias: detection of heterogeneous erythrocyte populations and quantification of intracellular 2,3-diphosphoglycerate.
beta-Thalassemia
Fragility of abnormal erythrocytes evaluated by response to shear stress.
beta-Thalassemia
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
beta-Thalassemia
Hereditary Xerocytosis due to Mutations in PIEZO1 Gene Associated with Heterozygous Pyruvate Kinase Deficiency and Beta-Thalassemia Trait in Two Unrelated Families.
beta-Thalassemia
[Pyruvate kinase deficiency in a patient with beta-thalassemia]
beta-Thalassemia
[The importance of determination of ferritin levels in erythrocytes]
Bile Duct Neoplasms
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Biliary Tract Neoplasms
Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer.
Bloom Syndrome
Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme.
Bloom Syndrome
Dominant negative effect of novel mutations in pyruvate kinase-M2.
Bloom Syndrome
Dominant negative mutations affect oligomerisation of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy.
Brain Diseases
Correction to: Clinical approach to neurodegenerative disorders in childhood: an updated overview.
Brain Injuries
Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection.
Brain Neoplasms
Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
Brain Neoplasms
Pyruvate kinase in human brain tumours. Its significance in the treatment of gliomas.
Brain Neoplasms
Pyruvate kinase inhibition in the diagnosis of gliomas with an intermediate degree of malignancy.
Brain Neoplasms
The pyruvate kinase isoenzyme shift in human gliomas: a potential marker in the treatment of gliomas.
Brain Neoplasms
[Pyruvate kinase as a marker of human brain tumors]
Breast Diseases
Enzyme Kinetic Assay to Measure the Activity of Tumor M2 Pyruvate Kinase in Breast Cancer Patients.
Breast Diseases
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
Breast Neoplasms
Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation.
Breast Neoplasms
Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer.
Breast Neoplasms
Comparison of glycolytic enzyme and isoenzyme activity in breast cancers and dysplasia.
Breast Neoplasms
Comparison of pyruvate kinase variants from breast tumor and normal breast.
Breast Neoplasms
Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2.
Breast Neoplasms
Effect of pyruvate kinase M2-regulating aerobic glycolysis on chemotherapy resistance of estrogen receptor-positive breast cancer.
Breast Neoplasms
Enzyme Kinetic Assay to Measure the Activity of Tumor M2 Pyruvate Kinase in Breast Cancer Patients.
Breast Neoplasms
Expression and clinical significance of pyruvate kinase M2 in breast cancer: A protocol for meta-analysis and bioinformatics validation analysis.
Breast Neoplasms
Expression of multimolecular forms of pyruvate kinase in normal, benign, and malignant human breast tissue.
Breast Neoplasms
Glycolytic enzyme activities in breast cancer metastases.
Breast Neoplasms
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
Breast Neoplasms
Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPAR? in breast cancer pathophysiology.
Breast Neoplasms
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
Breast Neoplasms
High Expression of Pyruvate Kinase M2 is Associated with Chemosensitivity to Epirubicin and 5-Fluorouracil in Breast Cancer.
Breast Neoplasms
Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer.
Breast Neoplasms
Isozyme patterns of normal, benign, and malignant human breast tissues.
Breast Neoplasms
Kisspeptin 10 inhibits the Warburg effect in breast cancer through the Smad signaling pathway: both in vitro and in vivo.
Breast Neoplasms
Lapatinib Inhibits Breast Cancer Cell Proliferation by Influencing PKM2 Expression.
Breast Neoplasms
Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2.
Breast Neoplasms
Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.
Breast Neoplasms
NADH-Linked Metabolic Plasticity of MCF-7 Breast Cancer Cells Surviving in a Nutrient-Deprived Microenvironment.
Breast Neoplasms
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Breast Neoplasms
Overexpression of G6PD is associated with high risks of recurrent metastasis and poor progression-free survival in primary breast carcinoma.
Breast Neoplasms
Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells.
Breast Neoplasms
PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.
Breast Neoplasms
PKM2 promotes stemness of breast cancer cell by through Wnt/?-catenin pathway.
Breast Neoplasms
Plasma levels of HER-2/neu, tumor type M2 pyruvate kinase and its tyrosine-phosphorylated metabolite in advanced breast cancer.
Breast Neoplasms
Plasma TuM2-PK correlates with tumor size, CRP and CA 15-3 in metastatic breast carcinomas; short versus long term follow up study of the Egyptian breast cancer patients.
Breast Neoplasms
Prognostic significance of metabolic enzyme pyruvate kinase M2 in breast cancer: A meta-analysis.
Breast Neoplasms
Pyruvate kinase M2 interacts with mammalian sterile 20-like kinase 1 and inhibits tamoxifen-induced apoptosis in human breast cancer cells.
Breast Neoplasms
Short-chain lipid peroxidation products form covalent adducts with pyruvate kinase and inhibit its activity in vitro and in breast cancer cells.
Breast Neoplasms
The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer.
Breast Neoplasms
The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway.
Breast Neoplasms
Tumor M2 pyruvate kinase--determination in breast cancer patients receiving trastuzumab therapy.
Breast Neoplasms
Tumor type M2 pyruvate kinase expression in advanced breast cancer.
Breast Neoplasms
Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect.
Breast Neoplasms
[Biochemical behavior of pyruvate kinase, LDH, isocitrate dehydrogenase and malate dehydrogenase in breast carcinomas]
Bronchitis
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
Burkitt Lymphoma
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Carcinogenesis
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.
Carcinogenesis
Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia.
Carcinogenesis
Aspirin shares a short-term effect, inhibition of pyruvate kinase activity with tumor-promoting agents, but fails to promote rat liver carcinogenesis.
Carcinogenesis
Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment.
Carcinogenesis
Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer.
Carcinogenesis
Clinicopathological and prognostic significance of PKM2 protein expression in cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma.
Carcinogenesis
Diet-dependent carcinogenesis of pancreatic islets and liver in transgenic mice expressing oncogenes under the control of the L-type pyruvate kinase gene promoter.
Carcinogenesis
Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing.
Carcinogenesis
Establishment of renal proximal tubule cell lines by targeted oncogenesis in transgenic mice using the L-pyruvate kinase-SV40 (T) antigen hybrid gene.
Carcinogenesis
Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value.
Carcinogenesis
Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.
Carcinogenesis
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Carcinogenesis
Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review.
Carcinogenesis
Isoform switch of pyruvate kinase m1 indeed occurs but not to pyruvate kinase m2 in human tumorigenesis.
Carcinogenesis
Knockdown of PKM2 and GLS1 expression can significantly reverse oxaliplatin-resistance in colorectal cancer cells.
Carcinogenesis
Knockdown of PKM2 Suppresses Tumor Growth and Invasion in Lung Adenocarcinoma.
Carcinogenesis
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-?B pathway in HNSCC.
Carcinogenesis
LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2.
Carcinogenesis
Metabolic changes in cancer: beyond the Warburg effect.
Carcinogenesis
miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer.
Carcinogenesis
Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.
Carcinogenesis
Modifications of the expression of liver-specific and non-specific messenger RNAs during azo-dye hepatocarcinogenesis.
Carcinogenesis
Modulation of PKM activity affects the differentiation of TH17 cells.
Carcinogenesis
Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.
Carcinogenesis
No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis.
Carcinogenesis
Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis.
Carcinogenesis
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.
Carcinogenesis
Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression.
Carcinogenesis
Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.
Carcinogenesis
PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1? Secretion.
Carcinogenesis
PKM2 regulates Gli1 expression in hepatocellular carcinoma.
Carcinogenesis
PKM2-c-Myc-Survivin Cascade Regulates the Cell Proliferation, Migration, and Tamoxifen Resistance in Breast Cancer.
Carcinogenesis
Prolactin Inhibits Activity of Pyruvate Kinase M2 to Stimulate Cell Proliferation.
Carcinogenesis
Protein kinase function of pyruvate kinase M2 and cancer.
Carcinogenesis
Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma.
Carcinogenesis
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Carcinogenesis
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis.
Carcinogenesis
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Carcinogenesis
Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.
Carcinogenesis
Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis.
Carcinogenesis
SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma.
Carcinogenesis
Significant association of PKM2 and NQO1 proteins with poor prognosis in breast cancer.
Carcinogenesis
Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes.
Carcinogenesis
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Carcinogenesis
The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma.
Carcinogenesis
The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer.
Carcinogenesis
Verification of endometrial tissue biomarkers previously discovered using mass spectrometry-based proteomics by means of immunohistochemistry in a tissue microarray format.
Carcinogenesis
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma]
Carcinogenesis
[Changes in the isoenzymatic makeup of pyruvate kinase in hepatic carcinogenesis]
Carcinogenesis
[Pyruvate kinase isozymes in the liver during azo dye carcinogenesis]
Carcinoma
A study of PKM2, PFK-1, and ANT1 expressions in cervical biopsy tissues in China.
Carcinoma
Biochemical microanalysis of pyruvate kinase activity in preneoplastic and neoplastic liver lesions induced in rats by N-nitrosomorpholine.
Carcinoma
Carbohydrate metabolism in human renal clear cell carcinomas.
Carcinoma
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Carcinoma
Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK.
Carcinoma
Decreased pyruvate kinase M2 activity linked to cisplatin resistance in human gastric carcinoma cell lines.
Carcinoma
Determination of pyruvate kinase type tumor M2 in human renal cell carcinoma: a suitable tumor marker?
Carcinoma
Diagnostic and prognostic value of tumor M2-pyruvate kinase levels in patients with colorectal canhcer.
Carcinoma
Enzymatic characteristics of tubular adenomas and carcinomas of the large intestine.
Carcinoma
Evaluation of the Pyruvate Kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for cervical carcinoma.
Carcinoma
Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas.
Carcinoma
Fuzzy logic-based tumor marker profiles improved sensitivity of the detection of progression in small-cell lung cancer patients.
Carcinoma
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Carcinoma
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
Carcinoma
High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer.
Carcinoma
Identification of five candidate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines.
Carcinoma
Identification of potential canine mammary tumour cell biomarkers using proteomic approach: Differences in protein profiles among tumour and normal mammary epithelial cells by two-dimensional electrophoresis-based mass spectrometry.
Carcinoma
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling.
Carcinoma
Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma.
Carcinoma
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
Carcinoma
M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh's ESCC and promotes proliferation and migration of ESCC cells.
Carcinoma
Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK).
Carcinoma
Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells.
Carcinoma
Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.
Carcinoma
Plasma?derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.
Carcinoma
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Carcinoma
Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma.
Carcinoma
Pyruvate kinase in normal human thyroid tissue and thyroid neoplasms.
Carcinoma
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer.
Carcinoma
Pyruvate kinase isoenzymes in altered foci and carcinoma of rat liver.
Carcinoma
Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription.
Carcinoma
Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.
Carcinoma
Pyruvate Kinase M2 Knockdown Suppresses Migration, Invasion, and Epithelial-Mesenchymal Transition of Gastric Carcinoma via Hypoxia-Inducible Factor Alpha/B-Cell Lymphoma 6 Pathway.
Carcinoma
Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway.
Carcinoma
Pyruvate kinase type tumor M2 in urological malignancies.
Carcinoma
Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas.
Carcinoma
STIP1 down-regulation inhibits glycolysis by suppressing PKM2 and LDHA and inactivating the Wnt/?-catenin pathway in cervical carcinoma cells.
Carcinoma
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
Carcinoma
The Diagnostic Value of Pyruvate Kinase Isoenzyme Type M2 for Biliary Tract Carcinoma. A Systematic Review and Meta-Analysis.
Carcinoma
The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma.
Carcinoma
The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma.
Carcinoma
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Carcinoma
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Carcinoma
Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma.
Carcinoma
[Hybrid forms of the enzyme pyruvate kinase in human carcinomas]
Carcinoma
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
Carcinoma
[Relationship between gastric carcinoma and enzyme spectrum activity in gastric mucosal intestinal metaplasia]
Carcinoma
[Renal cell carcinoma. Immunohistological study to the expression of the inactive form of the pyruvate kinase]
Carcinoma
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
Carcinoma
[Tumor M2 pyruvate kinase in renal cell carcinoma. Studies of plasma in patients]
Carcinoma, Ductal
[Hybrid forms of the enzyme pyruvate kinase in human carcinomas]
Carcinoma, Ehrlich Tumor
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Carcinoma, Ehrlich Tumor
Effects of L-alanine and fructose (1,6-diphosphate) on pyruvate kinase from ehrlich ascites tumour cells.
Carcinoma, Ehrlich Tumor
Extraction of a factor from Ehrlich ascites tumor cells that increases the activity of the fetal isozyme of pyruvate kinase in mouse liver.
Carcinoma, Ehrlich Tumor
Interconversion phenomena between two kinetic forms of class a pyruvate kinase from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Interconvertible forms of class A pyruvate kinase from Ehrlich ascites tumour cells.
Carcinoma, Ehrlich Tumor
Pyruvate kinase from cytosolic fractions of the Ehrlich ascites tumour, normal mouse liver and skeletal muscle.
Carcinoma, Ehrlich Tumor
Pyruvate kinase isoenzymes in chromatin extracts of Ehrlich ascites tumour, Morris hepatoma 7777 and normal mouse and rat livers.
Carcinoma, Ehrlich Tumor
Stimulation of tumor-cell respiration by inhibitors of pyruvate kinase.
Carcinoma, Ehrlich Tumor
Synergistic effect of ammonium and potassium ions on pyruvate kinase from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
The inhibitory effect of L-cysteine and its derivatives on glycolysis in Ehrlich ascites tumour cells.
Carcinoma, Embryonal
Alterations of gene expression in endoderm differentiation of F9 teratocarcinoma cells.
Carcinoma, Embryonal
Molecular cloning of the complementary DNA for the mouse pyruvate kinase M-2 gene whose expression is dependent upon cell differentiation.
Carcinoma, Embryonal
Phosphofructokinase and pyruvate kinase in mouse embryonal carcinoma P19 cells in relation to growth and differentiation.
Carcinoma, Hepatocellular
2,3'4,4',5-Pentachlorobiphenyl induces hepatocellular carcinoma cell proliferation through pyruvate kinase M2-dependent glycolysis.
Carcinoma, Hepatocellular
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
Carcinoma, Hepatocellular
A comparison of the properties of pyruvate kinase from hepatoma 3924-A, normal liver and muscle.
Carcinoma, Hepatocellular
A new pyruvate kinase isozyme in hepatomas.
Carcinoma, Hepatocellular
Alteration in L-type pyruvate kinase gene expression is not associated with the LF-B1 mRNA level.
Carcinoma, Hepatocellular
cis-acting DNA elements regulating expression of the liver pyruvate kinase gene in hepatocytes and hepatoma cells. Evidence for tissue-specific activators and extinguisher.
Carcinoma, Hepatocellular
Comparison of pyruvate kinase variants from rat liver and Morris hepatoma 7777, obtained by an affinity chromatography on blue sepharose CL-6B.
Carcinoma, Hepatocellular
Coupling of glucose response element from L-type pyruvate kinase and G6Pase promoter enhances glucose responsive activity in hepatoma cells.
Carcinoma, Hepatocellular
CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation.
Carcinoma, Hepatocellular
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Carcinoma, Hepatocellular
Expression of hypoxia-inducible genes in tumor cells.
Carcinoma, Hepatocellular
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.
Carcinoma, Hepatocellular
Functional studies by site-directed mutagenesis on the role of Sp1 in the expression of the pyruvate kinase M and aldolase A genes.
Carcinoma, Hepatocellular
Gene expression in clonally derived cell lines produced by in vitro transformation of rat fetal hepatocytes: isolation of cell lines which retain liver-specific markers.
Carcinoma, Hepatocellular
Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism.
Carcinoma, Hepatocellular
Hepatic preneoplasia in hepatitis B virus transgenic mice.
Carcinoma, Hepatocellular
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma.
Carcinoma, Hepatocellular
Inhibition of Non-flux-Controlling Enzymes Deters Cancer Glycolysis by Accumulation of Regulatory Metabolites of Controlling Steps.
Carcinoma, Hepatocellular
Insulin regulates glucose consumption and lactate production through reactive oxygen species and pyruvate kinase M2.
Carcinoma, Hepatocellular
Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review.
Carcinoma, Hepatocellular
Isozyme differentiation of aldolase and pyruvate kinase in fetal, regenerating, preneoplastic, and malignant rat hepatocytes during culture.
Carcinoma, Hepatocellular
Isozymes of pyruvate kinase in liver and hepatomas of the rat.
Carcinoma, Hepatocellular
Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma.
Carcinoma, Hepatocellular
miR-4417 Targets Tripartite Motif-Containing 35 (TRIM35) and Regulates Pyruvate Kinase Muscle 2 (PKM2) Phosphorylation to Promote Proliferation and Suppress Apoptosis in Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Modifications of the expression of liver-specific and non-specific messenger RNAs during azo-dye hepatocarcinogenesis.
Carcinoma, Hepatocellular
Molecular cloning of cDNA sequences for rat M2-type pyruvate kinase and regulation of its mRNA.
Carcinoma, Hepatocellular
Multimolecular forms of pyruvate kinase. II. Purification of M 2 -type pyruvate kinase from Yoshida ascites hepatoma 130 cells and comparative studies on the enzymological and immunological properties of the three types of pyruvate kinases, L, M 1 , and M 2 .
Carcinoma, Hepatocellular
Overexpression of Pyruvate Kinase M2 in Tumor Tissues Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation.
Carcinoma, Hepatocellular
PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment.
Carcinoma, Hepatocellular
Pyruvate kinase isoenzymes in altered foci and carcinoma of rat liver.
Carcinoma, Hepatocellular
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Carcinoma, Hepatocellular
Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Pyruvate kinase of hepatoma Morris 5123: insensitivity to dietary changes.
Carcinoma, Hepatocellular
Rat hyperplastic hepatic nodules and primary hepatomas retaining abnormally high pyruvate kinase L type activity.
Carcinoma, Hepatocellular
Redox-regulated expression of glycolytic enzymes in resting and proliferating rat thymocytes.
Carcinoma, Hepatocellular
Regulation of genes for glycolytic enzymes in cultured rat hepatoma cell lines.
Carcinoma, Hepatocellular
Regulation of pyruvate kinase in Reuber H35 hepatoma cells by insulin and fructose.
Carcinoma, Hepatocellular
Retention of liver-type pyruvate kinase in cultured rat hepatoma cells.
Carcinoma, Hepatocellular
Role of the GLUT 2 glucose transporter in the response of the L-type pyruvate kinase gene to glucose in liver-derived cells.
Carcinoma, Hepatocellular
SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity.
Carcinoma, Hepatocellular
SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions.
Carcinoma, Hepatocellular
Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
The 5'-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex.
Carcinoma, Hepatocellular
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Carcinoma, Hepatocellular
The M1 and M2 subunits of rat pyruvate kinase are encoded by different messenger RNAs.
Carcinoma, Hepatocellular
TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.
Carcinoma, Hepatocellular
[Activities of several enzymes of glycolysis and of the glucose shunt in the Albert hepatoma of mouse (author's transl)]
Carcinoma, Hepatocellular
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma]
Carcinoma, Hepatocellular
[M2-type pyruvate kinase in the diagnosis of hepatocarcinoma--a pilot study]
Carcinoma, Hepatocellular
[Preparation and identification of a monoclonal antibody against recombinant human L-type pyruvate kinase N]
Carcinoma, Hepatocellular
[Properties of pyruvate kinase isozyme from rat ascites hepatoma 13 cells]
Carcinoma, Hepatocellular
[Pyruvate kinase activity in the liver of rats with induced tumors]
Carcinoma, Hepatocellular
[Pyruvate kinase of rat hepatoma, placenta and fetal liver]
Carcinoma, Hepatocellular
[Studies on the isozymes of pyruvate kinase in AH-13 hepatoma (author's transl)]
Carcinoma, Non-Small-Cell Lung
Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Comparison of the tumor markers tumor M2-PK, CEA, CYFRA 21-1, NSE and SCC in the diagnosis of lung cancer.
Carcinoma, Non-Small-Cell Lung
Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors.
Carcinoma, Non-Small-Cell Lung
Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro.
Carcinoma, Non-Small-Cell Lung
Limited Clinical Significance of Dimeric Form of Pyruvate Kinase as a Diagnostic and Prognostic Biomarker in Non-small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Serum tumour M2-pyruvate kinase as a biomarker for diagnosis and prognosis of early-stage non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo.
Carcinoma, Non-Small-Cell Lung
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Tumor M2 pyruvate kinase in diagnosis of nonsmall cell lung cancer: A meta-analysis based on Chinese population.
Carcinoma, Non-Small-Cell Lung
[The role of oncomarkers CEA, Cyfra-21, NSE, TU M2-PK in diagnosis and treatment of lung cancer]
Carcinoma, Non-Small-Cell Lung
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
Carcinoma, Non-Small-Cell Lung
[Tripartite-motif protein 25 and pyruvate kinase M2 protein expression in non-small cell lung cancer].
Carcinoma, Pancreatic Ductal
The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
Carcinoma, Renal Cell
Chaperon?mediated autophagy can promote proliferation and invasion of renal carcinoma cells and inhibit apoptosis through PKM2.
Carcinoma, Renal Cell
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Carcinoma, Renal Cell
Determination of pyruvate kinase type tumor M2 in human renal cell carcinoma: a suitable tumor marker?
Carcinoma, Renal Cell
Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma.
Carcinoma, Renal Cell
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
Carcinoma, Renal Cell
Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK).
Carcinoma, Renal Cell
Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma.
Carcinoma, Renal Cell
Pyruvate kinase type tumor M2 in urological malignancies.
Carcinoma, Renal Cell
The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma.
Carcinoma, Renal Cell
The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma.
Carcinoma, Renal Cell
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Carcinoma, Renal Cell
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Carcinoma, Renal Cell
Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma.
Carcinoma, Renal Cell
Value of tumor M2 (Tu M2-PK) in patients with renal carcinoma.
Carcinoma, Renal Cell
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
Carcinoma, Renal Cell
[Renal cell carcinoma. Immunohistological study to the expression of the inactive form of the pyruvate kinase]
Carcinoma, Renal Cell
[Tumor M2 pyruvate kinase in renal cell carcinoma. Studies of plasma in patients]
Carcinoma, Small Cell
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Carcinoma, Squamous Cell
An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate.
Carcinoma, Squamous Cell
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Carcinoma, Squamous Cell
High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer.
Carcinoma, Squamous Cell
Identification of five candidate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines.
Carcinoma, Squamous Cell
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling.
Carcinoma, Squamous Cell
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Carcinoma, Squamous Cell
Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.
Carcinoma, Transitional Cell
Pyruvate kinase type tumor M2 in urological malignancies.
Carcinoma, Transitional Cell
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Carcinosarcoma
[Lactate and pyruvate metabolism in the tissues of rats with Walker carcinosarcoma injected with oxythiamine]
Cardiomyopathy, Dilated
Assessment of PDK4 and TTN gene variants in 48 Doberman Pinschers with dilated cardiomyopathy.
Cell Transformation, Neoplastic
Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells.
Cholangiocarcinoma
Clinical significance of serum tumour M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma.
Cholangiocarcinoma
DNA Methylation of Cannabinoid Receptor Interacting Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination.
Cholangiocarcinoma
Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholangitis.
Cholangiocarcinoma
PKM2 upregulation promotes malignancy and indicates poor prognosis for intrahepatic cholangiocarcinoma.
Cholangiocarcinoma
Relationship between 18-F-fluoro-deoxy-D-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma.
Cholelithiasis
Treatment and long-term follow-up of extrahepatic biliary obstruction with bilirubin cholelithiasis in a Somali cat with pyruvate kinase deficiency.
Cholera
Independent regulation of pyruvate kinase expression by cyclic AMP and prostaglandin F2 alpha in mouse mastocytoma cells.
Cholestasis
Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency.
Cholestasis
Successful Liver Transplantation for Adolescent Patient With Pyruvate Kinase Deficiency-induced Cirrhosis.
Cholestasis
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Choriocarcinoma
Regulation of thyroid hormone receptor-mediated transcription by a cytosol protein.
Clonorchiasis
Sequence analysis and characterization of pyruvate kinase from Clonorchis sinensis, a 53.1-kDa homopentamer, implicated immune protective efficacy against clonorchiasis.
Coccidiosis
Intestinal injury caused by Eimeria spp. impairs the phosphotransfer network and gain weight in experimentally infected chicken chicks.
Colitis
SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1? Production and to Prevent DSS-Induced Colitis in Mice.
Colitis, Ulcerative
Accuracies of fecal calprotectin, lactoferrin, M2-pyruvate kinase, neopterin and zonulin to predict the response to infliximab in ulcerative colitis.
Colitis, Ulcerative
Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity.
Colitis, Ulcerative
Faecal calprotectin, lactoferrin, M2-pyruvate kinase and S100A12 in severe ulcerative colitis: a prospective multicentre comparison of predicting outcomes and monitoring response.
Colitis, Ulcerative
Fecal M2-pyruvate kinase (M2-PK): A novel marker of intestinal inflammation.
Colonic Neoplasms
Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis.
Colonic Neoplasms
Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.
Colonic Neoplasms
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Colonic Neoplasms
Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy.
Colonic Neoplasms
Diagnostic Value of Pyruvate Kinase Isoenzyme Type M2 in Colon Cancer Proven with Colonoscopy.
Colonic Neoplasms
Extracellular pyruvate kinase M2 facilitates cell migration by upregulating claudin-1 expression in colon cancer cells.
Colonic Neoplasms
Glucose-dependent transcriptional regulation of the human sucrase-isomaltase (SI) gene.
Colonic Neoplasms
PKM2 Expression as Biomarker for Resistance to Oxaliplatin-Based Chemotherapy in Colorectal Cancer.
Colonic Neoplasms
Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling.
Colonic Neoplasms
Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells.
Colonic Neoplasms
Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/?-catenin pathway in colon cancer cells.
Colonic Neoplasms
Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation.
Colonic Neoplasms
Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells.
Colorectal Neoplasms
A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines.
Colorectal Neoplasms
A systematic review and meta-analysis of the diagnostic accuracy of pyruvate kinase M2 isoenzymatic assay in diagnosing colorectal cancer.
Colorectal Neoplasms
Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells.
Colorectal Neoplasms
Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming.
Colorectal Neoplasms
Colon cancer screening: which non-invasive filter tests?
Colorectal Neoplasms
Colorectal cancer detection in an asymptomatic population: fecal immunochemical test for hemoglobin vs. fecal M2-type pyruvate kinase.
Colorectal Neoplasms
Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK.
