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Information on EC 2.7.1.149 - 1-phosphatidylinositol-5-phosphate 4-kinase and Organism(s) Mus musculus and UniProt Accession Q91XU3

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Mus musculus
UNIPROT: Q91XU3 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphatidylinositol 4-kinase, type ii kinase, pip4k2a, type ii ptdins 4-kinase, pip4k, pip4k2b, pip4k2c, mss4p, type ii phosphatidylinositol 4-kinase, phosphatidylinositol 5-phosphate 4-kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-phosphatidylinositol-5-phosphate 4-kinase
-
phosphatidylinositol phosphate kinase II gamma
-
PIP4Kgamma
isoform
PtdIns5P 4-kinase
-
1-phosphatidylinositol-4-phosphate 5-kinase
-
-
-
-
1-phosphatidylinositol-4-phosphate kinase
-
-
-
-
Diphosphoinositide kinase
-
-
-
-
phosphatidylinositol 5-phosphate 4-kinase
-
-
phosphatidylinositol 5-phosphate 4-kinase gamma
-
-
phosphatidylinositol 5-phosphate, 4-kinase alpha
-
isoform
phosphatidylinositol 5-phosphate, 4-kinase beta
-
isoform
phosphatidylinositol-5-phosphate 4-kinase
-
-
PI5P4Kalpha
PI5P4Kbeta
-
isoform
PI5P4Kgamma
PIP(4)K
-
-
-
-
Pip4k2a
-
-
Pip4k2b
-
-
PIP5KII-alpha
-
-
-
-
PIP5KIII
-
-
-
-
PIPKII
-
-
-
-
PIPKIIalpha
-
-
PtdIns(4)P-5-kinase B isoform
-
-
-
-
PtdIns(4)P-5-kinase C isoform
-
-
-
-
type II alpha phosphatidylinositol-5-phosphate 4-kinase
-
-
type II PIP kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
104645-76-3
-
247907-17-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
-
-
-
ir
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
-
-
-
ir
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NIH-12848
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.001
NIH-12848
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high mRNA expression
Manually annotated by BRENDA team
restricted expression in the thick ascending limb of the loop of Henle and in the intercalated cells of the collecting duct
Manually annotated by BRENDA team
cortex and outer medulla, regulation of vesicular transport in specialized kidney epithelial cells
Manually annotated by BRENDA team
high mRNA expression
Manually annotated by BRENDA team
-
isoform PI5P4Kalpha is expressed in adulthood, whereas isoform PI5P4Kbeta is expressed early in development
Manually annotated by BRENDA team
-
isoform PI5P4Kbeta is expressed in neuronal populations, especially hippocampus and cortex
Manually annotated by BRENDA team
-
isoform PI5P4Kalpha localizes to white matter tracts, especially the corpus callosum
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
isoform PI5P4Kbeta is expressed in neuronal populations, especially hippocampus and cortex
Manually annotated by BRENDA team
-
both isoforms PI5P4Kalpha and PI5P4Kbeta are contained in axon terminals and dendritic spines adjacent to the synaptic membrane
Manually annotated by BRENDA team
-
quantitative real-time PCR enzyme expression analysis
Manually annotated by BRENDA team
-
quantitative real-time PCR enzyme expression analysis
Manually annotated by BRENDA team
-
inner segment
Manually annotated by BRENDA team
additional information
-
light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the ROS membrane
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
partial Golgi localization, primarily the matrix of the cis-Golgi
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
two subfamilies of phosphatidylinositol 5-phosphate 4-kinase kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell
malfunction
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mice lacking both enzyme isoforms in the liver have a defect in the ability to catabolize lipid droplets following a period of fasting. Enzyme loss of both isoforms results in lipid droplets accumulation and autophagy defects in MEF cells. Enzyme loss modifies expression of lysosomal and mTORC1 genes and alters metabolism as well as increases transcription factor EB nuclear translocation and activity
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PI42C_MOUSE
421
0
47336
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
47000
predicted and confirmed by western blotting, represents the phosphorylated form of mature PIP4Kgamma
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
glutathione Sepharose column chromatography
-
glutathione Sepharose column chromatography, and gel filtration
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
-
quantitative real-time PCR expression analysis, expression of isozyme PIPKIIalpha in Xenopus laevis oocytes
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the expression of isoform PI5P4Kgamma increases when the cells grow to confluence and polarize
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Clarke, J.H.; Emson, P.C.; Irvine, R.F.
Localization of Phosphatidylinositol phosphate Kinase II gamma in kidney to a membrane trafficking compartment within specialized cells of the nephron
Am. J. Physiol. Renal Physiol.
295
F1422-1430
2008
Homo sapiens (Q8TBX8), Mus musculus (Q91XU3)
Manually annotated by BRENDA team
Huang, Z.; Anderson, R.E.; Cao, W.; Wiechmann, A.F.; Rajala, R.V.
Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase
Neurochem. Res.
36
627-635
2011
Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Clarke, J.H.; Giudici, M.L.; Burke, J.E.; Williams, R.L.; Maloney, D.J.; Marugan, J.; Irvine, R.F.
The function of phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4Kgamma) explored using a specific inhibitor that targets the PI5P-binding site
Biochem. J.
466
359-367
2015
Mus musculus
Manually annotated by BRENDA team
Noch, E.K.; Yim, I.; Milner, T.A.; Cantley, L.C.
Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain
J. Comp. Neurol.
529
434-449
2020
Mus musculus
Manually annotated by BRENDA team
Lundquist, M.; Goncalves, M.; Loughran, R.; Possik, E.; Vijayaraghavan, T.; Yang, A.; Pauli, C.; Ravi, A.; Verma, A.; Yang, Z.; Johnson, J.; Wong, J.; Ma, Y.; Hwang, K.; Weinkove, D.; Divecha, N.; Asara, J.; Elemento, O.; Rubin, M.; Kimmelman, A.; Pause, A.
Phosphatidylinositol-5-phosphate 4-kinases regulate cellular lipid metabolism by facilitating autophagy
Mol. Cell.
70
531-544
2018
Mus musculus
Manually annotated by BRENDA team