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Information on EC 2.7.1.137 - phosphatidylinositol 3-kinase and Organism(s) Dictyostelium discoideum and UniProt Accession P54675

for references in articles please use BRENDA:EC2.7.1.137
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EC Tree
IUBMB Comments
One mammalian isoform is known.
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This record set is specific for:
Dictyostelium discoideum
UNIPROT: P54675
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Word Map
The taxonomic range for the selected organisms is: Dictyostelium discoideum
The enzyme appears in selected viruses and cellular organisms
Synonyms
pi3k, phosphatidylinositol 3-kinase, pi3 kinase, vps34, phosphoinositide-3-kinase, phosphatidylinositol 3 kinase, ptdins 3-kinase, pik3c3, phosphatidylinositide 3-kinase, hvps34, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
kinase (phosphorylating), phosphatidylinositol 3-
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kinase, phosphatidylinositol 3- (phosphorylating)
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p85/p110 phosphoinositide 3-kinase
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phosphatidylinositol 3'-kinase
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phosphatidylinositol 3-kinase
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phosphoinositide 3'-kinase
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phosphoinositide 3-kinase
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PI 3-kinase
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PI3K
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PtdIns 3'-kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
One mammalian isoform is known.
CAS REGISTRY NUMBER
COMMENTARY hide
115926-52-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
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-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PI3K3_DICDI
1697
0
192942
Swiss-Prot
other Location (Reliability: 4)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Driscoll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.
Synthesis and function of 3-phosphorylated inositol lipids
Annu. Rev. Biochem.
70
535-602
2001
Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster
Manually annotated by BRENDA team
Zhou, K.; Takegawa, K.; Emr, S.D.; Firtel, R.A.
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development
Mol. Cell. Biol.
15
5645-5656
1995
Dictyostelium discoideum (P54673), Dictyostelium discoideum (P54674), Dictyostelium discoideum (P54675), Dictyostelium discoideum (P54676), Dictyostelium discoideum
Manually annotated by BRENDA team