Colorectal Neoplasms
Comparison of an established simple office-based immunological FOBT with fecal tumor pyruvate kinase type M2 (M2-PK) for colorectal cancer screening: prospective multicenter study.
Colorectal Neoplasms
Comparison of faecal M2-PK and FIT in a population-based bowel cancer screening cohort.
Colorectal Neoplasms
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Colorectal Neoplasms
Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy.
Colorectal Neoplasms
Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: A systematic review and meta-analysis.
Colorectal Neoplasms
Early Detection of Colorectal Cancer: a Multi-Center Pre-Clinical Case Cohort Study for Validation of a Combined DNA Stool Test.
Colorectal Neoplasms
Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer.
Colorectal Neoplasms
Effects of PKM2 Gene Silencing on the Proliferation and Apoptosis of Colorectal Cancer LS-147T and SW620 Cells.
Colorectal Neoplasms
Effects of shRNA-Mediated Silencing of PKM2 Gene on Aerobic Glycolysis, Cell Migration, Cell Invasion, and Apoptosis in Colorectal Cancer Cells.
Colorectal Neoplasms
Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer.
Colorectal Neoplasms
Evaluation of Fecal M2PK as a Diagnostic Marker in Colorectal Cancer.
Colorectal Neoplasms
Evaluation of the Performance of a Fecal Tumor M2-PK Rapid Kit Using Stool Specimens for Detection of Colorectal Tumors.
Colorectal Neoplasms
Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value.
Colorectal Neoplasms
Expression of tumor pyruvate kinase M2 isoform in plasma and stool of patients with colorectal cancer or adenomatous polyps.
Colorectal Neoplasms
Faecal biomarkers do not always identify pre-cancerous lesions in patients who present in primary care with bowel symptoms.
Colorectal Neoplasms
Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention.
Colorectal Neoplasms
Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening: A meta-analysis.
Colorectal Neoplasms
Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer.
Colorectal Neoplasms
Fecal M2-pyruvate kinase (M2-PK): A novel marker of intestinal inflammation.
Colorectal Neoplasms
Fecal tumor M2 pyruvate kinase is not a specific biomarker for colorectal cancer screening.
Colorectal Neoplasms
Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.
Colorectal Neoplasms
Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.
Colorectal Neoplasms
New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
Colorectal Neoplasms
p,p'-Dichlorodiphenyltrichloroethane promotes aerobic glycolysis via reactive oxygen species-mediated extracellular signal-regulated kinase/M2 isoform of pyruvate kinase (PKM2) signaling in colorectal cancer cells.
Colorectal Neoplasms
Plasma Tumor M2-Pyruvate Kinase Levels in Different Cancer Types.
Colorectal Neoplasms
Power of screening tests for colorectal cancer enhanced by high levels of M2-PK in addition to FOBT.
Colorectal Neoplasms
Prognostic value of plasmatic tumor M2 pyruvate kinase and carcinoembryonic antigen in the survival of colorectal cancer patients.
Colorectal Neoplasms
Prospective multicenter evaluation of fecal tumor pyruvate kinase type M2 (M2-PK) as a screening biomarker for colorectal neoplasia.
Colorectal Neoplasms
Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer.
Colorectal Neoplasms
Pyruvate kinase M2 and its evolving role as a prognostic marker in systemic malignancies besides colorectal carcinomas.
Colorectal Neoplasms
Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells.
Colorectal Neoplasms
Reply: New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
Colorectal Neoplasms
Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study.
Colorectal Neoplasms
Serum M2-pyruvate kinase: A promising non-invasive biomarker for colorectal cancer mass screening.
Colorectal Neoplasms
Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment.
Colorectal Neoplasms
Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation.
Colorectal Neoplasms
The Diagnostic Accuracy of the M2 Pyruvate Kinase Quick Stool Test--A Rapid Office Based Assay Test for the Detection of Colorectal Cancer.
Colorectal Neoplasms
The use of M2-pyruvate kinase as a stool biomarker for detection of colorectal cancer in tertiary teaching hospital: A comparative study.
Colorectal Neoplasms
The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test.
Colorectal Neoplasms
The value of fecal tumor M2 pyruvate kinase as a diagnostic tool for colorectal cancer screening.
Colorectal Neoplasms
Tumor M2 pyruvate kinase as a stool marker for colorectal cancer: stability at room temperature and implications for application in the screening setting.
Colorectal Neoplasms
Tumor M2 pyruvate kinase: a tumor marker and its clinical application in gastrointestinal malignancy.
Colorectal Neoplasms
Tumor M2-pyruvate kinase in stool as a biomarker for diagnosis of colorectal cancer: A meta-analysis.
Colorectal Neoplasms
Tumor M2-pyruvate kinase: a promising tumor marker in the diagnosis of gastro-intestinal cancer.
Colorectal Neoplasms
Tumor pyruvate kinase isoenzyme type M2 and immunochemical fecal occult blood test: performance in screening for colorectal cancer.
Colorectal Neoplasms
Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls.
Colorectal Neoplasms
Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients.
Colorectal Neoplasms
Tumour M2-pyruvate kinase: a gastrointestinal cancer marker.
Colorectal Neoplasms
[Clinical significance of blood and fecal tumor M2-pyruvate kinase expression in patients with colorectal cancer].
Colorectal Neoplasms
[Pilot study on M2-PK-- a new non-invasive parameter for early diagnosis of colorectal carcinoma]
Colorectal Neoplasms
[Pyruvate kinase M2 (tumor M2-PK) as a screening tool for colorectal cancer (CRC). A review of current published data]
Colorectal Neoplasms
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Coma
Effect of total hepatectomy on selected cerebral substrates and enzymes of the glycolytic pathways and Krebs cycle.
Communicable Diseases
How I do in front of an hemolytic anemia of unknown etiology?
Communicable Diseases
Increased erythrocytic osmotic fragility in anemic domestic shorthair and purebred cats.
Communicable Diseases
Listeria monocytogenes impairs enzymes of the phosphotransfer network and alters antioxidant/oxidant status in cattle brain structures.
Congenital Abnormalities
Significance of the electrophoretic modifications of defective pyruvate kinase variants. Study of six new observations.
Coronary Artery Disease
Role of pyruvate kinase M2 in oxidized LDL-induced macrophage foam cell formation and inflammation.
Coronary Artery Disease
Tissue MicroArray (TMA) analysis of normal and persistent Chlamydophila pneumoniae infection.
Crohn Disease
Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity.
Crohn Disease
Fecal M2-PK in Children with Crohn's Disease: A Preliminary Report.
Crohn Disease
Fecal M2-pyruvate kinase (M2-PK): A novel marker of intestinal inflammation.
Crohn Disease
P274. Diagnostic accuracy of fecal calprotectin and M2-pyruvate kinase in the prediction of endoscopic activity Crohn's disease.
Crohn Disease
Pyruvate Kinase M2 Regulates Apoptosis of Intestinal Epithelial Cells in Crohn's Disease.
Cryptococcosis
Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.
Cystic Fibrosis
Age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis and healthy children 0 to 10years old.
Cystic Fibrosis
Elevated faecal M2-pyruvate kinase in children with cystic fibrosis: A clue to the increased risk of intestinal malignancy in adulthood?
Cystic Fibrosis
Increased activity of four glycolytic enzymes in cultured fibroblasts from cystic fibrosis patients.
Cystinosis
Cysteamine prevents inhibition of thiol-containing enzymes caused by cystine or cystine dimethylester loading in rat brain cortex.
Cysts
Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii.
Cysts
Effect of antihydatid drugs on carbohydrate metabolism of metacestode of echinococcus granulosus.
Cysts
Effects of mebendazole, albendazole, and praziquantel on fumarate hydratase, pyruvate kinase, and phosphoenolpyruvate carboxykinase of Echinococcus granulosus cyst wall harbored in mice.
Cysts
Some glucose metabolic enzymes in various fractions of sarcocysts of Sarcocystis fusiformis of buffalo (Bubalus bubalis).
cytochrome-b5 reductase deficiency
Red cell enzymes.
Dehydration
Crystal structure of enolase indicates that enolase and pyruvate kinase evolved from a common ancestor.
Dehydration
Increased transcript levels and kinetic function of pyruvate kinase during severe dehydration in aestivating African clawed frogs, Xenopus laevis.
Dehydration
Preservative Effect of Polyols on the Stability of Biocatalysts during Short-term Dehydration Stress
Dehydration
Sucrose phosphate synthase activity and the co-ordination of carbon partitioning during sucrose and amino acid accumulation in desiccation-tolerant leaf material of the C4 resurrection plant Sporobolus stapfianus during dehydration.
Dengue
Phosphoproteomic analysis of dengue virus infected U937 cells and identification of pyruvate kinase M2 as a differentially phosphorylated phosphoprotein.
Dental Plaque
Relationship between Pyruvate Kinase Activity and Cariogenic Biofilm Formation in Streptococcus mutans Biotypes in Caries Patients.
Dermatitis, Atopic
[Activity of pyruvate kinase and glucose-6-phosphate dehydrogenase in polymorphonuclear granulocytes of patients with atopic dermatitis in the active stage and in remission]
Dermatofibrosarcoma
[Enzyme patterns in connective tissue proliferations (author's transl)]
Dermatomyositis
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Diabetes Mellitus, Experimental
[Effect of insulin and hydrocortisone on the isoenzyme composition of pyruvate kinase in the rabbit kidney]
Diabetes Mellitus, Experimental
[Pyruvate kinase from kidney medulla of rabbits in insulin deficiency]
Diabetes Mellitus, Type 1
Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy.
Diabetes Mellitus, Type 2
Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians.
Diabetes Mellitus, Type 2
Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy.
Diabetic Nephropathies
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.
Diabetic Nephropathies
Gene Regulatory Effect of Pyruvate Kinase M2 is Involved in Renal Inflammation in Type 2 Diabetic Nephropathy.
Diabetic Nephropathies
Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney.
Diabetic Nephropathies
Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy.
Diabetic Nephropathies
PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1? Secretion.
Diabetic Nephropathies
Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy.
Diabetic Retinopathy
Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy.
Diphtheria
Assignment of hexosaminidase-B to chromosome 5, its segregation after diphtheria toxin selection, and the linkage of hexosaminidase-A, mannose phosphate isomerase, and pyruvate kinase (M2).
Disseminated Intravascular Coagulation
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
Disseminated Intravascular Coagulation
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Down Syndrome
Blood cell pyruvate kinase activity in translocation Down's syndrome.
Duodenal Neoplasms
Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia.
Dupuytren Contracture
A comparative study of the activity of lysosomal and main metabolic pathway enzymes in tissue biopsies and cultured fibroblasts from Dupuytren's disease and palmar fascia. On the pathobiochemistry of connective tissue proliferation, I.
Dwarfism
Downregulation of OsPK1, a cytosolic pyruvate kinase, by T-DNA insertion causes dwarfism and panicle enclosure in rice.
Elliptocytosis, Hereditary
Rapid flow cytometric test using eosin-5-maleimide for diagnosis of red blood cell membrane disorders.
Elliptocytosis, Hereditary
[Hereditary elliptocytosis and pyruvate kinase deficiency of the erythrocytes]
Encephalomalacia
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
Endometrial Hyperplasia
Using Pyruvate Kinase as a Predictor for Patient With Endometrial Cancer Having Complex Hyperplasia With Atypia to Prevent Hysterectomy and Preserve Fertility: Retrospective Immunohistochemical Study.
Endometrial Neoplasms
Absolute quantification of potential cancer markers in clinical tissue homogenates using multiple reaction monitoring on a hybrid triple quadrupole/linear ion trap tandem mass spectrometer.
Endometrial Neoplasms
Enzymes of glucose metabolism in carcinoma of the cervix and endometrium of the human uterus.
Endometrial Neoplasms
Multiple reaction monitoring of mTRAQ-labeled peptides enables absolute quantification of endogenous levels of a potential cancer marker in cancerous and normal endometrial tissues.
Endometrial Neoplasms
Pyruvate Kinase M2 Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer That Is Associated with Poor Outcomes in Endometrial Carcinoma.
Endometrial Neoplasms
The effects of PGC-1? on the proliferation and energy metabolism of malignant endometrial cancer cells.
Endometrial Neoplasms
Using Pyruvate Kinase as a Predictor for Patient With Endometrial Cancer Having Complex Hyperplasia With Atypia to Prevent Hysterectomy and Preserve Fertility: Retrospective Immunohistochemical Study.
Equine Infectious Anemia
Equine infectious anemia. Pyruvate kinase deficiency in the red cells of thoroughbred horses.
Esophageal Neoplasms
Dihydroartemisinin represses esophageal cancer glycolysis by down-regulating pyruvate kinase M2.
Esophageal Neoplasms
Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms
Esophageal Neoplasms
Improved sensitivity in the diagnosis of gastro-intestinal tumors by fuzzy logic-based tumor marker profiles including the tumor M2-PK.
Esophageal Neoplasms
The influence of photodynamic therapy on the Warburg effect in esophageal cancer cells.
Esophageal Squamous Cell Carcinoma
M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh's ESCC and promotes proliferation and migration of ESCC cells.
Esophageal Squamous Cell Carcinoma
Plasma?derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.
Esophageal Squamous Cell Carcinoma
Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway.
Esophageal Squamous Cell Carcinoma
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
Esophageal Squamous Cell Carcinoma
The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma.
Familial Primary Pulmonary Hypertension
Idiopathic pulmonary arterial hypertension in a patient with pyruvate kinase deficiency and paravertebral extramedullary hematopoiesis.
Fanconi Anemia
Superoxide dismutase and other biochemical disorders in a family with Fanconi's anemia.
Fatty Liver
Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1? Transactivation in Steatohepatitis.
Fatty Liver
Fatty acids modulate the expression of pyruvate kinase and arachidonate-lipoxygenase through PPAR?/CYP2C45 pathway: a link to goose fatty liver.
Fatty Liver
Liver Pyruvate Kinase Promotes NAFLD/NASH in both Mice and Humans in a Sex-Specific Manner.
Fatty Liver
Non-alcoholic Fatty Liver Disease and Gastric Bypass Surgery Regulate Serum And Hepatic Levels of Pyruvate Kinase Isoenzyme M2.
Fatty Liver
PPAR? contributes to PKM2 and HK2 expression in fatty liver.
Fatty Liver
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Fetal Growth Retardation
Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies.
Fetal Growth Retardation
Pyruvate kinase deficiency complicating pregnancy.
Fetal Nutrition Disorders
Kinetic properties of pyruvate kinase in human maternal leukocytes in fetal malnutrition.
Fibroadenoma
Isozyme patterns of normal, benign, and malignant human breast tissues.
Fibrocystic Breast Disease
Comparison of glycolytic enzyme and isoenzyme activity in breast cancers and dysplasia.
Fibroma
[Enzyme patterns in connective tissue proliferations (author's transl)]
Gallstones
Concomitant laparoscopic splenectomy and cholecystectomy as an effective and minimally invasive treatment of pyruvate kinase deficiency with gallstones.
Gallstones
Gallstone Frequency in Children With Celiac Disease.
Gallstones
Red Blood Cell Enzyme Disorders.
Gastroenteritis
Fecal pyruvate kinase is not suitable for discrimination between inflammatory bowel disease exacerbation and acute gastroenteritis.
Gastrointestinal Diseases
Age-related faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers.
Gastrointestinal Diseases
The tumor marker tumor M2-PK: an application in the diagnosis of gastrointestinal cancer.
Gastrointestinal Neoplasms
A comparison of tumour M2-PK with carcinoembryonic antigen and CA19-9 in patients undergoing liver resection for colorectal metastases.
Gastrointestinal Neoplasms
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Gastrointestinal Neoplasms
The tumor marker tumor M2-PK: an application in the diagnosis of gastrointestinal cancer.
Gastrointestinal Neoplasms
Tumor M2-pyruvate kinase: a promising tumor marker in the diagnosis of gastro-intestinal cancer.
Gastrointestinal Neoplasms
Tumor pyruvate kinase M2: A promising molecular target of gastrointestinal cancer.
Gastrointestinal Neoplasms
Tumour M2-pyruvate kinase: a gastrointestinal cancer marker.
Gastrointestinal Neoplasms
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Gaucher Disease
Linkage disequilibrium of common Gaucher disease mutations with a polymorphic site in the pyruvate kinase (PKLR) gene.
Gaucher Disease
Linkage to Gaucher mutations in the Ashkenazi population: effect of drift on decay of linkage disequilibrium and evidence for heterozygote selection.
Gaucher Disease
Tight linkage of pyruvate kinase (PKLR) and glucocerebrosidase (GBA) genes.
Genetic Diseases, Inborn
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Genetic Diseases, Inborn
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
Genetic Diseases, Inborn
In Vitro and In Vivo Genetic Disease Modeling via NHEJ-Precise Deletions Using CRISPR-Cas9.
Genetic Diseases, Inborn
Novel mutations associated with pyruvate kinase deficiency in Brazil.
Genetic Diseases, Inborn
Prenatal diagnosis for a novel homozygous mutation in PKLR gene in an Indian family.
Glioblastoma
A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2 Induced Glycolytic Reprogramming in Glioblastoma.
Glioblastoma
A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme.
Glioblastoma
Assessment of epidermal growth factor receptor status in glioblastomas.
Glioblastoma
Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis.
Glioblastoma
Epigenetic silencing of miR-338 facilitates glioblastoma progression by de-repressing the pyruvate kinase M2-?-catenin axis.
Glioblastoma
Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo.
Glioblastoma
Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides.
Glioblastoma
PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.
Glioblastoma
Pyruvate kinase isozymes in neurons, glia, neuroblastoma, and glioblastoma.
Glioblastoma
Similar pyruvate kinase modifications in glioblastoma cells by 7?-hydroxycholesterol and glutamine withdrawal.
Glioblastoma
Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression.
Glioma
Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?
Glioma
Comparative Proteomic Analysis of Tumor Mesenchymal-Like Stem Cells Derived from High Grade versus Low Grade Gliomas.
Glioma
Control of glioma cell death and differentiation by PKM2-Oct4 interaction.
Glioma
Discrimination between neuronal and glial cell tumours by pyruvate kinase electrophoresis.
Glioma
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Glioma
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production.
Glioma
Isozymes of pyruvate kinase from human brain, meningiomas, and malignant gliomas.
Glioma
Metabolic state of glioma stem cells and nontumorigenic cells.
Glioma
Paclitaxel inhibits the migration of CD133+ U251 malignant glioma cells by reducing the expression of glycolytic enzymes.
Glioma
Phosphorylation of pyruvate kinase and glycolytic metabolism in three human glioma cell lines.
Glioma
Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
Glioma
Pyruvate kinase in human brain tumours. Its significance in the treatment of gliomas.
Glioma
Pyruvate kinase inhibition in the diagnosis of gliomas with an intermediate degree of malignancy.
Glioma
Pyruvate kinase m2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.
Glioma
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells.
Glioma
Severe H1N1-associated acute respiratory failure in immunocompromised children.
Glioma
The pyruvate kinase isoenzyme shift in human gliomas: a potential marker in the treatment of gliomas.
Glioma
The Role of Pyruvate Kinase M2 in Cancer Metabolism.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
A combined system for the study of glutathione metabolism in erythrocytes.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Erythrocyte glucose-6-phosphate dehydrogenase and pyruvate kinase activities in hemoglobin H disease.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Extramedullary blast crisis and hemolytic anemia in a patient with t(3p+;4q-) and rapidly evolving myelogenous leukemia.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Frequency of glutathione reductase, pyruvate kinase and glucose-6-phosphate dehydrogenase deficiency in a Spanish population.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
G6PD/PK ratio: a reliable parameter to identify glucose-6-phosphate dehydrogenase deficiency associated with microcytic anemia in heterozygous subjects.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Genetic control of resistance to human malaria.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Heterozygous pyruvate kinase deficiency and severe hemolytic anemia in a pregnant woman with concomitant, glucose-6-phosphate dehydrogenase deficiency.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Pyruvate kinase deficiency. Association with G6PD deficiency.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Screening of pyruvate kinase deficiency and G6PD deficiency in Chinese newborn in Hong Kong.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Unexplained extreme hyperbilirubinemia among neonates in a multihospital healthcare system.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
[Double erythrocyte enzymopathy. Acquired pyruvate kinase and inherited glucose-6-phosphate dehydrogenase deficiencies]
glucose-6-phosphate dehydrogenase (nadp+) deficiency
[Glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency]
glucose-6-phosphate dehydrogenase (nadp+) deficiency
[The importance of determination of ferritin levels in erythrocytes]
glucose-6-phosphate dehydrogenase (nadp+) deficiency
[Use of nuclear magnetic resonance in the study of hemolytic anemia. Preliminary report]
glucose-6-phosphate isomerase deficiency
A combined system for the study of glutathione metabolism in erythrocytes.
glucose-6-phosphate isomerase deficiency
Red blood cell disorders in Rwandese neonates: screening for sickle cell disease and glucose-6-phosphate dehydrogenase deficiency.
glucose-6-phosphate isomerase deficiency
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Glucosephosphate Dehydrogenase Deficiency
A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.
Glucosephosphate Dehydrogenase Deficiency
Erythrocyte glucose-6-phosphate dehydrogenase and pyruvate kinase activities in hemoglobin H disease.
Glucosephosphate Dehydrogenase Deficiency
Extramedullary blast crisis and hemolytic anemia in a patient with t(3p+;4q-) and rapidly evolving myelogenous leukemia.
Glucosephosphate Dehydrogenase Deficiency
Frequency of glutathione reductase, pyruvate kinase and glucose-6-phosphate dehydrogenase deficiency in a Spanish population.
Glucosephosphate Dehydrogenase Deficiency
G6PD/PK ratio: a reliable parameter to identify glucose-6-phosphate dehydrogenase deficiency associated with microcytic anemia in heterozygous subjects.
Glucosephosphate Dehydrogenase Deficiency
Genetic control of resistance to human malaria.
Glucosephosphate Dehydrogenase Deficiency
Heterozygous pyruvate kinase deficiency and severe hemolytic anemia in a pregnant woman with concomitant, glucose-6-phosphate dehydrogenase deficiency.
Glucosephosphate Dehydrogenase Deficiency
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Glucosephosphate Dehydrogenase Deficiency
Pyruvate kinase deficiency. Association with G6PD deficiency.
Glucosephosphate Dehydrogenase Deficiency
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Glucosephosphate Dehydrogenase Deficiency
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
Glucosephosphate Dehydrogenase Deficiency
Screening of pyruvate kinase deficiency and G6PD deficiency in Chinese newborn in Hong Kong.
Glucosephosphate Dehydrogenase Deficiency
Spectrum and hematological profile of hereditary anemia in North Indians: SGPGI experience.
Glucosephosphate Dehydrogenase Deficiency
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
Glucosephosphate Dehydrogenase Deficiency
Unexplained extreme hyperbilirubinemia among neonates in a multihospital healthcare system.
Glucosephosphate Dehydrogenase Deficiency
[Double erythrocyte enzymopathy. Acquired pyruvate kinase and inherited glucose-6-phosphate dehydrogenase deficiencies]
Glucosephosphate Dehydrogenase Deficiency
[Glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency]
Glucosephosphate Dehydrogenase Deficiency
[The importance of determination of ferritin levels in erythrocytes]
glutamate-cysteine ligase deficiency
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
glutathione-disulfide reductase deficiency
A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.
glutathione-disulfide reductase deficiency
Hematologic and biochemical observations in Gazella dama, G. dorcas and G. cuvieri.
Glycogen Storage Disease
Muscle pyruvate kinase deficiency: glycogen storage disease or mitochondrial myopathy?
Glycosuria
Neonatal islet cell transplantation in the diabetic rat: effect on hepatic enzyme activity and glucose homeostasis.
Heart Failure
Inhibiting the Pkm2/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI.
Heart Failure
Plasma concentrations of tumour dimeric pyruvate kinase are increased in patients with chronic cardiac failure.
Heart Failure
Puerarin inhibits apoptosis and inflammation in myocardial cells via PPAR? expression in rats with chronic heart failure.
Heart Failure
[Hemochromatosis and puryvate kinase deficiency (author's transl)]
Hematologic Diseases
A novel PKLR gene mutation identified using advanced molecular techniques.
Hematologic Diseases
Heterogeneity of erythrocyte pyruvate kinase deficiency and related metabolic disorders in patients with hematological diseases.
Hematologic Diseases
Plasma levels of tumor M2-pyruvate kinase should not be used as a tumor marker for hematological malignancies and solid tumors.
Hematologic Neoplasms
Plasma levels of tumor M2-pyruvate kinase should not be used as a tumor marker for hematological malignancies and solid tumors.
Hemochromatosis
A rare combination of two inherited disorders in one patient: pyruvate kinase deficiency and hemochromatosis.
Hemochromatosis
An autopsy case of pyruvate kinase deficiency anemia associated with severe hemochromatosis.
Hemochromatosis
Erythrocytic Pyruvate Kinase Mutations Causing Hemolytic Anemia, Osteosclerosis, and Secondary Hemochromatosis in Dogs.
Hemochromatosis
Hemochromatosis and pyruvate kinase deficiency. Report of a case and review of the literature.
Hemochromatosis
Iron status and HFE genotype in erythrocyte pyruvate kinase deficiency: study of Italian cases.
Hemochromatosis
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Hemochromatosis
Pyruvate kinase deficiency causing hemolytic anemia with secondary hemochromatosis in a Cairn terrier.
Hemochromatosis
[Hemochromatosis and puryvate kinase deficiency (author's transl)]
Hemoglobin C Disease
[Chronic non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency in a Costa Rican family carrying hemoglobin C disease]
Hemoglobinopathies
Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE).
Hemoglobinopathies
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Hepatitis B
Aerobic glycolysis supports hepatitis B virus protein synthesis through interaction between viral surface antigen and pyruvate kinase isoform M2.
Hepatitis C
Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B.
Hereditary Sensory and Autonomic Neuropathies
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
hexokinase deficiency
Frequency of glucose-6-phosphate dehydrogenase, pyruvate kinase and hexokinase deficiency in the Saudi population.
hexokinase deficiency
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Hydrops Fetalis
Fetal anaemia due to pyruvate kinase deficiency.
Hydrops Fetalis
Hydrops fetalis associated with erythrocyte pyruvate kinase deficiency.
Hydrops Fetalis
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
Hyperandrogenism
A nontargeted study of muscle proteome in severely obese women with androgen excess compared with severely obese men and nonhyperandrogenic women.
Hyperbilirubinemia, Neonatal
Neonatal hyperbilirubinemia caused by pyruvate kinase deficiency.
Hyperbilirubinemia, Neonatal
[The clinical and laboratory characteristics of congenital pyruvate kinase deficiency].
