Reference on EC 2.7.1.148 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rohdich, F.; Wungsintaweekul, J.; Luttgen, H.; Fischer, M.; Eisenreich, W.; Schuhr, C.A.; Fellermeier, M.; Schramek, N.; Zenk, M.H.; Bacher, A.
Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato
Proc. Natl. Acad. Sci. USA
97
8251-8256
2000
Solanum lycopersicum (P93841), Solanum lycopersicum
Kuzuyama, T.; Takagi, M.; Kaneda, K.; Watanabe, H.; Dairi, T.; Seto, H.
Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
Tetrahedron Lett.
41
2925-2928
2000
Escherichia coli
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Bernal, C.; Mendez, E.; Terencio, J.; Boronat, A.; Imperial, S.
A spectrophotometric assay for the determination of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity
Anal. Biochem.
340
245-251
2005
Escherichia coli
Wada, T.; Kuzuyama, T.; Satoh, S.; Kuramitsu, S.; Yokoyama, S.; Unzai, S.; Tame, J.R.; Park, S.Y.
Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis
J. Biol. Chem.
278
30022-30027
2003
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Miallau, L.; Alphey, M.S.; Kemp, L.E.; Leonard, G.A.; McSweeney, S.M.; Hecht, S.; Bacher, A.; Eisenreich, W.; Rohdich, F.; Hunter, W.N.
Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
Proc. Natl. Acad. Sci. USA
100
9173-9178
2003
Escherichia coli
Lherbet, C.; Pojer, F.; Richard, S.B.; Noel, J.P.; Poulter, C.D.
Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway
Biochemistry
45
3548-3553
2006
Agrobacterium tumefaciens
Hirsch, A.K.; Lauw, S.; Gersbach, P.; Schweizer, W.B.; Rohdich, F.; Eisenreich, W.; Bacher, A.; Diederich, F.
Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy
ChemMedChem
2
806-810
2007
Escherichia coli
Sgraja, T.; Alphey, M.S.; Ghilagaber, S.; Marquez, R.; Robertson, M.N.; Hemmings, J.L.; Lauw, S.; Rohdich, F.;Bacher, A.; Eisenreich, W.; Illarionova, V.; Hunter, W.N.
Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery
FEBS J.
275
2779-2794
2008
Aquifex aeolicus (O67060), Aquifex aeolicus
Kim, S.M.; Kim, Y.B.; Kuzuyama, T.; Kim, S.U.
Two copies of 4-(cytidine 5-diphospho)-2-C-methyl-D: -erythritol kinase (CMK) gene in Ginkgo biloba: molecular cloning and functional characterization
Planta
228
941-950
2008
Ginkgo biloba (A6XAA8), Ginkgo biloba (A6XAA9), Ginkgo biloba
Gimenez-Oya, V.; Villacanas, O.; Fernandez-Busquets, X.; Rubio-Martinez, J.; Imperial, S.
Mimicking direct protein-protein and solvent-mediated interactions in the CDP-methylerythritol kinase homodimer: a pharmacophore-directed virtual screening approach
J. Mol. Model.
15
997-1007
2009
Escherichia coli
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Kalinowska-Tluscik, J.; Miallau, L.; Gabrielsen, M.; Leonard, G.A.; McSweeney, S.M.; Hunter, W.N.
A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure
Acta Crystallogr. Sect. F
66
237-241
2010
Escherichia coli (P62615), Escherichia coli
Tang, M.; Odejinmi, S.I.; Allette, Y.M.; Vankayalapati, H.; Lai, K.
Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria
Bioorg. Med. Chem.
19
5886-5895
2011
Escherichia coli, Yersinia pestis, Escherichia coli DH5-alpha
Shan, S.; Chen, X.; Liu, T.; Zhao, H.; Rao, Z.; Lou, Z.
Crystal structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis
FASEB J.
25
1577-1584
2011
Mycobacterium tuberculosis (P9WKG7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKG7)
Tong, Y.; Su, P.; Zhao, Y.; Zhang, M.; Wang, X.; Hu, T.; Gao, W.; Huang, L.
Cloning and expression analysis of 4-(cytidine-5-diphospho)-2-C-methyl-D-erythritol kinase gene in Tripterygium wilfordii
Zhongguo Zhong Yao Za Zhi
40
4165-4170
2015
Tripterygium wilfordii
Liu, Z.; Jin, Y.; Tao, Y.; Wang, G.
Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly amongst IspD/IspE/IspF enzymes in the MEP pathway
Biosci. Rep.
38
BSR20171370
2018
Bacillus subtilis (P37550), Escherichia coli (P62615), Bacillus subtilis 168 (P37550), Bacillus subtilis DSM 23778 (P37550)
Kadian, K.; Vijay, S.; Gupta, Y.; Rawal, R.; Singh, J.; Anvikar, A.; Pande, V.; Sharma, A.
Structural modeling identifies Plasmodium vivax 4-diphosphocytidyl-2C-methyl-d-erythritol kinase (IspE) as a plausible new antimalarial drug target
Parasitol. Int.
67
375-385
2018
Plasmodium vivax (A5KAU8), Plasmodium vivax, Plasmodium vivax Salvador I (A5KAU8)
Jing, L.; Zheng, H.; Yao, N.; Chen, M.; Shen, Y.; Huang, L.
Cloning and expression analysis of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase gene in cc
Zhongguo Zhong yao za zhi
41
1578-1584
2016
Cinnamomum camphora (A0A1J0I9Y0)
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