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Disease on EC 2.7.1.149 - 1-phosphatidylinositol-5-phosphate 4-kinase and Organism(s) Homo sapiens and UniProt Accession Q8TBX8

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Cl(-)-ATPase in rat brain and kidney.
Amyotrophic Lateral Sclerosis
VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway.
Astrocytoma
Inhibition of beta(2)-adrenergic and muscarinic cholinergic receptor endocytosis after depletion of phosphatidylinositol bisphosphate.
Autoimmune Diseases
PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity.
Bacterial Infections
Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks.
Breast Neoplasms
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma.
Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.
Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.
Carcinogenesis
PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis.
Regulatory Network and Prognostic Effect Investigation of PIP4K2A in Leukemia and Solid Cancers.
Carcinoma
Phosphatidylinositol 4-kinase assay in ovarian carcinoma cells.
Signalling and non-caveolar rafts.
The tetraspanin D6.1A and its molecular partners on rat carcinoma cells.
Carcinoma, Hepatocellular
Overexpression of phosphatidylinositol 4-kinase type III? is associated with undifferentiated status and poor prognosis of human hepatocellular carcinoma.
Colonic Neoplasms
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma.
Cystic Fibrosis
Distinct and specific functions of cGMP-dependent protein kinases.
Deafness
Phosphatidylinositol 4-kinase ? mutations cause nonsyndromic sensorineural deafness and inner ear malformation.
Dehydration
Importance of inositols and their derivatives in cowpea under root dehydration: An omics perspective.
Diabetes Mellitus, Type 2
Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.
Encephalitis
Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.
Fibrosarcoma
Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.
Gallbladder Neoplasms
C24 -Ceramide Drives Gallbladder Cancer Progression through Directly Targeting PIP4K2C to Facilitate mTOR Signaling Activation.
Glioblastoma
PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma.
Hematologic Neoplasms
Differential profile of PIP4K2A expression in hematological malignancies.
Identification and characterization of human ARHGAP23 gene in silico.
PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia.
Hepatitis C
Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.
Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase III? (PI4KB).
Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase III? to induce mitochondrial fragmentation.
Hepatitis C Virus NS5A Protein Interacts with Phosphatidylinositol 4-Kinase Type III{alpha} and Regulates Viral Propagation.
Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication.
High-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay.
Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication.
Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase III? and Oxysterol-Binding Protein.
Novel phosphatidylinositol 4-kinases III beta (PI4KIII?) inhibitors discovered by virtual screening using free energy models.
Overexpression of phosphatidylinositol 4-kinase type III? is associated with undifferentiated status and poor prognosis of human hepatocellular carcinoma.
Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels.
The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement.
Tyrphostin AG1478 inhibits encephalomyocarditis virus and hepatitis C virus by targeting phosphatidylinositol 4-kinase III?.
Herpes Simplex
Deoxythymidine kinase induced in HeLa TK- cells by herpes simplex virus type I and type II. II. Purification and characterization.
Immune System Diseases
Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.
Infections
A phase 1, placebo controlled, randomised, single ascending dose study and a volunteer infection study to characterize the safety, pharmacokinetics and antimalarial activity of the Plasmodium phosphatidylinositol 4-kinase inhibitor MMV390048.
Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.
Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening.
Insulin Resistance
Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta.
Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.
MANF regulates hypothalamic control of food intake and body weight.
Leukemia
Differential profile of PIP4K2A expression in hematological malignancies.
FcepsilonRI cross-linking activates a type II phosphatidylinositol 4-kinase in RBL 2H3 cells.
Regulatory Network and Prognostic Effect Investigation of PIP4K2A in Leukemia and Solid Cancers.
Leukemia, Myeloid, Acute
A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.
Differential profile of PIP4K2A expression in hematological malignancies.
Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase.
PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia.
Lymphatic Metastasis
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma.
Malaria
Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Myelodysplastic Syndromes
Differential profile of PIP4K2A expression in hematological malignancies.