Hyperglycemia
From Langerhans islets to pancreas transplantation over the past 30 years: a review with personal contributions.
Hyperglycemia
Identification of allosteric-activating drug leads for human liver pyruvate kinase.
Hyperglycemia
Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets.
Hyperhomocysteinemia
Homocysteine induces energy imbalance in rat skeletal muscle: Is creatine a protector?
Hyperhomocysteinemia
T-cell-derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2.
Hyperinsulinism
Derangement in hepatic enzymes caused by sucrose-drinking and its implication for the development of hyperglycemia in female Wistar fatty rats.
Hyperinsulinism
Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis.
Hyperinsulinism
Insulin resistance in the obese hyperglycemic (ob/ob) mouse. Failure of hyperinsulinemia to activate hepatic pyruvate kinase (PK).
Hyperinsulinism
Possible metabolic implications of pyruvate and lactate accumulation in the liver of pregnant rats.
Hyperlipidemias
[The effect of oral synthetic protease inhibitor (FOY 305) on endocrine pancreas and carbohydrate and lipid metabolism in normal and streptozotocin-induced diabetic rats]
Hypersensitivity
DNase-I hypersensitivity analysis of the L-type pyruvate kinase gene in rats and transgenic mice.
Hypersensitivity
Identification of pyruvate kinase as a novel allergen in whiteleg shrimp (Litopenaeus vannamei) by specific-IgE present in patients with shrimp allergy.
Hypertension
Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
Hypertension
Idiopathic pulmonary arterial hypertension in a patient with pyruvate kinase deficiency and paravertebral extramedullary hematopoiesis.
Hypertension
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Hypertension
Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.
Hypertension, Pulmonary
Recurrent thromboembolic disease following splenectomy for pyruvate kinase deficiency.
Hyperthyroidism
13C NMR study of gluconeogenesis from labeled alanine in hepatocytes from euthyroid and hyperthyroid rats.
Hyperthyroidism
Effect of thyroid hormones on the glycolytic enzyme activity in brain areas of the rat.
Hyperthyroidism
Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat.
Hyperthyroidism
Hepatic carbon flux after re-feeding. Hyperthyroidism blocks glycogen synthesis and the suppression of glucose output observed in response to carbohydrate re-feeding.
Hyperthyroidism
[Intraerythrocytic enzyme activities in euthyroid subjects and hyperthyroid patients before treatment and following stabilization of metabolism using radioiodine therapy]
Hypertriglyceridemia
Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency.
Hypertrophy, Right Ventricular
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Hypervitaminosis A
Early effects of vitamin A toxicity on hepatic glycolysis in rat.
Hypoglycemia
Carbohydrate metabolism in temporal and persistent hypoglycemic chickens induced by insulin infusion.
Hypogonadism
Decrease of aldolase and pyruvate kinase activity in erythrocytes of individuals with male hypogonadism as an expression of lack of androgen influence on the bone marrow.
Hypohidrosis
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
Hypothyroidism
Hormonal control of glucose production and pyruvate kinase activity in isolated rat liver cells: influence of hypothyroidism.
Hypothyroidism
[Effect of thyroid hormones on the activity of pyruvate kinase and lactate dehydrogenase in mature rat brain]
Hypoxia, Brain
[Effect of hypoxia on carbohydrate metabolism in scorpion tissues]
Hypoxia-Ischemia, Brain
PKM2 Aggravates Cerebral Ischemia Reperfusion-Induced Neuroinflammation via TLR4/MyD88/TRAF6 Signaling Pathway.
Infant Nutrition Disorders
[Erythrocyte enzyme activity (glucose-6-phosphate dehydrogenase, pyruvate kinase, catalase) in 13 cases of protein-calorie malnutrition in infants]
Infections
Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Infections
Changes in the contents of metabolites and enzyme activities in rice plants responding to Rhizoctonia solani Kuhn infection: activation of glycolysis and connection to phenylpropanoid pathway.
Infections
Comparison of gene expression of pyruvate kinase and tryparedoxin peroxidase in metacyclic promastigote forms of Leishmania (L.) tropica and L. major by real-time PCR
Infections
Detection of candidal antigens in autoimmune polyglandular syndrome type I.
Infections
Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections.
Infections
Estimating the degree of infection of Plasmodium berghei infected red blood cells by evaluation of pyruvate kinase activity.
Infections
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria.
Infections
Flexible Metabolism and Suppression of Latent Enzymes Are Important for Escherichia coli Adaptation to Diverse Environments within the Host.
Infections
Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum.
Infections
Host and Bacterial Glycolysis During Chlamydia trachomatis Infection.
Infections
Human metapneumovirus infection of airway epithelial cells is associated with changes in core metabolic pathways.
Infections
Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells.
Infections
Inhibition of the pentose phosphate shunt by 2,3-diphosphoglycerate in erythrocyte pyruvate kinase deficiency.
Infections
Intestinal injury caused by Eimeria spp. impairs the phosphotransfer network and gain weight in experimentally infected chicken chicks.
Infections
KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma.
Infections
Non-Metabolic Role of PKM2 in Regulation of the HIV-1 LTR.
Infections
Parasitic lung infections.
Infections
Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
Infections
Pseudomonas aeruginosa strain PA01 impairs enzymes of the phosphotransfer network in the gills of Rhamdia quelen.
Infections
Pyruvate kinase deficiency and malaria.
Infections
Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice.
Infections
Pyruvate kinase is necessary for Brucella abortus full virulence in BALB/c mouse.
Infections
Single gene effects in mouse models of host: pathogen interactions.
Infections
The pyruvate-tricarboxylic acid cycle node: a focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis.
Infections
[Glycolysis and pentose-phosphate pathway ratio in staphylococcus from the female genitalia in norm and dysbiosis]
Infectious Mononucleosis
Acquired hemolytic anemia associated with infectious mononucleosis in a patient with congenital pyruvate kinase deficiency.
Infectious Mononucleosis
[Pyruvate kinase deficiency, infectious mononucleosis, hemolytic anemia with cold autoantibodies and massive splenic infarction]
Infertility
Buccal micronucleus cytome biomarkers in Algerian couples with idiopathic infertility.
Infertility
Reprogramming homing endonuclease specificity through computational design and directed evolution.
Inflammatory Bowel Diseases
Comparison of a novel fecal marker--fecal tumor pyruvate kinase type M2 (M2-PK) with fecal calprotectin in patients with inflammatory bowel disease: a prospective study.
Inflammatory Bowel Diseases
Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity.
Inflammatory Bowel Diseases
Fecal pyruvate kinase is not suitable for discrimination between inflammatory bowel disease exacerbation and acute gastroenteritis.
Inflammatory Bowel Diseases
Fecal pyruvate kinase: A potential new marker for intestinal inflammation in children with inflammatory bowel disease.
Inflammatory Bowel Diseases
P245. Accuracy of fecal M2-Pyruvate Kinase compared with fecal calprotectin to assess endoscopic severity in patients with inflammatory bowel diseases.
Inflammatory Bowel Diseases
Tumor pyruvate kinase isoenzyme type M2 and immunochemical fecal occult blood test: performance in screening for colorectal cancer.
Inflammatory Bowel Diseases
[Pilot study on M2-PK-- a new non-invasive parameter for early diagnosis of colorectal carcinoma]
Inflammatory Bowel Diseases
[Pyruvate kinase M2 (tumor M2-PK) as a screening tool for colorectal cancer (CRC). A review of current published data]
Influenza, Human
Experimental validation of influenza A virus matrix protein (M1) interaction with host cellular alpha enolase and pyruvate kinase.
Influenza, Human
Influenza Virus Infection Induces Host Pyruvate Kinase M Which Interacts with Viral RNA-Dependent RNA Polymerase.
Insulin Resistance
Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats.
Insulin Resistance
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Insulin Resistance
Hypoglycemic effects and modulation of gut microbiota of diabetic mice by saponin from Polygonatum sibiricum.
Insulin Resistance
Insulin resistance in the obese hyperglycemic (ob/ob) mouse. Failure of hyperinsulinemia to activate hepatic pyruvate kinase (PK).
Insulin Resistance
Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM.
Insulin Resistance
Liver Pyruvate Kinase Promotes NAFLD/NASH in both Mice and Humans in a Sex-Specific Manner.
Insulinoma
cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4{alpha}, and CBP.
Insulinoma
cAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter.
Insulinoma
Expression of liver type pyruvate kinase in insulinoma cells: involvement of LF-B1 (HNF1).
Insulinoma
Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells.
Insulinoma
Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells.
Insulinoma
The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type.
Intestinal Neoplasms
[Intestinal cancer precautions. Stool test for tumor M2 pyruvate kinase]
Intracranial Embolism
Naftidrofuryl oxalate improves impaired brain glucose metabolism after microsphere-induced cerebral embolism in rats.
Iron Deficiencies
Fragility of abnormal erythrocytes evaluated by response to shear stress.
Iron Deficiencies
Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters.
Iron Deficiencies
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
Iron Deficiencies
[The importance of determination of ferritin levels in erythrocytes]
Iron Overload
Erythropoietin in the treatment of iron overload in a patient with hemolytic anemia and pyruvate kinase deficiency.
Iron Overload
Hemochromatosis and pyruvate kinase deficiency. Report of a case and review of the literature.
Iron Overload
Iron overload associated with congenital pyruvate kinase deficiency and high dose ascorbic acid ingestion.
Iron Overload
Iron overload in congenital erythrocyte pyruvate kinase deficiency.
Iron Overload
Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study.
Iron Overload
Pyruvate kinase deficiency in pregnancy complicated by iron overload.
Iron Overload
Red Blood Cell Enzyme Disorders.
Iron Overload
The dangers of iron overload in pyruvate kinase deficiency.
Iron Overload
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ?-thalassemia mouse model.
Iron Overload
Unexpectedly high but still asymptomatic iron overload in a patient with pyruvate kinase deficiency.
Iron Overload
[Iron overload in congenital hemolytic anemia caused by pyruvate kinase deficiency. A major late complication]
Ischemic Stroke
Correction to: Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities after Ischemic Stroke in Adult Mice.
Ischemic Stroke
Ischaemic stroke complicating pyruvate kinase deficiency.
Ischemic Stroke
PKM2 promotes neutrophil activation and cerebral thrombo-inflammation: Therapeutic implications for ischemic stroke.
Ischemic Stroke
Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice.
Jaundice, Neonatal
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
Jaundice, Neonatal
Glucose-6-phosphate dehydrogenase and red cell pyruvate kinase deficiency in neonatal jaundice cases in egypt.
Jaundice, Neonatal
Red Blood Cell Enzyme Disorders.
Jaundice, Neonatal
Red cell pyruvate kinase deficiency in neonatal jaundice cases in India.
Jaundice, Neonatal
Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency.
Kidney Failure, Chronic
Effects of chronic renal failure on the regulation of pyruvate kinase.
Kidney Failure, Chronic
Energy production, intracellular amino acid pools, and protein synthesis in chronic renal disease.
Kidney Neoplasms
Identification of anti-tumoral feedback loop between VHL? and hnRNPA2B1 in renal cancer.
Kidney Neoplasms
Overexpressed miR-122-5p Promotes Cell Viability, Proliferation, Migration And Glycolysis Of Renal Cancer By Negatively Regulating PKM2.
Kidney Neoplasms
Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1,6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI/SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report.
Kidney Neoplasms
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Kidney Neoplasms
Tumoral Pyruvate Kinase L/R as a Predictive Marker for the Treatment of Renal Cancer Patients with Sunitinib and Sorafenib.
Klatskin Tumor
PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma.
Leg Ulcer
Pyruvate kinase deficiency and leg ulcers.
Leg Ulcer
[Haemolytic anaemia an leg ulcers due to pyruvate kinase deficiency. report of the second venezuelan family (author's transl)]
Leiomyoma
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Leiomyoma
Compensatory alterations in energy homeostasis characterized in uterine tumors from hereditary leiomyomatosis and renal cell cancer.
Leiomyosarcoma
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Leiomyosarcoma
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Lemierre Syndrome
Lemierre Syndrome in a Patient With Splenectomy Secondary to Pyruvate Kinase Deficiency, Complicated by Heparin Resistance.
Leprosy
Anti-sarcopenic effects of diamino-diphenyl sulfone observed in elderly female leprosy survivors: a cross-sectional study.
Leukemia
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Leukemia
Acquired red cell pyruvate kinase deficiency in acute leukemias.
Leukemia
Acquired red cell pyruvate kinase deficiency in leukemias and related disorders.
Leukemia
Apoptotic changes precede mitochondrial dysfunction in red cell-type pyruvate kinase mutant mouse erythroleukemia cell lines.
Leukemia
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Leukemia
Chronic myelomonocytic leukemia associated with hereditary pyruvate kinase deficiency and multiple acquired erythrocyte abnormalities.
Leukemia
Erythrocyte pyruvate kinase activity during chemotherapy in children with leukemia and lymphoma.
Leukemia
Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated Leukemia.
Leukemia
Isozyme patterns of pyruvate kinase and differentiation of Friend leukemia cells.
Leukemia
Mechanisms of the acquired erythrocyte enzyme deficiencies in blood diseases.
Leukemia
Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.
Leukemia
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells.
Leukemia
Red cell enzymopathies in leukemias.
Leukemia
Red cell pyruvate kinase in acute leukemia.
Leukemia
SUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells.
Leukemia
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase.
Leukemia
[A case of familial pyruvate kinase deficiency associated with acute myelomonocytic leukemia]
Leukemia
[Activity of pyruvate kinase in erythrocytes in acute leukemia in children]
Leukemia
[Construction of shRNA eukaryotic expression vectors of pkm2 gene and their effect on drug resistant cell line of acute promyelocytic leukemia]
Leukemia
[Erythrocyte metabolism in patients with acute leukemia and a deficiency of the enzyme pyruvate kinase]
Leukemia
[Relative deficiency of glutathione reductase and or pyruvate kinase in erythrocytes in aplastic anemia and acute leukemia]
Leukemia, Erythroblastic, Acute
Apoptotic changes precede mitochondrial dysfunction in red cell-type pyruvate kinase mutant mouse erythroleukemia cell lines.
Leukemia, Erythroblastic, Acute
Pattern of pyruvate kinase isozymes in erythroleukemia cell lines and in normal human erythroblasts.
Leukemia, Erythroblastic, Acute
Secondary red cell pyruvate kinase deficiency. II. Biochemical studies for the mechanism of pyruvate kinase deficiency in erythroleukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Acute myeloblastic leukemia following non-Hodgkin lymphoma in an adolescent. A report of a case with preleukemic syndrome, and review of the literature.
Leukemia, Lymphocytic, Chronic, B-Cell
Isozyme distribution of hexokinase, phosphofructokinase and pyruvate kinase in lymphocytes from patients with chronic lymphocytic leukemia.
Leukemia, Lymphoid
Further studies on migration and colonization of leukemic lymphoblasts in AKR and HSS inbred mice.
Leukemia, Myeloid
[A case of acute granulocytic leukemia with erythrocyte pyruvate kinase deficiency and bone marrow chromosome aberration (author's transl)]
Leukemia, Myeloid, Acute
Mechanisms of the acquired erythrocyte enzyme deficiencies in blood diseases.
Leukemia, Myeloid, Acute
Patient with pyruvate kinase deficiency developed acute myelogenous leukemia.
Leukemia, Myeloid, Acute
[The effect of cytostatic therapy on pyruvate kinase activity in the erythrocytes of patients with acute myelocytic leukemia]
Leukemia, Myelomonocytic, Acute
[A case of familial pyruvate kinase deficiency associated with acute myelomonocytic leukemia]
Leukemia, Myelomonocytic, Chronic
Chronic myelomonocytic leukemia associated with hereditary pyruvate kinase deficiency and multiple acquired erythrocyte abnormalities.
Leukemia, Promyelocytic, Acute
[Construction of shRNA eukaryotic expression vectors of pkm2 gene and their effect on drug resistant cell line of acute promyelocytic leukemia]
Liver Cirrhosis
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
Liver Cirrhosis
Changes of aldolase and pyruvate kinase isoenzymes during liver cirrhosis induction with carbon tetrachloride and 2-acetylamino-fluorene.
Liver Diseases
Non-alcoholic Fatty Liver Disease and Gastric Bypass Surgery Regulate Serum And Hepatic Levels of Pyruvate Kinase Isoenzyme M2.
Liver Diseases
Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn.
Liver Diseases
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Liver Failure
Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency.
Liver Failure
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Liver Failure
Successful Liver Transplants for Liver Failure Associated With Pyruvate Kinase Deficiency.
Liver Neoplasms
MicroRNA 675 cooperates PKM2 to aggravate progression of human liver cancer stem cells induced from embryonic stem cells.
Liver Neoplasms
Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1? and Bcl-xL in culture.
Liver Neoplasms, Experimental
Amino-acid composition of pyruvate kinase M2 isoenzyme variants from rat liver and Morris hepatoma 7777.
Liver Neoplasms, Experimental
Comparison of pyruvate kinase variants from rat liver and Morris hepatoma 7777, obtained by an affinity chromatography on blue sepharose CL-6B.
Liver Neoplasms, Experimental
Electrophoretic pattern of cytosolic pyruvate kinase fractions A and B (type L and M2) from normal rat liver and Morris hepatoma 7777.
Liver Neoplasms, Experimental
N-acetylneuraminic acid, phosphate and thiol groups of pyruvate kinase isoenzymes from Morris hepatoma 7777 and normal rat liver.
Liver Neoplasms, Experimental
Pyruvate kinase isoenzymes in chromatin extracts of Ehrlich ascites tumour, Morris hepatoma 7777 and normal mouse and rat livers.
Liver Neoplasms, Experimental
The dual activity of pyruvate kinase type M2 from chromatin extracts of neoplastic cells.
Lung Diseases
Quantitative detection of tumor M2-pyruvate kinase in plasma of patients with lung cancer in comparison to other lung diseases.
Lung Diseases
Serum tumour M2-pyruvate kinase as a biomarker for diagnosis and prognosis of early-stage non-small cell lung cancer.
Lung Neoplasms
A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia.
Lung Neoplasms
Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer.
Lung Neoplasms
Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells.
Lung Neoplasms
Aspirin-triggered resolvin D1 inhibits TGF-?1-induced EMT through the inhibition of the mTOR pathway by reducing the expression of PKM2 and is closely linked to oxidative stress.
Lung Neoplasms
Comparison of the tumor markers tumor M2-PK, CEA, CYFRA 21-1, NSE and SCC in the diagnosis of lung cancer.
Lung Neoplasms
Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association.
Lung Neoplasms
Down-regulation of miR-214 inhibits proliferation and glycolysis in non-small-cell lung cancer cells via down-regulating the expression of hexokinase 2 and pyruvate kinase isozyme M2.
Lung Neoplasms
Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model.
Lung Neoplasms
Fuzzy logic-based tumor marker profiles improved sensitivity of the detection of progression in small-cell lung cancer patients.
Lung Neoplasms
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Lung Neoplasms
Identification of a new pyruvate kinase M2 isoform (PKM2) activator for the treatment of non-small-cell lung cancer (NSCLC).
Lung Neoplasms
Identification of five candidate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines.
Lung Neoplasms
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Lung Neoplasms
Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors.
Lung Neoplasms
Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro.
Lung Neoplasms
Limited Clinical Significance of Dimeric Form of Pyruvate Kinase as a Diagnostic and Prognostic Biomarker in Non-small Cell Lung Cancer.
Lung Neoplasms
Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells.
Lung Neoplasms
Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2.
Lung Neoplasms
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1? and pyruvate kinase M2.
Lung Neoplasms
Quantitative detection of tumor M2-pyruvate kinase in plasma of patients with lung cancer in comparison to other lung diseases.
Lung Neoplasms
RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells.
Lung Neoplasms
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.
Lung Neoplasms
Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway.
Lung Neoplasms
Serum tumour M2-pyruvate kinase as a biomarker for diagnosis and prognosis of early-stage non-small cell lung cancer.
Lung Neoplasms
Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells.
Lung Neoplasms
Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo.
Lung Neoplasms
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
Lung Neoplasms
Tumor M2 pyruvate kinase in diagnosis of nonsmall cell lung cancer: A meta-analysis based on Chinese population.
Lung Neoplasms
Tumor M2-pyruvate kinase in lung cancer patients: immunohistochemical detection and disease monitoring.
Lung Neoplasms
Tumor M2-pyruvate kinase in the follow-up of inoperable lung cancer patients: a pilot study.
Lung Neoplasms
Tumor markers in detection of lung cancer.
Lung Neoplasms
Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection.
Lung Neoplasms
[The role of oncomarkers CEA, Cyfra-21, NSE, TU M2-PK in diagnosis and treatment of lung cancer]
Lung Neoplasms
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
Lung Neoplasms
[Tripartite-motif protein 25 and pyruvate kinase M2 protein expression in non-small cell lung cancer].
Lupus Erythematosus, Systemic
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Lymphadenopathy
Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
Lymphatic Metastasis
Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats.
Lymphatic Metastasis
Relationship between 18-F-fluoro-deoxy-D-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma.
Lymphatic Metastasis
The Value of Expression of M2-PK and VEGF in Patients with Advanced Gastric Cancer.
Lymphoma
Changes in activities of enzymes related to energy metabolism in canine lymphoma cells.
Lymphoma
Erythrocyte pyruvate kinase activity during chemotherapy in children with leukemia and lymphoma.
Lymphoma
Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.
Lymphoma
Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism.
Lymphoma
Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells.
Lymphoma
Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma.
Lymphoma
Pyruvate Kinase M2 Knockdown Suppresses Migration, Invasion, and Epithelial-Mesenchymal Transition of Gastric Carcinoma via Hypoxia-Inducible Factor Alpha/B-Cell Lymphoma 6 Pathway.
Lymphoma
The double dealing of cyclin D1.
Lymphoma, B-Cell
Characteristics of red cell pyruvate kinase (PK) and pyrimidine 5'nucleotidase (P5N) abnormalities in acute leukaemia and chronic lymphoid diseases with leukaemic expression.
Lymphoma, B-Cell
HIF-?/PKM2 and PI3K-AKT pathways involved in the protection by dexmedetomidine against isoflurane or bupivacaine-induced apoptosis in hippocampal neuronal HT22 cells.
Lymphoma, Large-Cell, Anaplastic
Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma.
Lymphoma, Mantle-Cell
The double dealing of cyclin D1.
Lymphoma, Non-Hodgkin
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Lymphoma, Non-Hodgkin
Erythrocyte pyruvate kinase activity in patients with haematological malignancies.
Lymphoproliferative Disorders
Plasma TM2-PK levels in mycosis fungoides patients.
Malaria
Babesia rodhaini: the protective effect of pyruvate kinase deficiency in mice.
Malaria
Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.
Malaria
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria.
Malaria
Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum.
Malaria
Genetic control of resistance to human malaria.
Malaria
Genetic diversity in human erythrocyte pyruvate kinase.
Malaria
Human red blood cell polymorphisms and malaria.
Malaria
Malaria: looking for selection signatures in the human PKLR gene region.
Malaria
Mapping of Char10, a novel malaria susceptibility locus on mouse chromosome 9.
Malaria
Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population.
Malaria
Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model.
Malaria
Pyruvate Kinase and Fc? Receptor Gene Copy Numbers Associated With Malaria Phenotypes.
Malaria
Pyruvate kinase deficiency and malaria.
Malaria
Pyruvate kinase deficiency in mice protects against malaria.
Malaria
Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria.
Malaria
Pyruvate kinase deficiency protects against malaria in humans.
Malaria
Pyruvate kinase deficiency: correlation between enzyme activity, extent of hemolytic anemia and protection against malaria in independent mouse mutants.
Malaria
Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism.
Malaria
Pyruvate kinase in malaria host-parasite interaction.
Malaria
Red cell glucose-6-phosphate dehydrogenase status and pyruvate kinase activity in a Nigerian population.
Malaria
The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.
Malaria, Falciparum
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria.
Malnutrition
Effect of protein malnutrition on the glycolytic and glutaminolytic enzyme activity of rat thymus and mesenteric lymph nodes.
Mastocytoma
Independent regulation of pyruvate kinase expression by cyclic AMP and prostaglandin F2 alpha in mouse mastocytoma cells.
Mastocytoma
Pyruvate kinase and total protein are regulated differently during growth of P-815 mastocytoma cells.
Mastocytoma
Regulation of pyruvate kinase expression and growth in mastocytoma cells. I. Initial observations.
Mastocytoma
Regulation of pyruvate kinase expression and growth in P-815 mastocytoma cells. II. Potential role of prostaglandins.
Medulloblastoma
Discrimination between neuronal and glial cell tumours by pyruvate kinase electrophoresis.
Medulloblastoma
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Medulloblastoma
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Medulloblastoma
Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Melanoma
B16 melanoma secretomes and in vitro invasiveness: syntenin as an invasion modulator.
Melanoma
Metabolic characterization of three hamster melanoma variants.
Melanoma
Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.
Melanoma
Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.
Melanoma
Tumor type M2 pyruvate kinase (TuM2-PK) as a novel plasma tumor marker in melanoma.
Melanoma, Amelanotic
Metabolic characterization of three hamster melanoma variants.
Melanoma, Experimental
Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.
Meningioma
Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?
Meningioma
Interaction of M1 and M2 isozymes pyruvate kinase from human tissues with phospholipids.
Meningioma
Isozymes of pyruvate kinase from human brain, meningiomas, and malignant gliomas.
Meningioma
Purification and characterization of human meningioma M2-type pyruvate kinase.
Meningioma
Regulation of M2-type pyruvate kinase from human meningioma by allosteric effectors fructose 1,6 diphosphate and L-alanine.
Metabolic Diseases
Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA.
Metabolic Diseases
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Metabolic Diseases
Mathematical modelling of metabolic pathways affected by an enzyme deficiency. A mathematical model of glycolysis in normal and pyruvate-kinase-deficient red blood cells.
Metabolic Diseases
Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.
Metabolic Diseases
The effects of the interactions between amino acids on pyruvate kinase activity from the brain cortex of young rats.
Mouth Neoplasms
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer.
Mouth Neoplasms
The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells.
Multicystic Dysplastic Kidney
Dyserythropoiesis in a child with pyruvate kinase deficiency and coexistent unilateral multicystic dysplastic kidney.
Multiple Myeloma
Erythrocyte enzymes in myelomatosis.
Multiple Myeloma
NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase.
Multiple Myeloma
Pyruvate kinase isoform M2 (PKM2) participates in multiple myeloma cell proliferation, adhesion and chemoresistance.
Muscular Diseases
Decreased prostacyclin synthesis in vitamin E-deficient rabbit aorta.
