Information on EC 2.7.1.28 - triokinase

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The expected taxonomic range for this enzyme is: Rodentia

EC NUMBER
COMMENTARY hide
2.7.1.28
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RECOMMENDED NAME
GeneOntology No.
triokinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Fructose and mannose metabolism
-
-
sucrose degradation V (sucrose alpha-glucosidase)
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:D-glyceraldehyde 3-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9030-65-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
caloric restricted young (3 months) and old (30 months) male C57BL/6J mice
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + D-glyceraldehyde
ADP + D-glyceraldehyde-3-phosphate
show the reaction diagram
ATP + dihydroxyacetone
ADP + dihydroxyacetone phosphate
show the reaction diagram
ATP + glyceraldehyde
ADP + D-glyceraldehyde-3-phosphate
show the reaction diagram
GTP + D-glyceraldehyde
GDP + D-glyceraldehyde-3-phosphate
show the reaction diagram
-
10% of the activity with ATP
-
?
ITP + D-glyceraldehyde
IDP + D-glyceraldehyde-3-phosphate
show the reaction diagram
-
14% of the activity with ATP
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + D-glyceraldehyde
ADP + D-glyceraldehyde-3-phosphate
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required in equimolar concentration with ATP
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ADP
-
free ADP, 0.5 mM, 50% inhibition, competitive to MgATP2-, noncompetitive to D-glyceraldehyde
ATP
-
free ATP, 1.5 mM, 50% inhibition, competitive to MgATP2-, noncompetitive to D-glyceraldehyde
MgADP-
-
free, competitive to MgATP2-, noncompetitive to D-glyceraldehyde
additional information
-
not inhibited by Zn2+
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.008 - 0.019
D-glyceraldehyde
0.006
dihydroxyacetone
-
pH 7.5, 23-24C, at 2 mM ATPMg2-
0.01
glyceraldehyde
-
pH 7.0, 22C
0.16 - 0.24
MgATP2-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.1
ADP
-
pH 7.5, 23-24C
0.38
ATP
-
pH 7.5, 23-24C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0024
-
activity in the liver of female rats fed with fructose diet containing copper-adequate
0.0034
-
activity in the liver of male rats fed with fructose diet containing copper-adequate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partially purified
-