Neoplasm Metastasis
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma.
Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.
Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer.
Neoplasms
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer.
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma.
Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.
Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.
Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KII? as anti-tumor strategy.
High-throughput proteomics of breast cancer interstitial fluid: identification of tumor subtype-specific serologically relevant biomarkers.
Identification and characterization of human ARHGAP23 gene in silico.
Long non-coding RNA PXN-AS1 suppresses pancreatic cancer progression by acting as a competing endogenous RNA of miR-3064 to upregulate PIP4K2B expression.
Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.
Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks.
Novel phosphatidylinositol 4-kinases III beta (PI4KIII?) inhibitors discovered by virtual screening using free energy models.
Pharmacological inhibition of PI5P4K?/? disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer.
PIP4K and the role of nuclear phosphoinositides in tumour suppression.
PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia.
PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma.
PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis.
PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.
PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity.
PtdIns5P is an oxidative stress-induced second messenger that regulates PKB activation.
Regulatory Network and Prognostic Effect Investigation of PIP4K2A in Leukemia and Solid Cancers.
Silencing of type II phosphatidylinositol 4-kinase ? stabilizes prostate apoptosis response-4 and induces apoptosis in cancer cells.
Targeting Phosphatidylinositol 4-Kinase III? for Radiosensitization: A Potential Model of Drug Repositioning Using an Anti-Hepatitis C Viral Agent.
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.
The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?
The response to neoadjuvant chemoradiotherapy with 5-fluorouracil in locally advanced rectal cancer patients: a predictive proteomic signature.
Type II Kinase Inhibitors: An Opportunity in Cancer for Rational Design.
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
Neuralgia
Netrin-1 contributes to peripheral nerve injury induced neuropathic pain via regulating phosphatidylinositol 4-kinase IIa in the spinal cord dorsal horn in mice.
Neuroblastoma
Attenuation of focal adhesion kinase signaling following depletion of agonist-sensitive pools of phosphatidylinositol 4,5-bisphosphate.
Neuroinflammatory Diseases
Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage.
Obesity
Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta.
Pancreatic Neoplasms
Correction to: Long non-coding RNA PXN-AS1 suppresses pancreatic cancer progression by acting as a competing endogenous RNA of miR-3064 to upregulate PIP4K2B expression.
Long non-coding RNA PXN-AS1 suppresses pancreatic cancer progression by acting as a competing endogenous RNA of miR-3064 to upregulate PIP4K2B expression.
Paraplegia
Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation.
Peripheral Nerve Injuries
Netrin-1 contributes to peripheral nerve injury induced neuropathic pain via regulating phosphatidylinositol 4-kinase IIa in the spinal cord dorsal horn in mice.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A MIGICCL Study.
Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility.
BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia.
Differential profile of PIP4K2A expression in hematological malignancies.
Regulatory Network and Prognostic Effect Investigation of PIP4K2A in Leukemia and Solid Cancers.
Rectal Neoplasms
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma.
Sarcoma, Avian
Differential expression of type I and type II cyclic AMP-dependent protein kinases during cell cycle and cyclic AMP-induced growth arrest.
Severe Acute Respiratory Syndrome
Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase III? (PI4KB).
Phosphatidylinositol 4-Kinase III? Is Required for Severe Acute Respiratory Syndrome Coronavirus Spike-mediated Cell Entry.
Spastic Paraplegia, Hereditary
Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation.
Screening for mutations in the phosphatidylinositol 4-kinase 2-alpha gene in autosomal recessive hereditary spastic paraplegia.
Stomach Neoplasms
Electrostatic explanation of D1228V/H/N-induced c-Met resistance and sensitivity to type I and type II kinase inhibitors in targeted gastric cancer therapy.
Tuberculosis
Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.
Virus Diseases
Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks.
Novel phosphatidylinositol 4-kinases III beta (PI4KIII?) inhibitors discovered by virtual screening using free energy models.
The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase III?, PI4KB, through ACBD3.