Muscular Diseases
Effect of chronic alcoholism on human muscle glycogen and glucose metabolism.
Muscular Diseases
Functions of vitamin E in reproduction and in prostacyclin and immunoglobulin synthesis in rats.
Muscular Diseases
Is methyl-branching in alpha-tocopherol's "tail" important for its in vivo activity? Rat curative myopathy bioassay measurements of the vitamin E activity of three 2RS-n-alkyl-2,5,7,8-tetramethyl-6-hydroxychromans.
Muscular Diseases
Pinpointing oxidative stress behind the white striping myopathy: depletion of antioxidant defenses, accretion of oxidized proteins and impaired proteostasis.
Muscular Diseases
Plasma activity of pyruvate kinase and glutamic oxalacetic transaminase as indices of myopathy in the vitamin E deficient rat.
Muscular Diseases
Stereoisomers of alpha-tocopheryl acetate. III. Simultaneous determination of resorption-gestation and myopathy in rats as a means of evaluating biopotency ratios of all-rac- and RRR-alpha-tocopheryl acetate.
Muscular Diseases
Vitamin E activity of 1-thio-alpha-tocopherol as measured by the rat curative myopathy bioassay.
Muscular Diseases
[Pyruvate kinase deficiency of erythrocytes in a case of hereditary myopathy]
Muscular Dystrophies
A kindred with red cell pyruvate kinase deficiency.
Muscular Dystrophies
Blood plasma pyruvate kinase as a marker of muscular dystrophy. Properties in dystrophic chickens and hamsters.
Muscular Dystrophies
Carrier detection in X-linked recessive (Duchenne) muscular dystrophy: pyruvate kinase isoenzymes and creatine phosphokinase in serum and blood cells.
Muscular Dystrophies
Estimate of the intrafamilial correlation for serum creatine kinase and pyruvate kinase in females at risk for Duchenne and Becker muscular dystrophies.
Muscular Dystrophies
Pyruvate kinase and creatine phosphokinase during development of the chicken with muscular dystrophy.
Muscular Dystrophies
Pyruvate kinase isoenzymes in progressive muscular dystrophy and in acute myocardial infarction.
Muscular Dystrophies
Serum pyruvate kinase in carriers of Duochenne muscular dystrophy.
Muscular Dystrophies
Serum pyruvate kinase in different neuromuscular diseases and in carriers of muscular dystrophy.
Muscular Dystrophies
X chromosome-linked muscular dystrophy (mdx) in the mouse.
Muscular Dystrophies
[Evaluation of serum pyruvate kinase in patients with Duchenne's muscular dystrophy and carriers. Comparison with other enzyme determinations]
Muscular Dystrophies
[Serum enzyme dynamics in progressive muscular dystrophies]
Muscular Dystrophy, Duchenne
Decreased creatine kinase activity in cultured Duchenne dystrophic muscle cells.
Muscular Dystrophy, Duchenne
Detection of carriers of X-linked gene for Duchenne muscular dystrophy by levels of creatine kinase and pyruvate kinase.
Muscular Dystrophy, Duchenne
Duchenne muscular dystrophy carrier detection using logistic discrimination: serum creatine kinase, hemopexin, pyruvate kinase, and lactate dehydrogenase in combination.
Muscular Dystrophy, Duchenne
Estimates of conditional heterozygosity risks for young females in Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: implication for genetic risks estimates in Duchenne muscular dystrophy carriers.
Muscular Dystrophy, Duchenne
Improved detection of Duchenne muscular dystrophy heterozygotes using discriminant analysis of creatine kinase levels.
Muscular Dystrophy, Duchenne
Plasma pyruvate kinase and creatine kinase activity in Becker muscular dystrophy.
Muscular Dystrophy, Duchenne
Pyruvate kinase in fetal plasma and amniotic fluid unsuccessful for the prenatal diagnosis of Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Pyruvate kinase: diagnostic value in neuromuscular disease.
Muscular Dystrophy, Duchenne
Serum creatine kinase and pyruvate kinase in Duchenne muscular dystrophy carrier detection.
Muscular Dystrophy, Duchenne
Serum pyruvate kinase in carriers of Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Serum pyruvate kinase in carriers of Duochenne muscular dystrophy.
Muscular Dystrophy, Duchenne
[A study on the serum biochemistry in carrier detection of Duchenne muscular dystrophy]
Myelodysplastic Syndromes
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Myelodysplastic Syndromes
Erythrocyte enzyme activities in myelodysplastic syndromes: elevated pyruvate kinase activity.
Myelodysplastic Syndromes
Myelodysplastic syndrome in a patient with hereditary pyruvate kinase deficiency.
Myelolipoma
Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma.
Myocardial Infarction
HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction.
Myocardial Infarction
Pyruvate kinase isoenzymes in progressive muscular dystrophy and in acute myocardial infarction.
Myocardial Infarction
Serum enolase and pyruvate kinase activities in the diagnosis of myocardial infarction.
Myocardial Infarction
Serum pyruvate kinase in acute myocardial infarction.
Myocardial Infarction
[A clinical and experimental study on early diagnosis of myocardial infarct extension by measuring the activity of serum pyruvate kinase]
Myocardial Infarction
[Clinical significance of determining plasma pyruvate kinase (PK) activity in acute myocardial infarction (author's transl)]
Myocardial Infarction
[Pyruvate kinase in acute myocardial infarct]
Myocarditis
[Study of some properties of rat myocardial pyruvate kinase in adrenaline myocarditis]
Myositis
Dendritic cells presenting pyruvate kinase M1/M2 isozyme peptide can induce experimental allergic myositis in BALB/c mice.
Myotonic Dystrophy
Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy.
Nasopharyngeal Carcinoma
Suppressed "Warburg Effect" in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway.
Neoplasm Metastasis
A comparison of tumour M2-PK with carcinoembryonic antigen and CA19-9 in patients undergoing liver resection for colorectal metastases.
Neoplasm Metastasis
Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8.
Neoplasm Metastasis
Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation.
Neoplasm Metastasis
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Neoplasm Metastasis
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Neoplasm Metastasis
Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats.
Neoplasm Metastasis
Exploring targeted therapy of osteosarcoma using proteomics data.
Neoplasm Metastasis
Expression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis.
Neoplasm Metastasis
Glycolytic enzyme activities in breast cancer metastases.
Neoplasm Metastasis
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
Neoplasm Metastasis
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
Neoplasm Metastasis
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
Neoplasm Metastasis
Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK).
Neoplasm Metastasis
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
Neoplasm Metastasis
PKM2 in carcinogenesis and oncotherapy.
Neoplasm Metastasis
Plasma TuM2-PK correlates with tumor size, CRP and CA 15-3 in metastatic breast carcinomas; short versus long term follow up study of the Egyptian breast cancer patients.
Neoplasm Metastasis
Plasma Tumor M2-Pyruvate Kinase Levels in Different Cancer Types.
Neoplasm Metastasis
Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis.
Neoplasm Metastasis
Prognostic value of plasmatic tumor M2 pyruvate kinase and carcinoembryonic antigen in the survival of colorectal cancer patients.
Neoplasm Metastasis
Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.
Neoplasm Metastasis
Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling.
Neoplasm Metastasis
Pyruvate kinase type tumor M2 in urological malignancies.
Neoplasm Metastasis
Relationship between 18-F-fluoro-deoxy-D-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma.
Neoplasm Metastasis
Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway.
Neoplasm Metastasis
Suppressed "Warburg Effect" in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway.
Neoplasm Metastasis
The Value of Expression of M2-PK and VEGF in Patients with Advanced Gastric Cancer.
Neoplasm Metastasis
TUM2-PK (pyruvate kinase type tumor M2), CA19-9 and CEA in patients with benign, malignant and metastasizing pancreatic lesions.
Neoplasm Metastasis
Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma.
Neoplasm Metastasis
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
Neoplasms
1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Neoplasms
2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2.
Neoplasms
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Neoplasms
?-Catenin, a Wnt/?-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.
Neoplasms
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
Neoplasms
A cell engineering strategy to enhance the safety of stem cell therapies.
Neoplasms
A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2 Induced Glycolytic Reprogramming in Glioblastoma.
Neoplasms
A comparison of tumour M2-PK with carcinoembryonic antigen and CA19-9 in patients undergoing liver resection for colorectal metastases.
Neoplasms
A critical challenge in the development of antibody: Selecting the appropriate fragment of the target protein as an antigen based on various epitopes or similar structure.
Neoplasms
A critical review of the role of M2PYK in the Warburg effect.
Neoplasms
A fuzzy logic controller based approach to model the switching mechanism of the mammalian central carbon metabolic pathway in normal and cancer cells.
Neoplasms
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis.
Neoplasms
A novel miR-206/hnRNPA1/PKM2 axis reshapes the Warburg effect to suppress colon cancer growth.
Neoplasms
A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia.
Neoplasms
A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells.
Neoplasms
A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines.
Neoplasms
A pyruvate kinase variant in different mouse transplanted tumors.
Neoplasms
A useful EGFR-TK ligand for tumor diagnosis with SPECT: development of radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline.
Neoplasms
Aberrant Overexpression of Pyruvate Kinase M2 Is Associated With Aggressive Tumor Features and the BRAF Mutation in Papillary Thyroid Cancer.
Neoplasms
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.
Neoplasms
Action at a distance: allostery and the development of drugs to target cancer cell metabolism.
Neoplasms
Activators of PKM2 in cancer metabolism.
Neoplasms
Activity and inducibility of drug-metabolizing enzymes in immortalized hepatocyte-like cells (mhPKT) derived from a L-PK/Tag1 transgenic mouse.
Neoplasms
Activity of enzymes related to carbohydrate metabolism in the HT 29 colon adenocarcinoma cell line and tumor.
Neoplasms
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in lipoblastic and neurogenic proliferations.
Neoplasms
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Neoplasms
Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.
Neoplasms
Advances in the proteomic discovery of novel therapeutic targets in cancer.
Neoplasms
Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms.
Neoplasms
Affinity elution of pyruvate kinase from phosphocellulose.
Neoplasms
Age-related faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers.
Neoplasms
Age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis and healthy children 0 to 10years old.
Neoplasms
AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth.
Neoplasms
Alanine-mediated reversible inactivation of tumour pyruvate kinase caused by a tetramer-dimer transition.
Neoplasms
Alterations in erythrocyte enzymes in cancer.
Neoplasms
Alterations in glucose metabolism proteins responsible for the Warburg effect in esophageal squamous cell carcinoma.
Neoplasms
Altered glycolysis results in drug-resistant in clinical tumor therapy.
Neoplasms
Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.
Neoplasms
Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.
Neoplasms
Anti-cancer effect of a novel 2,3-didithiocarbamate-substituted naphthoquinone as a tumor metabolic suppressor in vitro and in vivo.
Neoplasms
Antigen presentation by dendritic cells in tumors is disrupted by altered metabolism that involves pyruvate kinase M2 and its interaction with SOCS3.
Neoplasms
Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes.
Neoplasms
Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8.
Neoplasms
Antitumor effect of metformin on cholangiocarcinoma: In vitro and in vivo studies.
Neoplasms
Antitumor Effect of Shikonin, a PKM2 Inhibitor, in Cholangiocarcinoma Cell Lines.
Neoplasms
Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis.
Neoplasms
Assessment of the low inhibitory specificity of oxamate, aminooxyacetate and dichloroacetate on cancer energy metabolism.
Neoplasms
Association-dissociation behavior of erythrocyte phosphofructokinase and tumor pyruvate kinase.
Neoplasms
Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation.
Neoplasms
Biochemical alterations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors from rats subjected to caloric restriction.
Neoplasms
Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2.
Neoplasms
Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer.
Neoplasms
Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment.
Neoplasms
Caging of plumbagin on silver nanoparticles imparts selectivity and sensitivity to plumbagin for targeted cancer cell apoptosis.
Neoplasms
Cancer abolishes the tissue type-specific differences in the phenotype of energetic metabolism.
Neoplasms
Cancer cell metabolism: implications for therapeutic targets.
Neoplasms
Cancer metabolism and mass spectrometry-based proteomics.
Neoplasms
Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator.
Neoplasms
Cancer metabolism: what we can learn from proteomic analysis by mass spectrometry.
Neoplasms
Carbohydrate metabolism in neoplastic tissue.
Neoplasms
Catalytic and regulatory properties of muscle pyruvate kinase from Cancer magister.
Neoplasms
Cellular expression of K-type pyruvate kinase in normal and neoplastic human tissues.
Neoplasms
Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling.
Neoplasms
Changes in PKM2 associate with prostate cancer progression.
Neoplasms
Changes in the pyruvate kinase and lactate dehydrogenase activity in rat lung during cultivation and "spontaneous" development of malignancy in vitro.
Neoplasms
Characterization of pyruvate kinase from human rhabdomyosarcoma in relation to immunohistochemical and morphological criteria.
Neoplasms
Characterization of some glycolytic enzymes from human retina and retinoblastoma.
Neoplasms
CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma.
Neoplasms
Chromosomal assignment of seven genes on canine chromosomes by fluorescence in situ hybridization.
Neoplasms
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Neoplasms
Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.
Neoplasms
Clinical significance of serum tumour M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma.
Neoplasms
Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹?F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors.
Neoplasms
Clinicopathological and prognostic significance of PKM2 protein expression in cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma.
Neoplasms
Co-expression of PKM2 and TRIM35 predicts survival and recurrence in hepatocellular carcinoma.
Neoplasms
Colorectal cancer detection by biomarker quantification in noninvasively collected colorectal mucus: preliminary comparison of 24 protein biomarkers.
Neoplasms
Colorectal cancer detection in an asymptomatic population: fecal immunochemical test for hemoglobin vs. fecal M2-type pyruvate kinase.
Neoplasms
Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK.
Neoplasms
Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity.
Neoplasms
Comparison of a novel fecal marker--fecal tumor pyruvate kinase type M2 (M2-PK) with fecal calprotectin in patients with inflammatory bowel disease: a prospective study.
Neoplasms
Comparison of an established simple office-based immunological FOBT with fecal tumor pyruvate kinase type M2 (M2-PK) for colorectal cancer screening: prospective multicenter study.
Neoplasms
Comparison of faecal M2-PK and FIT in a population-based bowel cancer screening cohort.
Neoplasms
Comparison of Plasma Tu-M2-PK and CA19-9 in Pancreatic Cancer.
Neoplasms
Comparison of pyruvate kinase variants from breast tumor and normal breast.
Neoplasms
Comparison of pyruvate kinase variants from rat liver and Morris hepatoma 7777, obtained by an affinity chromatography on blue sepharose CL-6B.
Neoplasms
Comparison of the tumor markers tumor M2-PK, CEA, CYFRA 21-1, NSE and SCC in the diagnosis of lung cancer.
Neoplasms
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Neoplasms
Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia.
Neoplasms
Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response.
Neoplasms
Correlation between Faecal Tumour M2 Pyruvate Kinase and Colonoscopy for the Detection of Adenomatous Neoplasia in a Secondary Care Cohort.
Neoplasms
Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism.
Neoplasms
Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1? inhibition.
Neoplasms
Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy.
Neoplasms
Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2.
Neoplasms
DAPk and pyruvate kinase: unlikely partners in cancer metabolic regulation.
Neoplasms
Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase.
Neoplasms
Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth.
Neoplasms
Determination of faecal inflammatory marker concentration as a noninvasive method of evaluation of pathological activity in children with inflammatory bowel diseases.
Neoplasms
Determination of pyruvate kinase type tumor M2 in human renal cell carcinoma: a suitable tumor marker?
Neoplasms
Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors.
Neoplasms
Development of [
Neoplasms
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Neoplasms
Diagnostic Accuracy of Five Different Fecal Markers for the Detection of Precancerous and Cancerous Lesions of the Colorectum.
Neoplasms
Diagnostic and prognostic value of plasma tumor M2 pyruvate kinase in periampullary cancer: evidence for a novel biological marker of adverse prognosis.
Neoplasms
Diagnostic and prognostic value of tumor M2-pyruvate kinase levels in patients with colorectal canhcer.
Neoplasms
Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: A systematic review and meta-analysis.
Neoplasms
Diagnostic Value of Pyruvate Kinase Isoenzyme Type M2 in Colon Cancer Proven with Colonoscopy.
Neoplasms
Diagnostic value of tumor M2-pyruvate kinase in neuroendocrine tumors. A comparative study with chromogranin A.
Neoplasms
Diet-dependent carcinogenesis of pancreatic islets and liver in transgenic mice expressing oncogenes under the control of the L-type pyruvate kinase gene promoter.
Neoplasms
Dietary fructose improves intestinal cell survival and nutrient absorption.
Neoplasms
Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer.
Neoplasms
Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats.
Neoplasms
Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies.
Neoplasms
Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme.
Neoplasms
Differential proteomic profiling of chordomas and analysis of prognostic factors.
Neoplasms
Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis.
Neoplasms
Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis.
Neoplasms
Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators.
Neoplasms
Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator.
Neoplasms
Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing.
Neoplasms
Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers.
Neoplasms
Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase.
Neoplasms
Discrimination between neuronal and glial cell tumours by pyruvate kinase electrophoresis.
Neoplasms
DNA Methylation of Cannabinoid Receptor Interacting Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination.
Neoplasms
Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells.
Neoplasms
Downregulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis.
Neoplasms
Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth.
Neoplasms
Effect of cyclic polylactates on tumor cells and tumor bearing mice.
Neoplasms
Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer.
Neoplasms
Effects of cyclic polylactate (CPL) on the growth of cloned leukemic cells in vitro.
Neoplasms
Effects of L-alanine and fructose (1,6-diphosphate) on pyruvate kinase from ehrlich ascites tumour cells.
Neoplasms
Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex.
Neoplasms
Efficacy and mechanism of combination of oxaliplatin with PKM2 knockdown in colorectal cancer.
Neoplasms
Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model.
Neoplasms
Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients.
Neoplasms
EGFR-induced and PKC? monoubiquitylation-dependent NF-?B activation upregulates PKM2 expression and promotes tumorigenesis.
Neoplasms
Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.
Neoplasms
Elevated faecal M2-pyruvate kinase in children with cystic fibrosis: A clue to the increased risk of intestinal malignancy in adulthood?
Neoplasms
Emerging roles of PKM2 in cell metabolism and cancer progression.
Neoplasms
Endothelial pyruvate kinase M2 maintains vascular integrity.
Neoplasms
Enhanced expression of PKM2 associates with the biological properties of cancer stem cells from A549 human lung cancer cells.
Neoplasms
Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.
Neoplasms
Enhanced patterns on intraoperative contrast-enhanced ultrasonography predict outcomes after curative liver resection in patients with hepatocellular carcinoma.
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Enhanced penetration and cytotoxicity of metformin and collagenase conjugated gold nanoparticles in breast cancer spheroids.
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Enhancing Mitochondrial Respiration Suppresses Tumor Promoter TPA Induced PKM2 Expression and Cell Transformation in Skin Epidermal JB6 Cells.
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Enzyme activities and isozyme patterns in human lung tumors.
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Enzyme activities in normal, dysplastic, and cancerous human breast tissues.
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Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
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Enzyme Kinetic Assay to Measure the Activity of Tumor M2 Pyruvate Kinase in Breast Cancer Patients.
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Enzymes in cancer. I. Measurement of pyruvate kinase in serum of normal individuals and patients with cancer.
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Enzymes of glucose metabolism in carcinoma of the cervix and endometrium of the human uterus.
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Epigenetic silencing of miR-338 facilitates glioblastoma progression by de-repressing the pyruvate kinase M2-?-catenin axis.
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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
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Erythrocyte pyruvate kinase activity in patients with haematological malignancies.
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Establishment of renal proximal tubule cell lines by targeted oncogenesis in transgenic mice using the L-pyruvate kinase-SV40 (T) antigen hybrid gene.
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Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase isozymes and status of host lipids.
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Evaluation of experimental liver tumors using fluorine-18-2-fluoro-2-deoxy-D-glucose PET.
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Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [18F]DASA-23.
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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
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Evaluation of the antiproliferative activity of 106 marine microbial metabolites against human lung cancer cells and potential antiproliferative mechanism of purpuride G.
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Evaluation of the Performance of a Fecal Tumor M2-PK Rapid Kit Using Stool Specimens for Detection of Colorectal Tumors.
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Evaluation of the Pyruvate Kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for cervical carcinoma.
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Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
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Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer.
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Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
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Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons.
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Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer.
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Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2.
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Exploring the Altered Dynamics of Mammalian Central Carbon Metabolic Pathway in Cancer Cells: A Classical Control Theoretic Approach.
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Expression of a new set of glycolytic isozymes in activated human peripheral lymphocytes.
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Expression of glucose transporter isoforms (GLUT1, GLUT2) and activities of hexokinase, pyruvate kinase, and malic enzyme in preneoplastic and neoplastic rat renal basophilic cell lesions.
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Expression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis.
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Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value.
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Expression of tumor pyruvate kinase M2 isoform in plasma and stool of patients with colorectal cancer or adenomatous polyps.
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Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway.
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Extraction of a factor from Ehrlich ascites tumor cells that increases the activity of the fetal isozyme of pyruvate kinase in mouse liver.
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Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention.
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Faecal M2-pyruvate kinase: a novel, noninvasive marker of ileal pouch inflammation.
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Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer.
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Faecal tumour pyruvate kinase M2: not a good marker for the detection of colorectal adenomas.
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Fecal dimeric M2-pyruvate kinase (tumor M2-PK) in the differential diagnosis of functional and organic bowel disorders.
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Fecal Markers of Inflammation and Disease Activity in Paediatric Crohn's Disease: Results from the ImageKids Study.
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Fecal pyruvate kinase concentrations (ELISA based on a combination of clone 1 and clone 3 antibodies) for gastric cancer screening.
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Fecal pyruvate kinase-M2 (tumor M2-PK) measurement: a new screening concept for colorectal cancer.
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Fecal tumor M2 pyruvate kinase is not a specific biomarker for colorectal cancer screening.
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FFJ-3 inhibits PKM2 protein expression via the PI3K/Akt signaling pathway and activates the mitochondrial apoptosis signaling pathway in human cancer cells.
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Flavonoids Targeting HIF-1: Implications on Cancer Metabolism.
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Follicle-stimulating hormone promoted pyruvate kinase isozyme type M2-induced glycolysis and proliferation of ovarian cancer cells.
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From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity.
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Fuzzy logic-based tumor marker profiles improved sensitivity of the detection of progression in small-cell lung cancer patients.
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Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
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Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes.
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Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.
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Gluconeogenic control adaptations in Cancer magister: hypodermal pyruvate kinase, an enzyme with high- and low-affinity states.
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Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited.
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Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.
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Glucose metabolism and angiogenesis in granulosa cell tumors of the ovary: activation of Akt, expression of M2PK, TKTL1 and VEGF.
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Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues.
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Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical carcinoma.
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Glycolytic enzyme activities in breast cancer metastases.
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Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated Leukemia.
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Glycolytic enzymes from human neuroectodermal tumors of childhood.
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Hepatic glucose-6-phosphatase-? deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.
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Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
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High expression of PKM2 synergizes with PD-L1 in tumor cells and immune cells to predict worse survival in human lung adenocarcinoma.
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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
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HSP40 Interacts with Pyruvate Kinase M2 and Regulates Glycolysis and Cell Proliferation in Tumor Cells.
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HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
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Human steroid sulfatase enhances aerobic glycolysis through induction of HIF1? and glycolytic enzymes.
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Identification of cytotoxic mediators and their putative role in the signaling pathways during docosahexaenoic acid (DHA)-induced apoptosis of cancer cells.
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Identification of Differentiation-Related Proteins in Gastric Adenocarcinoma Tissues by Proteomics.
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Identification of five candidate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines.
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Identification of Gliotoxin isolated from marine fungus as a new pyruvate kinase M2 inhibitor.
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Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling.
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Identification of small molecule inhibitors of pyruvate kinase M2.
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Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Lower Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.
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Immunohistochemical localization of pyruvate kinase isoenzymes in chicken tissues.
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Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat.
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Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response.
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Impact of butyrate on PKM2 and HSP90? expression in human colon tissues of different transformation stages: a comparison of gene and protein data.
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Impact of quaternary structure dynamics on allosteric drug discovery.
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Improved sensitivity in the diagnosis of gastro-intestinal tumors by fuzzy logic-based tumor marker profiles including the tumor M2-PK.
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In silico investigation of potential pyruvate kinase M2 regulators from traditional Chinese medicine against cancers.
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In vitro inhibitory effect of chitosan and its degradation products on energy metabolism in Ehrlich ascites tumour cells (EAT).
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In vivo factors influencing tumour M2-pyruvate kinase level in human pancreatic cancer cell lines.
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Induction of apoptosis by FFJ-5, a novel naphthoquinone compound, occurs via downregulation of PKM2 in A549 and HepG2 cells.
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Influence of insulin on estrogen-induced responses in the r3230ac mammary carcinoma.
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Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
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Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer.
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Inhibition of Non-flux-Controlling Enzymes Deters Cancer Glycolysis by Accumulation of Regulatory Metabolites of Controlling Steps.
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Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis.
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Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2.
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Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2.
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Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors.
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Interaction of M1 and M2 isozymes pyruvate kinase from human tissues with phospholipids.
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Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer.
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Interconversion phenomena between two kinetic forms of class a pyruvate kinase from Ehrlich ascites tumor cells.
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Interconvertible forms of class A pyruvate kinase from Ehrlich ascites tumour cells.
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Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.
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Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review.
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Isoform switch of pyruvate kinase m1 indeed occurs but not to pyruvate kinase m2 in human tumorigenesis.
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Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using subtractive hybridization.
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Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation.
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Isozyme patterns of normal, benign, and malignant human breast tissues.
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Isozyme patterns of pyruvate kinase in various primary liver tumors induced during the process of hepatocarcinogenesis.
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JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1?-mediated glucose metabolism.
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Kinetic properties of pyruvate kinase isolated from rat hepatic tumours.
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Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells.
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Knockdown of PKM2 Enhances Radiosensitivity of Non-small cell Lung Cancer.
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Knockdown of PKM2 induces apoptosis and autophagy in human A549 alveolar adenocarcinoma cells.
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Knockdown of PKM2 suppresses tumor progression in human cervical cancer by modulating epithelial-mesenchymal transition via Wnt/?-catenin signaling.
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Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma.
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Knockdown of pyruvate kinase type M2 suppresses tumor survival and invasion in osteosarcoma cells both in vitro and in vivo.
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L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
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L-alpha-alanine inhibition of pyruvate kinase from tumors of the human central nervous system.
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Lactate does not activate NF-?B in oxidative tumor cells.
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Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2.
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Lapatinib Inhibits Breast Cancer Cell Proliferation by Influencing PKM2 Expression.
