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Information on EC 2.7.1.172 - protein-ribulosamine 3-kinase and Organism(s) Mus musculus and UniProt Accession Q8K274

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IUBMB Comments
This enzyme plays a role in freeing proteins from ribulosamines or psicosamines, which might arise from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by EC 2.7.1.171 (protein-fructosamine 3-kinase), which has, in addition, the unique capacity to phosphorylate fructosamines . The plant enzyme also phosphorylates [protein]-N6-D-erythrulosyl-L-lysine . No activity with [protein]-N6-D-fructosyl-L-lysine [1,2].
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Mus musculus
UNIPROT: Q8K274
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fn3krp, fn3k-rp, fn3k-related protein, fructosamine-3-kinase-related protein, ribulosamine/erythrulosamine 3-kinase, fructosamine 3-kinase-related protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
FN3K-related protein
-
fructosamine-3-kinase–related protein
-
ketosamine 3-kinase 2
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-N6-D-ribulosyl-L-lysine 3-phosphotransferase
This enzyme plays a role in freeing proteins from ribulosamines or psicosamines, which might arise from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by EC 2.7.1.171 (protein-fructosamine 3-kinase), which has, in addition, the unique capacity to phosphorylate fructosamines [1]. The plant enzyme also phosphorylates [protein]-N6-D-erythrulosyl-L-lysine [2]. No activity with [protein]-N6-D-fructosyl-L-lysine [1,2].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
highest levels of expression in bone marrow, brain, spleen, kidney, and lens
Manually annotated by BRENDA team
highest levels of expression in bone marrow, brain, spleen, kidney, and lens
Manually annotated by BRENDA team
expressed at low levels
Manually annotated by BRENDA team
highest levels of expression in bone marrow, brain, spleen, kidney, and lens
Manually annotated by BRENDA team
highest levels of expression in bone marrow, brain, spleen, kidney, and lens
Manually annotated by BRENDA team
expressed at low levels
Manually annotated by BRENDA team
expressed at low levels
Manually annotated by BRENDA team
highest levels of expression in bone marrow, brain, spleen, kidney, and lens
Manually annotated by BRENDA team
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KT3K_MOUSE
309
0
34468
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
34440
x * 34440, calculated from sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 34440, calculated from sequence
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme, partially purified by chromatography on Blue Sepharose
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
human FN3K-RP is transfected in human embryonic kidney cells and expressed
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Collard, F.; Delpierre, G.; Stroobant, V.; Matthijs, G.; van Schaftingen, E.
A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines
Diabetes
52
2888-2895
2004
Mus musculus (Q8K274), Mus musculus, Homo sapiens (Q9HA64), Homo sapiens
Manually annotated by BRENDA team