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Information on EC 2.7.1.21 - thymidine kinase and Organism(s) Streptomyces coelicolor and UniProt Accession O50519

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IUBMB Comments
Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP---thymidine kinase), EC 2.7.1.118 (ADP---thymidine kinase) and EC 2.7.4.9 (dTMP-kinase).
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This record set is specific for:
Streptomyces coelicolor
UNIPROT: O50519
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Word Map
The taxonomic range for the selected organisms is: Streptomyces coelicolor
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
thymidine kinase, hsv1-tk, calmodulin-binding protein, thymidine kinase 1, thymidylate kinase, type 1 thymidine kinase, hsv-1 tk, thymidine kinase 2, mitochondrial thymidine kinase, cam-binding protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2'-deoxythymidine kinase
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ATP-thymidine 5'-phosphotransferase
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EC 2.7.1.75
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kinase, deoxythymidine (phosphorylating)
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kinase, thymidine (phosphorylating)
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TdR kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:thymidine 5'-phosphotransferase
Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP---thymidine kinase), EC 2.7.1.118 (ADP---thymidine kinase) and EC 2.7.4.9 (dTMP-kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
9002-06-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
the thymidine kinases from Gram-positive bacteria are more closely related to the eukaryotic thymidine kinase 1 enzymes than are thymidine kinases from Gram-negative bacteria
SwissProt
Manually annotated by BRENDA team
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sandrini, M.P.; Clausen, A.R.; Munch-Petersen, B.; Piskur, J.
Thymidine kinase diversity in bacteria
Nucleosides Nucleotides Nucleic Acids
25
1153-1158
2006
Bacillus cereus, Bacillus subtilis, Clostridium perfringens, Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, Xanthomonas campestris, Streptomyces coelicolor (O50519), Gallus gallus (P04047), Homo sapiens (P04183), Mus musculus (P04184), Yersinia enterocolitica (Q0H7D6), Solanum lycopersicum (Q71F77), Salmonella enterica subsp. enterica serovar Typhi (Q8XFQ8), Clostridium acetobutylicum (Q97F65), Arabidopsis thaliana (Q9FN47), Arabidopsis thaliana (Q9S750), Ureaplasma parvum (Q9PPP5), Deinococcus radiodurans (Q9RSY5)
Manually annotated by BRENDA team