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Limited Clinical Significance of Dimeric Form of Pyruvate Kinase as a Diagnostic and Prognostic Biomarker in Non-small Cell Lung Cancer.
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Long noncoding RNA MALAT1 mediates stem cell-like properties in human colorectal cancer cells by regulating miR-20b-5p/Oct4 axis.
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Loss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer.
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M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.
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M2-PK as a novel marker in ovarian cancer. A prospective cohort study.
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Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
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Mangifera indica Extracts as Novel PKM2 Inhibitors for Treatment of Triple Negative Breast Cancer.
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Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides.
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Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK).
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Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.
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Metabolic characterization of three hamster melanoma variants.
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Metabolic control of glycolysis in normal and tumor permeabilized cells.
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Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.
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Metabolic modulation of cancer: a new frontier with great translational potential.
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Metabolic Pathway Alterations that Support Cell Proliferation.
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Metabolic signature genes associated with susceptibility to Pyruvate kinase, muscle type 2 gene ablation in cancer cells.
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Metabolic vulnerabilities in endometrial cancer.
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Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry.
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Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.
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MicroRNA 675 cooperates PKM2 to aggravate progression of human liver cancer stem cells induced from embryonic stem cells.
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MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in gastric cancer.
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Missense mutations in pyruvate kinase m2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner.
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Mitochondria, hexokinase and pyruvate kinase isozymes in the aerobic glycolysis of tumor cells.
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Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2.
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Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASN.
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Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms.
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Moderate DNA damage promotes metabolic flux into PPP via PKM2 Y-105 phosphorylation: a feature that favours cancer cells.
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Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells.
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Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells.
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Molecular docking analysis of pyruvate kinase M2 with a potential inhibitor from the ZINC database.
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Molecular simulation of Tyr105 phosphorylated pyruvate kinase M2 to understand its structure and dynamics.
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MUC1-C oncoprotein regulates glycolysis and pyruvate kinase m2 activity in cancer cells.
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Multiple reaction monitoring of mTRAQ-labeled peptides enables absolute quantification of endogenous levels of a potential cancer marker in cancerous and normal endometrial tissues.
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Mutant p53 and mTOR/PKM2 regulation in cancer cells.
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N-acetylneuraminic acid, phosphate and thiol groups of pyruvate kinase isoenzymes from Morris hepatoma 7777 and normal rat liver.
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Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment.
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Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.
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NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase.
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New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
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New faecal tests in gastroenterology.
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New links between lipid accumulation and cancer progression.
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New roles for pyruvate kinase M2: working out the Warburg effect.
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Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways.
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Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein.
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Nuclear accumulation of pyruvate kinase M2 promotes liver regeneration via activation of signal transducer and activator of transcription 3.
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Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2.
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Nuclear PKM2 regulates ?-catenin transactivation upon EGFR activation.
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Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress.
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Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.
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O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.
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Oleanolic Acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type m isoforms.
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On the Origin of ATP Synthesis in Cancer.
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Oncogenic kinase-induced PKM2 tyrosine 105 phosphorylation converts non-oncogenic PKM2 to a tumor promoter and induces cancer stem-like cells.
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Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.
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Optimization of a modeling platform to predict oncogenes from genome-scale metabolic networks of non-small-cell lung cancers.
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Overexpression of metabolic markers HK1 and PKM2 contributes to lymphatic metastasis and adverse prognosis in Chinese gastric cancer.
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Overexpression of metabolic markers PKM2 and LDH5 correlates with aggressive clinicopathological features and adverse patient prognosis in tongue cancer.
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Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.
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Overexpression of Pyruvate Kinase M2 in Tumor Tissues Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma.
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Overexpression of pyruvate kinase M2 predicts a poor prognosis for patients with osteosarcoma.
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Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.
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Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2.
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Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
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PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2.
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Phage display library selection of a hypoxia-binding scFv antibody for liver cancer metabolic marker discovery.
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Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
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Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1.
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Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2.
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Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
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Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer.
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Phylogeny congruence analysis and isozyme classification: the pyruvate kinase system.
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Phytometabolites Targeting Warburg Effect in Cancer Cells: A Mechanistic Review.
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PK-M2 Makes Cells Sweeter on HIF1.
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PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.
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PKM1 is involved in resistance to anti-cancer drugs.
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PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.
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PKM2 and cancer: The function of PKM2 beyond glycolysis.
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PKM2 and HIF-1? regulation in prostate cancer cell lines.
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PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer.
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PKM2 enhances chemosensitivity to cisplatin through interaction with the mTOR pathway in cervical cancer.
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PKM2 in Canine Mammary Tumors: Parallels to Human Breast Cancer.
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PKM2 in carcinogenesis and oncotherapy.
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PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells.
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PKM2 is not required for colon cancer initiated by APC loss.
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PKM2 is not required for pancreatic ductal adenocarcinoma.
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PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
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PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.
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PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma.
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PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop.
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PKM2 promotes glucose metabolism through a let-7a-5p/Stat3/hnRNP-A1 regulatory feedback loop in breast cancer cells.
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PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation.
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PKM2 promotes tumor angiogenesis by regulating HIF-1? through NF-?B activation.
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PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma.
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PKM2 regulates proliferation and apoptosis through the Hippo pathway in oral tongue squamous cell carcinoma.
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PKM2 Thr454 phosphorylation increases its nuclear translocation and promotes xenograft tumor growth in A549 human lung cancer cells.
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PKM2 under hypoxic environment causes resistance to mTOR inhibitor in human castration resistant prostate cancer.
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PKM2 upregulation promotes malignancy and indicates poor prognosis for intrahepatic cholangiocarcinoma.
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PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.
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PKM2, a potential target for regulating cancer.
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PKM2, cancer metabolism, and the road ahead.
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PKM2, function and expression and regulation.
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PKM2, STAT3 and HIF-1?: The Warburg's vicious circle.
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PKM2-dependent glycolysis promotes the proliferation and migration of vascular smooth muscle cells during atherosclerosis.
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PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-?1-induced EMT.
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PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
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PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancer.
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Plasma concentrations of tumour dimeric pyruvate kinase are increased in patients with chronic cardiac failure.
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Plasma levels of HER-2/neu, tumor type M2 pyruvate kinase and its tyrosine-phosphorylated metabolite in advanced breast cancer.
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Plasma levels of tumor M2-pyruvate kinase should not be used as a tumor marker for hematological malignancies and solid tumors.
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Plasma TM2-PK levels in mycosis fungoides patients.
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Plasma TuM2-PK correlates with tumor size, CRP and CA 15-3 in metastatic breast carcinomas; short versus long term follow up study of the Egyptian breast cancer patients.
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Plasma Tumor M2-Pyruvate Kinase Levels in Different Cancer Types.
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Point-of-care testing in the diagnosis of gastrointestinal cancers: current technology and future directions.
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Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered.
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Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer.
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Potential adverse effects to the retina of cancer therapy targeting pyruvate kinase M2.
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Power of screening tests for colorectal cancer enhanced by high levels of M2-PK in addition to FOBT.
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Pre-analytical problems in the measurement of tumor type pyruvate kinase (tumor M2-PK).
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Predicting the clinical course of breast cancer patients undergoing trastuzumab-based therapy: an outlook.
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Probing Metabolism in the Intact Retina Using Stable Isotope Tracers.
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Prognostic role of glycolysis for cancer outcome: evidence from 86 studies.
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Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
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Prognostic significance of metabolic enzyme pyruvate kinase M2 in breast cancer: A meta-analysis.
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Prognostic Significance of O-GlcNAc and PKM2 in Hormone Receptor-Positive and HER2-Nonenriched Breast Cancer.
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Prognostic value of plasmatic tumor M2 pyruvate kinase and carcinoembryonic antigen in the survival of colorectal cancer patients.
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Proliferative activity in hepatocellular carcinoma is closely correlated with glucose metabolism but not angiogenesis.
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Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma.
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Prospective multicenter evaluation of fecal tumor pyruvate kinase type M2 (M2-PK) as a screening biomarker for colorectal neoplasia.
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Protein kinase CK2 modulation of pyruvate kinase M isoforms augments the Warburg effect in cancer cells.
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Protein kinase function of pyruvate kinase M2 and cancer.
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Proteomic analysis of the effects of tetramethylpyrazine on irradiated QXMSC1 cells.
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Proteomic analysis of tumor tissue in CT-26 implanted BALB/C mouse after treatment with ascorbic acid.
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Proteomic identification of the differentially expressed proteins in human lung epithelial cells by airborne particulate matter.
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Proteomic profiling of high risk medulloblastoma reveals functional biology.
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Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells.
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Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex.
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Purification of pyruvate kinase from Yoshida ascites tumor cells.
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Purification of pyruvate kinase isoenzymes type M1 and M2 from dog (Canis familiaris) and comparison of their properties with those from chicken and rat.
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Purified pyruvate kinases type M2 from unfertilized hen's egg are substrates of protein kinase C.
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Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology.
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Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.
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Pyruvate kinase and phosphofructokinase isozymes in childhood cancers.
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Pyruvate kinase and the interaction of amino acid and carbohydrate metabolism in solid tumors.
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Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
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Pyruvate kinase from cytosolic fractions of the Ehrlich ascites tumour, normal mouse liver and skeletal muscle.
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Pyruvate kinase in normal human thyroid tissue and thyroid neoplasms.
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Pyruvate kinase inhibition in the diagnosis of gliomas with an intermediate degree of malignancy.
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Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis.
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Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells.
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Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer.
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Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet.
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Pyruvate kinase isoenzymes in chromatin extracts of Ehrlich ascites tumour, Morris hepatoma 7777 and normal mouse and rat livers.
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Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
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Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells.
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Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription.
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Pyruvate kinase isozymes and dedifferentiation of (neuro-)ectodermal tumors.
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Pyruvate kinase isozymes in various tissues of rat, and increase of spleen-type pyruvate kinase in liver by injecting chromatins from spleen and tumor.
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Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.
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Pyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysis.
Neoplasms
Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics.
Neoplasms
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Neoplasms
Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1? and Bcl-xL in culture.
Neoplasms
Pyruvate kinase M2 and cancer: an updated assessment.
Neoplasms
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis.
Neoplasms
Pyruvate kinase M2 and its evolving role as a prognostic marker in systemic malignancies besides colorectal carcinomas.
Neoplasms
Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome.
Neoplasms
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Neoplasms
Pyruvate kinase M2 at a glance.
Neoplasms
Pyruvate Kinase M2 Coordinates Metabolism Switch between Glycolysis and Glutaminolysis in Cancer Cells.
Neoplasms
Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.
Neoplasms
Pyruvate Kinase M2 Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer That Is Associated with Poor Outcomes in Endometrial Carcinoma.
Neoplasms
Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling.
Neoplasms
Pyruvate kinase M2 in blood circulation facilitates tumor growth by promoting angiogenesis.
Neoplasms
Pyruvate kinase M2 in chronic inflammations: a potpourri of crucial protein-protein interactions.
Neoplasms
Pyruvate kinase M2 inhibits the progression of bladder cancer by targeting MAKP pathway.
Neoplasms
Pyruvate kinase M2 interacts with DNA damage-binding protein 2 and reduces cell survival upon UV irradiation.
Neoplasms
Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer.
Neoplasms
Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Neoplasms
Pyruvate kinase M2 is highly correlated with the differentiation and the prognosis of esophageal squamous cell cancer.
Neoplasms
Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.
Neoplasms
Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration.
Neoplasms
Pyruvate Kinase M2 Knockdown Suppresses Migration, Invasion, and Epithelial-Mesenchymal Transition of Gastric Carcinoma via Hypoxia-Inducible Factor Alpha/B-Cell Lymphoma 6 Pathway.
Neoplasms
Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway.
Neoplasms
Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis.
Neoplasms
Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies.
Neoplasms
Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells.
Neoplasms
Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.
Neoplasms
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.
Neoplasms
Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling.
Neoplasms
Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells.
Neoplasms
Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair.
Neoplasms
Pyruvate kinase M2 regulates photoreceptor structure, function, and viability.
Neoplasms
Pyruvate Kinase M2 serves as blockade for nucleosome repositioning and abrogates Chd7 remodeling activity.
Neoplasms
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression.
Neoplasms
Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment.
Neoplasms
Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression.
Neoplasms
Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.
Neoplasms
Pyruvate Kinase Muscle Isoenzyme 2 (PKM2) Expression Is Associated with Overall Survival in Pancreatic Ductal Adenocarcinoma.
Neoplasms
Pyruvate kinase type M2 and its role in tumor growth and spreading.
Neoplasms
Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells.
Neoplasms
Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.
Neoplasms
Pyruvate kinase type M2: a crossroad in the tumor metabolome.
Neoplasms
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells.
Neoplasms
Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours.
Neoplasms
Pyruvate kinase type tumor M2 in urological malignancies.
Neoplasms
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Neoplasms
Pyruvate kinase: Function, regulation and role in cancer.
Neoplasms
Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas.
Neoplasms
Quantitative detection of tumor M2-PK in serum and plasma.
Neoplasms
Quantitative detection of tumor M2-pyruvate kinase in plasma of patients with lung cancer in comparison to other lung diseases.
Neoplasms
Quantitative determination of the degree of differentiation of mammary tumors by pyruvate kinase kinetic analysis.
Neoplasms
Rat hyperplastic hepatic nodules and primary hepatomas retaining abnormally high pyruvate kinase L type activity.
Neoplasms
Rationalization of the Activity Profile of Pyruvate Kinase Isozyme M2 (PKM2) Inhibitors using 3D QSAR.
Neoplasms
Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy.
Neoplasms
Regulation and function of pyruvate kinase M2 in cancer.
Neoplasms
Regulation of glycolysis and oxygen consumption in lymph-node cells of normal and leukaemic mice.
Neoplasms
Regulation of Metabolism by Hypoxia-Inducible Factor 1.
Neoplasms
Regulatory circuit of PKM2/NF-?B/miR-148a/152-modulated tumor angiogenesis and cancer progression.
Neoplasms
Relationship between 18-F-fluoro-deoxy-D-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma.
Neoplasms
Reply: Faecal tumour pyruvate kinase M2: not a good marker for detection of colorectal adenomas.
Neoplasms
Reply: New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
Neoplasms
Repression of cellular anaplerosis as the hypothesized mechanism of gamma-linolenic acid-induced toxicity to tumor cells.
Neoplasms
Resurgence of fetal isozymes in cancer: study of aldolase, pyruvate kinase, lactic dehydrogenase, and beta-hexosaminidase.
Neoplasms
Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.
Neoplasms
Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin.
Neoplasms
RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion.
Neoplasms
Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.
Neoplasms
Role of sp transcription factors in the regulation of cancer cell metabolism.
Neoplasms
SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions.
Neoplasms
Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing.
Neoplasms
SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing.
Neoplasms
Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/?-catenin pathway in colon cancer cells.
Neoplasms
Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study.
Neoplasms
Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells.
Neoplasms
Serum depletion induces changes in protein expression in the trophoblast-derived cell line HTR-8/SVneo.
Neoplasms
Serum tumour M2-pyruvate kinase as a biomarker for diagnosis and prognosis of early-stage non-small cell lung cancer.
Neoplasms
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1? to overcome apoptosis in a refractory HCC cell line.
Neoplasms
Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis.
Neoplasms
Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation.
Neoplasms
Shikonin, vitamin K3 and vitamin K5 inhibit multiple glycolytic enzymes in MCF-7 cells.
Neoplasms
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Neoplasms
Short-chain lipid peroxidation products form covalent adducts with pyruvate kinase and inhibit its activity in vitro and in breast cancer cells.
Neoplasms
Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice.
Neoplasms
Similarities between pyruvate kinase from human placenta and tumours.
Neoplasms
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.
Neoplasms
Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.
Neoplasms
Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis.
Neoplasms
Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells.
Neoplasms
Small-molecule reprogramming of cancer metabolism.
Neoplasms
Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway in Ovarian Cancer Cells.
Neoplasms
Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment.
Neoplasms
Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.
Neoplasms
SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells.
Neoplasms
Stimulation of tumor-cell respiration by inhibitors of pyruvate kinase.
Neoplasms
STIP1 down-regulation inhibits glycolysis by suppressing PKM2 and LDHA and inactivating the Wnt/?-catenin pathway in cervical carcinoma cells.
Neoplasms
Structural and kinetic differences between the M2 type pyruvate kinases from lung and various tumors.
Neoplasms
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation.
Neoplasms
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation.
Neoplasms
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.
Neoplasms
Structural insight into mechanisms for dynamic regulation of PKM2.
Neoplasms
Study of pyruvate kinase activity in human astrocytomas - Alanine-inhibition test revisted.
Neoplasms
Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapy response in vitro and in vivo mouse model of human non-small-cell lung cancer.
Neoplasms
Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5'-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form.
Neoplasms
Suppressed "Warburg Effect" in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway.
Neoplasms
Synergistic Allosteric Mechanism of Fructose-1,6-bisphosphate and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network Analysis.
Neoplasms
Synergistic combination of gemcitabine and dietary molecule induces apoptosis in pancreatic cancer cells and down regulates PKM2 expression.
Neoplasms
Synergistic effect of ammonium and potassium ions on pyruvate kinase from Ehrlich ascites tumor cells.
Neoplasms
Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors.
Neoplasms
Synthesis of novel sulfonamide derivatives containing pyridin-3-ylmethyl 4-(benzoyl)piperazine-1-carbodithioate moiety as potent PKM2 activators.
Neoplasms
Tanshinone ?A inhibits human esophageal cancer cell growth through miR-122-mediated PKM2 down-regulation.
Neoplasms
Targeting cancer metabolism.
Neoplasms
Targeting cellular metabolism to improve cancer therapeutics.
Neoplasms
Targeting PKM2 promotes chemosensitivity of breast cancer cells in vitro and in vivo.
Neoplasms
Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer.
Neoplasms
Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo.
Neoplasms
Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes.
Neoplasms
Targeting pyruvate kinase muscle isoform 2 (PKM2) in cancer: What do we know so far?
Neoplasms
TEPP-46-Based AIE Fluorescent Probe for Detection and Bioimaging of PKM2 in Living Cells.
Neoplasms
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.
Neoplasms
The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer.
Neoplasms
The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
Neoplasms
The Diagnostic Value of Pyruvate Kinase Isoenzyme Type M2 for Biliary Tract Carcinoma. A Systematic Review and Meta-Analysis.
Neoplasms
The dual activity of pyruvate kinase type M2 from chromatin extracts of neoplastic cells.
Neoplasms
The effect of levamisole on energy metabolism in Ehrlich ascites tumour cells in vitro.
Neoplasms
The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer.
Neoplasms
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Neoplasms
The impairment of respiration by glycolysis in the Lewis lung carcinoma.
Neoplasms
The inhibitory effect of L-cysteine and its derivatives on glycolysis in Ehrlich ascites tumour cells.
Neoplasms
The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells.
Neoplasms
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
Neoplasms
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Neoplasms
The M2-type isoenzyme of pyruvate kinase phosphorylates prothymosin ? in proliferating lymphocytes.
Neoplasms
The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells.
Neoplasms
The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.
Neoplasms
The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus.
Neoplasms
The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma.
Neoplasms
The multifaceted regulation and functions of PKM2 in tumor progression.
Neoplasms
The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells.
Neoplasms
The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma.
Neoplasms
The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma.
Neoplasms
The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose.
Neoplasms
The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy.
Neoplasms
The role of pyruvate kinase M2 in anticancer therapeutic treatments.
Neoplasms
The Role of Pyruvate Kinase M2 in Cancer Metabolism.
Neoplasms
The role of the HIF-1?/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer.
Neoplasms
The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2.
Neoplasms
The synthetic oleanane triterpenoid CDDO-Me binds and inhibits pyruvate kinase M2.
Neoplasms
The tumor marker tumor M2-PK: an application in the diagnosis of gastrointestinal cancer.
Neoplasms
The tumor metabolome.
Neoplasms
The use of M2-pyruvate kinase as a stool biomarker for detection of colorectal cancer in tertiary teaching hospital: A comparative study.
Neoplasms
The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test.
Neoplasms
The Utility of [18F]DASA-23 for Molecular Imaging of Prostate Cancer with Positron Emission Tomography.
Neoplasms
The Value of Expression of M2-PK and VEGF in Patients with Advanced Gastric Cancer.
Neoplasms
The value of fecal tumor M2 pyruvate kinase as a diagnostic tool for colorectal cancer screening.
Neoplasms
The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina.
Neoplasms
The Warburg Effect, Lactate, and Nearly a Century of Trying to Cure Cancer.
Neoplasms
Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids.
Neoplasms
Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers.
Neoplasms
Toponostics of invasive ductal breast carcinoma: combination of spatial protein expression imaging and quantitative proteome signature analysis.
Neoplasms
Transplacental effects of carcinogens and non-carcinogens on activities of pyruvate kinase and lactate dehydrogenase as well as isozymic pattern of LDH in mouse lung.
Neoplasms
TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma.
Neoplasms
TSP50 promotes the Warburg effect and hepatocyte proliferation via regulating PKM2 acetylation.
Neoplasms
TUM2-PK (pyruvate kinase type tumor M2), CA19-9 and CEA in patients with benign, malignant and metastasizing pancreatic lesions.
Neoplasms
Tumor antigens eliciting autoantibody response in cancer of gingivo-buccal complex.
Neoplasms
Tumor M2 pyruvate kinase as a stool marker for colorectal cancer: stability at room temperature and implications for application in the screening setting.
Neoplasms
Tumor M2 pyruvate kinase in diagnosis of nonsmall cell lung cancer: A meta-analysis based on Chinese population.
Neoplasms
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Neoplasms
Tumor M2 pyruvate kinase--determination in breast cancer patients receiving trastuzumab therapy.
Neoplasms
Tumor M2 pyruvate kinase: a tumor marker and its clinical application in gastrointestinal malignancy.
Neoplasms
Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells.
Neoplasms
Tumor M2-PK levels in haematological malignancies.
Neoplasms
Tumor M2-PK: A novel urine marker of bladder cancer.
Neoplasms
Tumor M2-pyruvate kinase and pancreatic cancer.
Neoplasms
Tumor M2-pyruvate kinase as tumor marker in exocrine pancreatic cancer a meta-analysis.
Neoplasms
Tumor M2-pyruvate kinase in lung cancer patients: immunohistochemical detection and disease monitoring.
Neoplasms
Tumor M2-pyruvate kinase in stool as a biomarker for diagnosis of colorectal cancer: A meta-analysis.
Neoplasms
Tumor M2-pyruvate kinase in the follow-up of inoperable lung cancer patients: a pilot study.
Neoplasms
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Neoplasms
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Neoplasms
Tumor M2-pyruvate kinase: a promising tumor marker in the diagnosis of gastro-intestinal cancer.
Neoplasms
Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy.
Neoplasms
Tumor markers in detection of lung cancer.
Neoplasms
Tumor pyruvate kinase isoenzyme type M2 and immunochemical fecal occult blood test: performance in screening for colorectal cancer.
Neoplasms
Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents.
Neoplasms
Tumor pyruvate kinase M2: A promising molecular target of gastrointestinal cancer.
Neoplasms
Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression.
Neoplasms
Tumor type M2 pyruvate kinase (TuM2-PK) as a novel plasma tumor marker in melanoma.
Neoplasms
Tumor type M2 pyruvate kinase expression in advanced breast cancer.
Neoplasms
Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls.
Neoplasms
Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma.
Neoplasms
Tumor type M2-pyruvate-kinase levels in pleural fluid versus plasma in cancer patients: a further tool to define the need for invasive procedures.
Neoplasms
Tumor-specific correlation of tumor M2 pyruvate kinase in pre-invasive, invasive and recurrent cervical cancer.
Neoplasms
Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells.
Neoplasms
Tumour M2-PK as a predictor of surgical outcome in ovarian cancer, a prospective cohort study.
Neoplasms
Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients.
Neoplasms
Tumour M2-pyruvate kinase: a gastrointestinal cancer marker.
Neoplasms
Turning on a Fuel Switch of Cancer: hnRNP Proteins Regulate Alternative Splicing of Pyruvate Kinase mRNA.
Neoplasms
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Neoplasms
Up-Regulation of PKM2 Relates to Retinal Ganglion Cell Apoptosis After Light-Induced Retinal Damage in Adult Rats.
Neoplasms
Using Pyruvate Kinase as a Predictor for Patient With Endometrial Cancer Having Complex Hyperplasia With Atypia to Prevent Hysterectomy and Preserve Fertility: Retrospective Immunohistochemical Study.
Neoplasms
Value of the serum levels of the tumor marker TUM2-PK in pancreatic cancer.
Neoplasms
Value of tumor M2 (Tu M2-PK) in patients with renal carcinoma.
Neoplasms
Value of tumor M2-PK in thyroid carcinoma: a pilot study.
Neoplasms
Verification of endometrial tissue biomarkers previously discovered using mass spectrometry-based proteomics by means of immunohistochemistry in a tissue microarray format.
Neoplasms
Versican expression level in cumulus cells is associated with human oocyte developmental competence.
Neoplasms
Vitamin K(3) and K(5) are inhibitors of tumor pyruvate kinase M2.
Neoplasms
Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells.
Neoplasms
WITHDRAWN: Regulation of Pyruvate Kinase M Switch towards PKM1 by LKB1-AMPK Axis Tolerates Hypoglycemic Stress in Cancer Cells.
Neoplasms
[Analysis of the statistical value of various commercially available stool tests - a comparison of one stool sample in correlation to colonoscopy]
Neoplasms
[Behavior of serum pyruvate kinase in neoplasms of the skeleton.]
Neoplasms
[Clinical significance of blood and fecal tumor M2-pyruvate kinase expression in patients with colorectal cancer].
Neoplasms
[Development of barcode and proteome profiling of glioblastoma].
Neoplasms
[Effects of stromal cells derived from the normal prostate on the glycolysis of prostate cancer cells].
Neoplasms
[Estrogen dependence of mammary gland tumors: the mechanisms of the disorder and the evaluation criteria]
Neoplasms
[Fecal Biomarker for Colorectal Cancer Diagnosis].
Neoplasms
[Hexokinase activity of erythrocytes in cancer patients]
Neoplasms
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
Neoplasms
[Immunohistologic photometric quantification of pyruvate kinase content of rat tumors]
Neoplasms
[Immunologic characterization of pyruvate kinase from Ehrlich-ascite tumor cells]
Neoplasms
[Intestinal cancer precautions. Stool test for tumor M2 pyruvate kinase]
Neoplasms
[M2-type pyruvate kinase in the diagnosis of hepatocarcinoma--a pilot study]
Neoplasms
[Metabolism enzyme controls cancer stemness].
Neoplasms
[Novel mechanism for invasion and metastasis involving metabolic enzymes in intractable cancer cells].
