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Information on EC 2.7.1.24 - dephospho-CoA kinase and Organism(s) Homo sapiens and UniProt Accession Q13057

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Homo sapiens
UNIPROT: Q13057 not found.
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
coenzyme a synthase, dpck, dephospho-coa kinase, dephosphocoenzyme a, dephosphocoenzyme a kinase, tk1697, dephospho-coenzyme a kinase, ehdpck1, ehdpck2, gtp-dependent dpck, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3'-dephospho-CoA kinase
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-
-
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coenzyme A synthase
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a bifunctional enzyme that also shows dephosphocoenzyme A kinase activity
dephosphocoenzyme A kinase
dephosphocoenzyme A kinase (phosphorylating)
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kinase, dephosphocoenzyme A (phosphorylating)
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additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
ATP:3'-dephospho-CoA 3'-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-83-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + dephospho-CoA
ADP + CoA
show the reaction diagram
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-
?
ATP + 3'-dephospho-CoA
ADP + CoA
show the reaction diagram
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-
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-
?
ATP + dephospho-CoA
ADP + CoA
show the reaction diagram
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-
-
-
?
ATP + dephospho-tryptamine-CoA
ADP + tryptamine-CoA
show the reaction diagram
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-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDC4
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EDC4 is also known as Ge-1, Hedls, RCD-8. EDC4 strongly inhibits the dephospho-CoA kinase activity of coenzyme A synthase in vitro
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.19
ATP
recombinant enzyme, pH 8.0, 25°C
0.0052
dephospho-CoA
recombinant enzyme, pH 8.0, 25°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene ppat/dpck, bifunctional enzyme with phosphopantetheine adenylyltransferase and dephospho-CoA kinase activities, termed CoA synthase
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
COASY_HUMAN
564
0
62329
Swiss-Prot
Secretory Pathway (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
62000
recombinant enzyme, gel filtration
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant from Escherichia coli
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene ppat/dpck encoding bifunctional enzyme with phosphopantetheine adenylyltransferase and dephospho-CoA kinase activity, located on chromosome 17q12-21, DNA sequence determination and analysis, expression in Escherichia coli BL21(DE3)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
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dephospho-CoA kinase provides a rapid and sensitive radiochemical assay for coenzyme A and its thioesters. The DPCK method can be applied accurately to pools of CoA metabolites isolated from cellular material
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Aghajanian, S.; Worrall, D.M.
Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)
Biochem. J.
365
13-18
2002
Homo sapiens (Q13057), Homo sapiens, Sus scrofa (Q8MIR4), Sus scrofa
Manually annotated by BRENDA team
Wadler, C.; Cronan, J.E.
Dephospho-CoA kinase provides a rapid and sensitive radiochemical assay for coenzyme A and its thioesters
Anal. Biochem.
368
17-23
2007
Aquifex aeolicus, Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Hwang, Y.; Ganguly, S.; Ho, A.K.; Klein, D.C.; Cole, P.A.
Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug
Bioorg. Med. Chem.
15
2147-2155
2007
Homo sapiens
Manually annotated by BRENDA team
Gudkova, D.; Panasyuk, G.; Nemazanyy, I.; Zhyvoloup, A.; Monteil, P.; Filonenko, V.; Gout, I.
EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase
FEBS Lett.
586
3590-3595
2012
Homo sapiens
Manually annotated by BRENDA team