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Information on EC 2.7.1.21 - thymidine kinase and Organism(s) Gallus gallus and UniProt Accession P04047

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IUBMB Comments
Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP---thymidine kinase), EC 2.7.1.118 (ADP---thymidine kinase) and EC 2.7.4.9 (dTMP-kinase).
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This record set is specific for:
Gallus gallus
UNIPROT: P04047
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
thymidine kinase, hsv1-tk, calmodulin-binding protein, thymidine kinase 1, thymidylate kinase, type 1 thymidine kinase, hsv-1 tk, thymidine kinase 2, mitochondrial thymidine kinase, cam-binding protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
thymidine kinase 1
-
2'-deoxythymidine kinase
-
-
-
-
ATP-thymidine 5'-phosphotransferase
-
-
-
-
EC 2.7.1.75
-
-
-
-
kinase, deoxythymidine (phosphorylating)
-
-
-
-
kinase, thymidine (phosphorylating)
-
-
-
-
TdR kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:thymidine 5'-phosphotransferase
Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP---thymidine kinase), EC 2.7.1.118 (ADP---thymidine kinase) and EC 2.7.4.9 (dTMP-kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
9002-06-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + thymidine
ADP + dTMP
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0012 - 0.012
thymidine
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KITH_CHICK
224
0
24872
Swiss-Prot
other Location (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
24800
4 * 24800, calculated from amino acid sequence
46000
gel filtration
25500
-
calculated from amino acid sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homotetramer
4 * 24800, calculated from amino acid sequence
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kit, S.
Thymidine kinase
Microbiol. Sci.
2
369-375
1985
Gallus gallus, Cytomegalovirus, Homo sapiens, Betapolyomavirus macacae
Manually annotated by BRENDA team
Kit, S.; Leung, W.C.; Trkula, D.; Dubbs, D.R.
Characterization of nucleoside phosphotransferase and thymidine kinase activities of chick embryo cells and of chick-mouse somatic cell hybrids
Arch. Biochem. Biophys.
169
66-76
1975
Anas sp., Gallus gallus
Manually annotated by BRENDA team
Sandrini, M.P.; Clausen, A.R.; Munch-Petersen, B.; Piskur, J.
Thymidine kinase diversity in bacteria
Nucleosides Nucleotides Nucleic Acids
25
1153-1158
2006
Bacillus cereus, Bacillus subtilis, Clostridium perfringens, Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, Xanthomonas campestris, Streptomyces coelicolor (O50519), Gallus gallus (P04047), Homo sapiens (P04183), Mus musculus (P04184), Yersinia enterocolitica (Q0H7D6), Solanum lycopersicum (Q71F77), Salmonella enterica subsp. enterica serovar Typhi (Q8XFQ8), Clostridium acetobutylicum (Q97F65), Arabidopsis thaliana (Q9FN47), Arabidopsis thaliana (Q9S750), Ureaplasma parvum (Q9PPP5), Deinococcus radiodurans (Q9RSY5)
Manually annotated by BRENDA team
Mutahir, Z.; Clausen, A.R.; Andersson, K.M.; Wisen, S.M.; Munch-Petersen, B.; Piskur, J.
Thymidine kinase 1 regulatory fine-tuning through tetramer formation
FEBS J.
280
1531-1541
2013
Anolis carolinensis (C3VAL3), Caenorhabditis elegans (G5EEZ5), Gallus gallus (P04047), Homo sapiens (P04183), Homo sapiens, Rattus norvegicus (P27158), Bacillus cereus (Q0H0H6), Dictyostelium discoideum (Q27564), Xenopus tropicalis (Q5I0A2), Danio rerio (Q803Y1), Arabidopsis thaliana (Q9S750 and Q9FN47)
Manually annotated by BRENDA team