Neoplasms
[Pilot study on M2-PK-- a new non-invasive parameter for early diagnosis of colorectal carcinoma]
Neoplasms
[Properties of neoplasm pyruvate kinase]
Neoplasms
[Pyruvate kinase activity in the liver of rats with induced tumors]
Neoplasms
[The role of oncomarkers CEA, Cyfra-21, NSE, TU M2-PK in diagnosis and treatment of lung cancer]
Neoplasms
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
Neoplasms
[Tumor M2 pyruvate kinase in renal cell carcinoma. Studies of plasma in patients]
Neoplasms
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Neoplasms, Squamous Cell
Pyruvate kinase M2 is highly correlated with the differentiation and the prognosis of esophageal squamous cell cancer.
Nephritis
The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma.
Nephritis
Value of tumor M2 (Tu M2-PK) in patients with renal carcinoma.
Neuroacanthocytosis
A basis of the acanthocytosis in inherited and acquired disorders.
Neuroblastoma
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Neuroblastoma
Effect of oxygen and glucose availability on the glycolytic rate in neuroblastoma cells under different conditions of culture.
Neuroblastoma
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Neuroblastoma
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction.
Neuroblastoma
Pyruvate kinase isozymes in neurons, glia, neuroblastoma, and glioblastoma.
Neuroblastoma
Severe H1N1-associated acute respiratory failure in immunocompromised children.
Neuroblastoma
[Effects of plasminogen, streptokinase and their equimolar complexes with pyruvate kinase on the human neuroblastoma IMR-32 cells]
Neurodegenerative Diseases
Amyloid-? peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex.
Neuroectodermal Tumors
Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
Neuroendocrine Tumors
Diagnostic value of tumor M2-pyruvate kinase in neuroendocrine tumors. A comparative study with chromogranin A.
Neuroendocrine Tumors
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Neuromuscular Diseases
Pyruvate kinase: diagnostic value in neuromuscular disease.
Neuromuscular Diseases
Serum pyruvate kinase in different neuromuscular diseases and in carriers of muscular dystrophy.
Neuromuscular Diseases
The importance of serum pyruvate kinase in neuromuscular diseases and carrier states.
Neuromuscular Diseases
[Serum pyruvate kinase (PK) in the diagnosis of neuromuscular diseases]
Non-alcoholic Fatty Liver Disease
Berberine reverses abnormal expression of L-type pyruvate kinase by DNA demethylation and histone acetylation in the livers of the non-alcoholic fatty disease rat.
Non-alcoholic Fatty Liver Disease
Liver Pyruvate Kinase Promotes NAFLD/NASH in both Mice and Humans in a Sex-Specific Manner.
Non-alcoholic Fatty Liver Disease
Network analyses identify liver-specific targets for treating liver diseases.
Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease and Gastric Bypass Surgery Regulate Serum And Hepatic Levels of Pyruvate Kinase Isoenzyme M2.
Non-alcoholic Fatty Liver Disease
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Odontogenic Cysts
Increased M2 Isoform of Pyruvate Kinase in Fibroblasts Contributes to the Growth, Aggressiveness, and Osteoclastogenesis of Odontogenic Keratocysts.
Optic Atrophy, Autosomal Dominant
Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure.
Osteoarthritis
Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis.
Osteoarthritis
SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1? and contributes to LIPUS-mediated anti-inflammatory effect.
Osteosarcoma
Knockdown of pyruvate kinase type M2 suppresses tumor survival and invasion in osteosarcoma cells both in vitro and in vivo.
Osteosarcoma
Overexpression of pyruvate kinase M2 predicts a poor prognosis for patients with osteosarcoma.
Osteosarcoma
TRIM58 Interacts with Pyruvate Kinase M2 to Inhibit Tumorigenicity in Human Osteosarcoma Cells.
Osteosclerosis
Erythrocytic Pyruvate Kinase Mutations Causing Hemolytic Anemia, Osteosclerosis, and Secondary Hemochromatosis in Dogs.
Osteosclerosis
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
Ovarian Diseases
M2-PK as a novel marker in ovarian cancer. A prospective cohort study.
Ovarian Neoplasms
AKT2 contributes to increase ovarian cancer cell migration and invasion through the AKT2-PKM2-STAT3/NF-?B axis.
Ovarian Neoplasms
Correlation of Pyruvate Kinase M2 Expression with Clinicopathological Data in Ovarian Cancer.
Ovarian Neoplasms
Down-regulation of Ras-related protein Rab 5C-dependent endocytosis and glycolysis in cisplatin-resistant ovarian cancer cell lines.
Ovarian Neoplasms
Follicle-stimulating hormone promoted pyruvate kinase isozyme type M2-induced glycolysis and proliferation of ovarian cancer cells.
Ovarian Neoplasms
Ginsenoside 20(S)?Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells.
Ovarian Neoplasms
iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer.
Ovarian Neoplasms
M2-PK as a novel marker in ovarian cancer. A prospective cohort study.
Ovarian Neoplasms
Metabolic markers GAPDH, PKM2, ATP5B and BEC-index in advanced serous ovarian cancer.
Ovarian Neoplasms
MiR-338-3p targets pyruvate kinase M2 and affects cell proliferation and metabolism of ovarian cancer.
Ovarian Neoplasms
Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.
Ovarian Neoplasms
Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer.
Ovarian Neoplasms
Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway in Ovarian Cancer Cells.
Ovarian Neoplasms
Tumour M2-PK as a predictor of surgical outcome in ovarian cancer, a prospective cohort study.
Pain Insensitivity, Congenital
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
Pancreatic Neoplasms
Analysis of in vivo Interaction between RNA Binding Proteins and Their RNA Targets by UV Cross-linking and Immunoprecipitation (CLIP) Method.
Pancreatic Neoplasms
Characterization of glycoproteins in pancreatic cyst fluid using a high-performance multiple lectin affinity chromatography platform.
Pancreatic Neoplasms
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Pancreatic Neoplasms
Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells.
Pancreatic Neoplasms
Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer.
Pancreatic Neoplasms
In vivo factors influencing tumour M2-pyruvate kinase level in human pancreatic cancer cell lines.
Pancreatic Neoplasms
Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using subtractive hybridization.
Pancreatic Neoplasms
Mass spectrometric analysis reveals O-methylation of pyruvate kinase from pancreatic cancer cells.
Pancreatic Neoplasms
MIR210HG regulates glycolysis, cell proliferation, and metastasis of pancreatic cancer cells through miR-125b-5p/HK2/PKM2 axis.
Pancreatic Neoplasms
Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells.
Pancreatic Neoplasms
Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells.
Pancreatic Neoplasms
Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome.
Pancreatic Neoplasms
RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion.
Pancreatic Neoplasms
Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer.
Pancreatic Neoplasms
The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
Pancreatic Neoplasms
TUM2-PK (pyruvate kinase type tumor M2), CA19-9 and CEA in patients with benign, malignant and metastasizing pancreatic lesions.
Pancreatic Neoplasms
Tumor M2-pyruvate kinase and pancreatic cancer.
Pancreatic Neoplasms
Tumor M2-pyruvate kinase as tumor marker in exocrine pancreatic cancer a meta-analysis.
Pancreatic Neoplasms
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Pancreatic Neoplasms
Tumor marker M2-pyruvate-kinase in differential diagnosis of chronic pancreatitis and pancreatic cancer.
Pancreatic Neoplasms
Tumour M2-pyruvate kinase: a gastrointestinal cancer marker.
Pancreatic Neoplasms
Upregulation of pyruvate kinase M2 expression by fatty acid synthase contributes to gemcitabine resistance in pancreatic cancer.
Pancreatic Neoplasms
Value of the serum levels of the tumor marker TUM2-PK in pancreatic cancer.
Pancreatitis, Chronic
Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia.
Pancreatitis, Chronic
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Pancreatitis, Chronic
Tumor marker M2-pyruvate-kinase in differential diagnosis of chronic pancreatitis and pancreatic cancer.
Pancytopenia
[Decrease of erythrocyte pyruvate kinase activity and foetal haemoglobin rising in pancytopenia (author's transl)]
Papilloma
Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex.
Parasitemia
Estimating the degree of infection of Plasmodium berghei infected red blood cells by evaluation of pyruvate kinase activity.
Parasitemia
Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J.
Parkinson Disease
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Parkinson Disease
Increased Striatal mRNA and Protein Levels of the Immunophilin FKBP-12 in Experimental Parkinson's Disease and Identification of FKBP-12-Binding Proteins.
Parvoviridae Infections
Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency.
Periodontal Diseases
Pyruvate Kinase, Inflammation and Periodontal Disease.
Persistent Infection
Chlamydophila (Chlamydia) pneumoniae infection of human astrocytes and microglia in culture displays an active, rather than a persistent, phenotype.
Phenylketonurias
Alanine prevents the in vitro inhibition of glycolysis caused by phenylalanine in brain cortex of rats.
Phenylketonurias
Combined phenylketonuria and pyruvate kinase deficiency. A case report.
Phenylketonurias
Phenylketonuria, pyruvate kinase deficiency and Kouska'a fallacy.
Phenylketonurias
Phenylketonuria: phenylalanine inhibits brain pyruvate kinase in vivo.
Pheochromocytoma
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction.
phosphoglycerate kinase deficiency
Glucose phosphate isomerase (GPI) Tadikonda: Characterization of a novel Pro340Ser mutation.
Pleural Effusion
Tumor type M2-pyruvate-kinase levels in pleural fluid versus plasma in cancer patients: a further tool to define the need for invasive procedures.
Polycythemia
Hereditary pyruvate kinase abnormalities associated with erythrocytosis.
Polycythemia
[Pyruvate kinase, 2,3 bisphosphoglycerate and fibrin-fibrinogen degradation products in patients with polycythemia, before and after erythrapheresis therapy]
Polycythemia Vera
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Potassium Deficiency
[Metabolic abnormality in erthyrocytes with atypical pyruvate kinase and potassium deficiency]
Pouchitis
Fecal pyruvate kinase (M2-PK): a new predictor for inflammation and severity of pouchitis.
Pre-Eclampsia
Leukocyte pyruvate kinase expression is reduced in normal human pregnancy but not in pre-eclampsia.
Pre-Eclampsia
Pyruvate kinase deficiency complicating pregnancy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Severe H1N1-associated acute respiratory failure in immunocompromised children.
Preleukemia
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Primary Myelofibrosis
Atypical intraerythrocytic pyruvate kinase in some haematological diseases.
Primary Myelofibrosis
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
Prostatic Hyperplasia
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Prostatic Neoplasms
PKM2 and HIF-1? regulation in prostate cancer cell lines.
Prostatic Neoplasms
Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis.
Prostatic Neoplasms
Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling.
Prostatic Neoplasms
Pyruvate kinase type tumor M2 in urological malignancies.
Prostatic Neoplasms
Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.
Prostatic Neoplasms
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Prostatic Neoplasms
[Silencing pyruvate kinase M2 sensitizes human prostate cancer PC3 cells to gambogic acid-induced apoptosis].
Protein-Energy Malnutrition
[Erythrocyte enzyme activity (glucose-6-phosphate dehydrogenase, pyruvate kinase, catalase) in 13 cases of protein-calorie malnutrition in infants]
Proteinuria
Pre-analytical problems in the measurement of tumor type pyruvate kinase (tumor M2-PK).
Psoriasis
Granulocyte pyruvate kinase in psoriasis vulgaris and psoriasis arthropathica.
Psoriasis
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
Psoriasis
[Pyruvate kinase activity in the granulocytes of patients with psoriasis]
Pulmonary Arterial Hypertension
Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
Pulmonary Arterial Hypertension
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Pulmonary Arterial Hypertension
Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.
Pulmonary Atelectasis
Superoxide dismutase and cytochrome oxidase in collapsed lungs: possible role in reexpansion edema.
Pulmonary Disease, Chronic Obstructive
Organization of metabolic pathways in vastus lateralis of patients with chronic obstructive pulmonary disease.
pyruvate kinase deficiency
2,3-Diphosphoglycerate and 3-phosphoglycerate in red cell pyruvate kinase deficiency.
pyruvate kinase deficiency
A CASE OF CONGENITAL ATYPICAL HAEMOLYTIC ANAEMIA WITH PYRUVATE KINASE DEFICIENCY.
pyruvate kinase deficiency
A case of congenital red cell pyruvate kinase deficiency associated with hereditary stomatocytosis.
pyruvate kinase deficiency
A case of haemolytic anaemia due to pyruvate kinase deficiency.
pyruvate kinase deficiency
A case of severe pyruvate kinase deficiency in a primigravida: successful outcome.
pyruvate kinase deficiency
A Case With Pyruvate Kinase Deficiency Remarkably Sensitive to Heat.
pyruvate kinase deficiency
A combined system for the study of glutathione metabolism in erythrocytes.
pyruvate kinase deficiency
A Family Affected by a Life-Threatening Erythrocyte Defect Caused by Pyruvate Kinase Deficiency With Normal Iron Status: A Case Report.
pyruvate kinase deficiency
A kindred with red cell pyruvate kinase deficiency.
pyruvate kinase deficiency
A low Km phosphoenolpyruvate mutant in the Amish with red cell pyruvate kinase deficiency.
pyruvate kinase deficiency
A modified screening procedure to detect pyruvate kinase deficiency.
pyruvate kinase deficiency
A monomeric form of pyruvate kinase in human pyruvate kinase deficiency.
pyruvate kinase deficiency
A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency.
pyruvate kinase deficiency
A new sickle cell disease phenotype associating Hb S trait, severe pyruvate kinase deficiency (PK Conakry), and an alpha2 globin gene variant (Hb Conakry).
pyruvate kinase deficiency
A new variant of erythrocyte pyruvate kinase - PK "maebashi".
pyruvate kinase deficiency
A New Variant of PKLR Gene Associated With Mild Hemolysis may be Responsible for the Misdiagnosis in Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
A new variant of red blood cell pyruvate kinase deficiency.
pyruvate kinase deficiency
A Novel and a Previously Described Compound Heterozygous PKLR Gene Mutations Causing Pyruvate Kinase Deficiency in a Chinese Child.
pyruvate kinase deficiency
A novel mutation causing pyruvate kinase deficiency responsible for a severe neonatal respiratory distress syndrome and jaundice.
pyruvate kinase deficiency
A novel PKLR gene mutation identified using advanced molecular techniques.
pyruvate kinase deficiency
A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
A pyruvate kinase deficiency child with novel PK-LR gene mutations was successfully cured by matched unrelated donor peripheral blood stem cell transplantation.
pyruvate kinase deficiency
A rare combination of two inherited disorders in one patient: pyruvate kinase deficiency and hemochromatosis.
pyruvate kinase deficiency
A SCREENING METHOD FOR THE DETECTION OF ERYTHROCYTE PYRUVATE KINASE DEFICIENCY.
pyruvate kinase deficiency
A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.
pyruvate kinase deficiency
A Spanish family with erythrocyte pyruvate kinase deficiency: contribution of various immunologic methods in the study of the mutant enzyme.
pyruvate kinase deficiency
A Sri Lankan girl with a new genetic variant in the PKLR gene causing pyruvate kinase deficiency: a case report.
pyruvate kinase deficiency
Acquired hemolytic anemia associated with infectious mononucleosis in a patient with congenital pyruvate kinase deficiency.
pyruvate kinase deficiency
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
pyruvate kinase deficiency
Acquired pyruvate kinase deficiency.
pyruvate kinase deficiency
Acquired pyruvate kinase deficiency. The effect of maleic acid upon human erythrocyte pyruvate kinase.
pyruvate kinase deficiency
Acquired red cell pyruvate kinase deficiency in acute leukemias.
pyruvate kinase deficiency
Acquired red cell pyruvate kinase deficiency in leukemias and related disorders.
pyruvate kinase deficiency
Addressing the diagnostic gaps in pyruvate kinase deficiency: Consensus recommendations on the diagnosis of pyruvate kinase deficiency.
pyruvate kinase deficiency
Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparum in vitro.
pyruvate kinase deficiency
Adoptive immunotherapy to increase the level of donor hematopoietic chimerism after nonmyeloablative marrow transplantation for severe canine hereditary hemolytic anemia.
pyruvate kinase deficiency
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
pyruvate kinase deficiency
Alcohol-associated haemolysis in Zieve's syndrome: a clinical and laboratory study of five cases.
pyruvate kinase deficiency
Allogeneic hematopoietic stem cell transplantation in a 3-year-old boy with congenital pyruvate kinase deficiency: A case report.
pyruvate kinase deficiency
Alu element insertion in PKLR gene as a novel cause of pyruvate kinase deficiency in Middle Eastern patients.
pyruvate kinase deficiency
An autopsy case of pyruvate kinase deficiency anemia associated with severe hemochromatosis.
pyruvate kinase deficiency
Analysis of malaria associated genetic traits in Cabo Verde, a melting pot of European and sub Saharan settlers.
pyruvate kinase deficiency
Analysis of pyruvate kinase-deficiency mutations that produce nonspherocytic hemolytic anemia.
pyruvate kinase deficiency
Anesthesia management for ENT surgery in a child with X-linked pyruvate kinase deficiency.
pyruvate kinase deficiency
Animal model of human disease: pyruvate kinase deficiency.
pyruvate kinase deficiency
Anomalous pyruvate kinase deficiency in the Basenji dog.
pyruvate kinase deficiency
Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency.
pyruvate kinase deficiency
Appraisal of patient-reported outcome measures in analogous diseases and recommendations for use in phase II and III clinical trials of pyruvate kinase deficiency.
pyruvate kinase deficiency
Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE).
pyruvate kinase deficiency
Babesia rodhaini: the protective effect of pyruvate kinase deficiency in mice.
pyruvate kinase deficiency
Bilirubin cholelithiasis and haemosiderosis in an anaemic pyruvate kinase-deficient Somali cat.
pyruvate kinase deficiency
Biochemical and molecular characterization of variant pyruvate kinase enzymes and genes from three patients with red blood cell pyruvate kinase deficiency.
pyruvate kinase deficiency
Biochemical characterization of three mutant isozymes of erythrocyte pyruvate kinase: PK-"Gainesville," PK-"San Juan," and PK-"Cape Canaveral".
pyruvate kinase deficiency
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
pyruvate kinase deficiency
Calculation of surface area and volume of human erythrocytes from scanning electron micrographs.
pyruvate kinase deficiency
Canine erythrocyte pyruvate kinase. I. Properties of the normal enzyme.
pyruvate kinase deficiency
Canine erythrocyte pyruvate kinase. II. Properties of abnormal enzyme associated with hemolytic anemia in the Basenji dog.
pyruvate kinase deficiency
Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review.
pyruvate kinase deficiency
Case report: pyruvate kinase deficiency.
pyruvate kinase deficiency
Characterization of the severe phenotype of pyruvate kinase deficiency.
pyruvate kinase deficiency
Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
Chronic haemolytic anaemia in two patients heterozygous for erythrocyte pyruvate kinase deficiency. Electrofocusing and immunological studies of erythrocyte and liver pyruvate kinase.
pyruvate kinase deficiency
Chronic myelomonocytic leukemia associated with hereditary pyruvate kinase deficiency and multiple acquired erythrocyte abnormalities.
pyruvate kinase deficiency
Clinical and Molecular Spectrum of Glucose-6-Phosphate Isomerase Deficiency. Report of 12 New Cases.
pyruvate kinase deficiency
Clinical course of pyruvate kinase deficiency in Abyssinian and Somali cats.
pyruvate kinase deficiency
Clinical heterogeneity of erythrocyte pyruvate kinase deficiency. Evidence of an impaired utilization of ATP in a clinically severe form.
pyruvate kinase deficiency
Clinically relevant gene editing in hematopoietic stem cells for the treatment of pyruvate kinase deficiency.
pyruvate kinase deficiency
Coexistence of alpha-thalassemia and a new pyruvate kinase variant: PK Fukien.
pyruvate kinase deficiency
Coexistence of congenital red cell pyruvate kinase and band 3 deficiency.
pyruvate kinase deficiency
Combined phenylketonuria and pyruvate kinase deficiency. A case report.
pyruvate kinase deficiency
Comorbidities and complications in adults with pyruvate kinase deficiency.
pyruvate kinase deficiency
Compound heterozygosity in PKLR gene for a previously unrecognized intronic polymorphism and a rare missense mutation as a novel cause of severe pyruvate kinase deficiency.
pyruvate kinase deficiency
Concise review: pyruvate kinase deficiency: historical perspective and recent progress of molecular genetics.
pyruvate kinase deficiency
Concomitant laparoscopic splenectomy and cholecystectomy as an effective and minimally invasive treatment of pyruvate kinase deficiency with gallstones.
pyruvate kinase deficiency
Congenital dyserythropoietic anemia associated to a GATA1 mutation aggravated by pyruvate kinase deficiency.
pyruvate kinase deficiency
Congenital hemolytic anemia in the Basenji dog due to erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Congenital Hemolytic Anemias: Is There a Role for the Immune System?
pyruvate kinase deficiency
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
pyruvate kinase deficiency
Congenital non-spherocytic haemolytic anaemia variants with primary and secondary pyruvate kinase deficiency. I. Erythrokinetic patterns.
pyruvate kinase deficiency
Congenital non-spherocytic haemolytic anaemia variants with primary and secondary pyruvate kinase deficiency. II. Enzymatic studies.
pyruvate kinase deficiency
Consensus document for the diagnosis and treatment of pyruvate kinase deficiency.
pyruvate kinase deficiency
Consequences at mRNA level of the PKLR gene splicing mutations IVS10(+1)G-->C and IVS8(+2)T-->G causing pyruvate kinase deficiency.
pyruvate kinase deficiency
Cord blood transplantation in a young child with pyruvate kinase deficiency.
pyruvate kinase deficiency
Correction to: Clinical approach to neurodegenerative disorders in childhood: an updated overview.
pyruvate kinase deficiency
Correction: Stem Cell Selection In Vivo Using Foamy Vectors Cures Canine Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
Deferasirox in pyruvate kinase deficiency.
pyruvate kinase deficiency
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia.
pyruvate kinase deficiency
Detection of G6PD and pyruvate kinase deficiencies in reticulocytosis by reference to erythrocyte creatine.
pyruvate kinase deficiency
Determination of erythrocyte pyruvate kinase deficiency in Basenjis with chronic hemolytic anemia.
pyruvate kinase deficiency
Development of the pyruvate kinase deficiency diary and pyruvate kinase deficiency impact assessment: Disease-specific assessments.
pyruvate kinase deficiency
Diagnosis of pyruvate kinase deficiency in a transfusion-dependent patient with severe hemolytic anemia.
pyruvate kinase deficiency
Diagnosis of Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
Disruption of a novel regulatory element in the erythroid-specific promoter of the human PKLR gene causes severe pyruvate kinase deficiency.
pyruvate kinase deficiency
Dyserythropoiesis in a child with pyruvate kinase deficiency and coexistent unilateral multicystic dysplastic kidney.
pyruvate kinase deficiency
Effect of riboflavin treatment on human red cell pyruvate kinase deficiency.
pyruvate kinase deficiency
Electrophoretic demonstration of heterozygosis in hereditary pyruvate kinase deficiency. An unusual method.
pyruvate kinase deficiency
Electrophoretic, immunologic and kinetic characterization of erythrocyte pyruvate kinase in the Basenji dog with pyruvate kinase deficiency.
pyruvate kinase deficiency
Enzymatic pattern of glucose metabolic pathways in pyruvate kinase-deficient erythrocytes.
pyruvate kinase deficiency
Equine infectious anemia. Pyruvate kinase deficiency in the red cells of thoroughbred horses.
pyruvate kinase deficiency
Erythrocytapheresis as a novel treatment option for adult patients with pyruvate kinase deficiency.
pyruvate kinase deficiency
Erythrocyte enzyme deficiencies. Pyruvate kinase deficiency.
pyruvate kinase deficiency
Erythrocyte fructose 2,6-bisphosphate content in congenital hemolytic anemias.
pyruvate kinase deficiency
Erythrocyte PK deficiency: biochemical characterization of a patient with haemolytic anemia.
pyruvate kinase deficiency
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. I. Cell morphology.
pyruvate kinase deficiency
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. II. Cell deformability.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency associated with kinetically aberrant isozyme.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency in a beagle dog.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency in an old-order Amish cohort: Longitudinal risk and disease management.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency in newborns of eastern Saudi Arabia.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency in non-spherocytic hemolytic anemia: a system of multiple genetic markers?
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency in the Ohio Amish: origin and characterization of the mutant enzyme.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency in three West Highland white terriers in Ireland and the UK.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency mutation identified in multiple breeds of domestic cats.
pyruvate kinase deficiency
ERYTHROCYTE PYRUVATE KINASE DEFICIENCY RESULTING IN CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency. A kinetic study of the membrane-localised and cytoplasmatic enzyme from six patients.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency. The influence of physiologically important metabolites on the function of normal and defective enzymes.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency: 11 new cases.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency: 2015 status report.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency: a kinetic method for differentiation between heterozygosity and compound-heterozygosity.
