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Information on EC 2.7.1.147 - ADP-specific glucose/glucosamine kinase and Organism(s) Mus musculus and UniProt Accession Q8VDL4
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2.7.1.147 ADP-specific glucose/glucosamine kinaseIUBMB Comments
Requires Mg2+. The enzyme, characterized from a number of hyperthermophilic archaeal species, is highly specific for ADP. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.
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Word Map
- 2.7.1.147
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hyperthermophilic
- thermococcus
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embden-meyerhof
- litoralis
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phosphofructokinases
- jannaschii
- furiosus
- glucokinases
- ribokinase
- methanococcales
- thermococcales
- 6-phosphofructokinase
- hexokinases
- atp-pfks
- methanosarcinales
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
Synonyms
adpgk, adp-dependent glucokinase, adp-pfk, adp-dependent kinase, tk1110, adp-gk, phpfk, adp-dependent hexokinase, adp-hk, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ADP-dependent glucokinase
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-
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ADP-specific glucokinase
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-
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ADP:D-glucose 6-phosphotransferase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho-group transfer
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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-, -
SYSTEMATIC NAME
IUBMB Comments
ADP:D-glucose/D-glucosamine 6-phosphotransferase
Requires Mg2+. The enzyme, characterized from a number of hyperthermophilic archaeal species, is highly specific for ADP. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.
CAS REGISTRY NUMBER
COMMENTARY
173585-07-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADP + D-fructose
AMP + D-fructose 6-phosphate
10% of the activity with D-glucose
-
-
?
ADP + D-mannose
AMP + D-mannose 6-phosphate
20% of the activity with D-glucose
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-
?
CDP + D-glucose
CMP + D-glucose 6-phosphate
12% of the activity with ADP
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-
?
GDP + D-glucose
GMP + D-glucose 6-phosphate
55% of the activity with ADP
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-
?
ADP + D-glucose
AMP + D-glucose 6-phosphate
best substrate concentration is 0.35 mM glucose, high concentrations are inhibitory
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-
?
additional information
?
-
no activity with ATP, GTP, CTP, UTP, TTP, diphosphate, polyphosphate, TDP, UDP, acetyl-phosphate, phosphoarginine, carbamoyl phosphate, phosphocreatine, and phosphoenolpyruvate as phosphoryl donors
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-
?
additional information
?
-
-
no activity with ATP, GTP, CTP, UTP, TTP, diphosphate, polyphosphate, TDP, UDP, acetyl-phosphate, phosphoarginine, carbamoyl phosphate, phosphocreatine, and phosphoenolpyruvate as phosphoryl donors
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Mg2+
excess Mg2+ is inhibitory, 55% inhibition at 55 mM, 41% at 15 mM, and 22% at 10 mM
additional information
no inhibition by D-glucose 6-phosphate, no or nearly no inhibition by L-glucose, glucose 1-phosphate, fructose 1-phosphate, 2,3-bisphosphoglycerate, succinate, proline, N-acetylglucosamine, diphosphate, mannose, galactose, fructose, ribose, NH4Cl, IMP, glucosamine, inositol, phosphocreatine, ATP, GTP, CTP, GDP, UTP, TTP, NADP+, oxaloacetate, TDP, CDP, UDP, palmitate, D-glucose 1,6-bisphosphate, and several other compounds, overview
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additional information
-
no inhibition by D-glucose 6-phosphate, no or nearly no inhibition by L-glucose, glucose 1-phosphate, fructose 1-phosphate, 2,3-bisphosphoglycerate, succinate, proline, N-acetylglucosamine, diphosphate, mannose, galactose, fructose, ribose, NH4Cl, IMP, glucosamine, inositol, phosphocreatine, ATP, GTP, CTP, GDP, UTP, TTP, NADP+, oxaloacetate, TDP, CDP, UDP, palmitate, D-glucose 1,6-bisphosphate, and several other compounds, overview
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
no activation by D-glucose 6-phosphate, no or nearly no inhibition by L-glucose, glucose 1-phosphate, fructose 1-phosphate, 2,3-bisphosphoglycerate, succinate, proline, N-acetylglucosamine, diphosphate, mannose, galactose, fructose, ribose, NH4Cl, IMP, glucosamine, inositol, and phosphocreatine
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additional information
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no activation by D-glucose 6-phosphate, no or nearly no inhibition by L-glucose, glucose 1-phosphate, fructose 1-phosphate, 2,3-bisphosphoglycerate, succinate, proline, N-acetylglucosamine, diphosphate, mannose, galactose, fructose, ribose, NH4Cl, IMP, glucosamine, inositol, and phosphocreatine
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ADPGK_MOUSE
496
0
53902
Swiss-Prot
Secretory Pathway (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme from Escherichia coli strain DH5alpha by nickel affinity and ion exchange chromatography, to homogeneity
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain DH5alpha
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
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