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency: characterization of a new variant (PK "Aarau").
pyruvate kinase deficiency
Erythrocyte pyruvate kinase deficiency: relations of residual enzyme activity, altered regulation of defective enzymes and concentrations of high-energy phosphates with the severity of clinical manifestation.
pyruvate kinase deficiency
Erythrocytic pyruvate kinase deficiency and AB blood types in Australian Abyssinian and Somali cats.
pyruvate kinase deficiency
Erythrocytic pyruvate kinase deficiency and hemolytic anemia inherited as a dominant trait.
pyruvate kinase deficiency
Erythropoiesis: Pyruvate Kinase Deficiency which Causes Nonspherocytic Hemolytic Anemia: The Gene and its Mutations.
pyruvate kinase deficiency
Erythropoietin in the treatment of iron overload in a patient with hemolytic anemia and pyruvate kinase deficiency.
pyruvate kinase deficiency
Estimating the prevalence of pyruvate kinase deficiency from the gene frequency in the general white population.
pyruvate kinase deficiency
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
pyruvate kinase deficiency
Ex vivo analysis of aberrant splicing induced by two donor site mutations in PKLR of a patient with severe pyruvate kinase deficiency.
pyruvate kinase deficiency
Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications.
pyruvate kinase deficiency
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria.
pyruvate kinase deficiency
EXTREME HEMOLYSIS AND RED-CELL DISTORTION IN ERYTHROCYTE PYRUVATE KINASE DEFICIENCY. I. MORPHOLOGY, ERYTHROKINETICS AND FAMILY ENZYME STUDIES.
pyruvate kinase deficiency
EXTREME HEMOLYSIS AND RED-CELL DISTORTION IN ERYTHROCYTE PYRUVATE KINASE DEFICIENCY. II. MEASUREMENTS OF ERYTHROCYTE GLUCOSE CONSUMPTION, POTASSIUM FLUX AND ADENOSINE TRIPHOSPHATE STABILITY.
pyruvate kinase deficiency
Failure of partial splenectomy to ameliorate the anemia of pyruvate kinase deficiency.
pyruvate kinase deficiency
Familial haemolytic anaemia due to pyruvate kinase deficiency.
pyruvate kinase deficiency
Fetal anaemia due to pyruvate kinase deficiency.
pyruvate kinase deficiency
First reported case of prenatal diagnosis for pyruvate kinase deficiency in a Chinese family.
pyruvate kinase deficiency
First-trimester prenatal diagnosis of pyruvate kinase deficiency in an Indian family with the pyruvate kinase-Amish mutation.
pyruvate kinase deficiency
Fragility of abnormal erythrocytes evaluated by response to shear stress.
pyruvate kinase deficiency
Frame shift mutation, exon skipping, and a two-codon deletion caused by splice site mutations account for pyruvate kinase deficiency.
pyruvate kinase deficiency
Frequency of erythrocyte pyruvate kinase deficiency in Chinese infants.
pyruvate kinase deficiency
Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA.
pyruvate kinase deficiency
Gene symbol: PKLR. Disease: Pyruvate kinase deficiency.
pyruvate kinase deficiency
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
pyruvate kinase deficiency
Genetic control of resistance to human malaria.
pyruvate kinase deficiency
Genetic test for pyruvate kinase deficiency of Basenjis.
pyruvate kinase deficiency
Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency.
pyruvate kinase deficiency
Glucose-6-phosphate dehydrogenase and red cell pyruvate kinase deficiency in neonatal jaundice cases in egypt.
pyruvate kinase deficiency
Glycolate kinase activity in human red cells.
pyruvate kinase deficiency
Haemolysis due to pyruvate kinase deficiency and other glycolytic enzymopathies.
pyruvate kinase deficiency
Haemolytic anaemia due to pyruvate kinase deficiency.
pyruvate kinase deficiency
Health-Related Quality of Life and Fatigue in Children and Adults with Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
pyruvate kinase deficiency
Hemochromatosis and pyruvate kinase deficiency. Report of a case and review of the literature.
pyruvate kinase deficiency
Hemolytic anemia and pyruvate kinase deficiency in pregnancy.
pyruvate kinase deficiency
Hemolytic anemia due to pyruvate kinase deficiency: characterization of the enzymatic activity from eight patients.
pyruvate kinase deficiency
Hemolytic anemia in pregnancy associated with erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma.
pyruvate kinase deficiency
Hepatosplenomegaly as the only prenatal finding in a fetus with pyruvate kinase deficiency anemia.
pyruvate kinase deficiency
Hepcidin and Anemia: A Tight Relationship.
pyruvate kinase deficiency
Hereditary disorders of enzymes in the Embden-Meyerhof pathway of glycolysis.
pyruvate kinase deficiency
Hereditary disorders of red cell enzymes in the Embden-Meyerhof pathway.
pyruvate kinase deficiency
Hereditary erythrocyte pyruvate kinase deficiency: molecular and functional studies of four mutant PK variants detected in Spain.
pyruvate kinase deficiency
Hereditary nonspherocytic hemolytic anemia due to pyruvate kinase deficiency: a prevalence study in Quebec (Canada).
pyruvate kinase deficiency
Hereditary pyruvate kinase deficiency: role of the abnormal enzyme in red cell pathophysiology.
pyruvate kinase deficiency
Hereditary Xerocytosis due to Mutations in PIEZO1 Gene Associated with Heterozygous Pyruvate Kinase Deficiency and Beta-Thalassemia Trait in Two Unrelated Families.
pyruvate kinase deficiency
Heterogeneity of erythrocyte pyruvate kinase deficiency and related metabolic disorders in patients with hematological diseases.
pyruvate kinase deficiency
Heterozygous pyruvate kinase deficiency and severe hemolytic anemia in a pregnant woman with concomitant, glucose-6-phosphate dehydrogenase deficiency.
pyruvate kinase deficiency
Homozygous pyruvate kinase deficiency in Hong Kong ethnic minorities.
pyruvate kinase deficiency
How I do in front of an hemolytic anemia of unknown etiology?
pyruvate kinase deficiency
How we manage patients with pyruvate kinase deficiency.
pyruvate kinase deficiency
Human erythrocyte pyruvate kinase deficiency: the use of a kinetic study of mutant enzymes for the detection of heterozygotes.
pyruvate kinase deficiency
Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia.
pyruvate kinase deficiency
Human red blood cell polymorphisms and malaria.
pyruvate kinase deficiency
Hydrops fetalis associated with erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
pyruvate kinase deficiency
Identification and in silico characterization of a novel PKLR genotype in a Turkish newborn.
pyruvate kinase deficiency
Identification of a 6 base pair insertion in West Highland White Terriers with erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Idiopathic pulmonary arterial hypertension in a patient with pyruvate kinase deficiency and paravertebral extramedullary hematopoiesis.
pyruvate kinase deficiency
Impaired erythrocyte phosphoribosylpyrophosphate formation in hemolytic anemia due to pyruvate kinase deficiency.
pyruvate kinase deficiency
Improving the laboratory diagnosis of pyruvate kinase deficiency.
pyruvate kinase deficiency
In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach.
pyruvate kinase deficiency
Increased adsorption of cytoplasmic proteins to the erythrocyte membrane in ATP-depleted normal and pyruvate kinase-deficient mature cells and reticulocytes.
pyruvate kinase deficiency
Increased erythrocyte deformability in fetal erythropoiesis and in erythrocytes deficient in glucose-6-phosphate dehydrogenase and other glycolytic enzymes.
pyruvate kinase deficiency
Increased IgG molecules bound to the surface of red blood cells of patients with sickle cell anemia.
pyruvate kinase deficiency
Ineffective erythropoiesis in the spleen of a patient with pyruvate kinase deficiency.
pyruvate kinase deficiency
Influence of the rebox state of glutathione upon pyruvate kinase in the intact erythrocyte.
pyruvate kinase deficiency
Inherited erythrocyte pyruvate kinase deficiency in a beagle dog.
pyruvate kinase deficiency
Inherited erythrocyte pyruvate kinase deficiency: Studies on 15 members of two related families.
pyruvate kinase deficiency
Inherited pyruvate kinase deficiency and normal haematologic values in Australian Basenji dogs.
pyruvate kinase deficiency
Inhibition of erythrocyte glycolysis associated with tranylcypromine (MAOinhibitor) administration in rabbits: pyruvate kinase deficiency.
pyruvate kinase deficiency
Inhibition of the pentose phosphate shunt by 2,3-diphosphoglycerate in erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
pyruvate kinase deficiency
Investigations of the kinetics of red cell pyruvate kinase in normal individuals and in a patient with pyruvate kinase deficiency.
pyruvate kinase deficiency
In Vitro and In Vivo Genetic Disease Modeling via NHEJ-Precise Deletions Using CRISPR-Cas9.
pyruvate kinase deficiency
Iron overload associated with congenital pyruvate kinase deficiency and high dose ascorbic acid ingestion.
pyruvate kinase deficiency
Iron overload in congenital erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Iron status and HFE genotype in erythrocyte pyruvate kinase deficiency: study of Italian cases.
pyruvate kinase deficiency
Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in the PKLR gene (p.Arg518fs), and low hepcidin to ferritin ratios.
pyruvate kinase deficiency
Iron status in red cell pyruvate kinase deficiency: study of Italian cases.
pyruvate kinase deficiency
Ischaemic stroke complicating pyruvate kinase deficiency.
pyruvate kinase deficiency
Kinetic properties of mutant enzymes in erythrocyte phosphofructokinase deficiency and erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Laboratory approach to investigation of anemia with a focus on pyruvate kinase deficiency.
pyruvate kinase deficiency
Laboratory studies of erythrocytic pyruvate kinase deficiency. Pathogenesis of the hemolysis.
pyruvate kinase deficiency
Large animal models for foamy virus vector gene therapy.
pyruvate kinase deficiency
Lemierre Syndrome in a Patient With Splenectomy Secondary to Pyruvate Kinase Deficiency, Complicated by Heparin Resistance.
pyruvate kinase deficiency
Life-span and organ sequestration of the red cells in pyruvate kinase deficiency.
pyruvate kinase deficiency
Liver cirrhosis as a consequence of iron overload caused by hereditary nonspherocytic hemolytic anemia.
pyruvate kinase deficiency
Long-term survival and reversal of iron overload after marrow transplantation in dogs with congenital hemolytic anemia.
pyruvate kinase deficiency
Malaria: looking for selection signatures in the human PKLR gene region.
pyruvate kinase deficiency
Management of pyruvate kinase deficiency in children and adults.
pyruvate kinase deficiency
Mathematical modelling of metabolic pathways affected by an enzyme deficiency. A mathematical model of glycolysis in normal and pyruvate-kinase-deficient red blood cells.
pyruvate kinase deficiency
Membrane-localized pyruvate kinase of red blood cells in hemolytic anemia associated with pyruvate kinase deficiency.
pyruvate kinase deficiency
Mitral Valve Replacement With Cardiopulmonary Bypass in a Patient With Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
Modulating erythrocyte chimerism in a mouse model of pyruvate kinase deficiency.
pyruvate kinase deficiency
Molecular abnormality of erythrocyte pyruvate kinase deficiency in the Amish.
pyruvate kinase deficiency
Molecular alterations in congenital erythrocyte pyruvate kinase deficiencies.
pyruvate kinase deficiency
Molecular Analyses of Pyruvate Kinase Deficient Turkish Patients from a Single Center.
pyruvate kinase deficiency
Molecular and clinical heterogeneity in pyruvate kinase deficiency in India.
pyruvate kinase deficiency
Molecular aspects of erythroenzymopathies associated with hereditary hemolytic anemia.
pyruvate kinase deficiency
Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in the PKLR gene.
pyruvate kinase deficiency
Molecular characterization of the PK-LR gene in pyruvate kinase deficient Spanish patients. Red Cell Pathology Group of the Spanish Society of Haematology (AEHH).
pyruvate kinase deficiency
Molecular characterization of the PK-LR gene in sixteen pyruvate kinase-deficient patients.
pyruvate kinase deficiency
Molecular genetic testing enabled the diagnosis of otherwise undiagnosable cases of pyruvate kinase deficiency.
pyruvate kinase deficiency
Molecular heterogeneity of pyruvate kinase deficiency.
pyruvate kinase deficiency
Molecular mechanism of erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Moya moya syndrome in a child with pyruvate kinase deficiency and combined prothrombotic factors.
pyruvate kinase deficiency
Multiple exchange transfusions in the treatment of a newborn with pyruvate kinase deficiency.
pyruvate kinase deficiency
Muscle pyruvate kinase deficiency: glycogen storage disease or mitochondrial myopathy?
pyruvate kinase deficiency
Mutations in the R-type pyruvate kinase gene and altered enzyme kinetic properties in patients with hemolytic anemia due to pyruvate kinase deficiency.
pyruvate kinase deficiency
Myelodysplastic syndrome in a patient with hereditary pyruvate kinase deficiency.
pyruvate kinase deficiency
Neonatal hemolysis due to a transient severity of inherited pyruvate kinase deficiency.
pyruvate kinase deficiency
Neonatal hyperbilirubinemia caused by pyruvate kinase deficiency.
pyruvate kinase deficiency
Neutrophil pyruvate kinase deficiency with recurrent staphylococcal infections: first reported case.
pyruvate kinase deficiency
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
pyruvate kinase deficiency
Next-Generation Sequencing-Based Diagnosis of Unexplained Inherited Hemolytic Anemias Reveals Wide Genetic and Phenotypic Heterogeneity.
pyruvate kinase deficiency
Nonspherocytic haemolytic anaemia and severe jaundice in a newborn with partial pyruvate kinase deficiency.
pyruvate kinase deficiency
Normalisation of red blood cell pyruvate kinase in pyruvate kinase deficiency by riboflavin treatment.
pyruvate kinase deficiency
Novel human pathological mutations. Gene symbol: PKLR. Disease: pyruvate kinase deficiency.
pyruvate kinase deficiency
Novel mutations and structural implications in R-type pyruvate kinase-deficient patients from Southern Italy.
pyruvate kinase deficiency
Novel mutations associated with pyruvate kinase deficiency in Brazil.
pyruvate kinase deficiency
Novel PLKR mutations in four families with pyruvate kinase deficiency.
pyruvate kinase deficiency
On the molecular basis of pyruvate kinase deficiency.
pyruvate kinase deficiency
On the molecular basis of pyruvate kinase deficiency. I. Primary defect or conseqence of increased glutathione disulfide concentration.
pyruvate kinase deficiency
Parasitic lung infections.
pyruvate kinase deficiency
Paravertebral extramedullary haemopoiesis associated with pyruvate kinase deficiency.
pyruvate kinase deficiency
Paravertebral extramedullary hematopoiesis due to pyruvate kinase deficiency.
pyruvate kinase deficiency
Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
pyruvate kinase deficiency
Partial pyruvate kinase deficiency aggravates the phenotypic expression of band 3 deficiency in a family with hereditary spherocytosis.
pyruvate kinase deficiency
Patient with pyruvate kinase deficiency developed acute myelogenous leukemia.
pyruvate kinase deficiency
Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers.
pyruvate kinase deficiency
Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model.
pyruvate kinase deficiency
Phenylketonuria, pyruvate kinase deficiency and Kouska'a fallacy.
pyruvate kinase deficiency
PK Aarau: first homozygous nonsense mutation causing pyruvate kinase deficiency.
pyruvate kinase deficiency
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
pyruvate kinase deficiency
Point mutations in the L-type pyruvate kinase gene of two children with hemolytic anemia caused by pyruvate kinase deficiency.
pyruvate kinase deficiency
Preclinical studies of efficacy thresholds and tolerability of a clinically ready lentiviral vector for pyruvate kinase deficiency treatment.
pyruvate kinase deficiency
Prenatal diagnosis for a novel homozygous mutation in PKLR gene in an Indian family.
pyruvate kinase deficiency
Prenatal diagnosis of pyruvate kinase deficiency.
pyruvate kinase deficiency
Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study.
pyruvate kinase deficiency
Prevalence of erythrocyte pyruvate kinase deficiency and normal values of enzyme in a Turkish population.
pyruvate kinase deficiency
Prevalence of pyruvate kinase deficiency among the Chinese: determination by the quantitative assay.
pyruvate kinase deficiency
Prevalence of pyruvate kinase deficiency among the south Iranian population: quantitative assay and molecular analysis.
pyruvate kinase deficiency
Prevalence of pyruvate kinase deficiency in northern European population in the north of England. Northern Region Haematologists Group.
pyruvate kinase deficiency
Prevalence of pyruvate kinase deficiency: A systematic literature review.
pyruvate kinase deficiency
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
pyruvate kinase deficiency
Pyruvate kinase deficiency anaemia in a Basenji dog.
pyruvate kinase deficiency
Pyruvate kinase deficiency and delayed clinical response to recombinant human erythropoietin treatment.
pyruvate kinase deficiency
Pyruvate kinase deficiency and leg ulcers.
pyruvate kinase deficiency
Pyruvate kinase deficiency and malaria.
pyruvate kinase deficiency
Pyruvate kinase deficiency and other enzymopathies of the Embden--Meyerhof pathway.
pyruvate kinase deficiency
Pyruvate kinase deficiency and related disorders of red cell glycolysis.
pyruvate kinase deficiency
Pyruvate kinase deficiency and severe congenital hemolytic anemia in a double heterozygous patient with paternal transmission of an early germ-line de novo mutation.
pyruvate kinase deficiency
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
pyruvate kinase deficiency
Pyruvate kinase deficiency as a cause of extreme hyperbilirubinemia in neonates from a polygamist community.
pyruvate kinase deficiency
Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn.
pyruvate kinase deficiency
Pyruvate kinase deficiency causing hemolytic anemia with secondary hemochromatosis in a Cairn terrier.
pyruvate kinase deficiency
Pyruvate kinase deficiency complicating pregnancy.
pyruvate kinase deficiency
Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice.
pyruvate kinase deficiency
Pyruvate kinase deficiency hemolytic anemia: enzymatic characterization studies in twelve patients.
pyruvate kinase deficiency
Pyruvate kinase deficiency hemolytic anemia: two successful pregnancy outcomes.
pyruvate kinase deficiency
Pyruvate kinase deficiency in a newborn with extramedullary hematopoiesis in the skin.
pyruvate kinase deficiency
Pyruvate kinase deficiency in a Somali cat in Australia.
pyruvate kinase deficiency
Pyruvate kinase deficiency in a South African kindred caused by a 1529A mutation in the PK-LR gene.
pyruvate kinase deficiency
Pyruvate kinase deficiency in an alpha-thalassemia family: first case report in Thailand.
pyruvate kinase deficiency
Pyruvate kinase deficiency in children.
pyruvate kinase deficiency
Pyruvate kinase deficiency in dog and human erythrocytes: effects of energy depletion on cation composition and cellular hydration.
pyruvate kinase deficiency
Pyruvate kinase deficiency in France: a 3-year study reveals 27 new mutations.
pyruvate kinase deficiency
Pyruvate kinase deficiency in mice protects against malaria.
pyruvate kinase deficiency
Pyruvate kinase deficiency in pregnancy complicated by iron overload.
pyruvate kinase deficiency
Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria.
pyruvate kinase deficiency
Pyruvate kinase deficiency of mice associated with nonspherocytic hemolytic anemia and cure of the anemia by marrow transplantation without host irradiation.
pyruvate kinase deficiency
Pyruvate kinase deficiency protects against malaria in humans.
pyruvate kinase deficiency
Pyruvate Kinase Deficiency which Causes Nonspherocytic Hemolytic Anemia: The Gene and its Mutations.
pyruvate kinase deficiency
Pyruvate kinase deficiency.
pyruvate kinase deficiency
Pyruvate kinase deficiency. Association with G6PD deficiency.
pyruvate kinase deficiency
Pyruvate kinase deficiency: an unusual cause of puerperal jaundice.
pyruvate kinase deficiency
Pyruvate kinase deficiency: characterization of two new genetic variants.
pyruvate kinase deficiency
Pyruvate kinase deficiency: correlation between enzyme activity, extent of hemolytic anemia and protection against malaria in independent mouse mutants.
pyruvate kinase deficiency
Pyruvate kinase deficiency: novel mutations and a better understanding of the genotype-to-phenotype correlation in Brazilian patients.
pyruvate kinase deficiency
Pyruvate kinase deficiency: prevalence of the 1456C-->T mutation in the Portuguese population.
pyruvate kinase deficiency
Pyruvate kinase deficiency: the genotype-phenotype association.
pyruvate kinase deficiency
Pyruvate kinase deficient hemolytic anemia in the Northern Irish population.
pyruvate kinase deficiency
Pyruvate kinase-catalyzed ATP-formation in human red blood cell membranes.
pyruvate kinase deficiency
Quinine protects pyruvate-kinase deficient red cells from dehydration.
pyruvate kinase deficiency
Rapid flow cytometric test using eosin-5-maleimide for diagnosis of red blood cell membrane disorders.
pyruvate kinase deficiency
Rapid micromethod for the preparation of leucocyte-free haemolysates for the determinaton of pyruvate kinase and other erythrocyte enzymes.
pyruvate kinase deficiency
Real-time PCR genotyping assay for feline erythrocyte pyruvate kinase deficiency and mutant allele frequency in purebred cats in Japan.
pyruvate kinase deficiency
Recurrent thromboembolic disease following splenectomy for pyruvate kinase deficiency.
pyruvate kinase deficiency
Red Blood Cell Enzyme Disorders.
pyruvate kinase deficiency
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
pyruvate kinase deficiency
Red cell 3-phosphoglycerate level as a diagnostic aid in pyruvate kinase deficiency.
pyruvate kinase deficiency
Red cell glycolytic enzyme disorders caused by mutations: an update.
pyruvate kinase deficiency
Red cell pyruvate kinase deficiency in neonatal jaundice cases in India.
pyruvate kinase deficiency
Red cell pyruvate kinase deficiency in Southern Sardinia.
pyruvate kinase deficiency
Red cell pyruvate kinase deficiency in Spain: A study of 15 cases.
pyruvate kinase deficiency
Red cell pyruvate kinase deficiency. The effect of splenectomy.
pyruvate kinase deficiency
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene.
pyruvate kinase deficiency
Red cell pyruvate kinase deficiency: adverse effect of oral contraceptives.
pyruvate kinase deficiency
Red cell pyruvate kinase deficiency: an optimised assay.
pyruvate kinase deficiency
Red cell pyruvate kinase deficiency: from genetics to clinical manifestations.
pyruvate kinase deficiency
Red cell pyruvate kinase deficiency: molecular and clinical aspects.
pyruvate kinase deficiency
Red-cell amino acid transport. Evidence for the presence of system ASC in mature human red blood cells.
pyruvate kinase deficiency
Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency.
pyruvate kinase deficiency
Relative red blood cell enzyme levels as a clue to the diagnosis of pyruvate kinase deficiency.
pyruvate kinase deficiency
Renal allograft tolerance in DLA-identical and haploidentical dogs after nonmyeloablative conditioning and transient immunosuppression with cyclosporine and mycophenolate mofetil.
pyruvate kinase deficiency
Reprogramming homing endonuclease specificity through computational design and directed evolution.
pyruvate kinase deficiency
Rescue of Pyruvate Kinase Deficiency in Mice by Gene Therapy Using the Human Isoenzyme.
pyruvate kinase deficiency
Respiratory characteristics of blood from Basenji dogs with classical erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Reticulocyte-dependent labeling alterations of red cell membrane in pyruvate kinase deficiency anemia.
pyruvate kinase deficiency
RLS with PLMS in a child with hemolytic anemia caused by pyruvate kinase deficiency.
pyruvate kinase deficiency
Roentgenographic manifestations of pyruvate kinase deficiency hemolytic anemia.
pyruvate kinase deficiency
Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
Salicylate-induced injury of pyruvate-kinase-deficient erythrocytes.
pyruvate kinase deficiency
Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters.
pyruvate kinase deficiency
Screening of pyruvate kinase deficiency and G6PD deficiency in Chinese newborn in Hong Kong.
pyruvate kinase deficiency
Secondary red cell pyruvate kinase deficiency. I. Study of 30 subjects of malignant hematological disorders.
pyruvate kinase deficiency
Secondary red cell pyruvate kinase deficiency. II. Biochemical studies for the mechanism of pyruvate kinase deficiency in erythroleukemia.
pyruvate kinase deficiency
Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency.
pyruvate kinase deficiency
Sequestration and destruction of reticulocyte in the spleen in pyruvate kinase deficiency hereditary nonspherocytic hemolytic anemia.
pyruvate kinase deficiency
Severe H1N1-associated acute respiratory failure in immunocompromised children.
pyruvate kinase deficiency
Severe hemolytic anemia in a Vietnamese family, associated with novel mutations in the gene encoding for pyruvate kinase.
pyruvate kinase deficiency
Severe hereditary haemolytic anaemica in dogs treated by marrow trasplantation.
pyruvate kinase deficiency
Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency.
pyruvate kinase deficiency
Severe pyruvate kinase deficiency anemia. A case report.
pyruvate kinase deficiency
Siblings with severe pyruvate kinase deficiency and a complex genotype.
pyruvate kinase deficiency
Sickle cell disease in a carrier with pyruvate kinase deficiency.
pyruvate kinase deficiency
Sickle cell disorders and chronic intravascular haemolysis are associated with low plasma heparin cofactor II.
pyruvate kinase deficiency
Single port robotic splenectomy for pyruvate kinase deficiency in a five-year-old patient, a case report of a surgical first.
pyruvate kinase deficiency
Single-nucleotide substitution in pyruvate kinase deficiency.
pyruvate kinase deficiency
Six Children with Pyruvate Kinase Deficiency from One Small Town: Molecular Characterization of the PK-LR Gene.
pyruvate kinase deficiency
Six novel variants in the PKLR gene associated with pyruvate kinase deficiency in Argentinian patients.
pyruvate kinase deficiency
Six previously undescribed pyruvate kinase mutations causing enzyme deficiency.
pyruvate kinase deficiency
Spectrum and hematological profile of hereditary anemia in North Indians: SGPGI experience.
pyruvate kinase deficiency
Splenectomy in the treatment of hemolytic anemia.
pyruvate kinase deficiency
Splenic macrophage interaction with red cells in pyruvate kinase deficiency and hereditary spherocytosis.
pyruvate kinase deficiency
Spontaneous splenic rupture in primary cytomegalovirus infection.
pyruvate kinase deficiency
Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency.
pyruvate kinase deficiency
Studies on pyruvate kinase deficiency, pyrimidine 5-'nucleotidase deficiency and adenosine deaminase overproduction.
pyruvate kinase deficiency
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
pyruvate kinase deficiency
Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusiondependent pyruvate kinase deficiency anemia.
pyruvate kinase deficiency
Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency.
pyruvate kinase deficiency
Successful Liver Transplants for Liver Failure Associated With Pyruvate Kinase Deficiency.
pyruvate kinase deficiency
Succinylcholine in congenital pyruvate kinase deficiency.
pyruvate kinase deficiency
Surface ultrastructure of pyruvate kinase-deficient erythrocytes in the Basenji dog.
pyruvate kinase deficiency
Targeted next generation sequencing for the diagnosis of patients with rare congenital anemias.
pyruvate kinase deficiency
The autohaemolysis test: appraisal of the method for the diagnosis of pyruvate kinase deficiency and the effect of pH and additives.
pyruvate kinase deficiency
The burden of disease in pyruvate kinase deficiency: Patients' perception of the impact on health-related quality of life.
pyruvate kinase deficiency
The clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study.
pyruvate kinase deficiency
The dangers of iron overload in pyruvate kinase deficiency.
pyruvate kinase deficiency
The Diagnostic Utility of Single Long Contiguous Stretches of Homozygosity in Patients without Parental Consanguinity.
pyruvate kinase deficiency
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
pyruvate kinase deficiency
The diverse forms of the erythrocyte pyruvate kinase deficiency states.
pyruvate kinase deficiency
The metabolic effects of oxalate on intact red blood cells.
pyruvate kinase deficiency
The molecular basis of canine pyruvate kinase deficiency.
pyruvate kinase deficiency
The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.
pyruvate kinase deficiency
The polymorphism of nucleosid effect in pyruvate kinase deficiency.
pyruvate kinase deficiency
The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency.
pyruvate kinase deficiency
The response of the metabolic network of the red blood cell to pyruvate kinase deficiency.
pyruvate kinase deficiency
The variable manifestations of disease in pyruvate kinase deficiency and their management.
pyruvate kinase deficiency
Thirteen cases of pyruvate kinase deficiency found in Japan.
pyruvate kinase deficiency
Three cases of hemolytic anemia with erythrocyte pyruvate kinase deficiency in Alberta.
pyruvate kinase deficiency
Tight linkage of pyruvate kinase (PKLR) and glucocerebrosidase (GBA) genes.
pyruvate kinase deficiency
Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency.
pyruvate kinase deficiency
Treatment and long-term follow-up of extrahepatic biliary obstruction with bilirubin cholelithiasis in a Somali cat with pyruvate kinase deficiency.
pyruvate kinase deficiency
Two cases of pyruvate kinase deficiency: PK 'Kamakura' and PK 'Naniwa'.
pyruvate kinase deficiency
Unexpectedly high but still asymptomatic iron overload in a patient with pyruvate kinase deficiency.
pyruvate kinase deficiency
Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency.
pyruvate kinase deficiency
Utilization of an enzyme heat stability test and erythrocyte glycolytic intermediate assays to assist in the diagnosis of canine pyruvate kinase deficiency.
pyruvate kinase deficiency
Worldwide study of hematopoietic allogeneic stem cell transplantation in pyruvate kinase deficiency.
pyruvate kinase deficiency
[A case of acute granulocytic leukemia with erythrocyte pyruvate kinase deficiency and bone marrow chromosome aberration (author's transl)]
pyruvate kinase deficiency
[A case of familial pyruvate kinase deficiency associated with acute myelomonocytic leukemia]
pyruvate kinase deficiency
[A case of pyruvate kinase deficiency]
pyruvate kinase deficiency
[A family study on pyruvate kinase deficiency anemia]
pyruvate kinase deficiency
[A PKLR Gene Novel Complex Mutation in Erythrocyte Pyruvate Kinase Deficiency Detected by Targeted Sequence Capture and Next Generation Sequencing].
pyruvate kinase deficiency
[Abnormal Michaelis constant for phosphoenol-pyruvate associated with an erythrocyte pyruvate kinase deficiency]
pyruvate kinase deficiency
[Analysis and prenatal diagnosis of PKLR gene mutations in a family with pyruvate kinase deficiency].
pyruvate kinase deficiency
[Analysis of a pyruvate kinase deficiency consanguineous pedigree caused by Ile314Thr homozygous mutation].
pyruvate kinase deficiency
[Biochemical study of 2 cases of congenital pyruvate kinase deficiency]
pyruvate kinase deficiency
[Biochemistry and enzymatic diagnosis of red blood cell pyruvate kinase deficiency]
pyruvate kinase deficiency
[Case of pyruvate kinase deficiency]
pyruvate kinase deficiency
[Chronic non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency in a Costa Rican family carrying hemoglobin C disease]
pyruvate kinase deficiency
[Clinical studies on hereditary nonspherocytic anemia with erythrocyte pyruvate kinase deficiency]
pyruvate kinase deficiency
[Congenital pyruvate kinase deficiency in erythrocytes: kinetic study of the enzyme and metabolic consequences]
pyruvate kinase deficiency
[Constitutional hemolytic anemia due to pyruvate kinase deficiency. Study of 2 families]
pyruvate kinase deficiency
[Contributions to the problem of pyruvate kinase deficiency]
pyruvate kinase deficiency
[Current status of the study of pyruvate kinase deficiency]
pyruvate kinase deficiency
[Deficiency of pyruvate kinase in erythrocytes: biochemical studies. Preliminary communication]
pyruvate kinase deficiency
[Demonstration of an enzyme with abnormal kinetics in 2 new cases of erythrocyte pyruvate kinase deficiency]
pyruvate kinase deficiency
[Diagnosis of pyruvate kinase deficiency in the presence of an elevated reticulocyte count]
pyruvate kinase deficiency
[Diagnosis of pyruvate kinase deficiency]
pyruvate kinase deficiency
[Effect of Magnesium Diasporal on erythrocyte pyruvate kinase activity in healthy persons and in patients with pyruvate kinase deficiency]
pyruvate kinase deficiency
[Efficacy of splenectomy in 2 cases of hemolytic anemia caused by pyruvate kinase deficiency]
pyruvate kinase deficiency
[Ektacytometric determination of the deformability of red blood cells in hemolytic anemia with pyruvate kinase deficiency]
pyruvate kinase deficiency
[Enzymatic diagnosis of red cell pyruvate kinase deficiency]
pyruvate kinase deficiency
[Erythrocyte pyruvate kinase deficiency. Report of a case]
pyruvate kinase deficiency
[Erythrocyte pyruvate kinase deficiency: hemolytic anemia in a heterozygote]
pyruvate kinase deficiency
[Erythrocyte pyruvate kinase deficiency: hemolytic anemia in single and double heterozygotes]
pyruvate kinase deficiency
[Erythrocytic pyruvate kinase deficiency accompanied by a severe neonatal hemolytic anemia. Family study and biochemical characterization of the enzyme]
pyruvate kinase deficiency
[Extramedullary hematopoiesis as differential mediastinal space-occupying lesion diagnosis]
pyruvate kinase deficiency
[Familial erythrocyte ATP: pyruvate phosphotransferase deficiency]
pyruvate kinase deficiency
[From gene to disease; hereditary non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency]
pyruvate kinase deficiency
[Gene analysis and genetic diagnosis of hereditary erythrocyte abnormalities. Pyruvate kinase deficiency]
pyruvate kinase deficiency
[Glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency]
pyruvate kinase deficiency
[Haematopoietic stem cell transplantation in pyruvate kinase deficiency: When is it indicated?]
pyruvate kinase deficiency
[Hemolytic anemia caused by pyruvate kinase deficiency and pregnancy]
pyruvate kinase deficiency
[Hemolytic anemias with pyruvate kinase deficiency]
pyruvate kinase deficiency
[Hereditary elliptocytosis and pyruvate kinase deficiency of the erythrocytes]
pyruvate kinase deficiency
[Hereditary haemolytic anaemia due to pyruvate kinase deficiency. Prognosis of neonatal forms (author's transl)]
pyruvate kinase deficiency
[HEREDITARY HEMOLYTIC ANEMIAS WITH PYRUVATE KINASE DEFICIENCY.]
pyruvate kinase deficiency
[In Process Citation].
pyruvate kinase deficiency
[Inherited hemolytic anemia due to pyruvate kinase deficiency: II. Density-layer centrifugation of erythrocytes (author's transl)]
pyruvate kinase deficiency
[Iron overload in congenital hemolytic anemia caused by pyruvate kinase deficiency. A major late complication]
pyruvate kinase deficiency
[Metabolic studies in a family with 3 cases of congenital non-spherocytic hemolytic anemia with a pyruvate kinase deficiency]
pyruvate kinase deficiency
[Molecular study of red cell pyruvate kinase deficiency in 15 patients with chronic hemolytic anemia. Group of Erythropathology of Hematology and hemotherapy Association of Spain (HHAS)]
pyruvate kinase deficiency
[Neutrophil pyruvate kinase deficiency]
pyruvate kinase deficiency
[Non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency]
pyruvate kinase deficiency
[Nonspherocytic congenital hemolytic anemia induced by a pyruvate kinase deficiency. Presentation of a clinical case]
pyruvate kinase deficiency
[Nonspherocytic hemolytic anemia in pyruvate kinase deficiency]
pyruvate kinase deficiency
[On indications of spleen extirpation in nonspherocytic hemolytic anemias. Favorable success in pyruvate kinase deficiency]
pyruvate kinase deficiency
[Pathophysiology and laboratory tests of hemolytic anemia: with special reference to erythroenzymopathies]
pyruvate kinase deficiency
[Prenatal diagnosis of homozygous pyruvate kinase deficiency]
pyruvate kinase deficiency
[Problems in hemolytic anemias with pyruvate kinase deficiency. I. Clinical and hematologic picture in 4 patients]
pyruvate kinase deficiency
[Problems of erythrocyte metabolism in anemias with pyruvate kinase deficiency]
pyruvate kinase deficiency
[Proceedings: A new case of pyruvate kinase deficiency]
pyruvate kinase deficiency
[Pyrivate kinase deficiency. II. Biochemical studies (author's transl)]
pyruvate kinase deficiency
[Pyruvate kinase deficiency and some problems of glycolysis regulation]
pyruvate kinase deficiency
[Pyruvate kinase deficiency ass3ciated with nonspherocytic hemolytic anemia. Biochemical hematological study of 3 cases]
pyruvate kinase deficiency
[Pyruvate kinase deficiency hereditary hemolytic anemia (author's transl)]
pyruvate kinase deficiency
[PYRUVATE KINASE DEFICIENCY HEREDITARY NONSPHEROCYTIC HEMOLYTIC ANEMIA. REPORT OF TWO CASES IN A JAPANESE FAMILY AND REVIEW OF LITERATURE.]
pyruvate kinase deficiency
[Pyruvate kinase deficiency in a patient with beta-thalassemia]
pyruvate kinase deficiency
[Pyruvate kinase deficiency in hereditary, non-spherocytic hemolytic anemia]
pyruvate kinase deficiency
[Pyruvate kinase deficiency in the German Democratic Republic]
pyruvate kinase deficiency
[Pyruvate kinase deficiency in the newborn infant]
pyruvate kinase deficiency
[Pyruvate kinase deficiency of erythrocytes in a case of hereditary myopathy]
pyruvate kinase deficiency
[Pyruvate kinase deficiency, infectious mononucleosis, hemolytic anemia with cold autoantibodies and massive splenic infarction]
pyruvate kinase deficiency
[Pyruvate kinase deficiency. I. Clinical and hematological observations (author's transl)]
pyruvate kinase deficiency
[Pyruvate kinase deficiency]
pyruvate kinase deficiency
[Regulation of the carbohydrate metabolism of the erythrocytes in pyruvate kinase deficiency]
pyruvate kinase deficiency
[Research on the molecular anomaly in erythrocyte pyruvate kinase deficiency]
pyruvate kinase deficiency
[Significance of kinetic abnormalities of erythrocyte pyruvate kinase in congenital deficiencies]
pyruvate kinase deficiency
[Splenectomized pyruvate kinase deficiency hemolytic anemia with positive Coombs' test: report of a case with family study (author's transl)]
pyruvate kinase deficiency
[Studies on erythrocyte metabolism in various hemolytic anemias: with special reference to pyruvate kinase deficiency]
pyruvate kinase deficiency
[The clinical and laboratory characteristics of congenital pyruvate kinase deficiency].
pyruvate kinase deficiency
[The importance of determination of ferritin levels in erythrocytes]
pyruvate kinase deficiency
[The modified "pink test" in the diagnosis of hereditary spherocytosis]
pyruvate kinase deficiency
[Thirteen cases of erythrocyte pyruvate kinase deficiency associated with hereditary hemolytic anemia--clinical and biochemical studies (author's transl)]
pyruvate kinase deficiency
[Use of nuclear magnetic resonance in the study of hemolytic anemia. Preliminary report]
pyruvate kinase deficiency
[Variations in the expression of the pyruvate kinase deficiency of erythrocytes]
pyruvate kinase deficiency
[Vascular complications in a case of hemolytic anemia due to pyruvate kinase deficiency]
Renal Insufficiency
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Respiratory Distress Syndrome, Newborn
A novel mutation causing pyruvate kinase deficiency responsible for a severe neonatal respiratory distress syndrome and jaundice.
Respiratory Insufficiency
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Retinal Diseases
Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders.
Retinoblastoma
Characterization of some glycolytic enzymes from human retina and retinoblastoma.
Retinoblastoma
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Retinoblastoma
The double dealing of cyclin D1.
Rhabdomyosarcoma
Characterization of pyruvate kinase from human rhabdomyosarcoma in relation to immunohistochemical and morphological criteria.
Rheumatic Diseases
Pre-analytical problems in the measurement of tumor type pyruvate kinase (tumor M2-PK).
Rheumatic Diseases
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Sarcoma
Crystallization of spleen-type (M2-type) pyruvate kinase from Rhodamine sarcoma of rats and its properties.
Sarcoma
Effect of injection of chromatins from rhodamine sarcoma into rats on pI-isozymes of liver pyruvate kinase.
Sarcoma
Horse v-fes feline sarcoma viral oncogene homologue; pyruvate kinase, muscle type 2; plasminogen; beta spectrin, non-erythrocytic 1; thymidylate synthetase; and microsatellite LEX078 map to 1q14-q15, 1q21, 31q12-q14, 15q22, 8q12-q14, and 14q27, respectively.
Sarcoma
Intralipid decreases apolipoprotein M levels and insulin sensitivity in rats.
Sarcoma
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
Sarcoma
[Glycolysis of ascites Tawa sarcoma cells. Inhibitory effect of alanine on pyruvate kinase activity]
Sarcoma
[Glycolytic metabolism in Tawa sarcoma cells--inhibition of pyruvate kinase activity from Tawa sarcoma cells by alanine and phenylalanine]
Sarcoma
[Immunohistochemical demonstration of pyruvate kinase isoenzyme in the organs and a sarcoma of the hen]
Sarcoma
[Purification of pyruvate kinase from ascites Tawa sarcoma cells]
Sarcoma, Avian
Carbohydrate metabolism in neoplastic tissue.
Sarcoma, Avian
Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus.
Sarcoma, Avian
Similarities between a phosphoprotein (pp60src)-associated protein kinase of Rous sarcoma virus and a cyclic adenosine 3':5'-monophosphate-independent protein kinase that phosphorylates pyruvate kinase type M2.
Sarcoma, Avian
Structural and kinetic differences between the M2 type pyruvate kinases from lung and various tumors.
Sarcoma, Kaposi
KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma.
Sepsis
Deoxyelephantopin decreases the release of inflammatory cytokines in macrophage associated with attenuation of aerobic glycolysis via modulation of PKM2.
Sepsis
Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis, gluconeogenesis, and flux through phosphoenolpyruvate carboxykinase.
Sepsis
Global Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identified Hyperacetylation of PKM2 as a Metabolic Regulator in Sepsis.
Sepsis
PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1? Secretion.
Sepsis
Protein phosphorylation in isolated hepatocytes of septic and endotoxemic rats.
Severe Combined Immunodeficiency
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Shock, Septic
Deoxyelephantopin decreases the release of inflammatory cytokines in macrophage associated with attenuation of aerobic glycolysis via modulation of PKM2.
Shock, Septic
Effect of treatment in vivo of rats with bacterial endotoxin on fructose 2,6-bisphosphate metabolism and L-pyruvate kinase activity and flux in isolated liver cells.
Shock, Septic
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Short Bowel Syndrome
Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review.
Sickle Cell Trait
Human red blood cell polymorphisms and malaria.
Sickle Cell Trait
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
Skin Neoplasms
PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells.
Skin Neoplasms
Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation.
Sleep Deprivation
Proteomic analysis of rat serum revealed the effects of chronic sleep deprivation on metabolic, cardiovascular and nervous system.
Spinal Cord Injuries
Recovery of motor function of chronic spinal cord injury by extracellular pyruvate kinase isoform M2 and the underlying mechanism.
Splenic Infarction
[Pyruvate kinase deficiency, infectious mononucleosis, hemolytic anemia with cold autoantibodies and massive splenic infarction]
Spondylarthritis
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Sprue, Tropical
Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review.
Squamous Cell Carcinoma of Head and Neck
Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Squamous Cell Carcinoma of Head and Neck
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer.
Staphylococcal Infections
Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections.
Staphylococcal Infections
Neutrophil pyruvate kinase deficiency with recurrent staphylococcal infections: first reported case.
Starvation
A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro.
Starvation
Age-dependent changes in rat hepatic fructose 2, 6-bisphosphate, 6-phosphofructo-2-kinase/fructose 2, 6-bisphosphatase and pyruvate kinase activity in response to a high protein diet or starvation.
Starvation
Age-dependent glycolysis and gluconeogenesis enzyme activities in starved-refed rats.
Starvation
Alteration in liver pyruvate kinase protein and catalytic acitivity upon starvation and refeeding.
Starvation
Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression.
Starvation
Development of gluconeogenesis from dihydroxyacetone in rat hepatocytes during a feeding cycle and starvation.
Starvation
Difference in the effect of glucagon and starvation upon L-type pyruvate kinase from rat liver.
Starvation
Disruption of the phosphate-starvation response of oilseed rape suspension cells by the fungicide phosphonate.
Starvation
Effect of glucagon and starvation on L-type pyruvate kinase from rat liver [proceedings]
Starvation
Enzyme activities of hepatic glucose utilization in the fed and fasting genetically obese mouse at 4-5 months of age.
Starvation
Genetically Based Physiological Responses to Overwinter Starvation in Gibel Carp (Carassius gibelio).
Starvation
Hormone-induced changes in pyruvate kinase. Effects of glucagon and starvation.
Starvation
In vivo factors influencing tumour M2-pyruvate kinase level in human pancreatic cancer cell lines.
Starvation
Inhibition of carbon dioxide fixation by lead acetate in rat liver mitochondria.
Starvation
Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacterium Lactobacillus acidophilus NCFM.
Starvation
Phosphate Starvation Inducible ;Bypasses' of Adenylate and Phosphate Dependent Glycolytic Enzymes in Brassica nigra Suspension Cells.
Starvation
Purification and Characterization of a Phosphoenolpyruvate Phosphatase from Brassica nigra Suspension Cells.
Starvation
Starvation and feeding with a high-carbohydrate diet induce changes in the specific activity of rat hepatic pyruvate kinase.
Starvation
Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics.
Starvation
Transcriptional and post-transcriptional regulation of L-type pyruvate kinase gene expression in rat liver.
Starvation
[Effect of insulin and hydrocortisone on pyruvate kinase from the medullar and cortical layers of rabbit kidney]
Starvation
[Effect of insulin and hydrocortisone on the isoenzyme composition of pyruvate kinase in the rabbit kidney]
Starvation
[Effect of starvation, cortisol and insulin on the activities of pyruvate carboxylase, phosphopyruvate carboxylase (PEP-carboxykinase) and pyruvate kinase in the liver of NZo mice in various stages of diabetes]
Starvation
[On molecular biology of aging. 11th communication. Enzyme adaptation, age (author's transl)]
Stomach Neoplasms
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Stomach Neoplasms
Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.
Stomach Neoplasms
Fecal pyruvate kinase concentrations (ELISA based on a combination of clone 1 and clone 3 antibodies) for gastric cancer screening.
Stomach Neoplasms
Improved sensitivity in the diagnosis of gastro-intestinal tumors by fuzzy logic-based tumor marker profiles including the tumor M2-PK.
Stomach Neoplasms
LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2.
Stomach Neoplasms
Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.
Stomach Neoplasms
Metformin inhibits gastric cancer via the inhibition of HIF1?/PKM2 signaling.
Stomach Neoplasms
MiR-133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle-splicer polypyrimidine tract-binding protein 1.
Stomach Neoplasms
OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels.
Stomach Neoplasms
Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer.
Stomach Neoplasms
Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer.
Stomach Neoplasms
Pyruvate kinase M2 contributes to cell growth in gastric cancer via aerobic glycolysis.
Stomach Neoplasms
Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells.
Stomach Neoplasms
Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.
Stomach Neoplasms
Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1/PKM2/GLUT1 expression.
Stomach Neoplasms
The Value of Expression of M2-PK and VEGF in Patients with Advanced Gastric Cancer.
Stomach Neoplasms
Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls.
Stomach Neoplasms
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Testicular Neoplasms
Plasma Tumor M2-Pyruvate Kinase Levels in Different Cancer Types.
Testicular Neoplasms
The aldolase and pyruvate kinase isoenzyme patterns in a malignant testicular tumor from a 27 year old male.
Testicular Neoplasms
Tu-M2-PK in the blood of testicular and cubital veins in men with testicular cancer.
Thalassemia
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Thalassemia
Hepcidin and Anemia: A Tight Relationship.
Thalassemia
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Thalassemia
Preliminary observations on the activity of pyruvate kinase in Hb. E thalassemia disease.
Thalassemia
Spectrum and hematological profile of hereditary anemia in North Indians: SGPGI experience.
Thalassemia
Splenectomy in the treatment of hemolytic anemia.
Thiamine Deficiency
[Isoenzyme spectrum and kinetic properties of pyruvate kinase from the liver of thiamine-deficient rats]
Thrombasthenia
Renal allograft tolerance in DLA-identical and haploidentical dogs after nonmyeloablative conditioning and transient immunosuppression with cyclosporine and mycophenolate mofetil.
Thrombocytopenia
Atypical intraerythrocytic pyruvate kinase in some haematological diseases.
Thrombocytopenia
Intra-erythrocytary enzymes before and after splenectomy.
Thrombosis
The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis.
Thrombosis
Variations in platelet protein associated with arterial thrombosis.
Thrombosis
[The action of pyruvate kinase and phosphoenolpyruvate on the development of experimental thrombosis]
Thrombotic Microangiopathies
How I do in front of an hemolytic anemia of unknown etiology?
Thymus Neoplasms
Neoplastic transformation and angiogenesis in the thymus of transgenic mice expressing SV40 T and t antigen under an L-pyruvate kinase promoter (SV12 mice).
Thyroid Cancer, Papillary
Aberrant Overexpression of Pyruvate Kinase M2 Is Associated With Aggressive Tumor Features and the BRAF Mutation in Papillary Thyroid Cancer.
Thyroid Diseases
Value of tumor M2-PK in thyroid carcinoma: a pilot study.
Thyroid Neoplasms
Glucose-deprivation increases thyroid cancer cells sensitivity to metformin.
Thyroid Neoplasms
Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2.
Thyroid Neoplasms
PKM2 functions as a potential oncogene and is a crucial target of miR-148a and miR-326 in thyroid tumorigenesis.
Thyroid Neoplasms
Pyruvate kinase in normal human thyroid tissue and thyroid neoplasms.
Thyroid Neoplasms
Pyruvate kinase isozymes and dedifferentiation of (neuro-)ectodermal tumors.
Thyroid Neoplasms
Subunit-specific phosphorylation of pyruvate kinase in medullary thyroid carcinomas of the rat.
Thyroid Neoplasms
Value of tumor M2-PK in thyroid carcinoma: a pilot study.
Thyroid Neoplasms
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
Tongue Neoplasms
Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response.
Tourette Syndrome
Identification of pyruvate kinase as an antigen associated with Tourette syndrome.
Toxoplasmosis
Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies.
triose-phosphate isomerase deficiency
Increased erythrocyte deformability in fetal erythropoiesis and in erythrocytes deficient in glucose-6-phosphate dehydrogenase and other glycolytic enzymes.
Triple Negative Breast Neoplasms
Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.
Triple Negative Breast Neoplasms
Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells.
Tuberculosis
Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Tuberculosis
Allosteric regulation of pyruvate kinase from Mycobacterium tuberculosis by metabolites.
Tuberculosis
Central Role of Pyruvate Kinase in Carbon Co-catabolism of Mycobacterium tuberculosis.
Tuberculosis
Expression, purification, and characterization of pyruvate kinase from Mycobacterium tuberculosis: A key allosteric regulatory enzyme.
Tuberculosis
Global effects of inactivation of the pyruvate kinase gene in the Mycobacterium tuberculosis complex.
Tuberculosis
Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis.
Tuberculosis
Rewiring of Metabolic Network in Mycobacterium tuberculosis During Adaptation to Different Stresses.
Tuberculosis
The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: implications for in vivo growth.
Tuberculosis
Understanding the role of PknJ in Mycobacterium tuberculosis: biochemical characterization and identification of novel substrate pyruvate kinase A.
Uremia
Effect of chronic uremia on fructose 2,6-bisphosphate glycolytic and gluconeogenic enzymes in rat liver.
Uremia
Effects of chronic renal failure on the regulation of pyruvate kinase.
Urinary Bladder Neoplasms
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis.
Urinary Bladder Neoplasms
Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial-Mesenchymal Transition.
Urinary Bladder Neoplasms
Expression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis.
Urinary Bladder Neoplasms
Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin.
Urinary Bladder Neoplasms
Proteomic analysis of bladder cancer by iTRAQ after Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene treatment.
Urinary Bladder Neoplasms
Pyruvate kinase M2 inhibits the progression of bladder cancer by targeting MAKP pathway.
Urinary Bladder Neoplasms
Tumor M2-PK: A novel urine marker of bladder cancer.
Urinary Tract Infections
Flexible Metabolism and Suppression of Latent Enzymes Are Important for Escherichia coli Adaptation to Diverse Environments within the Host.
Uterine Cervical Neoplasms
Fructose-1,6-bisphosphatase 2 represses cervical cancer progression via inhibiting aerobic glycolysis through promoting pyruvate kinase isozyme type M2 ubiquitination.
Uterine Cervical Neoplasms
KCNQ1 opposite strand/antisense transcript 1 promotes aggressive biological behaviors of cervical cancer cells via regulating microRNA-491-5p and pyruvate kinase M1/2.
Uterine Cervical Neoplasms
Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-?1 (TGF-?1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells.
Uterine Cervical Neoplasms
Tumor-specific correlation of tumor M2 pyruvate kinase in pre-invasive, invasive and recurrent cervical cancer.
Uterine Cervicitis
Evaluation of the Pyruvate Kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for cervical carcinoma.
Virus Diseases
Influenza Virus Infection Induces Host Pyruvate Kinase M Which Interacts with Viral RNA-Dependent RNA Polymerase.
Vitamin E Deficiency
A Plasma ?-Tocopherome Can Be Identified from Proteins Associated with Vitamin E Status in School-Aged Children of Nepal.
Vitamin E Deficiency
Correlation between plasma alpha-cysteine proteinase inhibitor level and pyruvate kinase activity in vitamin E-deficient rats.
Vitamin E Deficiency
Effect of ascorbic acid and vitamin E on biochemical changes associated with vitamin E deficiency in rats.
Vitamin E Deficiency
Effects of vitamin E on toxicity by minute amounts of paraquat fed continuously to rats.
Vitamin E Deficiency
Mechanisms of hemolysis in liver disease.
Vitamin E Deficiency
Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low alpha-tocopherol diet.
Vitamin E Deficiency
The effect of dietary vitamin E and beta-carotene on oxidation processes in the rat testis.
Vitiligo
Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin.
Whooping Cough
Bordetella pertussis extract induces increase in the activities of glycolytic enzymes in mouse liver.
Wiskott-Aldrich Syndrome
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
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2.7.1.40 pyruvate kinase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
